WO2019151175A1 - Dispositif de manipulation de fluide - Google Patents

Dispositif de manipulation de fluide Download PDF

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Publication number
WO2019151175A1
WO2019151175A1 PCT/JP2019/002678 JP2019002678W WO2019151175A1 WO 2019151175 A1 WO2019151175 A1 WO 2019151175A1 JP 2019002678 W JP2019002678 W JP 2019002678W WO 2019151175 A1 WO2019151175 A1 WO 2019151175A1
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WO
WIPO (PCT)
Prior art keywords
diaphragm
flow path
rotary member
gear
transmission gear
Prior art date
Application number
PCT/JP2019/002678
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English (en)
Japanese (ja)
Inventor
伸也 砂永
Original Assignee
株式会社エンプラス
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Filing date
Publication date
Application filed by 株式会社エンプラス filed Critical 株式会社エンプラス
Publication of WO2019151175A1 publication Critical patent/WO2019151175A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N37/00—Details not covered by any other group of this subclass

Definitions

  • the present invention relates to a fluid handling apparatus for controlling a fluid in a flow path of a flow path chip having a plurality of diaphragms.
  • fluid handling devices have been used to analyze trace substances such as proteins and nucleic acids with high accuracy and high speed.
  • the fluid handling apparatus has the advantage that the amount of reagents and samples required for analysis may be small, and is expected to be used in various applications such as clinical tests, food tests, and environmental tests.
  • a fluid handling device capable of opening and closing a flow path by a rotatable rotary member is known (for example, see Patent Document 1).
  • the fluid handling device described in Patent Document 1 includes a reaction vessel, a first flow channel having one end connected to the reaction vessel, a sealed vessel, a second flow channel having one end connected to the sealed vessel, A liquid syringe and a switching valve for connecting the syringe to the first flow path or the second flow path are included.
  • the switching valve is a rotary rotary member, and the syringe is connected to the first channel or the second channel via the channel in the switching valve by rotating the switching valve. It can be connected to a flow path.
  • Patent Document 1 Since the fluid handling device described in Patent Document 1 can handle only one rotary member (switching valve), the fluid cannot be controlled separately at a plurality of locations.
  • An object of the present invention is to provide a fluid handling apparatus capable of separately controlling fluid at a plurality of locations using a plurality of rotary members.
  • the fluid handling device of the present invention is a fluid handling device for controlling a fluid in a flow channel of a flow channel chip having a first diaphragm and a second diaphragm, and a first convex for pressing the first diaphragm.
  • a second rotary member having a first rotary member that is rotatable about the first rotation axis, a second convex portion for pressing the second diaphragm, and that is rotatable about the second rotation axis.
  • a rotary member; and a rotation switching portion capable of switching between rotation of the first rotary member and rotation of the second rotary member, wherein the first rotation shaft is the first convex portion of the flow path chip. Is substantially perpendicular to the surface against which the second tip rotates, and the second rotation axis is substantially perpendicular to the surface against which the second convex portion of the flow channel tip abuts.
  • fluids in a flow channel chip having a plurality of diaphragms, can be separately controlled at a plurality of locations using a plurality of rotary members.
  • FIG. 1 is a perspective view showing a configuration of a fluid handling apparatus according to Embodiment 1.
  • FIG. 2 is a cross-sectional view showing the configuration of the fluid handling apparatus according to the first embodiment.
  • 3A and 3B are plan views for explaining the operation of the rotation switching unit.
  • 4A to 4C are diagrams showing the configuration of the flow path chip according to the first embodiment.
  • 5A and 5B are schematic diagrams for explaining the operation of the fluid handling apparatus according to Embodiment 1.
  • FIG. FIG. 6 is a plan view showing the configuration of the first rotary member and the second rotary member of the fluid handling apparatus according to Embodiment 2.
  • 7A and 7B are diagrams showing the configuration of the flow path chip according to Embodiment 2.
  • FIG. 8A and 8B are schematic diagrams for explaining the operation of the fluid handling device according to the second embodiment.
  • FIG. 1 is a perspective view showing a configuration of a fluid handling apparatus 100 according to Embodiment 1.
  • FIG. 2 is a cross-sectional view showing the configuration of the fluid handling apparatus 100.
  • the flow channel chip 200 is also illustrated.
  • 3A and 3B are plan views for explaining the operation of the rotation switching unit.
  • the connection member in the upper part of the 1st transmission gear 120 and the 2nd transmission gear 130 is abbreviate
  • the fluid handling apparatus 100 can hold the flow channel chip 200 by a holding unit (not shown), and controls the fluid in the flow channel of the held flow channel chip 200.
  • the fluid handling apparatus 100 includes a rotational power source 110, a first transmission gear 120, a second transmission gear 130, a gear moving unit 140, a first rotary member 150, and a second rotary member 160.
  • the rotational power source 110, the first transmission gear 120, the second transmission gear 130, and the gear moving unit 140 function as a rotation switching unit that can switch between the rotation of the first rotary member 150 and the rotation of the second rotary member 160.
  • each component will be described.
  • Rotational power source 110 is a power source for rotating the first rotary member 150 and the second rotary member 160.
  • the type of the rotational power source 110 is not particularly limited.
  • the rotational power source 110 is a stepping motor that can accurately control the rotation of the first rotary member 150 and the second rotary member 160.
  • a gear 111 is fixed to the rotation shaft of the rotational power source 110.
  • a gear 111a disposed on the lower side for transmitting the driving force to the first rotary member 150 and a gear disposed on the upper side for transmitting the driving force to the second rotary member 160.
  • 111b is fixed to the rotating shaft (see FIG. 1), but the gear 111a and the gear 111b may be integrated.
  • the first transmission gear 120 is a gear for transmitting the driving force from the rotational power source 110 to the first rotary member 150. As shown in FIG. 3A, the first transmission gear 120 meshes simultaneously with a gear 111a fixed to the rotation shaft of the rotational power source 110 and a gear 152 fixed to the rotation shaft of the first rotary member 150. be able to. In this state, when the rotation shaft of the rotational power source 110 rotates, the first rotary member 150 is rotated.
  • the second transmission gear 130 is a gear for transmitting the driving force from the rotational power source 110 to the second rotary member 160. As shown in FIG. 3B, the second transmission gear 130 meshes simultaneously with the gear 111b fixed to the rotation shaft of the rotational power source 110 and the gear 162 fixed to the rotation shaft of the second rotary member 160. be able to. In this state, when the rotation shaft of the rotational power source 110 rotates, the second rotary member 160 is rotated.
  • the gear moving unit 140 moves the first transmission gear 120 and the second transmission gear 130 so that the first rotary member 150 rotates (see FIG. 3A) and the second rotary member 160 rotates in the second state. (See FIG. 3B).
  • the gear moving unit 140 moves the first transmission gear 120 and the second transmission gear 130 to the gear 111 a connected to the rotational power source 110 and the gear 152 connected to the first rotary member 150.
  • the first transmission gear 120 is brought into contact (see FIG. 3A).
  • the second transmission gear 130 is not in contact with at least one of the gear 111 b connected to the rotational power source 110 and the gear 162 connected to the second rotary member 160. Therefore, in the first state, the driving force from the rotational power source 110 is transmitted only to the first rotary member 150, and only the first rotary member 150 rotates.
  • the gear moving unit 140 moves the first transmission gear 120 and the second transmission gear 130 to connect the gear 111b and the second rotary member 160 connected to the rotational power source 110.
  • the second transmission gear 130 is brought into contact with the gear 162 connected to the.
  • the first transmission gear 120 is not in contact with at least one of the gear 111 a connected to the rotational power source 110 and the gear 152 connected to the first rotary member 150. Therefore, in the second state, the driving force from the rotational power source 110 is transmitted only to the second rotary member 160, and only the second rotary member 160 rotates.
  • the gear moving unit 140 includes an actuator 141 and two connecting members 142.
  • the two connecting members 142 are connected to the actuator 141 while holding the first transmission gear 120 and the second transmission gear 130 rotatably.
  • the actuator 141 moves the first transmission gear 120 and the second transmission gear 130 in the horizontal direction via the connecting member 142, so that the first state (see FIG. 3A) and the second state (see FIG. 3B) Switch.
  • the type of the actuator 141 is not particularly limited. In the present embodiment, the actuator 141 is a solenoid actuator.
  • the first rotary member 150 is a member that can rotate around the first rotation axis, and is a first member for pressing the first diaphragm 235 (see FIG. 4) of the flow channel chip 200 against the surface facing the flow channel chip 200.
  • One convex portion 151 is provided.
  • the first rotation axis is substantially perpendicular to the surface with which the first convex portion 151 of the flow channel chip 200 abuts.
  • the main body portion of the first rotary member 150 has a columnar shape, and the first convex portion 151 is disposed on the top surface of the column.
  • a gear 152 is fixed to the rotation shaft of the first rotary member 150.
  • the number and shape of the first protrusions 151 are appropriately set according to the configuration of the flow path chip 200.
  • the first protrusion 151 is one protrusion that extends along the rotation direction of the first rotary member 150. More specifically, the first convex portion 151 extends in an arc shape, but has a notch at a specific position (right side position in FIG. 3A).
  • the second rotary member 160 is a member that can rotate around the second rotation axis separately from the first rotary member 150, and has a second diaphragm 251 ( It has the 2nd convex part 161 for pressing (refer FIG. 4).
  • the second rotation axis is substantially perpendicular to the surface with which the second convex portion 161 of the flow channel chip 200 abuts.
  • the first rotation axis and the second rotation axis coincide. That is, the first rotary member 150 and the second rotary member 160 rotate about the same axis.
  • the main-body part of the 1st rotary member 150 is carrying out the cylindrical shape surrounding the main-body part of the 1st rotary member 150, and the 2nd convex part 161 is on the top
  • a gear 162 is fixed to the second rotary member 160.
  • the number and shape of the second convex portions 161 are appropriately set according to the configuration of the flow path chip 200.
  • the second convex portion 161 is one convex portion that is shorter than the first convex portion 151. More specifically, the 2nd convex part 161 is arrange
  • the material of the first rotary member 150 and the second rotary member 160 is not particularly limited as long as it has a certain degree of rigidity, and can be appropriately selected from known materials.
  • Examples of the material of the first rotary member 150 and the second rotary member 160 include resin, rubber, and metal.
  • the material of the first rotary member 150 and the second rotary member 160 is preferably, for example, polyethylene.
  • the surface of the first rotary member 150 and the second rotary member 160 (particularly the surfaces of the first convex portion 151 and the second convex portion 161) is subjected to a coating process for improving the slidability with respect to the flow channel chip 200. May be.
  • the fluid handling apparatus 100 can hold the flow channel chip 200 by a holding unit (not shown), and controls the fluid in the flow channel of the held flow channel chip 200. More specifically, the flow channel chip 200 has a plurality of diaphragms, and the fluid handling apparatus 100 presses the diaphragm with the first convex portion 151 and the second convex portion 161, whereby the flow channel chip 200. The fluid in the flow path is controlled.
  • FIG. 4A to 4C are diagrams showing the configuration of the flow path chip 200 according to Embodiment 1.
  • FIG. 4A is a bottom view of the flow channel chip 200
  • FIG. 4B is a cross-sectional view taken along the line BB shown in FIG. 4A
  • FIG. 4C is a cross-sectional view taken along the line CC shown in FIG. 4A. is there.
  • FIG. 4A grooves (flow paths) and through holes (such as accommodation portions) formed in the substrate 210 that are hidden behind the film 220 and are not visible are indicated by broken lines.
  • the flow channel chip 200 has a substrate 210 and a film 220.
  • the film 220 is bonded to one surface of the substrate 210 so as to close the grooves formed in the substrate 210 and the openings of the through holes.
  • a partial area of the film 220 functions as a diaphragm.
  • the groove of the substrate 210 closed by the film 220 serves as a flow path for flowing a fluid such as a reagent, a liquid sample, gas, and powder.
  • the thickness of the substrate 210 is not particularly limited.
  • the thickness of the substrate 210 is 1 mm or more and 10 mm or less.
  • the material of the substrate 210 is not particularly limited.
  • the material of the substrate 210 can be appropriately selected from known resins and glasses. Examples of the material of the substrate 210 include polyethylene terephthalate, polycarbonate, polymethyl methacrylate, polyvinyl chloride, polypropylene, polyether, polyethylene, polystyrene, silicone resin, and elastomer.
  • the thickness of the film 220 is not particularly limited as long as it can function as a diaphragm.
  • the thickness of the film 220 is 30 ⁇ m or more and 300 ⁇ m or less.
  • the material of the film 220 is not particularly limited.
  • the material of the film 220 can be appropriately selected from known resins. Examples of the material of the film 220 include polyethylene terephthalate, polycarbonate, polymethyl methacrylate, polyvinyl chloride, polypropylene, polyether, polyethylene, polystyrene, silicone resin, and elastomer.
  • the film 220 is bonded to the substrate 210 by, for example, heat welding, laser welding, adhesive, or the like.
  • the flow channel chip 200 includes three flow channel units 230a to 230c, one second accommodating portion 240, and one diaphragm pump 250.
  • Each of the three flow path units 230a to 230c has a diaphragm valve.
  • the three flow path units 230a to 230c have the same structure although their positions are different. Therefore, only the flow path unit 230a will be described, and description of the flow path unit 230b and the flow path unit 230c will be omitted.
  • the flow path unit 230a includes a first accommodating portion 231, a first flow path 232, a partition wall 233, a second flow path 234, and a first diaphragm 235.
  • the partition wall 233 and the first diaphragm 235 function as a diaphragm valve positioned between the first flow path 232 and the second flow path 234.
  • the 1st accommodating part 231 is a bottomed recessed part for accommodating a fluid.
  • the first housing portion 231 is configured by a through hole formed in the substrate 210 and a film 220 that closes one opening of the through hole.
  • the shape and size of the first housing portion 231 are not particularly limited, and can be appropriately set as necessary.
  • the shape of the 1st accommodating part 231 is a substantially cylindrical shape, for example.
  • variety of the 1st accommodating part 231 is about 2 mm, for example.
  • the fluid that can be accommodated in the first accommodating portion 231 can be appropriately selected according to the application of the flow channel chip 200.
  • the fluid is a fluid such as a reagent, a liquid sample, or a powder.
  • the first channel 232 is a channel through which fluid can move.
  • the upstream end of the first flow path 232 is connected to the first housing portion 231.
  • a partition wall 233 is disposed at the downstream end of the first flow path 232.
  • the first flow path 232 includes a groove formed in the substrate 210 and a film 220 that closes the opening of the groove.
  • the cross-sectional area and the cross-sectional shape of the first flow path 232 are not particularly limited.
  • the “cross section of the flow path” means a cross section of the flow path perpendicular to the direction in which the fluid flows.
  • the cross-sectional shape of the first flow path 232 is, for example, a substantially rectangular shape having a side length (width and depth) of about several tens of ⁇ m.
  • the cross-sectional area of the first flow path 232 may or may not be constant in the fluid flow direction. In the present embodiment, the cross-sectional area of the first flow path 232 is constant.
  • the partition wall 233 is a wall disposed between the downstream end of the first flow path 232 and the upstream end of the second flow path 234.
  • the partition wall 233 functions as a valve seat of a diaphragm valve for opening and closing between the first flow path 232 and the second flow path 234.
  • the shape and height of the partition wall 223 are not particularly limited as long as the above functions can be exhibited.
  • the shape of the partition wall 233 is, for example, a quadrangular prism shape.
  • the height of the partition wall 233 is, for example, the same as the depth of the first channel 232 and the second channel 234.
  • the second channel 234 is a channel through which fluid can move. More specifically, the second channel 234 is a channel through which the fluid that has moved from the first channel 232 flows through a gap between the partition wall 233 and the diaphragm 235. A partition wall 233 is disposed at the upstream end of the second flow path 234. The downstream end of the second flow path 234 merges with the downstream end of the second flow path 234 of the other flow path units 230b and 230c, and is connected to the second accommodating portion 240.
  • the second flow path 234 includes a groove formed in the substrate 210 and a film 220 that closes the opening of the groove.
  • the cross-sectional area and cross-sectional shape of the second flow path 234 are the same as the cross-sectional area and cross-sectional shape of the first flow path 232.
  • the first diaphragm 235 is a part of the flexible film 220 and has a substantially spherical crown shape.
  • the film 220 is disposed on the substrate 210 so that the first diaphragm 235 is not in contact with and faces the partition wall 233.
  • the first diaphragm 235 bends toward the partition wall 233 when pressed by the first convex portion 151 of the first rotary member 150. That is, the 1st diaphragm 235 functions as a valve body of a diaphragm valve.
  • the first flow path 232 and the second flow path 234 are in communication with each other via the gap between the first diaphragm 235 and the partition wall 233.
  • the 1st convex part 151 is pressing the 1st diaphragm 235 so that the 1st diaphragm 235 may contact the partition 233, the 1st flow path 232 and the 2nd flow path 234 will be in the state which does not mutually communicate.
  • the distance between the first diaphragm 235 and the partition wall 233 can be set as appropriate from the viewpoint of the flow rate of a desired fluid, the ease of close contact between the first diaphragm 235 and the partition wall 233, and the like.
  • the second accommodating portion 240 is a space for accommodating a fluid therein.
  • the second accommodating portion 240 is composed of a recess formed in the substrate 210 and a film 220 that closes the opening of the recess.
  • the shape of the 2nd accommodating part 240 is a substantially hexagonal column shape, for example.
  • the upstream end of the second accommodating portion 240 is connected to the downstream end of the second flow path 234 in the three flow path units 230a to 230c.
  • the downstream end of the second housing part 240 is connected to the diaphragm pump 250.
  • the cross-sectional area and the cross-sectional shape of the second housing part 240 are not particularly limited, and can be appropriately adjusted according to the application.
  • the fluid stored in the second storage unit 240 can be appropriately set according to the use of the flow path chip 200.
  • the second storage unit 240 can be used as a chamber for mixing fluid from the first storage unit 231 in the three flow path units 230a to 230c.
  • the size of the second accommodating portion 240 has a sufficient volume for accommodating the fluid from the first accommodating portion 231 in the three flow path units 230a to 230c.
  • the diaphragm pump 250 has a second diaphragm 251 and a discharge port 252.
  • the second diaphragm 251 is a part of the flexible film 220 and protrudes on the side opposite to the substrate 210.
  • the planar view shape of the second diaphragm 251 is a substantially arc shape.
  • the upstream end of the second diaphragm 251 faces the second housing part 240 or a part of the flow path connected to the second housing part 240.
  • the downstream end of the second diaphragm 251 faces the discharge port 252 or a part of the flow path connected to the discharge port 252.
  • the other part of the second diaphragm 251 is disposed so as to face the surface of the substrate 210 where the groove and the through hole are not formed.
  • the film 220 is disposed on the substrate 210 so that the second diaphragm 251 faces both the surface of the substrate 210 where the flow path is not formed and a part of the flow path.
  • the second diaphragm 251 is arranged so that the second convex portion 161 of the second rotary member 160 can move on the second diaphragm 251 while pressing the second diaphragm 251.
  • the second diaphragm 251 bends toward the substrate 210 when pressed by the second convex portion 161.
  • the width of the second diaphragm 251 and the distance between the second diaphragm 251 and the substrate 210 can be adjusted as appropriate from the viewpoint of the desired flow rate of the fluid, the ease of adhesion between the second diaphragm 251 and the substrate 210, and the like. The larger these are, the larger the amount of fluid movement when the second convex portion 161 is moved, and the smaller these are, the easier it is to bring the second diaphragm 251 and the substrate 210 into close contact with each other.
  • the discharge port 252 is a bottomed recess that is connected to the downstream end of the space (flow path) between the substrate 210 and the second diaphragm 251 and is open to the outside.
  • the discharge port 252 includes a through hole formed in the substrate 210 and a film 220 that closes one opening of the through hole.
  • the shape and size of the discharge port 252 are not particularly limited, and can be appropriately designed as necessary.
  • the shape of the discharge port 252 is, for example, a substantially cylindrical shape.
  • the width of the discharge port 252 is, for example, about 2 mm.
  • the second diaphragm 251 is arranged so that the second convex portion 161 of the second rotary member 160 can move on the second diaphragm 251 while pressing the second diaphragm 251.
  • the second convex portion 161 moves on the second diaphragm 251 from the second accommodating portion 240 side toward the discharge port 252 side while pressing the second diaphragm 251
  • a space between the substrate 210 and the second diaphragm 251 ( The fluid in the flow path) is pushed out toward the discharge port 252 and the pressure in the second accommodating portion 240 decreases.
  • the fluid moves from the flow path units 230a to 230c whose diaphragm valves are open into the second accommodating portion 240. That is, the diaphragm pump 250 functions as a pump that moves the fluid from the flow path units 230a to 230c in which the diaphragm valve is open among the three flow path units 230a to 230c into the second accommodating portion 240.
  • FIG. 5A and 5B are schematic diagrams for explaining the operation of the fluid handling apparatus 100.
  • FIG. In these drawings the first convex portion 151 of the first rotary member 150 and the second convex portion 161 of the second rotary member 160 of the fluid handling device 100, the first diaphragm 235 and the second diaphragm 251 of the flow channel chip 200, and The positional relationship is shown.
  • a predetermined fluid is previously stored in each of the first storage portions 231 of the three flow path units 230a to 230c.
  • tip 200 is set to the predetermined position (above the 1st rotary member 150 and the 2nd rotary member 160) of the fluid handling apparatus 100 (refer FIG. 2). Accordingly, the first convex portion 151 of the first rotary member 150 and the second convex portion 161 of the second rotary member 160 are in contact with the film 220 of the flow path chip 200. Another film or the like may be disposed between the first rotary member 150 and the second rotary member 160 and the film 220.
  • the gear moving unit 140 moves the first transmission gear 120 and the second transmission gear 130, and the gear 111a connected to the rotational power source 110 and the gear 152 connected to the first rotary member 150.
  • the first transmission gear 120 is brought into contact with (first state: see FIG. 3A).
  • the rotational power source 110 rotates the first rotary member 150 until the notch of the first convex portion 151 is positioned on the first diaphragm 235 of the flow path unit 230a (see FIG. 5A).
  • the diaphragm valve of the flow path unit 230a is opened, and the first storage portion 231 and the second storage portion 240 of the flow path unit 230a communicate with each other.
  • the first diaphragm 235 of the flow path unit 230b and the first diaphragm 235 of the flow path unit 230c are pressed by the first convex portion 151 (see FIG. 5A). Therefore, the diaphragm valves of the flow path unit 230b and the flow path unit 230c are closed, and the first storage portion 231 of the flow path unit 230b and the first storage portion 231 and the second storage portion 240 of the flow path unit 230c communicate with each other. It will be in a state that does not.
  • the gear moving unit 140 moves the first transmission gear 120 and the second transmission gear 130, and the gear 111b connected to the rotational power source 110 and the gear 162 connected to the second rotary member 160.
  • 2nd transmission gear 130 is made to contact (2nd state: refer to Drawing 3B).
  • the rotational power source 110 rotates the second rotary member 160 so that the second convex portion 161 moves counterclockwise along the second diaphragm 251 (see FIG. 5A).
  • the inside of the 2nd accommodating part 240 becomes a negative pressure, and at least a part of fluid in the 1st accommodating part 231 of channel unit 230a moves into the 2nd accommodating part 240.
  • the gear moving unit 140 moves the first transmission gear 120 and the second transmission gear 130, and the gear 111a connected to the rotational power source 110 and the gear 152 connected to the first rotary member 150.
  • the first transmission gear 120 is brought into contact with (first state: see FIG. 3A).
  • the rotational power source 110 rotates the first rotary member 150 until the notch of the first convex portion 151 is positioned on the first diaphragm 235 of the flow path unit 230b (see FIG. 5B).
  • the diaphragm valve of the flow path unit 230b is opened, and the first storage portion 231 and the second storage portion 240 of the flow path unit 230b communicate with each other.
  • the gear moving unit 140 moves the first transmission gear 120 and the second transmission gear 130, and the gear 111b connected to the rotational power source 110 and the gear 162 connected to the second rotary member 160.
  • 2nd transmission gear 130 is made to contact (2nd state: refer to Drawing 3B).
  • the rotational power source 110 rotates the second rotary member 160 so that the second convex portion 161 moves counterclockwise along the second diaphragm 251 (see FIG. 5B).
  • the inside of the 2nd storage part 240 becomes a negative pressure, and at least a part of fluid in the 1st storage part 231 of channel unit 230b moves in the 2nd storage part 240.
  • the fluid stored in the first storage part 231 of the flow path unit 230a and the fluid stored in the first storage part 231 of the flow path unit 230b are mixed. Is done.
  • the fluid handling apparatus 100 can complexly control the fluid in the flow channel chip 200 by separately rotating the first rotary member 150 and the second rotary member 160. it can.
  • the fluid handling apparatus can hold the flow channel chip 400 by the holding unit, and controls the fluid in the flow channel of the held flow channel chip 400.
  • the fluid handling apparatus according to the second embodiment includes a rotational power source 110, a first transmission gear 120, a second transmission gear 130, a gear moving unit 140, a first rotary member 350, and a second rotary member 360 (FIG. 1 to FIG. 1). (See FIG. 3B).
  • the rotational power source 110, the first transmission gear 120, the second transmission gear 130, and the gear moving unit 140 function as a rotation switching unit that can switch between the rotation of the first rotary member 350 and the rotation of the second rotary member 360.
  • the first rotary member 350 and the second rotary member 360 different from the fluid handling apparatus 100 according to Embodiment 1 will be described.
  • FIG. 6 is a plan view showing the configuration of the main body portion of the first rotary member 350 and the main body portion of the second rotary member 360 of the fluid handling apparatus according to the second embodiment.
  • the first convex portion 351 (the top surface) and the second convex portion 361 (the top surface) are hatched.
  • the first rotary member 350 is a member that can rotate about the first rotation axis, and a first convex portion for pressing the first diaphragm 454 (see FIG. 7) of the accommodation units 450a to 450c of the flow channel chip 400.
  • 351 is provided on the surface facing the flow channel chip 400.
  • the first rotation axis is substantially perpendicular to the surface with which the first convex portion 351 of the flow channel chip 400 abuts.
  • the main body portion of the first rotary member 350 has a cylindrical shape, and the first convex portion 351 is disposed on the top surface of the column.
  • a gear 152 is fixed to the rotation shaft of the first rotary member 350 (see FIG. 2).
  • the number and shape of the first convex portions 351 are appropriately set according to the configuration of the flow path chip 400.
  • the first convex portion 351 is one convex line extending along the rotation direction of the first rotary member 350. More specifically, the first convex portion 351 extends in an arc shape, but has a notch at a specific position (upper position in FIG. 6).
  • the second rotary member 360 is a member that is rotatable about the second rotation axis, separately from the first rotary member 350, and the first diaphragm 434 of the introduction units 430a to 430c of the flow channel chip 400 (see FIG. 7). ) On the surface facing the flow channel chip 400.
  • the second rotation axis is substantially perpendicular to the surface with which the second convex portion 361 of the flow channel chip 400 abuts.
  • the first rotation axis and the second rotation axis coincide. That is, the first rotary member 350 and the second rotary member 360 rotate about the same axis.
  • the main body portion of the first rotary member 350 has a cylindrical shape surrounding the main body portion of the first rotary member 350, and the second convex portion 361 is formed on the top surface (end surface) of the cylinder. Has been placed.
  • a gear 162 is fixed to the second rotary member 360 (see FIG. 2).
  • the number and shape of the second convex portions 361 are appropriately set according to the configuration of the flow path chip 400.
  • the second convex part 361 is one convex line extending along the rotation direction of the second rotary member 360. More specifically, the second convex portion 361 extends in an arc shape, but has a notch at a specific position (the upper position in FIG. 6).
  • the fluid handling apparatus can hold the flow channel chip 400 by the holding unit and controls the fluid in the flow channel of the held flow channel chip 400.
  • the channel chip 400 has a plurality of diaphragms, and the fluid handling device according to the second embodiment presses the diaphragm with the first convex portion 351 and the second convex portion 361. The fluid in the flow channel of the flow channel chip 400 is controlled.
  • FIG. 7A and 7B are diagrams showing the configuration of the flow path chip 400 according to the second embodiment.
  • 7A is a bottom view of the channel chip 400
  • FIG. 7B is a cross-sectional view taken along the line BB shown in FIG. 7A.
  • grooves (flow paths) and through holes (such as accommodation portions) formed in the substrate 410 that are hidden behind the film 420 and are not visible are indicated by broken lines.
  • the flow channel chip 400 includes a substrate 410 and a film 420.
  • the substrate 410 grooves and through holes are appropriately formed within a range in which the effects of the present embodiment can be obtained.
  • the film 420 is bonded to one surface of the substrate 410 so as to close the groove formed in the substrate 410 and the opening of the through hole. A part of the film 420 functions as a diaphragm.
  • the groove of the substrate 410 closed by the film 420 serves as a flow path for flowing a fluid such as a reagent, a liquid sample, gas, and powder.
  • the thickness and material of the substrate 410 are not particularly limited. Examples of the thickness and material of the substrate 410 are the same as those of the substrate 210 of the flow path chip 200 according to Embodiment 1.
  • the thickness and material of the film 420 are not particularly limited as long as it can function as a diaphragm. Examples of the thickness and material of the film 420 are the same as those of the substrate 220 of the flow path chip 200 according to Embodiment 1.
  • the film 420 is bonded to the substrate 410 by, for example, heat welding, laser welding, adhesive, or the like.
  • the flow path chip 400 includes three introduction units 430a to 430c, one flow path 440, and three accommodation units 450a to 450c.
  • Each of the three introduction units 430a to 430c and the three accommodation units 450a to 450c has a diaphragm valve.
  • the three introduction units 430a to 430c have the same structure although their positions are different. Therefore, only the introduction unit 430a will be described, and description of the introduction unit 430b and the introduction unit 430c will be omitted.
  • the introduction unit 430a has an introduction port 431, a connection flow path 432, a partition wall 433, and a first diaphragm 434.
  • the partition wall 433 and the first diaphragm 434 function as a diaphragm valve positioned between the connection channel 432 (first channel in the claims) and the channel 440 (second channel in the claims). .
  • the introduction port 431 is a bottomed recess for accommodating a fluid.
  • the introduction port 431 includes a through hole formed in the substrate 410 and a film 420 that closes one opening of the through hole.
  • the shape and size of the introduction port 431 are not particularly limited, and can be appropriately set as necessary.
  • the shape of the introduction port 431 is, for example, a substantially cylindrical shape.
  • the width of the introduction port 431 is, for example, about 2 mm.
  • the fluid that can be accommodated in the introduction port 431 can be appropriately selected according to the use of the flow path chip 400.
  • the fluid is a fluid such as a reagent, a liquid sample, or a powder.
  • connection channel 432 is a channel through which fluid can move.
  • the upstream end of the connection channel 432 is connected to the introduction port 431.
  • a partition wall 433 is disposed at the downstream end of the connection channel 432.
  • the connection flow path 432 includes a groove formed in the substrate 410 and a film 420 that closes the opening of the groove.
  • the cross-sectional area and the cross-sectional shape of the connection channel 432 are not particularly limited.
  • the cross-sectional shape of the connection channel 432 is, for example, a substantially rectangular shape having a side length (width and depth) of about several tens of ⁇ m.
  • the cross-sectional area of the connection channel 432 may or may not be constant in the fluid flow direction. In the present embodiment, the cross-sectional area of the connection channel 432 is constant.
  • the partition wall 433 is a wall disposed between the downstream end of the connection channel 432 and the channel 440.
  • the partition wall 433 functions as a valve seat of a diaphragm valve for opening and closing between the connection channel 432 and the channel 440.
  • the shape and height of the partition wall 433 are not particularly limited as long as the above functions can be exhibited.
  • the shape of the partition wall 433 is, for example, a quadrangular prism shape.
  • the height of the partition wall 433 is, for example, the same as the depth of the connection channel 432 and the channel 440.
  • the first diaphragm 434 is a part of the flexible film 420 and has a substantially spherical crown shape.
  • the film 420 is disposed on the substrate 410 so that the first diaphragm 434 faces the partition wall 433 without contact.
  • the first diaphragm 434 bends toward the partition 433 when pressed by the second convex portion 361 of the second rotary member 360. That is, the 1st diaphragm 434 functions as a valve body of a diaphragm valve.
  • the connection channel 432 and the channel 440 are in communication with each other through the gap between the first diaphragm 434 and the partition wall 433.
  • connection flow path 432 and the flow path 440 will be in the state which does not mutually communicate.
  • the distance between the first diaphragm 434 and the partition wall 433 can be set as appropriate from the viewpoint of the flow rate of a desired fluid, the ease of close contact between the first diaphragm 434 and the partition wall 433, and the like.
  • the flow path 440 is a flow path through which fluid can move. More specifically, the flow path 440 is a flow path in which the fluid that has moved from any of the three introduction units 430a to 430c flows to any of the three accommodation units 450a to 450c.
  • the flow path 440 includes a groove formed in the substrate 410 and a film 420 that closes the opening of the groove.
  • the cross-sectional area and cross-sectional shape of the flow path 440 are the same as the cross-sectional area and cross-sectional shape of the connection flow path 432.
  • the channel 440 includes an arc-shaped channel, a circular channel disposed inside the arc-shaped channel so as to be concentric with the arc-shaped channel, and these And a linear flow path connecting the two.
  • the outer arc-shaped channel is connected to the three introduction units 430a to 430c
  • the inner circular channel is connected to the three accommodating units 450a to 450c.
  • the flow path 440 functions as a flow path on the downstream side of the diaphragm valve (second flow path in the claims).
  • the channel 440 functions as a channel on the upstream side of the diaphragm valve (first channel in the claims).
  • the three housing units 450a to 450c have the same structure although their positions are different. Therefore, only the storage unit 450a will be described, and description of the storage unit 450b and the storage unit 450c will be omitted.
  • the housing unit 450 a includes a housing portion 451, a connection channel 452, a partition wall 453, and a first diaphragm 454.
  • the partition wall 453 and the first diaphragm 454 function as a diaphragm valve positioned between the flow path 440 (first flow path in the claims) and the connection flow path 452 (second flow path in the claims). .
  • the accommodating part 451 is a bottomed recessed part for accommodating a fluid.
  • the housing portion 451 is composed of a through-hole formed in the substrate 410 and a film 420 that closes one opening of the through-hole.
  • the shape and size of the accommodating portion 451 are not particularly limited, and can be appropriately set as necessary.
  • the shape of the accommodating part 451 is, for example, a substantially cylindrical shape.
  • the width of the accommodating part 451 is, for example, about 2 mm.
  • the fluid accommodated in the accommodating portion 451 can be appropriately set according to the use of the flow path chip 400.
  • the accommodating portion 451 can be used as a chamber for mixing fluid from the introduction port 431 in the three introduction units 430a to 430c.
  • the size of the accommodating portion 451 preferably has a volume sufficient to accommodate the fluid from the inlet 431 in the three introducing units 430a to 430c.
  • connection channel 452 is a channel through which fluid can move.
  • a partition wall 453 is disposed at the upstream end of the connection channel 452.
  • the downstream end of the connection channel 452 is connected to the housing portion 451.
  • the connection flow path 432 includes a groove formed in the substrate 410 and a film 420 that closes the opening of the groove.
  • the cross-sectional area and cross-sectional shape of the flow path 440 are the same as the cross-sectional area and cross-sectional shape of the connection flow path 432.
  • the partition wall 453 is a wall disposed between the flow path 440 and the upstream end of the connection flow path 452.
  • the partition wall 453 functions as a valve seat of a diaphragm valve for opening and closing between the flow path 440 and the connection flow path 452.
  • the shape and height of the partition wall 453 are the same as the shape and height of the partition wall 433.
  • the first diaphragm 454 is a part of the flexible film 420 and has a substantially spherical crown shape.
  • the film 420 is disposed on the substrate 410 so that the first diaphragm 454 faces the partition wall 453 without contact.
  • the first diaphragm 454 bends toward the partition 453 when pressed by the first convex portion 351 of the first rotary member 350. That is, the 1st diaphragm 454 functions as a valve body of a diaphragm valve.
  • the flow path 440 and the connection flow path 452 are in communication with each other via the gap between the first diaphragm 454 and the partition wall 453.
  • the distance between the first diaphragm 454 and the partition 453 can be set as appropriate from the viewpoint of the flow rate of a desired fluid, the ease of close contact between the first diaphragm 454 and the partition 453, and the like.
  • FIG. 8A and 8B are schematic diagrams for explaining the operation of the fluid handling apparatus according to Embodiment 2.
  • FIG. In these drawings the first convex portion 351 of the first rotary member 350 and the second convex portion 361 of the second rotary member 360 of the fluid handling device, and the first diaphragm 434 and the first diaphragm 454 of the flow channel chip 400 are shown. The positional relationship is shown.
  • a predetermined fluid is previously stored in each of the introduction ports 431 of the three introduction units 430a to 430c.
  • tip 400 is set to the predetermined position (above the 1st rotary member 350 and the 2nd rotary member 360) of a fluid handling apparatus (refer FIG. 2).
  • the first convex portion 351 of the first rotary member 350 and the second convex portion 361 of the second rotary member 360 abut on the film 420 of the flow path chip 400.
  • another film or the like may be disposed between the first rotary member 350 and the second rotary member 360 and the film 420.
  • the gear moving unit 140 moves the first transmission gear 120 and the second transmission gear 130 to shift the gear 111b connected to the rotational power source 110 and the gear 162 connected to the second rotary member 360.
  • 2nd transmission gear 130 is made to contact (2nd state: refer to Drawing 3B).
  • the rotational power source 110 rotates the second rotary member 360 until the notch of the second convex portion 361 is positioned on the first diaphragm 434 of the introduction unit 430a (see FIG. 8A).
  • the diaphragm valve of the introduction unit 430a is opened, and the introduction port 431 and the flow path 440 of the introduction unit 430a communicate with each other.
  • the first diaphragm 434 of the introduction unit 430b and the first diaphragm 434 of the introduction unit 430c are pressed by the second convex portion 361 (see FIG. 8A). Therefore, the diaphragm valves of the introduction unit 430b and the introduction unit 430c are closed, and the introduction port 431 of the introduction unit 430b, the introduction port 431 of the introduction unit 430c, and the flow path 440 are not communicated.
  • the gear moving unit 140 moves the first transmission gear 120 and the second transmission gear 130, and the gear 111a connected to the rotational power source 110 and the gear 152 connected to the first rotary member 350.
  • the first transmission gear 120 is brought into contact with (first state: see FIG. 3A).
  • the rotational power source 110 rotates the first rotary member 350 until the notch of the first convex portion 351 is positioned on the first diaphragm 454 of the housing unit 450a (see FIG. 8A).
  • the diaphragm valve of the storage unit 450a is opened, and the storage portion 451 of the storage unit 450a and the flow path 440 communicate with each other.
  • the first diaphragm 454 of the housing unit 450b and the first diaphragm 454 of the housing unit 450c are pressed by the first convex portion 351 (see FIG. 8A). For this reason, the diaphragm valves of the housing unit 450b and the housing unit 450c are closed, and the housing portion 451 of the housing unit 450b, the housing portion 451 of the housing unit 450c, and the flow path 440 are not communicated.
  • the inside of the introduction port 431 of the introduction unit 430a is pressurized or the inside of the accommodation portion 451 of the accommodation unit 450a.
  • the pressure is reduced, the fluid accommodated in the introduction port 431 of the introduction unit 430a moves into the accommodation portion 451 of the accommodation unit 450a (see FIG. 8A).
  • the gear moving unit 140 moves the first transmission gear 120 and the second transmission gear 130 to shift the gear 111b connected to the rotational power source 110 and the gear 162 connected to the second rotary member 360.
  • 2nd transmission gear 130 is made to contact (2nd state: refer to Drawing 3B).
  • the rotational power source 110 rotates the second rotary member 360 until the notch of the second convex portion 361 is positioned on the first diaphragm 434 of the introduction unit 430b (see FIG. 8B).
  • the diaphragm valve of the introduction unit 430b is opened, and the introduction port 431 and the flow path 440 of the introduction unit 430b communicate with each other.
  • the first diaphragm 434 of the introduction unit 430a and the first diaphragm 434 of the introduction unit 430c are pressed by the second convex portion 361 (see FIG. 8B). Therefore, the diaphragm valves of the introduction unit 430a and the introduction unit 430c are closed, and the introduction port 431 of the introduction unit 430a, the introduction port 431 of the introduction unit 430c, and the flow path 440 are not communicated.
  • the gear moving unit 140 moves the first transmission gear 120 and the second transmission gear 130, and the gear 111a connected to the rotational power source 110 and the gear 152 connected to the first rotary member 350.
  • the first transmission gear 120 is brought into contact with (first state: see FIG. 3A).
  • the rotational power source 110 rotates the first rotary member 350 until the notch of the first convex portion 351 is positioned on the first diaphragm 454 of the housing unit 450b (see FIG. 8B).
  • the diaphragm valve of the storage unit 450b is opened, and the storage portion 451 of the storage unit 450b and the flow path 440 communicate with each other.
  • the first diaphragm 454 of the housing unit 450a and the first diaphragm 454 of the housing unit 450c are pressed by the first convex portion 351 (see FIG. 8B). For this reason, the diaphragm valves of the housing unit 450a and the housing unit 450c are closed, and the housing portion 451 of the housing unit 450a and the housing portion 451 of the housing unit 450c are not in communication with the flow path 440.
  • the inside of the introduction port 431 of the introduction unit 430b is pressurized or the inside of the accommodation portion 451 of the accommodation unit 450b.
  • the pressure is reduced, the fluid accommodated in the introduction port 431 of the introduction unit 430b moves into the accommodation portion 451 of the accommodation unit 450b (see FIG. 8B).
  • the fluid handling apparatus can complexly control the fluid in the flow channel chip 400 by separately rotating the first rotary member 350 and the second rotary member 360. .
  • the first rotary member 150 controls the opening and closing of the diaphragm valve of the flow channel chip 200 and the second rotary member 160 controls the driving of the diaphragm pump of the flow channel chip 200
  • the second rotary member 360 controls the opening and closing of the diaphragm valve of the flow channel chip 400
  • the present invention is not limited to this.
  • the first rotary member may control the driving of the diaphragm pump of the flow path chip
  • the second rotary member may control the opening and closing of the diaphragm valve of the flow path chip.
  • the first rotary member and the second rotary member may control the driving of the diaphragm pump of the flow path chip.
  • the fluid handling apparatus having the first transmission gear 120 for the first rotary members 150 and 350 and the second transmission gear 130 for the second rotary members 160 and 360 will be described.
  • the number of transmission gears that transmit the driving force of the rotational power source 110 to the first rotary members 150 and 350 and the second rotary members 160 and 360 may be one.
  • the transmission gear contacts the gear 111a connected to the rotational power source 110 and the gear 152 connected to the first rotary members 150 and 350, and in the second state, the transmission gear rotates.
  • the gear 111b connected to the power source 110 and the gear 162 connected to the second rotary members 160 and 360 are contacted.
  • the fluid handling device of the present invention is useful in various applications such as clinical tests, food tests, and environmental tests.
  • Fluid handling apparatus 110 Rotation power source 111, 111a, 111b Gear fixed to the rotating shaft of a rotation power source 120 1st transmission gear 130 2nd transmission gear 140 Gear moving part 141 Actuator 142 Connecting member 150, 350 1st rotary Members 151, 351 First convex portion 152 Gear fixed to the rotation shaft of the first rotary member 160, 360 Second rotary member 161, 361 Second convex portion 162 Gear fixed to the rotation shaft of the second rotary member 200, 400 Channel chip 210, 410 Substrate 220, 420 Film 230a-c Channel unit 231 1st accommodating part 232 1st channel 233 Partition 234 2nd channel 235 1st diaphragm 240 2nd accommodating part 250 Diaphragm pump 251 Second diaphragm 252 Exhaust Mouth 430a ⁇ c introduction unit 431 inlet 432 connecting flow path 433 partition wall 434 first diaphragm 440 flow paths 450a ⁇

Abstract

L'invention concerne un dispositif de manipulation de fluide qui commande un fluide dans un trajet d'écoulement dans une puce à trajet d'écoulement possédant un premier diaphragme et un second diaphragme. Ledit dispositif de manipulation de fluide comprend : un premier élément rotatif présentant une première saillie permettant de presser le premier diaphragme ; un second élément rotatif présentant une seconde saillie permettant de presser le second diaphragme ; et une partie de commutation de rotation permettant de commuter entre la rotation du premier élément rotatif et la rotation du second élément rotatif.
PCT/JP2019/002678 2018-02-01 2019-01-28 Dispositif de manipulation de fluide WO2019151175A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018016708A JP2019132775A (ja) 2018-02-01 2018-02-01 流体取扱装置
JP2018-016708 2018-02-01

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WO2019151175A1 true WO2019151175A1 (fr) 2019-08-08

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US20240093683A1 (en) * 2021-01-22 2024-03-21 Enplas Corporation Fluid handling system
US20240082837A1 (en) * 2021-02-02 2024-03-14 Enplas Corporation Handling device and fluid handling system

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004270935A (ja) * 2003-02-19 2004-09-30 Kawamura Inst Of Chem Res マイクロ流体素子、押圧機構、および流量調節方法
JP2007085537A (ja) * 2005-08-23 2007-04-05 Seiko Instruments Inc マイクロバルブユニット
JP2016536619A (ja) * 2014-09-15 2016-11-24 ユニスト（ウルサン ナショナル インスティテュート オブ サイエンス アンド テクノロジー） 微細流動装置および微細流動装置の制御設備

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004270935A (ja) * 2003-02-19 2004-09-30 Kawamura Inst Of Chem Res マイクロ流体素子、押圧機構、および流量調節方法
JP2007085537A (ja) * 2005-08-23 2007-04-05 Seiko Instruments Inc マイクロバルブユニット
JP2016536619A (ja) * 2014-09-15 2016-11-24 ユニスト（ウルサン ナショナル インスティテュート オブ サイエンス アンド テクノロジー） 微細流動装置および微細流動装置の制御設備

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