KR101822466B1 - Cryogeric storage vessel - Google Patents

Abstract

The present invention relates to a cryogenic storage vessel using liquefied nitrogen, and more specifically comprises: a folding type scaffolding; a folding type shelf for supporting a rack; and a shelf table, thereby improving convenience. By forming an icing prevention structure on a cover, an icing is prevented at an edge of an entrance of the vessel. A heat reflection portion is formed by using an aluminum vacuum deposition method on an inner side surface of an upper portion of an inner bottle. As such, radiant heat penetrating from the outside is blocked so that an upper portion temperature and a lower portion temperature of the storage vessel can be constantly maintained at the same temperature, and at the same time, heat loss can be reduced.

Description

[0001] Cryogical storage vessel [0002]

The present invention relates to a cryogenic storage container using liquefied nitrogen, and more particularly, to a refrigerator having a cryostat, a foldable shelf for a rack base and a shelf table, And by forming a heat reflecting portion using an aluminum vacuum vapor deposition method on the inner surface of the inner tube, it is possible to block the radiant heat penetrated from the outside, thereby keeping the upper temperature of the storage vessel constant at the same temperature as the lower temperature, To a cryogenic storage container capable of reducing the temperature of the cryogenic storage container.

Cryogenic storage containers using liquefied nitrogen are mainly used for long-term storage of cord blood, human derivatives, sperm, eggs, embryos, stem cells, genetic resources, etc. for the purpose of disease treatment or development of cell therapy.

In general, umbilical cord blood is the umbilical cord blood between mother and fetus, and it is possible to extract white blood cells containing hematopoietic stem cells.

This umbilical cord blood is obtained by cutting the umbilical cord when the baby is born and then collecting umbilical cord blood from the vein in the umbilical cord connected to the placenta. The extracted cord blood is placed in a cryogenic storage container and stored frozen.

However, the conventional cryogenic storage container has the following problems.

First, the width of the outlet formed in the lid is narrow, so that the low-temperature steam due to the vaporization of the liquefied nitrogen is discharged at a high density, causing icing around the inlet.

Second, a heat reflecting plate having an aluminum foil film attached to a plate-shaped stainless steel is formed on the upper part of the inner chamber of the storage container, which complicates the structure and lowers production efficiency.

Third, there is a problem in that a safety accident may occur because a safety device for safely putting a rack for storing a heavy sample into a storage container or taking it out to the outside is not provided, and the rack is taken out from the storage container to the outside At the time, there is no shelf to put the rack that was taken out, and it is inconvenient to work and put the rack right on the floor. There is a problem that the remaining liquid nitrogen in the rack falls on the floor and the flooring is damaged.

Fourth, in the conventional low-temperature storage container, the use of the non-slip tape on the foot plate of the storage container has a problem that the foreign matter is caught between the non-slip tape by long-

Fifth, the existing measuring apparatus for measuring the liquid nitrogen level has a problem in that liquid nitrogen is instantaneously vaporized due to the temperature difference between the liquid nitrogen and the measurer, and vaporized nitrogen is deposited above the actual water level, thereby making it difficult to measure the water level accurately .

On the other hand, the prior art relating to the low-temperature storage container is Korean Patent Registration No. 10-2002-7015908.

The present invention has been conceived to solve the problems of the conventional art as described above, and it is an object of the present invention to provide a folding type footrest, a folding shelf for a rack base and a shelf table, And a heat reflection part using an aluminum vacuum evaporation method is formed on the inner surface of the inner tube to prevent icing and to prevent the radiant heat penetrating from the outside and to keep the upper temperature of the storage container at the same temperature as the lower temperature, The purpose is to provide containers.

According to an aspect of the present invention, there is provided a cryogenic storage container comprising: an inlet formed at the same position of each upper end of an outer cylinder and an inner cylinder, A foldable footrest provided at a lower end of the outer barrel and provided with a plurality of anti-slip protrusions; A rotatable tray formed inside the inner tube and on which a sample storage rack is placed; And a supply line for supplying liquefied nitrogen to the inside of the inner cylinder, wherein the lid includes a discharge unit for discharging nitrogen gas to the outside; And a sponge for preventing external heat from entering the sponge, wherein the sponge is formed of a first sponge and a second sponge, and by forming a preheating portion between the first sponge and the second sponge, Thereby preventing occurrence of icing.

The cryogenic storage container may further include a shelf table formed at an upper end of the outer casing; A shelf folding shelf formed on the right side of the outer cylinder for storing the sample storage rack taken out from the ultra-low temperature storage container; And a safety support formed on both sides of the upper end of the outer tube.

In addition, the tray is divided into a plurality of spaces by a separator, and a label for distinguishing the specimen is attached to the inside of the arcuate handle formed at the upper end of the separator.

The cryogenic storage container may further include a liquid nitrogen level measuring guide pipe for measuring the level of the liquid nitrogen, and the liquid nitrogen level measuring guide pipe is formed with a plurality of holes through which nitrogen gas can escape .

In addition, a heat radiation part is formed on the inner surface of the inner tube by using an aluminum vacuum deposition method, and a heat radiation part for shielding radiant heat penetrated from the outside is formed.

The cryogenic storage container according to the present invention has the following effects.

First, a preheating portion is formed between the first sponge and the second sponge of the lid, so that nitrogen dioxide is discharged after being preheated by the preheating portion, so that icing can be prevented from occurring around the inlet.

Secondly, by forming the exhaust portion of the nitrogen nitride in the cover to be wide, it is possible to prevent nitrogen dioxide from being discharged at a low density and to cause icing around the inlet.

Third, by forming a heat reflection part using aluminum vacuum vapor deposition method on the inner surface of the inner tube, the radiant heat penetrated from the outside is blocked without a separate heat reflecting plate, and the upper temperature of the cryogenic storage container is kept constant at the same temperature as the lower temperature And the heat loss can be reduced at the same time.

Fourth, by forming the safety support table and the shelf table on the upper end of the cryogenic storage vessel outer casing, it is possible to prevent a safety accident when the sample storage rack is put into a cryogenic storage container or taken out to the outside.

In addition, a folding shelf for a rack support which can hold a sample storage rack taken out to the middle part of the cryogenic storage container outer cylinder is formed, thereby enhancing the work efficiency and preventing the bottom material from being damaged.

Further, by using a folding type foot plate in which a plurality of anti-slip projections are formed on a stainless steel material, there is an effect of reducing the phenomenon of foreign matter, facilitating disinfection and cleaning.

Fifth, even when liquefied nitrogen is instantaneously vaporized by a large temperature difference between the liquefied nitrogen level indicator and the liquefied nitrogen when the liquefied nitrogen level measurer contacts the liquefied nitrogen by forming a plurality of holes in the liquefied nitrogen level measuring guide pipe, So that the liquid level of the liquid nitrogen can be accurately measured.

In addition, by attaching a label to the upper part of the separator, it is easy to distinguish the kind of the sample to be stored. By forming the label inside the handle formed on the separating plate, the user's hand And scratching of the body can be prevented.

The effects of the present invention are not limited to the effects mentioned above, and other effects not mentioned can be clearly understood by those skilled in the art from the description of the claims.

1 is a perspective view of a cryogenic storage container according to an embodiment of the present invention.
2 is a front view of a cryogenic storage container according to an embodiment of the present invention.
3 is a plan view showing a folding type scaffold and a foldable shelf for rack support folded in a cryogenic storage container according to an embodiment of the present invention.
FIG. 4 is a plan view showing a folding type scaffold and a foldable shelf for rack support in a cryogenic storage container according to an embodiment of the present invention.
5 is a cross-sectional view of a cryogenic storage vessel according to an embodiment of the present invention.
6 is a view illustrating a structure for preventing icing from occurring in a cryogenic storage container according to an embodiment of the present invention, in comparison with the prior art.
7 is a view showing a structure of a guide pipe for measuring a liquid nitrogen level of a cryogenic storage container according to an embodiment of the present invention, in comparison with the prior art.

Hereinafter, preferred embodiments of the present invention will be described with reference to the accompanying drawings. However, some configurations which are not related to the gist of the present invention may be omitted or compressed, but the configurations omitted are not necessarily those not necessary in the present invention, and they may be combined by a person having ordinary skill in the art to which the present invention belongs. .

FIG. 1 is a perspective view of a cryogenic storage container according to an embodiment of the present invention, FIG. 2 is a front view of a cryogenic storage container according to an embodiment of the present invention, FIG. 3 is a cross- FIG. 4 is a plan view showing a folding type shelf for a folding type footrest and a rack support in an ultra-low temperature storage container according to an embodiment of the present invention, and FIG. 5 is a plan view showing the folding type shelf for a rack support, FIG. 6 is a diagram illustrating a structure for preventing icing in a cryogenic storage container according to an embodiment of the present invention, and FIG. 7 is a cross-sectional view illustrating a cryogenic storage container according to an embodiment of the present invention. And comparing the structure of the guide pipe for measuring the liquid nitrogen level of the container with that of the prior art.

Hereinafter, the configuration of the ultra-low temperature storage container 100 according to the present invention will be described in detail with reference to FIGS. 1 to 7. First, the external configuration of the ultra-low temperature storage container 100 is described first. 7, the internal structure of the ultra-low temperature storage container 100 will be described in detail.

1 to 5, the outer structure of the ultra-low temperature storage container 100 according to the present invention includes an outer tube 110, an inlet 180, a lid 181, a shelf table 170, a liquefied nitrogen supply unit 150, a safety support 140, a controller 160, a folding footrest 130, and a folding shelf 120 for a rack foot.

The inlet 180 through which the sample storage rack 240 is inserted and removed is formed through the outer tube 110 and the inner tube 111 at the same positions of the upper ends of the outer tube 110 and the inner tube 111, A cover 181, which can open and close the inlet 180, is provided to open and close the inlet 180 as needed. A detailed description of the anti-icing structure of the cover 181 will be given later.

The shelf table 170 is formed at the upper end of the outer cylinder 110 of the cryogenic storage container 100 and can be used to store protective equipment and related documents during operation and to store the new sample storage rack 240 in a cryogenic storage container The new sample storage rack 240 is placed on the shelf table 170 and then the sample storage rack 240 which has been stored is taken out and placed on the folding shelf 120 for rack support The new sample storage rack 240 placed on the shelf table 170 is put into the ultra-low temperature storage container 100, so that the efficiency of the operation can be improved.

The liquefied nitrogen supply unit 150 is connected to the supply line 152 to supply liquefied nitrogen through the supply line 152 between the lower end inner surface of the inner cylinder 111 of the cryogenic storage container 100 and the lower end surface of the tray 223 Supply. The liquid nitrogen supply unit 150 is provided with a dual valve, so that even when one valve fails, the other valve is activated to supply the liquefied nitrogen, thereby preventing the operation from being interrupted.

The safety support rods 140 are formed on both sides of the upper end of the outer cylinder 110 of the cryogenic storage container 100. When the sample storage racks 240 are inserted into the cryogenic storage container 100, It is possible to work in a state in which the safety support member 140 is held by using a hand that does not hold the support member 240, thereby preventing a safety accident, and it is possible to stably insert or remove the sample storage rack 240 . At this time, since the operator may be right-handed or left-handed, two of the safety supports 140 are formed on both sides of the upper end of the outer cylinder 110 of the ultra-low temperature storage container 100.

The controller 160 is disposed at the upper end of the outer cylinder 110 of the cryogenic storage container 100 and includes a display for displaying operating conditions of the cryogenic storage container 100 such as upper and lower temperature display, And input means for operating various functions are provided.

The folding scaffold 130 is formed by folding the sample storage rack 240 at the lower end of the outer cylinder 110 of the cryogenic storage container 100 so that the sample storage rack 240 can be easily inserted into or removed from the cryogenic storage container 100, A plurality of non-slip protrusions 131 are formed, so that the phenomenon of foreign matter is reduced, and disinfection and cleaning are easy. At this time, when the folding footrest 130 is not used, it is possible to utilize the space efficiently by folding the folding footrest 130. [

The folding shelf 120 for rack support is formed at the middle portion on the right side of the outer cylinder 110 of the cryogenic storage container 100 and does not lay the sample storage rack 240 taken out from the cryogenic storage container 100 directly on the floor, By placing the heavy sample storage rack 240 on the folding shelf 120 for rack support, it is possible to store the heavy sample storage rack 240 on the folding shelf 120 for the rack support without having to bend the waist down on the floor at once, . In addition, when the sample storage rack 240 taken out from the ultra-low temperature storage container 100 is directly placed on the floor, the flooring material may be damaged by the residual liquid nitrogen remaining in the sample storage rack 240. This can be prevented by storing it in the folding shelf 120.

Hereinafter, the internal structure of the ultra-low temperature storage container 100 according to the present invention will be described in detail with reference to FIG. 5 to FIG.

5, the internal structure of the ultra-low temperature storage container 100 according to the present invention includes an inner tube 111, a tray 223, a separator 220, a supply line 152, a heat reflecting portion 250, And a liquid nitrogen level measurement guide pipe 230.

A vacuum layer is formed in a space between the inner passage 111 and the outer cylinder 110. A heat reflecting portion 250 formed by using an aluminum vacuum deposition method is formed on the inner surface of the upper portion of the inner cylinder 111, It is possible to block radiated heat to keep the upper temperature of the cryogenic storage container 100 constant at the same temperature as the lower temperature. In addition, since the heat reflecting portion 250 is formed by using the aluminum vacuum deposition method, it is not necessary to mount a separate heat reflecting plate, and the structure of the ultra-low temperature storage container 100 can be simplified.

It is also possible to improve the vacuum performance and the heat shielding performance by coating a glass film on the outer surface of the inner cylinder 111 formed with the vacuum layer and the inner surface of the outer cylinder 110 by coating the same with a glass material.

The tray 223 is installed inside the inner tube 111 and is made of aluminum and is stored in the sample storage rack 240. The tray 223 is rotatably coupled to the rotation shaft 211 rotatably coupled to the central support shaft 210, And is manually rotated about the support shaft 210.

The tray 223 is divided into a plurality of spaces by the separator 220 to store a plurality of sample storage racks 240.

An arcuate knob 221 is formed on the upper end of the separator 220 so that the tray 223 can be manually rotated through the handle 221 and the arcuate knob 221 A label 222 for distinguishing the stored sample is attached. The label 222 is formed on the inside of the arcuate grip 221 so that the user's hand or the body can be prevented from being scratched by the label 222 when the sample storage rack 240 is moved in and out.

The supply line 152 is a tube for supplying liquefied nitrogen to the inner cylinder 111 and is installed to pass through a lower portion of the inner cylinder 111 through a vacuum layer formed between the outer cylinder 110 and the inner cylinder 111. The supply line 152 supplies the liquid nitrogen to the space between the lower end surface of the tray 223 inside the inner cylinder 111 and the lower end inner surface of the inner cylinder 111.

The liquefied nitrogen level measuring guide pipe 230 is configured to guide the liquefied nitrogen liquid level measuring instrument 232 to vertically contact the inner surface of the lower end of the inner cylinder 111 to accurately measure the level of the liquefied nitrogen, A plurality of holes 231 are formed in the water level measurement guide pipe 230.

As shown in Fig. 7 (a), conventionally, no holes are formed in the liquid nitrogen level measurement guide pipe 230a for discharging nitrogen gas to the outside.

Therefore, when the liquid nitrogen level indicator 232a is supplied to the liquefied nitrogen through the liquefied nitrogen level measuring guide pipe 230a to measure the level of the liquefied nitrogen, the temperature difference between the liquefied nitrogen level indicator 230 and the liquefied nitrogen The nitrogen gas is not allowed to escape to the outside and is soaked in the liquefied nitrogen level measuring guide pipe 230a so as to be immersed in the liquefied nitrogen of the liquefied nitrogen liquid level indicator 232a So that the level of the liquid nitrogen could not be accurately measured.

7 (b), nitrogen gas is supplied to the outside of the liquid nitrogen level measuring guide pipe 230 through the plurality of holes 231 formed in the liquid nitrogen level measuring guide pipe 230 It is possible to accurately measure the level of the liquefied nitrogen because the vaporized nitrogen does not get buried in the liquid nitrogen level indicator 232.

That is, in the liquid nitrogen level measurer 232, the portion immersed in the ultra-low temperature liquefied nitrogen is relatively low in temperature, causing icing, and measuring the level with the generated icing height. At this time, unless nitrogen is discharged to the outside of the liquid nitrogen level determination guide pipe 230, it is difficult to accurately measure the level of the liquid nitrogen because ice is formed to a point higher than the actual liquid nitrogen level by the nitrogen gas.

Therefore, in the present invention, a plurality of holes 231 are formed in the liquid nitrogen level measuring guide pipe 230 so that the nitrogen oxide does not stay inside the liquid nitrogen level measuring guide pipe 230 and the plurality of holes 231 So that ice can be formed only up to the level of the actual liquid nitrogen, so that the level of the liquid nitrogen can be accurately measured.

The cover 181 of the ultra-low temperature storage container 100 according to the present invention is provided with a cutout portion 186 and a discharge portion 182 for discharging nitrogen gas to the outside, And the sponge 183 and 185 are formed to prevent the water from flowing into the cryogenic storage container 100 through the cutout 186. [

The sponge is composed of a first sponge 183 formed in the middle and a second sponge 185 formed in the outermost periphery and a preheating unit 184 is formed between the first sponge 183 and the second sponge 185 .

As shown in FIG. 6 (a), since the first sponge 183a and the second sponge 185a are formed in close contact with each other and there is no separate preheating unit (not shown) There is a problem that icing is generated around the inlet by being discharged to the discharge portion 182a through the cutout portion 186a.

7 (b), the preheating unit 184 is provided between the first sponge 183 and the second sponge 185, so that nitrogen monoxide is preheated in the preheating unit 184 The temperature of the nitrogen gas is increased to prevent the icing from occurring around the inlet 180. In this case,

6 (a), when the width of the discharging portion 182a is narrow, when the lid 181 is opened for loading or unloading the sample storage rack 240, The liquefied nitrogen is vaporized by a large temperature difference in the internal combustion engine 100, so that high-density nitrogen gas is discharged through the discharge portion 182a, causing icing around the inlet 180. [ 6 (b), the width of the discharge portion 182 of the lid 181 is enlarged to a size corresponding to the width of the second sponge 185, and the inlet 180 It is possible to prevent nitrogen dioxide from being discharged at a low density and to prevent icing from occurring around the inlet 180.

As described in detail above, the cryogenic storage container 100 according to the present invention has the preheating portion 184 formed between the first sponge 183 and the second sponge 185 of the lid 181, Since it is discharged after being preheated by the preheating section 184, it is possible to prevent icing from occurring around the inlet 180.

Further, by forming the exhaust portion 182 of nitrogen nitride in the lid 181 widely, it is possible to prevent nitrogen dioxide from being discharged at a low density and causing icing around the inlet 180.

In addition, a heat reflecting portion 250 using an aluminum vacuum deposition method is formed on the inner surface of the inner tube 111, and the radiant heat penetrated from the outside is blocked without a separate heat reflecting plate, The heat loss can be reduced while maintaining the same constant temperature as the lower temperature.

By forming the safety support table 140 and the shelf table 170 on the upper end of the cryogenic storage container 100 of the ultra-low temperature storage container 100, when the sample storage rack 240 is put into the ultra-low temperature storage container 100 or taken out to the outside , It is possible to prevent a safety accident.

In addition, a folding shelf 120 for a rack support, on which a sample storage rack 240 carried on the middle part of the outer cylinder 110 of the ultra-low temperature storage container 100 is placed, can improve the efficiency of the work, There is an effect that can be prevented.

The use of the foldable footrest 130 in which a plurality of anti-slip projections 131 are formed on the stainless steel material reduces the effect of foreign matter, facilitates disinfection and cleaning.

A plurality of holes 231 are formed in the liquid nitrogen level measurement guide pipe 230 so that when the liquid nitrogen level indicator 232 contacts the liquefied nitrogen, Even if liquefied nitrogen vaporizes instantaneously due to the vaporization of the liquefied nitrogen, the vaporized nitrogen flows out through the holes 231, so that the liquid level of the liquefied nitrogen can be accurately measured.

In addition, the label 222 is attached to the upper part of the separating plate 220, so that it is easy to distinguish the kind of the sample to be stored. When the label 222 is inserted into the arcuate handle 221 formed on the separating plate 220, It is possible to prevent the user's hand or the body from being scratched by the label 222 when the sample storage rack 240 is moved in and out.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, And additions should be considered as falling within the scope of the claims of the present invention.

100: Cryogenic storage container
110: outer tube
111: My heart
120: Folding shelf for rack base
130: Folding footrest
131: Non-slip projection
140: Safety support
150: Liquefied nitrogen supplier
152: supply line
160: Controller
170: shelf table
180: Entrance
181: Cover
182:
183: First sponge
184:
185: Second sponge
186:
210: Support shaft
211:
220: separator plate
221: Handle
222: Label
223: Tray
230: Liquid nitrogen level measuring guide
231: hole
232: Liquid nitrogen level measurer
240: Sample storage rack
250:

Claims (5)

An inlet formed at the same position of each upper end of the outer tube and the inner tube, the tube being provided with a lid;
A foldable footrest provided at a lower end of the outer barrel and provided with a plurality of anti-slip protrusions;
A shelf table formed at an upper end of the outer tube;
A folding shelf for a rack support which is formed on the right side of the outer cylinder and stores the sample storage rack taken out;
A safety support formed on both sides of the outer cylinder top;
A rotatable tray formed in the inner tube and on which the sample storage rack is placed;
A supply line for supplying liquefied nitrogen into the inner cylinder; And
And a liquid nitrogen level measurement guide pipe for measuring the liquid nitrogen level,
The tray is divided into a plurality of spaces by a separator,
A label for distinguishing the sample is attached to the inside of the arcuate handle formed on the upper end of the separator,
In the cover,
A discharge portion for discharging nitrogen nitride to the outside; And
A sponge for preventing external heat from entering,
The width of the discharge portion is enlarged to a size corresponding to the width of the second sponge so that the interval between the outlet and the inlet is increased so that nitrogen dioxide is discharged at a low density to prevent icing from occurring around the inlet,
Wherein the sponge comprises a first sponge formed in the middle and a second sponge formed in the outermost periphery,
A preheating portion is formed between the first sponge and the second sponge so that nitrogen dioxide is preheated in the preheater and then discharged to the outlet so that the temperature of the nitrogen gas is increased to prevent icing from occurring around the inlet,
The liquid nitrogen level measuring guide pipe is provided with a plurality of holes through which nitrogen nitrogen can escape so that the nitrogen nitrogen is discharged to the outside of the liquid nitrogen level measuring guide pipe through the plurality of holes, The liquid level of the liquid nitrogen can be accurately measured,
And a heat reflecting portion formed on the inner surface of the inner tube by using an aluminum vacuum vapor deposition method to block radiant heat penetrated from the outside. delete delete delete delete

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