WO2019172740A1 - Formulation pour solidifier le sang d'origine animale - Google Patents

Formulation pour solidifier le sang d'origine animale Download PDF

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Publication number
WO2019172740A1
WO2019172740A1 PCT/MX2018/000035 MX2018000035W WO2019172740A1 WO 2019172740 A1 WO2019172740 A1 WO 2019172740A1 MX 2018000035 W MX2018000035 W MX 2018000035W WO 2019172740 A1 WO2019172740 A1 WO 2019172740A1
Authority
WO
WIPO (PCT)
Prior art keywords
blood
formulation
animal origin
further characterized
origin according
Prior art date
Application number
PCT/MX2018/000035
Other languages
English (en)
Spanish (es)
Inventor
Gerardo Alonso Torres Ávalos
Edith Ariadna LOZANO GONZÁLEZ
María Rebeca ENRÍQUEZ GUTIÉRREZ
Claudia Alejandra MACÍAS CHÁVEZ
Original Assignee
Instituto Tecnológico José Mario Molina Pasquel y Henriquez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instituto Tecnológico José Mario Molina Pasquel y Henriquez filed Critical Instituto Tecnológico José Mario Molina Pasquel y Henriquez
Publication of WO2019172740A1 publication Critical patent/WO2019172740A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/20—Animal feeding-stuffs from material of animal origin
    • A23K10/24—Animal feeding-stuffs from material of animal origin from blood

Definitions

  • the present invention is related to formulations for treating blood of animal origin, and more specifically is related to formulations for solidifying blood of animal origin.
  • animal blood can have various uses, such as protein source, to produce reagents for diagnosis and biotechnology or even to make cosmetics.
  • the main use of animal blood is as a source of protein.
  • Dried plasma can be given as feed to livestock animals or pets.
  • the procedures for treating animal blood are usually very complicated.
  • Products have also been developed to promote blood coagulation such as the prothrombin complex, fresh frozen plasma and precipitated cryo.
  • Another product that is commonly used is the recombinant human vile factor, which is used to treat major hemorrhages.
  • the tranexámlco and the aminocapróddo adduce inhibit fibrinólisls, and lead to a dlsminudón in the rate of bleeding.
  • Aprotinlna was also widely used in arugias to reduce bleeding bleeding and the need for blood products.
  • the present invention seeks to develop a liquid blood treatment method resulting from the processing of trace animals so that it can be used in the fed industry by applying similar ingredients to those used in the pharmaceutical industry.
  • the present invention solves all the problems and disadvantages identified in the background of the invention.
  • a first aspect of the present invention is a formulation for solidifying blood of animal origin comprising at least one gelling agent; a coagulation accelerating agent; and an edible vehicle.
  • a second aspect of the present invention is a method for obtaining a formulation for solidifying blood of animal origin comprising heating an edible vehicle; and add a gelling agent and a coagulation accelerator agent to the edible suspension medium until a homogeneous solder is obtained.
  • a third aspect of the present invention is a method for solidifying blood of animal origin that comprises maintaining a formulation to solidify blood of animal origin at a temperature between 50 and 70 ° C; add blood of animal origin in a liquid state to the formulation; shake the solderon until solid particles of blood are obtained; and separating said particles from the soludón.
  • a final aspect of the present invention is solid blood of animal origin, obtained by the method to solidify blood of animal origin of the present invention, with a density of between 1,080 and 1.12 g / mL, an average modulus of elasticity between 40 and 133 KPa, and a deviation from the mean square value (RMS) between 1.2 and 2.35 KPa.
  • RMS mean square value
  • a first aspect of the present invention is a formulation for solidifying blood of animal origin comprising at least one gelling agent; a coagulation accelerating agent; and an edible vehicle.
  • the gelling agent of the formulation is selected from among grenetina, guar gum and combinations thereof. Even more preferably, it is a combination of grenetina and guar gum.
  • the gelling agent of the formulation is in a concentration of between 1.5 and 14% by weight. Even more preferably in a concentration of 10% by weight.
  • the coagulation accelerating agent is broth chloride. In a preferred embodiment of the present invention, the coagulation accelerating agent is in a concentration of between 1 and 5% by weight. Even more preferably it is in a concentration of 1.4% by weight.
  • the edible carrier is selected from the groups of alcohols, diols, thiols, and combinations thereof.
  • it is selected from gllcerin, propylene glycol, ethanol, and combinations thereof.
  • the edible vehicle is in a concentration between 9.6 and 27% by weight. In an even more preferred embodiment it is in a concentration of 17% by weight.
  • the formulation additionally contains a preservative that does not intervene with the solidification reactions of the blood.
  • the preservative is selected from sodium benzoate and sodium propionate.
  • the preservative is in a concentration of between 0.05 and 0.1% by weight. Even more preferably, it is in a concentration of 0.1% by weight.
  • a second aspect of the present invention is a method of obtaining a formulation for solidifying blood of animal origin comprising heating an edible vehicle; and add a gelling agent and a coagulation accelerating agent to the edible suspension medium until a homogeneous solution is obtained.
  • the addition of the gelling agent and coagulation accelerating agent can be carried out simultaneously or by adding one after the other.
  • the edible vehicle is selected from the groups of alcohols, diols, thiols, and combinations thereof.
  • it is selected from glycerin, propylene glycol, ethanol, and combinations thereof.
  • the amount of edible vehicle that falls within the first stage of the method of the present invention is such that the final formulation contains a concentration of between 9.6 and 27% by weight of said edible vehicle.
  • the amount is such that the concentration is 10% by weight.
  • the edible vehicle is heated to a temperature between 50 and 70 ° C. Even more preferably it is at a temperature of 60 ° C.
  • the gelling agent is selected from grenetine, guar gum, and combinations thereof. Even more preferred is a combination of grenetina and guar gum.
  • the amount of gelling agent that is added to the edible carrier is such that the final formulation contains a concentration of gelling agent of between 1.5 and 20% by weight mL.
  • the amount is such that the concentration is 10% by weight.
  • the coaguladon accelerating agent is calcium chloride.
  • the amount of coagulation accelerating agent that is added to the edible vehicle is such that the final formulation contains a coagulation accelerating agent concentration of between 1 and 5% by weight.
  • the amount is such that the concentration is 1.4% by weight.
  • the gelling agent and the coagulation accelerating agent are added gradually with constant agitation.
  • the method opdonally comprises an additional step in which a preservative that does not intervene with the solidification reactions of the blood is added.
  • the preservative is selected from sodium benzoate and sodium propionate.
  • the preservative is added in an amount such that the concentration of said preservative in the final formulation is between 0.05 and 0.1% by weight.
  • it is added in an amount such that the concentration of said preservative in the final formulation is 0.1% by weight.
  • the strengthening of the mechanical properties of the solidified blood is achieved by the joint action of calcium chloride and the gelling agent (s).
  • the calcium ions present in the formulation promote blood coagulation while the gelling agent (s) dramatically decrease the mobility of semi-solid and particulate elements, such as cells and components derived from cells that constitute about 45% of the blood. Thanks to the synergistic acdon of these agents, it is possible to accelerate blood coagulation and thus obtain solid blood particles.
  • a third aspect of the present invention is a method for solidifying blood of animal origin comprising maintaining a formulation to solidify blood of animal origin at a temperature between 50 and 70 ° C; add blood of animal origin in liquid form to the formulation; stir the solution until solid particles of blood are obtained; and separating said particles from the solution.
  • the formulation for solidifying blood of animal origin is maintained at a temperature of 60 ° C.
  • the animal blood of the present invention can be directly extracted from the animal or it can come from some other procedure. However, it is necessary that said blood be in a liquid state.
  • Any known solid-liquid separation method can be used to separate the particles from the solution.
  • the method of solidification of the blood previously described achieves the strengthening of the mechanical properties of animal blood by forming a three-dimensional structure by acdon of the gelling agent and reinforcing said network by the formulation of the broth ions.
  • a final aspect of the present invention is solid blood of animal origin, obtained by the method to solidify blood of animal origin of the present invention, with a density of between 1,080 and 1.12 g / mL, an average modulus of elasticity between 40 and 133 KPa, and an average square value (RMS) between 1.2 and 2.35 KPa.
  • the density of the solid blood obtained is between 1,082 and 1,115 g / mL.
  • 1,111 g / mL Preferably, 1,111 g / mL.
  • the average elastic modulus of solid blood obtained is 56.6 KPa.
  • the mean quadratic value (RMS) of the solid blood obtained is 1.8 KPa.
  • formulation to solidify blood of animal origin has been devised to carry out solidification of blood of animal origin with efficiency, and it will be apparent to any person skilled in the art that the modalities of the formulation to solidify blood of animal origin as described above, they are only illustrative but not limiting of the present invention, since numerous changes of consideration in their details are possible without departing from the scope of the Invention.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne une formulation pour solidifier du sang d'origine animale au moyen d'un agent gélifiant, d'un agent accélérateur de la coagulation et d'un véhicule cosmestible ainsi que la méthode d'obtention d'une formulation pour solidifier du sang d'origine animale, une méthode pour solidifier du sang d'origine animale et du sang solide d'origine animale.
PCT/MX2018/000035 2018-03-09 2018-04-09 Formulation pour solidifier le sang d'origine animale WO2019172740A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MX2018002984A MX2018002984A (es) 2018-03-09 2018-03-09 Formulación para solidificar sangre de origen animal.
MXMX/A/2018/002984 2018-03-09

Publications (1)

Publication Number Publication Date
WO2019172740A1 true WO2019172740A1 (fr) 2019-09-12

Family

ID=67847415

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MX2018/000035 WO2019172740A1 (fr) 2018-03-09 2018-04-09 Formulation pour solidifier le sang d'origine animale

Country Status (2)

Country Link
MX (1) MX2018002984A (fr)
WO (1) WO2019172740A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4143168A (en) * 1975-12-08 1979-03-06 The Quaker Oats Company Shaped blood by-product and process
AU3892678A (en) * 1977-08-15 1980-02-21 Kliem Foods Pty. Ltd Production of food from blood
WO1991004672A1 (fr) * 1989-09-29 1991-04-18 Andrew Kalinowski Traitement du sang animal
CN1335100A (zh) * 2001-08-16 2002-02-13 徐大达 血干及其制法
CN102125165A (zh) * 2011-04-08 2011-07-20 汪前进 饲用血粉的生产方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4143168A (en) * 1975-12-08 1979-03-06 The Quaker Oats Company Shaped blood by-product and process
AU3892678A (en) * 1977-08-15 1980-02-21 Kliem Foods Pty. Ltd Production of food from blood
WO1991004672A1 (fr) * 1989-09-29 1991-04-18 Andrew Kalinowski Traitement du sang animal
CN1335100A (zh) * 2001-08-16 2002-02-13 徐大达 血干及其制法
CN102125165A (zh) * 2011-04-08 2011-07-20 汪前进 饲用血粉的生产方法

Also Published As

Publication number Publication date
MX2018002984A (es) 2019-09-10

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