WO2020259053A1 - Cathéter de thrombolyse et ensemble cathéter de thrombolyse - Google Patents
Cathéter de thrombolyse et ensemble cathéter de thrombolyse Download PDFInfo
- Publication number
- WO2020259053A1 WO2020259053A1 PCT/CN2020/086906 CN2020086906W WO2020259053A1 WO 2020259053 A1 WO2020259053 A1 WO 2020259053A1 CN 2020086906 W CN2020086906 W CN 2020086906W WO 2020259053 A1 WO2020259053 A1 WO 2020259053A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- thrombolytic
- tube
- section
- guide wire
- universal guide
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M25/005—Catheters; Hollow probes characterised by structural features with embedded materials for reinforcement, e.g. wires, coils, braids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
- A61M2025/091—Guide wires having a lumen for drug delivery or suction
Definitions
- Invention name A thrombolytic tube and thrombolytic tube assembly
- the invention relates to the technical field of medical devices, and more specifically, to a thrombolytic tube and a thrombolytic tube assembly.
- thrombolytic drug therapy which gradually dissolves the thrombus by injecting thrombolytic drugs to achieve the purpose of opening blood vessels.
- thrombolytic drug therapy usually requires a thrombolytic tube assembly, which usually involves a thrombolytic tube and a guide wire.
- the universal guide wire cannot be used normally, and a non-universal guide wire with a thinner body needs to be specially designed.
- the tip of the tube must be thickened to the universal guide wire size of 0.035” to seal the tip of the thrombolytic tube, and the drug can flow out through the drug delivery hole of the thrombolytic tube to fully contact the thrombus.
- the overall diameter of the non-universal guide wire is thinner.
- the processing equipment and technology of the non-universal guide wire are more difficult, which directly increases
- the production cost of the thrombolytic tube assembly further increases the cost of clinical thrombosis treatment.
- the technical problem to be solved by the present invention is how to reduce the treatment cost of clinical thrombosis.
- the present invention provides a thrombolytic tube and a thrombolytic tube assembly.
- a thrombolytic tube includes a closed section, a working section, and a fixed section arranged in sequence from the head end to the tail end, wherein the working section is provided with a liquid injection port and a drug delivery hole, and the fixed section is detachably provided with a fixed section.
- a knob when the universal guide wire is inserted into the thrombolytic tube, the universal guide wire can close the inlet of the fixed knob and the outlet of the closed section, and the inner wall of the working section and the universal guide wire There is a dosing gap between.
- it further includes a first contraction section whose outer diameter gradually decreases from the working section to the closed section.
- it further includes a second contraction section whose outer diameter gradually decreases from the fixed section to the working section.
- the inner diameters of the working section and the fixed section are the same.
- the outer surface of the thrombolytic tube is provided with an antibacterial coating.
- the antibacterial coating is a silver-plated layer.
- the outer surface of the thrombolytic tube is provided with an anticoagulant layer.
- the anticoagulant layer is a heparin layer.
- the present invention also discloses another thrombolytic tube, which includes a closed section, a working section and a fixed section arranged in sequence from the head end to the tail end, wherein the working section is provided with a liquid injection port for injecting liquid into the thrombolytic tube and A drug delivery hole for drug delivery to the lesion, the fixed section is detachably provided with a fixed knob, when the universal guide wire is inserted into the thrombolytic tube, the universal guide wire can close the entrance and the fixed section There is a drug delivery gap between the outlet of the closed section and the inner wall of the working section and the universal guide wire.
- the present invention also discloses a thrombolytic tube assembly, including the thrombolytic tube as described in any one of the above and a general guide wire that can be inserted into the thrombolytic tube.
- it further includes a spiral guide wire or a curved guide wire that can be inserted into the thrombolytic tube.
- the universal guide wire when the universal guide wire is inserted into the thrombolytic tube, the universal guide wire can close the inlet of the fixed knob and the outlet of the closed section, And there is a drug delivery gap between the inner wall of the working section and the universal guide wire. That is to say, the thrombolytic tube of the present invention can use a universal guide wire, without the need to use a high-cost non-universal guide wire, which can achieve the purpose of smooth administration, and reduce the thrombolytic tube assembly in the treatment of clinical thrombosis. Therefore, the cost of clinical thrombosis treatment is reduced.
- Figure 1 is a schematic top view of a thrombolytic tube provided by an embodiment of the present invention.
- Fig. 2 is a partial structural diagram of a thrombolytic tube provided by an embodiment of the present invention
- FIG. 3 is a schematic top view of another thrombolytic tube provided by an embodiment of the present invention.
- FIG. 4 is a schematic top view of another thrombolytic tube provided by an embodiment of the present invention.
- FIG. 5 is a schematic top view of another thrombolytic tube provided by an embodiment of the present invention.
- FIG. 6 is a schematic top view of another thrombolytic tube provided by an embodiment of the present invention.
- FIG. 7 is a schematic top view of another thrombolytic tube provided by an embodiment of the present invention.
- Figure 8 is a schematic top view of another thrombolytic tube provided by an embodiment of the present invention.
- FIG. 9 is a schematic top view of another thrombolytic tube provided by an embodiment of the present invention.
- FIG. 10 is a schematic diagram of a three-dimensional structure of a universal guide wire provided by an embodiment of the present invention.
- FIG. 11 is a schematic diagram of a three-dimensional structure of another universal guide wire provided by an embodiment of the present invention.
- 100 is the thrombolytic tube
- 101 is the closed section
- 102 is the working section
- 103 is the fixed section
- 104 is the liquid injection port
- 105 is the dosing hole
- 106 positions the fixed knob
- 107 positions the first contraction section
- 200 is a guide wire
- 300 is a blood vessel
- 400 is a thrombus.
- the diameter of the thrombolysis tube is 5F (3F is about 1mm), and the non-universal guide wire is compatible with it.
- the diameter is 0.035", and the body part is thinner to ensure that when the non-universal guide wire is inserted into the thrombolytic tube, there is a gap between the non-universal guide wire and the thrombolytic tube.
- the manufacturing cost of non-universal guide wires is much higher than that of general guide wires. Since the size of the non-universal guide wire is not common with the size of the non-universal guide wire, the non-universal guide wire is not suitable for repeated use, resulting in waste of equipment.
- the core of the present invention is to provide a thrombolytic tube and a thrombolytic tube assembly to reduce the cost of clinical thrombosis treatment.
- the thrombolysis tube 100 in the embodiment of the present invention includes a closed section 101, a working section 102, and a fixed section 103 arranged in sequence from the head end to the tail end, wherein the working section 102 is provided with The injection port 104 of the plug tube 100 for injecting liquid and the drug hole 105 for drug delivery to the lesion.
- the fixed section 103 is detachably provided with a fixed knob 106.
- the universal guide wire 200 when the universal guide wire 200 is inserted into the thrombolytic tube 100, the universal guide wire 200 can close the inlet of the fixed knob 106 and the outlet of the closed section 101, and the inner wall of the working section 102 is the same as the universal guide wire 200. There is a dosing gap between. That is to say, the thrombolytic tube 100 of the present invention can use the universal guide wire 200 without the need to use the non-universal guide wire with higher cost, so that the purpose of smooth administration can be achieved, and the clinical thrombolysis 400 can be reduced during the treatment. The cost of the thrombus assembly reduces the treatment cost of the clinical thrombus 400.
- the size of the thrombolytic tube 100 is 5F. Therefore, the drug solution has a relatively large pressure when passing through the administration hole 105, and the administration hole 105 is ejected to fully contact the thrombus 400.
- the universal guide wire 200 is used, which is equivalent to increasing the diameter of the working section 102 of the thrombolytic tube 100, when the liquid medicine passes through the dosing hole 105, the pressure is lower than that of the prior art, and it is slowly ejected.
- the effective contact area of the drug solution and the thrombus 400 is increased, and the enzymatic reaction is proportional to the contact area, thereby improving the therapeutic effect.
- the thrombolytic tube 100 can use the universal guide wire 200, and the universal guide wire 200 can be reused, the waste of the universal guide wire 200 can be reduced.
- the diameter of the working section 102 of the thrombolysis tube 100 in this case is increased compared to the diameter of the thrombolysis tube 100 in the prior art, and a size larger than 6F is generally adopted.
- the thrombolytic tube 100 in the present invention further includes a first contraction section 107 whose outer diameter gradually decreases from the working section 102 to the closed section 101. Therefore, the working section 102 and the closed section 101 can have a smoother transition, thereby reducing resistance when inserted into the blood vessel 300.
- the inner diameters of the working section 102 and the fixed section 103 are the same or different. Preferably, the same inner diameter is used to facilitate processing.
- the outer surface of the thrombolytic tube 100 is provided with an antibacterial coating.
- the provision of an antibacterial coating can reduce the probability of bacterial growth, thereby reducing the risk of infection and prolonging the residence time of the thrombolytic tube 100.
- the antibacterial coating is a coating made of antibacterial materials, for example, the antibacterial coating is a silver-plated layer.
- the thrombolytic tube 100 is in contact with blood in the blood vessel 300 for a long time. Therefore, the outer surface of the thrombolytic tube 100 is provided with an anticoagulant layer.
- an anticoagulant layer By providing an anticoagulant layer, the probability of blood clotting can be reduced.
- the anticoagulant layer is processed from anticoagulant materials, for example, the anticoagulant layer is a heparin layer.
- the thrombolytic tube 100 in the embodiment of the present invention includes a closed section 101, a working section 102, and a fixed section 103 arranged in sequence from the head end to the tail end, wherein the fixed section 103 is detachably provided with a fixed knob 106
- the working section 102 is provided with a liquid injection port 104 and a dosing hole 105; when the universal guide wire 200 is inserted into the thrombolytic tube 100 by the fixed knob 106 in turn, the universal guide wire 200 can close the inlet of the fixed knob 106 and the sealing section 101 There is a drug delivery gap between the inner wall of the working section 102 and the universal guide wire 200.
- the working section 102 and the fixed section 103 are an integral structure; and the inner diameter of the exit of the closed section 101 gradually becomes smaller until it can fit with the universal guide wire 200.
- the thrombolytic tube 100 in the embodiment of the present invention includes a closed section 101, a working section 102, and a fixed section 103 arranged in sequence from the head end to the tail end, wherein one end of the fixed section 103 is detachably provided with a fixed
- the knob 106, the other end of the fixed section 103 can be detachably arranged on the working section 102, and the side of the fixed section is provided with a liquid injection port 104 for injecting liquid into the thrombolytic tube 100, and the working section 102 is provided with a liquid injection port 104 for injecting liquid into the lesion
- the thrombolytic tube 100 in the embodiment of the present invention includes a closed section 101, a working section 102 and a fixed section 103 arranged in sequence from the head end to the tail end, wherein one end of the fixed section 103 is detachably provided with The fixed knob 106, the other end of the fixed section 103 can be detachably arranged on the working section 102, and the side of the fixed section is provided with a liquid injection port 104 for injecting liquid into the thrombolytic tube 100, and the working section 102 is provided with The drug delivery hole 105 for lesion administration; when the universal guide wire 200 is inserted into the thrombolytic tube 100, the universal guide wire 200 can seal the inlet of the fixed knob 106 and the outlet of the closed section 101, and the fixed section 103 is provided with a liquid injection port 104 There is a drug administration gap between the position of the inner wall of the working section 102 and the universal guide wire 200.
- the inner diameter of the exit of the closed section 101 gradually
- the thrombolytic tube 100 in the embodiment of the present invention includes a closed section 101, a working section 102, and a fixed section 103 arranged in sequence from the head end to the tail end, wherein one end of the fixed section 103 is detachably provided with a fixed Knob 106, the other end of the fixed section 103 is connected with the working section 102; the working section 102 is provided with a liquid injection port 104 for injecting liquid into the thrombolytic tube 100 and a drug delivery hole 105 for drug delivery to the lesion;
- the universal guide wire 200 can seal the inlet of the fixed section 103 and the outlet of the closed section 101, and there is a medication gap between the inner wall of the working section 102 and the universal guide wire 200.
- the working section 102 and the fixed section 103 are an integral structure; the inner diameter of the end of the fixed section 103 near the fixed knob 106 can be closed by the universal guide wire 200; the inner diameter of the exit of the closed section 101 is the same as the universal guide wire 200
- the first contraction section 107 is adapted to be adapted and the outer radial closed section 101 of the working section 102 gradually becomes smaller.
- the thrombolytic tube 100 in the embodiment of the present invention includes a closed section 101, a working section 102, and a fixed section 103 arranged in sequence from the head end to the tail end, wherein one end of the fixed section 103 is detachably provided with a fixed Knob 106, the other end of the fixed section 103 is connected with the working section 102; the working section 102 is provided with a liquid injection port 104 for injecting liquid into the thrombolytic tube 100 and a drug delivery hole 105 for drug delivery to the lesion;
- the universal guide wire 200 can seal the inlet of the fixed section 103 and the outlet of the closed section 101, and there is a medication gap between the inner wall of the working section 102 and the universal guide wire 200.
- the working section 102 and the fixed section 103 are an integral structure; the inner diameter of the end of the fixed section 103 close to the fixed knob 106 can be closed by the universal guide wire 200; and the inner diameter of the exit of the closed section 101 gradually decreases until It can be matched with the universal guide wire 200.
- the thrombolytic tube 100 in the embodiment of the present invention includes a closed section 101, a working section 102 and a fixed section 103 arranged in sequence from the head end to the tail end, wherein one end of the fixed section 103 is detachably provided with a fixed
- the knob 106, the other end of the fixed section 103 can be detachably arranged on the working section 102, and the side of the fixed section is provided with a liquid injection port 104 for injecting liquid into the thrombolytic tube 100, and the working section 102 is provided with a liquid injection port 104 for injecting liquid into the lesion
- the inner diameter of the end of the fixed section 103 close to the fixed knob 106 can be closed by the universal guide wire 200; the inner diameter of the exit of the closed section 101 is adapted to the universal guide wire 200, and the outer diameter of the working section 102 The closed section 101 gradually becomes smaller in the first contraction section 107.
- the thrombolytic tube 100 in the embodiment of the present invention includes a closed section 101, a working section 102, and a fixed section 103 arranged in sequence from the head end to the tail end, wherein one end of the fixed section 103 is detachably provided with a fixed
- the knob 106, the other end of the fixed section 103 can be detachably arranged on the working section 102, and the side of the fixed section is provided with a liquid injection port 104 for injecting liquid into the thrombolytic tube 100, and the working section 102 is provided with a liquid injection port 104 for injecting liquid into the lesion
- the present invention also discloses a thrombolytic tube assembly, which includes the thrombolytic tube 100 as described above and a universal guide wire 200 that can be inserted into the thrombolytic tube 100. Since the above-mentioned thrombolytic tube 100 has the above beneficial effects, the thrombolytic tube assembly including the thrombolytic tube 100 has corresponding effects, which will not be repeated here.
- the spiral guide wire also includes a spiral guide wire or a curved guide wire that can be inserted into the thrombolytic tube 100.
- the diameter of the spiral guide wire is the diameter of the universal guide wire 200.
- the spiral guide wire is spirally wound around the oy.
- the spiral guide wire 200 Because the spiral guide wire is inserted into the thrombolytic tube 100 under the premise of ensuring its hardness, the spiral guide wire 200 has a spiral structure, so it can drive the thrombolytic tube 100 to produce spiral deformation, thereby enabling Stirring the thrombus 400 at the blood vessel 300 produces a crushing effect, which further increases the contact area between the thrombolytic tube 100 and the thrombus 400, the liquid medicine and the thrombus 400, and accelerates the enzymatic reaction of the thrombus 400.
- the universal guide wire 200 is a curved guide wire, a part of the curved guide wire is bent in the first bend in the plane of zoy, and a part of the curved guide wire is bent in the second bend in the plane of xoy Part, the first curved part and the second curved part are alternately arranged.
- the first bending part and the second bending part can rotate on different planes so as to stir the thrombus 400 at the blood vessel 300 to produce a crushing effect, and further increase the thrombolytic tube 100 and thrombus 400, liquid medicine and The contact area of thrombus 400 accelerates the enzymatic reaction of thrombus 400.
- the above-mentioned universal guide wire 200 can also have other structures, as long as its diameter is the diameter of the universal guide wire, all within the protection scope of the present invention.
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- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
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Abstract
La présente invention concerne un cathéter de thrombolyse et un ensemble cathéter de thrombolyse. Selon la présente invention, lorsqu'un fil-guide universel est inséré dans le cathéter de thrombolyse, le fil-guide universel peut bloquer une entrée du bouton de fixation et une sortie du segment fermé, et un espace d'administration de médicament est formé entre la paroi interne du segment de travail et le fil-guide universel. C'est-à-dire que le cathéter de thrombolyse de la présente invention peut utiliser un fil-guide universel, sans avoir besoin d'utiliser un fil-guide non universel relativement coûteux, afin d'atteindre l'objectif d'une administration de médicament sans problème, ce qui réduit le coût d'un ensemble cathéter de thrombolyse pendant le traitement clinique de la thrombose, ce qui permet de réduire le coût du traitement clinique de la thrombose.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910561226.1A CN110180072A (zh) | 2019-06-26 | 2019-06-26 | 一种溶栓管以及溶栓管组件 |
CN201910561226.1 | 2019-06-26 |
Publications (1)
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WO2020259053A1 true WO2020259053A1 (fr) | 2020-12-30 |
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Family Applications (1)
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PCT/CN2020/086906 WO2020259053A1 (fr) | 2019-06-26 | 2020-04-26 | Cathéter de thrombolyse et ensemble cathéter de thrombolyse |
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CN (1) | CN110180072A (fr) |
WO (1) | WO2020259053A1 (fr) |
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CN110180072A (zh) * | 2019-06-26 | 2019-08-30 | 高峰 | 一种溶栓管以及溶栓管组件 |
Citations (4)
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US20030191460A1 (en) * | 2002-04-04 | 2003-10-09 | Angiodynamics, Inc. | Vascular treatment device and method |
CN103635222A (zh) * | 2011-04-05 | 2014-03-12 | 塞茂普特克斯公司 | 具有远侧尖端部分和近侧溶液腔管的微导管 |
CN104755126A (zh) * | 2012-08-30 | 2015-07-01 | C·巴盖伊珊 | 用于治疗血管疾病的装置和方法 |
CN110180072A (zh) * | 2019-06-26 | 2019-08-30 | 高峰 | 一种溶栓管以及溶栓管组件 |
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US5833706A (en) * | 1991-07-05 | 1998-11-10 | Scimed Life Systems, Inc. | Single operator exchange perfusion catheter having a distal catheter shaft section |
US5228452A (en) * | 1992-02-19 | 1993-07-20 | Target Therapeutics Inc. | Proximal end fitting with an improved seal for use in a catheter guidewire assembly |
US5417689A (en) * | 1994-01-18 | 1995-05-23 | Cordis Corporation | Thermal balloon catheter and method |
US5843050A (en) * | 1995-11-13 | 1998-12-01 | Micro Therapeutics, Inc. | Microcatheter |
CN2408878Y (zh) * | 2000-03-02 | 2000-12-06 | 霍新明 | 一种新型导尿管 |
AU2012205823A1 (en) * | 2011-01-10 | 2013-07-25 | Spotlight Technology Partners Llc | Apparatus and methods for accessing and treating a body cavity, lumen, or ostium |
CN102274575B (zh) * | 2011-05-17 | 2013-07-17 | 上海微创医疗器械(集团)有限公司 | 一种球囊扩张导管 |
CN105106021A (zh) * | 2015-09-22 | 2015-12-02 | 江苏苏云医疗器材有限公司 | 鼻胃肠管 |
CN107789719B (zh) * | 2017-11-13 | 2024-04-02 | 上海长海医院 | 无内芯式溶栓导管 |
CN109821139B (zh) * | 2017-11-23 | 2021-07-13 | 钟文 | 一种溶栓球囊导管装置 |
CN208959081U (zh) * | 2018-09-07 | 2019-06-11 | 昆明医科大学第一附属医院 | 一种鼻胃管 |
CN210583319U (zh) * | 2019-06-26 | 2020-05-22 | 高峰 | 一种溶栓管以及溶栓管组件 |
-
2019
- 2019-06-26 CN CN201910561226.1A patent/CN110180072A/zh active Pending
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2020
- 2020-04-26 WO PCT/CN2020/086906 patent/WO2020259053A1/fr active Application Filing
Patent Citations (4)
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US20030191460A1 (en) * | 2002-04-04 | 2003-10-09 | Angiodynamics, Inc. | Vascular treatment device and method |
CN103635222A (zh) * | 2011-04-05 | 2014-03-12 | 塞茂普特克斯公司 | 具有远侧尖端部分和近侧溶液腔管的微导管 |
CN104755126A (zh) * | 2012-08-30 | 2015-07-01 | C·巴盖伊珊 | 用于治疗血管疾病的装置和方法 |
CN110180072A (zh) * | 2019-06-26 | 2019-08-30 | 高峰 | 一种溶栓管以及溶栓管组件 |
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