WO2020001352A1 - Use of calcium quinoline for preventing a plant disease and a composition of calcium quinoline - Google Patents

Abstract

The present invention relates to use of calcium quinoline for preventing a plant disease and a composition of calcium quinoline. The plant disease prevented by calcium quinoline comprises one or more of a plant fungal disease, a plant bacterial disease, or a plant nutrition deficiency disease caused by calcium deficiency. According to the present invention, it is found that calcium quinoline does not cause heavy metal pollution in soil and heavy metal residues in crops, and it is found that by means of the action of calcium quinoline, the absorption of calcium by crops can be enhanced and the resistance of plants to some germs can be enhanced, thereby avoiding or reducing the invasion and occurrence of germs. The present invention has a long-lasting effect on crop disease prevention.

Description

Application of quinoline calcium for controlling plant diseases and composition thereof Technical field

The present invention belongs to the field of fungicides and plant growth regulators, relates to the use of quinoline calcium to prevent plant diseases or to prevent plant diseases caused by calcium deficiency, and also relates to pesticide compositions containing quinoline calcium, uses of pesticide compositions and pesticides. Method of applying the composition.

Background technique

Fungicides are compounds that have a toxic effect on pathogenic microorganisms. The principle of fungicides to control plant diseases is divided into three types, namely chemical protection, chemical treatment and chemical immunity. On the one hand, fungicides are directly toxic to germs, and on the other hand, fungicides change the metabolism of plants and change their plant's response to germs or the pathogenic process of germs. However, most systemic fungicides have only one effect, and some fungicides have both functions.

A method for preparing quinoline calcium has been disclosed in the prior art. For example, J. Fluoresc (2012) 22: 1271-1279, I.M. Nagpure et al. Disclosed "Synthesis, Thermal and Spectroscopic Characterization of Caq2 (Calcium 8-Hydroxyquinoline) Organic Phosphor". There is also a method for preparing 8-hydroxyquinoline calcium as disclosed in CN105348191B, and there is a method for preparing 8-hydroxyquinoline calcium as disclosed in CN105439950A.

Although the method of 8-hydroxyquinoline calcium is disclosed in the prior art, the application of calcium quinoline is limited to organic electroluminescent materials, and it does not involve agricultural applications.

Among the copper preparations currently used in pesticides, especially copper quinoline, on October 27, 2017, the list of carcinogens published by the International Cancer Research Organization of the World Health Organization was initially compiled and referenced. 8-hydroxyquinoline copper was classified as a type 3 carcinogen. List. The application of copper quinoline has been greatly restricted, but as a substitute product of copper quinoline, it is still in short supply on the market.

The present invention not only finds that quinoline calcium can control plant diseases, but also finds that its effect on plant disease control is better than that of current similar plant disease control agents.

Summary of the invention

In order to solve the above technical problems, the present invention provides an application of a compound having the following chemical formula A for plant disease control, the chemical formula of the compound having the chemical formula A is as follows:

The plant disease is one or more of a plant fungal disease, a plant bacterial disease or a plant deficiency caused by calcium deficiency.

Preferably, the plant diseases are plant fungal diseases and plant auxotrophies caused by calcium deficiency.

Preferably, the plant diseases are plant bacterial diseases and plant auxotrophies caused by calcium deficiency.

The compound of the above-mentioned chemical formula A is hereinafter also simply referred to as calcium quinoline or 8-hydroxyquinoline calcium salt.

Preferably, in the above application, the plant is preferably a crop, and the crop is selected from any crop of cereals, fruit trees, vegetables, sugar plants, oil crops, tobacco or tea trees.

Specifically, cereals such as wheat, barley, rice, sorghum; fruit trees such as apple, pear, peach, citrus, grape, lychee, banana, longan, mango, loquat; vegetables such as cucumber, watermelon, hanging melon, loofah, and melon , Spinach, celery, tomato, pepper, eggplant, ginger, shallot, garlic, leek, kale, Chinese cabbage, strawberry, lettuce, kidney bean, cowpea, broad bean, radish, carrot, potato, yam, taro, lotus root, coriander, lotus root, Sweet potatoes; sugar plants such as sugar beet and sugar cane; oil crops such as soybean, peanut, rape, sesame, sunflower. This listing does not imply any limitation.

Preferably, in the above application, plant diseases are controlled by applying quinoline calcium to plants and plant parts.

Among them, plant parts are all above-ground and underground parts and plant organs, such as buds, leaves, flowers and roots, such as leaves, needles, stems, stems, flowers, fruiting bodies, fruits and seeds, and roots, tubers and rhizomes. Plant parts also include harvested materials and asexual and sexually propagating materials such as seedlings, tubers, rhizomes, cuttings and seeds. Plants and above-ground and underground parts and plant organs, such as buds, leaves, flowers, and roots, such as leaves, needles, stems, stems, flowers, and fruits are preferably treated.

Preferably, in the use of the above compound for the control of plant diseases, the plant diseases are rice leaf blight, rice base rot, cucumber keratosis, early tomato blight, bacterial stripe of rice, late blight of tomato, Apple spotted leaf disease, grape downy mildew, or peach bacterial perforation.

Preferably, in the use of the above compounds for plant disease control, the effective amount of the compound for controlling plant diseases is 15-1500 g / ha, and preferably, the effective amount of the compound for controlling plant diseases is 100-500 g / ha.

In another aspect, the present invention also provides a pharmaceutical composition for controlling plant diseases, the composition comprising a compound of the following formula A and an agricultural, forestry or sanitaryly acceptable auxiliary agent and a carrier,

Wherein, the weight of the compound having the chemical formula A accounts for 1-99% of the weight of the pharmaceutical composition, and the sum of the weight of the adjuvant and the carrier accounts for 1-99% of the weight of the pharmaceutical composition.

Preferably, in the above pharmaceutical composition for controlling plant diseases, the dosage form of the pharmaceutical composition is a suspending agent, a suspoemulsion, a water-dispersible granule, or a wettable powder.

Preferably, the adjuvant or carrier in the pharmaceutical composition includes a wetting agent, a dispersant, a thickener, an antifreeze, a preservative, a stabilizer, a film forming agent, a capsule forming agent, a pH acid-base adjusting agent, an antifoaming agent, and a coloring agent. Agents, fillers, water, and other known substances that are useful for the stabilization of active ingredients or active compounds in the formulation are all ingredients commonly used in preparation or permitted in agriculture, and are not particularly limited. The specific ingredients and dosages are based on Need to be determined through experiments.

The humectant is selected from the group consisting of EO / PO block polyether, fatty alcohol polyoxyethylene ether, tallow ethoxy ammonium salt, alkyl naphthalene sulfonate, fatty alcohol polyoxyethylene ether sulfate, and acyl glutamic acid. One or more of the salts;

The dispersant is selected from the group consisting of naphthalenesulfonic acid condensate sodium salt, phenolsulfonic acid condensate sodium salt, sodium methylnaphthalenesulfonate formaldehyde condensate, sodium ligninsulfonate, sodium methylene dinaphthalenesulfonate, and acrylic acid homopolymerization. One or more of sodium salt, polymer polycarboxylate, dioctylsulfosuccinate sodium salt, EO / PO block polyether, and maleic acid-acrylic acid copolymer sodium salt;

The thickener is selected from one or more of xanthan gum, aluminum magnesium silicate, sodium carboxymethyl cellulose, sodium starch phosphate, sodium octenyl succinate, and polyvinyl alcohol;

The antifreeze is selected from one or more of ethylene glycol, propylene glycol, glycerol, isopropanol, and urea;

The film-forming agent is selected from the group consisting of polyvinyl alcohol, polyvinyl acetate, polyethylene glycol, polyethylene glycol methacrylate, carboxymethyl cellulose, gum arabic, xanthan gum, and starch. And film-forming polymer;

The encapsulating agent is a polyurea resin; it is prepared by an interfacial polymerization reaction between an isocyanate monomer and a polyol or a polyamine; the isocyanate includes toluene diisocyanate, 4,4-diphenylmethane diisocyanate, and polyphenylene. Methyl polyisocyanate, polyphenyl polymethylene polyisocyanate, etc.

The pH acid-base adjusting agent is selected from one or more of citric acid, glacial acetic acid, hydrochloric acid, ammonia, triethanolamine, and diethylenetriamine; the required amount is to adjust the pH value of the final product to a stable range as: should;

The defoaming agent is selected from a silicone defoamer and / or a polyether defoamer;

The colorant is selected from one or more of iron oxide, titanium oxide and azo dye;

The filler is selected from one or more of kaolin, diatomaceous earth, talc, light calcium carbonate, and white carbon black;

The water is deionized water or distilled water.

Preferably, in the above pharmaceutical composition for controlling plant diseases, the weight content of the compound having the chemical formula A in the pharmaceutical composition is 20-60%.

The present invention also provides the use of the above-mentioned pharmaceutical composition for controlling plant diseases, the plant diseases being one or more of plant fungal diseases, plant bacterial diseases or calcium deficiency caused by calcium deficiency.

Preferably, in the use of the pharmaceutical composition for controlling plant diseases, the weight content of the compound in the pharmaceutical composition is 20-60%, and the dilution factor is 100-4000 times when applied.

Preferably, in the use of the pharmaceutical composition for controlling plant diseases, the plant diseases are rice leaf blight, rice base rot, cucumber corner spot disease, tomato early blight, rice bacterial stripe disease, tomato late blight, Apple spotted leaf disease, grape downy mildew, or peach bacterial perforation.

The present invention also provides the method for controlling plant diseases by the above-mentioned pharmaceutical composition, which is characterized in that the pharmaceutical composition is applied to the plant of the disease to be controlled at an effective dose of 15 to 1500 grams of quinoline calcium per hectare or to control harmful bacteria. Or fungal media. Preferably, the pharmaceutical composition is applied at an effective dose of 100 to 300 grams of calcium quinoline per hectare to a plant to be controlled for a disease or to a medium for controlling harmful bacteria or fungi.

In the process of preventing and controlling plant diseases, the above-mentioned pharmaceutical composition can be sprayed, seeded, watered, sprinkled, or brushed according to the nature of the target disease. The amount of effective active ingredients applied varies with weather conditions, plant conditions, or Application methods can also be adjusted and changed.

Beneficial effects of the present invention

The present invention finds that quinoline calcium has more excellent disease prevention and treatment effects than similar agents such as copper quinoline, zinc quinoline, and zinc thiazole, and can use a smaller amount of quinoline copper to prevent and treat diseases.

The present invention finds that quinoline calcium has good safety and disease prevention and treatment effects on some crops (peaches, apples) sensitive to copper preparations.

The present invention finds that quinoline calcium does not cause soil heavy metal pollution and crop heavy metal residues, and it is found that through the action of quinoline calcium, plants can enhance the absorption of calcium by crops and enhance the plant's resistance to some germs, thereby avoiding or reducing germs Damage and occurrence, the long-term duration of crop disease control.

detailed description

In order to make the objectives, technical solutions, and advantages of the present invention clearer, the present invention is illustrated by the following specific examples, which are used to better explain the present invention, rather than limiting the protection scope of the present invention. Any modification and change made within the basic idea and principle of the invention belong to the scope of protection claimed by the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the claims.

Examples of indoor biometrics:

The original quinoline calcium medicines and preparations used in this test were provided by Jiaxing Shicheng Trading Co., Ltd .; the strains of the bioassay test were provided by the Laboratory of Plant Protection, Zhejiang Agriculture and Forestry University, College of Agriculture, Yangtze University, and College of Agriculture, Jilin Agricultural Science and Technology University Yes, usually stored on (PDA) slope at 4 ° C.

Indoor bioassay example 1: Antibacterial experiment of Xanthomonas oryzae pv. Oryzae

Test method: Oxford standard method (coating method), each of the following data is the total of 9 cups of bacteriostatic area. The test agents were 96% quinoline calcium powder, 96% quinoline zinc powder, 95% thiazole zinc powder, and 99% copper quinoline standards. The test concentrations of all the drugs were 20, 4, and 2 mg / L.

The test results show that: against rice leaf blight, quinoline calcium and copper quinoline have high bacteriostatic activity, the quinoline calcium activity is significantly higher than that of copper quinoline at high concentrations, and the difference is not significant at low concentrations; Zinc quinoline and zinc thiazole, which is currently used as a conventional control agent, did not show activity on the plate test. The specific results are shown in Tables 1 and 2 below.

Table 1: Antibacterial effect on rice leaf blight by 24 hours and 48 hours

Table 2: Antibacterial effect on rice leaf blight by 72 hours and 96 hours

Indoor bioassay example 2: Antibacterial experiment of rice-based rot fungi

Test method: Oxford standard method (coating method), each of the following data is the total of 9 cups of bacteriostatic area. The test agents were 96% quinoline calcium powder, 96% quinoline zinc powder, 95% thiazole zinc powder, and 99% copper quinoline standards. The test concentrations of all the drugs were 20, 4, and 2 mg / L.

The test results show that: quinoline calcium and copper quinoline have high bacteriostatic activity against rice-based rot fungi. At high concentrations, the activity of calcium quinoline is significantly higher than that of copper quinoline. Zinolinium and the current conventional control agent, thiazolezinc, did not show activity on the plate test. The specific results are shown in Tables 3 and 4 below.

Table 3: Antibacterial effect on rice-based rot fungi at 24 hours and 48 hours

Table 4: Antibacterial effect on rice-based rot fungi at 72 hours and 96 hours

Laboratory bioassay example 3: Antibacterial test of cucumber spotted bacterium

Test method: Oxford standard method (coating method), each of the following data is the total of 9 cups of bacteriostatic area.

The test agents were 96% quinoline calcium powder, 96% quinoline zinc powder, 95% thiazole zinc powder, and 99% copper quinoline standards. The test concentrations of all the drugs were 20, 4, and 2 mg / L.

The test results show that: against cucumber leaf spot bacteria, calcium quinoline, zinc quinoline, and copper quinoline have certain antibacterial activity, copper quinoline is slightly better than calcium quinoline, and quinoline calcium is slightly better than zinc quinoline; No activity was shown on the plate test. The specific results are shown in Table 5 below.

Table 5: Antibacterial effects of rice-based rot fungi at 24, 48 and 72 hours

Indoor bioassay example 4: Antibacterial test of Phytophthora infestans

Test method: Oxford standard method (coating method), each of the following data is the average of the 6 cup colony radius. The test agents were 96% quinoline calcium powder, 96% quinoline zinc powder, and 99% copper quinoline standard.

The test results show that: against tomato early blight, quinoline calcium, quinoline zinc, and quinoline copper have good bacteriostatic activity. Quinoline calcium is slightly better than quinoline zinc and copper quinoline, but the activity of the three is not significantly different. For specific results, see Table 6 below.

Table 6: The antibacterial effect of antibacterial agents on Phytophthora infestans

Field efficacy test:

Field test example 1: control of rice bacterial streak

The pathogen of rice bacterial streak is Xanthomonas oryzae pv.oryzicola.

Test method: The field efficacy test was carried out in accordance with the Ministry of Agriculture's pesticide field efficacy test guidelines (I) (Guidelines for fungicide control of rice leaf diseases), which was conducted in August 2017 in Wenzhou, Zhejiang. The test agents were 33% copper quinoline SC (produced by Zhejiang Hisun Chemical Co., Ltd.), 20% thiazole zinc SC (produced by Zhejiang Xinnong Chemical Co., Ltd.), and 2% kasugamycin AS (Jiangmen Plant Protection Service Co., Ltd.). ); 20% calcium quinoline SC (provided by Jiaxing Shicheng Trading Co., Ltd.), the water spray per hectare is 675 kg.

Field tests show that for rice bacterial streak, 20% quinoline calcium SC600 solution, 20% thiazole zinc SC600 solution is better than 2% kasugamycin AS 400 times solution, and significantly better than 33% copper quinoline SC1000 liquid control effect. The specific results are shown in Table 7 below.

Table 7: Control effect of antibacterial agent on rice bacterial streak

Field test example 2: Control of apple spotted leaf disease

The pathogen of apple spotted leaf disease is (Alternaria alternaria f.sp. mali).

Test method: Refer to the Ministry of Agriculture ’s Field Efficacy Test Guideline (I) (Part 124 of the Efficacy Test Guideline for Fungicides to Control Apple Spot and Leaf Disease). The field efficacy test was conducted in April-July 2017 in Xiaoxian, Anhui. get on. The test drug was 430g / L tebuconazole SC (produced by Bayer Crop Science Co., Ltd.), 60% quinoline calcium WP (provided by Jiaxing Shicheng Trading Co., Ltd.), and the drug was administered before the onset of spotted leaf disease, and it was applied every 15 days. , The common medicine 6 times, each spray of 675 kg per hectare.

The field test showed that: 60% quinoline calcium WP4000 times solution is slightly better than 430g / L tebuconazole SC 4000 times control effect on apple spotted leaf disease. The specific results are shown in Table 8 below.

Table 8: Antibacterial effect on apple spotted leaf disease

In the process of apple tree disease control, copper quinoline has phytotoxic effects on the young leaves of apple trees during flowering period, while calcium quinoline has no phytotoxic effects.

Field test example 3: control of grape downy mildew

The pathogen of grape downy mildew is (Plasmopara viticola (Berk.dt Curtis) Berl. EtdeToni).

Test method: The field efficacy test was conducted in accordance with the Ministry of Agriculture's pesticide field efficacy test guidelines (1) (Guidelines for bactericide control of grape downy mildew disease), and the tests were carried out in September-October 2017 in Jinhua, Zhejiang. The test agents were 100 g / L cyanazoxazole SC (produced by Ishihara Industry Co., Ltd.), 30% quinoline calcium SC (provided by Jiaxing Shicheng Trading Co., Ltd.), and the drug was used at the beginning of grape downy mildew. The medicine was sprayed once and the medicine was sprayed twice, and the water spraying amount per hectare was 675 kg.

Field tests show that: 30% quinoline calcium SC has a better control effect on the disease when used in the early stage of grape downy mildew disease, and its efficacy is equivalent to that of 100 g / l cyanazolam SC 2000 times. The results are shown in Table 9 below.

Table 9: Antibacterial effect on grape downy mildew

Field test example 4: control of peach tree bacterial perforation

The pathogen of peach tree bacterial perforation is (Xanthomonus pruni (Smith) Dowson.).

Test method: Grade 5 of diseased leaves is used: Grade of diseased leaves: Grade 0, no disease spots on the whole leaf; Grade 1, there are 1 to 5 spots on each leaf; Grade 2, there are 6 to 6 spots on each leaf 10; level 3 with 11 to 15 diseased spots on each leaf; level 4 with 16 to 20 diseased spots on each leaf; level 5 with more than 20 diseased spots on each leaf; tested in 2018 May in Jiaxing City, Zhejiang Province. The test agents are 33% copper quinoline SC (produced by Zhejiang Hisun Chemical Co., Ltd.), 20% thiazole zinc SC (produced by Zhejiang Xinnong Chemical Co., Ltd.), and 30% calcium quinoline SC (Jiaxing Shicheng Trading Co., Ltd.). (Provided), once in the early stages of peach bacterial perforation.

Field tests show that: in the early stages of peach tree bacterial perforation, 30% quinoline calcium 1000 times SC, 33% quinoline copper SC 1000 times, and 20% thiazole zinc SC 1000 times all have better control of the disease. The difference between the agents is not obvious; 30% quinoline calcium SC is 100 times harmless to the peach tree and the control effect is significantly better than other treatments. The results are shown in Table 10 below.

Table 10: Control effect of antibacterial agent on peach tree bacterial perforation

At the same time, the safety of calcium quinoline and copper quinoline on peach trees was observed. It was found that copper quinoline had slight phytotoxic effects on the young leaves of peach trees, especially the peach leaves in flowering period had phytotoxic effects, but quinoline calcium did not. Any phytotoxic effects.

Field test example 5: control of tomato late blight

Test method: The field efficacy test was carried out in accordance with the Ministry of Agriculture's pesticide field efficacy test guidelines (I) (fungicide control guidelines for the prevention and cure of rice leaf diseases). The test was conducted in May 2017 in Jiaxing, Zhejiang. The test agents were 33% quinoline copper SC (produced by Zhejiang Hisun Chemical Co., Ltd.), 75% mancozeb WP (produced by Dow AgroSciences, USA), and 40% quinoline calcium SC (Jiaxing Shicheng Trading Co., Ltd. (Provided by the company), with a water spray volume of 675 kg per hectare.

Field tests showed that for tomato late blight, 40% quinoline calcium SC1200 and 2000-fold solution were significantly better than 33% quinoline copper SC 1500-fold and 1000-fold solution, but the above agents were better than 75% mancozeb WP800-fold solution. The specific results are shown in Table 11 below.

Table 11: Antibacterial effect on tomato late blight

Since the test garden is a greenhouse for long-term cultivation of eggplant fruits, tomato umbilical rot occurred during the test in the shed. We conducted a survey at the same time. Umbilical rot was caused by imbalance of water supply, calcium and boron deficiency. Physiological diseases. From the results of the following investigations, the use of 40% quinoline calcium SC foliar spray in the early stages of young tomato fruits can effectively prevent the occurrence of umbilical rot, indicating that calcium ions can be absorbed by leaves or young fruits, thereby effectively controlling The occurrence of the disease. The specific results are shown in Table 12 below.

Table 12: Control effect of antibacterial agents on tomato umbilical rot

Formulation example:

Formulation Example 1:

96% quinoline calcium powder 10.4%, acrylic acid homopolymer sodium salt 2%, alkylphenol polyoxyethylene ether carboxylate 6%, fatty alcohol polyoxyethylene ether 4%, alginic acid 2%, xanthan Glue 1%, organosilicone 1%, water supplemented to 100%, put into the sand mill for sanding for 60min, and then filter through secondary sanding in series to obtain 10% SC of quinoline calcium.

Formulation Example 2:

96% quinoline calcium original powder 20.8%, acrylic acid homopolymer sodium salt 2%, alkylphenol polyoxyethylene ether carboxylate 6%, fatty alcohol polyoxyethylene ether 4%, alginic acid 2%, xanthan Glue 1%, organosilicone 1%, water supplemented to 100%, put into the sand mill for sanding for 60min, and then filter through two stages of sand grinding in series to obtain 20% SC of quinoline calcium.

Formulation Example 3:

96% quinoline calcium powder 41.7%, ethylene glycol 2%, dimethyl polysilane 0.1%, xanthan gum 0.3%, naphthalenesulfonic acid condensate sodium salt 3%, polyoxyethylene nonylphenol phosphate The sodium salt was supplemented with 1% water to 100%, put into a sand mill for 60 min, and then filtered through a two-stage series sand mill to obtain 40% SC of quinoline calcium.

Formulation Example 4:

96% quinoline calcium powder 62.5%, ethylene glycol 3%, dimethyl polysilane 0.1%, xanthan gum 0.2%, naphthalenesulfonic acid condensate sodium salt 4%, polyoxyethylene nonylphenol phosphate The sodium salt was supplemented with 1% water to 100%, put into a sand mill for sanding for 60 min, and then filtered through a secondary sand mill in series to obtain 60% SC of quinoline calcium.

Formulation Example 5:

96% of original quinoline calcium powder 62.5%, maleic acid-acrylic acid copolymer sodium salt 6%, beef tallow ethoxyamine salt 2%, sodium dibutylnaphthalenesulfonate 5%, sodium carboxymethyl starch 10 %, Attapulgite 10%, white carbon black supplemented to 100%, put into a blender and stir well, then pulverize by air flow to obtain calcium quinoline master powder; dissolve 2% gum arabic and 2% polyvinyl alcohol in water Into an easy-flowing aqueous solution; in the state of stirring the mother powder, spray the entire aqueous solution into the mother powder and mix to form a wet material, wherein the water content is 10-30% by weight of the dry matter; the wet material is granulated and dried by extrusion , The whole granules, to obtain calcium quinoline 60% WDG.

Formulation Example 6:

96% quinoline calcium powder 50.1%, maleic acid-acrylic acid copolymer sodium 3%, polycondensation naphthalenesulfonate 3%, alkylnaphthalenesulfonate 2%, attapulgite 3%, lauryl sulfuric acid Sodium 4% and kaolin were replenished to 100%, put into a blender and stirred uniformly, and then pulverized by air flow to obtain 50% WP of quinoline calcium.

Claims (12)

1. The use of a compound having the following chemical formula A for plant disease control, the chemical formula of the compound having the chemical formula A is as follows:

   

   The plant disease is one or more of a plant fungal disease, a plant bacterial disease or a plant deficiency caused by calcium deficiency.
2. The use according to claim 1, characterized in that the plant disease is a plant fungal disease and a plant nutrition deficiency caused by calcium deficiency.
3. The use according to claim 1, characterized in that the plant disease is a plant bacterial disease and a plant nutrition deficiency caused by calcium deficiency.
4. The use according to any one of claims 1 to 3, characterized in that the plant is a crop selected from the group consisting of cereals, fruit trees, vegetables, sugar plants, oil crops, tobacco or tea trees Of any crop.
5. The use according to any one of claims 1 to 3, characterized in that the plant diseases are rice leaf blight, rice base rot, cucumber keratosis, early tomato blight, bacterial stripe of rice, tomato Late blight, apple spotted leaf disease, grape downy mildew, or peach bacterial perforation.
6. The use according to any one of claims 1-3, characterized in that the effective amount of the compound having the formula A for controlling plant diseases is 15-1500 g / ha, preferably, the effective amount of the compound having the formula A for controlling plant diseases is 100-500g / ha.
7. A pharmaceutical composition for controlling plant diseases, said composition comprising a compound having the following chemical formula A and an agricultural, forestry or sanitary acceptable adjuvant and a carrier,

   

   Wherein, the weight of the compound having the chemical formula A accounts for 1-99% of the weight of the pharmaceutical composition, and the sum of the weight of the adjuvant and the carrier accounts for 1-99% of the weight of the pharmaceutical composition.
8. The pharmaceutical composition for controlling plant diseases according to claim 7, wherein the dosage form of the pharmaceutical composition is a suspension, a suspension emulsion, a water-dispersible granule, or a wettable powder.
9. The use of the pharmaceutical composition according to any one of claims 7 to 8 for controlling plant diseases, characterized in that the plant disease is one or more of a plant fungal disease, a plant bacterial disease, or a plant auxotrophic disease Species.
10. The use according to claim 9, characterized in that the weight content of the compound having the chemical formula A in the pharmaceutical composition is 20-60%, and the dilution factor is 100-4000 times when it is applied.
11. The use according to claim 9, characterized in that the plant disease is rice leaf blight, rice base rot, cucumber keratosis, early tomato blight, bacterial stripe or late blight of tomato.
12. A method for controlling plant diseases by applying the pharmaceutical composition according to claim 7 or 8, characterized in that the pharmaceutical composition is applied to the plant of the disease to be controlled at an effective dose of 15 to 1500 grams of quinoline calcium per hectare or needs to be controlled. On a medium for controlling harmful bacteria or fungi, preferably, the pharmaceutical composition is applied at an effective dose of 100 to 500 grams of calcium quinoline per hectare to a plant to be controlled for a disease or a medium for controlling harmful bacteria or fungi. .