WO2019192441A1 - 一种微孔雾化片 - Google Patents

一种微孔雾化片 Download PDF

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Publication number
WO2019192441A1
WO2019192441A1 PCT/CN2019/080905 CN2019080905W WO2019192441A1 WO 2019192441 A1 WO2019192441 A1 WO 2019192441A1 CN 2019080905 W CN2019080905 W CN 2019080905W WO 2019192441 A1 WO2019192441 A1 WO 2019192441A1
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Prior art keywords
microporous
atomization
vibration
surface roughness
sheet
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PCT/CN2019/080905
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English (en)
French (fr)
Inventor
曹立
张雪梅
胡刚
黄芳芳
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广东东阳光药业有限公司
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Application filed by 广东东阳光药业有限公司 filed Critical 广东东阳光药业有限公司
Priority to US16/981,577 priority Critical patent/US20210053085A1/en
Priority to JP2021503190A priority patent/JP2021520298A/ja
Priority to EP19781755.4A priority patent/EP3778035A4/en
Publication of WO2019192441A1 publication Critical patent/WO2019192441A1/zh

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0638—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers spray being produced by discharging the liquid or other fluent material through a plate comprising a plurality of orifices
    • B05B17/0646—Vibrating plates, i.e. plates being directly subjected to the vibrations, e.g. having a piezoelectric transducer attached thereto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution

Definitions

  • the invention relates to the field of liquid atomizing devices, and in particular to a microporous atomizing sheet.
  • the microporous atomized sheet is mainly composed of a piezoelectric ceramic sheet and a vibration piece attached to the ceramic sheet, and a piezoelectric wire and a vibration piece respectively lead to a wire, and during use, a voltage is applied to the atomized piece.
  • the piezoelectric ceramic piece vibrates, and the vibration piece is further driven to vibrate together.
  • a plurality of micropores of uniform size are distributed on the vibrating piece, and the liquid surface is continuously squeezed under the excitation of vibration. After reaching a certain frequency and amplitude, part of the liquid in contact with the vibrating piece is extruded through the micropores to form minute droplets, which are generated. Atomization.
  • microporous atomized tablets are important components of portable atomizers, and their performance directly affects the effect of aerosol administration.
  • one of the defects of the existing microporous atomization sheet is that the particle size distribution of the droplet after vibration atomization is too wide and not concentrated, so that the proportion of the drug reaching the lesion is decreased, and the proportion of the diffusion distribution to other non-focal areas is greatly improved.
  • the degree of utilization is low, and the curative effect is lowered. If the inhaled drug is a drug with a side effect such as a hormone, excessive drug enters the non-lesional area, resulting in an increase in side effects and serious injury to the patient's body.
  • the object of the present invention is to provide a microporous atomization sheet with good atomization effect, and to optimize the surface roughness of the microporous atomization sheet, so that the surface of the metal oscillation piece is more flat.
  • the microporous distribution obtained by the processing is more uniform, so that the particle size distribution of the droplets sprayed by the atomization is narrower, thereby realizing the atomization effect of the quantitative and pulmonary positioning administration.
  • a microporous atomization sheet comprising a vibration plate having a water immersion surface and a water surface, wherein the vibration plate is provided with a micropore region, and a plurality of atomization holes are distributed in the micropore region, and the back surface of the vibration plate
  • the surface roughness is less than 150 nm.
  • the uniformity of the particle size distribution of the atomized particles is inseparable from the uniformity of the atomizing holes, and the surface roughness of the vibrating piece has an important influence on the uniformity of the atomizing holes, it is necessary to ensure atomized particles after atomization.
  • the distribution quality of the particle size needs to control the surface roughness of the metal vibrating piece in the atomized sheet within a certain range.
  • the invention studies the surface roughness of the vibrating piece in the microporous atomized sheet, and reduces the surface roughness of the back surface of the vibrating piece to make the surface of the vibrating piece more flat, and when the atomizing hole is processed on the surface of the vibrating piece, the atomizing hole
  • the size can be distributed more evenly, so that the normal distribution of droplet size after atomization is narrower and the fog is more concentrated.
  • the vibrating piece does not distinguish between the submerged surface and the back surface before processing the atomizing hole, and the surface roughness of both sides is uniform.
  • the surface roughness of the vibrating piece does not change.
  • the uniformity of the atomization hole distribution changes, and the normal distribution of the droplet size changes after atomization, if only the water immersion surface is changed.
  • the surface roughness of the back surface is unchanged, and the uniformity of the atomization hole distribution is not affected, and the normal distribution of the droplet size after atomization is not affected.
  • the inventors have found through extensive research that when the surface roughness of the back surface of the vibrating piece is greater than 150 nm, the particle size distribution of the atomized particles is broad, although the particle diameter is mainly distributed within 1 to 10 ⁇ m, but still in the range of 25 to 350 ⁇ m. There is a certain degree of distribution; and when the surface roughness of the back surface of the vibrating piece is 150 nm, 100 nm, 50 nm, 10 nm (when the error does not exceed ⁇ 20%), the atomizer including the microporous atomizing sheet of the present invention is utilized.
  • the particle size distribution of the particles after atomization is normally distributed, the atomized particles are uniform and highly concentrated, and the proportion of atomized particles having a particle diameter of 1-10 ⁇ m is as high as 96% or more, which is in line with the demand for pulmonary administration. Thereby, the drug utilization rate can be greatly improved and the dose can be reduced.
  • the inventors believe that the atomization effect and material cost can be based on their own needs. In balance, a microporous atomized sheet having a suitable surface roughness is selected.
  • the surface roughness of the water immersion surface of the vibrating piece is the same as the surface roughness of the water surface. In other embodiments, the surface roughness of the water immersion surface of the vibrating piece is different from the surface roughness of the water surface.
  • the vibration piece is made of a metal or a polymer material.
  • the vibration surface of the vibrating piece has a surface roughness of 10 to 120 nm.
  • the vibration surface of the vibrating piece has a surface roughness of 20 to 110 nm.
  • the vibration surface of the vibrating piece has a surface roughness of 50 to 100 nm.
  • the atomizing hole has a bell mouth shape, and the two ends of the atomizing hole are respectively a water inlet end and a water outlet end, and the water inlet end has a diameter larger than a diameter of the water outlet end.
  • the water inlet end is located at one side of the water immersion surface
  • the water outlet end is located at one side of the water surface.
  • the microporous region is provided with a plurality of protrusions, and the atomization holes are located on the protrusions.
  • the microporous region is provided with a protrusion, which can effectively increase the contact area between the atomized sheet and the liquid, and simultaneously spray the particles passing through the atomizing hole in different directions, so that the atomization direction is more divergent, thereby effectively reducing the fog. Collisions and fusions between the particles result in an increase in particle size.
  • the use of this structure can effectively improve the efficiency of energy conversion, reduce power loss and reduce heat generation.
  • the water immersion surface and/or the water surface of the vibration piece are provided with an anticorrosive layer.
  • the vibrating piece can be separated from the liquid to avoid corrosion of the liquid, and the vibrating piece is protected.
  • the corrosion resistance of the atomized sheet is improved and the service life is prolonged.
  • the anticorrosive layer is a polymer glaze.
  • the polymer glaze has good acid and alkali resistance and good antiseptic effect.
  • the invention has the beneficial effects of providing a microporous atomized sheet, and by optimizing the surface roughness of the vibrating piece, the distribution of the atomizing holes in the vibrating piece is more uniform, thereby making the particle size distribution of the atomized ejected droplets more uniform.
  • Figure 1 is a schematic view of the structure of the present invention
  • Figure 2 is a cross-sectional view showing a microporous atomizing sheet in the first embodiment of the present invention
  • Figure 3 is a cross-sectional view showing a microporous atomization sheet according to a second embodiment of the present invention.
  • Figure 4 is a partial enlarged view of the portion A in Figure 3;
  • FIG. 5 is a particle size distribution diagram of the obtained microporous atomized sheet after atomization in the first embodiment of the present invention
  • FIG. 6 is a particle size distribution diagram of a microporous atomized sheet in the third embodiment of the present invention after atomization;
  • FIG. 7 is a particle size distribution diagram of a microporous atomized sheet in the fourth embodiment of the present invention after atomization;
  • Fig. 8 is a view showing the particle size distribution of the obtained microporous atomized sheet in the fifth embodiment of the present invention after atomization.
  • the vibrating piece 1 the hollow annular piezoelectric ceramic piece 2, the micropore zone 3, the atomizing hole 4, the wire 5, the water immersion surface 6, and the back water surface 7.
  • a microporous atomization sheet comprising a vibration piece 1 and a hollow annular piezoelectric ceramic piece 2 composited in the vibration center of the vibration piece 1, a vibration piece 1 and a hollow annular piezoelectric ceramic piece. 2 leads a lead 5 for transmitting an electrical signal.
  • a micropore region 3 is disposed on the vibrating piece 1 corresponding to the central circular hole position of the hollow annular piezoelectric ceramic sheet 2, and a plurality of atomizing holes 4 are distributed in the micropore region 3.
  • the vibrating piece 1 has a water immersion surface 6 and a back water surface 7.
  • the atomizing hole 4 has a bell mouth shape, and the two ends of the atomizing hole 4 are respectively a water inlet end and a water outlet end, wherein the diameter of the water inlet end is larger than the diameter of the water outlet end, and the water inlet
  • the diameter of the end is 66 microns
  • the diameter of the outlet end is 3 microns
  • the inlet end is connected to the submerged surface 6, and the outlet end is connected to the back surface 7.
  • the number of atomizing holes 4 is 3,000.
  • the surface roughness of the back surface 7 of the vibrating piece 1 is 10 nm.
  • the difference between this embodiment and the first embodiment is that the micro-hole region 3 is provided with a plurality of protrusions, and the atomization hole 4 is located on the protrusion.
  • the difference between this embodiment and the first embodiment is that the surface roughness of the back surface 7 of the vibrating piece 1 is 50 nm.
  • the difference between this embodiment and the first embodiment is that the surface roughness of the back surface 7 of the vibrating piece 1 is 100 nm.
  • the difference between this embodiment and the first embodiment is that the surface roughness of the back surface 7 of the vibrating piece 1 is 150 nm.
  • the difference between this embodiment and the first embodiment is that the water immersion surface 6 and/or the water surface 7 of the vibration piece 1 are provided with an anticorrosive layer.
  • the anti-corrosion layer is a polymer glaze.
  • Test method the microporous atomized sheets of the above embodiments are respectively placed in an atomizer, and an ultrasonic frequency is provided for the microporous atomized sheet, and the atomized sheet receives an electric signal, and the hollow annular piezoelectric ceramic
  • the sheet 2 generates mechanical vibration, and the mechanical vibration of the hollow annular piezoelectric ceramic sheet 2 causes the vibration sheet 1 to vibrate, and the liquid in contact with the vibration sheet 1 is ejected through the atomizing hole 4 during the vibration to form a mist.
  • the albuterol solution was atomized using the above-mentioned atomizer, and the particle size distribution of the atomized particles obtained after the atomization was tested using a particle size analyzer.
  • FIG. 5 shows a particle size distribution map after atomization using the microporous atomization sheet of Example 1
  • FIG. 6 shows atomization using the microporous atomization sheet of Example 3.
  • FIG. 7 shows a particle size distribution map after atomization using the microporous atomization sheet of Example 4;
  • FIG. 8 shows a microporous atomization sheet using Example 5.
  • Particle size distribution map after atomization It can be seen from FIG. 5-8 that when the surface roughness of the back surface 7 of the vibrating piece 1 is less than 150 nm, the particle size distribution after atomization by the microporous atomizing sheet of the above embodiment is concentrated, 96%. The above is concentrated in the range of 1 to 10 ⁇ m. It can be seen from the above that the microporous atomized sheet of the present invention can make the normal distribution of the droplet size of the droplets sprayed by the atomization narrower and more uniform, thereby realizing the atomization effect of quantitative positioning administration.

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Abstract

一种微孔雾化片，包括具有浸水面（6）和背水面（7）的震动片（1），所述震动片（1）上设置有微孔区（3），所述微孔区（3）内分布有多个雾化孔（4），所述震动片（1）的背水面（7）表面粗糙度小于150纳米，该微孔雾化片，通过优化震动片的表面粗糙度，使得震动片中的雾化孔分布更均匀，从而使雾化喷出的液滴粒径分布更窄更均一，实现量化定位给药的雾化效果。

Description

一种微孔雾化片 技术领域
本发明涉及液体雾化装置领域，尤其涉及一种微孔雾化片。
背景技术
现有技术中微孔雾化片主要由压电陶瓷片和贴覆在陶瓷片上的震动片组成，压电陶瓷片和震动片上分别引出一根导线，使用过程中，对雾化片施加电压，当激励电信号通过导线传递至压电陶瓷片后引起压电陶瓷片振动，进一步带动震动片一起振动。震动片上分布有大小均匀的若干微孔，在振动的激励下不断挤压液面，达到一定频率和振幅后，与震动片接触的部分液体通过微孔被挤出，形成微小的液滴，产生雾化。
在喷雾治疗领域中，微孔雾化片是便携式雾化器的重要部件，其性能的好坏直接影响了雾化给药的效果。然而现有微孔雾化片的一个缺陷是振动雾化后的液滴粒径分布过宽，不集中，使得药物到达病灶的比例下降，而扩散分布至其它非病灶区域的比例大大提高，药物利用度低，疗效下降，若吸入药物为激素等副作用较大的药物，过多的药物进入非病灶区导致副作用增强，对病人身体造成严重伤害。
基于上述情况，我们有必要设计一种能够解决上述问题的微孔雾化片。
发明内容
为解决现有技术中存在的问题，本发明的目的在于：提供一种雾化效果好的微孔雾化片，通过优化微孔雾化片的表面粗糙度，使得金属振荡片表面更加平整，加工得到的微孔分布更加均一，使得雾化喷出的液滴粒径分布更窄，从而实现量化、肺部定位给药的雾化效果。
为达此目的，本发明采用以下技术方案：
一种微孔雾化片，包括具有浸水面和背水面的震动片，所述震动片上设置有微孔区，所述微孔区内分布有多个雾化孔，所述震动片的背水面表面粗糙度小于150纳米。
具体地，由于雾化颗粒粒径分布的均匀程度与雾化孔的均匀程度密不可分，而震动片的表面粗糙度对雾化孔的均匀程度有重要影响，因此要保证雾化后雾化颗粒粒径的分布质量，需要将雾化片中金属振动片的表面粗糙度控制在一定范围内。本发明对微孔雾化片中震动片的表面粗糙度进行研究，通过降低震动片背水面的表面粗糙度，使得震动片表面更加平整，对震动片表面加工制作雾化孔时，雾化孔大小能分布得更加均匀，从而使雾化后液滴粒径的正态分布更窄，出雾更集中。
值得说明的是，发明人通过研究发现，震动片在加工雾化孔之前，并不区分浸水面和背水面，其两面的表面粗糙度一致。在震动片上加工出雾化孔后，震动片的表面粗糙度不会发生改变。在震动片上加工出雾化孔后，若改变背水面的表面粗糙度，雾化孔的分布均匀程度会发生变化，且雾化后液滴粒径的正态分布发生变化，若只改变浸水面的表面粗糙度，而背水面的表面粗糙度不变，雾化孔的分布均匀程度不会受到影响，雾化后液滴粒径的正态分布也不会受到影响。同时，发明人通过大量研究发现，当震动片的背水面的表面粗糙度大于150nm时，雾化颗粒粒径分布宽泛，虽然颗粒直径主要分布在1～10μm内，但是在25～350μm 范围内仍有一定程度的分布；而当震动片的背水面的表面粗糙度为150nm、100nm、50nm、10nm(误差不超过±20％时)，利用包含本发明所述微孔雾化片的雾化器进行雾化后的颗粒粒径分布呈正态分布，雾化颗粒均匀且高度集中，颗粒直径在1-10μm范围内的雾化颗粒所占比例高达96％以上，符合肺部给药的需求，从而可以极大地提高药物利用率，降低给药量。然而表面粗糙度越小，即震动片表面越光洁，其对加工设备及加工工艺条件要求更高，对应的成本也会更大，发明人认为，可根据自身需求，在雾化效果和材料成本之间平衡，选择具有合适表面粗糙度的微孔雾化片。在本发明的一些实施方式中，震动片浸水面的表面粗糙度与背水面的表面粗糙度相同。在另一些实施方式中，震动片浸水面的表面粗糙度与背水面的表面粗糙度不同。
优选的，所述震动片的材质为金属或高分子材料。
作为一种优选的技术方案，所述震动片的背水面表面粗糙度为10～120纳米。
作为一种优选的技术方案，所述震动片的背水面表面粗糙度为20～110纳米。
作为一种优选的技术方案，所述震动片的背水面表面粗糙度为50～100纳米。
作为一种优选的技术方案，所述雾化孔的形状为喇叭口状，所述雾化孔的两端分别为进水端和出水端，所述进水端的直径大于所述出水端的直径。
具体的，所述进水端位于所述浸水面一侧，所述出水端位于所述背水面一侧。利用具备所述喇叭口形状的微孔雾化片，有助于液体进入雾化孔完成雾化，并获得超微细雾化颗粒。
作为一种优选的技术方案，所述微孔区设有若干凸起，所述雾化孔位于凸起上。
具体的，所述微孔区设有凸起，可以有效增加雾化片与液体的接触面积，同时使经过雾化孔的颗粒往不同方向喷出，使雾化方向更发散，从而有效减少雾化颗粒之间的相互碰撞和溶合，导致颗粒增大增多。此外，采用这种结构还可以有效提高能量转换的效率，降低损耗功率和减小发热量。
作为一种优选的技术方案，所述震动片的浸水面和/或背水面设有防腐层。
具体的，通过在震动片的浸水面或背水面设置防腐层，或者震动片的浸水面和背水面均设置防腐层，可以使震动片与液体隔离，避免液体的腐蚀，使震动片得到保护，进而提高雾化片的耐腐蚀性，延长使用寿命。
作为一种优选的技术方案，所述防腐层为高分子釉。
具体的，高分子釉具有很好的耐酸碱性，防腐效果好。
本发明的有益效果为：提供一种微孔雾化片，通过优化震动片的表面粗糙度，使得震动片中的雾化孔分布更均匀，从而使雾化喷出的液滴粒径分布更窄更均一，实现量化定位给药的雾化效果。
附图说明
图1为本发明的结构示意图；
图2为本发明实施例一中微孔雾化片的剖视图；
图3为本发明实施例二中微孔雾化片的剖视图；
图4为图3中A处局部放大示意图；
图5为本发明实施例一中的微孔雾化片进行雾化后所得颗粒粒径分布图；
图6为本发明实施例三中的微孔雾化片进行雾化后所得颗粒粒径分布图；
图7为本发明实施例四中的微孔雾化片进行雾化后所得颗粒粒径分布图；
图8为本发明实施例五中的微孔雾化片进行雾化后所得颗粒粒径分布图。
其中，震动片1，空心环状压电陶瓷片2，微孔区3，雾化孔4，导线5，浸水面6，背水面7。
具体实施方式
为使对本发明的结构特征及所达成的功效有更进一步的了解和认识，用以较佳的实施例及附图配合详细的说明，说明如下：
实施例一
如图1和图2所示，一种微孔雾化片，包括震动片1和复合在震动片1振动中心的空心环状压电陶瓷片2，震动片1和空心环状压电陶瓷片2上分别引出一根导线5，用于传递电信号。对应空心环状压电陶瓷片2的中心圆孔位置的震动片1上设置有微孔区3，微孔区3内分布有多个雾化孔4。震动片1具有浸水面6和背水面7，雾化孔4形状呈喇叭口状，雾化孔4的两端分别为进水端和出水端，其中进水端的直径大于出水端的直径，进水端的直径为66微米，出水端直径为3微米，进水端与浸水面6连接，出水端与背水面7连接。雾化孔4的数量为3000个。震动片1的背水面7表面粗糙度为10纳米。
实施例二
如图3及图4所示，本实施例与实施例一的区别在于，微孔区3设有若干凸起，雾化孔4位于凸起上。
本实施例中其他结构与实施例一相同，在此不再赘述。
实施例三
本实施例与实施例一的区别在于，震动片1的背水面7表面粗糙度为50纳米。
本实施例中其他结构与实施例一相同，在此不再赘述。
实施例四
本实施例与实施例一的区别在于，震动片1的背水面7表面粗糙度为100纳米。
本实施例中其他结构与实施例一相同，在此不再赘述。
实施例五
本实施例与实施例一的区别在于，震动片1的背水面7表面粗糙度为150纳米。
本实施例中其他结构与实施例一相同，在此不再赘述。
实施例六
本实施例与实施例一的区别在于，震动片1的浸水面6和/或背水面7设有防腐层。防腐层为高分子釉。
本实施例中其他结构与实施例一相同，在此不再赘述。
粒径分布测试：
(1)测试方法：将上述各实施例的微孔雾化片分别装入雾化器中，对微孔雾化片提供一个超声频率，雾化片接受电信号后，空心环状压电陶瓷片2产生机械振动，空心环状压电陶瓷片2的机械振动带动震动片1产生振动，与震动片1接触的液体在振动过程中通过雾化孔4喷射出去，形成雾粒。使用上述雾化器对沙丁胺醇药液进行雾化，对雾化后所得的雾化颗粒粒径分布使用粒度分析仪进行测试。
(2)测试结果：图5示出了利用实施例一的微孔雾化片进行雾化后的颗粒粒径分布图；图6示出了利用实施例三的微孔雾化片进行雾化后的颗粒粒径分布图；图7示出了利用实施例四的微孔雾化片进行雾化后的颗粒粒径分布图；图8示出了利用实施例五的微孔雾化片进行雾化后的颗粒粒径分布图。由图5-8可以看出，当震动片1的背水面7的表面粗糙度小于150纳米时，即利用上述实施例的微孔雾化片进行雾化后的颗粒粒径分布集中，96％以上集中在1～10μm范围内。由此可知，利用本发明的微孔雾化片可以使雾化喷出的液滴颗粒粒径的正态分布更窄更均一，从而实现量化定位给药的雾化效果。
本发明未涉及的部分均与现有技术相同或可采用现有技术加以实现。
最后应说明的是：以上实施例仅用以说明本发明的技术方案，而非对其限制；尽管参照前述实施例对本发明进行了详细的说明，本领域的技术人员应当理解，其依然可以对前述实施例所记载的技术方案进行修改，或者对其中部分技术特征进行同等替换；而这些修改或者替换，并不使相应技术方案的本质脱离本发明各实施例技术方案的精神与范围。

Claims (8)

  1. 一种微孔雾化片，包括具有浸水面(6)和背水面(7)的震动片(1)，所述震动片(1)上设置有微孔区(3)，所述微孔区(3)内分布有多个雾化孔(4)，其特征在于，所述震动片(1)的背水面(7)表面粗糙度小于150纳米。
  2. 根据权利要求1所述的一种微孔雾化片，其特征在于，所述震动片(1)的背水面(7)表面粗糙度为10～120纳米。
  3. 根据权利要求1或2所述的一种微孔雾化片，其特征在于，所述震动片(1)的背水面(7)表面粗糙度为20～110纳米。
  4. 根据权利要求1或2或3所述的一种微孔雾化片，其特征在于，所述震动片(1)的背水面(7)表面粗糙度为50～100纳米。
  5. 根据权利要求1～4任意一项所述的一种微孔雾化片，其特征在于，所述雾化孔(4)的形状为喇叭口状，所述雾化孔(4)的两端分别为进水端和出水端，所述进水端的直径大于所述出水端的直径。
  6. 根据权利要求1～5任意一项所述的一种微孔雾化片，其特征在于，所述微孔区(3)设有若干凸起，所述雾化孔(4)位于凸起上。
  7. 根据权利要求1～6任意一项所述的一种微孔雾化片，其特征在于，所述震动片(1)的浸水面(6)和/或背水面(7)设有防腐层。
  8. 根据权利要求1～7任意一项所述的一种微孔雾化片，其特征在于，所述防腐层为高分子釉。
PCT/CN2019/080905 2018-04-03 2019-04-02 一种微孔雾化片 WO2019192441A1 (zh)

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CN111420188A (zh) * 2020-04-02 2020-07-17 重庆医科大学 一种高效振动雾化器
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