WO2019206466A1

WO2019206466A1 - Antiperspirant preparation comprising alkaline earth metal salts and carboxylic acids

Info

Publication number: WO2019206466A1
Application number: PCT/EP2019/051050
Authority: WO
Inventors: Dorothea Schweiger; Annika Patricia RING; Clare VICKERS; Lätitia Neumann; Robert Klauck; Frank Lehmbeck; Elke Grotheer
Original assignee: Beiersdorf Ag
Priority date: 2018-04-27
Filing date: 2019-01-16
Publication date: 2019-10-31
Also published as: AU2019259299A1; DE102018206624A1; EP3784203A1; BR112020018031A2

Abstract

The invention relates to a combination of one or more alkaline earth metal salts and one or more carboxylic acids in cosmetic or dermatological preparations, with a pH-value of less than 5, demonstrating a synergistic antiperspirant effect. The combination can consist of at least two preparations, one preparation containing the carboxylic acid and the other preparation containing the soluble alkaline earth metal salts.

Description

description

Antiperspirant active preparation comprising alkaline earth metal salts and carboxylic acids

The invention is a combination of one or more alkaline earth metal salts and one or more carboxylic acids in cosmetic or dermatological formulations having a pH of less than 5.

Also according to the invention is a combination of at least two preparations, one preparation comprising the carboxylic acid and the other preparation comprising the soluble alkaline earth metal salts.

As sweat becomes one of the skin of humans over so-called sweat glands

designated secreted aqueous secretion. There are three types of sweat glands in the skin, namely, apocrine, eccrine, and apoekrine sweat glands (Int J Cosmet Sei. 2007 Jun;

29 (3): 169-79).

The eccrine sweat glands in humans are distributed practically throughout the body and can produce significant amounts of a clear, odorless secretion that is over 99% water. In contrast, the apocrine sweat glands occur only in the hairy body areas of the armpit and genital region and on the nipples. They produce small amounts of a milky secretion that contains proteins and lipids and is chemically neutral.

Sweating, also known as transpiration, is an effective mechanism to release excess heat and thereby regulate body temperature. The volume-rich aqueous secretion of the eccrine glands, which can produce up to 2-4 liters per hour or 10-14 liters a day in adults, is used for this purpose.

The sweat - especially the secretion of apocrine sweat glands - is also signaled by the sense of smell. In humans, the apocrine sweat plays in particular in connection with the emotional or stress related

Sweating matter.

Cosmetic antiperspirants or deodorants / deodorants are used to eliminate body odor or to reduce their formation. Body odor arises when the per se odorless fresh sweat by microorganisms such. Staphylococci and

Corynebacteria is decomposed. The usual cosmetic deodorants are based on different active principles.

In general parlance is not always a clear separation of concepts

"Deodorant" and "antiperspirant". Rather, especially for German-speaking countries, products for use in the armpit area are referred to as deodorants or "deodorants". This is irrelevant to the question of whether an antiperspirant effect is present.

Antiperspirants (AT) are antiperspirants which, in contrast to the deodorants which generally prevent microbial decomposition of already formed perspiration, are said to prevent the secretion of sweat at all.

In addition to the actual antiperspirant active ingredients (AT-agents), AT preparations may additionally contain substances which inhibit the microbial degradation of the perspiration, such as, for example, Triclosan. Triclosan has an effect against gram-positive and gram-negative bacteria as well as against fungi and yeasts, which results in a deodorizing, but no antiperspirant effect, as no influence on the sweat secretion can be deduced from the influence on the bacterial skin flora.

In contrast to the antiperspirants pure deodorants cause no active

Influencing the sweat secretion, but only the control or influence of the body or armpit odor (odor control agent). Common mechanisms of action for this are antibacterial effects, such as e.g. also shows the non-colloidal silver,

Odor neutralization (masking), influencing of bacterial metabolisms, the pure perfuming as well as the use of precursors of certain perfume components, which are converted by enzymatic reactions to fragrant substances.

The effect of antiperspirants based on Al salts against thermal sweating under normal physiological conditions has been well studied.

It is believed that the sweat reduction in aluminum-containing

Antiperspirant active agents, etc. achieved by a "blockage of the sweat gland". They work by blocking sweat gland excretions by precipitating them together with the skin's own proteins, leading to so-called plugs.

Whether this obstruction by denaturation of keratin or by clumping of

Corneocytes in the sweat duct (Shelley WB and Hurley HJ, Acta, Derm. Venereol. (1975) 55: 241-60), or by the formation of an ACH / AZG gel (Reller HH and Luedders WL, in: Advances in Modern Hemisphere Publishing Company, Washington and London (1977) Vol. 4: 1-5), which is formed by neutralization in the sweat gland duct, remains open. The thus obtained and known constipation is effective only in the short term. strong

Sweating or armpit cleaning as part of the normal body cleansing routine relieve the constipation and thus the antiperspirant effect. However, the resulting need to apply antiperspirant (AT) products at least once a day may cause skin irritation, especially after shaving or in or on previously damaged areas of the skin.

In WO 2007071474 A1 it is also described that the axillary administration of aluminum-containing antiperspirants, preferably ACH, in deo / AT formulations by adding small amounts of organic solvent to a greatly increased

Keratinization rate of the cells of the sweat gland duct. As a result, more horny corneocytes are released, which are released into the duct as part of the natural desquamation, clogging the duct from the inside and preventing the flow of sweat. This additional obstruction mechanism is insensitive to increased sweating and / or cleansing and thus provides an additional long-term antiperspirant (AT) effect.

It is reported in the literature that calcium and magnesium salts are not effective

Antiperspirant drugs are (Reller, Lüdders, Pharmacologic and Toxicological Effects of Topically Applied Agents on the eccrine sweat glands, Vol 4, p 18, 1975).

However, WO 2013013999 A2 describes the antiperspirant activity (sweat reduction) of alkaline earth metal salts. Compounds of polyvalent cations, such as beryllium, magnesium, calcium, strontium, barium, titanium, manganese, zinc, hafnium and aluminum, with anions from the group of the halides and carboxylic acids are listed as being AT-active and only the salts acetate, propionate , Pyrrolidonecarboxylate,

Sorbate, gluconate, ascorbate, pantothenate, citrate, lactate, aspartate, glutamate, bicarbonate or nitrate.

In DE 102014222270 A1 aluminum salt-free antiperspirant compositions are described. The AT effect should be based on the use of hydroxycarboxylic acids or their salts. As possible hydroxy acids u.a. Citric acid, malic acid, gallic acid and tartaric acid.

DE 102005012476 A1 describes the use of selected C2-C12 carboxylic acids and their metal salts as the substances that inhibit the formation of body odors. An antiperspirant effect is achieved only by the addition of conventional aluminum salts.

DE 102015226630 A1 discloses silica in a 2-chamber packing agent for

Sweat reduction. Carboxylic acids such as tartaric acid or lactic acid are used herein described as buffer substances. The pH of the silica-containing preparations is preferably from 5.1 to 6.9.

It is desirable to provide novel antiperspirant preparations which do not have the disadvantages of the known AT-active preparations. In particular, it is desirable to provide alternative AT preparations which do not

Include aluminum salts.

In some studies of the prior art, the cosmetically usable alkali and alkaline earth metal salts mentioned there have a sweat-reducing effect. The

Investigations under laboratory conditions do not always reflect the everyday use of cosmetic antiperspirants.

In addition, the consumer expects a sweat inhibition that lasts at least one working day.

It is therefore desirable to provide a cosmetic formulation which, in addition to effective odor reduction, reduces the amount of sweat in the armpit for at least 24 hours and is free from aluminum salts.

The invention is a cosmetic or dermatological hydrous and / or alcoholic preparation comprising one or more alkaline earth metal salts and one or more

Carboxylic acids.

The alkaline earth metal salts added to the preparation are water-soluble.

The pH of the preparation is adjusted to a value of less than 5, in particular in the range of 4.5 and smaller.

The preparation of the invention is antiperspirant active without further

antiperspirant substances, in particular aluminum salts, are present.

The use of the antiperspirant preparations according to the invention and as antiperspirants is also part of the present invention.

The preparations according to the invention are used for reducing sweat primarily in the armpit. In addition, the formulations can also be used to reduce the sweat flow on other body areas where consumers sweat undesirable. This may be, but is not limited to, the feet, the forehead, the palms or the back. Due to the advantageous freedom of aluminum, the

Preparations according to the invention also easily sensitive to these

Apply skin areas. The formulations are applied in a form that is acceptable to the consumer, which can be advantageous, for example, pump sprays, sprays with aerosols, ball applicators, pens, tubes, soft-touch applicators, capsules.

As detailed investigations show, the inventive antiperspirant effect of the combination of alkaline earth salts and carboxylic acids based on the following mechanisms explained in more detail, but without being bound to this theory.

It is known that numerous salts of the carboxylic acids according to the invention in water or alcohol (ethanol) are sparingly soluble and therefore in a water-containing, alcoholic

Be precipitated, such as alkaline earth metal soaps of fatty acids

Stearic acid, palmitic acid or oleic acid. Thus, magnesium or calcium stearate are almost insoluble in water or ethanol. Therefore, it seems problematic to provide the alkaline earth salts with the carboxylic acids in a water-containing or alcoholic preparation.

A common preparation of cosmetic preparations are emulsions.

Alkaline earth metal salts such as magnesium stearate are known in cosmetic preparations. For example, magnesium stearate can be used to increase the consistency in oil phases of

Emulsions are used. A typical example is the well-known Nivea cream.

These conventional cosmetic formulations have a pH which is higher than the pKa of fatty acids. Thus, alkaline earth metal salts, such as the chlorides, and the anion of the fatty acid form the alkaline earth metal salt of the fatty acid, which is only soluble in the oil phase, and which then greatly increases the viscosity.

It was therefore the goal that the sparingly soluble alkaline earth metal salts do not form in the preparation.

According to the invention, the sparingly soluble alkaline earth metal salts of carboxylic acids are not added directly to the difference in the prior art, but soluble

Alkaline earth metal salts, such as magnesium chloride, are introduced in the water phase and the carboxylic acids in the oil phase and the pH is adjusted below 5. In emulsions comprising one or more water or oil phases, the water-soluble alkaline earth salts, such as magnesium chloride, in the water phase and the carboxylic acid, such as, for example, stearic acid, and dissociated in the oil phase are present.

For if the pH value of the formulations is set clearly above the pKa value of the fatty acid, the salt of the fatty acid is already formed in the preparation, and so does the Viscosity strong, which in turn is known as a strong thickener for oil phases, which should be avoided.

Therefore, the pH of the preparation is set in the range of less than 5, especially less than 4.5, and surprisingly no precipitation of the poorly soluble magnesium fatty acid salt is observed. In an emulsion are the two

Components according to the invention in different phases and can be applied together to the skin.

If the preparation according to the invention is then applied to the skin, due to the skin pH range from 5 to 7, the pH of the preparation applied to the skin is in the range of greater than 4 or greater a precipitate of the sparingly soluble alkaline earth metal fatty acid salts, such as Magnesium stearate, observed.

By the application of the preparation according to the invention to the skin are formed

Alkaline earth precipitates, which precipitate in sweat gland ducts, causing constriction or blockage, thereby inhibiting perspiration.

Due to the increase in pH after distribution on the skin, the step of deprotonation of the acid which causes precipitate formation occurs. The formulation contains stearic acid, which, as soon as the product is applied to the skin, dissociates and together with the magnesium chloride forms the insoluble magnesium stearate, which is ultimately responsible for the sweat reduction.

Thus, a preferred emulsion preparation with magnesium chloride and stearic acid and a pH of 4.0 showed an extremely good antiperspirant effect.

It is therefore advantageous that the preparation of the invention has a pH of less than 5, preferably between 3.5 and 4.5, in particular in the range of 3.8 to 4.2, so that the preparation stored without precipitation and ready for application Available.

For the pH adjustment of preparations, the expert is familiar with numerous possibilities. In particular, the addition of the carboxylic acids allows and already produces a pH in the preferred range.

The low pH value according to the invention was surprisingly also advantageous with respect to the consistency of the preparation.

According to the invention, it is also a combination of at least cosmetic or dermatological preparations to provide, wherein in one preparation, the carboxylic acids and in another preparation, the alkaline earth metal salts are included. The application and use of these preparations is then advantageously in a 2-step application or from a 2-chamber packaging.

Here, in a first step, a preparation may be applied to the skin comprising the carboxylic acid, such as stearic acid.

In step 2, a preparation comprising the alkaline earth metal salt such as MgC is applied.

When the two preparations on the skin meet the forming

Magnesium stearate and leads to the described sweat reduction due to the pore narrowing by the forming precipitates.

The application steps described above can also be carried out in reverse order or multiple times.

It is likewise according to the invention if the two preparations in which one comprises the carboxylic acid and the other the alkaline earth metal salt are applied from a 2-chamber packaging agent. This results in a mixture of the two substances, carboxylic acid and salt, directly before application and can thus, as stated, lead to a reduction in sweat on the skin.

According to the invention, a distinction is made between the two types of alkaline earth metal salts. The water-soluble alkaline earth metal salts, such as the preferred magnesium, calcium and strontium halides, are added to the formulation.

Only after application to the skin are the sparingly soluble alkaline earth metal salts of the fatty acids, such as, for example, magnesium, calcium or strontium stearate, palmitate, myristate, or oleate. The latter, the salts referred to as sparingly soluble alkaline earth metal salts, are not to be understood as those salts which are known as soluble alkaline earth metal salts of the

Preparation be added from the outset. Only the last-mentioned sparingly soluble salts form the precipitations on the skin which are known as precipitates and which are responsible for the AT action. Formulations comprising water-soluble salts alone do not show the effect and precipitate formation. Preparations comprising only the sparingly soluble alkaline earth metal salts, in turn, do not have an antiperspirant effect since the sparingly soluble salts are not available for precipitate formation on the skin.

Therefore, according to the invention, a method for the formation and / or deposition of

Alkaline earth metal precipitates on the skin leading to blockage or narrowing of

Sweat glands lead. This is achieved by the application of a preparation according to the invention to the skin and an thereby occurring pH value of the preparation on the skin, which leads to the formation of the alkaline earth metal precipitates. As stated above, a method according to the invention also comprises the sequence of

Application first of a preparation comprising carboxylic acid or soluble

Alkaline earth metal salts and then or at the same time the application of a second preparation to the same site of the skin then comprising each of the previous preparation not present carboxylic acid or soluble alkaline earth metal salts.

Again, the formation and / or deposition of alkaline earth metal precipitates on the skin, which leads to a blockage or constriction of sweat glands and thus one takes place

causes antiperspirant effect.

The following investigations show that a method characterized by

Application of a preparation according to the invention on the skin, antiperspirant acts.

Likewise, therefore, a preferably non-therapeutic antiperspirant process according to the invention, which is characterized by the application of a preparation to the skin, if the preparation comprises at least water, or alcohol, a carboxylic acid and a water-soluble alkaline earth metal salt and the preparation thereby has a pH of less than 5 having.

Preferred methods are non-therapeutic methods, cosmetic methods that lead to cosmetic sweat reduction or inhibition.

In particular, the processes are preferred in which, as alkaline earth metal salts, magnesium or calcium chlorides and as carboxylic acids one or more acids selected from adipic acid, arachidic acid, lauric acid, myristic acid, caprylic acid, capric acid, oleic acid, plamitic acid, behenic acid, linolenic acid, stearic acid and / or tartaric acid , in particular stearic acid and palmitic acid.

The preparations according to the invention can be prepared, for example, as follows.

The water phase and fat phase are heated and combined with stirring. Subsequently, the emulsion is cooled down with stirring and the active substance phase, the soluble

Alkaline earth metal salts, such as magnesium chloride, added to the emulsion at 30 ° C. Finally, the approach is homogenized.

Comparative experiments were carried out which represent the precipitation and precipitate formation under laboratory conditions and confirm the sweat reduction.

For this purpose, combinations of alkaline earth metal salt and carboxylic acid were dissolved in

presented various solvents at a pH of 3.5. Other ingredients were initially omitted to avoid interference.

Subsequently, the pH of the solutions was slowly increased with NaOH (1 mol / L). At pH ranges of 4.2 up to 5 then precipitations occurred. These laboratory tests make the effect on the skin easy to represent, since the skin has a pH of about 5 to 7, so also takes place an increase in pH when applying and distributing the preparation on the skin and it precipitates and thus precipitate formation in the sweat gland.

The table below shows the test results:

Preferred carboxylic acids according to the invention are one or more acids selected from the group consisting of adipic acid, arachidic acid, succinic acid, lauric acid, maleic acid, malonic acid, myristic acid, oleic acid, palmitic acid, stearic acid and / or tartaric acid. Preferably, a mixture of several of these acids is to be selected, in particular a mixture comprising palmitic acid, stearic acid, myristic acid, oleic acid and arachidic acid.

As alkaline earth salts are preferably used magnesium, calcium and

Strontium halides, in particular magnesium chloride and its hydrates, in particular hydrates to MgCl ₂ ^* 6H ₂ Ö, in particular MgCl ₂ ^* 6H ₂ Ö, and / or calcium chloride, and

Magnesium phosphate.

The preparations according to the invention differ from prior art formulations comprising alkaline earth metal salts of the cited carboxylic acids, such as magnesium stearate, solely in that the two substances essential to the invention, water-soluble alkaline earth metal salt and carboxylic acid are present separately from one another.

Preparations comprising alkaline earth salts of the acids adipic acid, arachidic acid, succinic acid, lauric acid, maleic acid, malonic acid, myristic acid, oleic acid, palmitic acid, stearic acid and / or tartaric acid are therefore not according to the invention.

Likewise, the preparations according to the invention are antiperspirant active, antiperspirant preparations solely from the inventive combination of water-soluble alkaline earth metal salt, carboxylic acid and pH below 5. Also here

The preparations according to the invention differ from prior art preparations containing another AT active ingredient.

Antiperspirant active cosmetic or dermatological preparations are preferred according to the invention

one or more alkaline earth metal salts selected from the group of magnesium and calcium halides, in particular magnesium and calcium chloride, are preferred

MgCl ₂ ^* 6H ₂ 0,

one or more carboxylic acids selected from adipic acid, arachidic acid, lauric acid, myristic acid, caprylic acid, capric acid, oleic acid, plamitic acid,

Behenic acid, linolenic acid, stearic acid and / or tartaric acid, in particular

Stearic acid and palmitic acid, and

Water and / or ethanol wherein the pH of the preparation in the range of 3 to 5, in particular in the range of 3.5 to 4.5, preferably in the range of 3.8 to 4.2, is selected.

The proportion of one or more alkaline earth salts is preferably selected in the range from 5 to 20% by weight, in particular in the range from 7 to 10% by weight, based on the total mass of the preparation.

The proportion of one or more carboxylic acids is advantageously selected in the range from 1 to 5% by weight, in particular in the range from 2 to 4, based on the total mass of the preparation.

Apart from the alkaline earth salts and carboxylic acids, no further advantages are advantageous

antiperspirant active substances, in particular no aluminum salts such as

Aluminiumchlorohydrate added to the preparations of the invention.

The addition of further antiperspirant, antiperspirant substances is therefore advantageously less than 0.1 wt.%, In particular at 0 wt.%, Based on the total mass of the preparation to refer by introduction or impurities and these as free of additional AT-active ingredients ,

Preparations according to the invention are preferably O / W emulsions, W / O emulsions, aqueous-alcoholic preparations, alcoholic (ethanolic) solutions, PIT emulsions or hydrodispersions.

The results shown were particularly advantageous for both micro- and macroemulsions as well as aqueous-alcoholic and purely alcoholic formulations.

As alcoholic formulations according to the invention ethanolic solutions are used.

Advantageously, the preparations according to the invention comprise one or more lipids.

Preferably used lipids are selected from the group of Capric / Caprylic

Triglyceride, cocoglyceride, PPG-14 butyl ether, PPG-9 butyl ether, PPG-12 butyl ether, PPG-14 butyl ether, PPG-15 butyl ether, PPG-16 butyl ether, PPG-17 butyl ether, PPG-18 butyl ether, PPG-2 butyl ether, PPG -20 butyl ether, PPG-22 butyl ether, PPG-24 butyl ether, PPG-26

Butyl ether, PPG-30 butyl ether, PPG-33 butyl ether, PPG-40 butyl ether, PPG-52 butyl ether, PPG-53 butyl ether, PPG-15 stearyl ether, coco-caprylates / caprate, dicaprylyl ether,

Octyldodecanol, Paraffinum Liquidum, Isododecane, Isopropyl Palmitate, Persea Gratissima, Caprylyl Carbonate, Helianthus Annuus, Ethylhexyl Cocoate, C12-15 Alkyl Benzoate,

Cyclomethicones and / or dimethicones, phenyltrimethicone, sunflower oil, rapeseed oil,

Capric / Caprylic Triglyceride, Isopropyl Myristate, Isopropyl Palmitate, Isopropyl Stearate, Cetearyl Ethylhexanoate, Hydrogenated Polydecene, Glycine Soybean Oil, Olive Oil, Guerbet Alcohols such as hexyldecanol, octyldodecanol and 2-ethylhexylalcohol. also Guerbet alcohol esters, and mixtures of Guerbet alcohols and Guerbetalkoholestem, such as hexyldecanol and hexyldecyl laurate.

As an emulsion, the preparations according to the invention are advantageously one or more

Emulsifiers from the group of nonionic emulsifiers, such as, for example, propylene glycol isostearate (HLB 2.5), glycol stearate (HLB 2.9), glyceryl isostearate (HLB 3.5),

Sorbitan sesquioleate (HLB 3.7), glyceryl stearate (HLB 3.8), lecithin (HLB 4), sorbitan oleate (HLB 4.3), sorbitan monostearate NF (HLB 4.7), sorbitan stearate (HLB 4.7), sorbitan

Isostearates (HLB 4.7), steareth-2 (HLB 4.9), oleth-2 (HLB 4.9), glyceryl laurate (HLB 5.2), ceteth-2 (HLB 5.3), PEG-30 dipolyhydroxystearates (HLB 5.5), glyceryl stearate SE ( HLB 5.8), Sorbitan Stearate (and) Sucrose Cocoate (HLB 6), PEG-4 Dilaurate (HLB 6), PEG-8 Dioleate (HLB 8), Sorbitan Laurate (HLB 8.6), PEG-40 Sorbitan Peroleate (HLB 9) , Laureth-4 (HLB 9.7), PEG-7 Glyceryl Cocoate (HLB 10), PEG-20 Almond Glycerides (HLB 10), PEG-25

Hydrogenated Castor Oil (HLB 10.8), Stearamide MEA (HLB 11), Glyceryl Stearate (and) PEG-100 Stearate (HLB 11), Polysorbate 85 (HLB 11), PEG-7 Olivate (HLB 11), Cetearyl Glucoside (HLB 11 ), PEG-8 oleate (HLB 11.6), polyglyceryl-3-methylglucose distearate (HLB 12), PG-10 stearate (HLB 12), oleth-10 (HLB 12.4), oleth-10 / polyoxyl 10 oleyl ether NF (HLB 12.4 ), Ceteth-10 (HLB 12.9), PEG-8 Laurate (HLB 13), Ceteareth-12 (HLB 13.5), Cocamide MEA (HLB 13.5), Polysorbate 60 NF (HLB 14.9), Polysorbate 60 (HLB 14.9) , PEG-40 Hydrogenated Castor Oil (HLB 15), Polysorbate 80 (HLB 15), isosteareth-20 (HLB 15), PEG-60 Almond Glycerides (HLB 15), Polysorbate 80 NF (HLB 15), PEG-150 Laurate, PEG-20 methyl glucose sesquistearate (HLB 15), ceteareth-20 (HLB 15.2), oleth-20 (HLB 15.3), steareth-20 (HLB 15.3), steareth-21 (HLB 15.5), ceteth-20 (HLB 15.7) , Isoceteth-20 (HLB 15.7), PEG-30 Glyceryl Laurate (HLB 16), Polysorbate 20 (HLB 16.7), Polysorbate 20 NF (HLB 16.7), Laureth-23 (HLB 16.9), PEG-100 S tearate (HLB 18.8), steareth-100 (HLB 18.8), PEG-80 sorbitan laurate (HLB 19.1).

The emulsions of the invention may also contain anionic or cationic emulsifiers. Preferred suitable cationic emulsifiers are selected from the group Cetrimonium Chloride, Palmitamidopropyltrimonium Chloride, Quaternium-87, Behentrimonium Chloride, Distearoylethyl Dimonium Chloride, Distearyldimonium Chloride, Stearamidopropyl Dimethylamine and / or Behentrimonium Methosulfate.

To stabilize the emulsions, it may be beneficial to add texturizers or thickeners.

Examples of preferred rheology modifiers are natural organic polymers and their derivatives, gum arabic, karaya, tragacanth, locust bean gum, guar, pectin, agar, carrageenan, alginates, xanthan, starch and starch derivatives, cellulose and cellulose derivatives such as microcrystalline cellulose, methylcellulose, cellulose gum, hydroxyethyl cellulose, Hydroxylpropylcellulose, methylhydroxypropylcellulose, further inorganic gelling agents, such as silicates, eg bentonites, hectorites, colloidal silicic acid; in addition, synthetic thickeners such as polyvinyl alcohol and also ethoxylated compounds such as poloxamer, PEG-150 distearate, PEG-120 methyl glucose dioleate, PEG-9 dilaurates and fatty alcohols such as stearyl alcohol, cetyl alcohol and cetearyl alcohol.

Preferred are, for example, hydroxyethylcelluloses, hydroxypropylcellulose, hydroxypropyl methylcellulose, ethylcellulose, cellulose gum, xanthan gum, guar gum, gellan gum, polyquaternium-37, locust bean gum, hydroxyalkyl starch phosphates, and carrageenan.

The aqueous phase of the preparations according to the invention may advantageously contain customary cosmetic auxiliaries, for example alcohols, in particular those of low C number, such as isopropanol, diols or polyols of low C number and also their ethers, preferably

Propylene glycol, 2-methylpropane-1,3-diol, pentane-1,2-diol, hexane-1,2-diol, octane-1,2-diol, decane-1,2-diol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products, foam stabilizers, electrolytes, etc.

According to the invention, it is preferred if the preparation according to the invention is characterized in that the preparation is propylene glycol, butylene glycol, 2-methylpropane-1, 3-diol, 1, 2-pentanediol, 1, 2-hexanediol, 1, 2-octanediol and / or 1, 2-decanediol contains.

To stabilize the pH of the formulations, other acids and their buffer systems can be used with suitable alkalizing agents. Suitable acids may include citric acid, lactic acid, maleic acid, malonic acid, succinic acid,

Hydroxysuccinic acid (malic acid), fumaric acid, salicylic acid, etidronic acid, phosphoric acid, hydrochloric acid and sulfuric acid.

Suitable alkalizing agents for creating a buffer system, for example, sodium hydroxide, potassium hydroxide, ammonia, mono-, di- and trialkylamines and the

Hydroxyalkylamines, aminomethyl propanol (2-amino-2-methylpropan-1-ol), ethanolamine (2-aminoethanol), triethanolamine (2,2 ', 2 "-nitrilotriethanol) and tetrahydroxypropyl ethylenediamine (1,1', 1", 1 '"-Ethylendinitrilotetrapropan-2-ol).

To prove the surprising antiperspirant effect of the invention

Preparations were carried out the following investigations.

For the quantitative measurement of the AT-performance, the reduction of the axillary sweat quantity was determined gravimetrically. The study (was based on the FDA criteria (Antiperspirants Drug Products for Over-the-Counter Human Use; Final Monograph (2003) Federal Register Vol 68, No.1 10, Rules and Regulations, §350.60 Guidlines for Effectiveness Testing of Antiperspirant Drug Products).

The sweat-reducing effect of MgCh / strearic acid (Example: 9 in the example formulations) was determined against an untreated control area.

preconditioning

Before starting the study, a 3-week pre-conditioning was carried out to wash out any remaining antiperspirant products in the armpit. During this period, the subjects under the armpits were allowed to clean exclusively with perfume-free soap (Baktolin pH 5.5) and use an ACH-free deodorant until one week before the start of the study. A shave of the armpit took place 3 days before the start of the study.

Behavior during the study

The armpits were washed with perfume-free soap (Baktolin pH 5.5) for approx. 30 seconds per armpit before the 2nd, 3rd and 4th application. After the tO measurement, the subjects were allowed

Only use the perfume-free soap for showering, so that no further washing was necessary before the first application. The test samples were allied and randomized in a defined amount applied on one side. After each application followed by a 30-minute

Exposure time in standard climatic conditions.

During measurements in the hotroom, the subjects had to sit upright with their arms upright, as pads were placed in the armpits to determine the amount of sweat.

During the study days the subjects were forbidden to do sweaty sports, sauna sessions and solarium and swimming pool visits. During acclimation no caffeine was allowed to be consumed.

measurements

The measurements related to the left and right axilla of a subject. The 40-minute period of sweating became unbalanced, and the 2-minute 20-minute periods were followed by well-balanced pads that absorbed sweat during the period. The pads of the sweat phase were discarded. After the

Measuring phases took place the delivery of the pads in the appropriate plastic containers. By a gravimetric determination the sweat quantities of the measuring phases 1 and 2 for the left and right armpit were determined. The measurements in the hotroom took place under the climatic conditions

Conditions of 38 ° C (□ 1.0 ° C) and 38% r. H. (□ 5%).

A total of 29 subjects were evaluated. 25 of them showed a significant

sweat reduction In a direct comparison, the untreated armpit (100% sweat volume) was compared with the treated area.

The test was carried out both 8h and 24h after the last application.

After 8 h, only a sweat quantity of 79.1% was observed, so that a sweat reduction of 20.9% was measured by MgCl 2 / stearic acid. This sweat reduction is significant.

After 24 h, a residual amount of residual welding of 86.5% was found

Sweat reduction of 13.5% corresponds. This shit reduction is also significant.

This above all long-term AT effect was surprising and fulfills the stated task of providing a preparation with a sweat inhibition up to 24 hours.

It is therefore according to the invention the combination formed from one or more water-soluble alkaline earth metal salts and one or more carboxylic acids as antiperspirant

Use of active ingredient combination in a cosmetic or dermatological preparation.

The preparation comprises water and / or alcohol and has a pH of less than 5.

In order to simultaneously allow deodorizing effects in addition to an antiperspirant effect, one or more deodorizing agents are advantageously added to the preparations according to the invention.

These deodorizing agents may preferably be selected from cationic polymers, in particular Polyquaternium-16, Polyquaternium-7, Polyquaternium-6, Polyquaternium-11 and Polyquaternium 37, polyaminopropyl biguanide and epsilon-polylysine.

As deodorizing agents may also be advantageous octenidine hydrochloride,

Alexidine dihydrochloride, benzyl alcohol, benzalkonium chloride, cetyltrimethylammonium chloride, silver citrate, triclosan, ethylhexylglycerol, triethyl citrate, 2-butyloctanoic acid, methylphenylbutanol, phenoxyethanol, zinc ricinoleate, and other drugs that reduce the number of bacteria on the skin.

The preparations according to the invention therefore preferably also comprise one or more polyquaternium polymers.

According to the invention, polyquaternium polymers are selected from the group of polyquaternium-16 polymers and polyquaternium-6 polymers. These are in accordance with the invention Preparations in a proportion of 0, 1 to 10 wt.%, In particular in a proportion of 0, 15 to 5 wt.%, Based on the total mass of the preparation containing.

Preference is given to polyquaternium-16 polymers (3-methyl-1-vinylimidazolium chloride-1-vinyl-2-pyrrolidinone chlorides) are selected. According to the invention, the polyquaternium polymers used, and in particular PQ-16 polymers, have an additional antimicrobial activity.

In advantageous embodiments of the invention, in addition to the used

Polyquaternium polymers containing one or more other deodorant substances.

The cosmetic or dermatological preparations according to the invention may further contain cosmetic adjuvants and active ingredients, such as are usually present in such

Preparations are used, for. As agents, preservatives, preservatives, bactericides, lipids, substances for preventing foaming, dyes and

Color pigments, thickeners, moisturizing and / or moisturizing substances or other customary constituents of a cosmetic or dermatological formulation, such as polyols, polymers, foam stabilizers, organic solvents or silicone derivatives, if the additive has the required properties with respect to stability, pH values and AT effect not impaired or excluded.

The following examples are intended to illustrate the present invention without it

limit. All quantities, proportions and percentages are, unless otherwise stated, on the weight and the total amount or on the total weight of

Preparation related.

Examples

macroemulsion

Watery / alcoholic solution

microemulsion

Claims

claims

1. Cosmetic or dermatological antiperspirant active preparation comprising

- water and / or alcohol,

one or more water-soluble alkaline earth metal salts and

- one or more carboxylic acids

characterized in that the preparation has a pH of less than 5.

2. Preparation according to claim 1, characterized in that the pH in the range of 3.5 to 4.5, in particular in the range of 3.8 to 4.2, is selected.

3. Combination consisting of at least two cosmetic or dermatological

Preparations characterized in that a preparation one or more

Carboxylic acids and another preparation one or more water-soluble

Alkaline earth metal salts.

4. Preparation or combination according to one of the preceding claims characterized

in that as alkaline earth metal salts magnesium, calcium and / or

Strontium halides and / or magnesium phosphate can be selected.

5. Preparation or combination according to claim 4, characterized in that as

Alkaline earth metal salts calcium chloride and / or magnesium chloride and / or hydrates of magnesium chloride, in particular MgCl ₂ ^* 6H ₂ 0, are selected.

6. Preparation or combination according to one of the preceding claims characterized

in that adipic acid, arachidic acid, succinic acid, lauric acid, maleic acid, malonic acid, myristic acid, caprylic acid, capric acid, oleic acid, palmitic acid, behenic acid, linolenic acid, stearic acid and / or tartaric acid are selected as the carboxylic acid.

7. Preparation or combination according to one of the preceding claims characterized

in that the carboxylic acid used is palmitic acid, stearic acid, myristic acid, oleic acid and / or arachidic acid, in particular stearic acid and / or palmitic acid.

8. Preparation or combination according to one of the preceding claims characterized

characterized in that the proportion of one or more alkaline earth metal salts in the range of 5 to 20 wt.%, In particular in the range of 7 to 10 wt.% Is selected, based on the total mass of the preparation.

9. Preparation or combination according to one of the preceding claims, characterized in that the proportion of one or more carboxylic acids in the range of 1 to 5 wt.%, In particular in the range of 1, 5 to 4 wt.% Is selected, based on the total mass the preparation.

10. Preparation or combination according to one of the preceding claims characterized

in that the proportion of further antiperspirant active substances in the preparation is less than 0.1% by weight, in particular 0% by weight, based on the total mass of the preparation.

11. Preparation or combination according to one of the preceding claims characterized

characterized in that they are in the form of a micro-, macroemulsions, aqueous-alcoholic solution or alcoholic solution.

12. Preparation or combination according to one of the preceding claims characterized

in that additionally one or more deodorizing agents are contained.

13. Preparation or combination according to claim 12, characterized in that as

Deowirkstoff cationic polymers, in particular Polyquaternium-16, Polyquaternium-7, Polyquaternium-6, Polyquaternium-1 1, Polyquaternium 37, Polyaminopropylbiguanid and / or epsilon-polylysine, are selected.

14. Use of a combination formed from one or more water-soluble

Alkaline earth metal salts and one or more carboxylic acids as antiperspirant

Active substance combination in a cosmetic or dermatological preparation, characterized in that the preparation comprises water and / or alcohol and has a pH of less than e.

15. Use according to claim 14, characterized in that the pH in the range of 3.5 to 4.5, in particular in the range of 3.8 to 4.2, is selected.

16. Use according to claim 14 or 15, characterized in that as

Alkaline earth metal salts magnesium, calcium and / or strontium halides and / or magnesium phosphate can be selected.

17. Use according to one of claims 14 to 16, characterized in that as

18. Use according to one of claims 14 to 17, characterized in that as

Carboxylic acids adipic acid, arachidic acid, succinic acid, lauric acid, maleic acid, malonic acid, myristic acid, caprylic acid, capric acid, oleic acid, plamitic acid, behenic acid, Linolenic acid, stearic acid and / or tartaric acid, in particular stearic acid and / or palmitic acid.

19. Use according to one of claims 14 to 18, characterized in that the proportion of further antiperspirant active substances in the preparation is less than 0.1% by weight, in particular 0% by weight, based on the total mass of the preparation.

20. A process for the formation and / or deposition of alkaline earth metal precipitates on the skin characterized by the application of a preparation according to any one of claims 1 to 13 to the skin.

21. Non-therapeutic antiperspirant process characterized by

Application of a preparation according to one of Claims 1 to 13 to the skin.

22. Non-therapeutic antiperspirant process, characterized in that a preparation comprising carboxylic acid or water-soluble alkaline earth metal salts is applied to the skin and then or at the same time a second preparation is applied to the same site of the skin, this second preparation comprising a carboxylic acid, provided that the first Preparation comprises alkaline earth metal salts, or

Alkaline earth metal salts, provided that the first preparation comprises carboxylic acids.