WO2019101075A1 - Dispositif de dérivation endovasculaire aortique - Google Patents
Dispositif de dérivation endovasculaire aortique Download PDFInfo
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- WO2019101075A1 WO2019101075A1 PCT/CN2018/116542 CN2018116542W WO2019101075A1 WO 2019101075 A1 WO2019101075 A1 WO 2019101075A1 CN 2018116542 W CN2018116542 W CN 2018116542W WO 2019101075 A1 WO2019101075 A1 WO 2019101075A1
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- aortic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
Definitions
- the invention belongs to the technical field of medical instruments, and relates to a shunt and a stent thereof, in particular to an intra-aortic shunt.
- Aortic aneurysm refers to a local or diffuse abnormal expansion of the aortic wall, which causes symptoms by pressing the surrounding organs, and the tumorous rupture is its main risk. Often occurs in the ascending aorta arch, thoracic descending aorta, thoracic and abdominal aorta, and abdominal aorta. Aortic aneurysm can be divided into true aortic aneurysm and pseudo aortic aneurysm according to structure. Aortic aneurysm causes an increase in intravascular pressure, so it is progressively enlarged. If it develops for a long time, it will eventually rupture. The larger the tumor, the more likely it is to rupture. According to statistics, 90% of thoracic aortic aneurysms die within 5 years without surgery, and 75% of abdominal aortic aneurysms die within 5 years.
- Aortic dissection is another serious aortic disease.
- Aortic dissection refers to the destruction of the medial thoracic aorta, hemorrhage in the vessel wall, and blood entering between the media and the adventitia of the vessel wall. Due to the impact of blood flow, once the aortic dissection is formed, the tear can be extended in the direction of blood flow, the interlayer and the false lumen are enlarged, and the true cavity is compressed. Therefore, the possible risks of patients with aortic dissection include: (1) the threat of complete rupture of the blood vessel, and the death rate is extremely high once the blood vessel is completely ruptured; (2) the interlayer is gradually enlarged, and the true cavity is compressed to provide blood supply to the distal end of the blood vessel. cut back.
- the aortic dissection is secondary to a thoracic aortic aneurysm or coexisting with an aortic aneurysm.
- Oxford vascular disease studies in the United Kingdom have shown that the incidence of aortic dissection in the natural population is about 6/100,000 per year, more men than women, and the average age of onset is 63 years.
- the incidence of aortic dissection in China is much higher than that in Europe and the United States, and the age of onset is younger.
- Aortic disease may involve branch arteries, and once it involves a branch artery, it will be difficult to solve it by intervention.
- intra-arterial treatment has been carried out at home and abroad, that is, the minimally invasive method is used to treat the arterial disease and improve blood supply by inserting a graft into the diseased artery into the artery, thereby achieving therapeutic purposes.
- the arterial stent in the vascular lumen is composed of a tubular rigid wire stent and a polymer film fixed to the outside of the tubular rigid wire stent, and the tubular rigid wire stent is folded by a flexible rigid wire through a Z-shape.
- a stent graft Enclosed in a ring shape, and then a plurality of rings are stitched or bonded together with the polymer film to form a stent graft.
- the stent graft is axially compressed and loaded into the conveyor, and the conveyor passes through the smaller femoral artery.
- the radial artery and the radial artery are sent to the diseased artery and then released.
- the elastic force of the wire stent automatically returns to a straight tubular shape and is closely attached to the inner wall of the aorta, thereby isolating the arterial lesion from the blood flow, thereby achieving the therapeutic purpose.
- brackets commonly used in the treatment of arterial branching include a chimney bracket, an integrated multi-branch bracket, and a window-opening bracket. These brackets are limited by the structure of the bracket, and often require temporary customization, or are prone to problems such as endoleaks, such as There is a "groove" between the small stent and the main stent of the aorta, and there is a risk of endoleak. On the other hand, the main stent of the aorta is released in parallel with the small stent, and the main stent may compress the small stent, resulting in small stent blood flow. Poor, even blocked.
- the technical problem to be solved by the present invention is that, in view of the defects of the prior art, an aortic intraluminal shunt having a structure that is less prone to endoleaking, displacement, simplified surgical operation, reduced difficulty and risk of surgery, and wide adaptability is provided.
- An aortic intraluminal shunt comprising a tubular body support, the main body support comprising a tubular body cover, a main body support frame fixed on the wall surface of the main body cover, and the main body support is axially separated by a film
- a main cavity and at least one sub-cavity are separated, a main cavity cavity is disposed at a distal end of the main cavity, and a sub-chamber cavity is disposed at a distal end of the sub-chamber.
- At least a transverse end membrane is provided between the distal end of the main body membrane and the separation membrane, and the lateral end membrane covers and separates the main body. The membranes are joined together.
- the main cavity cavity, the sub-cavity cavity and the body coating end face are flush at least at the distal end;
- At least one of the main cavity and the sub-cavity mouth is higher or lower than the end surface of the main body film.
- At least one of the main cavity and the sub-cavity preferably has a cylindrical elongated film extending from the transverse end membrane in a distal direction.
- the extended coating end surface forms a main cavity, and the main cavity is higher than, lower than or flush with the end surface of the main body film;
- the extended film end face forms a sub-cavity port that is higher, lower or flush with the end surface of the body film.
- the inner wall or the outer wall of the extension film is provided with an extension support for supporting the extension film.
- the lateral end membrane is a planar structure perpendicular to a central axis of the main body bracket;
- transverse end coating is a bevel structure that is not perpendicular to the central axis of the main body bracket;
- the transverse end coating comprises at least one planar structure and at least one beveled structure, the planar structure and the beveled structure being integral to the unitary structure or joined together to form a unitary body.
- the main cavity is higher than the sub-cavity, and the lateral end membrane is a sloped structure, and the main cavity is inclined toward the sub-cavity.
- the inclined structure is inclined from a tangential line of the main cavity or an outer wall of the extended outer wall or a tangential direction to the sub-cavity; or the inclined structure is The intersection of the main cavity and the main body film is inclined toward the sub-cavity.
- a gap is left between the axial projections of the main cavity, the sub-chamber cavity and the main body bracket;
- At least two of the axial projections of the main cavity, the sub-chamber cavity and the main body bracket are arranged without a gap;
- the main cavity is composed of a side wall of the main body bracket and a transverse end film.
- the main cavity and the sub-cavity are respectively provided with development points for displaying the positions of the respective diverters of the diverter during surgery.
- the developing point is an annular developing support ring; or the developing points are spaced apart in a radial direction.
- the shunt of the invention can access the branch vessel from the distal sub-cavity without strictly controlling the axial position and the circumferential angle of the main body bracket, without worrying about the blood flow port and the human branch blood vessel port which are not accurately aligned with the side wall of the stent.
- the adverse consequences caused by the obstruction of the branch blood flow opening make the surgical procedure simple and the risk reduced.
- the sub-cavity mouth can be located on the transverse end membrane of the distal end of the main vessel stent, and the lateral end membrane can guide the traction guide wire when the branch vessel is connected, so that the traction guide wire can enter the sub-chamber more quickly, and the completion is completed. Positioning before branching of the vessel.
- the aortic shunt of the present invention is used to reconstruct an aortic branch of the aortic arch, which can resolve the aortic aneurysm of the aortic arch, the dissection of the aortic arch, and the aortic aneurysm of the visceral artery.
- the aorta shunt can be placed into the proximal end of the affected branch artery, for example, in the type A dissection or aortic arch aneurysm involving the superior branch of the bow, placed in the ascending aorta, and then through the carotid and femoral arteries, respectively.
- a connection channel with the aorta shunt is established, and the branch artery is reconstructed by bridging the main body stent by the branch vessel.
- the shunt can be placed in the descending aorta above the celiac artery, and the branching blood vessel is bridged with the superior mesenteric artery, the right renal artery, and the left renal artery. Thereby achieving reconstruction of important branches and isolation of aneurysms.
- the aortic shunt of the present invention has a wide range of applications, and at the same time, it can simplify the surgical operation and reduce the risk of surgery, and is particularly suitable for endovascular treatment of aortic dissection and/or aortic aneurysm involving important branches.
- 1a-1b are schematic views showing the structure of the aortic lumen shunt of the first embodiment
- FIG. 2a is a schematic structural view of the annular body support frame of Embodiment 1;
- 2b is a schematic view showing the connection of the annular body support frame and the main body film of the embodiment 1;
- 3-4c is a schematic structural view of a different embodiment of the distal end face structure of Embodiment 1;
- 5a-5b are schematic structural views of the aortic intraluminal shunt of Embodiment 2;
- Figure 6a is a schematic view showing the structure of the aortic lumen shunt of Embodiment 3;
- Figure 6b is a schematic view of another embodiment of Embodiment 3.
- Fig. 7 is a schematic structural view of Embodiment 4.
- the proximal end of the present invention refers to one end near the position of the heart, the distal end being one end away from the position of the heart.
- the height and the low in the present invention are relative to the main body film, and the end surface beyond the main body film is referred to as high, and the end surface not exceeding the end surface of the main body film is referred to as low, and the definition is merely for convenience of expression, and does not limit the flow.
- an aortic intraluminal shunt comprising a tubular body support 101 comprising a tubular body covering 120 and a body secured to the wall of the body covering 120
- the support frame 110, the inner cavity of the main body bracket 101 is axially separated by a partitioning membrane 131 to form a main cavity 140 and at least one sub-cavity 130, and the main cavity 140 is provided with a main cavity port 171 at the distal end thereof.
- the sub-cavity 130 is provided at the distal end of the sub-chamber 130.
- the main body bracket 101 is a main body structure of the intraluminal shunt, and includes a main body covering film 120 and a main body supporting frame 110.
- the main body covering film 120 has a tubular structure, and the transverse end surface has a circular or elliptical shape matching the blood vessel.
- the main body support frame 110 is sewed on the main body cover 120.
- the main body support frame 110 has a plurality of embodiments: the main body support frame 110.
- a plurality of annular wave support frames, the annular wave support frame may be a contour wave bracket, a high and low wave bracket, etc., and the structure for the film stent is applicable to the present invention. I will not repeat them here.
- the main body support frame 110 is composed of a plurality of Z-shaped or sinusoidal waves, and each Z-shaped or sinusoidal wave has one crest 111 and one adjacent trough 112, and the crest 111 There is a connecting rod 113 between the adjacent troughs 112.
- Each ring of the annular body support frame 110 is woven by a superelastic nickel-titanium wire, and the selectable wire diameter (ie diameter) of the superelastic nickel-titanium alloy wire ranges from 0.3 mm to 0.55 mm, and 0.5 mm is used in the first embodiment.
- Each annular body support frame 110 has a connecting steel sleeve 114. The two ends of the nickel-titanium wire are connected inside the steel sleeve 114, and then the two ends of the nickel-titanium wire are fixed to the steel by mechanical pressing or welding. Set of interiors.
- the second embodiment of the main body support frame 110 is a woven mesh structure or a cut mesh structure. This structure is also a common structure and will not be described here.
- the main body film 120 is made of polyester cloth or other polymer material, and the main body film 120 is straight in the axial direction.
- the main body support frame 110 is sewn on the main body film 120 by the suture 150, and the main body support frame 110 and the main body support frame 110 are The film 120 is connected by a stitching manner as shown in FIG. 2b.
- the stitching 150 follows the entire body support frame 110 along the waveform of the body support frame 110.
- the stitching 150 passes the main body support frame 110 through a plurality of non-equally spaced stitching knots. Stitched on the film 120, the diameter of the suture 150 is selected from 0.05 mm to 0.25 mm. In the present embodiment, the suture 150 has a diameter of 0.1 mm.
- the main body film 120 can also be made of polytetrafluoroethylene or other polymer materials, and the main body support frame 110 can be fixedly connected to the main body film 120 by hot pressing.
- the proximal or distal lumen of the body stent 101 is divided into a multi-chamber structure, that is, the lumen of the body stent 101 is axially separated by a separation membrane 131.
- the sub-cavity is independently formed by the separation film 131, and the cavity between the separation film 131 and the main body film is the main cavity 140.
- the diameter of the main cavity 140 is larger than the diameter of the sub-cavity 130, and the number of the sub-cavities 130 can be set according to actual needs, generally 1-4, preferably 2-4.
- the transverse end faces of the main cavity 140 and the sub-cavities 130 are circular, elliptical, fusiform or irregular curved. In this embodiment, a circular main cavity 140 and two circular sub-cavities 130 are provided.
- a film for connecting and closing the inner cavity is provided between the separation film 131 and the main body film 120. That is, at least between the distal end of the main body coating 120 and the partitioning film 131, a lateral end coating 180 is provided, which connects the main body coating 120 and the separation coating 131 together and closes the main body.
- the proximal or distal end of the stent has a gap between the main lumen 171 and the sub-chamber 172.
- the lateral end membrane 180 is disposed at least at the proximal or distal end of the body membrane 120, and may also be disposed at both the proximal end and the distal end of the body membrane 120.
- the lateral end film 180 is radially or substantially radially disposed with respect to the main body film 120 and the separation film 131.
- the lateral end coating 180 is a structure for lateral closure. There are various embodiments, and the first embodiment is that the horizontal end coating 180 is a planar structure perpendicular to the central axis of the main body support 101.
- the lateral end film 180 is located at the distal end of the main body film 120 and is sewn together with the main body film 120 by stitching.
- the main lumen 171 is an opening for attachment at the proximal or distal end of the main lumen 140, the diameter of which is less than the diameter of the body membrane, and is generally greater than the lumen diameter of the subchamber 130.
- the sub-cavity port 172 is disposed at the proximal end or the distal end of the sub-cavity 130.
- the diameter of the sub-cavity port 172 may be smaller than the diameter of the sub-cavity 130, or may be the same as the diameter of the sub-cavity 130. In this embodiment, the diameter of the sub-cavity port 172 is selected.
- the sub-cavities 130 are the same diameter.
- the main cavity port 171 is formed in such a manner as to be formed on the lateral end film 180.
- the main cavity 171 and the sub-cavity 172 are disposed on the lateral end film 180.
- the main cavity 171 and the sub-cavity 172 have different positional relationship with each other.
- the first embodiment is: the axial projection of the main cavity 171, the sub-cavity 172 and the main body bracket There is a gap between the two;
- the second embodiment is that at least two of the axial projections of the main cavity 171, the sub-chamber port 172 and the main body bracket are arranged without a gap;
- the main cavity port 171 is composed of the main body bracket side wall and the separation film 131 at the same time.
- the main cavity 171 and the sub-cavity 172 have different positional relationships in the radial direction.
- the main cavity 171 can be disposed at the radial center of the distal end of the stent, and As shown in FIG. 3-4a, the main cavity port 171 is disposed near the main body film 120, and the sub-chamber port 172 is distributed around the main cavity 171 or concentrated on the main cavity 171 side. As shown in FIG. 3 or 4a, the sub-chamber port 172 is disposed adjacent to the main cavity port 171. As shown in Figures 4b-4c, the sub-chamber cavity 172 is uniformly symmetrically disposed about the outside of the main cavity port 171.
- the main cavity 171 and the sub-cavity 172 have different embodiments.
- This embodiment is a first embodiment: the main cavity 171, the sub-cavity 172, and the end surface of the main body coating. At least at the distal end; that is, the length of the main body film 120 and the separation film 131 are the same in the axial direction, that is, the end surface of the separation film 131 is flush with the end surface of the main body film 120 at the proximal end or/and the distal end. .
- the main cavity 171 and the sub-cavity 172 are opened on the lateral end film 180.
- the main cavity 171 may be defined by suture stitching, or an annular support frame may be further provided, and the structure of the annular support frame may be adapted to the shape of the cavity, such as a circular shape, to prevent the main cavity 140 from being subjected to The sub-portion main cavity 171 is deformed after compression.
- the proximal and distal sub-chamber ports 172 of the sub-chamber 130 may also be sutured with sutures, or the sub-chamber ports 172 may be supported by annular supports, or annular and/or annular supports.
- the partitioning film 131 of the circumferential sub-cavity 130 extends from the distal end, that is, the sub-chamber cavity 172 to the proximal end to form a tubular structure, and the outer surface or the inner surface of the partitioning film 131 can be fixedly provided with a support frame, and the support frame is annular Support a stent graft or a woven mesh stent.
- the main cavity 171 and the sub-cavity 172 are respectively provided with development points 122 for displaying the positions of the respective orifices of the flow divider during surgery.
- the developing point 122 is selected from a developing material. It is specifically preferred that the development dot 122 is an annular development support ring; the support ring is preferably a superelastic material having developability. Alternatively, as shown in FIG. 1, the development dots 122 are spaced apart by a plurality of times in the radial direction.
- Embodiment 2 as shown in Fig. 5a, this embodiment is an improvement made on the basis of Embodiment 1. That is, the difference is that the lateral end coating 180 is a second embodiment: the transverse end coating 180 includes at least one planar structure 181 and at least one beveled structure 182, that is, the lateral end coating 180 is a planar structure 181 and a beveled structure 182. The combination. The combination is such that the planar structure 181 and the beveled structure 182 are integral with one another or joined together to form a unitary body. Due to the presence of the ramp structure 182, at least one of the main cavity 171 and the sub-chamber 172 is higher or lower than the end surface of the body film.
- the bevel structure 182 when the end surface of the main cavity 140 is higher than the end surface of the sub-cavity 130, the bevel structure 182 is inclined by the main cavity 140 toward the sub-cavity 130. That is, the main cavity port 171 is higher than the sub-cavity port 172, and the bevel structure 182 may be from the outer edge of the main cavity port 171 or the tangential line of the outer wall surface of the extended film or the tangential direction.
- the sub-cavity 130 is inclined in the direction; the bevel structure may also be inclined from the intersection of the main cavity 171 and the main body film toward the sub-cavity 130. As shown in Fig.
- the present embodiment is inclined from the tangent to the outer edge of the main cavity port 171 toward the sub-cavity 130.
- the length of the sub-cavity port 172 with respect to the concave axial direction of the main cavity port 171 is 5 mm, and the connecting sub-cavity 130 and the main cavity 140 and the main body film 120 are stitched inwardly with respect to the distal end of the main body bracket, which can further strengthen the branch. Stable stability after stent introduction.
- the film at the distal end of the main body film 120 corresponding to the position of the sub-cavity port 172 can be cut into two V-shaped or U-shaped shapes.
- the above structure can be adapted to the distal end of the main body bracket 101, and is also applicable to the proximal end of the main body bracket 101.
- the partitioning film 131 may be provided independently, or as shown in FIG. 5b, a support frame 132 may be fixed to the wall surface of the partitioning film 131.
- the structure of the support frame 132 may be a woven mesh support frame, or may be a plurality of annular wave support frames arranged in an axial direction.
- Embodiment 3 as shown in Figs. 6a-6b, this embodiment is an improvement made on the basis of Embodiment 2. That is, at least one of the main chamber 140 and the sub-chamber 130 extends from the lateral end membrane 180 in a distal direction with a cylindrical elongated coating 190.
- the elongated film 190 has an axial length of 5-10 mm.
- the extension film 190 may be formed by directly extending the separation film 131 in the distal direction, or may be formed to extend in the distal direction corresponding to the opening of the main cavity 140 provided on the lateral end film 180.
- the end surface of the elongated film 190 forms a main cavity 171 which is higher than, lower than or flush with the end surface of the main body film; the extended film end surface forms a sub-cavity port 172, the sub-cavity
- the cavity 172 is above, below or flush with the end surface of the body film.
- the other is to extend the distal opening of the membrane 190, i.e., the main lumen 171.
- the sub-lumen port 172 is an extended distal opening of the membrane.
- the main cavity 140 and the sub-cavity 130 are respectively provided with an extension film 190.
- the extension film 190 may be provided separately or as shown in FIG. 6b, and the inner wall or the outer wall of the extension film 190 is provided with an extension support frame 191 for supporting the extension film 190.
- the extension support frame 191 extends the support frame 191 into a wave support frame or a braid support frame.
- the extension film 190 can further improve the connection stability of the main cavity 140 and the branch stent.
- Embodiment 4 as shown in Fig. 7, this embodiment is an improvement made on the basis of Embodiment 2 or 3.
- the transverse end coating 180 is a third embodiment: the transverse end coating 180 is a bevel structure that is not perpendicular to the central axis of the main body bracket 101; the inclined surface structure is from the main cavity 171 and the main body coating 120 The intersection is inclined toward the sub-cavity.
- the main cavity is composed of the side wall of the main body bracket and the side of the transverse end film 180.
- the main cavity 171 is formed by the transverse end film 180 and the main body film 120.
- the structure is a fusiform shape. Or oblate, or semi-circular shapes.
- the bare body 121 may be disposed on the proximal end and the distal end of the main body film 120.
- the structure of the bare support 121 is a corrugated support frame and is fixed on the main body film 120 by stitching.
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- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
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Abstract
L'invention concerne un dispositif de dérivation endovasculaire aortique, comprenant un stent principal (101) tubulaire, le stent principal (101) comprenant une membrane principale (120) tubulaire, et un cadre de support principal (110) fixé sur une face de paroi de la membrane principale (120). L'intérieur du stent principal (101) est divisé axialement en une chambre principale (140) et au moins une sous-chambre (130) au moyen d'une membrane de séparation (131), une extrémité distale de la chambre principale (140) est pourvue d'une ouverture de chambre principale (171), et une extrémité distale de la sous-chambre (130) est pourvue d'une ouverture de sous-chambre (172). La structure du dispositif de dérivation ne provoque pas facilement une hémorragie interne ou un déplacement, peut simplifier les opérations chirurgicales et réduire la difficulté et le risque d'opération, et présente une large gamme d'applications.
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US11324583B1 (en) | 2021-07-06 | 2022-05-10 | Archo Medical LTDA | Multi-lumen stent-graft and related surgical methods |
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CN209661880U (zh) * | 2017-11-24 | 2019-11-22 | 杭州唯强医疗科技有限公司 | 主动脉腔内分流器 |
WO2020108546A1 (fr) * | 2018-11-28 | 2020-06-04 | 杭州唯强医疗科技有限公司 | Endoprothèse vasculaire présentant une performance de développement améliorée et endoprothèse ramifiée intégrée correspondante |
CN110638562A (zh) * | 2019-09-27 | 2020-01-03 | 上海长海医院 | 升主动脉及主动脉弓部变波幅预弯支架 |
WO2021223621A1 (fr) * | 2020-05-06 | 2021-11-11 | 杭州唯强医疗科技有限公司 | Endoprothèse vasculaire à flux divisé et endoprothèse vasculaire |
WO2022143097A1 (fr) * | 2020-12-31 | 2022-07-07 | 杭州唯强医疗科技有限公司 | Endoprothèse couverte |
CN116492108A (zh) * | 2023-03-01 | 2023-07-28 | 中国医学科学院阜外医院 | 分支动脉重建辅助装置及s-c分支优先主动脉重建系统 |
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