WO2020259053A1

WO2020259053A1 - Thrombolysis catheter and thrombolysis catheter assembly

Info

Publication number: WO2020259053A1
Application number: PCT/CN2020/086906
Authority: WO
Inventors: 高峰
Original assignee: 高峰
Priority date: 2019-06-26
Filing date: 2020-04-26
Publication date: 2020-12-30
Also published as: CN110180072A

Abstract

The present invention discloses a thrombolysis catheter and a thrombolysis catheter assembly. When a universal guide wire is inserted into the thrombolysis catheter in the present invention, the universal guide wire can block an inlet of the fixing knob and an outlet of the closed segment, and a drug delivery gap is formed between the inner wall of the working segment and the universal guide wire. That is, the thrombolysis catheter of the present invention can use a universal guide wire, without needing to use a relatively expensive non-universal guide wire, to achieve the purpose of smooth drug delivery, which reduces the cost of a thrombolysis catheter assembly during the clinical treatment of thrombosis, thereby reducing the cost of clinical thrombosis treatment.

Description

Thrombolytic tube and thrombolytic tube assembly

This application claims the priority of the following Chinese patent applications, the entire contents of which are incorporated into this application by reference.

Application number: 201910561226.1

Application date: June 26, 2019

Invention name: A thrombolytic tube and thrombolytic tube assembly

Technical field

The invention relates to the technical field of medical devices, and more specifically, to a thrombolytic tube and a thrombolytic tube assembly.

Background technique

There are three commonly used clinical methods to treat thrombus. The first is the artificial mechanical method, which removes the thrombus in the blood vessel through surgery or a suction device. The second is to implant a stent to expand the lumen of the blood vessel. The third is thrombolytic drug therapy, which gradually dissolves the thrombus by injecting thrombolytic drugs to achieve the purpose of opening blood vessels. Among them, thrombolytic drug therapy usually requires a thrombolytic tube assembly, which usually involves a thrombolytic tube and a guide wire.

When the guide wire is indwelled in the thrombolytic tube, there must be a gap between the guide wire and the thrombolytic tube for smooth administration. Therefore, the universal guide wire cannot be used normally, and a non-universal guide wire with a thinner body needs to be specially designed. The tip of the tube must be thickened to the universal guide wire size of 0.035” to seal the tip of the thrombolytic tube, and the drug can flow out through the drug delivery hole of the thrombolytic tube to fully contact the thrombus. Compared with the general guide wire, the overall diameter of the non-universal guide wire is thinner. Compared with the mature equipment and technology for processing the general guide wire, the processing equipment and technology of the non-universal guide wire are more difficult, which directly increases The production cost of the thrombolytic tube assembly further increases the cost of clinical thrombosis treatment.

Therefore, how to reduce the cost of treatment of clinical thrombosis is an urgent problem to be solved by those skilled in the art.

Summary of the invention

In view of this, the technical problem to be solved by the present invention is how to reduce the treatment cost of clinical thrombosis. To this end, the present invention provides a thrombolytic tube and a thrombolytic tube assembly.

In order to achieve the above objectives, the present invention provides the following technical solutions:

A thrombolytic tube includes a closed section, a working section, and a fixed section arranged in sequence from the head end to the tail end, wherein the working section is provided with a liquid injection port and a drug delivery hole, and the fixed section is detachably provided with a fixed section. A knob, when the universal guide wire is inserted into the thrombolytic tube, the universal guide wire can close the inlet of the fixed knob and the outlet of the closed section, and the inner wall of the working section and the universal guide wire There is a dosing gap between.

In one of the embodiments of the present invention, it further includes a first contraction section whose outer diameter gradually decreases from the working section to the closed section.

In one of the embodiments of the present invention, it further includes a second contraction section whose outer diameter gradually decreases from the fixed section to the working section.

In one of the embodiments of the present invention, the inner diameters of the working section and the fixed section are the same.

In one of the embodiments of the present invention, the outer surface of the thrombolytic tube is provided with an antibacterial coating.

In one embodiment of the present invention, the antibacterial coating is a silver-plated layer.

In one embodiment of the present invention, the outer surface of the thrombolytic tube is provided with an anticoagulant layer.

In one embodiment of the present invention, the anticoagulant layer is a heparin layer.

The present invention also discloses another thrombolytic tube, which includes a closed section, a working section and a fixed section arranged in sequence from the head end to the tail end, wherein the working section is provided with a liquid injection port for injecting liquid into the thrombolytic tube and A drug delivery hole for drug delivery to the lesion, the fixed section is detachably provided with a fixed knob, when the universal guide wire is inserted into the thrombolytic tube, the universal guide wire can close the entrance and the fixed section There is a drug delivery gap between the outlet of the closed section and the inner wall of the working section and the universal guide wire.

The present invention also discloses a thrombolytic tube assembly, including the thrombolytic tube as described in any one of the above and a general guide wire that can be inserted into the thrombolytic tube.

In one embodiment of the present invention, it further includes a spiral guide wire or a curved guide wire that can be inserted into the thrombolytic tube.

It can be seen from the above technical solutions that, in the thrombolytic tube of the present invention, when the universal guide wire is inserted into the thrombolytic tube, the universal guide wire can close the inlet of the fixed knob and the outlet of the closed section, And there is a drug delivery gap between the inner wall of the working section and the universal guide wire. That is to say, the thrombolytic tube of the present invention can use a universal guide wire, without the need to use a high-cost non-universal guide wire, which can achieve the purpose of smooth administration, and reduce the thrombolytic tube assembly in the treatment of clinical thrombosis. Therefore, the cost of clinical thrombosis treatment is reduced.

Description of the drawings

In order to explain the embodiments of the present invention or the technical solutions in the prior art more clearly, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only These are some embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained from these drawings without creative work.

Figure 1 is a schematic top view of a thrombolytic tube provided by an embodiment of the present invention;

Fig. 2 is a partial structural diagram of a thrombolytic tube provided by an embodiment of the present invention;

3 is a schematic top view of another thrombolytic tube provided by an embodiment of the present invention;

4 is a schematic top view of another thrombolytic tube provided by an embodiment of the present invention;

5 is a schematic top view of another thrombolytic tube provided by an embodiment of the present invention;

6 is a schematic top view of another thrombolytic tube provided by an embodiment of the present invention;

7 is a schematic top view of another thrombolytic tube provided by an embodiment of the present invention;

Figure 8 is a schematic top view of another thrombolytic tube provided by an embodiment of the present invention;

9 is a schematic top view of another thrombolytic tube provided by an embodiment of the present invention;

10 is a schematic diagram of a three-dimensional structure of a universal guide wire provided by an embodiment of the present invention;

FIG. 11 is a schematic diagram of a three-dimensional structure of another universal guide wire provided by an embodiment of the present invention.

In the figure, 100 is the thrombolytic tube, 101 is the closed section, 102 is the working section, 103 is the fixed section, 104 is the liquid injection port, 105 is the dosing hole, 106 positions the fixed knob, 107 positions the first contraction section, and 108 positions In the second contraction segment, 200 is a guide wire, 300 is a blood vessel, and 400 is a thrombus.

Detailed ways

According to the description of the background art, in the current thrombolysis tube assembly, the diameter of the thrombolysis tube is 5F (3F is about 1mm), and the non-universal guide wire is compatible with it. The diameter is 0.035", and the body part is thinner to ensure that when the non-universal guide wire is inserted into the thrombolytic tube, there is a gap between the non-universal guide wire and the thrombolytic tube. In this way, when the liquid is injected through the liquid injection port, the drug can smoothly pass through the gap and fully contact the thrombus through the administration hole. The manufacturing cost of non-universal guide wires is much higher than that of general guide wires. Since the size of the non-universal guide wire is not common with the size of the non-universal guide wire, the non-universal guide wire is not suitable for repeated use, resulting in waste of equipment.

To this end, the core of the present invention is to provide a thrombolytic tube and a thrombolytic tube assembly to reduce the cost of clinical thrombosis treatment.

In addition, the embodiments shown below do not limit the content of the invention described in the claims in any way. In addition, all the contents of the configuration shown in the following embodiments are not limited to what is necessary as a solution to the invention described in the claims.

1 to 2, the thrombolysis tube 100 in the embodiment of the present invention includes a closed section 101, a working section 102, and a fixed section 103 arranged in sequence from the head end to the tail end, wherein the working section 102 is provided with The injection port 104 of the plug tube 100 for injecting liquid and the drug hole 105 for drug delivery to the lesion. The fixed section 103 is detachably provided with a fixed knob 106. When the universal guide wire 200 is inserted into the thrombolytic catheter 100, the universal guide The wire 200 can close the inlet of the fixed knob 106 and the outlet of the closed section 101, and there is a drug delivery gap between the inner wall of the working section 102 and the universal guide wire 200.

In the thrombolytic tube 100 of the present invention, when the universal guide wire 200 is inserted into the thrombolytic tube 100, the universal guide wire 200 can close the inlet of the fixed knob 106 and the outlet of the closed section 101, and the inner wall of the working section 102 is the same as the universal guide wire 200. There is a dosing gap between. That is to say, the thrombolytic tube 100 of the present invention can use the universal guide wire 200 without the need to use the non-universal guide wire with higher cost, so that the purpose of smooth administration can be achieved, and the clinical thrombolysis 400 can be reduced during the treatment. The cost of the thrombus assembly reduces the treatment cost of the clinical thrombus 400.

In addition, in the prior art, the size of the thrombolytic tube 100 is 5F. Therefore, the drug solution has a relatively large pressure when passing through the administration hole 105, and the administration hole 105 is ejected to fully contact the thrombus 400. However, in this application, since the universal guide wire 200 is used, which is equivalent to increasing the diameter of the working section 102 of the thrombolytic tube 100, when the liquid medicine passes through the dosing hole 105, the pressure is lower than that of the prior art, and it is slowly ejected. In contact with the thrombus 400, and because the diameter of the working section 102 of the thrombolytic tube 100 is large, the effective contact area of the drug solution and the thrombus 400 is increased, and the enzymatic reaction is proportional to the contact area, thereby improving the therapeutic effect.

Since the thrombolytic tube 100 can use the universal guide wire 200, and the universal guide wire 200 can be reused, the waste of the universal guide wire 200 can be reduced.

It should be noted that the diameter of the working section 102 of the thrombolysis tube 100 in this case is increased compared to the diameter of the thrombolysis tube 100 in the prior art, and a size larger than 6F is generally adopted.

In order to reduce the resistance during insertion of the thrombolytic tube 100, the thrombolytic tube 100 in the present invention further includes a first contraction section 107 whose outer diameter gradually decreases from the working section 102 to the closed section 101. Therefore, the working section 102 and the closed section 101 can have a smoother transition, thereby reducing resistance when inserted into the blood vessel 300.

Similarly, it also includes a second contraction section 108 whose outer diameter gradually decreases from the fixed section 103 to the working section 102.

The inner diameters of the working section 102 and the fixed section 103 are the same or different. Preferably, the same inner diameter is used to facilitate processing.

Since the thrombolytic tube 100 has a relatively long residence time in the blood vessel 300, the outer surface of the thrombolytic tube 100 is provided with an antibacterial coating. The provision of an antibacterial coating can reduce the probability of bacterial growth, thereby reducing the risk of infection and prolonging the residence time of the thrombolytic tube 100. The antibacterial coating is a coating made of antibacterial materials, for example, the antibacterial coating is a silver-plated layer.

In addition, the thrombolytic tube 100 is in contact with blood in the blood vessel 300 for a long time. Therefore, the outer surface of the thrombolytic tube 100 is provided with an anticoagulant layer. By providing an anticoagulant layer, the probability of blood clotting can be reduced. The anticoagulant layer is processed from anticoagulant materials, for example, the anticoagulant layer is a heparin layer.

3, the thrombolytic tube 100 in the embodiment of the present invention includes a closed section 101, a working section 102, and a fixed section 103 arranged in sequence from the head end to the tail end, wherein the fixed section 103 is detachably provided with a fixed knob 106 The working section 102 is provided with a liquid injection port 104 and a dosing hole 105; when the universal guide wire 200 is inserted into the thrombolytic tube 100 by the fixed knob 106 in turn, the universal guide wire 200 can close the inlet of the fixed knob 106 and the sealing section 101 There is a drug delivery gap between the inner wall of the working section 102 and the universal guide wire 200. In the embodiment of the present invention, the working section 102 and the fixed section 103 are an integral structure; and the inner diameter of the exit of the closed section 101 gradually becomes smaller until it can fit with the universal guide wire 200.

4, the thrombolytic tube 100 in the embodiment of the present invention includes a closed section 101, a working section 102, and a fixed section 103 arranged in sequence from the head end to the tail end, wherein one end of the fixed section 103 is detachably provided with a fixed The knob 106, the other end of the fixed section 103 can be detachably arranged on the working section 102, and the side of the fixed section is provided with a liquid injection port 104 for injecting liquid into the thrombolytic tube 100, and the working section 102 is provided with a liquid injection port 104 for injecting liquid into the lesion The drug delivery hole 105 for drug delivery; when the universal guide wire 200 is inserted into the thrombolytic tube 100, the universal guide wire 200 can seal the inlet of the fixed knob 106 and the outlet of the closed section 101, and the fixed section 103 is provided with a liquid injection port 104 There is an administration gap between the position and the inner wall of the working section 102 and the universal guide wire 200.

As shown in Figure 5, the thrombolytic tube 100 in the embodiment of the present invention includes a closed section 101, a working section 102 and a fixed section 103 arranged in sequence from the head end to the tail end, wherein one end of the fixed section 103 is detachably provided with The fixed knob 106, the other end of the fixed section 103 can be detachably arranged on the working section 102, and the side of the fixed section is provided with a liquid injection port 104 for injecting liquid into the thrombolytic tube 100, and the working section 102 is provided with The drug delivery hole 105 for lesion administration; when the universal guide wire 200 is inserted into the thrombolytic tube 100, the universal guide wire 200 can seal the inlet of the fixed knob 106 and the outlet of the closed section 101, and the fixed section 103 is provided with a liquid injection port 104 There is a drug administration gap between the position of the inner wall of the working section 102 and the universal guide wire 200. In the embodiment of the present invention, the inner diameter of the exit of the closed section 101 gradually becomes smaller until it can fit with the universal guide wire 200.

Referring to FIG. 6, the thrombolytic tube 100 in the embodiment of the present invention includes a closed section 101, a working section 102, and a fixed section 103 arranged in sequence from the head end to the tail end, wherein one end of the fixed section 103 is detachably provided with a fixed Knob 106, the other end of the fixed section 103 is connected with the working section 102; the working section 102 is provided with a liquid injection port 104 for injecting liquid into the thrombolytic tube 100 and a drug delivery hole 105 for drug delivery to the lesion; When the guide wire 200 is inserted into the thrombolytic tube 100, the universal guide wire 200 can seal the inlet of the fixed section 103 and the outlet of the closed section 101, and there is a medication gap between the inner wall of the working section 102 and the universal guide wire 200. In the embodiment of the present invention, the working section 102 and the fixed section 103 are an integral structure; the inner diameter of the end of the fixed section 103 near the fixed knob 106 can be closed by the universal guide wire 200; the inner diameter of the exit of the closed section 101 is the same as the universal guide wire 200 The first contraction section 107 is adapted to be adapted and the outer radial closed section 101 of the working section 102 gradually becomes smaller.

Referring to FIG. 7, the thrombolytic tube 100 in the embodiment of the present invention includes a closed section 101, a working section 102, and a fixed section 103 arranged in sequence from the head end to the tail end, wherein one end of the fixed section 103 is detachably provided with a fixed Knob 106, the other end of the fixed section 103 is connected with the working section 102; the working section 102 is provided with a liquid injection port 104 for injecting liquid into the thrombolytic tube 100 and a drug delivery hole 105 for drug delivery to the lesion; When the guide wire 200 is inserted into the thrombolytic tube 100, the universal guide wire 200 can seal the inlet of the fixed section 103 and the outlet of the closed section 101, and there is a medication gap between the inner wall of the working section 102 and the universal guide wire 200. In the embodiment of the present invention, the working section 102 and the fixed section 103 are an integral structure; the inner diameter of the end of the fixed section 103 close to the fixed knob 106 can be closed by the universal guide wire 200; and the inner diameter of the exit of the closed section 101 gradually decreases until It can be matched with the universal guide wire 200.

Referring to FIG. 8, the thrombolytic tube 100 in the embodiment of the present invention includes a closed section 101, a working section 102 and a fixed section 103 arranged in sequence from the head end to the tail end, wherein one end of the fixed section 103 is detachably provided with a fixed The knob 106, the other end of the fixed section 103 can be detachably arranged on the working section 102, and the side of the fixed section is provided with a liquid injection port 104 for injecting liquid into the thrombolytic tube 100, and the working section 102 is provided with a liquid injection port 104 for injecting liquid into the lesion The drug delivery hole 105 for drug delivery; when the universal guide wire 200 is inserted into the thrombolytic tube 100, the universal guide wire 200 can seal the inlet of the fixed section 103 and the outlet of the closed section 101, and the inner wall of the working section 102 is the same as the universal guide wire 200 There is a dosing gap between. In the embodiment of the present invention, the inner diameter of the end of the fixed section 103 close to the fixed knob 106 can be closed by the universal guide wire 200; the inner diameter of the exit of the closed section 101 is adapted to the universal guide wire 200, and the outer diameter of the working section 102 The closed section 101 gradually becomes smaller in the first contraction section 107.

Referring to FIG. 9, the thrombolytic tube 100 in the embodiment of the present invention includes a closed section 101, a working section 102, and a fixed section 103 arranged in sequence from the head end to the tail end, wherein one end of the fixed section 103 is detachably provided with a fixed The knob 106, the other end of the fixed section 103 can be detachably arranged on the working section 102, and the side of the fixed section is provided with a liquid injection port 104 for injecting liquid into the thrombolytic tube 100, and the working section 102 is provided with a liquid injection port 104 for injecting liquid into the lesion The drug delivery hole 105 for drug delivery; when the universal guide wire 200 is inserted into the thrombolytic tube 100, the universal guide wire 200 can seal the inlet of the fixed section 103 and the outlet of the closed section 101, and the inner wall of the working section 102 is the same as the universal guide wire 200 There is a dosing gap between. In the embodiment of the present invention, the inner diameter of the end of the fixed section 103 close to the fixed knob 106 can be closed by the universal guide wire 200; and the inner diameter of the exit of the closed section 101 gradually decreases until it can fit with the universal guide wire 200.

The present invention also discloses a thrombolytic tube assembly, which includes the thrombolytic tube 100 as described above and a universal guide wire 200 that can be inserted into the thrombolytic tube 100. Since the above-mentioned thrombolytic tube 100 has the above beneficial effects, the thrombolytic tube assembly including the thrombolytic tube 100 has corresponding effects, which will not be repeated here.

Further, it also includes a spiral guide wire or a curved guide wire that can be inserted into the thrombolytic tube 100. Please refer to FIG. 10, the diameter of the spiral guide wire is the diameter of the universal guide wire 200. In the figure, the spiral guide wire is spirally wound around the oy. Because the spiral guide wire is inserted into the thrombolytic tube 100 under the premise of ensuring its hardness, the spiral guide wire 200 has a spiral structure, so it can drive the thrombolytic tube 100 to produce spiral deformation, thereby enabling Stirring the thrombus 400 at the blood vessel 300 produces a crushing effect, which further increases the contact area between the thrombolytic tube 100 and the thrombus 400, the liquid medicine and the thrombus 400, and accelerates the enzymatic reaction of the thrombus 400.

Please refer to Figure 11, in the figure the universal guide wire 200 is a curved guide wire, a part of the curved guide wire is bent in the first bend in the plane of zoy, and a part of the curved guide wire is bent in the second bend in the plane of xoy Part, the first curved part and the second curved part are alternately arranged. When the curved guide wire is used, the first bending part and the second bending part can rotate on different planes so as to stir the thrombus 400 at the blood vessel 300 to produce a crushing effect, and further increase the thrombolytic tube 100 and thrombus 400, liquid medicine and The contact area of thrombus 400 accelerates the enzymatic reaction of thrombus 400. Of course, in addition to the above-mentioned structure, the above-mentioned universal guide wire 200 can also have other structures, as long as its diameter is the diameter of the universal guide wire, all within the protection scope of the present invention.

The above description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be obvious to those skilled in the art, and the general principles defined in this document can be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown in this document, but should conform to the widest scope consistent with the principles and novel features disclosed in this document.

Claims

A thrombolytic tube, which is characterized by comprising a closed section, a working section and a fixed section arranged in order from the head end to the tail end, wherein the working section is provided with a liquid injection port for injecting liquid into the thrombolytic tube and For the drug delivery hole for drug delivery to the lesion, the fixed section is detachably provided with a fixed knob. When the universal guide wire is inserted into the thrombolytic tube, the universal guide wire can seal the inlet of the fixed knob and the The exit of the closed section is closed, and there is a drug delivery gap between the inner wall of the working section and the universal guide wire.
3. The thrombolytic tube of claim 1, further comprising a first contraction section whose outer diameter gradually decreases from the working section to the closed section.
3. The thrombolysis tube of claim 2, further comprising a second contraction section whose outer diameter gradually decreases from the fixed section to the working section.
The thrombolytic tube according to claim 3, wherein the inner diameter of the working section and the fixed section are the same.
The thrombolytic tube according to claim 1, wherein the outer surface of the thrombolytic tube is provided with an antibacterial coating.
The thrombolytic tube of claim 5, wherein the antibacterial coating is a silver-plated layer.
The thrombolytic tube according to claim 1, wherein the outer surface of the thrombolytic tube is provided with an anticoagulant layer.
8. The thrombolytic tube of claim 7, wherein the anticoagulant layer is a heparin layer.
A thrombolytic tube, which is characterized by comprising a closed section, a working section and a fixed section arranged in order from the head end to the tail end, wherein the working section is provided with a liquid injection port for injecting liquid into the thrombolytic tube and For the drug delivery hole for drug delivery to the lesion, the fixed section is detachably provided with a fixed knob. When the universal guide wire is inserted into the thrombolytic tube, the universal guide wire can seal the entrance of the fixed section and the The exit of the closed section is closed, and there is a drug delivery gap between the inner wall of the working section and the universal guide wire.
A thrombolytic tube assembly, which is characterized by comprising the thrombolytic tube according to any one of claims 1 to 9 and a universal guide wire that can be inserted into the thrombolytic tube.
10. The thrombolytic tube assembly of claim 10, further comprising a spiral guide wire or a curved guide wire that can be inserted into the thrombolytic tube.