WO2020197365A2 - Procédé de production de microparticules - Google Patents

Procédé de production de microparticules Download PDF

Info

Publication number
WO2020197365A2
WO2020197365A2 PCT/KR2020/095017 KR2020095017W WO2020197365A2 WO 2020197365 A2 WO2020197365 A2 WO 2020197365A2 KR 2020095017 W KR2020095017 W KR 2020095017W WO 2020197365 A2 WO2020197365 A2 WO 2020197365A2
Authority
WO
WIPO (PCT)
Prior art keywords
micro
mold
precursor solution
microparticles
cover substrate
Prior art date
Application number
PCT/KR2020/095017
Other languages
English (en)
Korean (ko)
Other versions
WO2020197365A9 (fr
WO2020197365A3 (fr
Inventor
봉기완
김현웅
Original Assignee
고려대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 고려대학교 산학협력단 filed Critical 고려대학교 산학협력단
Priority to US17/442,897 priority Critical patent/US20220195129A1/en
Publication of WO2020197365A2 publication Critical patent/WO2020197365A2/fr
Publication of WO2020197365A3 publication Critical patent/WO2020197365A3/fr
Publication of WO2020197365A9 publication Critical patent/WO2020197365A9/fr

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/38—Moulds or cores; Details thereof or accessories therefor characterised by the material or the manufacturing process
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/38—Moulds or cores; Details thereof or accessories therefor characterised by the material or the manufacturing process
    • B29C33/3842—Manufacturing moulds, e.g. shaping the mould surface by machining
    • B29C33/3857—Manufacturing moulds, e.g. shaping the mould surface by machining by making impressions of one or more parts of models, e.g. shaped articles and including possible subsequent assembly of the parts
    • B29C33/3878—Manufacturing moulds, e.g. shaping the mould surface by machining by making impressions of one or more parts of models, e.g. shaped articles and including possible subsequent assembly of the parts used as masters for making successive impressions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/70—Maintenance
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2823/00—Use of polyalkenes or derivatives thereof as mould material
    • B29K2823/04—Polymers of ethylene
    • B29K2823/06—PE, i.e. polyethylene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2875/00—Use of PU, i.e. polyureas or polyurethanes or derivatives thereof, as mould material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2883/00—Use of polymers having silicon, with or without sulfur, nitrogen, oxygen, or carbon only, in the main chain, as mould material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2901/00—Use of unspecified macromolecular compounds as mould material
    • B29K2901/10—Thermosetting resins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2901/00—Use of unspecified macromolecular compounds as mould material
    • B29K2901/12—Thermoplastic materials

Definitions

  • attaching a support plate to the other surface of the micro-mold and the other surface of the cover substrate may further include .
  • the micro-mold 10 prepared in the step of preparing the micro-mold and the cover substrate is made of a porous material.
  • the porous material is a polymer, for example, polydimethylsiloxane (PDMS), PDMS modified urethane acrylate (PUA), perfluoropolyether (PFPE), or polyethylene (PE), It may be a mixture of these.
  • PDMS polydimethylsiloxane
  • PDA PDMS modified urethane acrylate
  • PFPE perfluoropolyether
  • PE polyethylene
  • the material is not necessarily limited thereto, and may be used without limitation as long as it is a porous elastomer capable of permeating gas.
  • Micropatterns for synthesizing microparticles are designed using AutoCAD and printed on a photomask film.
  • a master mold is produced by curing SU-8, a negative photosensitive agent, in a general photolithography process.
  • a solution obtained by mixing PDMS and a curing agent in a ratio of 10:1 was poured into the master mold and then reduced in pressure in a vacuum chamber for 30 minutes to remove air bubbles, and then cured at 70°C for 4 hours.
  • the cured PDMS is removed from the master mold and cut into a specific size to form a micro mold.
  • the cover substrate is also manufactured using the same material, and the micro-mold and the cover substrate have a size of 1.5 ⁇ 1.5 cm and a thickness of 0.3 mm.
  • the micro-cavities of the micro mold are formed to be 100 (horizontal) ⁇ 100 (vertical) ⁇ 25 (depth) ⁇ m 3 .
  • FIG. 7B is an SEM image of the master mold prepared according to Example 1-2, and an SEM image of microparticles synthesized using a micromold based on the manufacturing and using the same, from which the micromold according to the present invention As a result, it can be seen that fine particles of a three-dimensional shape are elaborately synthesized.
  • FIG. 8 the results of evaluation by observing and evaluating the inhbition layer generated in the process of synthesizing microparticles according to Example 4 and Comparative Example 2 are shown.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Casting Or Compression Moulding Of Plastics Or The Like (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)

Abstract

La présente invention concerne un procédé destiné à la production de microparticules. Un procédé de préparation de microparticules selon un mode de réalisation de la présente invention comprend: (A) une étape de préparation d'un micro-moule poreux (10) et d'un substrat de couverture (20), le micro-moule poreux (10) ayant une pluralité de microcavités (11) en retrait concave selon une forme et une taille prédéterminées dans une surface de celui-ci; (b) une étape de dégazage du micro-moule (10) dans une chambre à vide (40); une étape de prélèvement du micro-moule dégazé (10) hors de la chambre à vide (40), et de mise en place d'une solution de précurseur de microparticules (50) entre une surface du micro-moule (10) et une surface du substrat de couverture (20) de manière à remplir avec la solution de précurseur de microparticules (50) l'intérieur des microcavités (11); (d) une étape de polymérisation d'un précurseur de microparticules dans la solution de précurseur de microparticules (50) pour synthétiser des microparticules (60); et (e) une étape de récupération des microparticules synthétisées (60).
PCT/KR2020/095017 2019-03-27 2020-03-05 Procédé de production de microparticules WO2020197365A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US17/442,897 US20220195129A1 (en) 2019-03-27 2020-03-05 Method for producing microparticles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020190034986A KR102196654B1 (ko) 2019-03-27 2019-03-27 미세입자 제조방법
KR10-2019-0034986 2019-03-27

Publications (3)

Publication Number Publication Date
WO2020197365A2 true WO2020197365A2 (fr) 2020-10-01
WO2020197365A3 WO2020197365A3 (fr) 2021-02-04
WO2020197365A9 WO2020197365A9 (fr) 2021-03-11

Family

ID=72610650

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2020/095017 WO2020197365A2 (fr) 2019-03-27 2020-03-05 Procédé de production de microparticules

Country Status (3)

Country Link
US (1) US20220195129A1 (fr)
KR (1) KR102196654B1 (fr)
WO (1) WO2020197365A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102602284B1 (ko) * 2020-12-30 2023-11-13 고려대학교 산학협력단 탈가스화된 기체투과성 마이크로 몰드와 불연속적 비젖음을 이용한 미세입자 제조방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4681718A (en) * 1984-05-09 1987-07-21 Hughes Aircraft Company Method of fabricating composite or encapsulated articles
JPS61502045A (ja) * 1984-05-09 1986-09-18 ヒユ−ズ・エアクラフト・カンパニ− 複合体あるいは被覆体製品の製造方法
US7077986B2 (en) * 2000-09-29 2006-07-18 Jsr Corporation Method for formation of polymer
JP2002172645A (ja) * 2000-09-29 2002-06-18 Jsr Corp ポリマーの成形方法
KR101171034B1 (ko) * 2008-10-28 2012-08-03 포항공과대학교 산학협력단 3차원 구조체, 그 제조 방법 및 제조 장치
KR101399013B1 (ko) 2012-03-22 2014-06-19 충남대학교산학협력단 복제몰드의 팽윤에 의한 마이크로입자의 제조방법
KR101526675B1 (ko) * 2013-07-29 2015-06-09 국립대학법인 울산과학기술대학교 산학협력단 미세 입자 제조장치 및 이를 이용한 바이오물질이 캡슐된 미세 입자 제조방법
KR101612093B1 (ko) * 2015-04-17 2016-04-12 충남대학교산학협력단 복제몰드의 형상 개질 방법 및 이에 의한 단분산성 마이크로 입자의 제조 방법

Also Published As

Publication number Publication date
WO2020197365A9 (fr) 2021-03-11
US20220195129A1 (en) 2022-06-23
KR20200113980A (ko) 2020-10-07
KR102196654B1 (ko) 2020-12-30
WO2020197365A3 (fr) 2021-02-04

Similar Documents

Publication Publication Date Title
US6805809B2 (en) Decal transfer microfabrication
JP4990479B2 (ja) 多層リソグラフィープロセスに関する新規な平坦化方法
WO2012070833A2 (fr) Composition de résine durcissable sous l'action d'un rayonnement et procédé de fabrication d'un moule auto-réplicable l'utilisant
KR20010030001A (ko) 디바이스제조를 위한 리소그래피 공정
WO2016114622A1 (fr) Microstructure hiérarchique, moule pour la fabrication de celle-ci, et procédé de fabrication du moule
WO2015183008A1 (fr) Procédé de revêtement à l'aide d'un alignement de particules
WO2020197365A2 (fr) Procédé de production de microparticules
CN105378563B (zh) 图案化印模制造方法、图案化印模压印方法以及压印物品
WO2011016651A9 (fr) Composition de résine photodurcissable pour lithographie d'impression et procédé de fabrication d'un moule d'impression l'utilisant
TWI764926B (zh) 產生壓印無殘餘基板表面之方法和流量槽
US20070257396A1 (en) Device and method of forming nanoimprinted structures
KR100760480B1 (ko) 미세 패턴을 구비한 폴리머 시트를 제작하는 방법
US20070210483A1 (en) Mold made of amorphous fluorine resin and fabrication method thereof
CN110187417B (zh) Pdms薄膜微透镜阵列的制作方法
WO2022145962A1 (fr) Procédé de fabrication de microparticules à l'aide de micro-moule perméable aux gaz dégazé et de démouillage discontinu
KR101636450B1 (ko) 전도성 접착제 필름의 제조방법 및 이에 따라 제조되는 전도성 접착제 필름
CN111240151B (zh) 模板转印方法
KR100526053B1 (ko) 비결정성 불소 수지를 이용한 주형 및 그 제조 방법
Han et al. Solvent-assisted polymer micro-molding
Le Berre et al. Micro-aspiration assisted lithography
Marczak et al. Soft lithography processing of fresnel lens for on-chip applications
KR100667471B1 (ko) 분리 격벽 제조용 몰드 및 이를 이용한 이중층 분리격벽의 제조 방법
WO2015064816A1 (fr) Procédé de fabrication de microlevier
US9050740B2 (en) Forming non-uniform optical guiding structures
US7988899B2 (en) Stamper and method for making soft mold

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 20778389

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 20778389

Country of ref document: EP

Kind code of ref document: A2