WO2020129342A1 - Système de génération de substance organique - Google Patents

Système de génération de substance organique Download PDF

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Publication number
WO2020129342A1
WO2020129342A1 PCT/JP2019/037334 JP2019037334W WO2020129342A1 WO 2020129342 A1 WO2020129342 A1 WO 2020129342A1 JP 2019037334 W JP2019037334 W JP 2019037334W WO 2020129342 A1 WO2020129342 A1 WO 2020129342A1
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WO
WIPO (PCT)
Prior art keywords
liquid
organic substance
supply
microorganism
line
Prior art date
Application number
PCT/JP2019/037334
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English (en)
Japanese (ja)
Inventor
典秀 西山
清水　諭
ディブリーナ ロイ
Original Assignee
積水化学工業株式会社
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Publication date
Application filed by 積水化学工業株式会社 filed Critical 積水化学工業株式会社
Publication of WO2020129342A1 publication Critical patent/WO2020129342A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/12—Apparatus for enzymology or microbiology with sterilisation, filtration or dialysis means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes

Definitions

  • the supply line further has a bypass line provided in parallel with the first supply line and the second supply line, The bypass line bypasses the first microorganism removal device and the second microorganism removal device, You may do it.
  • the temperature inside the distiller 181 during the distillation of the organic substance (particularly ethanol) is not particularly limited, but is preferably 100° C. or lower, more preferably about 70° C. to 95° C. By setting the temperature in the distiller 181 within this range, the required organic substance and other components can be separated, that is, the organic substance can be distilled (purified) more reliably.
  • the organic substance production system 10 in the present embodiment further includes a gas-liquid separation device 60 for separating the separated liquid from the above-mentioned exhaust gas discharged from the fermenter 161.
  • the gas-liquid separation device 60 is connected to the fermenter 161 via the discharge pipe 168 described above.
  • the exhaust gas discharged from the fermenter 161 contains the water content of the microorganism culture solution.
  • the gas-liquid separation device 60 is configured to separate the water contained in the exhaust gas as a separation liquid from the exhaust gas.
  • the separated liquid separated in the gas-liquid separation device 60 is returned to the fermenter 161 via the gas-liquid separation return line 62.
  • the gas-liquid separation return line 62 may be provided with a pump (not shown) that sends the separated liquid to the fermentation tank 161.
  • the first microorganism removing device 42 can be washed while the second microorganism removing device 44 is removing microorganisms from the supply liquid.
  • the first introduction valve 224 and the first drain valve 226, for example, by driving the introduction pump (not shown) provided in the first introduction line 223, the first introduction line
  • the backwashing fluid is introduced from 223 to the first supply line 22. Since the first outlet valve 222 is closed, the introduced backwashing fluid first flows into the first filtrate storage section 422, and then passes through the first filter 421. Since the first inlet valve 221 is closed and the first drain valve 226 is opened, the backwashing fluid that has passed through the first filter 421 is discharged from the first drain line 225.
  • the introduction lines 223 and 243 for introducing the backwashing fluid supplied to the microorganism removal device 40 are connected to the portion of the supply line 20 on the downstream side of the microorganism removal device 40
  • Drain lines 225 and 245 for discharging the backwashing fluid that has passed through the microorganism removing device 40 are connected to a portion of the supply line 20 on the upstream side of the microorganism removing device 40. This allows the backwashing fluid to flow through the filters 421 and 441 of the microorganism removing device 40 in the direction opposite to the direction in which the supply liquid flows when cleaning the microorganism removing device 40.
  • the mixed liquid may be cooled using the cooler 70 (see FIGS. 9 and 10) before flowing into the fermenter 161.
  • the residual liquid recycling line 52 may be provided with a pump (not shown) that sends the residual liquid to the microorganism removing device 40. Further, the outlet end of the residual liquid recycling line 52 may be connected to any part of the supply line 20 as long as the residual liquid separated by the distiller 181 can be supplied to the microorganism removing device 40. Furthermore, the outlet end of the residual liquid recycling line 52 may be connected to the liquid supply source 30. In this case, the distillate is supplied from the liquid supply source 30 to the microorganism removing device 40 together with the supply liquid.
  • the residual liquid is heated to a high temperature in the distiller 181, and has already been sterilized or sterilized in the distiller 181, and at least a part of the microorganisms contained in the residual liquid has been killed or inactivated.
  • the filters 421 and 441 it is possible to further suppress the inclusion of microorganisms in the mixed liquid supplied to the fermenter 161.
  • the distiller 181 (separation device) is provided with an organic substance-containing liquid (exhaust fluid) containing the organic substance discharged from the fermentation tank 161 of the organic substance generator 16.
  • the residual liquid (separation liquid) is separated.
  • the residual liquid discharged from the distiller 181 is supplied to the fermenter 161 by the distillation return line 50.
  • the microorganisms contained in the residual liquid are removed by the microorganism removal device 40 provided in the distillation return line 50.
  • FIG. 12 shows an example in which the supply line 20 is not provided with the microorganism removing device 40, the supply line 20 may be additionally provided with the microorganism removing device 40.
  • the inactivation section provided in the distillation return line 50 may be constituted by the distillation return line 50 itself. That is, the residual liquid heated to a high temperature in the distiller 181 is maintained in a high temperature state and sterilized or sterilized while flowing through the distillation return line 50 (here, the high temperature state means at least This means a state in which the temperature is higher than the temperature of the microorganism culture solution in the fermenter 161, and if at least a part of the microorganisms can be killed or inactivated, the temperature decrease is allowed while flowing through the distillation return line 50. ). As a result, at least some of the microorganisms contained in the residual liquid are killed or inactivated while flowing through the distillation return line 50.

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Un dispositif de génération de substance organique comprend : un dispositif de génération de substance organique ayant un récipient qui contient un bouillon de culture microbienne; et une ligne d'alimentation qui fournit du liquide au récipient. La ligne d'alimentation est pourvue d'un dispositif d'élimination de micro-organismes qui élimine un micro-organisme contenu dans le liquide fourni.
PCT/JP2019/037334 2018-12-18 2019-09-24 Système de génération de substance organique WO2020129342A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018236600 2018-12-18
JP2018-236600 2018-12-18

Publications (1)

Publication Number Publication Date
WO2020129342A1 true WO2020129342A1 (fr) 2020-06-25

Family

ID=71102724

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Application Number Title Priority Date Filing Date
PCT/JP2019/037334 WO2020129342A1 (fr) 2018-12-18 2019-09-24 Système de génération de substance organique

Country Status (1)

Country Link
WO (1) WO2020129342A1 (fr)

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01211484A (ja) * 1988-02-19 1989-08-24 Kokuritsu Kogai Kenkyusho 無菌大量培養方法とその装置
JPH03247267A (ja) * 1990-02-26 1991-11-05 Agency Of Ind Science & Technol 好気性培養装置
JPH04211357A (ja) * 1990-03-16 1992-08-03 Hitachi Ltd 連続培養方法及び装置
JPH08172956A (ja) * 1994-12-28 1996-07-09 Tokimec Inc 培養装置及びその培地交換方法
JP2002051763A (ja) * 2000-08-08 2002-02-19 Ajinomoto Co Inc 好気性培養における培養装置及び消泡制御方法
JP2004504058A (ja) * 2000-07-25 2004-02-12 バイオエンジニアリング・リソーシズ・インコーポレーテツド 微生物発酵によるエタノール生産を向上させる方法
JP2009065970A (ja) * 2007-08-22 2009-04-02 Toray Ind Inc 連続発酵による化学品の製造方法
JP2011211961A (ja) * 2010-03-31 2011-10-27 Honda Motor Co Ltd ろ過装置
WO2012086720A1 (fr) * 2010-12-22 2012-06-28 東レ株式会社 Procédé de production d'une substance chimique par fermentation continue
JP2014050406A (ja) * 2009-04-29 2014-03-20 Lanzatech New Zealand Ltd 発酵における改善された炭素捕捉
WO2016043163A1 (fr) * 2014-09-19 2016-03-24 積水化学工業株式会社 Procédé de culture de micro-organismes et dispositif associé
JP2016111986A (ja) * 2014-12-17 2016-06-23 積水化学工業株式会社 培養装置及び方法

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01211484A (ja) * 1988-02-19 1989-08-24 Kokuritsu Kogai Kenkyusho 無菌大量培養方法とその装置
JPH03247267A (ja) * 1990-02-26 1991-11-05 Agency Of Ind Science & Technol 好気性培養装置
JPH04211357A (ja) * 1990-03-16 1992-08-03 Hitachi Ltd 連続培養方法及び装置
JPH08172956A (ja) * 1994-12-28 1996-07-09 Tokimec Inc 培養装置及びその培地交換方法
JP2004504058A (ja) * 2000-07-25 2004-02-12 バイオエンジニアリング・リソーシズ・インコーポレーテツド 微生物発酵によるエタノール生産を向上させる方法
JP2002051763A (ja) * 2000-08-08 2002-02-19 Ajinomoto Co Inc 好気性培養における培養装置及び消泡制御方法
JP2009065970A (ja) * 2007-08-22 2009-04-02 Toray Ind Inc 連続発酵による化学品の製造方法
JP2014050406A (ja) * 2009-04-29 2014-03-20 Lanzatech New Zealand Ltd 発酵における改善された炭素捕捉
JP2011211961A (ja) * 2010-03-31 2011-10-27 Honda Motor Co Ltd ろ過装置
WO2012086720A1 (fr) * 2010-12-22 2012-06-28 東レ株式会社 Procédé de production d'une substance chimique par fermentation continue
WO2016043163A1 (fr) * 2014-09-19 2016-03-24 積水化学工業株式会社 Procédé de culture de micro-organismes et dispositif associé
JP2016111986A (ja) * 2014-12-17 2016-06-23 積水化学工業株式会社 培養装置及び方法

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