WO2019122407A3 - Behandlungsaspekte zur reduzierung des kohlendioxidgehalts im blut - Google Patents

Behandlungsaspekte zur reduzierung des kohlendioxidgehalts im blut Download PDF

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Publication number
WO2019122407A3
WO2019122407A3 PCT/EP2018/086750 EP2018086750W WO2019122407A3 WO 2019122407 A3 WO2019122407 A3 WO 2019122407A3 EP 2018086750 W EP2018086750 W EP 2018086750W WO 2019122407 A3 WO2019122407 A3 WO 2019122407A3
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WO
WIPO (PCT)
Prior art keywords
blood
treatment
extracorporeal
carbon dioxide
dioxide content
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Application number
PCT/EP2018/086750
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English (en)
French (fr)
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WO2019122407A2 (de
Inventor
Petra Abel
Jürgen KLEWINGHAUS
Rolf Zander
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Fresenius Medical Care Deutschland Gmbh
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Publication date
Application filed by Fresenius Medical Care Deutschland Gmbh filed Critical Fresenius Medical Care Deutschland Gmbh
Priority to EP18833664.8A priority Critical patent/EP3727493A2/de
Priority to US16/954,217 priority patent/US11904083B2/en
Priority to CN201880089400.0A priority patent/CN111712273A/zh
Publication of WO2019122407A2 publication Critical patent/WO2019122407A2/de
Publication of WO2019122407A3 publication Critical patent/WO2019122407A3/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1698—Blood oxygenators with or without heat-exchangers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621—Constructional aspects thereof
    • A61M1/1629—Constructional aspects thereof with integral heat exchanger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1694—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid
    • A61M1/1696—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid with dialysate regeneration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3455—Substitution fluids
    • A61M1/3462—Circuits for the preparation thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3496—Plasmapheresis; Leucopheresis; Lymphopheresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0225—Carbon oxides, e.g. Carbon dioxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • External Artificial Organs (AREA)

Abstract

Die vorliegende Erfindung betrifft verschiedene Aspekte einer Vorgehensweise zur Reduzierung des Kohlendioxidgehaltes im Blut bei der Behandlung von Patienten. Ein erster Aspekt der vorliegenden Erfindung betrifft eine Pufferlösung zur Verwendung in der Reduzierung des Kohlendioxidgehaltes im Blut bei der Behandlung eines Patienten, der unter Lungeninsuffizienz oder dem vollständigen Ausfall der Lungenfunktion leidet, wobei die Flüssigkeit mit einem Anteil des Blutes des Patienten, der über einen extrakorporalen Kreislauf geführt wird, im Gasaustausch steht. Der erste Aspekt der Erfindung betrifft weiterhin eine Vorrichtung zur extrakorporalen Reduzierung des Kohlendioxidgehalts im Blut unter Verwendung der genannten Pufferlösung. Ein zweiter Aspekt der Erfindung betrifft ein System zur extrakorporalen Blutbehandlung, ebenfalls unter Verwendung der genannten Pufferlösung und der Vorrichtung, weiterhin eine Behandlungsvorrichtung zur extrakorporalen Blutbehandlung umfassend das vorgenannte System. Ein dritter Aspekt der Erfindung betrifft eine Funktionseinheit zur Durchführung einer extrakorporalen Blutbehandlung, eine Blutführungsvorrichtung zum Zusammenwirken mit der Funktionseinheit zur Durchführung einer extrakorporalen Blutbehandlung unter Verwendung der vorgenannten Pufferlösung, aufweisend ein Blutbehandlungselement, wobei das Blutbehandlungselement die vorgenannte Vorrichtung zur extrakorporalen Reduzierung des Kohlendioxidgehaltes im Blut ist. In einem vierten Aspekt betrifft die Erfindung ein Behandlungssystem umfassend die vorgenannte Vorrichtung zur extrakorporalen Reduzierung des Kohlendioxidgehalts im Blut sowie eine Bilanzierungseinrichtung. In einem fünften Aspekt betrifft die Erfindung ein Behandlungssystem umfassend die vorgenannte Vorrichtung zur extrakorporalen Reduzierung des Kohlendioxidgehalts im Blut sowie ein Mittel zur Minderung des Drucks der verwendeten vorgenannten Pufferlösung in dem genannten Behandlungssystem.
PCT/EP2018/086750 2017-12-22 2018-12-21 Behandlungsaspekte zur reduzierung des kohlendioxidgehalts im blut WO2019122407A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP18833664.8A EP3727493A2 (de) 2017-12-22 2018-12-21 Behandlungsaspekte zur reduzierung des kohlendioxidgehalts im blut
US16/954,217 US11904083B2 (en) 2017-12-22 2018-12-21 Treatment aspects for reducing the carbon dioxide content in the blood
CN201880089400.0A CN111712273A (zh) 2017-12-22 2018-12-21 用于降低血液中二氧化碳含量的治疗方面

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102017131192.0A DE102017131192A1 (de) 2017-12-22 2017-12-22 Pufferlösung zur Reduzierung des Kohlendioxidgehaltes in extrakorporalem Blut
DE102017131192.0 2017-12-22

Publications (2)

Publication Number Publication Date
WO2019122407A2 WO2019122407A2 (de) 2019-06-27
WO2019122407A3 true WO2019122407A3 (de) 2019-08-15

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PCT/EP2018/086750 WO2019122407A2 (de) 2017-12-22 2018-12-21 Behandlungsaspekte zur reduzierung des kohlendioxidgehalts im blut

Country Status (5)

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US (1) US11904083B2 (de)
EP (1) EP3727493A2 (de)
CN (1) CN111712273A (de)
DE (1) DE102017131192A1 (de)
WO (1) WO2019122407A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113975981B (zh) * 2021-09-07 2022-09-27 南京工业大学 一种聚4-甲基-1-戊烯/聚砜共混中空纤维膜、制备方法及在人工肺中的应用

Citations (4)

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DE3321200C2 (de) * 1983-06-11 1991-10-02 Rolf Prof. Dr.Med. 6500 Mainz De Zander
DE19622184A1 (de) * 1996-06-03 1997-12-04 Joern Martens Tragbares Gerät zur Langzeit-Perfusion von menschlichen und tierischen Geweben, als Herz-Lungen-Nieren-Leber-Maschine, für die umfassende, funktionell stützende Behandlung und besonders auch für die lebenserhaltende Notfall-Perfusion, zur Notfall-Versorgung von Patienten
WO2014113740A1 (en) * 2013-01-18 2014-07-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Removal of carbon dioxide via dialysis
WO2017085291A1 (en) * 2015-11-20 2017-05-26 Hepa Wash Gmbh Method for extracorporeal carbon dioxide removal

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US4770774A (en) 1985-09-19 1988-09-13 Toray Industries, Inc. Column for removing β2 -microglobulin
GB2200745A (en) 1987-02-03 1988-08-10 Kc Products Limited Multi-function crop conditioner
AU5286590A (en) 1989-03-31 1990-11-05 Baxter International Inc. Multiple blood path membrane oxygenator
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DE10355042B3 (de) * 2003-11-25 2005-06-23 Fresenius Medical Care Deutschland Gmbh Verfahren und Vorrichtung zum Erkennen von Störungen des Blutflusses in einem extrakorporalen Blutkreislauf
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DE102010024650A1 (de) 2010-05-04 2011-11-10 Medos Medizintechnik Ag Blutpumpe mit einem Rotor
DE102010023635A1 (de) * 2010-06-14 2011-12-15 Fresenius Medical Care Deutschland Gmbh Vorrichtung und Verfahren zum Fördern von Flüssigkeiten in die Behandlungseinheit einer medizinischen Behandlungsvorrichtung, insbesondere in den Dialysator einer Dialysevorrichtung
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Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3321200C2 (de) * 1983-06-11 1991-10-02 Rolf Prof. Dr.Med. 6500 Mainz De Zander
DE19622184A1 (de) * 1996-06-03 1997-12-04 Joern Martens Tragbares Gerät zur Langzeit-Perfusion von menschlichen und tierischen Geweben, als Herz-Lungen-Nieren-Leber-Maschine, für die umfassende, funktionell stützende Behandlung und besonders auch für die lebenserhaltende Notfall-Perfusion, zur Notfall-Versorgung von Patienten
WO2014113740A1 (en) * 2013-01-18 2014-07-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Removal of carbon dioxide via dialysis
WO2017085291A1 (en) * 2015-11-20 2017-05-26 Hepa Wash Gmbh Method for extracorporeal carbon dioxide removal

Also Published As

Publication number Publication date
US20200338253A1 (en) 2020-10-29
CN111712273A (zh) 2020-09-25
EP3727493A2 (de) 2020-10-28
WO2019122407A2 (de) 2019-06-27
DE102017131192A1 (de) 2019-06-27
US11904083B2 (en) 2024-02-20

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