WO2020012688A1 - Système de traitement par rayonnement et procédé de vérification de données de plan de traitement - Google Patents

Système de traitement par rayonnement et procédé de vérification de données de plan de traitement Download PDF

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WO2020012688A1
WO2020012688A1 PCT/JP2019/006028 JP2019006028W WO2020012688A1 WO 2020012688 A1 WO2020012688 A1 WO 2020012688A1 JP 2019006028 W JP2019006028 W JP 2019006028W WO 2020012688 A1 WO2020012688 A1 WO 2020012688A1
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radiation
monitor
irradiation
signal
treatment
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PCT/JP2019/006028
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English (en)
Japanese (ja)
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貴啓 山田
徹 梅川
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株式会社日立製作所
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

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  • the present invention relates to a radiation treatment system for irradiating a cancer affected part with radiation to perform cancer treatment, and a method for verifying treatment plan data.
  • Non-Patent Document 1 describes a patient-specific quality assurance (QA: Quality Assurance) of spot scanning proton beam therapy using SFUD (Single-Field Uniform Dose) for prostate cancer patients.
  • QA Quality Assurance
  • SFUD Single-Field Uniform Dose
  • Non-Patent Document 2 discloses three different methods for automatically restoring a planned dose in an intensity-modulated @ proton @ therapy (IMPT) on a daily CT image, and (1) a simple method using an optimization purpose of an initial plan. Dose restoration, (2) voxel-wise dose restoration, and (3) equi-dose restoration were performed and the results of comparison are described.
  • IMPT intensity-modulated @ proton @ therapy
  • Radiation therapy is a treatment method that irradiates a target tumor with radiation to damage the tumor.
  • X-rays are the most widely used radiotherapy, but the demand for particle beam therapy using particle beams represented by proton beams with high dose concentration and heavy particles such as carbon and helium is also growing. I have.
  • treatment plan data is created in which setting values of devices such as a radiation irradiation direction are stored for each patient. This treatment plan data is used for treatment after being verified by the patient QA.
  • Non-Patent Document 1 discloses completeness of data transfer as one of the verification items of the patient QA.
  • the particle beam is irradiated according to the treatment plan data at the gantry angle at the time of treatment without the patient on the treatment table, and it is confirmed that the particle beam treatment system operates properly.
  • Non-Patent Document 2 proposes an online adaptive treatment as a method of increasing the dose concentration on an affected part.
  • a treatment plan is adjusted based on a patient's anatomical structure measured on the treatment day, and then treatment is performed.
  • a patient is fixed on a treatment table, the patient is positioned at a position determined in advance by a treatment plan, and the particle beam is irradiated according to the treatment plan data.
  • online adaptive treatment it is determined based on patient images such as MRI images and CT images acquired on each treatment day whether or not a treatment plan needs to be modified.
  • the treatment is performed using the new treatment plan data re-planned in.
  • Patient images for each treatment day are acquired with the patient on the treatment table using an MRI apparatus or CT apparatus installed in the treatment room. This makes it possible to adjust the treatment plan in consideration of the condition of the patient on the day of the treatment, improve the concentration of the dose on the affected part, and reduce the dose applied to the normal tissue.
  • the present invention provides a radiation treatment system and a treatment planning data system capable of verifying the completeness of data transfer of treatment planning data while a patient is present in a treatment room. Provide a verification method.
  • the present invention includes a plurality of means for solving the above problems, a radiotherapy system for irradiating the affected part of the patient with radiation, to give an example, a radiation source for generating the radiation, A shielding unit that blocks radiation between the radiation source and the front of the patient, and a monitor signal simulator that simulates a signal of a radiation monitor while the radiation is blocked by the blocking unit.
  • Another example is a method of verifying treatment plan data in a radiation treatment system that irradiates an affected part of a patient with radiation, wherein the radiation treatment system includes a radiation source that generates the radiation, Blocking means for blocking radiation between the radiation source and the front of the patient, and a monitor signal simulating device that simulates a signal of a radiation monitor while the radiation is blocked by the blocking means, comprising: It is characterized in that the integrity of data transfer is verified without irradiating the radiation by blocking the radiation by the blocking means while the patient is in the room.
  • FIG. 2 is a diagram schematically illustrating a particle beam scanning irradiation nozzle of the particle beam therapy system according to the first embodiment. It is a figure which shows the layer irradiated with the same energy, a charged particle beam, and an irradiation spot at the time of scanning irradiation of an affected part. It is a figure which shows the dose distribution of the depth direction at the time of scanning irradiation of an affected part.
  • FIG. 4 is a diagram illustrating a display example of a display when mode switching of the overall control device is performed in the particle beam therapy system according to Embodiment 1.
  • FIG. 4 is a diagram illustrating a display example of a display when mode switching of the overall control device is performed in the particle beam therapy system according to Embodiment 1.
  • FIG. 2 is a diagram illustrating a flowchart of irradiation control in the particle beam therapy system according to Embodiment 1.
  • FIG. 3 is a diagram illustrating a time chart of control of scanning irradiation in a treatment mode in the particle beam therapy system according to Embodiment 1.
  • FIG. 3 is a diagram showing a time chart of scanning irradiation control in a monitor signal simulation mode in the particle beam therapy system according to Embodiment 1. It is a figure showing the whole particle beam therapy system composition of Embodiment 2 of the present invention. It is a figure showing the whole particle beam therapy system composition of Embodiment 3 of the present invention. It is a figure showing an example of the whole particle beam therapy system composition of Embodiment 4 of the present invention.
  • Embodiment 1 of a radiation therapy system and a method for verifying treatment plan data of the present invention will be described with reference to FIGS. 1 to 8.
  • FIG. 1 is a diagram showing the overall configuration of the particle beam therapy system according to the present embodiment.
  • the particle beam therapy system 100 is a system that irradiates the affected part 51 of the patient 5 with a particle beam.
  • the accelerator 20 the beam transport system 30, the irradiation nozzle 40, the treatment table 50, ,
  • An overall control device 11 an accelerator / beam transport system control device 12, an irradiation control device 13, a display 14, an input device 15, a beam cutoff device 46, and a monitor signal simulation device 47.
  • the accelerator 20 is a device that generates and accelerates a charged particle beam (hereinafter, referred to as a beam 90, see FIG. 2), and includes an injector 21 and a synchrotron accelerator 22.
  • the beam transport system 30 is a group of devices that transport the beam 90 accelerated by the accelerator 20 to the irradiation nozzle 40 that irradiates the affected part 51 with the beam 90, and connects the accelerator 20 and the irradiation nozzle 40.
  • the beam 90 accelerated to 60 to 70% of the speed of light by the accelerator 20 is transported to the irradiation nozzle 40 while being bent in a vacuum by a magnetic field by the bending electromagnet 31 arranged in the beam transport system 30.
  • the beam 90 is shaped by the irradiation nozzle 40 so as to conform to the shape of the irradiation area, and is irradiated to the irradiation target.
  • the irradiation target is, for example, the affected part 51 (see FIG. 2) of the patient 5 lying on the treatment table 50.
  • the overall control device 11 includes a treatment planning device (both not shown), an accelerator / beam transport system control device 12, an irradiation control device 13, a monitor signal simulation device 47, a display 14, an input device 15 via an OIS (Oncology Information System). , Etc., and controls the operation of the entire particle beam therapy system 100.
  • a treatment planning device both not shown
  • an accelerator / beam transport system control device 12 an irradiation control device 13, a monitor signal simulation device 47, a display 14, an input device 15 via an OIS (Oncology Information System). , Etc., and controls the operation of the entire particle beam therapy system 100.
  • OIS Oncology Information System
  • the accelerator / beam transport system controller 12 controls the operation of each device constituting the accelerator 20 and the beam transport system 30.
  • the irradiation control device 13 controls the operation of each device constituting the irradiation nozzle 40.
  • the display 14 and the input device 15 are a set of input / output devices, and display information based on signals obtained from the overall control device 11. Further, it receives an input from a medical worker operating the particle beam therapy system 100 and transmits various operation instruction signals to the overall control device 11.
  • the treatment table 50 is a bed on which the patient 5 is placed.
  • the treatment table 50 can move in directions of three orthogonal axes based on an instruction from the overall control device 11, and can move in a so-called six-axis direction that rotates around each axis. By these movement and rotation, the position of the affected part 51 of the patient 5 can be moved to a desired position.
  • FIG. 2 is a view schematically showing an irradiation nozzle 40 for scanning a particle beam.
  • FIG. 3 is a diagram showing a layer irradiated with the same energy, a charged particle beam 90, and an irradiation spot 53 when the affected part 51 is scanned and irradiated.
  • FIG. 4 is a diagram showing a dose distribution in the depth direction when the affected part 51 is scanned and irradiated.
  • a beam cutoff device 46 scanning electromagnets 41A and 41B, a dose monitor 42, a position monitor 43, a ridge filter 44, and a range shifter 45 are arranged.
  • the irradiation control device 13 includes an irradiation nozzle control device 13A, a dose monitor control device 72, a position monitor control device 73, a scanning magnet power supply control device 71, and scanning electromagnet power supplies 61A and 61B. I have.
  • the irradiation nozzle 40 is a device that scans the beam 90 in a two-dimensional plane by the scanning electromagnets 41A and 41B for scanning the beam 90 on a plane perpendicular to the passing direction of the beam 90.
  • the beam 90 scanned by the scanning electromagnets 41 ⁇ / b> A and 41 ⁇ / b> B is applied to the affected part 51.
  • the beam blocking device 46 retreats from the trajectory of the beam 90 to prevent the irradiation of the beam 90 from being hindered.
  • the dose monitor 42 is a monitor that collects electrons generated by the passage of the beam 90 in order to calculate the dose of the beam 90 applied to each spot.
  • the detection signal (pulse signal obtained by collecting electrons) of the dose monitor 42 is input to the dose monitor control device 72.
  • the dose monitor control device 72 calculates the dose irradiated on each irradiation spot 53 based on the detection signal input from the dose monitor 42, and outputs the calculated dose to the irradiation nozzle control device 13A.
  • the position monitor 43 is a monitor that collects electrons generated by the passage of the beam 90 in order to calculate the position of each irradiation spot 53 (for example, the position of the center of gravity).
  • a detection signal (a pulse signal obtained by collecting electrons) of the position monitor 43 is input to the position monitor control device 73.
  • the position monitor control device 73 counts the dose at each irradiation spot 53 based on the detection signal input from the position monitor 43, and outputs the calculated count value to the irradiation nozzle control device 13A.
  • the irradiation nozzle control device 13A calculates the passing position of the beam 90 based on the signal input to the position monitor control device 73, calculates the position and width of the irradiation spot 53 from the obtained passing position data, and irradiates the beam 90. Check the position. Further, the irradiation nozzle control device 13 ⁇ / b> A controls the irradiation of the beam 90 in accordance with the irradiation dose input to the dose monitor control device 72.
  • the beam cut-off device 46 is configured to block a particle beam between the accelerator 20 and the front of the patient 5.
  • the beam cut-off device 46 physically blocks the particle beam, and the beam blocker 46 a moves with respect to the trajectory of the particle beam. It has a moving mechanism 46b for moving forward / backward.
  • the blocker 46a is an object that collides with the beam 90 when placed on the trajectory of the beam 90, and prevents the beam 90 from reaching the patient 5.
  • the blocking body 46a is a metal block made of, for example, brass, and the moving mechanism 46b allows the beam 90 to retreat from the trajectory and to advance the beam 90 onto the trajectory.
  • the shielding body 46a may be further provided with a shielding structure such as a shielding material for the purpose of preventing the patient 5 from being exposed to the secondary radiation. desirable.
  • the moving mechanism 46b includes wheels mounted on the blocking body 46a, rails on which the wheels roll, a driving mechanism for moving the blocking body 46a, and the like.
  • the drive mechanism can be of various configurations such as a pneumatic type, a hydraulic type, a mechanical drive type by a motor, and the like.
  • the monitor signal simulating device 47 is a device that simulates a signal of the particle beam monitor while the beam blocking device 46 blocks the particle beam from reaching the affected part 51 of the patient 5.
  • a simulated monitor signal that simulates a signal output from the dose monitor 42 for measuring the irradiation amount of the particle beam and a signal output from the position monitor 43 for measuring the irradiation position of the particle beam is generated.
  • the particle beam monitor is composed of the dose monitor 42 and the position monitor 43, but any one of them may be used, and another type of monitor may be appropriately included.
  • the dose monitor simulation signal output from the monitor signal simulation device 47 is combined with the detection signal of the dose monitor 42 and input to the dose monitor control device 72.
  • the position monitor simulation signal output by the monitor signal simulation device 47 is combined with the detection signal of the position monitor 43 and input to the position monitor control device 73.
  • the monitor signal simulation device 47 may simulate at least one of a dose monitor simulation signal and a position monitor simulation signal.
  • the monitor signal simulating device 47 retracts the blocking member 46a of the beam blocking device 46 from the trajectory of the beam 90 in the treatment mode, and the blocking member 46a of the beam blocking device 46 in the monitoring signal simulating mode.
  • a signal is output to the moving mechanism 46b so as to advance the beam on the trajectory of the beam 90.
  • the ridge filter 44 can be used when it is necessary to increase the Bragg peak.
  • the range shifter 45 can be inserted when adjusting the arrival position of the beam 90.
  • FIG. 3 is a schematic diagram of the particle beam scanning irradiation.
  • the affected part 51 is divided into layers 52, and the inside of each layer 52 is irradiated with the beam 90 of the same energy.
  • One or more irradiation spots 53 are arranged in one layer 52.
  • the energy of the beam 90 is changed.
  • the position at which the beam 90 reaches the body changes.
  • the charged particle beam 90 having high energy reaches a deep position in the body, and the charged particle beam 90 having low energy reaches only a shallow position in the body.
  • the energy of the beam 90 is changed to form a uniform dose distribution in the depth direction, and the irradiation amount is appropriately distributed to form a depth-direction SOBP (Spread Out Bragg Peak).
  • SOBP Read Out Bragg Peak
  • the overall control device 11 of the present embodiment has two modes: a treatment mode for controlling the operation during treatment, and a monitor signal simulation mode for controlling the operation during verification of data transfer integrity. . Switching between the treatment mode and the monitor signal simulation mode is performed by the operator selecting a mode in accordance with the screen display displayed on the display 14 shown in FIG.
  • FIG. 6 shows a flowchart at the time of irradiation.
  • the treatment plan data for each patient 5 created in advance by the treatment planning device is stored in the OIS from the treatment planning device.
  • the overall control device 11 recognizes the mode (step S101).
  • the treatment plan data is sent from the OIS to the overall control device 11 of the particle beam therapy system 100 (step S102).
  • the overall control device 11 sets parameters of the treatment table 50, the accelerator / beam transport system control device 12, and the irradiation control device 13 based on the treatment plan data (step S103). In addition, the overall control device 11 sends data of the energy, coordinate value, and irradiation amount of each spot set based on the treatment plan data to the monitor signal simulation device 47 in addition to the irradiation control device 13.
  • the coordinate value of the irradiation spot 53 is converted into an excitation current value of the scanning electromagnets 41A and 41B by the irradiation control device 13 and sent to the scanning electromagnet power supply control device 71 shown in FIG.
  • step S104 After the setting of the parameters is completed, the irradiation is started by the operation of the operator (step S104).
  • the overall control device 11 determines that the irradiation spot 53 that has been irradiated earlier is in the same layer. It is determined whether or not the spot in 52 is the last spot to be irradiated (step S106). If it is determined that the spot is the last spot, the process proceeds to step S107. On the other hand, when it is determined that the spot is not the final spot, the process proceeds to step S105 to execute irradiation of the next irradiation spot 53.
  • the overall control device 11 determines whether or not the layer 52 to which a certain irradiation spot 53 to which irradiation has been completed previously belongs is the layer 52 to be irradiated last (step S107). If it is determined that the layer is the last layer 52, the process proceeds to step S108. If it is determined that the layer is not the last layer 52, the process is performed in step S105 to change the energy and irradiate the next layer 52. Proceed to
  • the overall control device 11 creates actual data including the irradiation position and the irradiation amount for each spot, and transfers the data to the OIS (step S108).
  • FIG. 7 shows a time chart of the scanning irradiation in the treatment mode.
  • FIG. 7 shows irradiation of three spots from spot 1 to spot 3 as an example.
  • a signal indicating that the treatment mode is set is output from the overall control device 11 to the monitor signal simulation device 47 before the irradiation.
  • the monitor signal simulating device 47 outputs a retreat signal to the moving mechanism 46b of the beam intercepting device 46, and retreats the interceptor 46a from the trajectory of the beam 90.
  • a command is issued from the accelerator / beam transport system controller 12 shown in FIG. 1 to the accelerator 20 so as to irradiate with a predetermined beam intensity.
  • the ionization output of the dose monitor 42 in the irradiation nozzle 40 is pulse-converted and output.
  • the pulse count value counted by the dose monitor control device 72 starts to increase, and when irradiating a predetermined dose, the dose monitor control device 72 sends an expiration signal to the irradiation nozzle control device 13A, and The irradiation ends.
  • the ionization output of the position monitor 43 is also pulse-converted and output as in the case of the dose monitor 42.
  • the position monitor control device 73 inputs the result of adding the signals for one spot to the irradiation nozzle control device 13A.
  • the irradiation nozzle control device 13A calculates the position and width of the spot based on the output signal of the position monitor control device 73, and determines whether or not a predetermined position has been irradiated. As a result of the determination, when the deviation between the spot position and the width is large, the beam 90 is stopped.
  • the irradiation nozzle control device 13A In response to the expiration signal from the dose monitor control device 72, the irradiation nozzle control device 13A sends a signal for the next spot movement to the scanning magnet power supply control device 71, and the movement to the next spot is started. When the current value of the next spot is reached, the scanning electromagnet power controller 71 sends a movement completion signal to the irradiation nozzle controller 13A.
  • the above is the control flow of the scanning irradiation in the treatment mode.
  • a signal indicating that the mode is the simulation mode is output from the overall control device 11 to the monitor signal simulation device 47 before the irradiation.
  • the monitor signal simulator 47 outputs a forward signal to the moving mechanism 46b of the beam interrupter 46, and advances the interrupter 46a on the trajectory of the beam 90.
  • the beam 90 can be prevented from being transported to the patient 5 by setting the blocking body 46 a of the beam blocking device 46 installed in the irradiation nozzle 40 on the trajectory of the beam 90.
  • the overall control device 11 downloads the treatment plan data from the OIS, and sends the energy, coordinate value, and irradiation amount data of each spot to the irradiation nozzle control device 13A and the monitor signal simulation device 47.
  • the monitor signal simulator 47 calculates, for each spot, the signal intensity of the dose monitor simulation signal and the position monitor simulation signal according to the energy, coordinate value, and irradiation amount.
  • the signal intensity is calculated based on a conversion formula or a conversion table using the spot energy, coordinate value, and irradiation amount as variables.
  • the calculation of the signal intensity may be performed when the treatment plan data is downloaded, or may be calculated sequentially when irradiating the spot.
  • the devices other than the monitor signal simulation device 47 and the beam cutoff device 46 operate in the same manner as in the treatment mode.
  • the accelerator 20 emits the beam 90 after accelerating the beam 90 to the energy based on the treatment plan data, and the beam transport system 30 transports the beam 90 to the irradiation nozzle 40.
  • the accelerator / beam transport system controller 12 inputs a spot irradiation timing signal to the monitor signal simulator 47 when emitting the beam 90.
  • the monitor signal simulation device 47 outputs a monitor simulation signal corresponding to the irradiation spot 53 using the spot irradiation timing signal as a trigger.
  • the irradiation nozzle control device 13A controls irradiation based on the monitor simulation signal.
  • FIG. 8 shows a time chart of scanning irradiation in the monitor signal simulation mode.
  • FIG. 8 also shows irradiation of three spots from spot 1 to spot 3, as in FIG.
  • a command is issued from the accelerator / beam transport system controller 12 shown in FIG. 1 to the accelerator 20 so as to irradiate with a predetermined beam intensity.
  • the beam 90 is blocked by the beam blocking device 46, so that the beam 90 does not pass through the dose monitor 42 and the position monitor 43, and no signal is output.
  • the accelerator / beam transport system controller 12 inputs a spot irradiation timing signal to the monitor signal simulator 47 when emitting the beam 90.
  • the monitor signal simulation device 47 outputs a dose monitor simulation signal and a position monitor simulation signal using the spot irradiation timing signal as a trigger.
  • the pulse count value counted by the dose monitor control device 72 starts increasing, and when the count reaches a predetermined count, the dose monitor control device 72 emits an expiration signal. It is sent to the nozzle control device 13A, and the irradiation of the spot ends.
  • the monitor signal simulator 47 While the spot is being irradiated, the monitor signal simulator 47 outputs a position monitor simulator signal in the same manner as the dose monitor simulator signal.
  • the position monitor control device 73 inputs the result of adding the signals for one spot to the irradiation nozzle control device 13A.
  • the irradiation nozzle control device 13A calculates the position and width of the spot based on the output signal of the position monitor control device 73, and determines whether or not a predetermined position has been irradiated. As a result of the determination, when the deviation between the spot position and the width is large, the beam 90 is stopped.
  • the irradiation nozzle control device 13A In response to the expiration signal from the dose monitor control device 72, the irradiation nozzle control device 13A sends a signal for the next spot movement to the scanning magnet power supply control device 71, and the change to the exciting current value of the next spot is started. Upon reaching the exciting current value of the next spot, the scanning electromagnet power supply control device 71 sends a movement completion signal to the irradiation nozzle control device 13A.
  • the above is the control flow of the scanning irradiation in the monitor signal simulation mode.
  • the monitor signal simulator 47 outputs a pulse signal.
  • This pulse signal simulates a signal output by performing IV conversion and VF conversion on the ionization current signal generated by the dose monitor 42 and the position monitor 43.
  • the effect of the present embodiment does not change even if the monitor simulation signal is output by simulating a voltage signal and synthesized with the monitor signal before VF conversion.
  • the above-described particle beam therapy system 100 irradiates an affected part 51 of a patient 5 with a particle beam.
  • the accelerator 20 generates and accelerates charged particles, and the accelerator 20 and the patient 5 And a monitor signal simulator 47 for simulating a particle beam monitor signal while the particle beam is cut off by the beam cutoff device 46. .
  • the beam blocking device 46 installed in the irradiation nozzle 40, the beam 90 is not transported downstream of the beam blocking device 46, and even if the patient 5 is in the treatment room.
  • the beam 90 is not irradiated.
  • devices other than the monitor signal simulation device 47 and the beam cutoff device 46 operate in the same manner as in the treatment mode. In other words, a series of data transfer in which the treatment plan data is acquired from the OIS, the beam 90 is accelerated, emitted, and transported according to the treatment plan data, and the actual data is created and transferred to the OIS is the same operation as in the normal treatment mode. do.
  • the blocking means is a beam blocking device 46 having a blocking member 46a for physically blocking the particle beam and a moving mechanism 46b for moving the blocking member 46a forward / backward with respect to the trajectory of the particle beam. It is possible to prevent the particle beam from reaching the patient 5 reliably.
  • the monitor signal simulating device 47 is a signal output from the dose monitor 42 for measuring the irradiation amount of the particle beam, and a signal output from the position monitor 43 for measuring the irradiation position of the particle beam.
  • the beam cutoff device 46 is installed in the irradiation nozzle 40 for irradiating the affected part 51 with the particle beam, it is possible to actually transport the particle beam to the vicinity of the patient 5. An operation method closer to the integrity verification method is possible.
  • FIG. 9 is a diagram illustrating a particle beam therapy system according to the present embodiment.
  • the particle beam therapy system 100A of the present embodiment is different from the particle beam therapy system 100 of the first embodiment in the function of the beam blocking device 46A.
  • the configuration and operation of the particle beam therapy system 100A are substantially the same as those of the particle beam therapy system 100 of the first embodiment except for the beam cutoff device 46A and the monitor signal simulation device 47A, and the details are omitted.
  • the blocking body 46a1 of the beam blocking device 46A in the particle beam therapy system 100A of the present embodiment measures the dose of the particle beam for measuring the dose of each spot when the beam 90 is blocked. It further has a dosimeter. The spot irradiation amount measured by the dosimeter is input to the monitor signal simulator 47A.
  • the monitor signal simulator 47A generates a dose monitor simulation signal based on the input spot irradiation amount, and inputs the generated signal to the dose monitor controller 72.
  • the blocking member 46a1 of the beam blocking device 46A is, for example, a Faraday cup that is a metal (conductive) cup that captures charged particles in a vacuum, or an ionization chamber and brass installed downstream of the ionization chamber. Etc. (preferably the same configuration as that described in the first embodiment).
  • the blocking body 46a1 When the blocking body 46a1 is a Faraday cup, the blocking body 46a1 itself functions as a dosimeter and a blocking body. In the case of ionization chambers and blocks, the ionization chamber is a dosimeter and the block is a blocker.
  • the radiation therapy system and the method for verifying treatment plan data according to the second embodiment of the present invention also provide substantially the same effects as the radiation treatment system and the method for verifying treatment plan data according to the first embodiment.
  • the beam cut-off device 46A further has a dosimeter for measuring the dose of the particle beam, and the monitor signal simulating device 47A outputs a signal of the particle beam monitor based on the dose of the particle beam measured by the dosimeter.
  • FIG. 10 is a diagram illustrating a particle beam therapy system according to the present embodiment.
  • the particle beam therapy system 100B according to the present embodiment is different from the particle beam therapy system according to the first embodiment in that a beam position monitor 43B and a metal block are used as the beam blocking device 46B (the same structure as that described in the first embodiment). Is different in that it is installed.
  • the configuration and operation of the particle beam therapy system 100B are substantially the same as those of the particle beam therapy system 100 of the first embodiment except for the beam position monitor 43B and the monitor signal simulation device 47B, and the details are omitted.
  • the beam blocking device 46B in the particle beam therapy system 100B of the present embodiment further includes a beam position monitor 43B that measures the irradiation position of the particle beam. Measure the irradiation position for each. The measured spot irradiation position is input to the monitor signal simulator 47B.
  • the monitor signal simulation device 47B generates a position monitor simulation signal based on the input spot irradiation position, and inputs the generated signal to the position monitor control device 73.
  • the radiation therapy system and the method for verifying treatment plan data according to the third embodiment of the present invention also provide substantially the same effects as the radiation treatment system and the method for verifying treatment plan data according to the first embodiment.
  • the beam cutoff device 46B further includes a beam position monitor 43B for measuring the irradiation position of the particle beam, and the monitor signal simulating device 47B performs the measurement based on the irradiation position of the particle beam measured by the beam position monitor 43B.
  • the monitor signal simulating device 47B performs the measurement based on the irradiation position of the particle beam measured by the beam position monitor 43B.
  • the beam position monitor 43B in addition to measuring the irradiation position for each spot by the beam position monitor 43B, it is also possible to measure the irradiation amount for each spot when the beam 90 is cut off as described in the second embodiment. it can.
  • FIGS. 11 to 13 are views showing the particle beam therapy system according to the present embodiment.
  • the particle beam therapy system 100C of the present embodiment is different from the particle beam therapy system 100 of the first embodiment in that the beam blocking device 46C transports the particle beam from the accelerator 20 to the irradiation nozzle 40. Is installed in the beam transport system 30 of FIG.
  • the beam blocking device 46C has the same configuration and function as the beam blocking device 46 described in the first embodiment, the beam blocking device 46A described in the second embodiment, and the beam blocking device 46B described in the third embodiment. can do.
  • the monitor signal simulator 47C can have the same configuration and function as the monitor signal simulators 47, 47A, and 47B described in the first to third embodiments.
  • the monitor signal simulation device 47C of the present embodiment is In the monitor signal simulation mode, it is desirable to output a simulation signal to these beam monitors as needed.
  • the configuration and operation of the particle beam therapy system 100C are the same as those of the first embodiment except for the beam cutoff device 46C and the monitor signal simulating device 47C, and the details are omitted.
  • the beam cutoff device 46C is installed in the beam transport system 30 for transporting the particle beam from the accelerator 20 to the irradiation nozzle for irradiating the diseased part 51, so that the source of the secondary radiation accompanying the beam cutoff is provided. Can be kept away from the treatment room. This makes it possible to simplify the shielding structure for avoiding exposure of the patient 5 due to the secondary radiation.
  • the position of the beam blocking device 46C in the beam transport system 30 is not limited to the position as shown in FIG. 11 as in the present embodiment, and as shown in FIG.
  • the monitor signal simulator 47D can have the same configuration as the monitor signal simulators 47, 47A, 47B, and 47C.
  • the beam cutoff device 46E can be installed downstream of the emission point of the accelerator 20.
  • the beam transport system 30 has a sorting device 32 for sorting radiation to a plurality of irradiation nozzles 40. For this reason, the beam cutoff device 46E can be installed on the upstream side of the distribution device 32.
  • the distribution device 32 is configured by an electromagnet or the like.
  • the monitor signal simulator 47E can have the same configuration as the monitor signal simulators 47, 47A, 47B, and 47C, but must be connected to the plurality of irradiation nozzles 40, respectively. At the time of verification, a monitor simulation signal is output to the irradiation nozzle 40 to be verified among the plurality of irradiation nozzles 40.
  • monitor signal simulation device 47E does not need to be one, and may be provided to the irradiation nozzle 40 on a one-to-one basis.
  • the beam transport system 30 includes a distribution device 32 for distributing radiation to the plurality of irradiation nozzles 40, and a beam cutoff device 46E is installed upstream of the distribution device 32.
  • a beam blocking device in each of a plurality of treatment rooms.
  • existing facilities such as a Faraday cup provided in the beam transport system 30 can be effectively used. That is, a mechanism for cutting off the beam can be provided with minimum effort.
  • FIG. 14 is a diagram illustrating a particle beam therapy system according to the present embodiment.
  • the particle beam therapy system 100F of the present embodiment shown in FIG. 14 is different from the particle beam therapy system 100 of the first embodiment in the method of blocking the beam 90.
  • Other configurations and operations of the particle beam therapy system 100 are the same as those of the first embodiment except for the beam cutoff method and the monitor signal simulation device 47F, and therefore, the details are omitted.
  • the particle beam therapy system 100F of the present embodiment shown in FIG. 14 physically blocks the beam 90 using the beam blocking devices 46, 46A, 46B, 46C, 46D, and 46E as in the first to fourth embodiments. Instead, the beam 90 is cut off under the control of the accelerator 20.
  • control is performed to block the beam 90 by not entering the beam 90 into the accelerator 20 or by entering or accelerating but not emitting the beam 90.
  • control include, for example, shutting off the supply of the source gas to the injector 21, shutting off the supply of electric power to each device constituting the injector 21, adjusting the control parameters, and controlling each device in the accelerator 20. It is conceivable to cut off the supply of electric power or adjust control parameters (such as using a control parameter different from that for acceleration).
  • the monitor signal simulating device 47F In order to prevent the irradiation control from stalling due to not entering or exiting the beam 90, the monitor signal simulating device 47F generates a signal simulating the signal of the beam monitor in the accelerator 20 or the beam transport system 30, and performs each control. Input to the device.
  • the interrupting unit is the accelerator / beam transport system control device 12F. .
  • the radiation therapy system and the method for verifying treatment plan data according to the fifth embodiment of the present invention also provide substantially the same effects as the radiation treatment system and the method for verifying treatment plan data according to the first embodiment.
  • shutoff means is an accelerator / beam transport system control device 12F that shuts off the generation and acceleration of the particle beam in the accelerator 20, or cuts off the emission of the particle beam from the accelerator 20, the additional equipment is monitored. Since only the signal simulating device 47F is used, and there is no need to newly add a device such as the beam cutoff device 46, it is possible to easily apply the present invention to an existing device.
  • the beam 90 can be cut off by the control in the accelerator 20 but also the beam 90 can be cut off by the control in the beam transport system 30.
  • the beam 90 can be realized by cutting off the supply of power to each device in the beam transport system 30, adjusting control parameters, and the like.
  • Embodiments 1 to 4 it is possible to provide a beam cutoff device in the beam transport system 30 or the irradiation nozzle 40 to ensure completeness.
  • a part of the configuration of one embodiment can be replaced with the configuration of another embodiment, and the configuration of another embodiment can be added to the configuration of one embodiment. Further, for a part of the configuration of each embodiment, it is also possible to add, delete, or replace another configuration.
  • the discrete spot irradiation method in which the beam current is stopped between spots is described as an example, but the present invention can be similarly applied to a continuous spot irradiation method in which the beam current is not stopped between spots.
  • an irradiation method of forming a dose distribution according to the shape of a target using a collimator or a bolus after broadening a particle beam distribution such as a Wobbler method or a double scatterer method may be applied to the present invention. Can be.
  • accelerator 20 in addition to the synchrotron accelerator described in the first to fifth embodiments, various known accelerators such as a cyclotron accelerator and a synchrocyclotron accelerator can be used.
  • the radiation source that generates radiation is not only the charged particle accelerator 20 as in the first to fifth embodiments, but also an X-ray therapy apparatus using an electron linear accelerator in which the generated radiation is X-rays, or the generated radiation.
  • a gamma ray therapy apparatus using a gamma ray source which is a gamma ray is possible.
  • the monitor signal simulator simulates the signals of the dose monitor and the collimator position monitor. Otherwise, the configuration can be the same as in the first to fifth embodiments.
  • Beam transport system 32 Distributing device 40: Irradiation nozzles 41A, 41B ... Scanning magnet 42 ... Dose monitor 43 ... Position monitor 43B ... Beam position monitor 44 ... Ridge filter 45 ... Range shifters 46, 46A, 46B, 46C, 46D, 46E ... Beam blocking device 46a ... Blocking body 46b ... Moving mechanism 47, 47A, 47B, 47C, 47D, 47E, 47F ... Monitor signal simulating device 5 ...
  • Patient 50 ... Treatment table 51 ... Affected part 52 ... Affected part layer irradiated with the same energy 53 Irradiation spots 61A, 61B Scanning magnet power supply 71 Scanning magnet power supply controller 72 Dose monitor controller 73 Position monitor controller 90 Beams 100, 100A, 100B, 100C, 100D, 100E, 100F Particle beam therapy System (radiation therapy system)

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

Un système de traitement par rayonnement 100 pour irradier un faisceau de particules vers une partie affectée 51 d'un patient 5 est pourvu d'un accélérateur 20 pour générer et accélérer des particules chargées, d'un dispositif de coupure de faisceau 46 pour couper le faisceau de particules entre l'accélérateur 20 et devant le patient 5, et d'un dispositif de simulation de signal de surveillance 47 pour simuler un signal d'un dispositif de surveillance de faisceau de particules tandis que le faisceau de particules est coupé par le dispositif de coupure de faisceau 46. Grâce à cette configuration, il est possible de vérifier l'intégrité de transfert de données de données de plan de traitement pendant que le patient est présent dans une salle de traitement.
PCT/JP2019/006028 2018-07-12 2019-02-19 Système de traitement par rayonnement et procédé de vérification de données de plan de traitement WO2020012688A1 (fr)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006107637A1 (fr) * 2005-04-01 2006-10-12 Wisconsin Alumni Research Foundation Machine de thérapie par radiation à intensité modulée à faible champ
JP2016220753A (ja) * 2015-05-27 2016-12-28 株式会社日立製作所 粒子線治療システム
JP2018094147A (ja) * 2016-12-14 2018-06-21 住友重機械工業株式会社 荷電粒子線治療装置

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006107637A1 (fr) * 2005-04-01 2006-10-12 Wisconsin Alumni Research Foundation Machine de thérapie par radiation à intensité modulée à faible champ
JP2016220753A (ja) * 2015-05-27 2016-12-28 株式会社日立製作所 粒子線治療システム
JP2018094147A (ja) * 2016-12-14 2018-06-21 住友重機械工業株式会社 荷電粒子線治療装置

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