WO2020107650A1

WO2020107650A1 - Cryogenic transport device

Info

Publication number: WO2020107650A1
Application number: PCT/CN2019/070358
Authority: WO
Inventors: 瞿建国; 罗沉; 王建信
Original assignee: 上海原能细胞生物低温设备有限公司
Priority date: 2018-11-28
Filing date: 2019-01-04
Publication date: 2020-06-04
Also published as: JP3236649U; CN209284108U

Abstract

A cryogenic transport device comprises a tank, an absorption material, a holding member and a tank cover. The absorption material is provided inside the tank. The holding member is provided above the absorption material, and comprises a holding portion and an accommodation portion. A cryopreserved container can be placed in the holding portion. Multiple cooling holes extend through the holding portion and the accommodation portion. The tank cover is provided at the tank. A vacuum hollow layer is arranged inside an inner wall of the tank. An annular positioning and supporting member is provided inside the tank to position and support the holding member in the tank. The annular positioning and supporting member is provided with a ball-shaped positioning member extending toward the interior of the tank. The device further comprises a control device used to detect, store and display a temperature inside the tank.

Description

Deep low temperature transfer device

Technical field

The utility model relates to the field of biological sample storage, extraction and transfer equipment, in particular to a cryogenic transfer device.

Background technique

The cryogenic biological sample library is an important basic equipment for research in the pharmaceutical and biological fields. The cryopreservation of liquid nitrogen can keep biological tissues such as blood, stem cells and immune cells active for a long time. After obtaining the biological samples, store the biological samples one by one in each cryopreservation tube, and then place the cryopreservation tube in the cryopreservation box to transfer the biological sample to the cryogenic storage tank for preservation; in the prior art, the cryopreservation box is targeted The process of transferring to cryogenic storage tanks is to use ordinary jars, which are not as good as liquid nitrogen, to temporarily cool the jars to temporarily stay in the cryogenic environment, and then put the frozen storage box into it for transshipment; this This kind of transfer method poses a greater risk to the biological samples of cryopreservation tubes in the cryopreservation box and cannot maintain a deep cryogenic environment; the prior art also discloses the patent number: 2016112378301 as an example, although the liquid nitrogen tank is provided with The flexible liquid nitrogen adsorption block is used to adsorb liquid nitrogen, but there is a large distance between the flexible liquid nitrogen adsorption block and the sample rack where the cryotube is placed, which has great limitations on the cooling of the cryotube, and also freezes during the transfer process The storage tube cannot detect the ambient temperature in the tank, and the temperature change has an undetectable effect on the deep and low temperature environment in the tank.

technical problem

The purpose of the utility model is to provide a deep and low temperature transfer device, which can maintain the low temperature environment for a long time, effectively monitor the environment of the frozen storage tube in the tank during the transfer process, and also effectively detect the temperature in the tank and perform intelligent operation. Ensure the safety of biological sample transfer.

Technical solution

The utility model solves the technical problem by adopting the following technical scheme: a deep and low temperature transfer device, including a tank body, an adsorption material, a holding member and a tank cover; the adsorption material is provided in the tank body, and the holding member is provided in Above the adsorbent material, and the holding member is provided with a plurality of cooling holes, and the holding member can store a frozen storage box; the can lid is provided on the can body, and the can body Inside the tank wall is the vacuum chamber layer.

Preferably, the containing member includes a containing part and a containing part, the adsorption material may be located in the containing part, the freezing box may be placed in the containing part, and the containing part A plurality of cooling holes are penetrated through the storage container.

Preferably, the end face of the adsorbent material is recessed with a base receiving groove; the holding member includes a holding plate, a holding plate ring and a holding support ring; the lower end of the holding plate ring is fixed on the holding A circumferential periphery of the placing plate, and a plurality of cooling holes formed in a honeycomb shape are formed on the placing plate, and a plurality of circumferential cooling channels of a circumferential array are provided on the placing plate ring; A connecting plate ring is extended on the outer periphery of the upper end, and the other end of the connecting plate ring is vertically provided with a holding support ring; the holding support ring and the lower end surface of the holding plate and the holding plate ring form a holding container The holding plate ring and the upper surface of the holding plate form a holding groove as a holding portion.

Optionally, the holding member includes a holding A plate and a holding A support ring, and the circumferential periphery of the holding A plate is vertically fixed to the upper end of the holding A support ring; the holding A plate is opened There are a plurality of cooling holes; the upper end surface of the A-board is formed into a receiving portion; the lower end surface of the A-board is enclosed with the A-supporting ring to form a receiving portion.

Preferably, a positioning support ring strip is provided in the tank body, and a positioning ball plug is extended on the positioning support ring strip to the tank body; the positioning support ring strip positions and supports the containing member in the tank body.

Preferably, it further includes a control device, which can detect, record and display the temperature in the tank.

Preferably, it further includes a tank base, and the tank is disposed on the tank base.

Preferably, it further includes a battery, the battery is provided at the bottom of the tank base, and the battery is electrically connected to the control device;

The control device includes a control circuit board, a display, a temperature sensor and an alarm;

The temperature sensor senses the temperature in the tank, and the temperature sensor is electrically connected to the control circuit board, the control circuit board is electrically connected to the display, and the display is provided outside the tank ; The alarm is electrically connected to the control circuit board.

Preferably, the can lid includes a can lid body and a sealed foam lid, the can lid body cover is provided on the can body, and the can lid body extends with a sealed foam cover extending into the can body, the sealed foam The lid is sealed to the tank.

Preferably, it also includes a reinforced outer ring plate, a sleeve plate and a handle;

The reinforced outer ring plate ring sleeve is fixed on the periphery of the tank body, the sleeve plate ring sleeve is fixed on the periphery of the reinforced outer ring plate, and the handle is provided on the sleeve plate.

Beneficial effect

The utility model has the following beneficial effects: the tank is provided with an adsorbent material, and at the same time is provided with a containing member covered on the adsorbent material, the containing member is provided with a plurality of cooling holes, and the frozen member can be placed on Storage box, the adsorption material can keep the absorbed liquid nitrogen through the cooling hole to maintain the deep low temperature of the frozen storage box, and maintain the low temperature environment for a long time. On the frozen storage box, the safety of biological sample transfer is improved.

BRIEF DESCRIPTION

Figure 1 is a schematic diagram of the structure of the cryogenic transfer device;

Figure 2 is an exploded view of the cryogenic transfer device;

Figure 3 is a schematic structural view of the positioning support ring strip provided on the tank;

4 is an enlarged view of part A of FIG. 3;

FIG. 5 is a cross-sectional view when a holding member is provided in the cryogenic transfer device, which includes the holding A plate;

6 is a cross-sectional view of a storage member provided in a cryogenic transfer device including a storage plate;

7 is a schematic structural view of a container member according to an embodiment from a top view;

8 is a schematic structural view of the holding member of FIG. 7 from a bottom view;

9 is a cross-sectional view of the holding member of FIG. 7;

FIG. 10 is a schematic structural view of a container member according to another embodiment.

The symbols in the figure are: 1- tank; 2-adsorption material; 3-container; 4-cap; 5-cooling hole; 6-freeze box; 7-housing; 8-housing ; 9-base receiving slot; 10-holding plate; 11-holding plate ring; 12-holding support ring; 13-cooling channel; 14-connecting plate ring; 15-holding groove; 16-holding A plate ; 17- A support ring; 18- positioning support ring strip; 19- positioning ball plug; 20- control device; 21- tank base; 22- vacuum chamber layer; 23- battery; 24- display; 25- Temperature sensor; 26-tank cover body; 27-sealed foam cover; 28-reinforced outer ring plate; 29-sleeve ring plate; 30-handle.

Best Mode of the Invention

The technical solution of the present invention will be further elaborated below with reference to embodiments and drawings.

Example 1

This embodiment provides a deep and low temperature transfer device, including a tank body 1, an adsorbent material 2, a holding member 3, and a tank lid 4; the adsorbent material 2 is disposed in the tank body 1, and the holding member 3 It is provided above the adsorption material 2, and the containing member 3 is provided with a plurality of cooling holes 5, and the containing member 3 can store a frozen storage box 6; the can lid 4 is provided on the can On the body 1, and inside the tank wall of the tank body 1 is a vacuum chamber layer 22.

Whether it is a single or multiple or multiple frozen storage tubes, when it is necessary to transfer the frozen storage tubes, the tank 1 is now filled with a sufficient amount of liquid nitrogen, and the frozen storage box 6 containing the frozen storage tubes is placed in the storage Put the lid 4 on the component 3 and transport it; because the adsorbent material 2 is made of adsorbent material, it can adsorb liquid nitrogen, because after the adsorbent material 2 absorbs enough liquid nitrogen, there are many Cooling holes 5, the cooling holes 5 are through holes, the liquid nitrogen absorbed on the adsorbent 2 will be distributed through the hole cooling holes 5 to and above the holding member 3, so that the freezing box placed on the holding member 3 6 has been in a deep low temperature environment; and because of the arrangement of the holding member 3, the liquid nitrogen and the cryopreservation box 6 are effectively and directly contacted, which ensures the stability of the cryopreservation tube environment and improves the safety of biological sample transfer. The inside of the tank wall is a vacuum cavity layer, which increases the insulation between the inside of the tank and the outside of the tank, and enhances the effect of heat insulation.

In a preferred further implementation of this embodiment, the holding member 3 includes a holding portion 7 and a holding container 8, the adsorption material 2 may be located in the holding container 8, and the freezing box 6 may be held A plurality of cooling holes 5 are provided through the housing portion 7 and between the housing portion 7 and the housing portion 8. This setting further makes the cryotube and liquid nitrogen more direct and effective contact, the environment is more stable.

In this embodiment, an embodiment of the holding member 3 and the adsorbing material 2 is preferred. The adsorbing material 2 is provided with a base receiving groove 9 recessed at the end face; the holding member 3 includes a holding plate 10 and a holding plate ring 11 and a holding support ring 12; the lower end of the holding plate ring 11 is fixed on the periphery of the circumference of the holding plate 10, and the holding plate 10 is provided with a plurality of honeycomb-shaped cooling holes 5, so The holding plate ring 11 is provided with a plurality of vertical cooling channels 13 in a circumferential array; the upper end circumference of the holding plate ring 11 is extended with a connecting plate ring 14 and the other end of the connecting plate ring 14 is facing A supporting ring 12 is vertically arranged below; the supporting ring 12 and the lower end surface of the holding plate 10 and the holding plate ring 11 form a holding container 8; the holding plate ring 11 and the holding ring The upper end surface of the board 10 is formed with a receiving groove 15 as a receiving portion.

The holding groove 15 formed by the holding plate ring 11 and the holding plate 10 just falls into the base receiving groove 9 of the adsorbent material 2, and the adsorbent material 2 is located exactly in the containing container 8; the holding plate ring 11 is opened There are a plurality of vertical cooling channels 13 in a circumferential array, and a plurality of cooling holes 5 in a honeycomb shape are opened on the holding plate 10; so that the freezing box 6 placed in the holding groove 15 not only holds the holding plate 10 from below It can also be received from the cooling channel 13 of the plate ring 11, so that the cooled liquid nitrogen can be received in the circumferential direction, which greatly enhances the effectiveness and stability of the cold environment.

This embodiment also discloses another implementation manner of the holding member 3, the holding member 3 includes a holding A plate 16 and a holding A support ring 17, the outer circumference of the holding A plate 16 and the periphery The upper end of the holding A support ring 17 is vertically fixed; the holding A plate 16 is provided with a plurality of cooling holes 5; the upper end surface of the holding A plate 16 forms a holding portion 7; The lower end surface surrounds the holding A support ring 17 to form a holding container 8. This arrangement also makes the cryopreservation tube directly and effectively contact with the adsorbent material 2 and can hold more cryopreservation tubes.

In a preferred further implementation of this embodiment, a positioning support ring strip 18 is provided in the tank 1, and a positioning ball plug 19 is provided on the positioning support ring strip 18 extending into the tank body; the positioning support ring strip 18 The holding member 3 is positioned and supported in the can body 1. When the storage member 3 is provided, the position of the storage member 3 can be determined according to the positioning support ring 18, and the positioning ball head plug 19 is used to give the storage member 3 a radial upward supporting force to increase the storage member 3. Stability.

A preferred further implementation of this embodiment further includes a control device 20, which can detect, record, and display the temperature in the tank. A control device 20 is provided. During the transfer process, the transfer time and the temperature in the tank 1 can be observed through the control device 20. Once the temperature is too high, the liquid nitrogen content in the tank is too low. The control device will alarm to notify the transfer personnel Transfer to the nearest biological sample warehouse as soon as possible; if the biological sample is placed at normal temperature for a long time, it will cause damage; when the transportation is completed, the recorded temperature data can be extracted from the control device through the external data line for the experimenter to carry out Analysis.

A preferred further implementation of this embodiment further includes a tank base 21, and the tank 1 is disposed on the tank base 21.

A preferred further implementation of this embodiment further includes a battery 23, which is provided at the bottom of the tank base 21, and the battery 23 is electrically connected to the control device 20; the control device 20 includes a control A circuit board, a display 24, a temperature sensor 25 and an alarm; the temperature sensor 25 senses the temperature in the tank 1, and the temperature sensor 25 is electrically connected to the control circuit board, the control circuit board It is electrically connected to the display 24, which is provided outside the tank 1; the alarm is electrically connected to the control circuit board.

In a preferred further implementation of this embodiment, the can lid 4 includes a can lid body 26 and a sealed foam lid 27, the can lid body 26 is capped on the can body 1, and the can lid body 26 faces the can A sealing foam cover 27 is extended in the body, and the sealing foam cover 27 seals the can body.

It also includes a reinforced outer ring plate 28, a sleeve ring plate 29 and a handle 30; the reinforced outer ring plate 28 is fixed around the outer periphery of the tank 1 and the sleeve ring plate 29 is fixed on the reinforced outer ring plate On the periphery of 28, the handle 30 is disposed on the collar plate 29. The reinforced outer ring plate 28 and the sleeve plate 29 can be used to reinforce the stable structure of the structure, and the handle 30 can be used to facilitate hand-carrying.

A

The order of the above embodiments is only for convenience of description, and does not represent the advantages and disadvantages of the embodiments.

Finally, it should be noted that the above embodiments are only for explaining the technical solutions of the present invention, rather than limiting them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand: The technical solutions described in the foregoing embodiments can still be modified, or some of the technical features can be equivalently replaced; and these modifications or replacements do not deviate from the spirit of the technical solutions of the embodiments of the present invention And scope.

Claims

A deep and low temperature transfer device, characterized by comprising a tank body, an adsorbent material, a holding member and a tank cover;

The adsorbent material is provided in the tank, the holding member is provided above the adsorbent material, and the holding member is provided with a plurality of cooling holes, and the holding member can store a freezing box;

The tank cover is provided on the tank body, and a vacuum cavity layer is formed in the tank wall of the tank body.

2. The cryogenic temperature transfer device according to claim 1, wherein the holding member includes a holding portion and a holding container, the adsorbent material may be located in the holding container, and the freezing box may be A plurality of cooling holes are penetrated between the receiving part and the receiving part.

3. The cryogenic transfer device according to claim 2, characterized in that:

The end face of the adsorbent material is recessed with a base receiving groove;

The holding member includes a holding plate, a holding plate ring, and a holding support ring;

The lower end of the holding plate ring is fixed on the periphery of the circumference of the holding plate, and the holding plate is provided with a plurality of cooling holes in a honeycomb shape, and the holding plate ring is provided with a plurality of circumferential arrays Vertical cooling channel;

A connecting plate ring is extended on the periphery of the upper end circumference of the holding plate ring, and the other end of the connecting plate ring is vertically provided with a holding support ring;

The receiving support ring and the lower end surface of the receiving plate and the receiving plate ring surround a receiving portion; the receiving ring and the upper surface of the receiving plate form a receiving groove as the receiving portion.

4. The cryogenic temperature transfer device according to claim 2, wherein the holding member includes a holding A plate and a holding A support ring, and a circumferential periphery of the holding A plate and the holding A The upper end of the support ring is fixed vertically; the holding plate A is provided with a plurality of cooling holes;

The upper end surface of the A-board is formed into a holding portion; the lower end surface of the A-board is surrounded by the supporting ring of the A-board to form a holding portion.

5. The cryogenic temperature transfer device according to claim 2, wherein a positioning support ring strip is provided in the tank body, and a positioning ball plug is provided on the positioning support ring strip extending into the tank body; the positioning The support ring bar supports the holding member in the tank body.

6. The cryogenic transfer device according to any one of claims 1-5, further comprising a control device that can detect, record, and display the temperature in the tank.

7. The cryogenic temperature transfer device according to claim 6, further comprising a tank base, the tank is disposed on the tank base.

8. The cryogenic temperature transfer device according to claim 6, further comprising a battery, the battery is provided at the bottom of the tank base, and the battery is electrically connected to the control device;

The control device includes a control circuit board, a display, a temperature sensor and an alarm;

The temperature sensor senses the temperature in the tank, and the temperature sensor is electrically connected to the control circuit board, the control circuit board is electrically connected to the display, and the display is provided outside the tank ; The alarm is electrically connected to the control circuit board.

9. The cryogenic temperature transfer device according to claim 1, wherein the tank lid includes a tank lid body and a sealed foam lid, the tank lid body lid is provided on the tank body, and the tank lid The body extends into the tank body with a sealing foam cover, and the sealing foam cover seals the tank body.

10. The cryogenic transfer device according to claim 1, further comprising a reinforced outer ring plate, a collar plate and a handle;

The reinforced outer ring plate ring sleeve is fixed on the periphery of the tank body, the sleeve plate ring sleeve is fixed on the periphery of the reinforced outer ring plate, and the handle is provided on the sleeve plate.