WO2019114046A1 - Dispositif ultrasonore et dispositif de fixation d'animal - Google Patents

Dispositif ultrasonore et dispositif de fixation d'animal Download PDF

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Publication number
WO2019114046A1
WO2019114046A1 PCT/CN2017/120103 CN2017120103W WO2019114046A1 WO 2019114046 A1 WO2019114046 A1 WO 2019114046A1 CN 2017120103 W CN2017120103 W CN 2017120103W WO 2019114046 A1 WO2019114046 A1 WO 2019114046A1
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WO
WIPO (PCT)
Prior art keywords
base
ultrasonic
animal
ultrasonic probe
threaded
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PCT/CN2017/120103
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English (en)
Chinese (zh)
Inventor
郑海荣
郭瑞彪
李永川
唐彩云
黄继卿
Original Assignee
深圳先进技术研究院
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Application filed by 深圳先进技术研究院 filed Critical 深圳先进技术研究院
Publication of WO2019114046A1 publication Critical patent/WO2019114046A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D3/00—Appliances for supporting or fettering animals for operative purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia

Definitions

  • the invention relates to the technical field of experimental equipment, in particular to an ultrasonic device and an animal fixing device.
  • Ischemic heart disease is the leading cause of heart failure and has become a major disease that seriously endangers human health.
  • the main clinical use of arterial bypass, thrombolysis, percutaneous transluminal coronary angioplasty, cardiac surgery cardiopulmonary bypass or cardiopulmonary cerebral resuscitation so that the ischemic heart regains blood perfusion and oxygen supply in a short time; however, myocardial
  • the process of ischemic recovery and blood perfusion often causes myocardial dysfunction and irreversible damage, leading to the deterioration of the patient's condition and even death. Therefore, the research on ischemic heart disease has received extensive attention.
  • the research on ischemic heart disease mainly focuses on animal experiments.
  • the animal's heart is ligated during the experiment, and then the ligature is released, the blood is poured into the animal heart, and the ligature is unwound.
  • the ultrasonic device is used to control the fixed point to break the microbubbles, thereby releasing high concentration of hydrogen or drugs for treatment in the lesion site.
  • the ultrasound device is generally controlled to align the ultrasound probe to the animal lesion after the completion of the blood perfusion, and the treatment time is delayed by a period of time compared with the blood perfusion time, thus affecting the actual treatment and experimental results.
  • the time for controlling the ultrasonic probe to treat the lesion site is delayed compared to the time for the cardiac ligation animal to unrect the ligature reperfusion, thus affecting the actual treatment and experimental results.
  • the object of the present invention is to provide an ultrasonic device and an animal fixing device to solve the problem that the ultrasonic device existing in the prior art can control the time of treatment of the lesion portion of the ultrasonic probe in comparison with the ligature of the heart ligation animal. There is a delay in the time of perfusion, which affects the technical problems of actual treatment and experimental results.
  • the method is used for fixing an experimental animal, and the adjusting component is configured to drive the ultrasonic probe to perform position adjustment.
  • the adjusting component comprises a flexible adjusting rod, the two ends of the flexible adjusting rod are respectively a fixed end and an adjusting end, and the fixed end is detachably fixed on the base, and the ultrasonic probe is detachable It is fixed to the adjustment end of the flexible adjustment rod.
  • the adjusting end of the flexible adjusting rod is detachably fixed with a probe clip
  • the probe clip includes an open collar
  • the shape of the collar matches the shape of the ultrasonic probe
  • the collar A connecting ear is fixedly disposed, and the connecting ear is detachably fixed to the adjusting end of the flexible adjusting rod, and both end ends of the opening of the collar are fixed with a fastening ear along a radial direction thereof
  • the collar is provided with a locking member, and the locking member realizes locking or loosening of the ultrasonic probe in the collar by controlling the distance between the two fastening ears;
  • the locking member comprises a third threaded fastener and a nut, and the two fastening ears are provided with corresponding through holes, and the third threaded fastener passes through the two through holes in sequence. a hole, the nut being screwed to an end of the third threaded fastener passing through the through hole.
  • a collimator is further provided, the outer wall of the ultrasonic probe is provided with an external thread, and an inner wall of the collimator is provided with an internal thread, and the internal thread is matched with the external thread.
  • Another object of the present invention is to provide an animal fixing device comprising a tooth hook, a fixing mechanism and the above ultrasonic device, the fixing mechanism being provided on the base and for fixing the limbs of the experimental animal, the teeth One end of the hook is hinged to the base of the ultrasonic device, and the other end is provided with a card slot for clamping the teeth of the experimental animal.
  • the animal fixing device has all the technical effects of the above ultrasonic device.
  • the base is provided with a “T”-shaped slot
  • one end of the tooth hook hinged to the base is provided with a sleeve
  • the sleeve is internally provided with a rotating shaft, and the rotating shaft is engaged with the “T” a "-” groove in the slot and capable of sliding within the "-” slot, the tooth hook extending through the "
  • one end of the "T" shaped groove is in communication with the outside.
  • both ends of the rotating shaft are connected with rectangular blocks, and the two rectangular blocks are all snapped into the "-" groove and can slide in the "-" groove.
  • the base is provided with a first pressing member, and the first pressing member is used for pressing or loosening the rectangular block in the "-" slot;
  • the first pressing member comprises a first threaded fastener
  • the base has two rows of first threaded holes along the length direction of the "T" shaped groove, and each of the first threaded holes Passing through the "-" groove, the first threaded fastener is threaded into the first threaded hole and presses the corresponding rectangular block.
  • the fixing mechanism includes a pressing plate and a second pressing member, the pressing plate includes an outwardly convex curved plate and a connecting plate fixed to both ends of the curved plate, and the second pressing member is used Pressing the connecting plate on the base;
  • the second pressing member comprises a second threaded fastener
  • the connecting plate is provided with a through hole
  • the base is provided with a second threaded hole
  • the second threaded fastener passes through the The through hole is screwed to the second threaded hole
  • the pressure plate is five
  • the second threaded hole is corresponding to five groups
  • the five sets of the second threaded hole respectively correspond to the limbs and tail of the experimental animal The location corresponds.
  • each of the second threaded holes includes a plurality of rows of second threaded holes, and the rows of the second threaded holes are arranged along the length of the limbs or tails of the laboratory animal.
  • the invention provides an ultrasonic device and an animal fixing device, wherein the ultrasonic device comprises an ultrasonic probe for ultrasonic stimulation treatment of an experimental animal fixed on the base as a base for a surgical operation platform (the ultrasonic probe and the device are used when used) And an adjustment member for carrying the ultrasonic probe and capable of adjusting the ultrasonic probe to each of the positions; wherein the animal fixture includes a fixing mechanism for fixing the experimental animal to the base, and a dental hook for fixing the teeth of the experimental animal And the above-described ultrasonic device capable of ultrasonically stimulating treatment of an experimental animal fixed to the base.
  • the ultrasonic device comprises an ultrasonic probe for ultrasonic stimulation treatment of an experimental animal fixed on the base as a base for a surgical operation platform (the ultrasonic probe and the device are used when used) And an adjustment member for carrying the ultrasonic probe and capable of adjusting the ultrasonic probe to each of the positions; wherein the animal fixture includes a fixing mechanism for fixing the experimental animal to the base, and a dental hook for fixing
  • the ultrasonic probe is first adjusted to a position that does not hinder the surgical operation by controlling the adjusting member, and then the experimental animal is fixed on the base, wherein the fixing mechanism is used for fixing the limbs of the experimental animal, and the dental hook is used to fix the teeth of the experimental animal.
  • the fixation of the teeth of the experimental animals is completed in the card slot; after the experimental animals are fixed, the experimental animals are subjected to cardiac ligation or other operations. After the operation is completed, the ligatures are ready to be released and the blood flow is reperfused to the experimental animals.
  • the device connected with the ultrasonic probe adjusts a series of ultrasonic stimulation parameters of the ultrasonic probe, and controls the adjusting component to adjust the ultrasonic probe to the lesion site of the experimental animal, and the ultrasound probe can be opened at the moment of reperfusion of the blood flow to realize reperfusion.
  • Ultrasound controllable fixed-point stimulation therapy can be achieved in an instant, thereby improving the accuracy of the experiment and the therapeutic effect.
  • the setting of the flexible adjusting rod can realize the adjustment of the various positions of the ultrasonic probe.
  • the ultrasonic probe with the ultrasonic parameters can be adjusted to the lesion part of the experimental animal in advance, thereby realizing Ultrasound controllable fixed-point stimulation treatment is performed at the moment of perfusion, which improves the accuracy of the experiment and the therapeutic effect.
  • FIG. 1 is a schematic diagram of a three-dimensional structure of an animal fixing device according to an embodiment of the present invention
  • FIG. 2 is a schematic diagram of a three-dimensional explosion structure of an animal fixing device according to an embodiment of the present invention
  • FIG. 3 is a schematic diagram of a three-dimensional structure of an ultrasonic device according to an embodiment of the present invention.
  • FIG. 4 is a schematic view showing the three-dimensional structure of the probe clip of FIG. 3;
  • Figure 5 is a schematic view showing the three-dimensional structure of the tooth hook of Figure 1;
  • Figure 6 is a three-dimensional structural view of the pressure plate of Figure 1.
  • Icons 1-base; 2-ultrasonic probe; 3-flexible adjustment lever; 4-probe clamp; 5-collimator; 6-tooth hook; 7-fixing mechanism; 11-"T" slot; Threaded hole; 13-first threaded fastener; 14-second threaded hole; 41-loop; 42-joint ear; 43-fastened ear; 44-third threaded fastener; 61-card slot; - bushing; 63-shaft; 64-rectangular block; 71-platen; 711-arc plate; 712-joint plate; 72-second threaded fastener.
  • connection In the description of the present invention, it should be noted that the terms “installation”, “connected”, and “connected” are to be understood broadly, and may be fixed or detachable, for example, unless otherwise explicitly defined and defined. Connected, or integrally connected; can be mechanical or electrical; can be directly connected, or indirectly connected through an intermediate medium, can be the internal communication of the two components.
  • Connected, or integrally connected can be mechanical or electrical; can be directly connected, or indirectly connected through an intermediate medium, can be the internal communication of the two components.
  • the specific meaning of the above terms in the present invention can be understood in a specific case by those skilled in the art.
  • the embodiment provides an ultrasonic device, as shown in FIG. 1 to FIG. 3, comprising a base 1, an adjusting component and an ultrasonic probe 2, one end of the adjusting component is connected to the base 1, and the ultrasonic probe 2 is detachably fixed to the adjusting component.
  • the base 1 is used to fix the experimental animal, and the adjusting component is used to drive the ultrasonic probe 2 for various positions.
  • the embodiment further provides an animal fixing device, as shown in FIG. 1 to FIG. 3, comprising a tooth hook 6, a fixing mechanism 7 and the above ultrasonic device.
  • the fixing mechanism 7 is disposed on the base 1 and is used for fixing the limbs of the experimental animal.
  • One end of the dental hook 6 is hinged to the base 1 of the ultrasonic device, and the other end is provided with a card slot 61 for clamping the teeth of the experimental animal.
  • the ultrasonic device and the animal fixing device provided by the embodiment, wherein the ultrasonic device comprises a base 1 for use as a surgical operation platform, and an ultrasonic probe 2 for ultrasonic stimulation treatment of an experimental animal fixed on the base 1 (when used The ultrasonic probe 2 is connected to the device) and the regulating member for carrying the ultrasonic probe 2 and capable of adjusting the ultrasonic probe 2 to each position; wherein the animal fixing device comprises a fixing mechanism 7 for fixing the experimental animal to the base 1, A dental hook 6 for fixing the teeth of an experimental animal and the above-described ultrasonic device capable of ultrasonically stimulating treatment of an experimental animal fixed to the base 1 can be adjusted in various places.
  • the ultrasonic probe 2 is first adjusted to a position that does not hinder the surgical operation by controlling the adjustment member, and then the experimental animal is fixed on the base 1, wherein the fixing mechanism 7 is used to fix the limbs of the experimental animal, and the dental hook 6 passes the experiment.
  • the teeth of the animal are inserted into the card slot 61 to complete the fixation of the teeth of the experimental animal; after the experimental animal is fixed, the animal is subjected to a heart ligation operation or other surgery. After the operation is completed, the ligature is prepared to unwind the blood of the experimental animal.
  • a series of ultrasonic stimulation parameters of the ultrasound probe 2 are adjusted by means of a device connected to the ultrasound probe 2, and the adjustment component is adjusted to adjust the ultrasound probe 2 to the lesion site of the experimental animal, and the ultrasound is instantaneously opened for blood flow reperfusion of the animal.
  • the ultrasonically controllable fixed-point stimulation treatment can be realized at the instant of reperfusion, thereby improving the experimental precision and the therapeutic effect.
  • the setting of the flexible adjusting rod 3 can realize the adjustment of the various positions of the ultrasonic probe 2, and the ultrasonic probe 2 with the ultrasonic parameters set can be adjusted to the lesion part of the experimental animal in advance before the unclacing line is reperfused for the experimental animal. Therefore, the ultrasound can control the fixed-point stimulation treatment at the instant of reperfusion, and improve the experimental precision and therapeutic effect.
  • the adjusting component may be a flexible rod, and the ultrasonic probe 2 is adjusted by 360° by bending the flexible rod; or the vertical telescopic rod pivotally connected to the base 1 , and the vertical telescopic rod is slidably adjusted to have horizontal expansion and contraction
  • the rod, the horizontal telescopic rod can be adjusted up and down along the length direction of the vertical telescopic rod, the ultrasonic probe 2 is connected to the free end end of the horizontal telescopic rod, and the vertical telescopic rod is rotated circumferentially along the base 1 and the length of the vertical telescopic rod is vertical.
  • the height adjustment of the telescopic and horizontal telescopic rods on the vertical telescopic rod and the length expansion of the horizontal telescopic rods enable 360° adjustment of the ultrasonic probe 2; or other components that can achieve multi-directional adjustment;
  • the fixing mechanism 7 can The method of fixing the rope and fixing the buckle is adopted;
  • the ultrasonic probe 2 can perform the B-ultrasound imaging or the ultrasonic focusing stimulation on the lesion part of the experimental animal.
  • the fixed end of the flexible adjusting rod 3 can be connected to the base 1 by plugging, or can be screwed to the base 1.
  • a screw hole can be arranged on the base 1 at the fixed end of the flexible adjusting rod 3.
  • a screw is provided which matches the threaded hole.
  • the adjusting component may include a flexible adjusting rod 3, and the two ends of the flexible adjusting rod 3 are respectively a fixed end and an adjusting end, and the fixed end is detachably fixed on the base.
  • the ultrasonic probe 2 is detachably fixed to the adjustment end of the flexible adjustment rod 3.
  • the flexible adjusting rod 3 has a certain hardness, can ensure the support and bearing of the ultrasonic probe 2, and has deformability. The operator can apply the force to the flexible adjusting rod 3, bend the flexible adjusting rod 3, etc.
  • the probe 2 is adjusted in various positions, and the flexible adjustment rod 3 has a simple structure and convenient operation.
  • the adjustment end of the flexible adjustment rod 3 is detachably fixed with a probe holder 4, and the probe holder 4 includes an open collar 41, and the shape of the collar 41 and the ultrasonic probe 2 The shape is matched; the collar 41 is fixed with a connecting ear 42, and the connecting ear 42 is detachably fixed with the adjusting end of the flexible adjusting rod 3, and both end ends of the opening of the collar 41 are radially outward
  • the fastening ear 43 is fixed, and the collar 41 is provided with a locking member, and the locking member realizes the locking or loosening of the ultrasonic probe 2 in the collar 41 by controlling the distance between the two fastening ears 43;
  • the clamping member includes a third threaded fastener 44 and a nut.
  • the two fastening ears 43 are provided with corresponding through holes.
  • the third threaded fastener 44 passes through the two through holes in sequence, and the nut is screwed to the third thread.
  • the fastener 44 passes through one
  • the ultrasonic probe 2 is connected to the flexible adjustment rod 3, firstly connecting the connecting ear 42 of the probe holder 4 to the adjustment end of the flexible adjustment rod 3, specifically, the flexible adjustment rod
  • the adjusting end of the 3 is fixed with a screw
  • the connecting ear 42 of the probe holder 4 is provided with a threaded hole matched with the screw, and the connecting ear 42 is screwed onto the screw through the threaded hole; initially, the locking member is incorrect.
  • the fastening ear 43 is locked, and the collar 41 is provided with an opening.
  • the size of the inner ring of the collar 41 can be adjusted to a certain extent, the ultrasonic probe 2 is inserted into the collar 41, and then the locking member is adjusted to lock and tighten the two fastening ears.
  • the distance between the 43 is reduced, the inner ring of the collar 41 is reduced, and the ultrasonic probe 2 is locked and fixed in the collar 41.
  • the third threaded fastener 44 and the nut can be used for the locking member to fasten the third thread.
  • the member 44 passes through the through holes in the two fastening ears 43 at the opening of the collar 41 in turn, and screwes the nut on the third threaded fastener 44 until the two fastening ears 43 are locked to complete the collar 41. Fixed locking of the ultrasonic probe 2.
  • the probe clip 4 is detachably mounted on the flexible adjusting rod 3, and the corresponding probe clip 4 can be selected for different types of ultrasonic probes 2, and the inner ring size of the probe clip 4 collar 41 can be adjusted within a certain range, and can also be applied to different
  • the ultrasonic probe 2 of the model has improved convenience.
  • the ultrasonic device may further include a collimator 5, the outer wall of the ultrasonic probe 2 is provided with external threads, and the inner wall of the collimator 5 is provided with internal threads.
  • the internal thread matches the external thread.
  • the ultrasonic wave emitted by the ultrasonic probe 2 is reflected and diffused in various directions, and the collimator 5 can refract the reflected ultrasonic waves in a certain range into parallel waves and transmit them to the optical fiber, thereby being transmitted to the ultrasonic device, so that the ultrasonic device can receive the maximum.
  • the efficiency of the acoustic signal improves the accuracy of the ultrasonic treatment; in addition, the collimator 5 is filled with the coupling fluid of the ultrasonic transmission, and the collimator 5 is screwed to the ultrasonic probe 2, and the collimator 5 can be changed by the thread adjustment.
  • the distance between the ultrasonic probes 2, thereby adjusting the depth of the stimulation of the ultrasonic probe 2, achieves focus stimulation treatment on different depth parts of the experimental animal, no need to replace the different ultrasonic probes 2, the operation is convenient, and the utility of the ultrasonic device is improved.
  • a "T"-shaped groove 11 may be disposed on the base 1.
  • the end of the tooth hook 6 and the base 1 is provided with a sleeve 62, and the sleeve 62 is disposed inside.
  • the rotating shaft 63, the rotating shaft 63 is snapped into the "-" groove of the "T” shaped groove 11, and is slidable in the "-” groove, and the tooth hook 6 protrudes through the "
  • the upper surface of the base 1; preferably, one end of the "T" shaped groove 11 communicates with the outside.
  • the rotating shaft 63 is first passed through the sleeve 62 of the tooth hook 6, and the tooth hook 6 can be rotated about the rotating shaft 63, and then the rotating shaft 63 is inserted into the "-" groove of the "T” shaped groove 11, and the rotating shaft 63 is extended at both ends.
  • the position of the output sleeve 62 is caught in the "-” groove, and can be slid along the length of the "T" groove 11 in the "-” groove, and the tooth hook 6 passes through the "
  • the upper surface of the base 1 fixes the teeth of the experimental animal.
  • the tooth hook 6 can be carried to move, so that the card slot 61 on the tooth hook 6 can be different from different experimental animals.
  • the teeth are matched and the teeth are fixed to different animals, thereby improving the utility of the animal fixture; preferably, one end of the "T" shaped groove 11 communicates with the outside, and when the tooth hook 6 is mounted, it is only required to be mounted on the tooth hook 6
  • the shaft 63 in the sleeve 62 can be inserted from the end of the "T"-shaped groove 11 that communicates with the outside, and is easy to install.
  • the card slot 61 on the tooth hook 6 may be an elongated card slot 61.
  • the length direction of the card slot 61 is perpendicular to the direction of movement of the tooth hook 6 along the "-" slot, so that the teeth of the experimental animal are in the card slot 61.
  • a large range in the longitudinal direction can be caught in the card slot 61, improving the utility of the tooth hook 6.
  • a rectangular block 64 may be connected to both ends of the rotating shaft 63, and both rectangular blocks 64 are locked into the "-" slot, and can be in the " - “sliding in the groove;
  • the base 1 is provided with a first pressing member for pressing or loosening the rectangular block 64 in the "-" groove; preferably, the first pressing member comprises the first thread
  • the fastener 13 has two rows of first threaded holes 12 along the length of the "T" shaped groove 11 on the base 1. Each of the first threaded holes 12 is penetrated by a "-" groove, and the first threaded fastener 13 is threaded. Fitted into the first threaded bore 12 and pressed against the corresponding rectangular block 64.
  • the rectangular block 64 is more closely matched with the end of the cylindrical rotating shaft 63 in the "-" groove to improve the connection stability of the rotating shaft 63 and the base 1. Initially, the first pressing member is not locked with the rectangular block. 64, the rectangular block 64 can be adjusted along the length direction of the "-" slot. After the adjustment is completed, the first pressing member is locked to lock the rectangular block 64, and the positions of the rectangular block 64 and the rotating shaft 63 are fixed on the base 1 to reduce the teeth.
  • the first pressing member may select the first threaded fastener 13 to relax and compress the rectangular block 64 by adjusting the depth of the first threaded fastener 13 into the first threaded hole 12.
  • the first threaded holes 12 are arranged in two rows and arranged along the length direction of the "T" shaped groove, and the operator can select the corresponding first threaded hole 12 according to the position of the rectangular block 64 after the adjustment is completed, and secondly, two The first threaded fasteners 13 simultaneously press and fix the two rectangular blocks 64 at both ends of the rotating shaft 63, further improving the fixing stability of the tooth hooks 6.
  • the fixing mechanism 7 may include a pressing plate 71 and a second pressing member, and the pressing plate 71 includes an outwardly convex curved plate 711 and is fixed on the curved plate.
  • the second pressing member is used for pressing the connecting plate 712 against the base 1; preferably, the second pressing member comprises a second threaded fastener 72, and the connecting plate 712 is provided with a through hole
  • the second threaded hole 14 is disposed on the base 1 , and the second threaded fastener 72 is threadedly connected to the second threaded hole 14 through the through hole; the pressure plate 71 is five, and the second threaded hole 14 is corresponding to five groups, and five
  • the second threaded holes 14 of the set correspond to the limbs and tail positions of the experimental animals, respectively.
  • the pressing plate 71 is not pressed by the second pressing member, and when the experimental animal is fixed by the fixing mechanism 7, the limbs or tails of the experimental animal are extended into the curved space formed by the curved plate 711 of the pressing plate 71, and then Adjusting the second pressing member presses the connecting plate 712 against the base 1 to complete the fixing of the limbs and the tail of the experimental animal.
  • the second pressing member may be a second threaded fastener 72, and the second threaded fastener 72 is passed through the through hole of the pressing plate 71 connecting plate 712 and aligned with the corresponding second thread on the base 1.
  • the hole 14 is screwed therein, and the two connecting plates 712 at both ends of the pressing plate 71 are respectively provided with a second threaded fastener 72, and the second threaded fastener 72 presses the two ends of the pressing plate 71 to improve the pressing plate 71.
  • the tightness of the compaction ensures that the pressure plate 71 is fixed to the experimental animals.
  • the pressure plate 71 is divided into five groups, and the limbs and tails of the experimental animals are respectively fixed.
  • each set of second threaded holes 14 includes a plurality of rows of second threaded holes 14, each of which is arranged along the length of the limbs or tail of the laboratory animal.
  • Each set of second threaded holes 14 includes a plurality of rows of second threaded holes 14, each row being provided with two second threaded holes 14 respectively corresponding to the through holes in the platen 712 of the pressure plate 71, and the plurality of rows of second threaded holes 14 are along
  • the limbs or tails of the experimental animals are arranged in the longitudinal direction to accommodate the different sizes of the experimental animals, and the limbs and tails are fixed on the base 1 to fix the experimental animals, thereby further improving the utility of the animal fixture.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Animal Husbandry (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Catching Or Destruction (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

L'invention concerne un dispositif ultrasonore et un dispositif de fixation d'animal. Le dispositif ultrasonore comprend : une base (1), une sonde à ultrasons (2), et un composant de réglage (3) reliant la base (1) et la sonde à ultrasons (2). Le composant de réglage (3) entraîne la sonde à ultrasons (2) à s'ajuster dans n'importe quelle direction. Le dispositif de fixation d'animal comprend : un crochet de dent (6), un mécanisme de fixation (7), et le dispositif ultrasonore. Le mécanisme de fixation (7) est disposé sur la base (1) et sert à fixer quatre membres d'un animal sous expérience. Une extrémité du crochet de dent (6) est reliée de manière articulée à la base (1) du dispositif ultrasonore, et l'autre extrémité est pourvue d'une fente (61) pour maintenir étroitement une dent de l'animal sous expérience. Le composant de réglage (3) est configuré pour effectuer le réglage de la sonde à ultrasons (2) dans n'importe quelle direction. Avant que la ligature ne soit relâchée et que l'animal sous expérience est re-perfusé, la sonde ultrasonore (2) ayant des paramètres ultrasonores configurés est déplacée vers une lésion de l'animal sous expérience à l'avance de telle sorte que, lorsque la re-perfusion se produit, un traitement de stimulation spécifique à un site pouvant être commandé par ultrasons est effectué, ce qui permet d'améliorer la précision expérimentale et l'efficacité de traitement.
PCT/CN2017/120103 2017-12-13 2017-12-29 Dispositif ultrasonore et dispositif de fixation d'animal WO2019114046A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201711335747.2A CN109907856A (zh) 2017-12-13 2017-12-13 超声装置及动物固定装置
CN201711335747.2 2017-12-13

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WO2019114046A1 true WO2019114046A1 (fr) 2019-06-20

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Cited By (1)

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CN112675443A (zh) * 2020-12-23 2021-04-20 燕山大学 一种用于动物脑损伤超声治疗的固定装置及其方法

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CN111449796A (zh) * 2020-05-11 2020-07-28 华中科技大学同济医学院附属协和医院 一种实验鼠解剖装置及其使用方法
CN112155783B (zh) * 2020-10-22 2022-08-02 佛山市振耀金属科技有限公司 一种可灵活调节的兽医用宠物固定台

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