WO2020051914A1 - 一种退热贴及其制备方法 - Google Patents

一种退热贴及其制备方法 Download PDF

Info

Publication number
WO2020051914A1
WO2020051914A1 PCT/CN2018/105837 CN2018105837W WO2020051914A1 WO 2020051914 A1 WO2020051914 A1 WO 2020051914A1 CN 2018105837 W CN2018105837 W CN 2018105837W WO 2020051914 A1 WO2020051914 A1 WO 2020051914A1
Authority
WO
WIPO (PCT)
Prior art keywords
layer
antipyretic
parts
film layer
thermochromic
Prior art date
Application number
PCT/CN2018/105837
Other languages
English (en)
French (fr)
Inventor
陈绍永
Original Assignee
湖南新金辐医疗科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 湖南新金辐医疗科技有限公司 filed Critical 湖南新金辐医疗科技有限公司
Priority to PCT/CN2018/105837 priority Critical patent/WO2020051914A1/zh
Publication of WO2020051914A1 publication Critical patent/WO2020051914A1/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18—Manufacture of films or sheets
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/05—Alcohols; Metal alcoholates
    • C08K5/053—Polyhydroxylic alcohols
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/07—Aldehydes; Ketones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L29/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers
    • C08L29/02—Homopolymers or copolymers of unsaturated alcohols
    • C08L29/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids

Definitions

  • the invention relates to the field of medical products, in particular to an antipyretic patch and a preparation method thereof.
  • thermometers to measure the temperature and reduce fever. , Not only troublesome but also affect the rest of infants.
  • the patent No. CN202821792U proposed that the polymer hydrogel layer of the antipyretic paste be added with a material that can change color with temperature changes, so that the caregiver can clearly Changes in the patient's condition were observed. Because the non-woven fabric of the outer layer of the heat-repellent paste covers the hydrogel layer, the discoloration in the hydrogel layer is difficult or impossible to observe. At the same time, adding discoloring materials directly to the hydrogel layer not only increases the complexity of the process, but also because infants and young children have delicate skin, direct contact with discoloring materials can easily lead to allergies and other phenomena. For this reason, it is necessary to develop an antipyretic patch that is easy to observe and not easily cause human allergies.
  • the object of the present invention is to provide an antipyretic patch, which has a good antipyretic effect, and at the same time it is also convenient for parents to judge the body temperature of infants and young children through the change of the thermochromic layer.
  • the production method is relatively simple and suitable for large Specifications for production.
  • An antipyretic paste includes an antipyretic gel layer, a thermochromic layer, and a protective layer in order from the inside to the outside.
  • the protective layer is a transparent film layer, and the edges of the protective layer are directly bonded to the antipyretic gel layer. Together, and the thermochromic layer is located in the middle of the protective layer and the antipyretic gel layer;
  • the film layer includes 65 to 85 parts by weight of polyvinyl alcohol, 4 to 6 parts of glutaraldehyde, 8 to 11 parts of glycerol, 3 to 5 parts of sodium hydroxide, 5.4 to 6.5 parts of carboxamide, and chlorination. 3 to 5 parts of calcium, 4 to 6 parts of coral powder, 10 to 14 parts of 2-acrylamide-2-methylpropanesulfonic acid, 2 to 4 parts of anionic surfactants, and 45 to 55 parts of water;
  • the antipyretic gel layer includes, by mass, 30 to 40 parts of acryloylmorpholine, 8 to 10 parts of 2-acrylamide-2-methylpropanesulfonic acid, 2 to 4 parts of sodium hydroxide, and 7 to 9 glycerol. Parts, bridging agent KE-301 ⁇ 2 parts, cyclohexanone peroxide 0.5 ⁇ 1.5 parts, cross-linking agent DCP 1 ⁇ 2 parts.
  • the temperature-sensitive color-developing mechanism of the temperature-sensitive color-changing layer will take effect, and the preset pattern will be displayed.
  • the thin film layer is transparent, so it is easy to remind the observer to pay close attention to the patient's temperature.
  • the main function of the film layer is to combine the thermochromic layer and the antipyretic gel layer into a complete product, which plays a role of basic mechanical dependence.
  • the film layer due to the hydrophilic nature of the PVA series of substances, when the body temperature rises, the body surface sweat exudates, and when the sweat reaches the film layer through the antipyretic gel layer, the film layer will absorb this part of the sweat.
  • polyvinyl alcohol is a main film-forming agent
  • glycerin is a plasticizer of polyvinyl alcohol.
  • the hydroxide of sodium hydroxide and the hydroxyl group of polyvinyl alcohol produce hydroxyl groups with electrolytes.
  • the addition of sodium hydroxide prevents the polyvinyl alcohol from cross-linking with glutaraldehyde.
  • 2-acrylamide-2-methylpropanesulfonic acid Since 2-acrylamide-2-methylpropanesulfonic acid is a strong acid, the above solution will be adjusted to be acidic.
  • polyvinyl alcohol and glutaraldehyde will be cross-linked to form polyvinyl glutaraldehyde, forming a three-dimensional network. This structure further improves the mechanical properties and heat resistance of the thin film layer.
  • Tm ⁇ H / ⁇ S
  • Tm the polymer melting point
  • ⁇ S the entropy change of the polymer during the melting process.
  • the factors that affect ⁇ H and ⁇ S can affect the melting point of the polymer. Among them, intermolecular forces affect ⁇ H, and the rigidity and flexibility of molecular chains affect ⁇ S.
  • glycerin swells and dilutes the polyvinyl alcohol, reduces the intermolecular force of the polyvinyl alcohol, and reduces the melting temperature of the polyvinyl alcohol composition.
  • the main component of coral powder is calcium carbonate, which helps to accelerate the film formation efficiency of the thin film layer.
  • the anionic surfactant can promote sufficient mixing between materials.
  • the antipyretic gel layer and the film layer both contain 2-acrylamide-2-methylpropanesulfonic acid and sodium hydroxide
  • the antipyretic gel layer when the antipyretic gel layer is coated on the thermochromic layer and the thin film layer, the 2-acrylamide-2-methylpropanesulfonic acid and sodium hydroxide on the antipyretic gel layer and the film layer can promote the fusion of the two independent layers, which weakens the interface between the layers. It is beneficial to improve the integrity of the antipyretic paste, which will also help to ensure the quality of the antipyretic paste.
  • the film layer has a plurality of holes.
  • the opening of the pores is convenient for the patient's body temperature to be lost through the pores as soon as possible, thereby also helping to speed up the decline of the patient's body temperature.
  • the anionic surfactant is sodium dodecylbenzenesulfonate.
  • sodium dodecylbenzenesulfonate can not only promote sufficient mixing between materials.
  • sodium dodecylbenzene sulfonate has a synergistic effect with carboxamide and has good insect resistance.
  • the carboxamide and sodium dodecylbenzenesulfonate in the film layer will be sucked into the body by the insect.
  • the carboxamide will damage the chitin of the insect body wall.
  • sodium dodecylbenzenesulfonate will dissolve the waxy layer of the body wall and attach to it to form a water-impermeable and air-impermeable film, so that insect stomata will be blocked and suffocated to death, which will improve Insect resistance of the film layer.
  • the coral powder is made from coral treated with an enzyme solution containing alkaline protease, papain and trypsin.
  • chitin is decomposed and produced in the corals treated by the enzyme solution, which not only has strong viscosity, but can improve the bonding strength of various substances in the film layer. At the same time, chitin is still a good inhibitor. Bactericide, which can effectively improve the antibacterial performance of the film layer, thereby helping to extend the storage life of the antipyretic paste.
  • thermochromic layer is a mixture of dihydroindole and polyurethane, and the mass ratio of the dihydroindole and polyurethane is 1: 3.
  • the indole has a good color changing effect, and the indole and polyurethane are mixed and then coated on the film layer.
  • the thermochromic layer and the film layer The bonding effect between them is effectively enhanced, thereby facilitating the improvement of the quality of the antipyretic paste.
  • the surface of the antipyretic gel layer is provided with several protrusions.
  • the protrusion when the antipyretic patch is applied to the forehead of the patient, the protrusion will squeeze the patient's forehead, thereby helping to expand the pores of the patient's forehead, which will also help to speed up the fever reduction of the patient.
  • a method for preparing an antipyretic paste includes the following steps:
  • Step 1 first apply a thermochromic layer on the film layer, and then place the thermochromic layer in a drying box to dry the thermochromic layer;
  • Step 2 Apply an antipyretic gel layer on the thermochromic layer and the thin film layer, and then cure by placing it under the condition of UV light again, so as to obtain an initial product of antipyretic paste.
  • thermosensitive color-changing layer is applied in step 1, the edges of the film layer are folded to cover the sides of the thermochromic layer.
  • the thin film layer and the antipyretic gel layer together seal the thermochromic layer, thereby preventing the thermochromic layer from contacting the human body and causing damage to the skin.
  • the present invention has the following beneficial effects:
  • thermochromic layer which is beneficial to the attention of the observer to the patient
  • the film layer is provided with pores, which can help patients to reduce fever as soon as possible;
  • the film layer of the present invention also has good antibacterial and insecticidal effects
  • the formula of the antipyretic gel layer and the film layer both have 2-acrylamide-2-methylpropanesulfonic acid and sodium hydroxide, which helps the two layers to fuse with each other, thereby achieving integrity.
  • FIG. 1 is a schematic structural diagram of an antipyretic paste
  • FIG. 2 is a schematic structural diagram of a thin film layer
  • FIG. 3 is a flowchart of a preparation process of the antipyretic paste.
  • an antipyretic gel layer 11, a protrusion; 2, a thermochromic layer; 3, a thin film layer; 31, a pore.
  • An antipyretic sticker as shown in FIG. 1 and FIG. 2, is an antipyretic gel layer 1, a thermochromic layer 2 and a protective layer in order from the inside to the outside, wherein the protective layer is a transparent thin film layer 3, and The heat dissipation effect can be improved.
  • the surface of the thin film layer 3 is also provided with a plurality of apertures 31, which is conducive to the heat generated by the human body being dissipated from the apertures 31.
  • the thermochromic layer 2 is a mixture of the color-changing material indoline and polyurethane at a mass ratio of 1: 3, which helps the thermochromic layer 2 and the thin film layer 3 and the antipyretic gel layer 1 to proceed. Bonds effectively.
  • the temperature-sensitive color-developing mechanism of the temperature-sensitive color-changing layer 2 will function, and the preset pattern will be displayed.
  • the thin film layer 3 is transparent, so it is convenient to remind the observer to pay close attention to the patient's body temperature.
  • the surface of the antipyretic gel layer 1 facing away from the film layer 3 is provided with a plurality of protrusions 11, and the surface of the protrusion 11 is spherical, so that when the antipyretic paste fits on the forehead of the patient, the protrusion 11 The forehead will be squeezed so that the skin is stretched, which is conducive to the opening of the pores, which will also improve the heat dissipation of the patient.
  • the film layer can also be made of polyvinyl alcohol, polyurethane, thermoplastic polyurethane, aramid, cellulose acetate, cellulose triacetate, cyanocellulose, nylon, polypropylene, polyvinylidene fluoride, polypropylene, poly Sulfone, polyethersulfone, polytetrafluoroethylene, polyester, polycarbonate, polysulfoneamide, polyetherketone, sulfonated polysulfone, perchloroethylene, polystyrene, polyphenylene ether, polyimide, silicone rubber, Polyether, polyetheramide, polyfuran alcohol, sulfonated polyethersulfone, polyethylene, polyvinyl chloride, or any of several main materials.
  • the film layer can also be added with non-toxic plasticizers, cross-linking agents, initiators, monomers with double bonds, pH adjusters, fillers, dyes, preservatives and some other auxiliaries.
  • a method for preparing an antipyretic paste, as shown in FIG. 3, includes the following steps:
  • thermochromic layer 2 First apply the same thermochromic layer 2 on the thin film layer 3 as in Example 1, and fold the edge of the thin film layer 3 in the direction of the thermochromic layer 2 and cover the sides of the thermochromic layer 2, Then put it in a drying box at 70 ° C to dry the thermochromic layer 2;
  • thermochromic layer 2 Apply an antipyretic gel on the dried thermochromic layer 2 and the edge of the surface of the thin film layer with the thermochromic layer 2 to form an antipyretic gel layer 1 and heat coagulate
  • the side of the adhesive layer 1 facing away from the thermochromic layer 2 is pressed to protrude 11 and then cured under UV light with a strength of 600 MJ / cm 2 and a temperature of 50 ° C., so as to obtain an initial product of antipyretic paste;
  • the preparation method of coral powder first prepare 50ml sodium sulfite buffer solution with pH 8.0, use 1ml triton as a surfactant, and use alkaline protease, papain and trypsin with a mass ratio of 1: 1. 5g combined enzyme is used for catalysis; sodium sulfite buffer solution, triton and combined enzyme are mixed to obtain enzyme solution; coral is immersed in the enzyme solution, the temperature of the constant temperature shaker is controlled at 50 ° C, and the hydrolysis speed is 300r / min. 2 Hours; after that, the corals were ground to coral powder with an average particle size of 10 ⁇ m.
  • the preparation of a sodium sulfite buffer solution is the prior art and is not the core content of this application, so it will not be developed in detail here.
  • the selected anionic surfactant in this embodiment is sodium dodecylbenzenesulfonate.
  • Antibacterial test two drops of cell culture solution were dropped on the film layer 3 of the antipyretic paste. , Then place it in an environment of 25 ° C for three days, and observe the bacterial colonies on the surface (unit: cfu);
  • Insecticidal test The film layer 3 of the antipyretic paste is placed in a space with an average insect density of 10 animals / m 3 facing up, and the insect density in the environment is observed after 24 hours (unit: only / m 3 );
  • Antipyretic aging use test on 100 patients with fever caused by a common cold, and calculate the average time required for each patient to lose fever (unit: h);
  • Peel strength Use a dynamometer to fix the edge of the antipyretic paste, and then pull the dynamometer to observe the dynamometer reading when the antipyretic paste is torn off.
  • the antipyretic paste of the present application has a good antipyretic effect.
  • the film layer 3 also contains coral powder, carboxamide and sodium dodecylbenzenesulfonate, and the addition of coral powder effectively
  • the antibacterial performance of the antipyretic paste of the present application is enhanced, and the synergistic effect of the carbonamide and sodium dodecylbenzenesulfonate makes the antipyretic paste of the present application have a good insecticidal function, so it is suitable for large-scale popularization and use.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Thermal Sciences (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)

Abstract

一种退热贴，其自内向外依次包括退热凝胶层、感温变色层和保护层，该保护层为薄膜层，该保护层与退热凝胶层直接粘合在一起。该薄膜层包含聚乙烯醇、戊二醛、甘油、氢氧化钠、碳酰胺、氯化钙、珊瑚粉、2-丙烯酰胺-2-甲基丙磺酸、阴离子表面活性剂和水；该退热凝胶层包括丙烯酰吗啉、2-丙烯酰胺-2-甲基丙磺酸、氢氧化钠、甘油、架桥剂KE-30、过氧化环己酮和交联剂DCP。

Description

一种退热贴及其制备方法 技术领域
本发明涉及医疗产品领域，特别涉及一种退热贴及其制备方法。
背景技术
当人体出现感冒、伤风、发炎时，很多时候身体就会出现发烧等病症表现。而以往为了能够加快退烧的速度，人们都会选择服用药物来进行治疗。但是，药物在作用人体的时候，往往也会给人体带来不同程度的副作用。尤其对于婴幼儿而言，他们原本身体就还未发育完全，因而一旦长期大量服用退烧药物之后，往往就会产生其他身体方面的病变，从而对于婴幼儿之后的成长发育是非常不利的。
另外，由于婴幼儿发烧退热时，婴幼儿对于自身的身体感应不像成年人一样会自身评价和交流，所以在降温退烧时家长为了随时掌握婴幼儿退烧情况，只能用频繁用体温计进行测量，不仅麻烦而且影响婴幼儿休息。
为了解决上述问题，医疗行业中已提出了相关的专利，如专利号为CN202821792U的专利提出将退热贴的高分子水凝胶层添加可随温度变化而变色的材料，使看护人员能够清楚的观察到患者的病情变化。由于退热贴外层的无纺布遮盖了水凝胶层，导致在水凝胶层的变色不易或无法观察。同时，直接在水凝胶层添加变色的材料，不但增加工艺的复杂性，而且由于婴幼儿皮肤娇嫩，直接接触变色材料容易导致过敏等现象。为此，有必要研发出一种便于观察且不易导致人体过敏的退热贴。
发明内容
本发明的目的是提供一种退热贴，其具有良好的退热效果，同时其也便于家长通过感温变色层的变化来判断婴幼儿的体温情况，另外，其生产方法也较为简便适合大规格进行生产。
本发明的上述技术目的是通过以下技术方案得以实现的：
一种退热贴，自内向外依次包括退热凝胶层、感温变色层和保护层，所述保护层为透明的薄膜层，所述保护层的边缘与退热凝胶层直接粘合在一起，而感温变色层位于保护层和退热凝胶层的中间处；
所述薄膜层按重量份数计，包括聚乙烯醇65～85份、戊二醛4～6份、甘油8～11份、氢氧化钠3～5份、碳酰胺5.4～6.5份、氯化钙3～5份、珊瑚粉4～6份、2-丙烯酰胺-2-甲基丙磺酸10～14份、阴离子表面活性剂2～4份和水45～55份；
所述退热凝胶层按质量计，包括丙烯酰吗啉30～40份、2-丙烯酰胺-2-甲基丙磺酸8～10份、 氢氧化钠2～4份、甘油7～9份、架桥剂KE-301～2份、过氧化环己酮0.5～1.5份、交联剂DCP 1～2份。
通过采用上述技术方案，当人体温度升高后，退热凝胶层因为温度大大低于体温，能提到体温调节作用，降低人体体温，从而保护生命体。
其次，当人体温度超过38.5度以后，感温变色层的感温显色机制就会发生作用，将预设的图案显现出来。加之薄膜层是透明的，因而便于提醒观察者对患者体温进行密切关注。
另外，薄膜层的主要作用为将感温变色层和退热凝胶层组合成一个完整的产品，起到基础力学依附的作用。同时，由于PVA系列物质的亲水性质，当人体体温升高后，体表汗液渗出，汗液透过退热凝胶层抵达薄膜层时，薄膜层将会吸收此部分汗液。
再者，此处聚乙烯醇为主要成膜剂，甘油为聚乙烯醇的增塑剂。而氢氧化钠的氢氧根与聚乙烯醇的羟基生产带有电解质的羟基；另外，由于氢氧化钠的添加，使得聚乙烯醇不会与戊二醛交联，待搅拌均匀后，再加2-丙烯酰胺-2-甲基丙磺酸。由于2-丙烯酰胺-2-甲基丙磺酸是强酸，上述溶液则会被调至酸性，此时聚乙烯醇与戊二醛就会交联成聚乙烯醇缩戊二醛，形成三维网状结构，进而提高了薄膜层的机械性能、耐热性。
由于高聚物的熔点在其熔融过程中热焓和熵变有直接的关系，熔点与热焓和熵变的关系为：Tm＝ΔH/ΔS，式中，Tm为高聚物熔点，ΔH为高聚物在熔融过程的热焓变化，ΔS为高聚物在熔融过程的熵变。影响ΔH、ΔS的因素，能影响到高聚物的熔点。其中分子间作用力影响ΔH，分子链的刚柔性影响ΔS。分子间作用力越大，熔融时需要克服的分子束缚力越大，高聚物的熔点就越高。因此，在聚乙烯醇组合物原料内加入碳酰胺，碳酰胺分散在聚乙烯醇组合物原料混合物内，减小聚乙烯醇分子间的作用力，显著降低聚乙烯醇组合物的熔点。氯化钙也起到降低聚乙烯醇组合物熔融温度的作用。
同时，甘油使聚乙烯醇发生溶胀、稀释，减小聚乙烯醇分子间作用力，起到降低聚乙烯醇组合物熔融温度的作用。
再者，珊瑚粉的主要成份为碳酸钙，其有助于加快薄膜层的成膜效率。而阴离子表面活性剂能够促进各物料之间充分地进行充分混合。
另外，由于退热凝胶层和薄膜层中都含有2-丙烯酰胺-2-甲基丙磺酸和氢氧化钠，因而当退热凝胶层涂布在感温变色层和薄膜层上，退热凝胶层和薄膜层上的2-丙烯酰胺-2-甲基丙磺酸和氢氧化钠能够促进原本独立的两个层相互进行融合，这样减弱了层与层之间的界面，有利于提高退热贴的整体性，这样也有利于保证退热贴的质量。
优选为，所述薄膜层层上开有若干孔隙。
通过采用上述技术方案，孔隙的开设，便于患者体温能够尽快通过孔隙散失掉，从而 也有助于加快患者体温的下降速度。
优选为，所述阴离子表面活性剂为十二烷基苯磺酸钠。
通过采用上述技术方案，十二烷基苯磺酸钠不仅能够促进各物料之间进行充分混合。同时，十二烷基苯磺酸钠与碳酰胺具有协同作用，具有良好的抗虫害的能力。这个过程中，当昆虫在啃咬薄膜层的时候，薄膜层中的碳酰胺和十二烷基苯磺酸钠会被虫子吸入到体内，这时，碳酰胺就会破坏昆虫体壁几丁质，而十二烷基苯磺酸钠会将体壁蜡质层溶解，并附着在上面形成不透水和不透气的一层膜，从而也就能够使昆虫气孔堵塞并窒息死亡，这样也就提高了薄膜层的抗虫性能。
优选为，所述珊瑚粉由经过含有碱性蛋白酶、木瓜蛋白酶和胰蛋白酶的酶液处理的珊瑚制得。
通过采用上述技术方案，经过上述酶液处理后的珊瑚中会分解产生出甲壳素，其不仅具有较强的粘性，能够提高薄膜层内各物质的粘合强度，同时，甲壳素还是良好的抑菌剂，其能够有效地提高薄膜层的抗菌性能，从而有助于延长退热贴的存储时效。
优选为，所述感温变色层为二氢吲哚和聚氨酯的混合物，所述二氢吲哚和聚氨酯的质量比为1：3。
通过采用上述技术方案，首先二氢吲哚具有良好的变色效果，而将二氢吲哚和聚氨酯混合后再涂布于薄膜层上，这样在聚氨酯的作用下，感温变色层与薄膜层之间的粘合效果得到了有效地增强，从而也就便于提高退热贴的质量。
优选为，退热凝胶层的表面带有若干凸起。
通过采用上述技术方案，当退热贴贴在患者的额头时，凸起就会挤压患者的额头，从而有助于扩大患者额头的毛孔，这样也就有利于加快患者的退烧速度。
一种退热贴的制备方法，包括以下步骤：
步骤一、在薄膜层上先涂布上感温变色层，之后置于干燥箱中对感温变色层进行干燥；
步骤二、在感温变色层和薄膜层上涂覆退热凝胶层，再次置于UV光条件下固化，从而得到退热贴初成品。
通过采用上述技术方案，不仅加工效率高，同时，退热凝胶层在UV光的作用下发生固化时，薄膜层内未反应的单体还会与退热凝胶层内带有羧基、氨基或羟基等的物质形成氢键作用力，从而也就加强了薄膜层、感温变色层和退热凝胶层三者之间结合度。
优选为，步骤一中待感温变色层涂覆之后，将薄膜层的边缘翻折包住感温变色层的侧面中。
通过采用上述技术方案，这样薄膜层和退热凝胶层一起将感温变色层封闭起来，避免 感温变色层接触到人体，而对皮肤造成伤害。
综上所述，本发明具有以下有益效果：
1、利用薄膜层替换传统的无纺布，这样便于观察感温变色层的变色，从而有利于观察者对患者的关注；
2、薄膜层上开设有孔隙，这样能够有利于患者尽快退热；
3、本发明的薄膜层还具有良好的抑菌和杀虫效果；
4、退热凝胶层和薄膜层的配方中均有2-丙烯酰胺-2-甲基丙磺酸和氢氧化钠，这样有助于两层之间进行相互融合，从而实现整体性。
附图说明
图1为退热贴的结构示意图；
图2为薄膜层的结构示意图；
图3为退热贴的制备工艺流程图。
图中，1、退热凝胶层；11、凸起；2、感温变色层；3、薄膜层；31、孔隙。
具体实施方式
以下结合附图对本发明作进一步详细说明。
实施例1：
一种退热贴，结合附图1和附图2所示，自内向外依次为退热凝胶层1、感温变色层2和保护层，其中保护层为透明的薄膜层3，并且为了能够提高散热的效果，薄膜层3的表面还开设有若干的孔隙31，这样有利于人体产生的热量从孔隙31中散失出去。而感温变色层2是由变色材料二氢吲哚与聚氨酯以质量比为1：3进行混合的，这样有助于感温变色层2与薄膜层3和退热凝胶层1之间进行有效地粘结。从而当人体温度超过38.5度以后，感温变色层2的感温显色机制就会发生作用，将预设的图案显现出来。加之薄膜层3是透明的，因而便于提醒观察者对患者体温进行密切关注。
再者，退热凝胶层1背离薄膜层3的表面带有若干凸起11，且凸起11的表面为球面状，从而当退热贴贴合在患者额头上的时候，凸起11就会对额头进行挤压，使得皮肤被拉伸，从而有利于毛孔打开，这样也就有利于提高患者的散热。
另外，薄膜层还可以由聚乙烯醇、聚氨酯、热塑性聚氨酯、芳香族聚酰胺、醋酸纤维素、三醋酸纤维素、氰基纤维素、尼龙、聚丙烯晴、聚偏氟乙烯、聚丙烯、聚砜、聚醚砜、聚四氟乙烯、聚酯、聚碳酸、聚砜酰胺、聚醚酮、磺化聚砜、过氯乙烯、聚苯乙烯、聚苯醚、聚酰亚胺、硅橡胶、聚乙烯醚、聚醚酰胺、聚呋喃醇、磺化聚醚砜、聚乙烯、聚氯乙烯中的一种或任意几种主要材料组成。薄膜层还可以添加无毒增塑剂、交联剂、引发剂、带有双键 的单体、pH值调节剂、填料、染料、防腐剂和一些其它助剂。
实施例2：
一种退热贴的制备方法，如附图3所示，包括以下步骤：
a、分别秤取65Kg聚乙烯醇、4Kg戊二醛加入到混合器中，以100rpm搅拌速度进行混合，之后再秤取8Kg甘油、3Kg氢氧化钠、5.4Kg碳酰胺、3Kg氯化钙、4Kg珊瑚粉、10Kg 2-丙烯酰胺-2-甲基丙磺酸、2Kg阴离子表面活性剂和45Kg水加入到混合器中，并以200rpm搅拌速度再次进行混合，得到混合物；
b、将混合物加入到密炼炉中，温度升高至230℃进行熔融密炼，并得到熔融体，将熔融体转移至挤出机中拉伸挤出，冷却后得到薄膜层3，并利用冲压机在薄膜层3上冲压出若干孔隙31；
c、在薄膜层3上先涂布上与实施例一相同的感温变色层2，并将薄膜层3的边缘向感温变色层2方向翻折并包住感温变色层2的侧面，之后置于70℃的干燥箱中，对感温变色层2进行干燥；
d、将30Kg丙烯酰吗啉、8Kg2-丙烯酰胺-2-甲基丙磺酸、2Kg氢氧化钠、7Kg甘油、1Kg架桥剂KE-30、0.5Kg过氧化环己酮和1Kg交联剂DCP依次加入到反应器中，反应温度控制在120℃，时间控制在3小时，从而进行充分地反应混合，得到退热凝胶；
e、在干燥后的感温变色层2上及薄膜层带有感温变色层2的一侧表面的边缘处涂覆上退热凝胶，形成退热凝胶层1，并在退热凝胶层1背离感温变色层2的一侧压制出凸起11，再置于强度为600MJ/cm 2，温度为50℃的UV光照条件下固化，从而得到退热贴初成品；
f：利用固化槽对退热贴初成品进行包装，之后于室温下进行避光储存。
其中，珊瑚粉的制备方法：先配制50ml pH为8.0的亚硫酸钠缓冲溶液，用1ml曲拉通作为表面活性剂，并使用质量比为1：1：1的碱性蛋白酶、木瓜蛋白酶和胰蛋白酶的组合酶5g作催化；将亚硫酸钠缓冲溶液、曲拉通和组合酶三者混合得到酶液；将珊瑚浸泡于酶液中，控制恒温摇床温度为50℃，转速300r/min的条件下水解2小时；之后，将珊瑚研磨成平均粒度为10μm的珊瑚粉。其中，亚硫酸钠缓冲溶液的配制是现有技术，且并不是本申请的核心内容，因而不在此详细展开。
而本实施例2中的所选用的阴离子表面活性剂为十二烷基苯磺酸钠。
实施例3至实施例6以及对比例1和对比例2与实施例2的区别如下表一所示：
表一
Figure PCTCN2018105837-appb-000001
Figure PCTCN2018105837-appb-000002
并对实施例2至实施例6以及对比例1和对比例2进行抑菌、抗虫和退热时效的测试，抑菌测试：在退热贴的薄膜层3一面滴上两滴细胞培养液，然后将其置于25℃的环境中三天，观察其表面的细菌菌落(单位：cfu)；
杀虫测试：将退热贴的薄膜层3一侧朝上置于平均昆虫密度为10只/m 3的空间中，24小时之后观察剩下该环境下的昆虫密度(单位：只/m 3)；
退热时效：对100名常规感冒引起的发热患者进行使用测试，并计算每一患者平均退热所需的时间(单位：h)；
剥离强度：利用测力计与退热贴边缘固定好，然后拉动测力计，观察当退热贴被撕下时，测力计的读数。
所得结果如下表所示：
Figure PCTCN2018105837-appb-000003
Figure PCTCN2018105837-appb-000004
从上表可以看出本申请的退热贴具有良好的退热效果，同时其薄膜层3中还带有珊瑚粉、碳酰胺和十二烷基苯磺酸钠，而珊瑚粉的加入有效地增强了本申请退热贴的抗菌性能，而碳酰胺和十二烷基苯磺酸钠的协同作用使得本申请的退热贴具备了良好的杀虫功能，因而适合大规模推广使用。
本具体实施例仅仅是对本发明的解释，其并不是对本发明的限制，本领域技术人员在阅读完本说明书后可以根据需要对本实施例做出没有创造性贡献的修改，但只要在本发明的权利要求范围内都受到专利法的保护。
Figure PCTCN2018105837-appb-000005

Claims (8)

  1. 一种退热贴，自内向外依次包括退热凝胶层(1)、感温变色层(2)和保护层，其特征在于：所述保护层为透明的薄膜层(3)，所述保护层的边缘与退热凝胶层直接粘合在一起，而感温变色层(2)位于保护层和退热凝胶层(1)的中间处；
    所述薄膜层(3)按重量份数计，包括聚乙烯醇65～85份、戊二醛4～6份、甘油8～11份、氢氧化钠3～5份、碳酰胺5.4～6.5份、氯化钙3～5份、珊瑚粉4～6份、2-丙烯酰胺-2-甲基丙磺酸10～14份、阴离子表面活性剂2～4份和水45～55份；
    所述退热凝胶层(1)按质量计，包括丙烯酰吗啉30～40份、2-丙烯酰胺-2-甲基丙磺酸8～10份、氢氧化钠2～4份、甘油7～9份、架桥剂KE-30 1～2份、过氧化环己酮0.5～1.5份、交联剂DCP 1～2份。
  2. 根据权利要求1所述的一种退热贴，其特征在于：所述薄膜层(3)上开有若干孔隙(31)。
  3. 根据权利要求1所述的一种退热贴，其特征在于：所述阴离子表面活性剂为十二烷基苯磺酸钠。
  4. 根据权利要求1所述的一种退热贴，其特征在于：所述珊瑚粉由经过含有碱性蛋白酶、木瓜蛋白酶和胰蛋白酶的酶液处理的珊瑚制得。
  5. 根据权利要求1所述的一种退热贴，其特征在于：所述感温变色层(2)为二氢吲哚和聚氨酯的混合物，所述二氢吲哚和聚氨酯的质量比为1∶3。
  6. 根据权利要求1所述的一种退热贴，其特征在于：退热凝胶层(1)的表面带有若干凸起(11)。
  7. 如权利要求1至6中任意一项权利要求所述的一种退热贴的制备方法，包括以下步骤：
    步骤一、在薄膜层(3)上先涂布上感温变色层(2)，之后置于干燥箱中对感温变色层(2)进行干燥；
    步骤二、在感温变色层(2)上及薄膜层(3)带有感温变色层(2)一侧表面的边缘处涂覆退热凝胶层(1)，再次置于UV光条件下固化，从而得到退热贴初成品。
  8. 根据权利要求7所述的一种退热贴的制备方法，其特征在于：步骤一中待感温变色层(1)涂覆之后，将薄膜层(3)的边缘翻折包住感温变色层(2)的侧面。
PCT/CN2018/105837 2018-09-14 2018-09-14 一种退热贴及其制备方法 WO2020051914A1 (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2018/105837 WO2020051914A1 (zh) 2018-09-14 2018-09-14 一种退热贴及其制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2018/105837 WO2020051914A1 (zh) 2018-09-14 2018-09-14 一种退热贴及其制备方法

Publications (1)

Publication Number Publication Date
WO2020051914A1 true WO2020051914A1 (zh) 2020-03-19

Family

ID=69777390

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2018/105837 WO2020051914A1 (zh) 2018-09-14 2018-09-14 一种退热贴及其制备方法

Country Status (1)

Country Link
WO (1) WO2020051914A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111450048A (zh) * 2020-04-19 2020-07-28 田文超 一种退热贴用凝胶及其制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104817956A (zh) * 2015-04-02 2015-08-05 昆山联合环保涂料有限公司 一种珊瑚弹性涂料及其制备方法
CN205181584U (zh) * 2015-11-17 2016-04-27 上海卫生材料厂有限公司 温感变色退热贴
CN205698199U (zh) * 2016-04-20 2016-11-23 佛山市盛世泰康医药科技有限公司 一种具备实时观察贴剂水分变化和温度变化的退热贴
CN106283931A (zh) * 2016-07-08 2017-01-04 北京合益包装容器有限公司 一种植绒纸及其制备方法和由其制成的容器
CN108410105A (zh) * 2018-02-08 2018-08-17 武汉南雪药业有限公司 一种热敏感温水凝胶及双面透明膜变色退热贴

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104817956A (zh) * 2015-04-02 2015-08-05 昆山联合环保涂料有限公司 一种珊瑚弹性涂料及其制备方法
CN205181584U (zh) * 2015-11-17 2016-04-27 上海卫生材料厂有限公司 温感变色退热贴
CN205698199U (zh) * 2016-04-20 2016-11-23 佛山市盛世泰康医药科技有限公司 一种具备实时观察贴剂水分变化和温度变化的退热贴
CN106283931A (zh) * 2016-07-08 2017-01-04 北京合益包装容器有限公司 一种植绒纸及其制备方法和由其制成的容器
CN108410105A (zh) * 2018-02-08 2018-08-17 武汉南雪药业有限公司 一种热敏感温水凝胶及双面透明膜变色退热贴

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111450048A (zh) * 2020-04-19 2020-07-28 田文超 一种退热贴用凝胶及其制备方法
CN111450048B (zh) * 2020-04-19 2023-12-22 广州市雨纯生物科技有限公司 一种退热贴用凝胶及其制备方法

Similar Documents

Publication Publication Date Title
CN105670569B (zh) 一种相变复合微胶囊水凝胶及其物理退热贴
WO2010126018A1 (ja) 臓器モデル
JP4065691B2 (ja) プルラン膜組成物
TW394689B (en) Absorbent dressing for absorbing exudate from a wound
JPS61249341A (ja) 脱水用具
RU2458077C1 (ru) Биоразлагаемая пленка на основе пектина и хитозана
BR112012006651A2 (pt) cápsulas resistentes a ácido
JP4993519B2 (ja) 手術練習用または手術用切除具の切れ味の確認用の臓器モデル
JP4993518B2 (ja) 手術練習用または手術用切除具の切れ味の確認用の臓器モデル
CN110522948A (zh) 可注射水凝胶及其制备方法和应用
CN108410105B (zh) 一种热敏感温水凝胶及双面透明膜变色退热贴
CN105878209A (zh) 一种植物蛋白的空心胶囊及其制备方法
CN103611184A (zh) 一种复合半透膜的水凝胶及其制备方法
JP4675414B2 (ja) 臓器モデル
WO2020051914A1 (zh) 一种退热贴及其制备方法
CN110790953A (zh) 相变复合微胶囊水凝胶及退热贴
RU2545293C1 (ru) Способ получения биоразлагаемой пленки
CN109316275B (zh) 一种退热贴及其制备方法
JP2012224715A (ja) 水ジェル及びその製造方法、並びに保水ジェルマット及びその製造方法
CN114456404B (zh) 一种液态金属柔性可穿戴器件及其制备方法
JP2006274098A (ja) ゼラチンゲルの製造方法
CN106832366A (zh) 食品级蛋白膜的制备方法
CN211512270U (zh) 一种退热贴
JP2006274098A5 (zh)
JPS6315243B2 (zh)

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18933071

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18933071

Country of ref document: EP

Kind code of ref document: A1