WO2021093714A1 - 利用移动终端对目标成分进行检测的方法及系统 - Google Patents

利用移动终端对目标成分进行检测的方法及系统 Download PDF

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Publication number
WO2021093714A1
WO2021093714A1 PCT/CN2020/127664 CN2020127664W WO2021093714A1 WO 2021093714 A1 WO2021093714 A1 WO 2021093714A1 CN 2020127664 W CN2020127664 W CN 2020127664W WO 2021093714 A1 WO2021093714 A1 WO 2021093714A1
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Prior art keywords
test strip
test
area
image
mark
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PCT/CN2020/127664
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English (en)
French (fr)
Inventor
曹振
王静
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中国农业科学院农业质量标准与检测技术研究所
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Priority to JP2021524337A priority Critical patent/JP2023501012A/ja
Priority to AU2020383878A priority patent/AU2020383878A1/en
Priority to EP20886682.2A priority patent/EP4060337A4/en
Publication of WO2021093714A1 publication Critical patent/WO2021093714A1/zh
Priority to US17/744,556 priority patent/US11630107B2/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/8483—Investigating reagent band
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
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    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G06T5/80—
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/021—Identification, e.g. bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/069—Absorbents; Gels to retain a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
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    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7756—Sensor type
    • G01N2021/7759—Dipstick; Test strip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30204—Marker

Definitions

  • the present disclosure relates to the technical field of immunological detection, and in particular to a method and system for detecting target components using a mobile terminal, and a detection method for simultaneous screening of multiple targets.
  • test strip readers In the prior art, in order to eliminate the influence of personal subjective factors, most of the design test strip readers are used to read the test strips.
  • the test strip readers have a light source with a specific position and a specific intensity, as well as a camera at a specific position, and Generally, in a cassette, after taking an image, the color development area is relatively fixed, and the data reading is relatively accurate.
  • the test strip reader is inconvenient to carry, and the price is high, and it is not suitable for ordinary consumers to perform target detection at any time.
  • the purpose of the embodiments of the present disclosure is to provide a method for detecting target components using a mobile terminal, which can use the mobile terminal to detect multiple target components at the same time, and is not affected by factors such as the type of the mobile terminal and the tilt of the shooting angle.
  • the operator does not require high professionalism, and can perform qualitative and/or quantitative detection of targets anytime and anywhere under conventional ambient light conditions.
  • the embodiment of the present disclosure provides a method for detecting a target component using a mobile terminal, which includes:
  • test strip to detect the sample solution to be tested to obtain a color-developing test strip;
  • the test strip includes at least a personalized mark area and a result display area;
  • test strips Arranging test strips at equal angles around the same circle center to obtain a test strip arrangement ring; positioning marks are arranged on the test strip arrangement ring and outside the detection disk area of the test strips;
  • Identify the positioning mark in the collected image correct the collected image according to the positioning mark, and determine the personality of each test strip in the corrected image according to the preset positional relationship between the positioning mark and the test strip
  • the positions of the personalized mark area and the result display area are segmented according to the positions of the personalized mark area and the result display area of each test strip determined to separate the individual mark area and the result display area of each test strip.
  • the test result of the target component is output and displayed on the mobile terminal.
  • a personalized mark area is set on each test strip, and the personalized mark area is provided with identity information for identifying the type of test strip where it is located.
  • the test strips are arranged at equal angles around the same circle center. Compared with the non-circular array of test strips, the combination of test strips will cause the images of different test strips to have obvious differences due to the near large and far small when shooting.
  • the circumferential arrangement in the present disclosure It can make the image distortion of the collected test strips tend to be the same.
  • the image of the collected test strip is corrected by the positioning mark, which eliminates the image distortion caused by jitter, angle tilt and other reasons during the image collection process.
  • the precise position of the personalized mark area and the result display area in each test strip image is obtained according to the preset positional relationship, so that the image processing of the test strip result display area In the process, it is ensured that the segmented result display area matches the actual result display area to a higher degree, and then more accurate detection results can be obtained after comparing with the matched standard value. From this, it can be seen that the method in the present disclosure does not require high professionalism of the operator, and can perform qualitative and/or quantitative detection of the target under conventional ambient light conditions anytime and anywhere, and at the same time, the detection result has high accuracy.
  • the correcting the collected image according to the positioning identifier includes:
  • the position, size and direction of the test strips, positioning marks and other objects in the collected image can be made the same as the actual item, or there are devices.
  • a certain ratio relationship that is, the image can be enlarged or reduced in the same or equal proportion to the actual object.
  • the distortion of the image of the corrected test strip is basically the same, which is used for the result of image segmentation.
  • the area of the display area is basically the same, which improves the accuracy of the recognition of the color result in the result display area and provides a guarantee for the reliability of the detection result.
  • the correcting the captured image according to the positioning mark includes: identifying the position and/or shape of the positioning mark, and correcting the shooting angle of the captured image according to the position and/or shape of the positioning mark And/or correct the position deviation of the captured image.
  • the location mark has features (such as shape, boundary, position, size, color, etc.) that can be clearly distinguished from the surroundings.
  • features such as shape, boundary, position, size, color, etc.
  • the positioning mark has a predetermined shape and is arranged at a predetermined position
  • the positioning mark has a predetermined shape and a predetermined position.
  • the data processing center can match the shape and position of the positioning mark of the collected image according to the predetermined shape and the predetermined position to realize the correction of the collected image.
  • the shape of the positioning mark is a shape with obvious vertices and straight sides.
  • the test strip arrangement ring is obtained by restricting the test strips on the detection disk;
  • the positioning identifier is a marking block provided on the detection disk, and/or The positioning mark is the edge of the detection disc;
  • the positioning marks are marks that can position the test strips during the data collection process. These positioning marks can be clear marking blocks, or some structural features of the detection tray holding the test strips (such as Detect the edge of the disc, etc.).
  • the marking block is a distinguishing marking block and a comparison marking block provided on the detection disc.
  • the distinguishing mark block and the contrast mark block are used to mark the order and position of the test strips.
  • the segmentation of the images of the personalized mark area and the result display area in each test strip includes:
  • Identify the marker blocks in the captured image correct the captured image based on the marker blocks, and determine the personality of each test strip in the corrected image based on the preset positional relationship between the marker block and the test strip According to the position of the personalized mark area and the result display area of each test strip, the image segmentation is performed according to the determined position of the personalized mark area and the result display area of each test strip, and the segmentation of the personalized mark area and the result display area in each test strip is obtained.
  • the segmentation of the images of the personalized mark area and the result display area in each test strip includes:
  • Identify the edge of the detection disc in the collected image correct the collected image according to the edge of the detection disc, and determine each test paper in the corrected image according to the preset positional relationship between the edge of the detection disc and the test strip
  • the position of the personalized mark area and the result display area of each test strip is segmented according to the determined position of the personalized mark area and result display area of each test strip, and the personalized mark area and result display in each test strip are obtained.
  • the segmentation of the images of the personalized mark area and the result display area in each test strip includes:
  • the realization of identifying the positioning marks in the collected images, correcting the collected images according to the positioning marks, and segmenting the images of the personalized mark area and the result display area in each test strip can be understood as:
  • the correction of the collected image can be realized only by the marking block, or only by detecting the edge of the disc, and even more by the marking block and detecting the edge of the disc.
  • the correction result of the marking block and the detection result of the detection disc edge can be collated with each other, thereby improving the accuracy of image correction, improving the recognition accuracy and accuracy of the color development area, and improving the color rendering Reading accuracy of the color development results of the area.
  • the result display area in the test strip includes a T line and a C line;
  • the color rendering result is the ratio of the chromaticity value of the T-line image to the chromaticity value of the C-line image; or the color rendering result is the chromaticity value of the T-line image, and the chromaticity value includes RGB value, grayscale value or Luminosity value.
  • the color rendering result is calculated as the ratio of the chromaticity value of the T-line image to the chromaticity value of the C-line image, it includes:
  • the selected area of the background color is located near the T line or the C line in the result display area;
  • the selected area of the background color is located between the T line and the C line.
  • the method when the test strip is used to detect the target component, the method includes:
  • test strips are respectively placed in multiple sample containing chambers containing the target components, and the amount of sample liquid in the multiple sample containing chambers is the same; the tilt angles of the test strips into the sample containing chambers are the same, The time is the same.
  • test strips are subjected to chromatographic detection in the same volume of sample liquid at the same angle, and the chromatographic behavior is consistent, which can reduce the difference in color rendering results caused by operating errors and improve the color rendering results. reliability.
  • the method for detecting a target component using a mobile terminal further includes: calibrating the order of the test strips in the test strip arrangement ring through the marking block;
  • the pixels of the image acquisition device of the mobile terminal are at least 8 million.
  • the embodiment of the present disclosure also provides a method for synchronously detecting multiple targets, including:
  • the liquid sample to be tested is contained in a plurality of sample containing chambers;
  • test strip to perform chromatographic detection on the sample in the sample containing cavity;
  • the test strip includes at least a personalized mark area and a result display area;
  • test strips after the tomographic detection on a detection disk provided with a positioning mark the detection disk being able to arrange the test strips at an equal angle around the center of the detection disk in the same circular area;
  • the embodiment of the present disclosure also provides a method for synchronously detecting multiple targets, including:
  • the liquid sample to be tested is contained in a plurality of sample containing cavities with drip pipes at the bottom;
  • test strips Place the test strips on the test tray provided with positioning marks, the test strips are arranged at an equal angle around the center of the test tray in a circular area of the test tray; the test strips include at least personalized signs Area, result display area, liquid suction area;
  • test strip chromatography After the test strip chromatography is completed, use the mobile terminal to collect images of the test disk and the test strip on it;
  • the positioning mark provided on the upper surface of the detection disc is a marking block, which is used to position and mark the test strip during the image acquisition and processing process.
  • the marker block can also play a role in correcting the image.
  • the edge of the detection disc and the detection block are used for detection, which can improve the accuracy of image correction.
  • the mark block includes a difference mark block and a comparison mark block; the difference mark block is used to distinguish from the comparison mark block.
  • the total number of the distinguishing mark block and the comparison mark block is not less than three.
  • the distinguishing mark block and the comparison mark block can realize the marking of the sequence of the test strips. More than three marker blocks can better correct the shooting angle.
  • the shape of the marking block includes at least a vertex and a straight edge.
  • Marking blocks with vertices and straight edges are easier to identify and locate, so as to achieve accurate image correction.
  • the marking block is a blue square color block and three green square color blocks, or the marking block is a green square color block and three blue square color blocks.
  • Blue, green, and yellow are stable colors. When recognizing the edge of the mark, it is not easily affected by ambient light, and the recognition result is more accurate.
  • the upper surface of the detection disk is a regular polygon.
  • Regular polygons have clear vertices and edges, which are easier to recognize during image processing, and match the shape preset by the data processing center, that is, the image correction is more accurate.
  • the upper surface of the detection disc is a neutral color surface.
  • the upper surface of the detection disk is a diffuse reflection surface.
  • the neutral color surface is less affected by external light sources, and its reflected light has little interference with the color of the color rendering area.
  • the color rendering result can be read more accurately. There will be no light spots reflected by the light source on the diffuse reflection surface, which will cause interference with image acquisition.
  • the amount of sample liquid in the multiple sample containing chambers is the same; the test strip and the sample containing cavity The contact time of the liquid sample is the same.
  • the same test conditions can reduce the color rendering result error caused by the operation error.
  • the inclination angle of the test strip inserted into the sample accommodating cavity is the same.
  • the insertion angle of the test strip is also a variable factor of the operation, and the same insertion angle of the test strip can also reduce the operation
  • the result of the error shows the error.
  • the dripping pipe is placed at the same position above the liquid suction area of the test strip.
  • the contact position of the sample liquid on the test strip is also a variable factor of the operation.
  • the same sample liquid contact position can also reduce the result display error caused by the operation error.
  • the upper surface of the test strip is flush with the upper surface of the test tray.
  • the upper surface of the result display area is flush with the upper surface of the detection disk.
  • the upper surface of the test strip (especially the upper surface of the test strip result display area) is flush with the upper surface of the detection disk, which can reduce the shadow caused by the light source and improve the color of the color area during data processing. Degree of recognition accuracy, improve the accuracy of detection results.
  • the pixels of the image acquisition device of the mobile terminal are at least 8 million.
  • a test strip holding groove recessed downward from the upper surface of the test tray is provided on the test tray for holding the test strip.
  • the test strip holding slot can play the role of limiting the position of the test strip, avoiding the sliding of the test strip due to problems such as the placement angle.
  • an isolation block for separating the lower surface of the test strip from the bottom of the test strip holding groove is provided at the bottom of the test strip holding groove.
  • the isolation block can separate the test strip from the bottom of the test strip holding tank, prevent the sample liquid on the test strip from contaminating the test strip holding tank, reduce sample contamination during continuous sample testing, and improve the accuracy of results.
  • the personalized mark area is made close to the center of the test disk, and the test strip holding slot is accommodated
  • the border of the area of the test strip matches the shape of the test strip.
  • the frame of the area containing the test strip in the test strip holding groove matches the shape of the test strip, which can reduce the gap between the test strip and the test strip holding groove, and avoid being recognized as a personalized sign by the data processing center Part of the personalized mark of the area affects the selection of the standard database; at the same time, it can also avoid the interference of the gap shadow on the T line and C line recognition of the color rendering area.
  • the embodiment of the present disclosure also provides a system for detecting target components using a mobile terminal, including:
  • the sample liquid detection device includes a test strip and a detection disk; the test strip includes at least a personalized mark area and a result display area; the detection disk is used to limit the test strips to be arranged at equal angles around the same circle center to obtain the test strip Strip arrangement ring; the detection disc is also provided with a positioning mark for locating the position of the test strip in the test strip arrangement ring after image acquisition;
  • An image acquisition device which is provided on the mobile terminal and is configured to perform image acquisition on the test strip arrangement ring;
  • the data processing device is configured to perform data processing on the collected image, identify the positioning mark in the collected image, and correct the collected image according to the positioning mark, according to the difference between the positioning mark and the test strip
  • the preset position relationship determines the position of the personalized mark area and the result display area of each test strip in the corrected image, and performs image segmentation according to the determined position of the personalized mark area and result display area of each test strip. Obtain the segmented images of the personalized mark area and the result display area in each test strip, and obtain the test result of the target component;
  • the test result receiving device is configured to receive the test result of the target component, and the test result receiving device is arranged on the mobile terminal.
  • the described system for detecting target components using a mobile terminal has a simple device, a sample liquid detection device is small in size, and easy to carry.
  • the image acquisition device, data processing device, and test result receiving device can be mounted on the mobile terminal or the cloud to reduce The difficulty of the operation is improved, and the promotion of the detection method of the target component is more convenient.
  • the system for detecting target components using a mobile terminal can realize multi-channel detection, and the detection result is reliable.
  • the system is used to perform the method of using a mobile terminal to detect target components provided in the embodiments of the present disclosure; or the system is used to perform the synchronization of multiple targets provided in the embodiments of the present disclosure.
  • the method of testing is used to perform the method of using a mobile terminal to detect target components provided in the embodiments of the present disclosure; or the system is used to perform the synchronization of multiple targets provided in the embodiments of the present disclosure. The method of testing.
  • the system for detecting a target component using a mobile terminal can perform detection in different ways, and is preferably used to perform the method for detecting a target component using a mobile terminal provided by the embodiment of the present disclosure; or perform the comparison provided by the embodiment of the present disclosure.
  • the data processing device includes:
  • the image correction unit is configured to identify the positioning mark in the collected image and correct the collected image according to the positioning mark;
  • the image segmentation unit is configured to segment the images of the personalized mark area and the result display area in each test strip;
  • the calculation unit is configured to calculate the color rendering result of the result display area, and compare the color rendering result with the standard color rendering result in a pre-established standard database that matches the identity information in the personalized logo area, Obtain the test result of the target ingredient.
  • the various components of the data processing device can realize the correction of the collected images, and solve the problem of the vastly different collected images of the mobile terminal and the inaccurate recognition results; combined with the segmentation unit, the required area (individualized logo area and result display area) can be realized.
  • the accurate segmentation optionally, in combination with the calculation unit, the color rendering result of the accurately segmented color rendering area can be read.
  • the data processing device is an implementation of the system data processing device that uses a mobile terminal to detect target components provided by the present disclosure.
  • Those skilled in the art can choose any data that can be used to perform data on the image captured by the mobile terminal. Processing, any implementation of a data processing center that obtains reliable test results.
  • the data processing device is provided on the mobile terminal; or the data processing device is provided on a remote terminal communicatively connected with the mobile terminal.
  • the present disclosure has the following beneficial effects:
  • the present disclosure provides a method for detecting target components using a mobile terminal, using a circular array of test strips to arrange the test strips, and segmenting the required test strips area by identifying the positioning marks in the image recognition process. Obtain the chromaticity value and compare it with the chromaticity value of the corresponding standard database to obtain the test result.
  • This method omits the process of directly identifying the color area, and reduces the disadvantage of large recognition errors in the width direction of the test strip due to inaccurate edge recognition.
  • this processing process can achieve multi-channel detection, and The test strips of each channel can output reliable test results.
  • the present disclosure provides a method for simultaneous detection of multiple targets. It only needs to perform tomographic detection of test strips, display the test strips, take pictures of the mobile terminal, and upload the system.
  • the test results can be obtained and the process It is simple, easy to operate, easy to promote, and achieves accurate measurement for the detection of target components of the sample liquid; at the same time, it can use the mobile terminal to realize the detection of multi-channel test strips.
  • the present disclosure also provides a system for detecting target components using a mobile terminal, using only a sample liquid detection device, a mobile terminal equipped with an image acquisition device and a test result receiving device, and a data processing device (which can be in the cloud or The mobile terminal) can achieve the detection of the target component, the device is easy to carry, can be used at home, is easy to market, and the test result is reliable.
  • FIG. 1 is a flow chart of using a mobile terminal to detect a target component according to an embodiment of the disclosure
  • FIG. 2 is a schematic diagram showing the structure of a test disk and test strips arranged on the test disk according to an embodiment
  • FIG. 3 is a flowchart of synchronous detection of multiple targets according to an embodiment of the present disclosure
  • FIG. 4 is a flowchart of synchronous detection of multiple targets according to an embodiment of the disclosure.
  • Fig. 5 is a structural schematic diagram showing the assembling of multiple sample containing cavities according to an embodiment
  • Fig. 6 is a bottom view of an assembling structure of a plurality of sample containing chambers according to an embodiment
  • Fig. 7 is a schematic structural diagram of a system for detecting target components using a mobile terminal according to an embodiment.
  • test strip 100 detection plate 200, distinguishing mark block 300, comparison mark block 400, sample containing cavity 500, hollow cavity 510, bayonet 520, drip line 530, cartridge column 540, sample liquid detection Device 710, image acquisition device 720, data processing device 730, image correction unit 731, image segmentation unit 732, calculation unit 733, test result receiving device 740
  • the present disclosure is implemented by immunological detection technology, so the methods and systems described in the embodiments of the present disclosure all use test strips for immunological detection.
  • the test strip in the embodiment of the present disclosure at least includes a sample pad for dripping sample liquid, the sample pad is misplaced and superimposed on the colloidal gold pad, the MAX line is set at the intersecting place of the colloidal gold pad and the sample pad, and the colloidal gold
  • the other end of the pad is overlapped with a nitrocellulose membrane, and the other end of the nitrocellulose membrane is overlapped with a water-absorbing material.
  • the nitrocellulose membrane is provided with a T line (detection line) and a C line (quality control line). It is used to develop the color reaction of the target in the sample solution. In the test strip, the T line and the C line will show different colors according to the content of the target in the sample solution.
  • the content of the target in the sample solution can be obtained.
  • the sample pad and the colloidal gold pad part can be covered with a personalized mark to obtain a personalized mark area
  • the absorbent material part can also be covered with a personalized mark to obtain a personalized mark area: the area of the nitrocellulose membrane is the result display Color zone.
  • the test strip in the embodiment of the present disclosure at least includes a personalized mark area, a result display area, and a capillary area.
  • the capillary area is used to adsorb the liquid sample into the test strip and allow the liquid sample to enter the area where the colloidal gold layer is provided for the color reaction, and the color test result is displayed in the result display area.
  • the T line detection line
  • C line quality control line
  • the color reaction can only obtain the detection result through the color reaction of the T line, or both the T line and the C line.
  • the result of color development is combined to obtain the test result.
  • the personalized logo area is used to set identity information, which includes, but is not limited to, the type, brand, and batch number of the test strip.
  • the identification information is identifiable information, such as a two-dimensional code, a barcode, and so on.
  • the personalized mark area can be set in any area except the result display area, and it does not need to block the result display area.
  • a standard database Before the detection of the target component, a standard database must be established for each type of test strip in advance. In the standard database, a mapping relationship between the color reaction result and the content of the target component should be established.
  • the typical but non-restrictive mapping relationship between the color reaction result and the content of the target component is the external standard method, that is, the sample solution of the existing known concentration of the target component is selected for the test strip of the existing specific personalized logo. Chromatographic detection, and then use the method provided in the present disclosure to perform the corresponding relationship between the color development results of the chromatographic test paper and the concentration.
  • the sample solution of the target component with the known concentration is S101 ⁇ S106, S301 ⁇ S306 or Any one of S401 to S406 is performed to perform detection, and a color development result that matches the concentration of the target component is obtained.
  • FIG. 1 is a flowchart of detecting target components using a mobile terminal according to an embodiment of the disclosure.
  • the method of using a mobile terminal to detect a target component includes the following steps:
  • S101 Use a test strip to detect the target component to obtain a colored test strip.
  • using test strips to detect target components may include using different types of test strips to detect corresponding target objects, for example, using urine test strips to detect urine samples, and using blood test strips to detect blood samples. It can also be the same sample liquid, but screen multiple components in the sample liquid, such as screening multiple pesticide residues, mycotoxins, and environmental pollutants in the same tea sample liquid.
  • using test strips to detect target components may include using the same type of test strips to detect the same target in different samples. Such as the detection of tebuconazole (a kind of pesticide residue) in different teas.
  • test strips in the present disclosure may include, but are not limited to, pesticide residue component test strips, various test strips used in the medical field, test strips for environmental pollution component testing, and the like.
  • S102 Arrange the test strips at equal angles around the same circle center to obtain a test strip array ring; a positioning mark is provided on the test strip array ring and outside the test strips.
  • the test strip arrangement ring can be obtained by restricting the test strip on the detection plate.
  • Fig. 2 is a schematic diagram showing the structure of a test disc and test strips arranged on the test disc according to an embodiment. Referring to FIG. 2, the test strips 100 are arranged at equal angles around the center of the detection disk 200. As shown in the figure, the test tray 200 is a hexagonal test tray. Six test strips 100 are placed in the hexagonal test tray.
  • each test strip 100 is close to a corner of the test tray 200, and each test strip The strips extend toward the center of the test disk 200, so that the other end of each test strip is close to the center of the test disk; the length of the test strip 100 and the size of the test disk 200 are set such that the center of each test strip is close to the center of the test disk.
  • the ends of the test strips are spaced apart from the center of the detection disk and the ends of each test strip close to the center of the detection disk are spaced apart from each other.
  • the arrangement of the above-mentioned hexagonal detection disc and test strips is only exemplary, and the present disclosure does not specifically limit the shape of the detection disc and the arrangement of the test strips, and other shapes of detection discs and test strips can be used. Arrangement of other test strips.
  • An implementation of limiting the test strip on the test tray may be that a test strip holding slot for accommodating the test strip is provided on the test tray, and the test strip is limited to the test strip.
  • the upper surface of the test strip can optionally be flush with the upper surface of the test plate.
  • test strip holding slot to limit the test strip
  • test strip can also be limited by other limiting structures, such as a cylindrical or multi-prismatic limit block , Limit baffle, limit slot and other structures, or a combination of at least two, to limit the test strip.
  • the present disclosure does not specifically limit the limit structure. Anything that can be implemented on the test disc
  • the structure in which the test strips are arranged at equal angles into the test strip array ring falls within the protection scope of the present disclosure.
  • the positioning mark may be a marking block set on the detection disc 200.
  • the marking block may be a distinguishing mark block 300 and a comparison mark block 400 set on the detection disc 200.
  • the distinguishing mark block 300 is used for distinguishing from the comparison mark block 400.
  • the shape of the marking block may include at least a vertex and a straight edge.
  • the shape of the identification block is a square block.
  • the upper surface of the marking block is square.
  • the shape of the upper surface of the marking block can also be other regular polygons or regular figures with vertices and straight edges.
  • the present disclosure does not specifically limit the shape of the upper surface of the marking block, but it is based on rules including vertices and straight edges.
  • the graphics are preferred, such as polygons or regular polygons, pentagrams and so on.
  • the upper surface area of the distinguishing mark block 300 and the comparison mark block 400 may be equal, and the distinguishing mark block 300 and the contrast mark block 400 may be arrayed around the center circumference of the detection disc 200 and close to the detection zone. The outer edge of the disc is set.
  • arranging the distinguishing mark block 300 and the comparison mark block 400 on the outer edge of the detection disc can make the mark block as far away from the center of the detection disc as possible, and each collected The image definition of each marking block is higher.
  • the angle and position of the picture can be corrected more accurately through the marking block.
  • the geometric center line of the distinguishing marking block 300 and the contrast marking block 400 may enclose a square area, and the center of the square area coincides with the center of the detection disc. This design scheme can simplify the correction algorithm and increase the information capacity and processing speed of the data processing center.
  • the upper surface of the distinguishing marking block 300 is a blue square, and the upper surface of the contrast marking block 400 is three green squares; or the upper surface of the distinguishing marking block 300 is a green Square, the upper surface of the contrast marker block 400 is three blue squares.
  • blue and green are colors with relatively stable chromaticity, which are less affected by the brightness of the ambient light, and have higher accuracy in boundary recognition, which is beneficial to the accurate correction of the collected image.
  • the solutions to the shape, color, and arrangement position of the identification block shown in the above embodiments are only exemplary.
  • the present disclosure does not specifically limit the shape, color, and arrangement position of the identification block.
  • the positioning mark may be the edge of the detection disk 200, in the detection disk 200 shown in FIG. 2, that is, the six sides of the hexagonal detection disk.
  • the positioning mark may be a combination of both the marking block and the edge of the detection disc 200.
  • the present disclosure does not specifically limit the edge shape of the detection disk 200, but as a preferred embodiment, the edge of the detection disk 200 is also a regular pattern including vertices and straight edges.
  • S103 Use the mobile terminal to collect images of the test strip arrangement ring, and upload the collected images to the data processing center.
  • the mobile terminals in the embodiments of the present disclosure may include, but are not limited to, mobile phones, notebooks, tablet computers, POS machines, and even vehicle-mounted computers. Any terminal equipped with an image acquisition device can fall into the protection scope of the present disclosure.
  • the image capture device of the mobile terminal has at least 8 million pixels (for example, 9 million, 10 million, 12 million, 15 million, 16 million, 18 million, 20 million, 23 million, 28 million, 35 million, 40 million, etc.).
  • S104 Identify the positioning mark in the collected image, and correct the collected image according to the positioning mark, and segment the image of the personalized mark area and the result display area in each test strip.
  • the preset positional relationship between the positioning indicator and the test strip may be a preset positional relationship, or may be limited to a predetermined positional relationship between the test strip and the corresponding device.
  • the relationship between the position of the test strip in the test tray and the positioning mark on the test tray is a fixed relationship.
  • the positioning mark and the test strip are fixed. The relationship between is the established positional relationship between the test strip in the test tray and the positioning mark, because in the test strip, the position of the result display area and the personalized mark area in the test strip is also the established positional relationship.
  • the method for correcting the collected image is: determining the individualization of each test strip in the corrected image according to the preset positional relationship between the marking block and the test strip The location of the marker area and the result display area.
  • the method of correcting the collected image is: determining the personalized mark area of each test strip in the corrected image according to the preset position relationship between the edge of the detection disc and the test strip And the location of the result display area.
  • the method for correcting the collected image is: determining the position of the detection disc edge according to the preset positional relationship between the marking block and the edge of the detection disc ; And according to the preset positional relationship between the edge of the detection disc and the test strips, the position of the personalized mark area and the result display area of each test strip in the corrected image is determined.
  • image segmentation is performed to obtain the segmented images of the personalized mark area and the result display area of each test strip.
  • the determination of the positions of the personalized sign area and the result display area through the above-mentioned preset positional relationship is only exemplary, and the present disclosure does not determine the position of the personalized sign area and the result display area by which positional relationship. Specific restrictions.
  • S105 Calculate the color rendering result of the result display area, and compare the color rendering result with the standard color rendering result in the pre-established standard database matching the identity information in the personalized mark area to obtain the test result of the target component.
  • the display result usually uses a T/C contrast curve to display the mapping relationship between the color rendering result and the target component content. If the test strip is a line elimination test strip, the T-line image chromaticity value is usually used to show the mapping relationship between the color rendering result and the target component content.
  • the chromaticity value of the T-line image and the chromaticity value of the C-line image need to be calculated.
  • the chromaticity value can be Including but not limited to RGB value, gray value or photometric value.
  • the color rendering result when the color rendering result is the ratio of the chromaticity value of the T-line image to the chromaticity value of the C-line image, it may include:
  • the ratio of the chromaticity value of the T-line image relative to the background color and the chromaticity value of the C-line image relative to the background color is used as the color development result.
  • the selected area of the background color may be located near the T line or the C line in the result display area. Since the color rendering result is mainly the chromaticity ratio of the T line and the C line, if the background color is selected too far from the T line and the C line, the background noise selection will be inaccurate, which will affect the accuracy of the color rendering result.
  • the background color selection is near the T line and the C line in the result color area.
  • the material in the result color area is basically the same, and the reflection behavior of light is the same. On the other hand, the distance is closer, and the background de-dyeing effect is better.
  • the selected area of the background color may be located between the T line and the C line.
  • T line and C line share a background color for de-drying, and the color comparison result is more reliable.
  • the image of the predetermined area between the T-line and the C-line is used as the background color.
  • the advantage is that the ratio of the chromaticity value of the T-line image and the chromaticity value of the C-line image will be more accurate.
  • the test paper During the detection process the strip may have other interference colors, or be affected by the ambient light during the image shooting process.
  • the tomography or the background color of the result display area under the same shooting conditions are the same Taking the chromaticity value of the image in the predetermined area between the T-line and the C-line of the test strip in the collected image as the background color, which is equivalent to filtering the interference of the interference color on the chromaticity value of the T-line image and the C-line image. It can be seen that the calculation method is not affected by other interference colors, so that the calculation of the color rendering result is more accurate.
  • S106 Output the test result of the target component and display it on the mobile terminal.
  • the precise position of the personalized mark area and the result display area in each test strip image is obtained according to the preset position relationship, so that the test strip
  • the segmented result display area can be more closely matched with the actual result display area, thereby improving the accuracy of reading the color rendering result, and further improving the accuracy of the detection result.
  • the present disclosure achieves the purpose of simultaneously detecting multiple target components by using a mobile terminal, has low operation difficulty, is convenient to carry, and can realize detection at any time, and the detection result is reliable.
  • multi-channel detection can be performed, and the multi-channel detection results are relatively reliable.
  • test result of the target component can be output on the mobile terminal used for image collection, on any mobile terminal that can transmit data with the data processing center, or on the data storage of the data processing center Department to store data for retrieval at any time.
  • FIG. 3 is a flowchart of synchronous detection of multiple targets according to an embodiment of the disclosure. Referring to Fig. 3, the method of synchronously detecting multiple targets includes the following steps:
  • the liquid sample to be tested is contained in a plurality of sample containing cavities.
  • FIG. 5 is a schematic view showing the structure of assembling a plurality of sample containing cavities according to an embodiment.
  • a plurality of sample containing cavities 500 are integrally formed to form a cylinder with a hollow cavity 510 in the middle.
  • Each sample containing cavity 500 includes an outer wall for enclosing the outer periphery of the cylinder, and one for enclosing Into the inner wall of the middle cavity.
  • a bayonet 520 for clamping the test strip is provided on each outer wall. The width of the bayonet 520 is the same or approximately the same as the width of the test strip, so that the test strip is just stuck in the bayonet 520 to avoid shaking of the test strip.
  • the width of the bottom of each sample containing cavity 500 or the entire sample containing cavity 500 is the same or approximately the same as the width of the test strip.
  • test strip when the test strip is inserted into the sample containing cavity 500, it is limited by the width limit, and the test strip is just stuck in the sample containing cavity 500.
  • the above arrangement is combined with the bayonet 520 on the outer wall. After the test strip is inserted into the sample accommodating cavity 500, both ends of the test strip are fixed, so that the test strip is not prone to shaking. The tilt angle can also be well controlled.
  • each sample containing cavity 500 may be designed to be higher than the inner wall, that is, the height of the outer wall of the cylindrical hollow cavity 510 is lower than the height of the outer wall of the cylinder.
  • the sample containing cavity 500 of this structure it is only necessary to fill each sample containing cavity 500 with liquid sample, and the excess liquid sample will overflow into the hollow cavity 510. Since the volume of each sample containing cavity 500 is the same, The volume of the liquid samples in the sample containing chambers 500 is the same. If each sample containing chamber 500 is not overflowed and filled, but instead contains a predetermined height of liquid sample, the predetermined height is limited by the user’s visual observation when it is poured. It is difficult to ensure that the volume of the liquid sample in each sample containing cavity 500 is the same, resulting in inaccurate detection results.
  • test strip uses a test strip to perform chromatographic detection on the sample in the sample containing cavity; the test strip includes at least a personalized mark area and a result display area.
  • the volume of the sample liquid in the multiple sample containing chambers is the same; the contact time of the test strip with the liquid sample in the sample containing chamber is the same; and the tilt angle of the test strip inserted into the sample containing chamber is the same.
  • the detection conditions of each test strip are basically the same during detection.
  • the purpose is to ensure that the test results of each test strip are stable under almost the same test conditions, and to avoid the detection results caused by different test conditions. Inaccuracy.
  • test strips after the tomographic test on a test disk provided with a marking block, and the test disk can arrange the test strips at an equal angle around the center of the test disk in the same circular area.
  • a test strip holding groove recessed downward from the upper surface of the test tray is provided on the test tray for holding the test strip.
  • the upper surface of the test strip is flush with the upper surface of the test tray.
  • the upper surface of the test strip is flush with the upper surface of the detection plate, which can reduce or avoid the height difference between the test strip and the test strip holding groove or the side wall of the test strip holding groove blocking the test.
  • the shadow caused by the part of the edge of the paper strip during image collection ensures the accuracy of image collection.
  • an isolation block for separating the lower surface of the test strip from the bottom of the test strip holding groove is provided at the bottom of the test strip holding groove.
  • the isolation block can separate the lower surface of the test strip from the bottom of the test strip holding groove, avoiding the test strip containing the sample solution from polluting the test strip holding groove, so that the test tray can be reuse.
  • the personalized mark area is made close to the center of the detection plate, and the test strip is The frame of the area containing the test strip in the holding slot matches the shape of the test strip.
  • the personalized mark area is close to the center of the detection disk, which facilitates the shooting of the personalized mark area and the color rendering area within a small shooting range, and the collected images are clearer.
  • Matching the border of the area containing the test strip in the test strip holding groove with the shape of the test strip is to avoid the border of the area containing the test strip in the test strip holding groove and the edge of the test strip The gap between them will form a shadow in the collected image, which will affect the correct reading of the personalized sign area information.
  • S304 Use the mobile terminal to perform image collection on the test disk and the test strip on it;
  • S305 Upload the collected image to the data processing center for data processing, and obtain the detection result of the target object;
  • the assembling manner of the sample containing cavity used in the method for simultaneously detecting multiple targets is only exemplary.
  • FIG. 4 is a flowchart of a synchronously detecting multiple targets according to an embodiment of the present disclosure.
  • the method for synchronously detecting multiple targets includes the following steps: including:
  • the liquid sample to be tested is contained in a plurality of sample containing cavities with dripping pipes at the bottom;
  • the multiple sample containing cavities in this embodiment are combined into a cylindrical shape, and the structure is the same as the assembling manner of the multiple sample containing cavities shown in FIG. 5, but is different from the structure shown in FIG. 5
  • the outer walls of the multiple sample containing cavities in the embodiment of the present disclosure are not provided with bayonet openings, but are provided with a dripping pipe at the bottom, and at the same time, a clamping column 540 adapted to the detection plate is also provided.
  • Fig. 6 is a bottom view of an assembling structure of a plurality of sample containing chambers according to an embodiment. See Figure 6.
  • a dripping pipe 530 is provided at the bottom of each sample containing cavity.
  • test strips Place test strips on a test tray provided with a marking block, where the test strips are arranged at an equal angle around the center of the test tray in a circular area of the test tray; the test strips include at least personality Chemical mark area, result display area, liquid suction area;
  • a test strip holding groove recessed downward from the upper surface of the test tray is provided on the test tray for holding the test strip.
  • the upper surface of the test strip is flush with the upper surface of the test tray.
  • the upper surface of the test strip is flush with the upper surface of the detection plate, which can reduce or avoid the height difference between the test strip and the test strip holding groove or the side wall of the test strip holding groove blocking the test.
  • the shadow caused by the part of the edge of the paper strip during image collection ensures the accuracy of image collection.
  • an isolation block for separating the lower surface of the test strip from the bottom of the test strip holding groove is provided at the bottom of the test strip holding groove.
  • the isolation block can separate the lower surface of the test strip from the bottom of the test strip holding groove, avoiding the test strip containing the sample solution from polluting the test strip holding groove, so that the test tray can be reuse.
  • the personalized mark area is made close to the center of the detection plate, and the test strip is The frame of the area containing the test strip in the holding slot matches the shape of the test strip.
  • the personalized mark area is close to the center of the detection disk, which facilitates the shooting of the personalized mark area and the color rendering area within a small shooting range, and the collected images are clearer.
  • Matching the border of the area containing the test strip in the test strip holding groove with the shape of the test strip is to avoid the border of the area containing the test strip in the test strip holding groove and the edge of the test strip The gap between them will form a shadow in the collected image, which will affect the correct reading of the personalized sign area information.
  • S403 Place the dripping pipes of the multiple sample accommodating cavities correspondingly above the liquid suction area of each test strip, so that the test strip performs chromatographic detection on the liquid sample in the sample accommodating cavity;
  • the volume of the sample liquid in the multiple sample containing chambers is the same; the contact time between the test strip and the liquid sample is the same; and the dripping pipe is placed at the same position above the liquid suction area of the test strip.
  • the detection conditions of each test strip are basically the same during detection.
  • the purpose is to ensure that the test results of each test strip are stable under almost the same test conditions, and to avoid the detection results caused by different test conditions. Inaccuracy.
  • S405 Upload the collected image to the data processing center for data processing, and obtain the detection result of the target object;
  • FIG. 7 is a schematic structural diagram of a system for detecting target components using a mobile terminal according to an embodiment.
  • the system for detecting target components using a mobile terminal includes:
  • the sample liquid detection device 710 includes a test strip and a test disk; the test strip includes at least a personalized mark area and a result display area; the test disk is used to limit the test strips to be arranged at equal angles around the same center of the circle to obtain the test Paper strip arrangement ring; the detection disc is also provided with a positioning mark for locating the position of the test strip in the test strip arrangement ring;
  • An image acquisition device 720 which is provided on the mobile terminal and is configured to perform image acquisition on the test strip arrangement ring;
  • the data processing device 730 is configured to perform data processing on the collected image and obtain the test result of the target component
  • the test result receiving device 740 is configured to receive the test result of the target component, and the test result receiving device is provided on the mobile terminal.
  • the system for detecting target components using a mobile terminal in this embodiment is used to perform the above-mentioned method for detecting target components using a mobile terminal; or the system is used to perform a method for detecting multiple targets simultaneously.
  • the image acquisition device 720 and the test result receiving device 740 may both be provided on the mobile terminal.
  • the data processing device may include:
  • the image correction unit 731 is configured to identify the positioning mark in the collected image and correct the collected image according to the positioning mark;
  • the image segmentation unit 732 is configured to segment the images of the personalized mark area and the result display area in each test strip;
  • the calculation unit 733 is configured to calculate the color rendering result of the result display area, and compare the color rendering result with the standard color rendering result in a pre-established standard database that matches the identity information in the personalized logo area To obtain the test result of the target component.
  • the correction method of the image correction unit can be referred to the correction method of the figure in the method of detecting the target component by using the mobile terminal, which will not be repeated here.
  • the data processing device settings may be set on the mobile terminal.
  • the data processing device may be provided on a remote terminal communicatively connected with the mobile terminal.
  • step (2) Put the color test strips in step (1) into the test strip holding slot of the test tray in accordance with the requirements of the operating specifications, and use the mobile terminal (mobile phone) to take pictures, and upload the pictures to the data processing center to obtain T/C value-mobile phone.
  • mobile terminal mobile phone
  • step (3) Place the color test strip in step (1) in the handheld food safety analyzer GT-710 to obtain the T/C value-instrument.
  • the method for detecting target components using a mobile terminal uses a circular array of test strips to arrange the test strips to identify the positioning marks in the image recognition process to segment the required test strips to obtain the chromaticity The value is compared with the chromaticity value of the corresponding standard database to obtain the test result.
  • This method omits the process of directly identifying the color area and reduces the recognition error in the width direction of the test strip due to inaccurate edge recognition. Big disadvantage; at the same time, this processing process can realize multi-channel detection, and can output reliable detection results for the test strip detection of each channel; in addition, this method is not affected by the type of mobile terminal, the tilt of the shooting angle, etc. The influence of factors has the characteristics of low requirements for the professionalism of operators, and the ability to perform qualitative and/or quantitative detection of targets anytime and anywhere under conventional ambient light conditions.
  • the method for synchronous detection of multiple targets only needs to perform the tomographic detection of the test strip, the placement of the test strip, the mobile terminal photographing, and the uploading system.
  • the test results can be obtained, the process is simple, and the operation is simple.
  • the difficulty is low, and it is easy to popularize, and realizes accurate measurement for the detection of target components of the sample liquid; at the same time, it can use the mobile terminal to realize the detection of multi-channel test strips.
  • the system for detecting target components using a mobile terminal only uses a sample liquid detection device and a mobile terminal equipped with an image acquisition device and a test result receiving device and a data processing device (which can be in the cloud or a mobile terminal).
  • the detection of the target component can be achieved, the device is simple, small in size, easy to carry, simple in operation, can be used at home, easy to market, and the test result is reliable.

Abstract

一种利用移动终端对目标成分进行检测的方法及系统，以及一种对多目标物同时筛查的检测方法。利用移动终端对目标成分检测的方法包括：使用试纸条（100）对目标成分进行检测，得到显色的试纸条（100）；将试纸条（100）绕同一圆心等角度排列，得到试纸条（100）排列环，其中，在试纸条（100）排列环上、试纸条（100）之外的区域设置有定位标识；使用移动终端对试纸条（100）排列环进行图像采集，并将采集图像上传至数据处理中心；根据定位标识对采集图像进行矫正；确定图像中每个试纸条（100）的个性化标志区和结果显示区的位置；分割每个试纸条（100）中个性化标志区和结果显示区的图像；计算结果显示区的显色结果，并获取目标成分的测试结果；输出目标成分的测试结果并在移动终端上显示。

Description

利用移动终端对目标成分进行检测的方法及系统
相关申请的交叉引用
本公开要求于2019年11月15日提交中国专利局的申请号为2019111260081、名称为“利用移动终端对目标成分进行检测的方法及系统”的中国专利申请的优先权，其全部内容通过引用结合在本公开中。
技术领域
本公开涉及免疫学检测技术领域，具体而言，涉及一种利用移动终端对目标成分进行检测的方法及系统，以及一种对多目标物同时筛查的检测方法。
背景技术
目前，目标物的快速检测通常采用免疫层析法来进行，免疫层析法多通过试纸条的形式来进行检测。试纸条种类不同，读取方式不同，增加了试纸条在非专业人群中的使用难度，无法满足人们对目标物进行实时检测的需求。
此外，即使对于专业人士，不同浓度的目标物会使试纸条上的测试线颜色深浅不同。通过肉眼观察试纸条的显色结果进行对目标物的定性或定量检测的判读，经常受到操作人员的个人主观因素影响，导致检测结果判定不准确。
现有技术为了排除个人主观因素的影响，大都采用设计试纸条读取仪进行试纸条的读取，试纸条读取仪具有特定位置特定强度的光源，同时具有特定位置的摄像头，且一般在暗盒中，拍摄图像后，显色区域相对固定，数据读取相对准确。但是试纸条读取仪携带不方便，价格较高，不适合普通消费者随时进行目标物检测。
因此，本领域需要提供一种对操作人员专业度要求不高，且能够随时随地在常规环境光条件下进行目标物的定性和/或定量检测的方法，同时检测结果具有较高的可靠性。
发明内容
本公开实施例的目的在于提供一种利用移动终端对目标成分进行检测的方法，其能够利用移动终端对多目标成分同时进行检测，且不受移动终端种类、拍摄角度倾斜等因素的影响，具有对操作人员专业度要求不高，能够随时随地在常规环境光条件下进行目标物定性和/或定量检测的特点。
本公开实施例提供一种利用移动终端对目标成分进行检测的方法，其包括：
使用试纸条对待测样品液进行检测，得到显色的试纸条；所述试纸条至少包括个性化标志区和结果显示区；
将试纸条绕同一圆心等角度排列，得到试纸条排列环；在所述试纸条排列环上、所述试纸条之外的检测盘区域设置有定位标识；
使用移动终端对试纸条排列环进行图像采集，并将采集图像上传至数据处理中心；
识别所述采集图像中的定位标识，并根据定位标识对采集图像进行矫正，根据所述定位标识与所述试纸条之间预先设定的位置关系确定矫正图像中每个试纸条的个性化标志区和结果显示区的位置，根据确定的每个试纸条的个性化标志区和结果显示区的位置进行图像分割，分割出每个试纸条中个性化标志区和结果显示区的图像；
计算结果显示区的显色结果，并将所述显色结果与预先建立的与该个性化标志区中的身份信息匹配的标准数据库中的标准显色结果比对，获取目标成分的测试结果；
输出目标成分的测试结果并在所述移动终端上显示。
在上述实现过程中，在每个试纸条上设置个性化标志区，个性化标志区上设置有用于识别其所在试纸条类别的身份信息。将试纸条绕同一圆心等角度排列，相对于非圆周阵列的试纸条组合会造成在拍摄时会由于近大远小而使不同试纸条的图像具有明显差别，本公开中的圆周排列能够使采集到的试纸条的图像畸变趋于相同。通过定位标识对采集到的试纸条的图像进行矫正，消除了在图像采集过程中由于抖动、角度倾斜等原因造成的图像畸变。基于试纸条图像几乎无畸变的情况下根据预先设定的位置关系得到每个试纸条图像中个性化标志区和结果显示区的精准位置，从而在对试纸条结果显示区域的图像处理过程中保证分割出的结果显示区域与实际的结果显示区域匹配度更高，进而在与匹配的标准数值比对后 即可得出更加准确的检测结果。由此可知，本公开中的方法对操作人员专业度要求不高，能够随时随地在常规环境光条件下进行目标物定性和/或定量的检测，同时检测结果具有较高的准确性。
在一种可能的实现方式中，所述根据定位标识对采集图像进行矫正包括：
拍摄角度的矫正和位置偏离的矫正。
在上述实现过程中，通过对采集图像进行矫正，可以使采集图像中的试纸条、定位标识等物体的位置、大小及摆放方向与实际物品的位置、大小及摆放方向相同或存在设定的比例关系，即可以实现图像与实际物品相同或等比例放大或缩小，在采用相同规格尺寸的试纸条时，矫正后的试纸条的图像的畸变基本相同，用于图像分割的结果显示区的面积基本一致，从而提高了结果显示区显色结果识别的准确性，为检测结果的可靠性提供保证。
在一种可能的实现方式中，所述根据定位标识对采集图像进行矫正包括：识别定位标识的位置和/或形状，根据所述定位标识的位置和/或形状对采集图像的拍摄角度进行矫正和/或对采集图像的位置偏离进行矫正。
定位标识具有与周围能够明显区别的特征(如形状、边界、位置、尺寸、颜色等)，通过对所述定位标识的特征进行识别，将其与数据处理中心的预定标识的特征进行匹配处理，从而实现对图像的矫正，矫正过程更准确，算法更简单。相较于直接对试纸条(或显色区)进行边缘识别，这种方法的定位标识的特征(尤其是边界)更清晰，识别更准确，矫正结果更准确，从而提高了显色结果识别的准确性，为检测结果的可靠性提供保证。
在一种可能的实现方式中，所述定位标识具有预定的形状，设置在预定的位置；
所述定位标识具有预定的形状和预定的位置，在图像识别时，数据处理中心可以根据预定的形状和预定的位置，对采集图像的定位标识进行形状和位置匹配，实现对采集图像的矫正。
在一种可能的实现方式中，所述定位标识的形状为具有明显的顶点和直边的形状。
定位标识识别过程中，明显的顶点和直边更容易识别，识别也更准确，能够提高图像矫正的准确性。
在一种可能的实现方式中，所述试纸条排列环通过将所述试纸条限位在检测盘上获得；所述定位标识为设置在所述检测盘上的标记块，和/或所述定位标识为所述检测盘的边缘；
所述定位标识是能够在数据采集过程中，对试纸条进行定位作用的标识，这些定位标识可以是明确的标记块，也可以是盛放试纸条的检测盘的某些结构特征(比如检测盘边缘等)。
可选地，所述标记块为设置在所述检测盘上的区别标记块和对比标记块。区别标记块和对比标记块用以对试纸条的摆放次序、位置等进行标记。
在一种可能的实现方式中，所述分割出每个试纸条中个性化标志区和结果显示区的图像包括：
识别所述采集图像中的标记块，并根据标记块对采集图像进行矫正，根据所述标记块与所述试纸条之间预先设定的位置关系确定矫正图像中每个试纸条的个性化标志区和结果显示区的位置，根据确定的每个试纸条的个性化标志区和结果显示区的位置进行图像分割，得到每个试纸条中个性化标志区和结果显示区的分割图像；
在另一种可能的实现方式中，所述分割出每个试纸条中个性化标志区和结果显示区的图像包括：
识别所述采集图像中的检测盘边缘，并根据检测盘边缘对采集图像进行矫正，根据所述检测盘边缘与所述试纸条之间预先设定的位置关系确定矫正图像中每个试纸条的个性化标志区和结果显示区的位置，根据确定的每个试纸条的个性化标志区和结果显示区的位置进行图像分割，得到每个试纸条中个性化标志区和结果显示区的分割图像；
在另一种可能的实现方式中，所述分割出每个试纸条中个性化标志区和结果显示区的图像包括：
识别所述采集图像中的标记块和检测盘边缘，并根据标记块和检测盘边缘对采集图像进行矫正，根据所述标记块和检测盘边缘的共同信息，以及其与所述试纸条之间预先设定的位置关系确定矫正图像中每个试纸条的个性化标志区和结果显示区的位置，根据确定的每个试纸条的个性化标志区和结果显示区的位置进行图像分割，得到每个试纸条中个性化标志区和结果显示区的分割图像。
上述，所述识别所述采集图像中的定位标识，并根据定位标识对采集图像进行矫正，分割出每个试纸条中个性化标志区和结果显示区的图像的实现方式可以理解为：对于采集图像的矫正可以仅通过标记块实现，也可以仅通过检测盘边缘实现，更可以通过标记块和检测盘边缘实现。通过标记块和检测盘边 缘实现的方式中，标记块的矫正结果和检测盘边缘的检测结果可以互相校对，从而提高图像矫正的准确性，提高显色区的识别精度和准确度，提高显色区的显色结果的读取准确性。
在一种可能的实现方式中，所述试纸条中结果显示区包括T线和C线；
所述显色结果为T线图像色度值与C线图像色度值的比值；或所述显色结果为T线图像的色度值，所述色度值包括RGB值、灰度值或光度值。
在一种可能的实现方式中，计算所述显色结果为T线图像色度值与C线图像色度值的比值时，包括：
使T线图像相对于背景色的色度值与C线图像相对于背景色的色度值的比值作为所述显色结果；
可选地，所述背景色的选取区域位于所述结果显示区中的T线附近或者C线附近；
可选地，所述背景色的选取区域位于T线和C线之间。
在一种可能的实现方式中，在所述使用试纸条对目标成分进行检测时，包括：
将试纸条分别放置于盛放有目标成分的多个样品容纳腔中，多个样品容纳腔中的样品液量相同；试纸条放入所述样品容纳腔中的倾斜角度相同，放入时间相同。
在上述实现过程中，将试纸条按照相同的角度，在相同体积的样品液中进行层析检测，层析行为一致，能够减少操作误差带来的显色结果的差别，提高显色结果的可靠性。
在一种可能的实现方式中，所述利用移动终端对目标成分进行检测的方法还包括：通过所述标记块对所述试纸条排列环中试纸条的次序进行标定；
可选地，以能够与其余标记块进行区别的一个标记块为次序起点，按顺时针方向或逆时针方向依次为所述试纸条排列环中的试纸条进行排序。
在一种可能的实现方式中，所述移动终端的图像采集设备的像素至少为800万。
本公开实施例还提供了一种对多目标物同步进行检测的方法，包括：
将待测液体样品液盛装在多个样品容纳腔内；
使用试纸条对样品容纳腔内的样品进行层析检测；所述试纸条至少包括个性化标志区和结果显示区；
将层析检测后的试纸条放置在设置有定位标识的检测盘上，所述检测盘能够使所述试纸条在同一圆环区域内绕检测盘的中心等角度排列；
利用移动终端对检测盘及其上的试纸条进行图像采集；
将采集图像上传至数据处理中心进行数据处理，识别所述采集图像中的定位标识，并根据定位标识对采集图像进行矫正，根据所述定位标识与所述试纸条之间预先设定的位置关系确定矫正图像中每个试纸条的个性化标志区和结果显示区的位置，根据确定的每个试纸条的个性化标志区和结果显示区的位置进行图像分割，得到每个试纸条中个性化标志区和结果显示区的分割图像，获得目标物的检测结果；
向移动终端返回目标物的检测结果。
本公开实施例还提供了一种对多目标物同步进行检测的方法，包括：
将待测液体样品液盛装在多个底部开有滴液管路的样品容纳腔内；
将试纸条放置在设置有定位标识的检测盘上，所述试纸条在所述检测盘的一个圆环区域内绕检测盘的中心等角度排列；所述试纸条至少包括个性化标志区、结果显示区、液体吸取区；
将多个样品容纳腔的滴液管路对应放置在每个试纸条液体吸取区的上方，以使试纸条对样品容纳腔内的液体样品进行层析检测；
在试纸条层析完毕后利用移动终端对检测盘及其上的试纸条进行图像采集；
将采集图像上传至数据处理中心进行数据处理，识别所述采集图像中的定位标识，并根据定位标识对采集图像进行矫正，根据所述定位标识与所述试纸条之间预先设定的位置关系确定矫正图像中每个试纸条的个性化标志区和结果显示区的位置，根据确定的每个试纸条的个性化标志区和结果显示区的位置进行图像分割，得到每个试纸条中个性化标志区和结果显示区的分割图像，获得目标物的检测结果；
向移动终端返回目标物的检测结果。
在一种可能的检测方式中，所述检测盘上表面设置的定位标识为标记块，用于在图像采集处理过程 中，对试纸条进行定位标记。
标记块也能够起到对图像进行矫正的作用，同时利用检测盘的边缘和检测块进行检测，能够提高图像矫正的准确度。
可选地，所述标记块包括区别标记块和对比标记块；所述区别标记块用于与所述对比标记块进行区别。
可选地，所述区别标记块与所述对比标记块的总个数不少于三个。
区别标记块和对比标记块能够实现对试纸条排列顺序的标记。三个以上的标记块能够更好的矫正拍摄角度。
可选地，所述标记块的形状至少包括顶点和直边。
具有顶点和直边的标记块，更容易被识别定位，从而实现图像的准确矫正。
可选地，所述标记块为一个蓝色正方形色块和三个绿色正方形色块，或者所述标记块为一个绿色正方形色块和三个蓝色正方形色块。
蓝色、绿色、黄色为稳定的颜色，在对标记边缘识别时，不易受环境光的影响，识别结果更准确。
在一个具体实现方式中，所述检测盘上表面为正多边形。
正多边形具有明确的顶点和边，在图像处理时更容易被识别，并与数据处理中心预设的形状匹配，即图像矫正更准确。
可选地，所述检测盘的上表面为中性色表面。
可选地，所述检测盘的上表面为漫反射表面。
中性色表面受到外界光源的影响较小，且其反射光对显色区域的颜色干扰小，在数据读取时，显色结果读取更准确。漫反射表面不会出现光源反射的光斑，造成对图像采集的干扰。
在一种可能的实现方式中，在试纸条对样品容纳腔内的样品进行层析检测时，多个样品容纳腔中的样品液量相同；所述试纸条与所述样品容纳腔中的液体样品接触时间相同。
相同的测试条件，能够降低操作误差带来的显色结果误差。
可选地，在所述试纸条插入所述样品容纳腔内时，所述试纸条插入所述样品容纳腔的倾斜角度相同。
对于先进行试纸条层析检测样品液步骤，然后再将所述试纸条排列成圆周方式，试纸条的插入角度也是操作的可变因素，相同的试纸条插入角度同样能够降低操作误差带来的结果显示误差。
可选地，在所述试纸条位于所述样品容纳腔底部时，滴液管路放置在试纸条液体吸取区上方的位置相同。
对于直接将试纸条排列成圆周方式，将样品容纳腔的样品液通过漏液方式进行试纸条的层析检测的方式，样品液在试纸条上的接触位置也是操作的可变因素，相同的样品液接触位置同样能够降低操作误差带来的结果显示误差。
在一种可能的实现方式中，在将所述试纸条放置到所述检测盘上后，所述试纸条的上表面与所述检测盘的上表面齐平。
可选地，所述结果显示区的上表面与所述检测盘的上表面齐平。
所述试纸条的上表面(尤其是试纸条结果显示区的上表面)与所述检测盘的上表面齐平，能够减少光源照射导致的阴影，提高数据处理过程中显色区域的色度识别准确度，提高检测结果的准确性。
在一种可能的实现方式中，所述移动终端的图像采集设备的像素至少为800万。
像素越高，对定位标识的识别精度越高，图像矫正准确性越高，显色区域分割越准确，显色结果识别越准确，检测结果越可靠。
在一种可能的实现方式中，在所述检测盘上设置自所述检测盘上表面向下凹陷的试纸条盛放槽，用于盛放所述试纸条。
试纸条盛放槽能够起到对试纸条进行限位的作用，避免试纸条因为放置角度等问题出现滑动等。
可选地，在所述试纸条盛放槽的底部设置用以将所述试纸条的下表面与所述试纸条盛放槽的底部分离的隔离块。
隔离块能够将试纸条与试纸条盛放槽底部分离，防止试纸条上的样品液污染试纸条盛放槽，减少连续样品检测时的样品污染，提高结果准确性。
可选地，在将所述试纸条放入所述试纸条盛放槽时，使所述个性化标志区靠近所述检测盘的圆心，并使所述试纸条盛放槽中容纳试纸条的区域的边框与试纸条的形状匹配。
所述试纸条盛放槽中容纳试纸条的区域的边框与试纸条的形状匹配，能够减少试纸条与试纸条盛放槽的缝隙，避免被数据处理中心识别为个性化标志区的个性化标志的一部分，影响标准数据库的选取；同时也可以避免缝隙阴影对结果显色区T线和C线识别的干扰。
本公开实施例还提供了一种利用移动终端对目标成分进行检测的系统，包括：
样品液检测装置，包括试纸条和检测盘；所述试纸条至少包括个性化标志区和结果显示区；所述检测盘用于限定试纸条绕同一圆心等角度排列，以得到试纸条排列环；所述检测盘上还设有用于图像采集后用于定位所述试纸条排列环中试纸条位置的定位标识；
图像采集装置，设置在所述移动终端上，被配置用于对试纸条排列环进行图像采集；
数据处理装置，被配置用于对采集到的图像进行数据处理，识别采集到的图像中的定位标识，并根据定位标识对采集图像进行矫正，根据所述定位标识与所述试纸条之间预先设定的位置关系确定矫正图像中每个试纸条的个性化标志区和结果显示区的位置，根据确定的每个试纸条的个性化标志区和结果显示区的位置进行图像分割，得到每个试纸条中个性化标志区和结果显示区的分割图像，并获得目标成分的测试结果；
测试结果接收装置，被配置用于接收目标成分的测试结果，所述测试结果接收装置设置在所述移动终端上。
所述的利用移动终端对目标成分进行检测的系统，搭载的装置简单，样品液检测装置体积小，易携带，图像采集装置、数据处理装置、测试结果接收装置可以搭载在移动终端或云端，降低了操作难度，使目标成分的检测方法的推广更加便捷。此外，所述的利用移动终端对目标成分进行检测的系统能够实现多通道检测，检测结果可靠。
在一种可能的实现方式中，所述系统用于进行本公开实施例提供的利用移动终端对目标成分进行检测的方法；或者所述系统用于进行本公开实施例提供的对多目标物同步进行检测的方法。
所述的利用移动终端对目标成分进行检测的系统可以进行不同方式的检测，优选用于进行本公开实施例提供的利用移动终端对目标成分进行检测的方法；或者进行本公开实施例提供的对多目标物同步进行检测的方法。
在一种可能的实现方式中，所述数据处理装置包括：
图像矫正单元，被配置用于识别采集图像中的定位标识并根据定位标识对采集图像进行矫正；
图像分割单元，被配置用于分割每个试纸条中个性化标志区和结果显示区的图像；
计算单元，被配置用于计算结果显示区的显色结果，并将所述显色结果与预先建立的与该个性化标志区中的身份信息匹配的标准数据库中的标准显色结果比对，获取目标成分的测试结果。
所述的数据处理装置的各个部件能够实现对采集图像的矫正，解决移动终端采集图像千差万别，识别结果不准确的问题；结合分割单元，实现对所需区域(个性化标志区和结果显示区)的准确分割；可选地，结合计算单元，实现对准确分割的显色区域的显色结果的读取。
可选地，所述数据处理装置是本公开提供的利用移动终端对目标成分进行检测的系统数据处理装置的一种实现方式，本领域技术人员可以选择任意的能够对移动终端拍摄的图像进行数据处理，获得可靠测试结果的数据处理中心的任意实现方式。
在一种可能的实现方式中，所述数据处理装置设置在所述移动终端上；或者所述数据处理装置设置在与所述移动终端通信连接的远程终端上。
与发明人知晓的技术相比，本公开具有如下有益效果：
(1)本公开提供了一种利用移动终端对目标成分进行检测的方法，利用圆周阵列的试纸条排布方式，通过在图像识别过程中识别定位标识，分割出需要的试纸条区域，获得色度值，从而与对应的标准数据库的色度值比较，获得测试结果。这种方式省略了直接进行显色区识别的过程，降低了由于边缘识别不准确，导致的试纸条宽度方向识别误差较大的劣势；同时，这种处理过程能够实现多通道检测，且对于每一个通道的试纸条的检测都能够输出可靠的检测结果。
(2)本公开提供了一种对多目标物同步进行检测的方法，仅需要进行试纸条的层析检测、试纸条摆放、移动终端拍照，上传系统，既可以获得测试结果，过程简单，操作难度低，易于推广，为样品液的目标成分检测实现准确测量；同时能够利用移动终端实现多通道试纸条的检测。
(3)本公开还提供了一种利用移动终端对目标成分进行检测的系统，仅使用样品液检测装置和搭载有图像采集装置、测试结果接收装置的移动终端和数据处理装置(可在云端或移动终端)即可以实现的目标成分的检测，装置易携带，可实现家庭使用，易于市场化推广，测试结果可靠。
附图说明
为了更清楚地说明本公开实施例的技术方案，下面将对实施例中所需要使用的附图作简单地介绍，应当理解，以下附图仅示出了本公开的某些实施例，因此不应被看作是对范围的限定，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他相关的附图。
图1为本公开实施例提供的一种利用移动终端对目标成分进行检测的流程图；
图2为根据一种实施例示出的检测盘及试纸条排列在检测盘上的结构示意图；
图3为本公开实施例提供的一种对多目标物同步进行检测的流程图；
图4为本公开实施例提供的一种对多目标物同步进行检测的流程图；
图5为根据一种实施例示出的多个样品容纳腔拼装的结构示意图；
图6为根据一种实施例示出的多个样品容纳腔拼装结构的仰视图；
图7为根据一种实施例示出的利用移动终端对目标成分进行检测的系统的结构示意图。
附图标记：试纸条100、检测盘200、区别标记块300、对比标记块400、样品容纳腔500、中空腔体510、卡口520、滴液管路530、卡柱540、样品液检测装置710、图像采集装置720、数据处理装置730、图像矫正单元731、图像分割单元732、计算单元733、测试结果接收装置740
具体实施方式
为使本公开实施例的目的、技术方案和优点更加清楚，下面将结合本公开实施例中的附图，对本公开实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例是本公开的一部分实施例，而不是全部的实施例。通常在此处附图中描述和示出的本公开实施例的组件可以以各种不同的配置来布置和设计。
因此，以下对在附图中提供的本公开的实施例的详细描述并非旨在限制要求保护的本公开的范围，而是仅仅表示本公开的选定实施例。基于本公开中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例，都属于本公开保护的范围。
应注意到：相似的标号和字母在下面的附图中表示类似项，因此，一旦某一项在一个附图中被定义，则在随后的附图中不需要对其进行进一步定义和解释。
本公开通过免疫学检测技术实现，故在本公开实施例中所述的方法及系统均会采用试纸条来进行免疫学检测。
本公开实施例中的试纸条至少包括用于滴加样品液的样品垫，样品垫错位叠加胶体金垫，所述胶体金垫与所述样品垫交错的地方设置MAX线，所述胶体金垫另一端搭接硝酸纤维素膜，在所述硝酸纤维素膜另一端搭接吸水材料。所述硝酸纤维素膜上设置有T线(检测线)和C线(质控线)。用于对样品液中的目标物进行显色反应。所述试纸条中，T线和C线会根据样品液中目标物的含量呈现不同的颜色，通过读取试纸条T线和C线的颜色比值，获取样品液中目标物的含量。在所述试纸条中，样品垫和胶体金垫部分可以覆盖个性化标志得到个性化标志区，吸水材料部分也可以覆盖个性化标志得到个性化标志区：硝酸纤维素膜的区域为结果显色区。
本公开实施例中的试纸条至少包括个性化标志区、结果显示区和毛细区。毛细区用于将液态样品吸附至试纸条中并使液体样品进入设置胶体金层的区域以进行显色反应，显色后的测试结果在结果显示区呈现。通常试纸条的结果显示区设置T线(检测线)和C线(质控线)，显色反应可以只通过T线的显色反应获取检测结果，也可通过T线和C线两者的显色结果结合获取检测结果。个性化标志区用于设置身份信息，身份信息包括但不限于该试纸条的种类、品牌、出厂批号等信息。同时，标识信息为可识别的信息，如二维码、条形码等。在本公开实施例中，个性化标志区可以设置在除结果显示区之外的任 何区域，其不遮挡结果显示区即可。
在进行目标成分检测之前，需为每类试纸条事先建立标准数据库，在标准数据库中，将显色反应结果和目标成分的含量之间建立映射关系。
典型但非限制性的显色反应结果和目标成分的含量之间的映射关系是外标法，即选择现有已知浓度的目标成分的样品液进行现有特定个性化标志的试纸条的层析检测，然后采用本公开提供的方法进行层析检测试纸的显色结果和浓度的对应关系，具体的是将现有已知浓度的目标成分的样品液采用S101～S106、S301～S306或S401～S406中的任一操作进行检测，获得与所述目标成分浓度匹配的显色结果。
下面对如何实现对目标成分的检测进行详细阐述。
图1为本公开实施例提供的一种利用移动终端对目标成分进行检测的流程图。参见图1，利用移动终端对目标成分进行检测的方法包括如下步骤：
S101：使用试纸条对目标成分进行检测，得到显色的试纸条。
在一种实施方式中，采用试纸条对目标成分进行检测可以包括利用不同种类试纸对对应目标物进行检测，例如，采用尿液试纸条检测尿液样品，采用血液试纸条检测血液样品等；也可以为样品液相同，但筛查样品液中的多种成分，如筛查同一茶叶样品液中的多种农药残留、真菌毒素、环境污染物等。
在另一种实施方式中，采用试纸条对目标成分进行检测可以包括利用同类型试纸条对不同样品的同一目标物进行检测。如对不同茶水中的戊唑醇(农药残留物中的一种)进行检测。
可选地，本公开中试纸条的种类可以包括但不限于农药残留成分测试试纸条、医用领域中所用到的各类试纸条、环境污染成分测试用试纸条等。
S102：将试纸条绕同一圆心等角度排列，得到试纸条排列环；在所述试纸条排列环上、所述试纸条之外的区域设置有定位标识。
在一种可能的实现方式中，试纸条排列环可以通过将所述试纸条限位在检测盘上获得。图2为根据一种实施例示出的检测盘及试纸条排列在检测盘上的结构示意图。参见图2，试纸条100绕检测盘200的中心等角度排列。如图所示，检测盘200是六边形检测盘，六边形检测盘内放置六个试纸条100，每个试纸条100的一端靠近检测盘200的一个角，并且每个试纸条朝向检测盘200的中心延伸，使得每个试纸条的另一端靠近检测盘的中心；试纸条100的长度及检测盘200的大小设置成使得每个试纸条的靠近检测盘的中心的端部与检测盘的中心间隔开且每个试纸条的靠近检测盘的中心的端部彼此隔开。可选地，上述六边形检测盘及试纸条的排列方式仅是示例性的，本公开对于检测盘的形状及试纸条的排列方式不做具体限定，可以采用其它形状的检测盘及其它试纸条排列方式。
在将试纸条限位在检测盘上的一种实施方式可以为，在检测盘上设置用于容置试纸条的试纸条盛放槽，在试纸条被限位在试纸条盛放槽时，试纸条的上表面可选地与检测盘的上表面齐平。
可选地，采用试纸条盛放槽来对试纸条进行限位只是示例性的，还可以通过其他限位结构对试纸条进行限位，如通过柱形或多棱柱形限位块、限位挡板、限位插槽等结构中的任意一种或至少两种的组合来对试纸条进行限定，本公开对于限位结构不做具体限定，凡是能够在检测盘上实现将试纸条等角度排列成试纸条排列环的结构均落入本公开的保护范围。
在一种可能的实现方式中，定位标识可以为设置在检测盘200上的标记块，参见图2，标记块可以为设置在检测盘200上的区别标记块300和对比标记块400。区别标记块300用于与对比标记块400进行区别。在一种可能的实现方式中，标记块的形状至少可以包括顶点和直边。参见图2，标识块的形状为正方形块。标识块的上表面为正方形。可选地，标识块上表面的形状还可以为其他正多边形或带有顶点和直边的规则图形，本公开对于标识块上表面的形状不做具体限定，但以包括顶点和直边的规则图形为优选，如多边形或者正多边形、五角星形等。
在标识块的一种具体实施方式中，区别标记块300和对比标记块400的上表面面积可以相等，且区别标记块300和对比标记块400可以共同绕检测盘200的中心圆周阵列并靠近检测盘的外边缘设置。
在标识块的一种具体实施方式中，将区别标记块300和对比标记块400设置在所述检测盘的外边缘能够使所述标记块尽可能地远离检测盘的中心位置，采集到的每个标识块的图像清晰度更高，在对拍摄的图像进行识别时，能够通过标记块将图片的角度、位置进行更准确的矫正。
在标识块的一种具体实施方式中，区别标记块300和对比标记块400的几何中心连线可以围成正方形区域，所述正方形区域的中心与所述检测盘的中心重合。该设计方案能够简化矫正算法，提高数据处理中心的信息容纳量和处理速度。
在标识块的一种具体实施方式中，所述区别标记块300的上表面为一个蓝色正方形，对比标记块400的上表面为三个绿色正方形；或者区别标记块300的上表面为一个绿色正方形，对比标记块400的上表面为三个蓝色正方形。
在上述实现过程中，蓝色和绿色是色度比较稳定的颜色，受环境光亮度影响较小，在边界识别时精度更高，有利于采集图像的准确矫正。
可选地，上述实施例中示出的对于标识块的形状、颜色、排布位置等方案只是示例性的，本公开对于标识块的形状、颜色、排布位置等不做具体限定，凡是能够对采集图像中的待检试纸条的图像，尤其是试纸条显色区的图像能够进行矫正的识别特征均落入本公开的保护范围。
在另一种可能的实现方式中，定位标识可以为检测盘200的边缘，在图2所示的检测盘200中，即六边形检测盘的六条边。在再一种可能的实现方式中，定位标识可以为标记块和检测盘200的边缘两者的组合。
可选地，本公开对于检测盘200的边缘形状不做具体限定，但作为优选实施方式，检测盘200的边缘亦为包括顶点和直边的规则图形。
S103：使用移动终端对试纸条排列环进行图像采集，并将采集图像上传至数据处理中心。
本公开实施例中的移动终端可以包括但不限于手机、笔记本、平板电脑、POS机，甚至包括车载电脑等。凡是具备图像采集装置的终端均可以落入本公开的保护范围。
在一种可能的实现方式中，移动终端的图像采集设备的像素至少为800万(例如900万、1000万、1200万、1500万、1600万、1800万、2000万、2300万、2800万、3500万、40000万等)。
移动终端的图像采集设备的像素越高，其获取的图像的分辨率会越高，图像的识别精度亦越高，根据图像获取的检测结果亦会更准确。
S104：识别所述采集图像中的定位标识，并根据定位标识对采集图像进行矫正，分割出每个试纸条中个性化标志区和结果显示区的图像。
在一种可能的实现方式中，在识别出采集图像中的定位标识后，根据定位标识对采集图像进行矫正，具体为：根据所述定位标识与试纸条之间预先设定的位置关系，确定矫正图像中每个试纸条的个性化标志区和结果显示区的位置。可选地，定位标识与试纸条之间预先设定的位置关系可以为预先设置好的位置关系，或者受限于试纸条和与其对应的装置之间的既定位置关系。以试纸条限定在检测盘上为例，检测盘中用于盛放试纸条的位置和检测盘上的定位标识的关系为固定关系，在图像处理过程中，定位标识与试纸条之间的关系即为检测盘中试纸条与定位标识之间的既定位置关系，因为试纸条中，结果显示区和个性化标志区位于试纸条中的位置亦为既定位置关系。
在定位标识为检测盘上的检测块时，对采集图像进行矫正的方法为：根据标记块与所述试纸条之间预先设定的位置关系确定矫正图像中每个试纸条的个性化标志区和结果显示区的位置。
在定位标识为检测盘的边缘时，对采集图像进行矫正的方法为：根据检测盘的边缘与试纸条之间预先设定的位置关系确定矫正图像中每个试纸条的个性化标志区和结果显示区的位置。
在定位标识为检测盘上的检测块和检测盘的边缘时，对采集图像进行矫正的方法为：根据标记块与所述检测盘的边缘之间预先设定的位置关系确定检测盘边缘的位置；以及根据检测盘的边缘与试纸条之间预先设定的位置关系确定矫正图像中每个试纸条的个性化标志区和结果显示区的位置。
在确定每个试纸条的个性化标志区和结果显示区的位置后进行图像分割，得到每个试纸条中个性化标志区和结果显示区的分割图像。
可选地，通过上述预先设定的位置关系确定个性化标志区和结果显示区的位置只是示例性的，本公开对于通过何种位置关系来确定个性化标志区和结果显示区的位置不做具体限定。
S105：计算结果显示区的显色结果，并将显色结果与预先建立的与该个性化标志区中的身份信息匹配的标准数据库中的标准显色结果比对，获取目标成分的测试结果。
本公开实施例中，在进行检测前，已事先为每类试纸条建立标准数据库，在标准数据库中，显色结 果和目标成分的含量形成映射关系。在一种可能的实现方式中，显示结果通常采用T/C对比曲线来显示显色结果和目标成分含量之间的映射关系。若试纸条为消线法类试纸条，则通常采用T线图像色度值来显示显色结果和目标成分含量之间的映射关系。
在得到显色结果后，在T/C对比曲线或T值直线图中，查找与该显色结果对应的目标物浓度值。
在利用T线图像色度值和C线图像色度值的比值结果作为显色结果时，需计算T线图像的色度值和C线图像的色度值，可选地，色度值可以包括但不限于RGB值、灰度值或光度值。
在一种可能的实现方式中，计算显色结果为T线图像色度值与C线图像色度值的比值时，可以包括：
使T线图像相对于背景色的色度值与C线图像相对于背景色的色度值的比值作为所述显色结果。可选地，背景色的选取区域可以位于所述结果显示区中的T线附近或者C线附近。由于显色结果主要是T线和C线的色度比值，如果背景色选取离T线和C线距离过远，则背景噪音选取不准确，影响显色结果读取准确性。背景色选在结果显色区中T线和C线附近，一方面都在结果显色区材质基本相同，对光线的反射行为一致，另一方面距离较近，背景去燥效果更好。
可选地，背景色的选取区域可以位于T线和C线之间。T线和C线公用一个背景色进行去燥，比色结果更可靠。
在上述实现过程中，以T线与C线中间预定区域的图像作为背景色，其优点在于，T线图像色度值和C线图像色度值的比值会更加准确，其原因在于，试纸条在检测过程中可能会层析到其他干扰色，或者在图像拍摄过程中受到环境光的影响，对于同一个试纸条，层析或者在同一拍摄条件下结果显示区的背景色是一致的，以采集图像中试纸条的T线与C线中间预定区域的图像的色度值为背景色，相当于过滤掉干扰色对T线图像和C线图像色度值的干扰。由此可知，该计算方法不受其他干扰色的影响，使显色结果的计算更加准确。
S106：输出目标成分的测试结果并在移动终端上显示。
对于免疫层析的试纸条，进行样品层析检测后，经常出现显色区的显色不均匀的问题，因此准确获取显色区的显色结果成为获得可靠检测结果的重要一环，而通过移动终端和数据处理来获取显色结果的方式中，准确分割显色区的图像又是获得准确的显色结果的必要条件。相对于非圆周阵列的试纸条组合，将试纸条绕同一圆心等角度排列，能够在图像被矫正后，使每根试纸条具有相同的畸变程度，而非圆周阵列的试纸条组合，在图像被矫正后，不同试纸条之间仍然存在畸变差异，导致显色区的大小不同，而影响显色结果的读取的问题。
基于矫正后的图像中，每根试纸条畸变相同的情况下，根据预先设定的位置关系得到每个试纸条图像中个性化标志区和结果显示区的精准位置，从而在对试纸条进行图像分割时，能够使分割出的结果显示区域与实际的结果显示区域匹配度更高，从而提高显色结果的读取准确性，进而提高检测结果的准确性。
由此可知，本公开实现了利用移动终端对多目标成分同时进行检测的目的，操作难度低，操作设备方便携带，能够实现随时检测，且检测结果可靠。同时能够进行多通道的检测，并且多通道的检测结果均比较可靠。
可选地，目标成分的测试结果可以输出在用于图像采集的移动终端上，也可以输出在任何一个与数据处理中心能够进行数据传输的移动终端上，也可以输出在数据处理中心的数据存储部，进行数据的存储，以供随时调取。
根据本发明的实现方式，还提供了一种对多目标物同步进行检测的方法。图3为本公开实施例提供的一种对多目标物同步进行检测的流程图。参见图3，对多目标物同步进行检测的方法包括如下步骤：
S301：将待测液体样品液盛装在多个样品容纳腔内。
在一种可能的实现方式中，多个样品容纳腔可以组合成圆柱形。图5为根据一种实施例示出的多个样品容纳腔拼装的结构示意图。参见图5，多个样品容纳腔500一体成型，围合成一个中间具有中空腔体510的圆柱体，每个样品容纳腔500均包括一个用于围成圆柱体外边的外壁，和一个用于围成中间空腔的内壁。在一种优选的实施方式中，在每个外壁上开设一个用于卡设试纸条的卡口520。卡口520的宽度与试纸条的宽度相同或近似相同，以使试纸条刚好卡在卡口520内，避免试纸条发生晃动。
在一种可能的实现方式中，每个样品容纳腔500底部或者整个样品容纳腔500的宽度(该宽度方向 与圆柱体的半径方向垂直)与试纸条的宽度相同或近似相同。
在上述实现过程中，试纸条在插入样品容纳腔500时，受限于宽度限位，试纸条刚好卡在样品容纳腔500内。上述设置与外壁上的卡口520设置结合，则试纸条在插入样品容纳腔500后，试纸条的两端均进行固定，从而使试纸条不易发生晃动，进一步地，试纸条的倾斜角度亦可以进行很好的控制。
在一种可能的实现方式中，每个样品容纳腔500的外壁可以设计成高于内壁，即圆柱体中空腔体510的外壁高度低于圆柱体外壁的高度。使用该结构的样品容纳腔500时，只需将每个样品容纳腔500加满液体样品，多余的液体样品会溢流至中空腔体510内，由于每个样品容纳腔500的体积相同，故样品容纳腔500内的液体样品的体积相同，若每个样品容纳腔500不溢满盛放，而是盛放预定高度的液体样品，由于预定高度受限于使用者在倾倒时的肉眼观察，很难保证每个样品容纳腔500内的液体样品体积相同，导致检测结果不准确。
S302：使用试纸条对样品容纳腔内的样品进行层析检测；所述试纸条至少包括个性化标志区和结果显示区。
在一种可能的实现方式中，多个样品容纳腔中的样品液体积相同；试纸条与样品容纳腔中的液体样品接触时间相同；试纸条插入所述样品容纳腔的倾斜角度相同。
在上述实现过程中，每个试纸条在检测时的检测条件基本相同，其目的是在保证几乎相同的检测条件下，每个试纸的检测结果稳定，避免由于不同的检测条件导致检测结果的不准确性。
S303：将层析检测后的试纸条放置在设置有标记块的检测盘上，所述检测盘能够使所述试纸条在同一圆环区域内绕检测盘的中心等角度排列。
在一种可能的实现方式中，在检测盘上设置自所述检测盘上表面向下凹陷的试纸条盛放槽，用于盛放所述试纸条。
在一种可能的实现方式中，在将所述试纸条放置到所述检测盘上后，所述试纸条的上表面与所述检测盘的上表面齐平。
在上述实现过程中，试纸条的上表面与检测盘上表面齐平，能够减少或避免试纸条与试纸条盛放槽之间由于高度差或试纸条盛放槽侧壁遮挡试纸条的部分边缘而造成的图像采集时产生的阴影，保证图像采集的准确性。
在一种可能的实现方式中，在试纸条盛放槽的底部设置用以将试纸条的下表面与试纸条盛放槽的底部分离的隔离块。
在上述实现过程中，隔离块可以使试纸条的下表面与试纸条盛放槽的底部分离，避免层析了样品液的试纸条污染试纸条盛放槽，从而使检测盘得以重复使用。
在一种可能的实现方式中，在将所述试纸条放入所述试纸条盛放槽时，使所述个性化标志区靠近所述检测盘的圆心，并使所述试纸条盛放槽中容纳试纸条的区域的边框与试纸条的形状匹配。
在上述实现过程中，个性化标志区靠近所述检测盘的圆心，便于在较小的拍摄范围内即可实现对个性化标志区和显色区的拍摄，采集到的图像更加清晰。使所述试纸条盛放槽中容纳试纸条的区域的边框与试纸条的形状匹配，是为了避免试纸条盛放槽中容纳试纸条的区域的边框与试纸条的边缘之间的缝隙会在采集到的图像中形成阴影，进而影响个性化标志区信息的正确读取。
S304：利用移动终端对检测盘及其上的试纸条进行图像采集；
S305：将采集图像上传至数据处理中心进行数据处理，获得目标物的检测结果；
S306：向移动终端返回目标物的检测结果。
可选地，上述对多目标物同步进行检测的方法中所使用的样品容纳腔的拼装方式只是示例性的。
根据本发明的再一方面，还提供了一种对多目标物同步进行检测的方法，图4为本公开实施例提供的一种对多目标物同步进行检测的流程图。参见图4，对多目标物同步进行检测的方法包括如下步骤：包括：
S401：将待测液体样品液盛装在多个底部开有滴液管路的样品容纳腔内；
在一种可能的实现方式中，本实施例中的多个样品容纳腔组合成圆柱形，其结构与图5所示的多个样品容纳腔的拼装方式相同，但与图5所示结构不同的是，本公开实施例中的多个样品容纳腔的外壁不设置卡口，而是在底部设有滴液管路，同时还设置有与检测盘适配的卡柱540。图6为根据一种实施例 示出的多个样品容纳腔拼装结构的仰视图。参见图6。每个样品容纳腔的底部设有滴液管路530。
S402：将试纸条放置在设置有标记块的检测盘上，所述试纸条在所述检测盘的一个圆环区域内绕检测盘的中心等角度排列；所述试纸条至少包括个性化标志区、结果显示区、液体吸取区；
在一种可能的实现方式中，在检测盘上设置自所述检测盘上表面向下凹陷的试纸条盛放槽，用于盛放所述试纸条。
在一种可能的实现方式中，在将所述试纸条放置到所述检测盘上后，所述试纸条的上表面与所述检测盘的上表面齐平。
在上述实现过程中，试纸条的上表面与检测盘上表面齐平，能够减少或避免试纸条与试纸条盛放槽之间由于高度差或试纸条盛放槽侧壁遮挡试纸条的部分边缘而造成的图像采集时产生的阴影，保证图像采集的准确性。
在一种可能的实现方式中，在试纸条盛放槽的底部设置用以将试纸条的下表面与试纸条盛放槽的底部分离的隔离块。
在上述实现过程中，隔离块可以使试纸条的下表面与试纸条盛放槽的底部分离，避免层析了样品液的试纸条污染试纸条盛放槽，从而使检测盘得以重复使用。
在一种可能的实现方式中，在将所述试纸条放入所述试纸条盛放槽时，使所述个性化标志区靠近所述检测盘的圆心，并使所述试纸条盛放槽中容纳试纸条的区域的边框与试纸条的形状匹配。
在上述实现过程中，个性化标志区靠近所述检测盘的圆心，便于在较小的拍摄范围内即可实现对个性化标志区和显色区的拍摄，采集到的图像更加清晰。使所述试纸条盛放槽中容纳试纸条的区域的边框与试纸条的形状匹配，是为了避免试纸条盛放槽中容纳试纸条的区域的边框与试纸条的边缘之间的间隙会在采集到的图像中形成阴影，进而影响个性化标志区信息的正确读取。
S403：将多个样品容纳腔的滴液管路对应放置在每个试纸条液体吸取区的上方，以使试纸条对样品容纳腔内的液体样品进行层析检测；
在一种可能的实现方式中，多个样品容纳腔中的样品液体积相同；试纸条与液体样品接触时间相同；滴液管路放置在试纸条液体吸取区上方的位置相同。
在上述实现过程中，每个试纸条在检测时的检测条件基本相同，其目的是在保证几乎相同的检测条件下，每个试纸的检测结果稳定，避免由于不同的检测条件导致检测结果的不准确性。
S404：在试纸条层析完毕后利用移动终端对检测盘及其上的试纸条进行图像采集；
S405：将采集图像上传至数据处理中心进行数据处理，获得目标物的检测结果；
S406：向移动终端返回目标物的检测结果。
根据本发明的又一方面，还提供了一种利用移动终端对目标成分进行检测的系统。图7为根据一种实施例示出的利用移动终端对目标成分进行检测的系统的结构示意图，参见图7，利用移动终端对目标成分进行检测的系统包括：
样品液检测装置710，包括试纸条和检测盘；所述试纸条至少包括个性化标志区和结果显示区；所述检测盘用于限定试纸条绕同一圆心等角度排列，以得到试纸条排列环；所述检测盘上还设有用于定位所述试纸条排列环中试纸条位置的定位标识；
图像采集装置720，设置在所述移动终端上，被配置用于对试纸条排列环进行图像采集；
数据处理装置730，被配置用于对采集到的图像进行数据处理，并获得目标成分的测试结果；
测试结果接收装置740，被配置用于接收目标成分的测试结果，所述测试结果接收装置设置在所述移动终端上。
本实施例中的利用移动终端对目标成分进行检测的系统用于进行上述的利用移动终端对目标成分进行检测的方法；或者所述系统用于进行对多目标物同步进行检测的方法。
可选地，图像采集装置720和测试结果接收装置740可以都设置在移动终端上。
在一种可能的实现方式中，所述数据处理装置可以包括：
图像矫正单元731，被配置用于识别采集图像中的定位标识并根据定位标识对采集图像进行矫正；
图像分割单元732，被配置用于分割每个试纸条中个性化标志区和结果显示区的图像；
计算单元733，被配置用于计算结果显示区的显色结果，并将所述显色结果与预先建立的与该个性 化标志区中的身份信息匹配的标准数据库中的标准显色结果比对，获取目标成分的测试结果。
在上述实现过程中，图像矫正单元的矫治方法参见利用移动终端对目标成分进行检测的方法中对于图形的矫治方法，此处不再赘述。
在一种可能的实现方式中，所述数据处理装置设置可以设置在所述移动终端上。在另一种可能的实现方式中，数据处理装置可以设置在与移动终端通信连接的远程终端上。
效果验证：
(1)选取农药戊唑醇的样品液，将不同浓度的戊唑醇样品液置于相同容积的样品容纳腔中，采用相同的检测条件使试纸条进行层析，待层析完毕后得到显色试纸条；
(2)将步骤(1)显色后的试纸条按照操作规范要求排放在检测盘的试纸条盛放槽中，并用移动终端(手机)进行拍照，拍照后上传至数据处理中心，获得T/C值-手机。
(3)将步骤(1)显色后的试纸条置于手持式食品安全分析仪GT-710中，获得T/C值-仪器。
测试结果如表1：
Figure PCTCN2020127664-appb-000001
将T/C值-手机和T/C值-仪器进行线性拟合，得到其R 2＝0.9969，即两者的趋势变化高度相关。
从上述测试结果可以看出，用移动终端(手机)对使用本公开的目标物筛查的检测装置进行拍摄，获取的T/C值，较仪器获取的T/C值高。但是从两者线性拟合结果可以看出，两者的变化趋势高度一致，即选择各自独立的标准曲线时，对目标物的测试结果判别是一致的。
以上仅为本公开的优选实施例而已，并不用于限制本公开，对于本领域的技术人员来说，本公开可以有各种更改和变化。凡在本公开的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本公开的保护范围之内。
工业实用性
本公开实施例提供的利用移动终端对目标成分进行检测的方法，利用圆周阵列的试纸条排布方式，通过在图像识别过程中识别定位标识，分割出需要的试纸条区域，获得色度值，从而与对应的标准数据库的色度值比较，获得测试结果，这种方式省略了直接进行显色区识别的过程，降低了由于边缘识别不准确，导致的试纸条宽度方向识别误差较大的劣势；同时，这种处理过程能够实现多通道检测，且对于每一个通道的试纸条的检测都能够输出可靠的检测结果；此外，这种方式不受移动终端种类、拍摄角度倾斜等因素的影响，具有对操作人员专业度要求不高，能够随时随地在常规环境光条件下进行目标物定性和/或定量检测的特点。
本公开实施例提供的对多目标物同步进行检测的方法，仅需要进行试纸条的层析检测、试纸条摆放、移动终端拍照，上传系统，既可以获得测试结果，过程简单，操作难度低，易于推广，为样品液的目标成分检测实现准确测量；同时能够利用移动终端实现多通道试纸条的检测。
本公开实施例提供的利用移动终端对目标成分进行检测的系统，仅使用样品液检测装置和搭载有图像采集装置、测试结果接收装置的移动终端和数据处理装置(可在云端或移动终端)即可以实现的目标成分的检测，装置简单、体积小、易携带，操作简单，可实现家庭使用，易于市场化推广，测试结果可靠。

Claims (22)

  1. 一种利用移动终端对目标成分进行检测的方法，其特征在于，包括：
    使用试纸条对待测样品液进行检测，得到显色的试纸条；所述试纸条至少包括个性化标志区和结果显示区；
    将试纸条绕同一圆心等角度排列，得到试纸条排列环；在所述试纸条排列环上、所述试纸条之外的检测盘区域设置有定位标识；
    使用移动终端对试纸条排列环进行图像采集，并将采集图像上传至数据处理中心；
    识别所述采集图像中的定位标识，并根据定位标识对采集图像进行矫正，根据所述定位标识与所述试纸条之间预先设定的位置关系确定矫正图像中每个试纸条的个性化标志区和结果显示区的位置，根据确定的每个试纸条的个性化标志区和结果显示区的位置进行图像分割，分割出每个试纸条中个性化标志区和结果显示区的图像；
    计算结果显示区的显色结果，并将所述显色结果与预先建立的与该个性化标志区中的身份信息匹配的标准数据库中的标准显色结果比对，获取目标成分的测试结果；
    输出目标成分的测试结果并在所述移动终端上显示。
  2. 根据权利要求1所述的方法，其特征在于，所述根据定位标识对采集图像进行矫正包括：
    拍摄角度的矫正和位置偏离的矫正；
    优选地，所述根据定位标识对采集图像进行矫正包括：识别定位标识的位置和/或形状，根据所述定位标识的位置和/或形状对采集图像的拍摄角度进行矫正和/或对采集图像的位置偏离进行矫正。
  3. 根据权利要求1或2所述的方法，其特征在于，所述定位标识具有预定的形状，设置在预定的位置；
    优选地，所述定位标识的形状为具有明显的顶点和直边的形状。
  4. 根据权利要求1至3中任一项所述的方法，其特征在于，所述试纸条排列环通过将所述试纸条限位在检测盘上获得；所述定位标识为设置在所述检测盘上的标记块，和/或所述定位标识为所述检测盘的边缘；
    优选地，所述标记块为设置在所述检测盘上的区别标记块和对比标记块。
  5. 根据权利要求1至4中任一项所述的方法，其特征在于，所述分割出每个试纸条中个性化标志区和结果显示区的图像包括：
    识别所述采集图像中的标记块，并根据标记块对采集图像进行矫正，根据所述标记块与所述试纸条之间预先设定的位置关系确定矫正图像中每个试纸条的个性化标志区和结果显示区的位置，根据确定的每个试纸条的个性化标志区和结果显示区的位置进行图像分割，得到每个试纸条中个性化标志区和结果显示区的分割图像；
    可选地，所述分割出每个试纸条中个性化标志区和结果显示区的图像包括：
    识别所述采集图像中的检测盘边缘，并根据检测盘边缘对采集图像进行矫正，根据所述检测盘边缘与所述试纸条之间预先设定的位置关系确定矫正图像中每个试纸条的个性化标志区和结果显示区的位置，根据确定的每个试纸条的个性化标志区和结果显示区的位置进行图像分割，得到每个试纸条中个性化标志区和结果显示区的分割图像；
    可选地，所述分割出每个试纸条中个性化标志区和结果显示区的图像包括：
    识别所述采集图像中的标记块和检测盘边缘，并根据标记块和检测盘边缘对采集图像进行矫正，根据所述标记块和检测盘边缘的共同信息，以及其与所述试纸条之间预先设定的位置关系确定矫正图像中每个试纸条的个性化标志区和结果显示区的位置，根据确定的每个试纸条的个性化标志区和结果显示区的位置进行图像分割，得到每个试纸条中个性化标志区和结果显示区的分割图像。
  6. 根据权利要求1至5中任一项所述的方法，其特征在于，所述试纸条中结果显示区包括T线和C线；
    所述显色结果为T线图像色度值与C线图像色度值的比值；或所述显色结果为T线图像的色度值，所述色度值包括RGB值、灰度值或光度值。
  7. 根据权利要求6所述的方法，其特征在于，计算所述显色结果为T线图像色度值与C线图像色度值的比值时，包括：
    使T线图像相对于背景色的色度值与C线图像相对于背景色的色度值的比值作为所述显色结果；
    优选地，所述背景色的选取区域位于所述结果显示区中的T线附近或者C线附近；
    优选地，所述背景色的选取区域位于T线和C线之间。
  8. 根据权利要求1至7中任一项所述的方法，其特征在于，在所述使用试纸条对目标成分进行检测时，包括：
    将试纸条分别放置于盛放有目标成分的多个样品容纳腔中，多个样品容纳腔中的样品液体积相同；试纸条放入所述样品容纳腔中的倾斜角度相同，放入时间相同。
  9. 根据权利要求4至8中任一项所述的方法，其特征在于，还包括：通过所述标记块对所述试纸条排列环中试纸条的次序进行标定；
    优选地，以能够与其余标记块进行区别的一个标记块为次序起点，按顺时针方向或逆时针方向依次为所述试纸条排列环中的试纸条进行排序。
  10. 根据权利要求1至9中任一项所述的方法，其特征在于，所述移动终端的图像采集设备的像素至少为800万。
  11. 一种对多目标物同步进行检测的方法，其特征在于，包括：
    将待测液体样品液盛装在多个样品容纳腔内；
    使用试纸条对样品容纳腔内的样品进行层析检测；所述试纸条至少包括个性化标志区和结果显示区；
    将层析检测后的试纸条放置在设置有定位标识的检测盘上，所述检测盘能够使所述试纸条在同一圆环区域内绕所述检测盘的中心等角度排列；
    利用移动终端对所述检测盘进行图像采集；
    将采集图像上传至数据处理中心进行数据处理，识别所述采集图像中的定位标识，并根据定位标识对采集图像进行矫正，根据所述定位标识与所述试纸条之间预先设定的位置关系确定矫正图像中每个试纸条的个性化标志区和结果显示区的位置，根据确定的每个试纸条的个性化标志区和结果显示区的位置进行图像分割，得到每个试纸条中个性化标志区和结果显示区的分割图像，获得目标物的检测结果；
    向移动终端返回目标物的检测结果。
  12. 一种对多目标物同步进行检测的方法，其特征在于，包括：
    将待测液体样品液盛装在多个底部开有滴液管路的样品容纳腔内；
    将试纸条放置在设置有定位标识的检测盘上，所述试纸条在所述检测盘的一个圆环区域内绕检测盘的中心等角度排列；所述试纸条至少包括个性化标志区、结果显示区、液体吸取区；
    将多个样品容纳腔的滴液管路对应放置在每个试纸条液体吸取区的上方，以使试纸条对样品容纳腔内的液体样品进行层析检测；
    在试纸条层析完毕后利用移动终端对检测盘及其上的试纸条进行图像采集；
    将采集图像上传至数据处理中心进行数据处理，识别所述采集图像中的定位标识，并根据定位标识对采集图像进行矫正，根据所述定位标识与所述试纸条之间预先设定的位置关系确定矫正图像中每个试纸条的个性化标志区和结果显示区的位置，根据确定的每个试纸条的个性化标志区和结果显示区的位置进行图像分割，得到每个试纸条中个性化标志区和结果显示区的分割图像，获得目标物的检测结果；
    向移动终端返回目标物的检测结果。
  13. 根据权利要求11或12所述的方法，其特征在于，所述检测盘上表面设置的定位标识为标记块，用于在图像采集处理过程中，对试纸条进行定位标记；
    优选地，所述标记块包括区别标记块和对比标记块；所述区别标记块用于与所述对比标记块进行区别；
    优选地，所述区别标记块与所述对比标记块的总个数不少于三个；
    优选地，所述标记块的形状至少包括顶点和直边；
    优选地，所述标记块为一个蓝色正方形色块和三个绿色正方形色块，或者所述标记块为一个绿色正方形色块和三个蓝色正方形色块。
  14. 根据权利要求11至13中任一项所述的方法，其特征在于，所述检测盘上表面为正多边形；
    优选地，所述检测盘的上表面为中性色表面；
    优选地，所述检测盘的上表面为漫反射表面。
  15. 根据权利要求11至14中任一项所述的方法，其特征在于，在试纸条对样品容纳腔内的样品进行层析检测时，所述多个样品容纳腔中的样品液量相同；所述试纸条与所述样品容纳腔中的液体样品接触时间相同；
    可选地，在所述试纸条插入所述样品容纳腔内时，所述试纸条插入所述样品容纳腔的倾斜角度相同；
    可选地，在所述试纸条位于所述样品容纳腔底部时，滴液管路放置在试纸条液体吸取区上方的位置相同。
  16. 根据权利要求1至15中任一项所述的方法，其特征在于，在将所述试纸条放置到所述检测盘上后，所述试纸条的上表面与所述检测盘的上表面齐平；
    优选地，所述结果显示区的上表面与所述检测盘的上表面齐平。
  17. 根据权利要求11至16中任一项所述的方法，所述移动终端的图像采集设备的像素至少为800万。
  18. 根据权利要求11至17中任一项所述的方法，其特征在于，在所述检测盘上设置自所述检测盘上表面向下凹陷的试纸条盛放槽，用于盛放所述试纸条；
    优选地，在所述试纸条盛放槽的底部设置用以将所述试纸条的下表面与所述试纸条盛放槽的底部分离的隔离块；
    优选地，在将所述试纸条放入所述试纸条盛放槽时，使所述个性化标志区靠近所述检测盘的圆心，并使所述试纸条盛放槽中容纳试纸条的区域的边框与试纸条的形状匹配。
  19. 一种利用移动终端对目标成分进行检测的系统，其特征在于，包括：
    样品液检测装置，包括试纸条和检测盘；所述试纸条至少包括个性化标志区和结果显示区；所述检测盘用于限定试纸条绕同一圆心等角度排列，以得到试纸条排列环；所述检测盘上还设有用于图像采集后用于定位所述试纸条排列环中试纸条位置的定位标识；
    图像采集装置，设置在所述移动终端上，被配置用于对试纸条排列环进行图像采集；
    数据处理装置，被配置用于对采集到的图像进行数据处理，识别采集到的图像中的定位标识，并根据定位标识对采集图像进行矫正，根据所述定位标识与所述试纸条之间预先设定的位置关系确定矫正图像中每个试纸条的个性化标志区和结果显示区的位置，根据确定的每个试纸条的个性化标志区和结果显示区的位置进行图像分割，得到每个试纸条中个性化标志区和结果显示区的分割图像，获得目标成分的测试结果；
    测试结果接收装置，被配置用于接收目标成分的测试结果，所述测试结果接收装置设置在所述移动终端上。
  20. 根据权利要求19所述的系统，其特征在于，所述系统用于进行权利要求1-10中任一项所述的快检方法；或者所述系统用于进行权利要求11-18中任一项所述的快检方法。
  21. 根据权利要求19所述的系统，其特征在于，所述数据处理装置包括：
    图像矫正单元，被配置用于识别采集图像中的定位标识并根据定位标识对采集图像进行矫正；
    图像分割单元，被配置用于分割每个试纸条中个性化标志区和结果显示区的图像；
    计算单元，被配置用于计算结果显示区的显色结果，并将所述显色结果与预先建立的与该个性化标志区中的身份信息匹配的标准数据库中的标准显色结果比对，获取目标成分的测试结果。
  22. 根据权利要求19至21中任一项所述的系统，其特征在于，所述数据处理装置设置在所述移动终端上；或者所述数据处理装置设置在与所述移动终端通信连接的远程终端上。
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