WO2020261771A1 - Composition d'acide peracétique pour le nettoyage de dispositifs médicaux et son procédé de production - Google Patents

Composition d'acide peracétique pour le nettoyage de dispositifs médicaux et son procédé de production Download PDF

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Publication number
WO2020261771A1
WO2020261771A1 PCT/JP2020/018593 JP2020018593W WO2020261771A1 WO 2020261771 A1 WO2020261771 A1 WO 2020261771A1 JP 2020018593 W JP2020018593 W JP 2020018593W WO 2020261771 A1 WO2020261771 A1 WO 2020261771A1
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WO
WIPO (PCT)
Prior art keywords
mass
acid
cleaning
salt
sterilizing
Prior art date
Application number
PCT/JP2020/018593
Other languages
English (en)
Japanese (ja)
Inventor
和志 杉本
君塚　健一
守悟 佐藤
Original Assignee
三菱瓦斯化学株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 三菱瓦斯化学株式会社 filed Critical 三菱瓦斯化学株式会社
Priority to JP2021527438A priority Critical patent/JPWO2020261771A1/ja
Publication of WO2020261771A1 publication Critical patent/WO2020261771A1/fr
Priority to JP2024114802A priority patent/JP2024133297A/ja

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/26—Organic compounds containing oxygen
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/32—Organic compounds containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/36—Organic compounds containing phosphorus

Definitions

  • the sterilizing and cleaning composition may contain a phosphorus-based stabilizer as an additive.
  • the carboxylic acid-based stabilizer may be ethylenediaminetetraacetic acid (EDTA) or a salt thereof.
  • the carboxylic acid stabilizer may be diethylenetriamine pentaacetic acid (DTPA) or a salt thereof.
  • the carboxylic acid-based stabilizer may be ethylenediaminetetraacetic acid (EDTA) or a salt thereof.
  • the sterilizing and cleaning composition contains 0.0001 to 0.30% by mass of the phosphorus-based stabilizer and 0.0001 to 0.30% by mass of the above-mentioned and the carboxylic acid-based stabilizer. % May be included.
  • TPO Total Peroxide Concentration
  • the total peroxide concentration of the sterilization and cleaning composition was determined by the iodine reduction titration method. Specifically, about 0.1 g of the sample is precisely weighed, placed in a 250 mL Erlenmeyer flask, 100 mL of pure water is added, 10 mL of 1.8 mol / L sulfuric acid is added, and then 10 mL of a 10 mass% potassium iodide solution, 1 mass%. A few drops of ammonium molybdate solution were added to prepare a test solution.
  • ⁇ pH measurement> The pH of the cleaning composition and the diluted solution of the cleaning composition was measured using a pH meter (LAQUA, D-71S, manufactured by HORIBA, Ltd.).
  • Bacillus cereus standard strain (manufactured by Microbiologicals, product name: Bacillus cereus ATCC10876) was applied to MYP agar (manufactured by AZONE Co., Ltd., product name: Sanispec raw medium) and cultured at 35 ° C. for 7 days. Distilled sterilized water was added to this agar medium, and the cells were scraped off with a spreader and collected, and washed with sterilized distilled water by centrifugation. In order to obtain only the spore type, the bacteria that survived by heating at 80 ° C. for 10 minutes were used as a spore suspension.
  • the cleaning composition was appropriately diluted with sterilized distilled water to prepare a sample solution.
  • 0.5 mL of 1 mass% albumin solution and 50 ⁇ L of spore suspension were added to 4.5 mL of each sample solution, and the mixture was allowed to act at 25 ° C. for 120 minutes.
  • dilute 10-fold with 0.1 mol / L sterilized sodium thiosulfate solution and use a medium for detecting Bacillus cereus (manufactured by Nissui Pharmaceutical Co., Ltd., product name: Compact Dry X-BC) at 35 ° C. 48.
  • the cells were cultured for hours and the viable cell count was measured. In addition, the viable cell count of the spore suspension was measured and used as the viable cell count at the start.
  • the cleaning composition was appropriately diluted with pure water to prepare 50 g of a sample solution.
  • a washing evaluation indicator (Nescos IC WI, manufactured by Sakura Color Products Corporation) was immersed in each sample solution for 60 minutes, washed with 10 mL of pure water, and dried at room temperature.
  • the color difference ( ⁇ Eab) from the clean white part of the cleaning evaluation indicator was measured using a handy type spectrocolor difference meter (NF555, manufactured by Nippon Denshoku Industries Co., Ltd.) set to a C light source and a 2 degree field of view.
  • the protein removal rate was calculated from the ratio of the color difference after washing, with the color difference of the unwashed washing evaluation indicator as 100.
  • ⁇ Calcium carbonate dissolution amount test> The cleaning composition was appropriately diluted with pure water to prepare 50 g of a sample solution. Ca carbonate (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) was added little by little to each sample solution, and the dissolved weight was defined as the amount of Ca carbonate dissolved.
  • Example 1 22.0 g of pure water and 60% by mass of 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP, manufactured by Italmatch Japan Co., Ltd., product name: Dayquest 2010) 0.17 g, ethylenediaminetetraacetic acid disodium di.
  • HEDP 1-hydroxyethylidene-1,1-diphosphonic acid
  • Examples 15 to 20> The sterilizing and cleaning compositions having the concentrations shown in Table 2 were obtained in the same manner as in Example 1 except that the formulations were as shown in Table 2 and aged at 50 ° C. for 1 day. The sterilization and cleaning compositions were aged at 50 ° C. for 1 day after preparation, and the total peroxide concentration (TPO) was measured after 20 days at 25 ° C. to calculate the stability. The results are shown in Table 2.
  • Examples 21 to 22, Comparative Examples 7 to 12> A sterilizing and cleaning composition having the concentration shown in Table 3 was obtained in the same manner as in Example 1 except that the formulation was as shown in Table 3 and the mixture was aged at 25 ° C. for 21 days.
  • TPO total peroxide concentration
  • the results are shown in Table 3. The following were used as 50% phytic acid and NaOH shown in the table. 50% by mass phytic acid solution (50% phytic acid, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) Sodium hydroxide (NaOH, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.)
  • Example 102 Comparative Example 101>
  • the sterilizing and cleaning compositions having the concentrations shown in Table 7 were obtained in the same manner as in Example 101 except that the formulations were as described in Table 7. With respect to the obtained cleaning composition, the total peroxide concentration was measured 14 days after the preparation, and the stability was calculated. A pH measurement, a sterilization test, a protein removal test, and a calcium carbonate dissolution amount test were carried out, and the number of bacteria, the protein removal rate, and the calcium carbonate dissolution amount after 120 minutes were calculated. The results are shown in Tables 7 and 8.
  • the stability shown in Table 7 was evaluated in the same manner as in Example 101.
  • the following pyrophosphoric acids were used as the pyrophosphoric acids shown in the table. Pyrophosphoric acid (manufactured by Junsei Chemical Co., Ltd., product name: diphosphoric acid)
  • the composition for sterilization and cleaning of medical devices in which the stability of the peroxide is high, the wastewater meets the sewage exclusion standard, and the protein removing ability is improved by adding the additive. It has been shown that goods can be provided.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Toxicology (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Le problème décrit par la présente invention est de fournir une composition de stérilisation et de nettoyage de dispositif médical qui présente une stabilité élevée au peroxyde, répond aux normes d'élimination des eaux usées lorsqu'elle est déversée, et présente une capacité d'élimination des protéines améliorée. La solution selon l'invention porte sur une composition de stérilisation et de nettoyage qui contient 0,001 à 15 % en masse d'acide peracétique, 0,01 à 70 % en masse d'acide acétique et/ou un sel de celui-ci, 0,001 à 25 % en masse de peroxyde d'hydrogène, et de l'eau; et contient un additif, la valeur de pH de la composition étant de 4,0 à 10,0.
PCT/JP2020/018593 2019-06-26 2020-05-08 Composition d'acide peracétique pour le nettoyage de dispositifs médicaux et son procédé de production WO2020261771A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021527438A JPWO2020261771A1 (fr) 2019-06-26 2020-05-08
JP2024114802A JP2024133297A (ja) 2019-06-26 2024-07-18 医療機器洗浄用過酢酸組成物及びその製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019118563 2019-06-26
JP2019-118563 2019-06-26

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WO2020261771A1 true WO2020261771A1 (fr) 2020-12-30

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JP (2) JPWO2020261771A1 (fr)
TW (1) TW202114519A (fr)
WO (1) WO2020261771A1 (fr)

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63286158A (ja) * 1987-05-19 1988-11-22 Menikon:Kk コンタクトレンズの消毒方法
JPH08311495A (ja) * 1995-05-22 1996-11-26 Ecolab Inc 製品の消毒および漂白方法およびそれらに用いられる組成物
WO2000022931A1 (fr) * 1998-10-19 2000-04-27 Saraya Co., Ltd. Composition bactericide/desinfectante a base d'acide peracetique
JP2006193631A (ja) * 2005-01-14 2006-07-27 Yokohama Yushi Kogyo Kk 過酢酸および非イオン界面活性剤を含む消毒洗浄組成物
JP2008138027A (ja) * 2006-11-30 2008-06-19 Kao Corp 液体殺菌洗浄剤組成物
JP2010095448A (ja) * 2008-10-14 2010-04-30 Fujifilm Corp 医療器具用消毒液及び医療器具消毒方法
JP2010184868A (ja) * 2009-02-10 2010-08-26 Mitsubishi Gas Chemical Co Inc 安定性に優れる過酢酸水溶液
JP2011219610A (ja) * 2010-04-08 2011-11-04 Lion Corp 医療器具用洗浄剤組成物
JP2016505564A (ja) * 2012-12-14 2016-02-25 サバン ベンチャーズ ピーティーワイ リミテッド 相乗的消毒作用増強
WO2020100837A1 (fr) * 2018-11-12 2020-05-22 三菱瓦斯化学株式会社 Composition de stérilisation et de nettoyage, procédé pour sa production et procédé de stérilisation et de nettoyage l'utilisant

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63286158A (ja) * 1987-05-19 1988-11-22 Menikon:Kk コンタクトレンズの消毒方法
JPH08311495A (ja) * 1995-05-22 1996-11-26 Ecolab Inc 製品の消毒および漂白方法およびそれらに用いられる組成物
WO2000022931A1 (fr) * 1998-10-19 2000-04-27 Saraya Co., Ltd. Composition bactericide/desinfectante a base d'acide peracetique
JP2006193631A (ja) * 2005-01-14 2006-07-27 Yokohama Yushi Kogyo Kk 過酢酸および非イオン界面活性剤を含む消毒洗浄組成物
JP2008138027A (ja) * 2006-11-30 2008-06-19 Kao Corp 液体殺菌洗浄剤組成物
JP2010095448A (ja) * 2008-10-14 2010-04-30 Fujifilm Corp 医療器具用消毒液及び医療器具消毒方法
JP2010184868A (ja) * 2009-02-10 2010-08-26 Mitsubishi Gas Chemical Co Inc 安定性に優れる過酢酸水溶液
JP2011219610A (ja) * 2010-04-08 2011-11-04 Lion Corp 医療器具用洗浄剤組成物
JP2016505564A (ja) * 2012-12-14 2016-02-25 サバン ベンチャーズ ピーティーワイ リミテッド 相乗的消毒作用増強
WO2020100837A1 (fr) * 2018-11-12 2020-05-22 三菱瓦斯化学株式会社 Composition de stérilisation et de nettoyage, procédé pour sa production et procédé de stérilisation et de nettoyage l'utilisant

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Publication number Publication date
JP2024133297A (ja) 2024-10-01
TW202114519A (zh) 2021-04-16
JPWO2020261771A1 (fr) 2020-12-30

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