WO2020241415A1 - Système d'évaluation de dose - Google Patents

Système d'évaluation de dose Download PDF

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Publication number
WO2020241415A1
WO2020241415A1 PCT/JP2020/019958 JP2020019958W WO2020241415A1 WO 2020241415 A1 WO2020241415 A1 WO 2020241415A1 JP 2020019958 W JP2020019958 W JP 2020019958W WO 2020241415 A1 WO2020241415 A1 WO 2020241415A1
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WO
WIPO (PCT)
Prior art keywords
value
dose
parameter
treatment
planned
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PCT/JP2020/019958
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English (en)
Japanese (ja)
Inventor
健蔵 佐々井
Original Assignee
住友重機械工業株式会社
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Application filed by 住友重機械工業株式会社 filed Critical 住友重機械工業株式会社
Priority to JP2021522267A priority Critical patent/JPWO2020241415A1/ja
Publication of WO2020241415A1 publication Critical patent/WO2020241415A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

Definitions

  • the present invention relates to a dose evaluation system.
  • the dose estimation unit further acquires the first parameter planned value planned in the treatment plan prepared in advance for the first parameter and the second parameter planned value planned in the treatment plan for the second parameter.
  • the dose estimated value may be acquired based on the first parameter planned value, the first parameter actual value, the second parameter planned value, and the second parameter actual value.
  • Dosage dose estimate J1 ⁇ ( ⁇ (R1 ⁇ R2) / ⁇ (P1 ⁇ P2)) + J2 ⁇ ( ⁇ R1 / ⁇ P1)... Equation (1)
  • ⁇ (R1 and R2) is the value obtained by integrating the product of the actual value of the first parameter and the actual value of the second parameter from the treatment start time to the treatment end time.
  • ⁇ (P1 and P2) is the time-integrated value of the product of the first parameter planned value and the second parameter planned value from the treatment start time to the treatment end time.
  • ⁇ R1 is the value obtained by integrating the actual value of the first parameter from the treatment start time to the treatment end time.
  • ⁇ P1 is a value obtained by integrating the first parameter planned value from the treatment start time to the treatment end time.
  • upstream and downstream mean upstream (accelerator side) and downstream (patient side) of the emitted charged particle beam and neutron beam, respectively.
  • the boron neutron capture therapy system 1 shown in FIG. 1 is a device for performing cancer treatment using boron neutron capture therapy (BNCT: BoronNCT), and is a patient (irradiated subject) 40 to which boron 10 ( 10 B) has been administered. Is irradiated with neutron beam N.
  • the boron neutron capture therapy system 1 includes an accelerator 10 (eg, a cyclotron), which accelerates a charged particle (eg, a proton) to produce and emit a charged particle beam P (eg, a proton beam).
  • the target T is irradiated with a charged particle beam P to generate a neutron beam N.
  • the target T here is formed of, for example, beryllium (Be) and has a disk shape having a diameter of 160 mm.
  • the type of the target T is set according to the energy of the charged particle beam P of the accelerator 10.
  • the moderator 50 decelerates the neutron beam N emitted from the target T and reduces the energy so as to be suitable for treatment.
  • the moderator 50 has, for example, a laminated structure made of a plurality of different materials.
  • the material of the moderator 50 is appropriately selected according to various conditions such as the energy of the charged particle beam.
  • a neutron beam N is generated when a proton beam collides with the target T, and the generated neutron beam N is decelerated by the moderator 50 and irradiated to the patient 40 through the opening 46a of the collimator 46.
  • the neutron beam N itself also damages the tumor.
  • the dose evaluation system 61 physically includes a CPU, RAM and ROM as main storage devices, auxiliary storage devices such as hard disks, input devices such as keyboards and mice as input devices, output devices such as displays, network cards, and the like. It is configured as a computer system that includes a communication module that is a data transmission / reception device of. Each function of the communication unit 61a, the calculation unit 61b, the display unit 61c, etc. included in the dose evaluation system 61 can also control the CPU by loading predetermined computer software on the hardware such as the CPU and RAM. This is achieved by operating the communication module, input device, and output device, and reading and writing data in the RAM and auxiliary storage device.
  • the control unit 57 (see FIG. 1) of the boron neutron capture therapy system 1 after the treatment receives the actual value R1 of the proton beam current actually emitted from the accelerator 10 at each time (for example, every second) during the treatment. It is stored as log data. That is, the proton beam current is measured by the current monitor 32, for example, at 1-second intervals, and the measured value from the treatment start time to the treatment end time, for example, every 1 second, is sent to the control unit 57 as an actual value R1 (first parameter actual value). Is accumulated and stored as.
  • the blood boron concentration during irradiation is assumed to decrease exponentially after the administration. It may be estimated. Further, it may be assumed that the blood boron concentration is constant throughout the irradiation of the neutron beam N.
  • the present invention can be implemented in various forms with various modifications and improvements based on the knowledge of those skilled in the art, including the above-described embodiment. It is also possible to construct a modified example by utilizing the technical matters described in the above-described embodiment. The configurations of the respective embodiments may be appropriately combined and used.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

L'invention porte sur un système d'évaluation de dose qui évalue, après un traitement, une dose administrée qui est une dose administrée à une tumeur d'un patient lors du traitement par un système de thérapie par capture de neutrons par le bore, une valeur réelle R1 indiquant une valeur d'un courant de faisceau de protons réel dans le traitement exécuté et une valeur réelle R2 d'une concentration réelle de bore dans le sang dans le traitement exécuté étant acquises, et une valeur d'estimation de dose administrée étant acquise sur la base d'informations concernant les valeurs acquises.
PCT/JP2020/019958 2019-05-30 2020-05-20 Système d'évaluation de dose WO2020241415A1 (fr)

Priority Applications (1)

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JP2021522267A JPWO2020241415A1 (fr) 2019-05-30 2020-05-20

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019-101555 2019-05-30
JP2019101555 2019-05-30

Publications (1)

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WO2020241415A1 true WO2020241415A1 (fr) 2020-12-03

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JP (1) JPWO2020241415A1 (fr)
WO (1) WO2020241415A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016159107A (ja) * 2015-03-05 2016-09-05 住友重機械工業株式会社 中性子捕捉療法装置
JP2019501737A (ja) * 2016-01-15 2019-01-24 南京中硼▲聯▼康医▲療▼科技有限公司Ｎｅｕｂｏｒｏｎ Ｍｅｄｔｅｃｈ Ｌｔｄ． 中性子捕捉療法システムに用いられる放射線検出システム及びその検出方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016159107A (ja) * 2015-03-05 2016-09-05 住友重機械工業株式会社 中性子捕捉療法装置
JP2019501737A (ja) * 2016-01-15 2019-01-24 南京中硼▲聯▼康医▲療▼科技有限公司Ｎｅｕｂｏｒｏｎ Ｍｅｄｔｅｃｈ Ｌｔｄ． 中性子捕捉療法システムに用いられる放射線検出システム及びその検出方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "annex 5 Evaluation index for accelerator-type neutron irradiation system for boron neutron capture therapy", MEDICINAL MACHINERY TRIAL 0523 NO. 2, vol. 5, 23 May 2019 (2019-05-23), pages 1 - 9, XP055766537, Retrieved from the Internet <URL:https://www.pmda.go.jp/files/000229738.pdf> [retrieved on 20200713] *
MATSUMOTO, TETSUO ET AL.: "Dose measuring system for boron neutron capture therapy", NUCLEAR INSTRUMENTS AND METHODS IN PHYSICS RESEARCH SECTION A: ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT, vol. 271, no. 3, 1 September 1988 (1988-09-01), pages 662 - 670, XP055538162, DOI: 10.1016/0168-9002(88)90337-3 *

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JPWO2020241415A1 (fr) 2020-12-03
TW202112414A (zh) 2021-04-01

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