WO2019153539A1 - 扩张参数确定方法、系统、计算机和存储介质 - Google Patents

扩张参数确定方法、系统、计算机和存储介质 Download PDF

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Publication number
WO2019153539A1
WO2019153539A1 PCT/CN2018/084995 CN2018084995W WO2019153539A1 WO 2019153539 A1 WO2019153539 A1 WO 2019153539A1 CN 2018084995 W CN2018084995 W CN 2018084995W WO 2019153539 A1 WO2019153539 A1 WO 2019153539A1
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Prior art keywords
blood vessel
balloon
expansion
normal blood
diameter
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PCT/CN2018/084995
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English (en)
French (fr)
Inventor
冯耿超
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深圳世格赛思医疗科技有限公司
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Priority to US16/969,348 priority Critical patent/US20210046293A1/en
Publication of WO2019153539A1 publication Critical patent/WO2019153539A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/1018—Balloon inflating or inflation-control devices
    • A61M25/10184—Means for controlling or monitoring inflation or deflation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/1018—Balloon inflating or inflation-control devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/104—Balloon catheters used for angioplasty
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M29/00—Dilators with or without means for introducing media, e.g. remedies
    • A61M29/02—Dilators made of swellable material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/504—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of blood vessels, e.g. by angiography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A61M2205/3334—Measuring or controlling the flow rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/12—Blood circulatory system

Definitions

  • the embodiments of the present application relate to the medical field, for example, to an expansion parameter determination method, system, computer, and storage medium.
  • Cardiovascular disease is a common disease that poses a serious threat to human health. Balloon expansion is commonly used clinically to treat cardiovascular disease.
  • a contrast agent or a physiological saline solution is injected into a balloon of a cardiovascular disease to change the pressure and shape of the balloon.
  • Digital Subtraction Angiography (DSA) equipment is used to clearly monitor the surgical procedure and determine the patient's affected area.
  • the balloon used for the dilatation stent in which the vascular affected area is expanded can be pressurized, so that the balloon is inflated to achieve the purpose of dilating the blood vessel.
  • the medical staff is required to use the DSA device to frequently check the balloon expansion to determine if the expansion is complete. Due to errors in human eye observation, there is a risk of rupture of blood vessels due to overexpansion.
  • Embodiments of the present application provide a method, system, computer, and storage medium for determining an expansion parameter to obtain accurate expansion parameters, and to reduce the number of times the balloon is expanded using a DSA device, and to avoid the risk of rupture of the blood vessel.
  • an embodiment of the present application provides a method for determining an expansion parameter, including:
  • a target expansion parameter of the blood vessel to be dilated is determined according to a diameter of the normal blood vessel and a preset expansion rule.
  • the embodiment of the present application further provides an expansion parameter determining system, including:
  • a liquid injection control module configured to control the balloon disposed in the normal blood vessel at a predetermined distance from the blood vessel to be expanded to continuously inject the liquid at a first rate
  • a first liquid pressure acquisition module configured to acquire a liquid pressure of the balloon
  • a normal blood vessel diameter determining module configured to determine a diameter of the normal blood vessel according to the first fluid pressure and a balloon parameter
  • the target expansion parameter determining module is configured to determine a target expansion parameter of the blood vessel to be expanded according to a diameter of the normal blood vessel and a preset expansion rule.
  • the embodiment of the present application further provides a computer, where the computer includes:
  • At least one processor At least one processor
  • a memory configured to store at least one program
  • the at least one program is executed by the at least one processor such that the at least one processor implements the expansion parameter determination method of any of the embodiments of the present application.
  • the embodiment of the present application further provides a computer readable storage medium, where a computer program is stored, and when the computer program is executed by the processor, the expansion parameter determining method according to any embodiment of the present application is implemented.
  • the target expansion parameter of the blood vessel to be expanded is determined according to the diameter of the normal blood vessel at a predetermined distance of the blood vessel to be expanded and the preset expansion rule, thereby obtaining a safe and accurate target expansion parameter, and achieving precise control of the balloon expansion. And reduce the number of times the balloon is dilated using the DSA, thereby reducing the radiation dose to the patient and the operator and avoiding the risk of rupture of the vessel during balloon dilation.
  • FIG. 1 is a flowchart of a method for determining an expansion parameter according to Embodiment 1.
  • Embodiment 2 is a flow chart of a method for determining an expansion parameter provided in Embodiment 2.
  • FIG. 3 is a schematic structural diagram of an expansion parameter determination system according to Embodiment 3.
  • FIG. 4 is a schematic structural view of a normal blood vessel diameter determining module.
  • FIG. 5 is a schematic structural diagram of a computer according to Embodiment 4.
  • FIG. 1 is a flowchart of a method for determining an expansion parameter according to Embodiment 1.
  • This embodiment can be applied to the determination of balloon expansion parameters, and can be applied to balloon dilatation surgery for treating cardiovascular diseases, and can also be used in other application scenarios where expansion parameters need to be determined.
  • the method can be performed by an expansion parameter determination system, which can be implemented by at least one of software and hardware, integrated into a computer. The method includes the following steps:
  • Step 110 Control the balloon disposed in the normal blood vessel at a predetermined distance from the blood vessel to be expanded to continuously inject the liquid at a first rate.
  • the blood vessel to be dilated may be, for example, a stenotic blood vessel at a lesion location.
  • the blood vessels to be dilated there is a clogging substance, so the blood cannot be circulated normally.
  • Normal blood vessels refer to blood vessels that allow blood to flow normally.
  • the normal blood vessel at the predetermined distance of the blood vessel to be expanded belongs to the same blood vessel as the blood vessel to be expanded.
  • the normal blood vessels selected at the periphery of the blood vessel to be dilated and belonging to the same blood vessel as the blood vessel to be dilated are optimal.
  • the predetermined distance may be determined according to the distance between the normal blood vessel belonging to the same blood vessel around the blood vessel to be dilated and the blood vessel to be dilated.
  • the normal blood vessel may be a blood vessel 5 cm away from the blood vessel of the lesion.
  • Step 120 Obtain a first fluid pressure of the balloon.
  • the first fluid pressure of the balloon provided in the normal blood vessel is obtained in real time.
  • the first liquid pressure can be monitored and acquired in real time by a pressure sensor.
  • Step 130 Determine a diameter of a normal blood vessel according to the first fluid pressure and the balloon parameter.
  • balloon parameters include, but are not limited to, balloon shape, balloon length, and balloon wall thickness.
  • shape of the balloon in this embodiment can be regarded as a regular cylinder.
  • step 130 includes:
  • Determining a pressure change rate of the balloon according to the change of the first liquid pressure determining a critical contact time of the balloon and the normal blood vessel according to the pressure change rate; acquiring a first liquid capacity of the balloon at the critical contact time, and according to the first liquid capacity and The balloon parameter determines the diameter of the normal blood vessel.
  • the pressure change rate of the balloon is determined according to the change of the first liquid pressure acquired in real time.
  • the value obtained by dividing the difference between the first liquid pressure at the current time and the first liquid pressure at the previous time by the time interval between the current time and the previous time is determined as the pressure change rate at the current time.
  • the pressure change rate of the balloon corresponding to each moment is sequentially determined.
  • the first liquid pressure change curve changes with time according to the first liquid pressure acquired in real time, and the slope of each point on the pressure change curve is the pressure change rate at the corresponding time.
  • the pressure change rate of the first fluid pressure of the balloon remains unchanged, both of which are liquid injection.
  • the first rate corresponds to the rate of change of pressure.
  • the critical contact timing of the balloon and the normal blood vessel can determine the critical contact timing of the balloon and the normal blood vessel according to the magnitude of the pressure change rate.
  • the critical contact moment may be the moment when the slope of the pressure change curve changes significantly.
  • the critical contact time of the balloon to the normal blood vessel is determined based on the rate of change of pressure, including:
  • the time corresponding to the difference is determined as the critical contact time of the balloon with the normal blood vessel.
  • the change amount of the pressure change rate at each moment is obtained, that is, the difference between the pressure change rate at each moment and the pressure change rate at the previous moment is obtained.
  • the difference between any two pressure change rates at this time is zero.
  • the pressure change rate of the balloon gradually decreases due to the obstruction of the balloon expansion by the normal blood vessel, so that the difference between the pressure change rate at the current time and the pressure change rate at the previous moment is Negative value.
  • the preset value can be set according to normal blood vessel parameters. When the absolute value of the difference is equal to or greater than the preset value, the injection of the liquid into the balloon is stopped, and the moment is determined as the critical contact timing of the balloon with the normal blood vessel.
  • the first liquid volume of the balloon at the critical contact time can be monitored and acquired in real time by the flow sensor.
  • the first liquid volume in this embodiment can be regarded as the volume of the balloon.
  • the diameter of the normal blood vessel can be determined based on the first fluid volume of the balloon and the balloon shape, balloon length, and balloon wall thickness in the balloon parameters.
  • the diameter of the balloon is first determined according to the first fluid volume of the balloon, the shape of the balloon, and the length of the balloon, and the diameter of the normal blood vessel is determined according to the diameter of the balloon and the thickness of the balloon wall.
  • the diameter of the normal blood vessel determined in accordance with the first fluid volume at the critical contact time in this embodiment is the maximum safe diameter of the balloon expansion in the vessel to be dilated.
  • the first liquid volume of the balloon is V 1
  • the shape of the balloon is a cylinder
  • the length of the balloon is m
  • the thickness of the balloon wall is h
  • the length m of the capsule can determine the diameter d of the balloon is
  • the diameter D of the normal blood vessel can be determined to be d + 2 h according to the diameter d of the balloon and the thickness h of the balloon wall.
  • Step 140 Determine a target expansion parameter of the blood vessel to be dilated according to a diameter of the normal blood vessel and a preset expansion rule.
  • the predetermined expansion rule may be an expandable coefficient of the blood vessel to be expanded determined according to the position of the blood vessel to be dilated, the cause of the patient, and the conventional treatment mode.
  • the expandable coefficient in this embodiment refers to the ratio of the expanded diameter of the blood vessel to be dilated to the diameter of the normal blood vessel. Due to the presence of a clogging substance in the blood vessel to be dilated, the expanded diameter of the blood vessel to be dilated is smaller than the diameter of the normal blood vessel to avoid rupture of the blood vessel to be dilated.
  • the target expansion parameters of the vessel to be dilated include, but are not limited to, the target expansion diameter of the vessel to be dilated.
  • the expandable coefficient of a blood vessel to be dilated of a patient is determined to be 70%, and the diameter of the normal blood vessel of the patient is 2 mm, and the target expansion diameter of the blood vessel to be dilated may be determined to be 1.4 mm.
  • a safe target expansion parameter can be determined based on the diameter of the normal blood vessel and the predetermined expansion rule.
  • the volume of fluid to be injected into the balloon in the vessel to be dilated can also be determined based on the target dilation diameter of the vessel to be dilated and the balloon parameters, thereby achieving precise control of balloon dilation.
  • the present embodiment can be applied to determine the target expansion parameters of the lesion blood vessel before expanding the lesion blood vessel, and expand the lesion blood vessel according to the target expansion parameter to improve the safety performance.
  • the target expansion parameter of the blood vessel to be expanded is determined according to the diameter of the normal blood vessel at a preset distance of the blood vessel to be expanded and the preset expansion rule, thereby obtaining a safe and accurate target expansion parameter, and achieving precise control of the balloon expansion. And reduce the number of times the balloon is dilated using the DSA, thereby reducing the radiation dose to the patient and the operator and avoiding the risk of rupture of the vessel during balloon dilation.
  • FIG. 2 is a flowchart of a method for determining an expansion parameter according to Embodiment 2.
  • the present embodiment is described on the basis of the above embodiment: determining a target expansion parameter of a blood vessel to be dilated according to a diameter of a normal blood vessel and a preset expansion rule. Thereafter, the method further includes: controlling injection of the liquid into the balloon to the second liquid volume, and acquiring a second liquid pressure corresponding to the second liquid volume; determining a blood vessel elasticity of the normal blood vessel according to the second liquid volume and the second fluid pressure, wherein The vascular elasticity of the normal blood vessel is used as the blood vessel elasticity of the blood vessel to be dilated; the target expansion parameter is adjusted according to the blood vessel elasticity of the blood vessel to be dilated.
  • Embodiment 2 provides an expansion parameter determination method including the following steps:
  • Step 210 Control the balloon disposed in the normal blood vessel at a predetermined distance from the blood vessel to be expanded to continuously inject the liquid at a first rate.
  • Step 220 Obtain a first fluid pressure of the balloon.
  • Step 230 determining the diameter of the normal blood vessel according to the first fluid pressure and the balloon parameter.
  • Step 240 Determine a target expansion parameter of the blood vessel to be dilated according to a diameter of the normal blood vessel and a preset expansion rule.
  • Step 250 controlling the injection of the liquid into the balloon to the second liquid volume, and acquiring the second liquid pressure corresponding to the second liquid capacity.
  • the liquid when the fluid is injected into the balloon in the normal blood vessel to the first liquid volume, that is, when the balloon is in critical contact with the normal blood vessel, the liquid can be continuously injected into the balloon to the second liquid volume, so that the balloon and the normal blood vessel Complete contact to detect the elasticity of the blood vessels.
  • the second liquid capacity is greater than the first liquid capacity.
  • the second fluid volume can be determined based on normal vascular parameters to ensure that normal blood vessels are not ruptured when injected into the second fluid volume.
  • the second liquid pressure corresponding to the second liquid capacity can be monitored and acquired by the pressure sensor.
  • Step 250 in this embodiment may be performed after step 240, or may be said to be performed before step 210.
  • Step 260 determining the blood vessel elasticity of the normal blood vessel according to the second liquid volume and the second fluid pressure, wherein the blood vessel elasticity of the normal blood vessel is used as the blood vessel elasticity of the blood vessel to be dilated.
  • the blood vessel elasticity of the normal blood vessel is the same as that of the blood vessel to be expanded, so that the blood vessel elasticity of the blood vessel to be dilated can be determined according to the blood vessel elasticity of the normal blood vessel.
  • step 260 includes:
  • the ratio of the second liquid volume to the second fluid pressure is determined as the expansion coefficient of the normal blood vessel; the blood vessel elasticity of the normal blood vessel is determined according to the expansion coefficient and the first predetermined elastic rule.
  • the first predetermined elastic rule includes a correspondence between a blood vessel elasticity and a expansion coefficient of a normal blood vessel.
  • the expansion coefficient k of the normal blood vessel is V/P
  • the unit of the expansion coefficient k is ML/cm water column.
  • the elasticity of the blood vessel in this embodiment can be divided into several grades, and the higher the grade, the better the elasticity of the blood vessel.
  • the elasticity of the blood vessel can be divided into a first elasticity, a second elasticity, and a third elasticity, and the degree of elasticity is sequentially lowered.
  • the first predetermined elastic rule may be a range of expansion coefficients corresponding to each blood vessel elasticity level. The level of blood vessel elasticity corresponding to the expansion coefficient of the normal blood vessel is determined by matching the expansion coefficient of the normal blood vessel with the first predetermined elastic rule.
  • Step 270 Adjust the target expansion parameter according to the blood vessel elasticity of the blood vessel to be dilated.
  • the target expansion parameter is adjusted according to the elasticity of the blood vessel, so that a better therapeutic effect can be obtained.
  • step 270 includes:
  • the amount of change in the expansion parameter of the blood vessel to be expanded is determined according to the blood vessel elasticity of the blood vessel to be expanded and the second predetermined elastic rule; the target expansion parameter is adjusted according to the amount of change in the expansion parameter.
  • the second predetermined elastic rule includes a correspondence between the elasticity of the blood vessel to be dilated and the amount of change in the expansion parameter of the blood vessel to be dilated.
  • the second preset elasticity rule may be an expansion parameter change amount corresponding to each elasticity level.
  • the amount of change in the expansion parameter in the present embodiment is relative to the diameter of the normal blood vessel, which includes the amount of increase in the expansion parameter and the amount of decrease in the expansion parameter.
  • the diameter of the normal blood vessel of the patient is 2 mm
  • the target dilation diameter of the blood vessel to be dilated is 1.4 mm. If the blood vessel elasticity of the blood vessel to be dilated is the first level, the first level corresponding to the second predetermined elastic rule is determined.
  • the increase in the expansion parameter can be 10%, and the increase in the expansion parameter is specifically 0.2 mm, so that the target expansion diameter of the blood vessel to be dilated increases from 1.4 mm to 1.6 mm. An increase in the target expansion diameter of the blood vessel to be dilated can achieve a better therapeutic effect without causing rupture of the blood vessel.
  • the reduction of the expansion parameter corresponding to the third level according to the second predetermined elastic rule may be 10%, and the reduction of the expansion parameter is specifically 0.2 mm, thereby achieving the target of the blood vessel to be dilated.
  • the expansion diameter was reduced from 1.4 mm to 1.2 mm.
  • the target expansion parameter of the blood vessel to be dilated is adjusted according to the elasticity of the blood vessel, thereby avoiding the rupture of the blood vessel. In case of better treatment results.
  • FIG. 3 is a schematic structural diagram of an expansion parameter determining system according to Embodiment 3.
  • the present embodiment is applicable to determining a balloon expansion parameter, and the system includes: a liquid injection control module 310, a first liquid pressure acquisition module 320, The normal vessel diameter determination module 330 and the target expansion parameter determination module 340.
  • the liquid injection control module 310 is configured to control the balloon disposed in the normal blood vessel at a predetermined distance from the blood vessel to be expanded to continuously inject the liquid at a first rate; the first liquid pressure acquiring module 320 is configured to acquire the balloon. a liquid pressure; a normal blood vessel diameter determining module 330 configured to determine a diameter of the normal blood vessel according to the first fluid pressure and a balloon parameter; a target expansion parameter determining module 340 configured to be based on a diameter and a pre-measurement of the normal blood vessel An expansion rule is set to determine a target expansion parameter of the blood vessel to be dilated.
  • the normal blood vessel diameter determining module 330 includes:
  • the pressure change rate determining unit 331 is configured to determine a pressure change rate of the balloon according to the change of the first liquid pressure; the critical contact time determining unit 332 is configured to determine the balloon and the seat according to the pressure change rate a critical contact time of the normal blood vessel; a first liquid volume acquisition unit 333 configured to acquire a first liquid capacity of the balloon at the critical contact time; a normal blood vessel diameter determining unit 334 configured to be according to the first liquid The volume and the balloon parameters determine the diameter of the normal blood vessel.
  • the critical contact timing determining unit 332 includes:
  • a difference obtaining subunit configured to obtain a difference between a pressure change rate of the balloon at each moment of the first liquid pressure change and a pressure change rate of a previous moment
  • a critical contact time determination subunit configured to determine, when the difference is less than zero, and an absolute value of the difference is equal to or greater than a preset value, determining a time corresponding to the difference as the balloon and the The critical contact moment of normal blood vessels.
  • system further comprises:
  • a second liquid volume control module configured to control injecting a liquid into the balloon to a second liquid volume after determining a target expansion parameter of the blood vessel to be dilated according to a diameter of the normal blood vessel and a predetermined expansion rule;
  • a blood vessel elasticity determining module configured to determine a blood vessel elasticity of the normal blood vessel according to the second liquid volume and the second fluid pressure, wherein a blood vessel elasticity of the normal blood vessel is used as a blood vessel elasticity of the blood vessel to be dilated;
  • the target expansion parameter adjustment module is configured to adjust the target expansion parameter according to a blood vessel elasticity of the blood vessel to be dilated.
  • the blood vessel elasticity determining module comprises:
  • An expansion coefficient determining unit configured to determine a ratio of the second liquid capacity and the second liquid pressure as an expansion coefficient of the normal blood vessel
  • the blood vessel elasticity determining unit is configured to determine the blood vessel elasticity of the normal blood vessel according to the expansion coefficient and the first predetermined elastic rule.
  • the target expansion parameter adjustment module comprises:
  • the expansion parameter change amount determining unit is configured to determine an expansion parameter change amount of the blood vessel to be expanded according to a blood vessel elasticity of the blood vessel to be expanded and a second predetermined elastic rule;
  • the target expansion parameter adjustment unit is configured to adjust the target expansion parameter according to the expansion parameter change amount.
  • the expansion parameter determination system provided by the embodiment of the present application may perform the expansion parameter determination method provided by any embodiment of the present application, and has the functions and beneficial effects corresponding to the expansion parameter determination method.
  • FIG. 5 is a schematic structural diagram of a computer according to Embodiment 4. Referring to Figure 5, the computer includes:
  • At least one processor 410 At least one processor 410;
  • the memory 420 is configured to store at least one program
  • the at least one processor 410 When the at least one program is executed by the at least one processor 410, the at least one processor 410 implements the expansion parameter determination method proposed by any of the above embodiments.
  • a processor 410 is taken as an example; the processor 410 and the memory 420 in the computer may be connected by a bus or other means, and the bus connection is taken as an example in FIG.
  • the memory 420 is used as a computer readable storage medium, and can be used to store a software program, a computer executable program, and a module, such as a program instruction/module corresponding to the expansion parameter determination method in the embodiment of the present application (for example, in an expansion parameter determination system)
  • the processor 410 executes various functional applications of the computer and data processing by executing software programs, instructions, and modules stored in the memory 420, that is, implementing the above-described expanded parameter determining method.
  • the memory 420 includes a storage program area and a storage data area, wherein the storage program area can store an operating system, an application required for at least one function; the storage data area can store data created according to usage of the computer, and the like.
  • memory 420 can include high speed random access memory, and can also include non-volatile memory, such as at least one magnetic disk storage device, flash memory device, or other non-volatile solid state storage device.
  • memory 420 can include memory remotely located relative to processor 410, which can be connected to a computer over a network. Examples of such networks include, but are not limited to, the Internet, intranets, local area networks, mobile communication networks, and combinations thereof.
  • the computer proposed by the embodiment is the same as the method for determining the expansion parameter proposed in the foregoing embodiment.
  • the computer of the embodiment has the same method as the determination method of the expansion parameter. The benefits.
  • the embodiment provides a computer readable storage medium.
  • the computer readable storage medium stores a computer program.
  • the computer program is executed by the processor, the method for determining an expansion parameter according to any embodiment of the present application is implemented.
  • the present application can be implemented by software and necessary general hardware, or can be implemented by hardware.
  • the technical solution of the present application may be embodied in the form of a software product, which may be stored in a computer readable storage medium, such as a computer floppy disk, a read-only memory (ROM), a random access memory ( Random Access Memory (RAM), flash memory (FLASH), hard disk or optical disk, etc., including instructions for causing a computer device (which may be a personal computer, a server, or a network device, etc.) to perform the operations described in each embodiment of the present application. method.
  • a computer device which may be a personal computer, a server, or a network device, etc.
  • the method, system, computer and storage medium for determining the expansion parameters provided by the embodiments of the present application can achieve precise control of balloon expansion and avoid the risk of blood vessel rupture during balloon expansion.

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Abstract

一种扩张参数确定方法，包括：控制相对待扩张血管预设距离处的正常血管中设置的球囊以第一速率持续注入液体(110)；获取该球囊的第一液体压力(120)；根据该第一液体压力与球囊参数确定正常血管的直径(130)；根据正常血管的直径和预设扩张规则确定待扩张血管的目标扩张参数(140)。还公开了利用该方法的系统、计算机和存储介质。

Description

扩张参数确定方法、系统、计算机和存储介质 技术领域
本申请实施例涉及医疗领域，例如涉及一种扩张参数确定方法、系统、计算机和存储介质。
背景技术
心血管疾病是一种严重威胁人类健康的常见病。临床上通常采用球囊扩张法来治疗心血管疾病。在心血管狭窄及堵塞手术中，将造影剂或生理盐水溶液等，加压注入心血管病患处的球囊中，从而改变球囊压力与外形。并利用数字减影心血管造影术(Digital Subtraction Angiography，DSA)设备对手术治疗过程及确定患者的患处进行明确的监视。同时还可以通过对血管患处扩张的扩张支架所用球囊进行加压，使得球囊膨胀从而达到扩张血管的目的。
然而，在对病患处的球囊进行加压时，需要医护人员利用DSA设备频繁查看球囊扩张情况，以确定是否完成扩张。由于人眼观察存在误差，所以可能会存在因扩张过度而导致血管破裂的风险。
发明内容
本申请实施例提供一种扩张参数确定方法、系统、计算机和存储介质，以获取精确的扩张参数，以及减少使用DSA设备查看球囊扩张情况的次数，并避免血管破裂的风险。
第一方面，本申请实施例提供了一种扩张参数确定方法，包括：
控制相对待扩张血管预设距离处的正常血管中设置的球囊以第一速率持续注入液体；
获取所述球囊的第一液体压力；
根据所述第一液体压力与球囊参数确定所述正常血管的直径；
根据所述正常血管的直径和预设扩张规则确定所述待扩张血管的目标扩张参数。
第二方面，本申请实施例还提供了一种扩张参数确定系统，包括：
液体注入控制模块，设置为控制相对待扩张血管预设距离处的正常血管中设置的球囊以第一速率持续注入液体；
第一液体压力获取模块，设置为获取所述球囊的液体压力；
正常血管直径确定模块，设置为根据所述第一液体压力与球囊参数确定所述正常血管的直径；
目标扩张参数确定模块，设置为根据所述正常血管的直径和预设扩张规则确定所述待扩张血管的目标扩张参数。
第三方面，本申请实施例还提供了一种计算机，所述计算机包括：
至少一个处理器；
存储器，设置为存储至少一个程序；
当所述至少一个程序被所述至少一个处理器执行，使得所述至少一个处理器实现本申请任意实施例所述的扩张参数确定方法。
第四方面，本申请实施例还提供了一种计算机可读存储介质，存储有计算机程序，所述计算机程序被处理器执行时实现如本申请任意实施例所述的扩张参数确定方法。
本申请实施例通过根据待扩张血管预设距离处的正常血管的直径和预设扩张规则确定待扩张血管的目标扩张参数，从而获取安全精确的目标扩张参数，实现对球囊扩张的精确控制，以及减少使用DSA查看球囊扩张情况的次数，进而减少对患者和操作者的辐射剂量，并避免了球囊扩张过程中血管破裂的风险。
附图说明
图1是实施例一提供的一种扩张参数确定方法的流程图。
图2是实施例二提供的一种扩张参数确定方法的流程图。
图3是实施例三提供的一种扩张参数确定系统的结构示意图。
图4是正常血管直径确定模块的结构示意图。
图5是实施例四提供的一种计算机的结构示意图。
具体实施方式
下面结合附图和实施例对本申请作进一步的说明。可以理解的是，此处所描述的实施例仅仅用于解释本申请，而非对本申请的限定。为了便于描述，附图中仅示出了与本申请相关的部分而非全部结构。
实施例一
图1为实施例一提供的一种扩张参数确定方法的流程图。本实施例可适用于确定球囊扩张参数的情况，可应用于治疗心血管疾病的球囊扩张手术中，也可以用于其他需要确定扩张参数的应用场景中。该方法可以由扩张参数确定系统来执行，该系统可以由软件和硬件中的至少一种方式来实现，集成于计算机中。该方法包括以下步骤：
步骤110、控制相对待扩张血管预设距离处的正常血管中设置的球囊以第一速率持续注入液体。
其中，待扩张血管例如可以是病灶位置处的狭窄血管。待扩张血管中因存在堵塞物质，所以无法使血液正常流通。正常血管指的是可以使血液正常流通的血管。本实施例中在待扩张血管预设距离处的正常血管与待扩张血管属于同一根血管。在一实施例中，在待扩张血管周围处选取的，并与待扩张血管属于同一根血管的正常血管最佳。预设距离可以根据待扩张血管周围处属于同一血管的正常血管与待扩张血管之间的距离确定，示例性的，正常血管可以是距离病灶血管5厘米处的血管。当球囊放置于正常血管中后，控制液体以第一速率持续注入球囊中，从而对球囊进行加压，使得球囊扩张。通过控制液体的注入速率保持不变，从而保证在球囊扩张初始阶段，球囊中的液体压力以相同的压力变化率持续增加。其中，球囊可以是通过穿刺的方式进入正常血管。
步骤120、获取球囊的第一液体压力。
其中，在液体注入球囊过程中，实时获取正常血管中设置的球囊的第一液体压力。本实施例可以通过压力传感器来实时监测和获取第一液体压力。
步骤130、根据第一液体压力与球囊参数确定正常血管的直径。
其中，球囊参数包括但不限于球囊形状、球囊长度和球囊壁厚度。本实施例中的球囊形状可视为规则圆柱体。
在一实施例中，步骤130包括：
根据第一液体压力的变化确定球囊的压力变化率；根据压力变化率确定球囊与正常血管的临界接触时刻；获取球囊在临界接触时刻的第一液体容量，并根据第一液体容量和球囊参数确定正常血管的直径。
其中，根据实时获取的第一液体压力的变化确定球囊的压力变化率。示例 性的，将当前时刻的第一液体压力与前一时刻的第一液体压力的差值，除以当前时刻与前一时刻的时间间隔得到的值确定为当前时刻的压力变化率。根据相同的确定方法，依次确定每一时刻对应的球囊的压力变化率。在一实施例中，根据实时获取的第一液体压力生成随时间变化的第一液体压力变化曲线，该压力变化曲线上每个点的斜率为对应时刻的压力变化率。在球囊扩张过程中，于球囊与正常血管接触之前，由于向球囊中注入液体的速率保持不变，所以球囊的第一液体压力的压力变化率也保持不变，均为液体注入的第一速率对应的压力变化率。在球囊与正常血管接触时，由于正常血管可以对球囊扩张产生阻碍作用力，该阻碍作用力与第一液体压力的方向相反，所以此时球囊中的第一液体压力会减小，从而导致对应的压力变化率也减小。因此本实施例可以根据压力变化率的大小来确定球囊与正常血管的临界接触时刻。示例性的，临界接触时刻可以是压力变化曲线中斜率存在明显变化的时刻。
在一实施例中，根据压力变化率确定球囊与正常血管的临界接触时刻，包括：
获取所述球囊在所述第一液体压力变化过程中每一时刻的压力变化率与前一时刻的压力变化率的差值；当差值小于零，且差值的绝对值等于或大于预设值时，将差值对应的时刻确定为球囊与正常血管的临界接触时刻。
其中，在确定每一时刻的压力变化率后，获取每一时刻压力变化率的改变量，即获取每一时刻的压力变化率与前一时刻的压力变化率的差值。在球囊与正常血管接触之前，由于每一时刻的压力变化率保持不变，所以此时任意两个压力变化率的差值均是零。在球囊与正常血管接触时，由于正常血管对球囊扩张的阻碍作用使得球囊的压力变化率逐渐减小，从而导致当前时刻的压力变化率与前一时刻的压力变化率的差值为负值。预设值可以根据正常血管参数进行设置。当差值的绝对值等于或大于预设值时，停止向球囊中注入液体，并将该时刻确定为球囊与正常血管的临界接触时刻。
在一实施例中，球囊在临界接触时刻的第一液体容量可以通过流量传感器实时监测和获取。本实施例中的第一液体容量可视为球囊的体积。在一实施例中，根据球囊的第一液体容量和球囊参数中的球囊形状、球囊长度和球囊壁厚 度可以确定正常血管的直径。先根据球囊的第一液体容量、球囊形状和球囊长度确定球囊的直径，再根据球囊的直径和球囊壁厚度确定正常血管的直径。本实施例中根据临界接触时刻的第一液体容量确定的正常血管的直径为待扩张血管中球囊扩张的最大安全直径。
示例性的，若球囊的第一液体容量为V 1，球囊的形状为圆柱体，球囊长度为m，球囊壁厚度为h，则根据球囊的第一液体容量V 1和球囊长度m可以确定球囊的直径d为
Figure PCTCN2018084995-appb-000001
根据球囊的直径d和球囊壁厚度h可以确定正常血管的直径D为d+2h。
步骤140、根据正常血管的直径和预设扩张规则确定待扩张血管的目标扩张参数。
其中，预设扩张规则可以是根据待扩张血管的位置、患者病因以及常规治疗方式确定的待扩张血管的可扩张系数。本实施例中的可扩张系数指的是待扩张血管的扩张直径与正常血管直径的比值。因待扩张血管中堵塞物质的存在，待扩张血管的扩张直径小于正常血管的直径，以避免待扩张血管的破裂。待扩张血管的目标扩张参数包括但不限于待扩张血管的目标扩张直径。示例性的，根据预设扩张规则确定某一患者的待扩张血管的可扩张系数为70％，该患者的正常血管的直径为2毫米，则可以确定待扩张血管的目标扩张直径为1.4毫米。根据正常血管的直径和预设扩张规则可以确定安全的目标扩张参数。将安全的目标扩张参数自动应用于待扩张血管中的球囊扩张，从而减少利用DSA设备查看球囊扩张情况的次数，进而减少对患者和操作者的辐射剂量，并且避免了因人眼观察导致的球囊扩张的不准确性，以及因加压过度出现的血管破裂或者因扩张程度不够出现的治疗效果不佳的情况。在一实施例中，根据待扩张血管的目标扩张直径以及球囊参数也可以确定对待扩张血管中的球囊需注入的液体容量，从而实现对球囊扩张的精确控制。
其中，本实施例可以应用在对病灶血管进行扩张之前，确定对病灶血管的目标扩张参数，并依据目标扩张参数对病灶血管进行扩张操作，提高安全性能。
本申请实施例通过根据待扩张血管预设距离处的正常血管的直径和预设扩张规则确定待扩张血管的目标扩张参数，从而获取安全精确的目标扩张参数， 实现对球囊扩张的精确控制，以及减少使用DSA查看球囊扩张情况的次数，进而减少对患者和操作者的辐射剂量，并避免了球囊扩张过程中血管破裂的风险。
实施例二
图2为实施例二提供的一种扩张参数确定方法的流程图，本实施例在上述实施例的基础上进行描述：在根据正常血管的直径和预设扩张规则确定待扩张血管的目标扩张参数之后，还包括：控制向球囊注入液体至第二液体容量，并获取第二液体容量对应的第二液体压力；根据第二液体容量与第二液体压力确定正常血管的血管弹性，其中，将正常血管的血管弹性作为待扩张血管的血管弹性；根据待扩张血管的血管弹性调节目标扩张参数。
实施例二提供一种扩张参数确定方法包括以下步骤：
步骤210、控制相对待扩张血管预设距离处的正常血管中设置的球囊以第一速率持续注入液体。
步骤220、获取球囊的第一液体压力。
步骤230、根据第一液体压力与球囊参数确定正常血管的直径。
步骤240、根据正常血管的直径和预设扩张规则确定待扩张血管的目标扩张参数。
步骤250、控制向球囊注入液体至第二液体容量，并获取第二液体容量对应的第二液体压力。
其中，在向正常血管中的球囊注入液体至第一液体容量时，即球囊与正常血管临界接触时，可继续向该球囊中注入液体至第二液体容量，使球囊与正常血管完全接触，以检测血管的弹性情况。其中，第二液体容量大于第一液体容量。第二液体容量可以根据正常血管参数来确定，以保证注入至第二液体容量时不会使正常血管破裂。本实施例可以通过压力传感器来监测和获取第二液体容量对应的第二液体压力。
本实施例中步骤250可以是在步骤240之后执行，也可以说在步骤210之前执行。
步骤260、根据第二液体容量与第二液体压力确定正常血管的血管弹性，其中，将正常血管的血管弹性作为待扩张血管的血管弹性。
本实施例中由于正常血管和待扩张血管属于同一根血管，所以正常血管的血管弹性与待扩张血管的血管弹性相同，从而可以根据正常血管的血管弹性确定待扩张血管的血管弹性。
在一实施例中，步骤260包括：
将第二液体容量和第二液体压力的比值确定为正常血管的膨胀系数；根据膨胀系数与第一预设弹性规则确定正常血管的血管弹性。其中第一预设弹性规则包括正常血管的血管弹性与膨胀系数的对应关系。
示例性的，若第二液体容量为V 2，第二液体压力为F，则正常血管的膨胀系数k为V/P，膨胀系数k的单位为毫升/厘米水柱。本实施例中的血管弹性可以分为若干个等级，等级越高表示血管弹性越好。例如，血管弹性可以分为第一弹性、第二弹性和第三弹性，弹性程度依次降低。第一预设弹性规则可以是每个血管弹性等级对应的膨胀系数范围。通过将正常血管的膨胀系数与第一预设弹性规则相匹配，从而确定正常血管的膨胀系数对应的血管弹性的等级。
步骤270、根据待扩张血管的血管弹性调节目标扩张参数。
其中，在待扩张血管不破裂的情况下，待扩张血管的目标扩张直径越大，则血液流通越顺畅，治疗效果越好。因此根据血管弹性情况来调节目标扩张参数，从而可以获取更好的治疗效果。
在一实施例中，步骤270包括：
根据待扩张血管的血管弹性和第二预设弹性规则确定待扩张血管的扩张参数改变量；根据扩张参数改变量调节目标扩张参数。其中第二预设弹性规则包括待扩张血管的血管弹性与待扩张血管的扩张参数改变量的对应关系。
其中，第二预设弹性规则可以是每个弹性等级对应的扩张参数改变量。本实施例中的扩张参数改变量是相对于正常血管的直径而言，其包括扩张参数增加量和扩张参数减少量。
示例性的，患者的正常血管的直径为2毫米，待扩张血管的目标扩张直径为1.4毫米，若待扩张血管的血管弹性为第一等级，根据第二预设弹性规则确定第一等级对应的扩张参数增加量可以为10％，则扩张参数增加量具体为0.2毫米，从而待扩张血管的目标扩张直径从1.4毫米增加到1.6毫米。在不会导致 血管破裂的情况下，待扩张血管的目标扩张直径的增加可以获取更好的治疗效果。若待扩张血管的血管弹性为第三等级，根据第二预设弹性规则确定第三等级对应的扩张参数减少量可以为10％，则扩张参数减少量具体为0.2毫米，从而待扩张血管的目标扩张直径从1.4毫米减少到1.2毫米。当血管弹性程度差时，需要减少待扩张血管的目标扩张直径，从而避免球囊扩张时导致血管破裂的风险。
本申请实施例通过根据待扩张血管预设距离处的正常血管的直径和预设扩张规则确定待扩张血管的目标扩张参数之后，根据血管弹性调节待扩张血管的目标扩张参数，从而在避免血管破裂的情况下，获取更好的治疗效果。
实施例三
图3为实施例三提供的一种扩张参数确定系统的结构示意图，本实施例可适用于确定球囊扩张参数的情况，该系统包括：液体注入控制模块310、第一液体压力获取模块320、正常血管直径确定模块330和目标扩张参数确定模块340。
其中，液体注入控制模块310，设置为控制相对待扩张血管预设距离处的正常血管中设置的球囊以第一速率持续注入液体；第一液体压力获取模块320，设置为获取所述球囊的液体压力；正常血管直径确定模块330，设置为根据所述第一液体压力与球囊参数确定所述正常血管的直径；目标扩张参数确定模块340，设置为根据所述正常血管的直径和预设扩张规则确定所述待扩张血管的目标扩张参数。
在一实施例中，参考图4，正常血管直径确定模块330包括：
压力变化率确定单元331，设置为根据所述第一液体压力的变化确定所述球囊的压力变化率；临界接触时刻确定单元332，设置为根据所述压力变化率确定所述球囊与所述正常血管的临界接触时刻；第一液体容量获取单元333，设置为获取所述球囊在所述临界接触时刻的第一液体容量；正常血管直径确定单元334，设置为根据所述第一液体容量和所述球囊参数确定所述正常血管的直径。
在一实施例中，临界接触时刻确定单元332包括：
差值获取子单元，设置为获取所述球囊在所述第一液体压力变化过程中每一时刻的压力变化率与前一时刻的压力变化率的差值；
临界接触时刻确定子单元，设置为当所述差值小于零，且所述差值的绝对值等于或大于预设值时，将所述差值对应的时刻确定为所述球囊与所述正常血管的临界接触时刻。
在一实施例中，该系统还包括：
第二液体容量控制模块，设置为在根据所述正常血管的直径和预设扩张规则确定所述待扩张血管的目标扩张参数之后，控制向所述球囊注入液体至第二液体容量；
第二液体压力获取模块，设置为获取所述第二液体容量对应的第二液体压力；
血管弹性确定模块，设置为根据所述第二液体容量与所述第二液体压力确定所述正常血管的血管弹性，其中，将所述正常血管的血管弹性作为所述待扩张血管的血管弹性；
目标扩张参数调节模块，设置为根据所述待扩张血管的血管弹性调节所述目标扩张参数。
在一实施例中，血管弹性确定模块包括：
膨胀系数确定单元，设置为将所述第二液体容量和所述第二液体压力的比值确定为所述正常血管的膨胀系数；
血管弹性确定单元，设置为根据所述膨胀系数与第一预设弹性规则确定所述正常血管的血管弹性。
在一实施例中，目标扩张参数调节模块包括：
扩张参数改变量确定单元，设置为根据所述待扩张血管的血管弹性和第二预设弹性规则确定所述待扩张血管的扩张参数改变量；
目标扩张参数调节单元，设置为根据所述扩张参数改变量调节所述目标扩张参数。
本申请实施例提供的扩张参数确定系统可执行本申请任意实施例所提供的扩张参数确定方法，具备与扩张参数确定方法相应的功能和有益效果。
实施例四
图5是实施例四提供的一种计算机的结构示意图。参见图5，该计算机包括：
至少一个处理器410；
存储器420，设置为存储至少一个程序；
当上述至少一个程序被上述至少一个处理器410执行，使得上述至少一个处理器410实现上述任意实施例提出的扩张参数确定方法。
图5中以一个处理器410为例；计算机中的处理器410和存储器420可以通过总线或其他方式连接，图5中以通过总线连接为例。
存储器420作为一种计算机可读存储介质，可用于存储软件程序、计算机可执行程序以及模块，如本申请实施例中的扩张参数确定方法对应的程序指令/模块(例如，扩张参数确定系统中的液体注入控制模块310、第一液体压力获取模块320、正常血管直径确定模块330和目标扩张参数确定模块340)。处理器410通过运行存储在存储器420中的软件程序、指令以及模块，从而执行计算机的多种功能应用以及数据处理，即实现上述扩张参数确定方法。
存储器420包括存储程序区和存储数据区，其中，存储程序区可存储操作系统、至少一个功能所需的应用程序；存储数据区可存储根据计算机的使用所创建的数据等。此外，存储器420可以包括高速随机存取存储器，还可以包括非易失性存储器，例如至少一个磁盘存储器件、闪存器件、或其他非易失性固态存储器件。在一些实例中，存储器420可包括相对于处理器410远程设置的存储器，这些远程存储器可以通过网络连接至计算机。上述网络的实例包括但不限于互联网、企业内部网、局域网、移动通信网及其组合。
本实施例提出的计算机与上述实施例提出的扩张参数确定方法属于同一构思，未在本实施例中详尽描述的技术细节可参见上述实施例，并且本实施例的计算机具备与扩张参数确定方法相同的有益效果。
实施例五
本实施例提供一种计算机可读存储介质，计算机可读存储介质中存储有计算机程序，上述计算机程序被处理器执行时实现如本申请任意一实施例所述的扩张参数确定方法。
通过以上关于实施方式的描述，所属领域的技术人员可以清楚地了解到，本申请可借助软件及必需的通用硬件来实现，也可以通过硬件实现。本申请的 技术方案可以以软件产品的形式体现出来，该计算机软件产品可以存储在计算机可读存储介质中，如计算机的软盘、只读存储器(Read-Only Memory，ROM)、随机存取存储器(Random Access Memory，RAM)、闪存(FLASH)、硬盘或光盘等，包括若干指令用以使得一台计算机设备(可以是个人计算机，服务器，或者网络设备等)执行本申请每个实施例所述的方法。
工业实用性
本申请实施例提供的扩张参数确定方法、系统、计算机和存储介质，可以实现对球囊扩张的精确控制，避免了球囊扩张过程中血管破裂的风险。

Claims (12)

  1. 一种扩张参数确定方法，包括：
    控制相对待扩张血管预设距离处的正常血管中设置的球囊以第一速率持续注入液体；
    获取所述球囊的第一液体压力；
    根据所述第一液体压力与球囊参数确定所述正常血管的直径；
    根据所述正常血管的直径和预设扩张规则确定所述待扩张血管的目标扩张参数。
  2. 根据权利要求1所述方法，其中，根据所述第一液体压力与球囊参数确定所述正常血管的直径，包括：
    根据所述第一液体压力的变化确定所述球囊的压力变化率；
    根据所述压力变化率确定所述球囊与所述正常血管的临界接触时刻；
    获取所述球囊在所述临界接触时刻的第一液体容量，并根据所述第一液体容量和所述球囊参数确定所述正常血管的直径。
  3. 根据权利要求2所述方法，其中，根据所述压力变化率确定所述球囊与所述正常血管的临界接触时刻，包括：
    获取所述球囊在所述第一液体压力变化过程中每一时刻的压力变化率与前一时刻的压力变化率的差值；
    当所述差值小于零，且所述差值的绝对值等于或大于预设值时，将所述差值对应的时刻确定为所述球囊与所述正常血管的临界接触时刻。
  4. 根据权利要求1所述方法，其中，在根据所述正常血管的直径和预设扩张规则确定所述待扩张血管的目标扩张参数之后，还包括：
    控制向所述球囊注入液体至第二液体容量，并获取所述第二液体容量对应的第二液体压力；
    根据所述第二液体容量与所述第二液体压力确定所述正常血管的血管弹性，其中，将所述正常血管的血管弹性作为所述待扩张血管的血管弹性；
    根据所述待扩张血管的血管弹性调节所述目标扩张参数。
  5. 根据权利要求4所述的方法，其中，根据所述第二液体容量与所述第二液体压力确定所述正常血管的血管弹性，包括：
    将所述第二液体容量和所述第二液体压力的比值确定为所述正常血管的膨胀系数；
    根据所述膨胀系数与第一预设弹性规则确定所述正常血管的血管弹性，其 中所述第一预设弹性规则包括所述正常血管的血管弹性与所述膨胀系数的对应关系。
  6. 根据权利要求4所述的方法，其中，根据所述待扩张血管的血管弹性调节所述目标扩张参数，包括：
    根据所述待扩张血管的血管弹性和第二预设弹性规则确定所述待扩张血管的扩张参数改变量，其中所述第二预设弹性规则包括所述待扩张血管的血管弹性与所述待扩张血管的扩张参数改变量的对应关系；
    根据所述扩张参数改变量调节所述目标扩张参数。
  7. 根据权利要求1-6中任一项所述的方法，其中，所述预设扩张规则包括所述待扩张血管的可扩张系数，所述待扩张血管的可扩张系数为所述待扩张血管的扩张直径与所述正常血管直径的比值。
  8. 一种扩张参数确定系统，包括：
    液体注入控制模块，设置为控制相对待扩张血管预设距离处的正常血管中设置的球囊以第一速率持续注入液体；
    第一液体压力获取模块，设置为获取所述球囊的液体压力；
    正常血管直径确定模块，设置为根据所述第一液体压力与球囊参数确定所述正常血管的直径；
    目标扩张参数确定模块，设置为根据所述正常血管的直径和预设扩张规则确定所述待扩张血管的目标扩张参数。
  9. 根据权利要求8所述的系统，其中，所述正常血管直径确定模块，包括：
    压力变化率确定单元，设置为根据所述第一液体压力的变化确定所述球囊的压力变化率；
    临界接触时刻确定单元，设置为根据所述压力变化率确定所述球囊与所述正常血管的临界接触时刻；
    第一液体容量获取单元，设置为获取所述球囊在所述临界接触时刻的第一液体容量；
    正常血管直径确定单元，设置为根据所述第一液体容量和所述球囊参数确定所述正常血管的直径。
  10. 根据权利要求8或9所述的系统，其中，所述预设扩张规则包括所述待扩张血管的可扩张系数，所述待扩张血管的可扩张系数为所述待扩张血管的扩张直径与所述正常血管直径的比值。
  11. 一种计算机，所述计算机包括：
    至少一个处理器；
    存储器，设置为存储至少一个程序；
    当所述至少一个程序被所述至少一个处理器执行，使得所述至少一个处理器实现如权利要求1-7中任一所述的扩张参数确定方法。
  12. 一种计算机可读存储介质，存储有计算机程序，所述计算机程序被处理器执行时实现如权利要求1-7中任一所述的扩张参数确定方法。
PCT/CN2018/084995 2018-02-12 2018-04-28 扩张参数确定方法、系统、计算机和存储介质 WO2019153539A1 (zh)

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