WO2020197101A3 - 이중 약물 방출을 위한 약물 전달체 - Google Patents

이중 약물 방출을 위한 약물 전달체 Download PDF

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Publication number
WO2020197101A3
WO2020197101A3 PCT/KR2020/002545 KR2020002545W WO2020197101A3 WO 2020197101 A3 WO2020197101 A3 WO 2020197101A3 KR 2020002545 W KR2020002545 W KR 2020002545W WO 2020197101 A3 WO2020197101 A3 WO 2020197101A3
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drug
dual
carrier
release
drug carrier
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PCT/KR2020/002545
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English (en)
French (fr)
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WO2020197101A2 (ko
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원재연
박영훈
조동우
김종민
가오그
김지수
장진아
Original Assignee
가톨릭대학교산학협력단
포항공과대학교 산학협력단
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Publication of WO2020197101A2 publication Critical patent/WO2020197101A2/ko
Publication of WO2020197101A3 publication Critical patent/WO2020197101A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

본 발명은 이중 약물 방출을 위한 약물 전달체에 관한 것으로, 더욱 상세하게는 제1 약물과 제1 생체 적합성 고분자가 혼합된 코어 로드(core rod) 및, 제2 약물과 제2 생체 적합성 고분자가 혼입된 쉘(shell) 구조에 의해 약물이 순차적으로 방출될 뿐만 아니라 지속적으로 방출될 수 있는 약물 전달체에 관한 것이다. 본 발명에 따른 약물 전달체에 따르면, 이중 약물이 순차적/지속적으로 방출될 수 있도록 함으로써 약물 투여 횟수를 줄일 수 있으며, 이에 따라 부작용도 최소화할 수 있다.
PCT/KR2020/002545 2019-03-26 2020-02-21 이중 약물 방출을 위한 약물 전달체 WO2020197101A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2019-0034479 2019-03-26
KR1020190034479A KR102183669B1 (ko) 2019-03-26 2019-03-26 이중 약물 방출을 위한 약물 전달체

Publications (2)

Publication Number Publication Date
WO2020197101A2 WO2020197101A2 (ko) 2020-10-01
WO2020197101A3 true WO2020197101A3 (ko) 2020-11-19

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PCT/KR2020/002545 WO2020197101A2 (ko) 2019-03-26 2020-02-21 이중 약물 방출을 위한 약물 전달체

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KR (1) KR102183669B1 (ko)
WO (1) WO2020197101A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102637156B1 (ko) * 2021-11-05 2024-02-16 주식회사 지투지바이오 비경구 병용투여용 약학적 키트

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011035013A2 (en) * 2009-09-17 2011-03-24 Surmodics Pharmaceuticals, Inc. Implant devices that differ by release profile and methods of making and using same
WO2011037955A1 (en) * 2009-09-22 2011-03-31 Surmodics Pharmaceuticals, Inc. Implant devices for modulating bioactive agent release profiles
WO2011037953A2 (en) * 2009-09-22 2011-03-31 Surmodics Pharmaceuticals, Inc. Implant devices having varying bioactive agent loading configurations
WO2011116132A1 (en) * 2010-03-16 2011-09-22 Titan Pharmaceuticals, Inc. Heterogeneous implantable devices for drug delivery
KR20110118859A (ko) * 2010-04-26 2011-11-02 한국과학기술연구원 코어-쉘 구조의 성장인자 전달체, 그의 제조방법 및 세포 분화 또는 증식을 위한 그의 용도
KR20160083779A (ko) * 2014-12-31 2016-07-12 중앙대학교 산학협력단 약물 방출 조절이 가능한 스캐폴드
US9572780B2 (en) * 2003-07-18 2017-02-21 Depomed, Inc. Dual drug dosage forms with improved separation of drugs
US20180264179A1 (en) * 2017-03-19 2018-09-20 Biohealthways, Inc. Biodegrading implantable ocular sustained release drug delivery system

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101809939B1 (ko) 2016-09-27 2017-12-18 울산과학기술원 친수성 및 소수성 약물의 순차적 방출을 위한 나노 약물 전달체

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9572780B2 (en) * 2003-07-18 2017-02-21 Depomed, Inc. Dual drug dosage forms with improved separation of drugs
WO2011035013A2 (en) * 2009-09-17 2011-03-24 Surmodics Pharmaceuticals, Inc. Implant devices that differ by release profile and methods of making and using same
WO2011037955A1 (en) * 2009-09-22 2011-03-31 Surmodics Pharmaceuticals, Inc. Implant devices for modulating bioactive agent release profiles
WO2011037953A2 (en) * 2009-09-22 2011-03-31 Surmodics Pharmaceuticals, Inc. Implant devices having varying bioactive agent loading configurations
WO2011116132A1 (en) * 2010-03-16 2011-09-22 Titan Pharmaceuticals, Inc. Heterogeneous implantable devices for drug delivery
KR20110118859A (ko) * 2010-04-26 2011-11-02 한국과학기술연구원 코어-쉘 구조의 성장인자 전달체, 그의 제조방법 및 세포 분화 또는 증식을 위한 그의 용도
KR20160083779A (ko) * 2014-12-31 2016-07-12 중앙대학교 산학협력단 약물 방출 조절이 가능한 스캐폴드
US20180264179A1 (en) * 2017-03-19 2018-09-20 Biohealthways, Inc. Biodegrading implantable ocular sustained release drug delivery system

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DE SOUZA, S. O. ET AL.: "Biodegradable core-shell electrospun nanofibers containing bevacizumab to treat age-related macular degeneration", JOURNAL OF MATERIALS SCIENCE : MATERIALS IN MEDICINE, vol. 29, no. 173, 2018, pages 1 - 11, XP036652818, DOI: 10.1007/s10856-018-6187-5 *

Also Published As

Publication number Publication date
KR20200113784A (ko) 2020-10-07
WO2020197101A2 (ko) 2020-10-01
KR102183669B1 (ko) 2020-11-26

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