WO2019108047A3 - 탈모의 예방 또는 치료용 조성물 - Google Patents

탈모의 예방 또는 치료용 조성물 Download PDF

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Publication number
WO2019108047A3
WO2019108047A3 PCT/KR2018/015202 KR2018015202W WO2019108047A3 WO 2019108047 A3 WO2019108047 A3 WO 2019108047A3 KR 2018015202 W KR2018015202 W KR 2018015202W WO 2019108047 A3 WO2019108047 A3 WO 2019108047A3
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WO
WIPO (PCT)
Prior art keywords
composition
prevention
treatment
hair
hair loss
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PCT/KR2018/015202
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English (en)
French (fr)
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WO2019108047A2 (ko
Inventor
김범석
김정호
Original Assignee
주식회사 굳티셀
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Application filed by 주식회사 굳티셀 filed Critical 주식회사 굳티셀
Priority to CN201880077942.6A priority Critical patent/CN111465611A/zh
Priority to EP18883020.2A priority patent/EP3719032A4/en
Priority to JP2020529401A priority patent/JP2021504407A/ja
Priority to US16/768,051 priority patent/US11890364B2/en
Publication of WO2019108047A2 publication Critical patent/WO2019108047A2/ko
Publication of WO2019108047A3 publication Critical patent/WO2019108047A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

본 발명은 탈모의 예방 또는 치료용 조성물에 관한 것으로, 표적 부위인 탈모 부위의 모유두 세포 내로 효과적으로 전달되어, 상기 탈모 부위에서 높게 발현되는 사이토카인 또는 효소에 의해 상기 조성물 내에 포함된 화합물로부터 약물이 분리되어 효과적으로 활성을 나타냄에 따라 최종적으로는 육모 및/또는 발모를 촉진할 수 있다.
PCT/KR2018/015202 2017-12-01 2018-12-03 탈모의 예방 또는 치료용 조성물 WO2019108047A2 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201880077942.6A CN111465611A (zh) 2017-12-01 2018-12-03 预防或治疗脱发的组合物
EP18883020.2A EP3719032A4 (en) 2017-12-01 2018-12-03 COMPOSITION FOR THE PREVENTION OR TREATMENT OF HAIR LOSS
JP2020529401A JP2021504407A (ja) 2017-12-01 2018-12-03 脱毛の予防または治療用組成物
US16/768,051 US11890364B2 (en) 2017-12-01 2018-12-03 Composition for prevention or treatment of hair loss

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2017-0164440 2017-12-01
KR20170164440 2017-12-01

Publications (2)

Publication Number Publication Date
WO2019108047A2 WO2019108047A2 (ko) 2019-06-06
WO2019108047A3 true WO2019108047A3 (ko) 2019-07-18

Family

ID=66665715

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/015202 WO2019108047A2 (ko) 2017-12-01 2018-12-03 탈모의 예방 또는 치료용 조성물

Country Status (6)

Country Link
US (1) US11890364B2 (ko)
EP (1) EP3719032A4 (ko)
JP (1) JP2021504407A (ko)
KR (3) KR20190065178A (ko)
CN (1) CN111465611A (ko)
WO (1) WO2019108047A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220084056A (ko) * 2019-09-19 2022-06-21 씨젠 인크. 내재화된 생물학적 활성 화합물 컨쥬게이트로부터의 선택적 약물 방출
CN114931546A (zh) * 2022-04-20 2022-08-23 江苏联环药业股份有限公司 一种用于防治雄激素性脱发的爱普列特外用制剂

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WO1999065483A1 (en) * 1998-05-05 1999-12-23 Astrazeneca Ab Mycobacterial inhibitors
US20090203574A1 (en) * 2006-05-31 2009-08-13 Elaine Fuchs Method for Modulating Hair Growth
KR101349300B1 (ko) * 2012-04-03 2014-02-13 연세대학교 산학협력단 비멘틴을 포함하는 탈모 억제 또는 발모 촉진용 조성물
KR20140060842A (ko) * 2012-11-12 2014-05-21 주식회사 한독 탈모증의 예방, 치료 또는 개선용 조성물
US20140186379A1 (en) * 2007-01-29 2014-07-03 Procell Therapeutics Inc. Novel macromolecule transduction domains and methods for identification and uses thereof

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WO2006098422A1 (ja) * 2005-03-14 2006-09-21 Nippon Medical School Foundation 細胞死抑制活性強化タンパク質fnkを用いた脱毛の防止
KR101095841B1 (ko) * 2009-02-19 2011-12-21 주식회사 나이벡 표적 선택적 세포／조직 투과기능 활성을 가지는 펩타이드 및 그 용도
WO2011041897A1 (en) * 2009-10-06 2011-04-14 Angiochem Inc. Compositions and methods for the transport of therapeutic agents
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Publication number Priority date Publication date Assignee Title
WO1999065483A1 (en) * 1998-05-05 1999-12-23 Astrazeneca Ab Mycobacterial inhibitors
US20090203574A1 (en) * 2006-05-31 2009-08-13 Elaine Fuchs Method for Modulating Hair Growth
US20140186379A1 (en) * 2007-01-29 2014-07-03 Procell Therapeutics Inc. Novel macromolecule transduction domains and methods for identification and uses thereof
KR101349300B1 (ko) * 2012-04-03 2014-02-13 연세대학교 산학협력단 비멘틴을 포함하는 탈모 억제 또는 발모 촉진용 조성물
KR20140060842A (ko) * 2012-11-12 2014-05-21 주식회사 한독 탈모증의 예방, 치료 또는 개선용 조성물

Also Published As

Publication number Publication date
EP3719032A4 (en) 2021-09-01
EP3719032A2 (en) 2020-10-07
US11890364B2 (en) 2024-02-06
KR20220099934A (ko) 2022-07-14
US20200352839A1 (en) 2020-11-12
CN111465611A (zh) 2020-07-28
KR102416354B1 (ko) 2022-07-05
KR20200131792A (ko) 2020-11-24
WO2019108047A2 (ko) 2019-06-06
KR20190065178A (ko) 2019-06-11
JP2021504407A (ja) 2021-02-15

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