WO2019114046A1

WO2019114046A1 - Ultrasonic device and animal fixation device

Info

Publication number: WO2019114046A1
Application number: PCT/CN2017/120103
Authority: WO
Inventors: 郑海荣; 郭瑞彪; 李永川; 唐彩云; 黄继卿
Original assignee: 深圳先进技术研究院
Priority date: 2017-12-13
Filing date: 2017-12-29
Publication date: 2019-06-20
Also published as: CN109907856A

Abstract

An ultrasonic device and an animal fixation device. The ultrasonic device comprises: a base (1), an ultrasonic probe (2), and an adjusting component (3) connecting the base (1) and the ultrasonic probe (2). The adjusting component (3) drives the ultrasonic probe (2) to adjust in any direction. The animal fixation device comprises: a tooth hook (6), a fixation mechanism (7), and the ultrasonic device. The fixation mechanism (7) is provided on the base (1) and is for fixing four limbs of an animal under experiment. One end of the tooth hook (6) is hingedly connected to the base (1) of the ultrasonic device, and the other end is provided with a slot (61) for tightly holding a tooth of the animal under experiment. The adjusting component (3) is configured to perform the adjustment of the ultrasonic probe (2) any direction. Before a ligature is released and the animal under experiment is re-perfused, the ultrasonic probe (2) having configured ultrasonic parameters is moved to a lesion of the animal under experiment in advance such that when reperfusion occurs, ultrasonic controllable site-specific stimulation treatment is carried out, thereby improving the experimental accuracy and treatment efficacy.

Description

Ultrasound device and animal fixture

Cross-reference to related applications

The present application claims priority to Chinese Patent Application Serial No. JP-A No. No. No. No. No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No

Technical field

The invention relates to the technical field of experimental equipment, in particular to an ultrasonic device and an animal fixing device.

Background technique

Ischemic heart disease is the leading cause of heart failure and has become a major disease that seriously endangers human health. At present, the main clinical use of arterial bypass, thrombolysis, percutaneous transluminal coronary angioplasty, cardiac surgery cardiopulmonary bypass or cardiopulmonary cerebral resuscitation, so that the ischemic heart regains blood perfusion and oxygen supply in a short time; however, myocardial The process of ischemic recovery and blood perfusion often causes myocardial dysfunction and irreversible damage, leading to the deterioration of the patient's condition and even death. Therefore, the research on ischemic heart disease has received extensive attention.

At present, the research on ischemic heart disease mainly focuses on animal experiments. In order to imitate human heart ischemia, the animal's heart is ligated during the experiment, and then the ligature is released, the blood is poured into the animal heart, and the ligature is unwound. At the instant of reperfusion, the ultrasonic device is used to control the fixed point to break the microbubbles, thereby releasing high concentration of hydrogen or drugs for treatment in the lesion site. In the existing experiments, the ultrasound device is generally controlled to align the ultrasound probe to the animal lesion after the completion of the blood perfusion, and the treatment time is delayed by a period of time compared with the blood perfusion time, thus affecting the actual treatment and experimental results.

That is, in the actual operation of the existing ultrasonic device, the time for controlling the ultrasonic probe to treat the lesion site is delayed compared to the time for the cardiac ligation animal to unrect the ligature reperfusion, thus affecting the actual treatment and experimental results.

Summary of the invention

The object of the present invention is to provide an ultrasonic device and an animal fixing device to solve the problem that the ultrasonic device existing in the prior art can control the time of treatment of the lesion portion of the ultrasonic probe in comparison with the ligature of the heart ligation animal. There is a delay in the time of perfusion, which affects the technical problems of actual treatment and experimental results.

The ultrasonic device provided by the present invention comprises a base, an adjusting component and an ultrasonic probe, one end of the adjusting component is connected to the base, and the ultrasonic probe is detachably fixed to the other end of the adjusting component, the base The method is used for fixing an experimental animal, and the adjusting component is configured to drive the ultrasonic probe to perform position adjustment.

Further, the adjusting component comprises a flexible adjusting rod, the two ends of the flexible adjusting rod are respectively a fixed end and an adjusting end, and the fixed end is detachably fixed on the base, and the ultrasonic probe is detachable It is fixed to the adjustment end of the flexible adjustment rod.

Further, the adjusting end of the flexible adjusting rod is detachably fixed with a probe clip, the probe clip includes an open collar, and the shape of the collar matches the shape of the ultrasonic probe; the collar A connecting ear is fixedly disposed, and the connecting ear is detachably fixed to the adjusting end of the flexible adjusting rod, and both end ends of the opening of the collar are fixed with a fastening ear along a radial direction thereof The collar is provided with a locking member, and the locking member realizes locking or loosening of the ultrasonic probe in the collar by controlling the distance between the two fastening ears;

Preferably, the locking member comprises a third threaded fastener and a nut, and the two fastening ears are provided with corresponding through holes, and the third threaded fastener passes through the two through holes in sequence. a hole, the nut being screwed to an end of the third threaded fastener passing through the through hole.

Further, a collimator is further provided, the outer wall of the ultrasonic probe is provided with an external thread, and an inner wall of the collimator is provided with an internal thread, and the internal thread is matched with the external thread.

Another object of the present invention is to provide an animal fixing device comprising a tooth hook, a fixing mechanism and the above ultrasonic device, the fixing mechanism being provided on the base and for fixing the limbs of the experimental animal, the teeth One end of the hook is hinged to the base of the ultrasonic device, and the other end is provided with a card slot for clamping the teeth of the experimental animal. The animal fixing device has all the technical effects of the above ultrasonic device.

Further, the base is provided with a “T”-shaped slot, and one end of the tooth hook hinged to the base is provided with a sleeve, and the sleeve is internally provided with a rotating shaft, and the rotating shaft is engaged with the “T” a "-" groove in the slot and capable of sliding within the "-" slot, the tooth hook extending through the "|" slot of the "T" shaped slot out of the upper surface of the base;

Preferably, one end of the "T" shaped groove is in communication with the outside.

Further, both ends of the rotating shaft are connected with rectangular blocks, and the two rectangular blocks are all snapped into the "-" groove and can slide in the "-" groove.

Further, the base is provided with a first pressing member, and the first pressing member is used for pressing or loosening the rectangular block in the "-" slot;

Preferably, the first pressing member comprises a first threaded fastener, and the base has two rows of first threaded holes along the length direction of the "T" shaped groove, and each of the first threaded holes Passing through the "-" groove, the first threaded fastener is threaded into the first threaded hole and presses the corresponding rectangular block.

Further, the fixing mechanism includes a pressing plate and a second pressing member, the pressing plate includes an outwardly convex curved plate and a connecting plate fixed to both ends of the curved plate, and the second pressing member is used Pressing the connecting plate on the base;

Preferably, the second pressing member comprises a second threaded fastener, the connecting plate is provided with a through hole, the base is provided with a second threaded hole, and the second threaded fastener passes through the The through hole is screwed to the second threaded hole; the pressure plate is five, the second threaded hole is corresponding to five groups, and the five sets of the second threaded hole respectively correspond to the limbs and tail of the experimental animal The location corresponds.

Further, each of the second threaded holes includes a plurality of rows of second threaded holes, and the rows of the second threaded holes are arranged along the length of the limbs or tails of the laboratory animal.

The beneficial effects of the ultrasonic device and the animal fixing device of the present invention are:

The invention provides an ultrasonic device and an animal fixing device, wherein the ultrasonic device comprises an ultrasonic probe for ultrasonic stimulation treatment of an experimental animal fixed on the base as a base for a surgical operation platform (the ultrasonic probe and the device are used when used) And an adjustment member for carrying the ultrasonic probe and capable of adjusting the ultrasonic probe to each of the positions; wherein the animal fixture includes a fixing mechanism for fixing the experimental animal to the base, and a dental hook for fixing the teeth of the experimental animal And the above-described ultrasonic device capable of ultrasonically stimulating treatment of an experimental animal fixed to the base.

In the experiment, the ultrasonic probe is first adjusted to a position that does not hinder the surgical operation by controlling the adjusting member, and then the experimental animal is fixed on the base, wherein the fixing mechanism is used for fixing the limbs of the experimental animal, and the dental hook is used to fix the teeth of the experimental animal. The fixation of the teeth of the experimental animals is completed in the card slot; after the experimental animals are fixed, the experimental animals are subjected to cardiac ligation or other operations. After the operation is completed, the ligatures are ready to be released and the blood flow is reperfused to the experimental animals. The device connected with the ultrasonic probe adjusts a series of ultrasonic stimulation parameters of the ultrasonic probe, and controls the adjusting component to adjust the ultrasonic probe to the lesion site of the experimental animal, and the ultrasound probe can be opened at the moment of reperfusion of the blood flow to realize reperfusion. Ultrasound controllable fixed-point stimulation therapy can be achieved in an instant, thereby improving the accuracy of the experiment and the therapeutic effect.

That is, the setting of the flexible adjusting rod can realize the adjustment of the various positions of the ultrasonic probe. Before the re-infusion of the ligature and the re-infusion of the experimental animal, the ultrasonic probe with the ultrasonic parameters can be adjusted to the lesion part of the experimental animal in advance, thereby realizing Ultrasound controllable fixed-point stimulation treatment is performed at the moment of perfusion, which improves the accuracy of the experiment and the therapeutic effect.

DRAWINGS

In order to more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the drawings to be used in the specific embodiments or the description of the prior art will be briefly described below, and obviously, the attached in the following description The drawings are some embodiments of the present invention, and those skilled in the art can obtain other drawings based on these drawings without any creative work.

1 is a schematic diagram of a three-dimensional structure of an animal fixing device according to an embodiment of the present invention;

2 is a schematic diagram of a three-dimensional explosion structure of an animal fixing device according to an embodiment of the present invention;

3 is a schematic diagram of a three-dimensional structure of an ultrasonic device according to an embodiment of the present invention;

4 is a schematic view showing the three-dimensional structure of the probe clip of FIG. 3;

Figure 5 is a schematic view showing the three-dimensional structure of the tooth hook of Figure 1;

Figure 6 is a three-dimensional structural view of the pressure plate of Figure 1.

Icons: 1-base; 2-ultrasonic probe; 3-flexible adjustment lever; 4-probe clamp; 5-collimator; 6-tooth hook; 7-fixing mechanism; 11-"T" slot; Threaded hole; 13-first threaded fastener; 14-second threaded hole; 41-loop; 42-joint ear; 43-fastened ear; 44-third threaded fastener; 61-card slot; - bushing; 63-shaft; 64-rectangular block; 71-platen; 711-arc plate; 712-joint plate; 72-second threaded fastener.

Detailed ways

The technical solutions of the present invention will be clearly and completely described in the following with reference to the accompanying drawings. It is obvious that the described embodiments are a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative efforts are within the scope of the present invention.

In the description of the present invention, it is to be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inside", "outside", etc. The orientation or positional relationship of the indications is based on the orientation or positional relationship shown in the drawings, and is merely for the convenience of the description of the invention and the simplified description, rather than indicating or implying that the device or component referred to has a specific orientation, in a specific orientation. The construction and operation are therefore not to be construed as limiting the invention. Moreover, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the present invention, it should be noted that the terms "installation", "connected", and "connected" are to be understood broadly, and may be fixed or detachable, for example, unless otherwise explicitly defined and defined. Connected, or integrally connected; can be mechanical or electrical; can be directly connected, or indirectly connected through an intermediate medium, can be the internal communication of the two components. The specific meaning of the above terms in the present invention can be understood in a specific case by those skilled in the art.

The embodiment provides an ultrasonic device, as shown in FIG. 1 to FIG. 3, comprising a base 1, an adjusting component and an ultrasonic probe 2, one end of the adjusting component is connected to the base 1, and the ultrasonic probe 2 is detachably fixed to the adjusting component. At the other end, the base 1 is used to fix the experimental animal, and the adjusting component is used to drive the ultrasonic probe 2 for various positions.

The embodiment further provides an animal fixing device, as shown in FIG. 1 to FIG. 3, comprising a tooth hook 6, a fixing mechanism 7 and the above ultrasonic device. The fixing mechanism 7 is disposed on the base 1 and is used for fixing the limbs of the experimental animal. One end of the dental hook 6 is hinged to the base 1 of the ultrasonic device, and the other end is provided with a card slot 61 for clamping the teeth of the experimental animal.

The ultrasonic device and the animal fixing device provided by the embodiment, wherein the ultrasonic device comprises a base 1 for use as a surgical operation platform, and an ultrasonic probe 2 for ultrasonic stimulation treatment of an experimental animal fixed on the base 1 (when used The ultrasonic probe 2 is connected to the device) and the regulating member for carrying the ultrasonic probe 2 and capable of adjusting the ultrasonic probe 2 to each position; wherein the animal fixing device comprises a fixing mechanism 7 for fixing the experimental animal to the base 1, A dental hook 6 for fixing the teeth of an experimental animal and the above-described ultrasonic device capable of ultrasonically stimulating treatment of an experimental animal fixed to the base 1 can be adjusted in various places.

In the experiment, the ultrasonic probe 2 is first adjusted to a position that does not hinder the surgical operation by controlling the adjustment member, and then the experimental animal is fixed on the base 1, wherein the fixing mechanism 7 is used to fix the limbs of the experimental animal, and the dental hook 6 passes the experiment. The teeth of the animal are inserted into the card slot 61 to complete the fixation of the teeth of the experimental animal; after the experimental animal is fixed, the animal is subjected to a heart ligation operation or other surgery. After the operation is completed, the ligature is prepared to unwind the blood of the experimental animal. During perfusion, a series of ultrasonic stimulation parameters of the ultrasound probe 2 are adjusted by means of a device connected to the ultrasound probe 2, and the adjustment component is adjusted to adjust the ultrasound probe 2 to the lesion site of the experimental animal, and the ultrasound is instantaneously opened for blood flow reperfusion of the animal. With the probe 2, the ultrasonically controllable fixed-point stimulation treatment can be realized at the instant of reperfusion, thereby improving the experimental precision and the therapeutic effect.

That is, the setting of the flexible adjusting rod 3 can realize the adjustment of the various positions of the ultrasonic probe 2, and the ultrasonic probe 2 with the ultrasonic parameters set can be adjusted to the lesion part of the experimental animal in advance before the unclacing line is reperfused for the experimental animal. Therefore, the ultrasound can control the fixed-point stimulation treatment at the instant of reperfusion, and improve the experimental precision and therapeutic effect.

Specifically, the adjusting component may be a flexible rod, and the ultrasonic probe 2 is adjusted by 360° by bending the flexible rod; or the vertical telescopic rod pivotally connected to the base 1 , and the vertical telescopic rod is slidably adjusted to have horizontal expansion and contraction The rod, the horizontal telescopic rod can be adjusted up and down along the length direction of the vertical telescopic rod, the ultrasonic probe 2 is connected to the free end end of the horizontal telescopic rod, and the vertical telescopic rod is rotated circumferentially along the base 1 and the length of the vertical telescopic rod is vertical. The height adjustment of the telescopic and horizontal telescopic rods on the vertical telescopic rod and the length expansion of the horizontal telescopic rods enable 360° adjustment of the ultrasonic probe 2; or other components that can achieve multi-directional adjustment; the fixing mechanism 7 can The method of fixing the rope and fixing the buckle is adopted; the ultrasonic probe 2 can perform the B-ultrasound imaging or the ultrasonic focusing stimulation on the lesion part of the experimental animal.

The fixed end of the flexible adjusting rod 3 can be connected to the base 1 by plugging, or can be screwed to the base 1. Specifically, a screw hole can be arranged on the base 1 at the fixed end of the flexible adjusting rod 3. A screw is provided which matches the threaded hole.

Specifically, in this embodiment, as shown in FIG. 1 to FIG. 3, the adjusting component may include a flexible adjusting rod 3, and the two ends of the flexible adjusting rod 3 are respectively a fixed end and an adjusting end, and the fixed end is detachably fixed on the base. In the first embodiment, the ultrasonic probe 2 is detachably fixed to the adjustment end of the flexible adjustment rod 3. The flexible adjusting rod 3 has a certain hardness, can ensure the support and bearing of the ultrasonic probe 2, and has deformability. The operator can apply the force to the flexible adjusting rod 3, bend the flexible adjusting rod 3, etc. The probe 2 is adjusted in various positions, and the flexible adjustment rod 3 has a simple structure and convenient operation.

In this embodiment, as shown in FIG. 1 to FIG. 4, the adjustment end of the flexible adjustment rod 3 is detachably fixed with a probe holder 4, and the probe holder 4 includes an open collar 41, and the shape of the collar 41 and the ultrasonic probe 2 The shape is matched; the collar 41 is fixed with a connecting ear 42, and the connecting ear 42 is detachably fixed with the adjusting end of the flexible adjusting rod 3, and both end ends of the opening of the collar 41 are radially outward The fastening ear 43 is fixed, and the collar 41 is provided with a locking member, and the locking member realizes the locking or loosening of the ultrasonic probe 2 in the collar 41 by controlling the distance between the two fastening ears 43; The clamping member includes a third threaded fastener 44 and a nut. The two fastening ears 43 are provided with corresponding through holes. The third threaded fastener 44 passes through the two through holes in sequence, and the nut is screwed to the third thread. The fastener 44 passes through one end of the through hole.

Here is a way to detachably connect the ultrasonic probe 2 to the flexible adjustment rod 3, firstly connecting the connecting ear 42 of the probe holder 4 to the adjustment end of the flexible adjustment rod 3, specifically, the flexible adjustment rod The adjusting end of the 3 is fixed with a screw, and the connecting ear 42 of the probe holder 4 is provided with a threaded hole matched with the screw, and the connecting ear 42 is screwed onto the screw through the threaded hole; initially, the locking member is incorrect. The fastening ear 43 is locked, and the collar 41 is provided with an opening. The size of the inner ring of the collar 41 can be adjusted to a certain extent, the ultrasonic probe 2 is inserted into the collar 41, and then the locking member is adjusted to lock and tighten the two fastening ears. The distance between the 43 is reduced, the inner ring of the collar 41 is reduced, and the ultrasonic probe 2 is locked and fixed in the collar 41. Specifically, the third threaded fastener 44 and the nut can be used for the locking member to fasten the third thread. The member 44 passes through the through holes in the two fastening ears 43 at the opening of the collar 41 in turn, and screwes the nut on the third threaded fastener 44 until the two fastening ears 43 are locked to complete the collar 41. Fixed locking of the ultrasonic probe 2.

When the ultrasonic probe 2 needs to be disassembled, simply unscrew or loosen the nut and pull the ultrasonic probe 2 out of the collar 41. The probe clip 4 is detachably mounted on the flexible adjusting rod 3, and the corresponding probe clip 4 can be selected for different types of ultrasonic probes 2, and the inner ring size of the probe clip 4 collar 41 can be adjusted within a certain range, and can also be applied to different The ultrasonic probe 2 of the model has improved convenience.

In this embodiment, as shown in FIG. 1 to FIG. 3, the ultrasonic device may further include a collimator 5, the outer wall of the ultrasonic probe 2 is provided with external threads, and the inner wall of the collimator 5 is provided with internal threads. The internal thread matches the external thread. The ultrasonic wave emitted by the ultrasonic probe 2 is reflected and diffused in various directions, and the collimator 5 can refract the reflected ultrasonic waves in a certain range into parallel waves and transmit them to the optical fiber, thereby being transmitted to the ultrasonic device, so that the ultrasonic device can receive the maximum. The efficiency of the acoustic signal improves the accuracy of the ultrasonic treatment; in addition, the collimator 5 is filled with the coupling fluid of the ultrasonic transmission, and the collimator 5 is screwed to the ultrasonic probe 2, and the collimator 5 can be changed by the thread adjustment. The distance between the ultrasonic probes 2, thereby adjusting the depth of the stimulation of the ultrasonic probe 2, achieves focus stimulation treatment on different depth parts of the experimental animal, no need to replace the different ultrasonic probes 2, the operation is convenient, and the utility of the ultrasonic device is improved.

In this embodiment, as shown in FIG. 1 to FIG. 3, a "T"-shaped groove 11 may be disposed on the base 1. The end of the tooth hook 6 and the base 1 is provided with a sleeve 62, and the sleeve 62 is disposed inside. The rotating shaft 63, the rotating shaft 63 is snapped into the "-" groove of the "T" shaped groove 11, and is slidable in the "-" groove, and the tooth hook 6 protrudes through the "|" groove of the "T" shaped groove 11. The upper surface of the base 1; preferably, one end of the "T" shaped groove 11 communicates with the outside. In use, the rotating shaft 63 is first passed through the sleeve 62 of the tooth hook 6, and the tooth hook 6 can be rotated about the rotating shaft 63, and then the rotating shaft 63 is inserted into the "-" groove of the "T" shaped groove 11, and the rotating shaft 63 is extended at both ends. The position of the output sleeve 62 is caught in the "-" groove, and can be slid along the length of the "T" groove 11 in the "-" groove, and the tooth hook 6 passes through the "|" groove of the "T" groove 11. The upper surface of the base 1 fixes the teeth of the experimental animal. When the shaft 63 slides along the "T" shaped groove 11, the tooth hook 6 can be carried to move, so that the card slot 61 on the tooth hook 6 can be different from different experimental animals. The teeth are matched and the teeth are fixed to different animals, thereby improving the utility of the animal fixture; preferably, one end of the "T" shaped groove 11 communicates with the outside, and when the tooth hook 6 is mounted, it is only required to be mounted on the tooth hook 6 The shaft 63 in the sleeve 62 can be inserted from the end of the "T"-shaped groove 11 that communicates with the outside, and is easy to install.

Specifically, the card slot 61 on the tooth hook 6 may be an elongated card slot 61. The length direction of the card slot 61 is perpendicular to the direction of movement of the tooth hook 6 along the "-" slot, so that the teeth of the experimental animal are in the card slot 61. A large range in the longitudinal direction can be caught in the card slot 61, improving the utility of the tooth hook 6.

In this embodiment, as shown in FIG. 2 and FIG. 5, a rectangular block 64 may be connected to both ends of the rotating shaft 63, and both rectangular blocks 64 are locked into the "-" slot, and can be in the " - "sliding in the groove; the base 1 is provided with a first pressing member for pressing or loosening the rectangular block 64 in the "-" groove; preferably, the first pressing member comprises the first thread The fastener 13 has two rows of first threaded holes 12 along the length of the "T" shaped groove 11 on the base 1. Each of the first threaded holes 12 is penetrated by a "-" groove, and the first threaded fastener 13 is threaded. Fitted into the first threaded bore 12 and pressed against the corresponding rectangular block 64. The rectangular block 64 is more closely matched with the end of the cylindrical rotating shaft 63 in the "-" groove to improve the connection stability of the rotating shaft 63 and the base 1. Initially, the first pressing member is not locked with the rectangular block. 64, the rectangular block 64 can be adjusted along the length direction of the "-" slot. After the adjustment is completed, the first pressing member is locked to lock the rectangular block 64, and the positions of the rectangular block 64 and the rotating shaft 63 are fixed on the base 1 to reduce the teeth. After the hook 6 catches the teeth of the experimental animal, under the struggle of the experimental animal, the rectangular block 64 and the rotating shaft 63 slide along the "T" shaped groove 11, which causes the loosening of the teeth of the experimental animal from the card slot 61, thereby improving The fixing of the tooth hook 6 is firm.

Specifically, the first pressing member may select the first threaded fastener 13 to relax and compress the rectangular block 64 by adjusting the depth of the first threaded fastener 13 into the first threaded hole 12. At the same time, the first threaded holes 12 are arranged in two rows and arranged along the length direction of the "T" shaped groove, and the operator can select the corresponding first threaded hole 12 according to the position of the rectangular block 64 after the adjustment is completed, and secondly, two The first threaded fasteners 13 simultaneously press and fix the two rectangular blocks 64 at both ends of the rotating shaft 63, further improving the fixing stability of the tooth hooks 6.

In this embodiment, as shown in FIG. 1 , FIG. 2 and FIG. 6 , the fixing mechanism 7 may include a pressing plate 71 and a second pressing member, and the pressing plate 71 includes an outwardly convex curved plate 711 and is fixed on the curved plate. a connecting plate 712 at both ends of the 711, the second pressing member is used for pressing the connecting plate 712 against the base 1; preferably, the second pressing member comprises a second threaded fastener 72, and the connecting plate 712 is provided with a through hole The second threaded hole 14 is disposed on the base 1 , and the second threaded fastener 72 is threadedly connected to the second threaded hole 14 through the through hole; the pressure plate 71 is five, and the second threaded hole 14 is corresponding to five groups, and five The second threaded holes 14 of the set correspond to the limbs and tail positions of the experimental animals, respectively. Initially, the pressing plate 71 is not pressed by the second pressing member, and when the experimental animal is fixed by the fixing mechanism 7, the limbs or tails of the experimental animal are extended into the curved space formed by the curved plate 711 of the pressing plate 71, and then Adjusting the second pressing member presses the connecting plate 712 against the base 1 to complete the fixing of the limbs and the tail of the experimental animal.

Specifically, the second pressing member may be a second threaded fastener 72, and the second threaded fastener 72 is passed through the through hole of the pressing plate 71 connecting plate 712 and aligned with the corresponding second thread on the base 1. The hole 14 is screwed therein, and the two connecting plates 712 at both ends of the pressing plate 71 are respectively provided with a second threaded fastener 72, and the second threaded fastener 72 presses the two ends of the pressing plate 71 to improve the pressing plate 71. The tightness of the compaction ensures that the pressure plate 71 is fixed to the experimental animals. Specifically, the pressure plate 71 is divided into five groups, and the limbs and tails of the experimental animals are respectively fixed.

In this embodiment, as shown in FIG. 3, each set of second threaded holes 14 includes a plurality of rows of second threaded holes 14, each of which is arranged along the length of the limbs or tail of the laboratory animal. Each set of second threaded holes 14 includes a plurality of rows of second threaded holes 14, each row being provided with two second threaded holes 14 respectively corresponding to the through holes in the platen 712 of the pressure plate 71, and the plurality of rows of second threaded holes 14 are along The limbs or tails of the experimental animals are arranged in the longitudinal direction to accommodate the different sizes of the experimental animals, and the limbs and tails are fixed on the base 1 to fix the experimental animals, thereby further improving the utility of the animal fixture.

It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and are not limited thereto; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that The technical solutions described in the foregoing embodiments are modified, or some or all of the technical features are equivalently substituted; and the modifications or substitutions do not deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

An ultrasonic device comprising a base (1), an adjustment member and an ultrasonic probe (2), one end of the adjustment member being coupled to the base (1), the ultrasonic probe (2) being detachable Fixed at the other end of the adjusting member, the base (1) is configured to fix an experimental animal, and the adjusting member is configured to drive the ultrasonic probe (2) to perform position adjustment.
The ultrasonic device according to claim 1, wherein the adjusting member comprises a flexible adjusting rod (3), and two ends of the flexible adjusting rod (3) are respectively a fixed end and an adjusting end, and the fixed end is The detachable type is fixed on the base (1), and the ultrasonic probe (2) is detachably fixed to the adjusting end of the flexible adjusting rod (3).
The ultrasonic device according to claim 2, characterized in that the adjustment end of the flexible adjustment rod (3) is detachably fixed with a probe holder (4), and the probe holder (4) comprises an open collar ( 41), the shape of the collar (41) matches the shape of the ultrasonic probe (2); the collar (41) is fixed with a connecting ear (42), and the connecting ear (42) is The adjusting end of the flexible adjusting rod (3) is detachably fixed, and both end ends of the opening of the collar (41) are fixed with a fastening ear (43) along a radial direction thereof. The collar (41) is provided with a locking member, which realizes the ultrasonic probe (2) in the collar (41) by controlling the distance between the two fastening ears (43) Lock or relax;

Preferably, the locking member comprises a third threaded fastener (44) and a nut, and the two fastening ears (43) are provided with corresponding through holes, and the third threaded fastener (44) Passing through the two through holes in sequence, the nut is screwed to one end of the third threaded fastener (44) through the through hole.
The ultrasonic device according to any one of claims 1 to 3, further comprising a collimator (5), the outer wall of the ultrasonic probe (2) is provided with an external thread, the collimator ( The inner wall of 5) is provided with an internal thread that matches the external thread.
An animal fixing device, comprising: a dental hook (6), a fixing mechanism (7), and the ultrasonic device according to any one of claims 1 to 4, wherein the fixing mechanism (7) is provided on the base (1) upper, and configured to fix the limbs of the experimental animal, one end of the dental hook (6) is hinged to the base (1) of the ultrasonic device, and the other end is provided with a card slot (61), The card slot (61) is configured to grip the teeth of the laboratory animal.
The animal fixing device according to claim 5, wherein the base (1) is provided with a "T" shaped groove (11), and the end of the tooth hook (6) hinged with the base (1) a sleeve (62) is disposed, the sleeve (62) is internally provided with a rotating shaft (63), and the rotating shaft (63) is inserted into the "-" groove of the "T" shaped groove (11), and Being slidable within the "-" groove, the tooth hook (6) extending through the "|" groove of the "T" shaped groove (11) out of the upper surface of the base (1);

Preferably, one end of the "T" shaped groove (11) is in communication with the outside.
The animal fixing device according to claim 6, wherein both ends of the rotating shaft (63) are connected with a rectangular block (64), and both of the rectangular blocks (64) are snapped into the "-" "Slot and can slide within the "-" slot.
The animal fixing device according to claim 7, wherein the base (1) is provided with a first pressing member, and the first pressing member is configured to press or loosen the "-" groove. The rectangular block (64);

Preferably, the first pressing member comprises a first threaded fastener (13), and the base (1) is provided with two rows of first threaded holes along the length direction of the "T" shaped groove (11). (12), each of the first threaded holes (12) is penetrated with the "-" groove, and the first threaded fastener (13) is threaded into the first threaded hole (12) and pressed accordingly The rectangular block (64).
The animal fixing device according to any one of claims 5-8, characterized in that the fixing mechanism (7) comprises a pressing plate (71) and a second pressing member, the pressing plate (71) comprising an outward convex a curved plate (711) and a connecting plate (712) fixed at both ends of the curved plate (711), the second pressing member being configured to press the connecting plate (712) against the On the base (1);

Preferably, the second pressing member comprises a second threaded fastener (72), the connecting plate (712) is provided with a through hole, and the base (1) is provided with a second threaded hole (14) The second threaded fastener (72) is threadedly coupled to the second threaded hole (14) through the through hole;

The press plates (71) are five, the second threaded holes (14) are correspondingly five sets, and the five sets of the second threaded holes (14) respectively correspond to the limbs and tail positions of the experimental animals.
The animal fastening device according to claim 9, wherein each of said second threaded holes (14) comprises a plurality of rows of second threaded holes (14), and said plurality of said second threaded holes (14) The length of the limbs or tail of the experimental animal is arranged.