WO2019111723A1 - Composition de dentifrice - Google Patents
Composition de dentifrice Download PDFInfo
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- WO2019111723A1 WO2019111723A1 PCT/JP2018/043143 JP2018043143W WO2019111723A1 WO 2019111723 A1 WO2019111723 A1 WO 2019111723A1 JP 2018043143 W JP2018043143 W JP 2018043143W WO 2019111723 A1 WO2019111723 A1 WO 2019111723A1
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- WIPO (PCT)
- Prior art keywords
- mass
- acid
- toothpaste composition
- salts
- sodium
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- the present invention relates to a toothpaste composition which contains a water-soluble copper compound and anhydrous silicic acid, is excellent in deodorizing effect and is maintained even after storage, and is excellent in appearance stability and suitable for breath malodor control.
- Patent Documents 1 to 3 Patent No. 2569639, Patent No. 2540892, and Japanese Patent No. 2540895.
- anhydrous silica such as abrasive silica and thickening silica is generally used for the purpose of imparting cleaning power and giving appropriate viscosity. If the condition inside is weak, such as teeth or gums, it may cause unpleasant irritation. In recent years, considering the increasing oral environment of the elderly, it is possible to reduce the influence on aging weakened teeth and gum tissue, that is, to suppress the compounding amount of anhydrous silicic acid which may have an influence relatively small. Also, it has been desired that the deodorizing action and the like by the water-soluble copper compound be effectively developed to prevent bad breath and the like.
- the present invention has been made in view of the above circumstances, and provides a toothpaste composition which contains a water-soluble copper compound and anhydrous silicic acid, is excellent in deodorizing effect, is maintained even after storage, and is excellent in appearance stability.
- the purpose is
- a toothpaste composition containing (A) a water-soluble copper compound in a specific amount and (B) anhydrous silica in a specific amount or less (C) a specific anionic surfactant and (D) a wetting agent selected from a specific polyhydric alcohol in a specific amount, and (E) a specific carboxylic acid or a salt thereof, E) (A) is blended so that the mass ratio is within a specific range, and when the content of Sorbit in the composition is less than a specific amount, the deodorizing effect particularly against bad breath is excellent and maintained after storage
- the present invention provides a toothpaste composition having excellent appearance stability and good taste, whereby it is possible to effectively suppress or prevent bad breath even with a relatively small amount of anhydrous silicic acid. It came to eggplant.
- the deodorizing effect is improved when the mass ratio of (E) / (A) is within a specific range. And the stabilization of the appearance of the preparation are compatible with each other, giving a remarkable effect. More specifically, when the present inventors examined the combined use of a water-soluble copper compound and anhydrous silicic acid in a toothpaste composition, the deodorizing effect was reduced particularly during storage, liquid separation, discoloration, and further.
- (A) is a phenomenon uniquely generated by the water-soluble copper compound when the blending amount of silicic anhydride is below a certain value.
- components (C) and (D) are blended in specific amounts together with components (A) and (B), and component (E) is blended in an appropriate ratio to component (A).
- the toothpaste composition of the present invention has a deodorizing ability (immediately after preparation), a deodorizing ability maintaining effect during storage, and a precipitate suppressing effect (no precipitates) as shown in the examples described later.
- the absence of liquid separation and the absence of discoloration are excellent, and the absence of metallic taste is also excellent.
- Patent Documents 4 to 6 do not mention at all the occurrence of brown precipitates in a system in which the blending amount of anhydrous silicic acid is equal to or less than a specific value.
- Patent documents 7 to 9 Japanese Patent No. 2580656, JP-A-4-15211, Japanese Patent No. 3922329) disclose a toothpaste composition containing a water-soluble copper compound and an anhydrous silicic acid, There is no mention of brown precipitates. From Patent Documents 1 to 9, it is not possible to predict the suppression of brown precipitates and the remarkable effect of the present invention by the combination of the components (A), (B), (C), (D) and (E).
- the present invention provides the following toothpaste composition.
- [1] (A) 0.05 to 1% by mass of a water-soluble copper compound, (B) 5 to 20% by mass of anhydrous silicic acid, (C) 0.5 to 2% by mass of one or more anionic surfactants selected from acyl taurine, acyl amino acids and salts thereof (D) 24 to 55% by mass of one or more wetting agents selected from glycerin, propylene glycol and polyethylene glycol having an average molecular weight of 630 or less And (E) a dicarboxylic acid, a tricarboxylic acid and one or more selected from alkali metal salts thereof, wherein (E) / (A) has a mass ratio of 0.4 to 10, and a composition A toothpaste composition containing no more than 10% by mass of sorbite or no sorbite therein.
- the component (C) is one or more anionic surfactants selected from acyl taurine salts, acyl glutamate salts and acyl alanine salts in which the acyl group has 8 to 18 carbon atoms [1] to [1] The dentifrice composition in any one of 4].
- a toothpaste composition containing a water-soluble copper compound and an anhydrous silicic acid, which is excellent in the deodorizing effect and maintained even after storage, and is excellent in the appearance stability.
- This toothpaste composition can effectively suppress or prevent bad breath without adversely affecting the weakened tooth and gum tissue by suppressing the amount of anhydrous silica relatively, and it can be used for suppressing bad breath It is effective as
- the toothpaste composition of the present invention comprises (A) a water-soluble copper compound, (B) anhydrous silica, (C) a specific anionic surfactant, and (D) a specific anionic surfactant. And (E) a specific carboxylic acid or a salt thereof.
- the water soluble copper compound (A) is a deodorizing agent and is preferably a water soluble copper salt such as copper gluconate, copper citrate and copper sulfate. These may be used alone or in combination of two or more.
- the compounding amount of the water-soluble copper compound (A) is 0.05 to 1% (% by mass, hereinafter the same) of the whole composition, and preferably 0.1 to 0.5%. If it is less than 0.05%, the deodorizing ability is inferior. If it exceeds 1%, the metallic taste may be enhanced to the extent that masking is difficult, and there may be separation of the solution during storage and discoloration of the preparation to the extent that inhibition is difficult.
- abrasive silica and / or thickening silica blended for the purpose of imparting cleaning power and holding properties of the preparation can be used, and abrasive silica or thickening silica may be used.
- abrasive silica examples include anhydrous silicic acid such as precipitated silica and pyrogenic silica, and compounds having as a main component silicate such as aluminosilicate, zirconosilicate, and titanium-binding silica. These may be used alone or in combination of two or more.
- abrasive silica one having a median diameter (d50) of preferably 5 to 40 ⁇ m, particularly 10 to 30 ⁇ m using volume average may be used.
- the median diameter of the above-mentioned silica is a value measured using a particle size distribution measuring apparatus (manufactured by Nikkiso Co., Ltd., Microtrac particle size distribution analyzer, dispersion medium; water) (the same applies hereinafter).
- the thickening silica it is preferable to use one or two or more silicas obtained by a known method such as precipitated silica and pyrogenic silica having a liquid absorption volume in the range of 2 to 3 ml / g. it can.
- Thickening silica has a liquid absorption as described above, while the liquid absorption of abrasive silica is usually less than 2 ml / g.
- the method of measuring the above-mentioned liquid absorption amount is as follows (same below). Weigh 1.0 g of the sample on a clean glass plate, and mix it with a stainless steel spatula using a microburette while adding 42.5% glycerin little by little. The amount of liquid (ml) required for the sample to become one lump and to be peeled off from the glass plate with a spatula is defined as the amount of liquid absorbed.
- the blending amount of (B) anhydrous silicic acid is 5 to 20%, preferably 7 to 18%, more preferably 10 to 15% of the whole composition. If it is less than 5%, sufficient cleaning power and shape retention can not be obtained. If it exceeds 20%, the deodorizing power decreases. In addition, generation
- the abrasive silica is contained within the range of the amount of the component (B), the content thereof is preferably 5 to 19.9%, particularly 5 to 15%, especially 5 to 12% of the whole composition. %, And when it contains a thickening silica, its content is preferably 0.1 to 15%, in particular 0.1 to 10%, especially 1 to 8%, of the total composition.
- Component (C) is one or more anionic surfactants selected from acyl taurine, acyl amino acids and salts thereof.
- the component (C) is preferably selected from an acyl taurine salt, an acyl glutamate salt and an acyl alanine salt each having an acyl group having 8 to 18 carbon atoms, particularly 12 to 16 carbon atoms, among them an acyl taurine Salts, acyl glutamates, especially acyl taurine salts are preferred.
- these salts are alkali metal salts such as sodium and potassium, alkaline earth metal salts, organic amine salts and the like, and particularly preferably sodium salts.
- acyl taurine salt examples include sodium lauroyl methyl taurine, myristoyl methyl taurine sodium, coconut oil fatty acid methyl taurine sodium and the like.
- acyl glutamate salt examples include sodium lauroyl glutamate, sodium myristoyl glutamate, coconut oil fatty acid acyl potassium glutamate and the like.
- acyl alanine salt sodium lauroyl methyl alanine and the like can be mentioned. Commercially available products can be used.
- NIKKOL LMT sodium lauroyl methyl taurine, Nikko Chemicals Co., Ltd.
- NIKKOL MMT myristoyl methyl taurine sodium, Nikko Chemicals Co., Ltd.
- aminosurfact ALMS-P1 N-Lauroyl-L-glutamate sodium, Asahi Kasei Chemicals Co., Ltd.
- Amisoft LS-11 N-lauroyl-L-glutamate sodium, Ajinomoto Healthy Supply Co., Ltd.
- Aminosurfact AMMS-P1 N-Myristoyl-L Sodium glutamate, Asahi Kasei Chemicals Co., Ltd., Amisoft MS-11 (N-myristoyl-L-glutamate sodium, Ajinomoto Healthy Supply Co., Ltd.)
- NIKKOL alaninate LN-30 laauroylmethyl- ⁇ ) Sodium alanine, and Nikko Chemicals Co.
- the blending amount of the component (C) is 0.5 to 2%, preferably 0.6 to 1.5%, more preferably 0.8 to 1.5% of the whole composition. If the amount is less than 0.5%, the effect of suppressing precipitates during storage and the effect of reducing metallic taste are inferior. Moreover, it may be inferior to foamability. If it exceeds 2%, the bitterness of the component (C) may be so strong that masking is difficult, and the feeling of use may be reduced.
- anionic surfactants other than the above component (C) may be blended as long as the effects of the present invention are not impaired, but in particular, no alkyl sulfate such as sodium lauryl sulfate is blended.
- the blending amount is preferably 0.5% or less, particularly 0.2% or less, especially 0.1% or less of the whole composition.
- Component (D) is one or more wetting agents selected from glycerin, propylene glycol and polyethylene glycol having an average molecular weight of 630 or less, and glycerin is particularly preferable. When using 2 or more types, it is preferable to combine glycerol and propylene glycol or the said polyethylene glycol.
- the polyethylene glycol has an average molecular weight (average molecular weight described in the quasi-drug raw material standard 2006, the same applies hereinafter) is 630 or less, preferably 600 or less, more preferably 200 to 600, still more preferably 300 to 600.
- examples of the polyethylene glycol include polyethylene glycol 200 (average molecular weight 190 to 210), polyethylene glycol 300 (average molecular weight 280 to 320), polyethylene glycol 400 (average molecular weight 380 to 420), and polyethylene glycol 600 (average molecular weight 570 to 630). Commercially available products can be used.
- the compounding amount of the component (D) is 24 to 55%, preferably 28 to 50%, more preferably 32 to 45% of the whole composition, from the viewpoint of liquid separation suppression. If the blending amount is less than 24%, the liquid separation suppressing effect is inferior. If it exceeds 55%, discoloration of the preparation upon storage is aggravated. In addition, the dispersibility of the preparation in the oral cavity may be deteriorated to lower the usability.
- the blending amount is preferably 21% or more, particularly 25% or more of the whole composition as a pure part.
- sugar alcohols such as sorbite and xylit can be further blended.
- the blending amount of the sugar alcohol is preferably such that the total amount with the (D) component is within the range of the blending amount of the (D) component.
- the content of sorbite in the sugar alcohol is 10% or less, preferably 8% or less, particularly 4% or less of the whole composition, and no blending is carried out. % Is particularly preferred. If it is added in excess of 10%, the effect of maintaining the deodorizing ability upon storage will decrease, and the color change of the preparation upon storage will also deteriorate.
- the component (E) is one or more carboxylic acids or salts thereof selected from dicarboxylic acids, tricarboxylic acids and alkali metal salts thereof. These are known as chelating agents, but in the present invention, they contribute to the maintenance effect of the deodorizing ability during storage and the precipitation suppression effect during storage.
- carboxylic acids or salts thereof selected from dicarboxylic acids, tricarboxylic acids and alkali metal salts thereof. These are known as chelating agents, but in the present invention, they contribute to the maintenance effect of the deodorizing ability during storage and the precipitation suppression effect during storage.
- citric acid, succinic acid, malic acid, tartaric acid and alkali metal salts thereof are preferable, and citric acid or an alkali metal salt thereof is more preferable.
- the compounding amount of the component (E) is mainly determined by the mass ratio of (E) / (A) shown below and can be set to satisfy the mass ratio of (E) / (A), but preferably the composition It is 0.02 to 3% of the whole, in particular 0.05 to 2%.
- the maintenance effect of the deodorizing power at the time of storage, and the precipitation inhibitory effect at the time of storage are fully acquired as it is 0.02% or more.
- the fall of the deodorizing ability especially immediately after preparation can be fully prevented as it is 3% or less, and the expression of the offensive taste derived from (E) component can fully be prevented especially.
- (E) / (A) which indicates the blending ratio of the component (E) to the component (A), is a mass ratio of 0.4 to 10, preferably 0.5 to 6, and more preferably 0. 6 to 5, more preferably 0.7 to 5. Within this range, the deodorizing power and the maintenance effect of the deodorizing power are excellent, and the precipitate suppressing effect during storage is excellent. When the mass ratio of (E) / (A) is less than 0.4, the effect of maintaining the deodorizing ability during storage and the effect of suppressing precipitates are inferior. If it exceeds 10, the deodorizing ability immediately after preparation is reduced.
- abrasives other than anhydrous silicic acid can be blended.
- caking agents other than anhydrous silicic acid can be blended.
- surfactants other than anionic surfactants can be blended.
- sweeteners, colorants, preservatives, perfumes, water-soluble copper Active ingredients other than compounds can be blended.
- calcium phosphate based compounds such as dibasic calcium phosphate dihydrate or anhydrous, monobasic calcium phosphate, tribasic calcium phosphate, calcium carbonate, calcium hydroxide, aluminum hydroxide, insoluble sodium metaphosphate, synthetic resin system
- An abrasive is mentioned.
- the blending amount thereof is preferably 1 to 15%, and may be 0% without blending.
- the caking agent examples include cellulose derivatives such as sodium carboxymethyl cellulose, methyl cellulose, hydroxymethyl cellulose and hydroxyethyl cellulose, alginic acid derivatives such as sodium alginate, gums such as xanthan gum, carrageenan, polyvinyl alcohol and organic caking such as sodium polyacrylate Agents.
- the blending amount of the caking agent is usually 0.1 to 5%.
- nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid esters, sugar alcohol fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene cured castor oil and the like
- sugar fatty acid esters such as sucrose fatty acid esters, sugar alcohol fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene cured castor oil and the like
- examples thereof include polyoxyethylene fatty alcohol esters such as oxyethylene fatty acid ester and polyoxyethylene stearyl ether, and fatty acid alkanolamides such as lauric acid diethanolamide.
- cationic surfactants include alkyl ammonium types such as distearylmethyl ammonium chloride, and alkyl benzyl ammonium salts.
- Amphoteric surfactants include alkyl betaines, betaine acetates such as alkyldimethylaminoacetic acid betaines and fatty acid amidopropyl betaines, betaines such as alkylimidazolinium betaines, and imidazolines.
- the blending amount of these surfactants is usually from 0 to 10%, particularly from 0.01 to 5%.
- saccharin sodium etc. are mentioned
- coloring agent blue No. 1, yellow No. 4, titanium dioxide etc.
- preservatives include p-oxybenzoic acid esters such as methyl p-hydroxybenzoate, benzoic acid or salts thereof.
- peppermint oil As flavoring agents, peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, mint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Processing of natural flavors such as oil, soy sauce, iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural flavors (pre-cut, pre-cut, fractional distillation, liquid-liquid extraction, essence, powder Perfumes, etc.), and menthol, Bonnet, anethole, cineole, methyl salicylate, cinnamic aldehyde, eugenol, 3-
- the active ingredients include nonionic bactericidal agents such as isopropylmethylphenol, cationic bactericidal agents such as cetyl pyridinium chloride and benzalkonium chloride, tranexamic acid, anti-inflammatory agents such as epsilon aminocaproic acid and allantoin, dextranase etc. Enzymes, fluorine-containing compounds such as sodium fluoride and sodium monofluorophosphate, vitamins such as ascorbic acid and tocopherol acetate, dipotassium glycyrrhizinate, potassium nitrate, aluminum lactate, sodium chloride and plant extracts such as thyme .
- the said active ingredient can be mix
- Example Comparative Example
- the dentifrice composition (toothpaste) having the composition shown in Tables 1 to 3 was prepared by a conventional method and evaluated by the following method. The results are shown in the table.
- the deodorizing rate (%) was determined based on the following equation.
- the gas chromatography conditions are as follows. Equipment: GC-2014 (manufactured by Shimadzu Corporation) Detector: FPD Separation column: Teflon (registered trademark), packing material Chromosorb W 60/80 AW-DM, CS processing (made by Shinwa Kako Co., Ltd.) Inlet temperature: 130 ° C Column temperature: 80 ° C Detector temperature: 150 ° C Carrier gas: N 2 Carrier gas flow rate: 50 mL / min
- the deodorizing power (immediately after preparation) was evaluated based on the following judgment criteria from the deodorizing rate determined.
- Judgment criteria ⁇ : 90% or more and 100% or less ⁇ : 70% or more and less than 90% ⁇ : 50% or more and less than 70% ⁇ : less than 50%
- Judgment criteria No discoloration is observed in comparison to the -5 ° C stored product ⁇ : A slight change in color is observed but no problem compared to the -5 ° C stored product ⁇ : -5 ° C stored product and Discoloration is observed by comparison. X: Discoloration is highly observed compared to the -5 ° C preservation product.
- the toothpaste of the formulation example has good deodorizing ability (immediately after preparation), deodorizing effect during storage, precipitate suppressing effect, absence of liquid separation and no discoloration, and no metallic taste.
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Abstract
La présente invention concerne une composition de dentifrice qui contient un composé de cuivre soluble dans l'eau et de l'anhydride silicique, qui a un excellent effet désodorisant et qui est capable de conserver ledit effet même après avoir été stockée, qui présente une stabilité d'apparence supérieure, et qui est appropriée pour supprimer une mauvaise haleine. Cette composition de dentifrice comprend (A) 0,05 à 1 % en masse d'un composé de cuivre soluble dans l'eau, (B) 5 à 20 % en masse d'anhydride silicique, (C) 0,5 à 2 % en masse d'un ou de plusieurs types de tensioactifs anioniques choisis parmi la taurine d'acyle, l'acide acylaminé, et les sels de ces composés, (D) 24 à 55 % en masse d'un ou de plusieurs types d'agents d'humidification choisis parmi la glycérine, le propylène glycol, et les polyéthylène glycols ayant un poids moléculaire moyen d'au plus 630, et (E) un ou plusieurs parmi l'acide dicarboxylique, l'acide tricarboxylique, et les sels de métaux alcalins de ces acides, le rapport en masse (E)/(A) étant de 0,4 à 10, et la composition contenant au plus 10 % en masse de sorbitol ou ne contenant pas de sorbitol.
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56169619A (en) * | 1980-04-29 | 1981-12-26 | Blendax Werke Schneider Co | Tooth paste composition |
JPH01168610A (ja) * | 1987-12-24 | 1989-07-04 | Lion Corp | 口腔用組成物 |
JPH01168611A (ja) * | 1987-12-24 | 1989-07-04 | Lion Corp | 口腔用組成物 |
JP2003231621A (ja) * | 2002-02-06 | 2003-08-19 | Lion Corp | 口臭予防用口腔用組成物 |
JP2018145163A (ja) * | 2017-03-09 | 2018-09-20 | ライオン株式会社 | 歯磨剤組成物 |
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Publication number | Priority date | Publication date | Assignee | Title |
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RU2414210C1 (ru) * | 2009-12-28 | 2011-03-20 | Общество С Ограниченной Ответственностью "Сплат-Косметика" (Ооо "Сплат-Косметика") | Средство для удаления табачных смол и композиции на его основе |
JP5891749B2 (ja) * | 2011-11-30 | 2016-03-23 | ライオン株式会社 | 歯磨剤組成物 |
US10123953B2 (en) * | 2012-06-21 | 2018-11-13 | The Procter & Gamble Company | Reduction of tooth staining derived from cationic antimicrobials |
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2017
- 2017-12-07 JP JP2017235060A patent/JP7000823B2/ja active Active
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2018
- 2018-11-22 CN CN201880051468.XA patent/CN111031999B/zh active Active
- 2018-11-22 WO PCT/JP2018/043143 patent/WO2019111723A1/fr active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56169619A (en) * | 1980-04-29 | 1981-12-26 | Blendax Werke Schneider Co | Tooth paste composition |
JPH01168610A (ja) * | 1987-12-24 | 1989-07-04 | Lion Corp | 口腔用組成物 |
JPH01168611A (ja) * | 1987-12-24 | 1989-07-04 | Lion Corp | 口腔用組成物 |
JP2003231621A (ja) * | 2002-02-06 | 2003-08-19 | Lion Corp | 口臭予防用口腔用組成物 |
JP2018145163A (ja) * | 2017-03-09 | 2018-09-20 | ライオン株式会社 | 歯磨剤組成物 |
Also Published As
Publication number | Publication date |
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CN111031999A (zh) | 2020-04-17 |
JP2019099532A (ja) | 2019-06-24 |
JP7000823B2 (ja) | 2022-01-19 |
CN111031999B (zh) | 2023-03-28 |
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