WO2019087888A1 - Composition, composition antimicrobienne, composition antivirale, composition anti-norovirus, pulvérisation et lingette - Google Patents

Composition, composition antimicrobienne, composition antivirale, composition anti-norovirus, pulvérisation et lingette Download PDF

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Publication number
WO2019087888A1
WO2019087888A1 PCT/JP2018/039452 JP2018039452W WO2019087888A1 WO 2019087888 A1 WO2019087888 A1 WO 2019087888A1 JP 2018039452 W JP2018039452 W JP 2018039452W WO 2019087888 A1 WO2019087888 A1 WO 2019087888A1
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group
composition
compound
formula
substituent
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PCT/JP2018/039452
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English (en)
Japanese (ja)
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知昭 吉岡
寛記 杉浦
尚俊 佐藤
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富士フイルム株式会社
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Priority to JP2019551188A priority Critical patent/JPWO2019087888A1/ja
Publication of WO2019087888A1 publication Critical patent/WO2019087888A1/fr

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A01N25/06—Aerosols
    • A—HUMAN NECESSITIES
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    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
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Definitions

  • the present invention relates to a composition, an antibacterial composition, an antiviral composition, an anti-norovirus composition, a spray and a wiper.
  • Viruses unlike bacteria having a cell structure and microorganisms such as fungi, have no cell structure and are a structure having a genome in a coat protein called capsid. Viruses are roughly divided into two types depending on whether the genome is DNA (deoxyribonucleic acid) or RNA (ribonucleic acid), and the enveloped virus is composed of an envelope consisting of a lipid bilayer and a capsid consisting of a lipid bilayer membrane, and the non-enveloped case. It is further classified according to whether it is a membrane virus.
  • DNA-type filmed viruses include human herpesvirus and hepatitis B virus, DNA-type non-film viruses such as adenovirus and B19 virus, and RNA-type filmed viruses such as influenza Viruses, RNAS type non-membrane viruses such as SARS (severe acute respiratory syndrome) coronavirus, norovirus, polio virus, enterovirus etc. are included.
  • SARS severe acute respiratory syndrome
  • Patent Document 1 discloses an anti-norovirus composition containing grapefruit seed extract (claim 2).
  • the present inventors examined the anti-norovirus composition described in Patent Document 1 and found that there is room for improvement in antiviral activity.
  • this invention makes it a subject to provide the composition which is excellent in antiviral activity.
  • Another object of the present invention is to provide an antimicrobial composition, an antiviral composition, an anti-norovirus composition, a spray, and a wiper, using the above composition.
  • the total content of one or more compounds selected from the group consisting of the compound A, the compound B, the compound C, and the compound D in the composition is the total mass of the composition.
  • An antimicrobial composition comprising the composition according to any one of [1] to [12].
  • An antiviral composition comprising the composition according to any one of [1] to [13].
  • An anti-norovirus composition comprising the composition according to any one of [1] to [14].
  • a spray comprising: a spray container; and the composition according to any one of [1] to [12] contained in the spray container.
  • a wiper comprising: a base fabric; and the composition according to any one of [1] to [12] impregnated in the base fabric.
  • a composition having excellent antiviral activity can be provided. Further, according to the present invention, an antimicrobial composition, an antiviral composition, an anti-norovirus composition, a spray and a wiper can be provided using the above composition.
  • a numerical range represented using “to” means a range including numerical values described before and after “to” as the lower limit value and the upper limit value.
  • (meth) acrylate is a concept including either or both of acrylate and methacrylate.
  • substituents etc. when there are a plurality of substituents and linking groups etc. (hereinafter referred to as substituents etc.) represented by specific symbols, or when a plurality of substituents etc.
  • each substituent is It means that they may be the same as or different from each other. The same applies to the definition of the number of substituents and the like.
  • the notations not describing substitution and non-substitution include those having no substituent and those having a substituent.
  • the "alkyl group” includes not only an alkyl group having no substituent (unsubstituted alkyl group) but also an alkyl group having a substituent (substituted alkyl group).
  • composition of the present invention is one or more compounds selected from the group consisting of Compound A, Compound B, Compound C, and Compound D described below (hereinafter collectively referred to as “specific compounds”. Also referred to), as well as solvents comprising at least an alcohol.
  • specific compounds Compound A
  • specific compounds Compound B
  • solvents comprising at least an alcohol.
  • the content of the alcohol in the composition is 40 to 100% by volume based on the total volume of the solvent, and the pH of the composition is more than 9.5 and 14.0 or less.
  • the specific compound which is a kind of polyphenol is a phenoxide anion in which the phenolic hydroxyl group is dissociated in the pH range of more than 9.5, It is speculated that this will inactivate the virus.
  • non-natural products other than extracts from natural products such as plants can also be used. Natural products such as extracts from natural products such as plants are generally prone to variations in performance from production lot to production lot. Since the composition of the present invention can also use non-natural products, it has the advantage of facilitating control of performance variation among production lots.
  • the composition of the present invention contains a specific compound.
  • the specific compound is a generic name of compound A, compound B, compound C and compound D.
  • the content of the specific compound in the composition of the present invention (the total amount of multiple specific compounds, if any) is 0. 0 to the total mass of the composition. It is generally 01 to 10.00% by mass, preferably 0.02 to 5.00% by mass, more preferably 0.05 to 5.00% by mass, still more preferably 0.10 to 5.00% by mass. 0.30 to 5.00% by mass is particularly preferred, and 0.40 to 5.00% by mass is most preferred.
  • the compound A, the compound B, the compound C, and the compound D will be individually described below.
  • Compound A has two residues (hereinafter also referred to as “residues of formula (1)”) obtained by removing one or more hydrogen atoms other than hydrogen atoms in a hydroxyl group in a compound represented by the following formula (1) It is a compound possessed above.
  • a plurality of residues of formula (1) may be directly bonded to each other, or a plurality of residues of formula (1) may be bonded via a linking group.
  • Two or more residues of the formula (1) contained in the compound A may be identical to or different from each other.
  • the molecular weight of the compound A is, for example, preferably 218 to 2000, and more preferably 218 to 1500.
  • the number of residues of the formula (1) possessed by the compound A is, for example, preferably 2 to 10, and more preferably 1 to 6.
  • the compound A may be a polymer.
  • Compound A, which is a polymer preferably has a repeating unit containing a residue of formula (1).
  • the weight average molecular weight of Compound A, which is a polymer is, for example, preferably 1,000 to 1,000,000, and more preferably 5,000 to 1,000,000.
  • a weight average molecular weight (Mw) is defined as a polystyrene conversion value by GPC (Gel Permeation Chromatography).
  • X 11 to X 14 each independently represent a nitrogen atom or —CR 11 ⁇ .
  • R 11 represents a hydrogen atom or a substituent.
  • each R 11 may be the same as or different from each other.
  • R 11 for example, a hydroxyl group, an alkyl group, an aryl group, a heterocyclic group (a non-aromatic heterocyclic ring, an aromatic heterocyclic ring, etc.
  • Hetero atom is a nitrogen atom, a sulfur atom, or an oxygen atom
  • R S1 represents an alkyl group. If R S1 in one group there is a plurality, the plurality of R S1 may be different may be respectively identical. Moreover, the substituent may further have a substituent, if possible.
  • the alkyl group may be linear or branched, and may have a cyclic structure.
  • the carbon number is preferably 1 to 20.
  • the aryl group preferably has 6 to 15 carbon atoms, and more preferably 6 carbon atoms.
  • R 11 is preferably, for example, a hydrogen atom or a substituent having a Hammett substituent constant ⁇ p of more than 0.
  • Hammett substituent constant ⁇ p is determined according to Chem. Rev. 1991, 91, p 165-195 can be referred to.
  • R T1 and R T2 each independently represent a hydrogen atom or a substituent (for example, an alkyl group (which may be linear or branched or may have a cyclic structure). Or a group having an ester group (eg, an ester group, an alkyl group which may have a substituent, and a substituent of the alkyl group is preferably a hydroxyl group and / or a carboxy group) Represents R T1 and R T2 may be bonded to each other to form a ring.
  • a substituent for example, an alkyl group (which may be linear or branched or may have a cyclic structure).
  • a group having an ester group eg, an ester group, an alkyl group which may have a substituent, and a substituent of the alkyl group is preferably a hydroxyl group and / or a carboxy group
  • a hydrocarbon having 10 or more carbon atoms (preferably 12 or more carbon atoms) among the substituent T groups preferably a group containing a group R T1 is 10 or more carbon atoms (preferably having 12 or more carbon atoms) of -CO-O-R T11 containing hydrocarbon group, R T1 is 10 or more carbon atoms (preferably 12 or more carbon atoms -CO-NH-R T1 containing a hydrocarbon group), or R T1 and R T2 is and comprises both a hydrocarbon group having a total carbon number of R T1 and R T2 is 10 or more (preferably having 12 or more total carbon And —CO—N (R T1 ) (R T2 ) is more preferable.
  • hydrocarbon group examples include aliphatic hydrocarbon groups, and specific examples include linear, branched or cyclic alkyl, alkenyl, or alkynyl groups.
  • the upper limit of the carbon number of the hydrocarbon group is not particularly limited, and is, for example, 30 or less.
  • the ClogP value of the hydrocarbon group is not particularly limited, but is, for example, 1.00 or more, preferably 5.00 or more, and more preferably 7.00 or more. In addition, the upper limit in particular is not restrict
  • the ClogP value of the above-mentioned hydrocarbon group can be determined by ChemBioDraw Ultra Ver13.
  • compound A preferably has at least one residue of formula (1) having R 11 which is any of the substituent T group, and more preferably has two or more. It is further preferred that all residues of formula (1) in compound A be residues of the compound of formula (1) having R 11 which is any of the substituent T group.
  • each of a plurality of R 11 is an alkenyl group (for example, a vinyl group)
  • a benzene ring can be formed.
  • R ⁇ 11 >'s are all alkyl groups, if the terminal carbon atom in each alkyl group mutually couple
  • the ring formed by bonding a plurality of R 11 to each other may be an aromatic ring (for example, an aromatic hydrocarbon ring and an aromatic heterocycle), and a nonaromatic ring (for example, a nonaromatic hydrocarbon ring and a nonaromatic ring) It may be an aromatic heterocycle.
  • the ring formed may have a condensed ring structure in which the ring is further condensed.
  • the ring to be formed is preferably a 5- or 6-membered monocyclic ring or a polycyclic ring which is a combination thereof, and when each ring is a heterocyclic ring, the number of heteroatoms is preferably 1 to 5.
  • a nitrogen atom, a sulfur atom, an oxygen atom, a selenium atom, a tellurium atom, a phosphorus atom, a silicon atom, and a boron atom are mentioned, for example.
  • nitrogen atom, sulfur atom or oxygen atom is preferable.
  • the ring formed is, for example, benzene ring, naphthalene ring, chroman ring, quinoline ring, quinoxaline ring, coumarin ring, anthraquinone ring, 3-cyclobutene-1,2-dione ring, dihydrofuran ring, crotonolactone ring, A cyclopentene-1,2,3-trione ring, a 2,4,6-cycloheptatrien-1-one ring, and a benzoquinone ring.
  • Such a ring further has one hydrogen atom from the hydroxyl group of a substituent (alkyl group, hydroxyl group, cyano group, carboxyl group, sulfonic acid group, alkyl ester alkylene group, and saccharide (for example, disaccharide such as rutinose) Remaining residues, etc.
  • substituent alkyl group, hydroxyl group, cyano group, carboxyl group, sulfonic acid group, alkyl ester alkylene group, and saccharide (for example, disaccharide such as rutinose) Remaining residues, etc.
  • Compound A when having in the compound represented by the formula (1), a hydrogen atom other than a hydrogen atom one or more except residues in the hydroxyl group (formula (1) residue), X 11 ⁇
  • the position at which the hydrogen atom to be removed in R 11 was present is the bonding position of the residue of the formula (1) with another group. Note that when R 11 to be removed a hydrogen atom is a hydrogen atom, R 11 itself is removed.
  • R 11 from which a hydrogen atom is removed is preferably any one of the groups having a hydrogen atom in the above-mentioned substituent group T, or a hydrogen atom, and —CO—O—R T1 or —O—CO—R T1 (wherein In these cases, R T1 is more preferably a hydrogen atom or a substituent having a hydrogen atom.
  • R 1-2 is a hydrogen atom, a hydroxyl group, or an alkoxy group (which may be linear or branched, and may have a cyclic structure. Carbon number is 10 to 20) Is preferable).
  • m 1-2 represents an integer of 1 to 3 and is preferably 1. * Represents a bonding position.
  • R 1-2a and R 1-2b have the same meanings as R 1-2 in formula (1-2).
  • R 1-2a and R 1-2b may be identical to or different from each other.
  • L 1-2a and L 1-2b each independently represent a single bond or a divalent linking group.
  • Examples of the divalent linking group include an ether group, a carbonyl group, an ester group, a thioester group, an amido group, a sulfonamide group, a thioether group, -SO 2- , -NR A- (R A represents a hydrogen atom or an alkyl Group, an aryl group or a heteroaryl group), a divalent hydrocarbon group (for example, an alkylene group, an alkenylene group, an alkynylene group and an arylene group), a heteroarylene group, an azo group, and the like A combined group is mentioned.
  • Each of L 1-2a and L 1-2b is preferably a group consisting of a single bond, an ester group, a vinylene group, or a combination thereof (eg, -vinylene group-ester group-).
  • l 1-3 represents 0 or 1;
  • m 1-3 represents an integer of 2 or more.
  • m 1 -3 is preferably 2 to 10, and more preferably 2 to 6.
  • X 1-3 when m 1-3 is 2, it represents a single bond or a divalent linking group, when m 1-3 is greater than 2, representing the m 1-3 divalent linking group.
  • a plurality of groups other than X 1-3 are present respectively, and each group represented by the same symbol may be the same or different.
  • X 1-3 is preferably a single bond or a divalent linking group represented by the following formula.
  • Rx 2 represents a hydrogen atom, a halogen atom, or an alkyl group (a straight-chained, may be a branched chain, preferably also be. 1 to 20 carbon atoms which have a cyclic structure).
  • Ar represents an arylene group (preferably having a carbon number of 1 to 20, a phenylene group, a naphthylene group, an anthracenylene group is preferable, and an anthracenylene group is more preferable).
  • * represents a bonding position with L 1-2a or L 1-2b .
  • X 1-3 is preferably any of the trivalent linking groups represented by the following formulae.
  • Rx 3 is a hydrogen atom, a halogen atom, or an alkyl group (which may be linear, branched, or cyclic, and preferably has 1 to 20 carbon atoms, and a methyl group is more preferable Preferably).
  • * Represents a bonding position with L 1-2a or L 1-2b .
  • X 1-3 is preferably a tetravalent linking group represented by the following formula. * Represents a bonding position with L 1-2a or L 1-2b .
  • X 1-3 is preferably a pentavalent linking group represented by the following formula. * Represents a bonding position with L 1-2a or L 1-2b .
  • X 1-3 is preferably a hexavalent linking group represented by the following formula. * Represents a bonding position with L 1-2a or L 1-2b .
  • a linear or branched carbon number of 10 or more is preferable.
  • a group containing a hydrocarbon group of several 12 or more) is preferable, and a group containing a branched hydrocarbon group having 10 or more (preferably 12 or more carbon) carbon atoms is more preferable.
  • the upper limit of the carbon number of the hydrocarbon group is not particularly limited, and is, for example, 30 or less.
  • a group containing a linear or branched C10 or more (preferably 12 or more carbon) hydrocarbon group for example, an ether group, a carbonyl group, an ester group, a thioester group, an amide group, a sulfonamide group , A thioether group, -SO 2- , -NR A- (where R A represents a hydrogen atom, an alkyl group, an aryl group or a heteroaryl group), a heteroarylene group, and an azo group
  • R A represents a hydrogen atom, an alkyl group, an aryl group or a heteroaryl group
  • a heteroarylene group a heteroarylene group
  • azo group examples thereof include linear or branched alkyl groups having 10 or more carbon atoms (preferably 12 or more carbon atoms), alkenylene groups, and alkynylene groups, which may contain a divalent linking group.
  • the ClogP value of the hydrocarbon group is not particularly limited, but is, for example, 1.00 or more, preferably 5.00 or more, and more preferably 7.00 or more.
  • the upper limit in particular is not restrict
  • the ClogP value of the above-mentioned hydrocarbon group can be determined by ChemBioDraw Ultra Ver13.
  • the compound A when the compound A is a polymer and has a repeating unit containing a residue of the formula (1), the compound A preferably has a repeating unit represented by the following formula.
  • the polymer may have repeating units other than the repeating unit represented by the following formula.
  • R xma is a hydrogen atom, a halogen atom, or an alkyl group (which may be linear or branched, or may have a cyclic structure.
  • the carbon number is preferably 1 to 20, and a methyl group is more preferable.
  • a perfluoroalkyl group (which may be linear, branched or have a cyclic structure, preferably has 1 to 20 carbon atoms, and more preferably a trifluoromethyl group).
  • Lx represents a single bond or a divalent linking group.
  • the definition of the divalent linking group is the same as the definition of the divalent linking group represented by L 1-2 .
  • X represents a residue of formula (1).
  • the compound B is a compound represented by the following formula (2).
  • the compound B is a compound other than the compound A. Specifically, the compound B does not include a form having two or more residues of the formula (1).
  • the molecular weight of the compound B is preferably 110 to 2,000, and more preferably 120 to 1,500.
  • R 21 in —CR 21 ⁇ ⁇ represents a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a nitro group or a group represented by the formula (5).
  • each R 21 may be the same as or different from each other.
  • L 2 is an arylene group which may have a substituent, a heteroarylene group which may have a substituent, or any of the following formulas (6) to (9) Represents a divalent linking group represented.
  • R 2x represents a hydrogen atom or a substituent. * Represents a bonding position.
  • R 2a is an alkyl group which may have a substituent (which may be linear or branched, and may have a cyclic structure. The number of carbon atoms is 1 to 20 are preferable) or a hydrogen atom.
  • R 2b to R 2d independently represents a hydrogen atom or a substituent. * 1 is the same as * in formula (5). * 2 represents the bonding position with R 2x .
  • Each of R 2e to R 2k independently represents a hydrogen atom or a substituent.
  • R 2x and R 2e to R 2k examples include the groups listed in the description of the substituent represented by R 11 described above.
  • R 2x and R 2b to R 2k for example, hydrogen atom, halogen atom, hydroxyl group, cyano group, carboxyl group, nitro group, alkyl group, alkenyl group, alkynyl group, alkoxy group, alkylamino group, aryl group , Arylamido group, nitroarylene group, alkyl ester group, amino alkylene group, alkylamino alkylene group, alkali metal oxy group (-ONa and OK, etc.), and a combination thereof (eg, alkyl group portion with hydroxyl group, And alkyl ester groups having a carboxyl group).
  • the group represented by Formula (5) may connect with each other in the group to form a ring.
  • the direct bond to the vinylene group to which R 2a is bonded in the formula is a methylene group which may have a substituent (Ie, the atom closest to the vinylene group in R 2a is a carbon atom having no unsaturated bond).
  • the ring formed may be an aromatic ring (for example, an aromatic hydrocarbon ring and an aromatic heterocycle) or a non-aromatic ring (for example, a nonaromatic hydrocarbon ring and a nonaromatic heterocycle).
  • the ring formed may have a condensed ring structure in which the ring is further condensed.
  • the ring to be formed is preferably a 5- or 6-membered monocyclic ring or a polycyclic ring which is a combination thereof, and when each ring is a heterocyclic ring, the number of heteroatoms is preferably 1 to 5.
  • a hetero atom of the said heterocyclic ring a nitrogen atom, a sulfur atom, or an oxygen atom is preferable.
  • a chromanone ring etc. are mentioned, for example.
  • bonds together, and forms a ring is the same as the aspect which several R ⁇ 11 > mutually couple
  • the condensed ring structure may be a structure in which an aromatic ring or a non-aromatic ring is condensed to a ring having a hydroxyl group arranged adjacent to each other in Formula (2).
  • Examples of the ring to be fused include the rings described above as the ring formed by combining R 11 with each other.
  • R 21 is preferably, for example, a hydrogen atom or a substituent having a Hammett substituent constant ⁇ p of more than 0. Further, R 21 is preferably a hydrogen atom or any of the above-mentioned substituent T groups.
  • the compound B preferably has at least one R 21 which is any of the above-mentioned substituent T groups.
  • a compound represented by the following formula (2-2) or a compound represented by the formula (2-3) is preferable.
  • Rx 2-2 represents a hydrogen atom or a hydroxyl group.
  • R 2-2 has the same meaning as R 21 described above.
  • R 2-2 is preferably a group having a vinylene group or any of a substituent group T, and -CO-RT 1 , -CO-O-RT 1 or -CO-NH-RT 1 is more preferable.
  • the carbon number in the substituent T group is 10 or more (preferably carbon A group containing a hydrocarbon group of several 12 or more) is preferable, and R T1 is a carbon number of 10 or more (preferably, a carbon number of 12 or more) containing —CO—O—R T11 , R T1 is 10 or more carbon atoms
  • R T1 is 10 or more carbon atoms
  • R 2-3a and R 2-3b independently has the same meaning as R 21 described above.
  • R 2-3a and R 2-3b are each independently preferably one of the substituents T group, -CO-R T1, -CO- O-R T1, or, -CO-NH-R T1 Gayori preferable.
  • R 2-3a and R 2-3b as described above, from the viewpoint of obtaining excellent antiviral property by further raising the ClogP value of the specific compound, each of them is independently selected from the substituent T group.
  • R T1 is a hydrocarbon group containing 10 or more carbon atoms (preferably 12 or more carbon atoms).
  • T11, R T1 is 10 or more carbon atoms and (preferably having 12 or more carbon atoms) a -CO-NH-R T1
  • R T1 and R T2 is a hydrocarbon group containing a hydrocarbon group R T1 and R More preferred is —CO—N (R T1 ) (R T2 ) in which the total carbon number of T2 is 10 or more (preferably 12 or more in total carbon number).
  • R 2-3a and R 2-3b may be bonded to each other to form a ring.
  • a ring formed by bonding a plurality of R 11 to each other is similarly mentioned, and a benzene ring is preferable.
  • the compound C is a compound represented by the following formula (3).
  • the compound C is a compound other than the compound A and the compound B.
  • the molecular weight of the compound C is, for example, preferably 110 to 2,000, and more preferably 120 to 1,500.
  • X 31 to X 34 each independently represent a nitrogen atom or —CR 31 ⁇ .
  • R 31 represents a substituent other than a hydroxyl group or a hydrogen atom.
  • R 31 a hydroxyl group is excluded.
  • the substituent represented by R 31 is, forms having a hydroxyl group as substituent (e.g., hydroxyalkyl groups) are not excluded.
  • Examples of the substituent represented by R 31 include the groups described for the substituent represented by R 11 in Formula (1) other than the above-mentioned hydroxyl group.
  • the plurality of R 31 s may be bonded to each other to form a ring.
  • the aspect mentioned above as an aspect which R ⁇ 11 > mutually joins and forms a ring is mentioned.
  • R 31 is preferably, for example, a hydrogen atom or a substituent having a Hammett substituent constant ⁇ p of more than 0. Further, R 31 is preferably a hydrogen atom or any of the above-mentioned substituent T groups.
  • the compound C preferably has at least one R 31 which is any of the above-mentioned substituent T groups.
  • R 3-2 has the same meaning as R 31 described above.
  • R 3-2 is preferably any one of a substituent group T, and more preferably -CO-RT 1 , -CO-O-RT 1 , or -CO-NH-RT 1 .
  • the carbon number in the substituent T group is 10 or more (preferably carbon A group containing a hydrocarbon group of several 12 or more) is preferable, and R T1 is a carbon number of 10 or more (preferably, a carbon number of 12 or more) containing —CO—O—R T11 , R T1 is 10 or more carbon atoms
  • R T1 is 10 or more carbon atoms
  • the compound D is a compound represented by the following formula (4). Further, the compound D is a compound other than the compounds A to C.
  • the molecular weight of the compound D is, for example, preferably 110 to 2,000, and more preferably 120 to 1,500.
  • R 41 represents a hydrogen atom or a substituent.
  • Two —CR 41 s are present, and two —CR 41 s may be the same or different.
  • At least one of two R 41 represents a substituent.
  • Examples of the substituent represented by R 41 include the groups described as the substituent represented by R 11 in Formula (1).
  • Two —CR 41 ⁇ may combine with each other to form a ring. That is, when X 41 and X 42 are —CR 41 2, two adjacent R 41 's may combine with each other to form a ring.
  • the ring formed includes the vinylene group in formula (4), but the ring formed is limited to non-aromatic rings. In the case where a ring in which the ring is condensed is further present in the ring to be formed (the ring containing a vinylene group), the ring in which the ring is condensed may be an aromatic ring.
  • the embodiment in which two adjacent R 41 's are bonded to each other to form a ring is not particularly limited.
  • a carbon atom in a substituent represented as two adjacent R 41 a nitrogen atom, oxygen
  • an atom and an atom selected from a sulfur atom bond to each other to form a ring.
  • two adjacent R 41 's are both alkyl groups
  • terminal carbon atoms in the respective alkyl groups can bond to each other to form an aliphatic hydrocarbon ring.
  • R 41 is preferably, for example, a hydrogen atom or a substituent having a Hammett substituent constant ⁇ p of more than 0. Further, R 41 is preferably a hydrogen atom or any of the above-mentioned substituent T groups.
  • the compound D preferably has at least one R 41 which is any of the above-mentioned substituent T groups.
  • the compound D is preferably a compound represented by the formula (4-2).
  • a 4-2 represents an alkylene group which forms a non-aromatic ring by binding to the vinylene group in the formula at both ends to form an alkylene group, and one or more methylene groups in the alkylene group are It may be substituted by an ether group, a carbonyl group, an ester group or a thioether group.
  • the carbon number of the alkylene group is preferably 2 to 4.
  • one methylene group is preferably substituted by an ether group.
  • the number of members of the nonaromatic ring is preferably 4 to 6.
  • R 4-2 is a hydrogen atom or a substituent and has the same meaning as R 41 described above.
  • R 4-2 is preferably, for example, any of substituent group T or an alkyl group (preferably, an alkyl group substituted with two hydroxyl groups).
  • the ClogP value of the specific compound contained in the composition of the present invention is, for example, 0.0700 or more, and 5.00 or more is preferable in that the antiviral activity is more excellent. Further, the upper limit thereof is not particularly limited, but is, for example, 20.00 or less, preferably 15.00 or less. Among them, the ClogP value of the specific compound is preferably 5.00 to 20.00, and more preferably 7.00 to 15.00, in that the antiviral activity is more excellent.
  • Viruses generally have hydrophilic and hydrophobic sites. For this reason, when the specific compound is more hydrophobic (in other words, when the ClogP value of the specific compound is 5.00 or more), the specific compound is considered to be easily adsorbed by the virus. As a result, the specific compound is more excellent in antiviral activity.
  • the ClogP of a specific compound can be determined by ChemBioDraw Ultra Ver13.
  • the alcohol is not particularly limited.
  • linear, branched and cyclic alcohols having 1 to 20 carbon atoms are preferable.
  • the above-mentioned alcohol is preferably a food additive from the viewpoint of safety, among which methanol, ethanol, propanol, isopropanol, polyethylene glycol, propylene glycol, propylene glycol acetic acid monoester, n-butanol, 2-butanol, butane -1,3-diol, diethylene glycol, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, dipropylene glycol, 2-methyl-1-butanol, 1-decanol, 1-penten-3-ol, 2-ethyl 1-hexanol, 2-Pentanol, 3-pentanol, 3-methyl-2-butanol, 3-methyl-2-butenol, 3-methyl-3-butanol, isoamyl alcohol, i-butanol, benzene Benzyl alcohol, citronellol, terpineol, hydroxy citronellal, or hydroxy cit
  • the composition of the present invention preferably contains, as the alcohol, an alcohol having 2 or less carbon atoms and an alcohol having 3 or more carbon atoms as the variation of the antiviral activity value is further reduced.
  • Alcohols having 3 or more carbon atoms are considered to be more fat-soluble than alcohols having 2 or less carbon atoms, and to be capable of physically removing viruses and latent stains on which they reside. For this reason, when a composition in which a composition contains an alcohol having 2 or less carbon atoms and an alcohol having 3 or more carbon atoms is impregnated in a wiper and used for wiping, it is considered that the variation of the antiviral activity value becomes smaller.
  • the volume ratio of the alcohol having 3 or more carbon atoms to the alcohol having 2 or less carbon atoms is preferably 0.01 or more in that the antiviral activity is more excellent and / or the variation of the antiviral activity is smaller.
  • the upper limit thereof is not particularly limited, but is, for example, 5 or less, preferably 1.5 or less.
  • the composition of the present invention may contain a solvent other than alcohol.
  • solvents other than alcohol water or organic solvents (except alcohol) can be mentioned.
  • the organic solvent is not particularly limited. For example, acetone, methyl ethyl ketone, cyclohexane, ethyl acetate, isoamyl acetate, isopropyl acetate, geranyl acetate, cyclohexyl acetate, citronellyl acetate, cinnamyl acetate, terpinyl acetate, phenylethyl acetate, butyl acetate, acetic acid Benzyl, menthyl acetate, linalyl acetate, butyric acid, ethyl butyrate, butyl butyrate, isoamyl butyrate, cyclohexyl butyrate, ethylene dichloride, tetrahydrofuran, tolu
  • the organic solvent is preferably a food additive from the viewpoint of safety, and is acetone, methyl ethyl ketone, ethyl acetate, isoamyl acetate, isopropyl acetate, geranyl acetate, cyclohexyl acetate, citronellyl acetate, cinnamyl acetate, terpinyl acetate, phenyl acetate Ethyl, butyl acetate, benzyl acetate, menthyl acetate, linalyl acetate, butyric acid, ethyl butyrate, butyl butyrate, isoamyl butyrate, cyclohexyl butyrate, 2-methylpropanal, 2-methylbutyraldehyde, 3-methyl-2-butenal 3-methyl Butanal, l-perylaldehyde, acetaldehyde, ethyl acetoacetate, isoamy
  • the content of the solvent (the total amount of multiple solvents, if any) is preferably 0.5 to 99.9% by mass, and 10 to 99.8% by mass with respect to the total mass of the composition. % Is more preferable, 50 to 99.8% by mass is more preferable, and 80 to 99.8% by mass is particularly preferable.
  • the content of alcohol (the total of two or more species, if any) is 40 to 100% by volume with respect to the total volume of the solvent in that it is more excellent in antiviral activity, 45 to 100 % By volume is preferable, and 50 to 100% by volume is more preferable.
  • the composition of the present invention has a pH of more than 9.5 and 14.0 or less.
  • the antiviral activity may be inferior.
  • the pH is preferably 10.0 or more, and more preferably 10.5 or more in that the antiviral activity is more excellent.
  • pH is 14.0 or less, and 12.0 or less is preferable at the point which can suppress corrosion with respect to a metal more. That is, the pH of the composition is preferably 10.0 to 12.0, and more preferably 10.5 to 12.0.
  • the pH can be measured using a bench-top pH meter "F-72S” (manufactured by Horiba, Ltd.) using a pH electrode "6337-10D” (manufactured by Horiba, Ltd.). The specific measurement method is as described later.
  • pH intends the value in 25 degreeC.
  • composition of the present invention may contain components other than the above as long as the effects of the present invention are exhibited.
  • the optional components are not particularly limited, but, for example, bactericidal agents, disinfectants, disinfectants, surfactants, antioxidants, pH adjusters, ultraviolet absorbers, chelating agents, moisturizers, thickeners / gelling agents And preservatives, perfumes, and pigments.
  • the composition of the present invention preferably contains a bactericidal agent, a disinfectant, a disinfectant, a surfactant, or an antioxidant, among others, from the viewpoint of being more excellent in antiviral activity, and a phenol compound other than the specific compound More preferably, it contains a quaternary ammonium salt (eg, benzalkonium chloride etc.), a surfactant, or an antioxidant.
  • a bactericidal agent e.g, benzalkonium chloride etc.
  • the disinfectant, disinfectant, and disinfectant are not particularly limited, and examples thereof include phenolic compounds other than specific compounds, quaternary ammonium salts, antibacterial agents containing metals, photocatalysts, aldehyde compounds, iodo compounds, and piguanides. Examples thereof include compounds and acrinol hydrate (lactic acid 6,9-diamino-2-ethoxyacridine monohydrate). Among them, phenolic compounds other than the specific compounds or quaternary ammonium salts are preferable in that they are more excellent in antiviral activity when combined with the composition of the present invention in that they are more excellent in antiviral activity.
  • Phenolic compounds other than specific compounds have, for example, an aromatic hydrocarbon ring having 6 to 16 carbon atoms (for example, a benzene ring, a naphthalene ring, a phenanthrene ring, an anthracene ring, and a pyrene ring) having one hydroxyl-substituted group.
  • aromatic hydrocarbon ring having 6 to 16 carbon atoms for example, a benzene ring, a naphthalene ring, a phenanthrene ring, an anthracene ring, and a pyrene ring
  • aromatic hydrocarbon group and aromatic heterocycle may be fused (for example, indole ring, quinoline ring, acridine ring, etc.).
  • phenolic compounds those used as food additives are preferable from the viewpoint of safety.
  • p-oxybenzoic acid esters methyl, ethyl, propyl, butyl, isopropyl and isobutyl esters
  • 4-allyl-2,6-dimethoxyphenol 4-allylphenol, carvacrol, creosol, 3-methyl Phenol, 2-methylphenol, 4-methylphenol, 2-methoxy-4-propylphenol, 2,6-dimethoxyphenol, 2,3-dimethylphenol, 2,6-dimethylphenol, 3,5-dimethylphenol, 4 -Ethoxyphenol, 4-ethyl-2-methoxyphenol, 4-ethyl-2-methoxyphenol, 2-ethylphenol, 3-ethylphenol, 4-ethylphenol, ethyl vanillin propylene glycol acetal (ethylvanillin p opylene glycol acetal), guaiacol, 4-hydroxybenzoic acid,
  • Citrasled No. 1 2 Sudan G, Scarlet GN, Food Yellow No. 4, Food Red No. 102, Bonso 2R, Bonso 6 R, Food Green No. 3, Red 10 B, Food Red No. 2, Food Red No. 40, Hesperidin, Methyl Hesperidin, Folic Acid, Or salicylic acid is preferred, P-hydroxybenzoic acid esters (methyl, ethyl, propyl, butyl, isopropyl and isobutyl esters), 4-allyl-2,6-dimethoxyphenol, 4-allylphenol, carvacrol, creosol, 3-methylphenol, 2-methyl Phenol, 4-methylphenol, 2-methoxy-4-propylphenol, 2,6-dimethoxyphenol, 2,3-dimethylphenol, 2,6-dimethylphenol, 3,5-dimethylphenol, 4-ethoxyphenol, 4 -Ethyl-2-methoxyphenol, 4-ethyl-2-methoxyphenol, 2-ethylphenol, 3-ethyl
  • Citrasled No. 1 Sudan G, Scarlet GN, Food Yellow No. 4, Food Red No. 102, Bonso 2 R, Bonso 6 R, Food Green No. 3, Red 10 B, Food Red No. 2, Food Red No. 40 or Folic Acid is more preferable.
  • Quaternary ammonium salt is not particularly limited, and examples thereof include compounds represented by the following formulas (N1) to (N4).
  • R N11 to R N14 each independently represent an aliphatic hydrocarbon group, an aryl group, an aralkyl group or a heteroaryl group.
  • the aliphatic hydrocarbon group represented by R N11 to R N14 may be linear, branched or cyclic.
  • the aliphatic hydrocarbon group represented by R N11 to R N14 may contain a hetero atom.
  • the type of hetero atom is not particularly limited, and examples thereof include an oxygen atom, a nitrogen atom, a sulfur atom, a selenium atom, and a tellurium atom.
  • Y 1 to Y 4 are each independently selected from the group consisting of an oxygen atom, a sulfur atom, a selenium atom, and a tellurium atom. Among them, an oxygen atom or a sulfur atom is preferable from the viewpoint of easier handling.
  • t represents an integer of 1 to 3.
  • Ra, Rb and Rc each independently represent a hydrogen atom or an alkyl group having 1 to 10 carbon atoms.
  • aliphatic hydrocarbon group contains a hetero atom
  • —CH 2 — is substituted with a hetero atom.
  • an alkyl group (preferably having 1 to 30 carbon atoms, more preferably having 1 to 20 carbon atoms), an alkenyl group (having 2 to carbon atoms) 30 is preferable, and a carbon number of 2 to 20 is more preferable, or an alkynyl group (a carbon number of 2 to 30 is preferable, a carbon number of 2 to 20 is more preferable) and the like.
  • an alkyl group is preferable.
  • the aryl group represented by R N11 ⁇ R N14 e.g., an aryl group represented by R 11 in the formula (1) described above.
  • a phenyl group or a naphthyl group is preferable, for example, and a phenyl group is more preferable.
  • the aralkyl group represented by R N11 to R N14 is not particularly limited but, for example, an aralkyl group having 7 to 15 carbon atoms is preferable, and specifically, a benzyl group, a phenethyl group, a 1-naphthylmethyl group, 1- Examples include (1-naphthyl) ethyl group, triphenylmethyl group, and pyrenylmethyl group.
  • the heteroaryl group represented by R N11 to R N14 is, for example, preferably a heteroaryl group having a carbon number of 3 to 12, and examples thereof include furyl group, thiofuryl group, pyridyl group, pyrazole group, imidazolyl group, benzimidazolyl group, indolyl Groups, quinolyl group, isoquinolyl group, purine group, pyrimidyl group, pyrazyl group, oxazolyl group, thiazolyl group, triazyl group, carbazolyl group, quinoxalyl group, thiazine group and the like.
  • the aliphatic hydrocarbon group represented by R N11 to R N14 , the aryl group, the aralkyl group, and the heteroaryl group may further have a substituent.
  • substituents which can be the R 11 described above.
  • X - represents a monovalent anion other than hydroxide ions.
  • a halide ion eg, F ⁇ , Cl ⁇ , Br ⁇ , I ⁇ , Br 3 ⁇ , Br 2 Cl ⁇ , I 3 ⁇ , IBr 2 ⁇ , Cl 2 Br ⁇ , HF 2 -, H 2 F 3 -, AuBr 2 -, AuCl 2 -, AuI 2 -, and, FeCl 4 -.
  • R is a fluorine atom, a hydrocarbon group (for example, an alkyl group having 1 to 20 carbon atoms), or a perfluoro hydrocarbon group (for example, a perfluoroalkyl group having 1 to 20 carbon atoms) Borohydride anion, dichloroiodate anion, tetrafluoroborate anion, hexafluorophosphate anion, Periodate anion, sulfate anion, hydrogen anions sulfate, nitrate anions, dicyanamide anion [N - (CN) 2] , azide anion (N 3 -), alkane or arylsulfonic acid anion, perfluoro alkane or arylsulfonic acid anion , alkyl or aryl sulfate ester anions (ROSO 3 -:
  • R is represents an alkyl group or an aryl group having 6 to 18 carbon atoms having 1 to 20 carbon atoms), alkyl or aryl phosphoric acid ester anions ((RO) 2 PO 2 - : R each independently represents an alkyl group having 1 to 20 carbon atoms or an aryl group having 6 to 18 carbon atoms.)
  • Thiocyanide anion S - CN
  • triacetoxyborohydride anion triruthenate anion
  • RuO 4 - triacetoxyborohydride anion
  • X - is, X in the formula (N1) - has the same meaning as, preferred embodiments are also the same.
  • R N21 and R N22 has the same meaning as R N11 ⁇ R N14 in the formula (N1), preferred embodiments are also the same.
  • Y N21 and Y N22 are each independently, -C (R N23) 2 - , - NR N24 -, - O -, - CO -, - CO 2 -, - S -, - SO-, or, -SO 2- represents.
  • RN23 represents a hydrogen atom or a monovalent organic group selected from the group consisting of an aliphatic hydrocarbon group, an aryl group, an aralkyl group, a heteroaryl group, and a halogen atom.
  • R N24 represents a hydrogen atom or a monovalent organic group selected from the group consisting of an aliphatic hydrocarbon group, an aryl group, an aralkyl group, and a heteroaryl group.
  • the aliphatic hydrocarbon group, aryl group, aralkyl group, and heteroaryl group represented by R N23 and R N24 are aliphatic hydrocarbon groups represented by R N11 to R N14 in the formula (N1), aryl It is synonymous with a group, an aralkyl group, or a heteroaryl group, and its preferable aspect is also the same.
  • a halogen atom represented by RN23 and RN24 a fluorine atom, a chlorine atom, a bromine atom, and an iodine atom are mentioned.
  • the aliphatic hydrocarbon group, aryl group, aralkyl group or heteroaryl group represented by RN23 and RN24 may further have a substituent.
  • substituents which can be the R 11 described above.
  • R N21 or Y N22 represents -C (R N23 ) 2 -or N R24-
  • the monovalent organic group represented by R N21 is mutually linked to R N23 or R N24 to be aromatic. It may form a ring of sexic or non-aromatic nature. Also, R N21 and R N22 may be linked to each other to form an aromatic or non-aromatic ring.
  • n N represents an integer of 1 to 18.
  • X - is, X in the formula (N1) - has the same meaning as, preferred embodiments are also the same.
  • R N31 has the same meaning as R N11 to R N14 in formula (N1), and preferred embodiments are also the same.
  • Y N31 to Y N35 each independently represent a nitrogen atom or CRCR N32 ⁇ .
  • R N32 represents a hydrogen atom or a monovalent substituent.
  • the monovalent substituent represented by R N32 is not particularly limited, and examples thereof include a substituent that the above-described R 11 can be.
  • X - is, X in the formula (N1) - has the same meaning as, preferred embodiments are also the same.
  • R N41 and R N42 have the same meaning as R N11 to R N14 in formula (N1), and preferred embodiments are also the same.
  • Y N41 to Y N43 have the same meaning as Y N31 to Y N35 in formula (N3), and the preferred embodiments are also the same.
  • Y N44 represents a group represented by> NR N41 , a sulfur atom, or an oxygen atom.
  • the metal include gold, silver, copper, mercury, zinc, iron, lead, bismuth, titanium, tin, and nickel.
  • the aspect of the metal contained in the antibacterial agent containing a metal is not specifically limited, Forms, such as a metal particle, a metal ion, and a metal salt (a metal complex is included), are mentioned. Among them, gold, silver or copper is preferable as the metal in that the antibacterial property is more excellent.
  • the metal-containing antimicrobial agent may be a carrier and a metal-supported carrier containing the above-described metal supported on the carrier.
  • the type of carrier is not particularly limited, and known carriers can be used.
  • the carrier for example, inorganic oxides (eg, zeolite (crystalline aluminosilicate salt), silica gel, silicates such as clay mineral, glass (including water-soluble glass), zirconium phosphate, calcium phosphate, etc.), Activated carbon, metal carriers, organic metals and the like can be mentioned.
  • a silver-containing antibacterial agent As a metal-containing antibacterial agent, a silver-containing antibacterial agent is preferable in that it is more excellent in antibacterial property.
  • the antimicrobial agent containing silver include silver salts such as silver nitrate, silver chloride, silver sulfate, silver lactate, and silver acetate; silver complexes such as silver ammonia complex, silver chloro complex, and silver thiosulfato complex Silver particles; silver ions; silver-supported carriers on which the above-described carriers are supported; and the like.
  • Photocatalyst is not particularly limited as long as it is a substance known to exhibit a photocatalytic action, and examples thereof include TiO 2 , SrTiO 2 , ZnO, CdS, SnO 2 , and WO 3 and the like.
  • aldehyde-type compound Although it does not restrict
  • -Iodine-type compound Although it does not restrict
  • the piguanide compound is not particularly limited, and examples thereof include chlorhexidine gluconate, chlorhexidine hydrochloride, and chlorhexidine acetate.
  • the germicide, disinfectant and disinfectant may be used alone or in combination of two or more.
  • the composition of the present invention contains a bactericidal agent, a disinfectant agent, or a bactericidal agent
  • the content of the bactericidal agent, the disinfectant agent, and the bactericidal agent (the total of two or more kinds thereof) 0.001 to 10% by mass is preferable, 0.01 to 3% by mass is more preferable, and 0.01 to 1% by mass is more preferable based on the total mass.
  • composition of the present invention preferably contains a surfactant and / or an emulsifier.
  • a surfactant and / or an emulsifying agent When the composition of the present invention containing a surfactant and / or an emulsifying agent is used as a wiper by impregnating the base fabric with the composition of the present invention as a wiper, there are few unprinted parts and excellent cleaning properties.
  • the surfactant and the emulsifying agent are not particularly limited, but, for example, an ionic surfactant such as an anionic surfactant and a cationic surfactant (however, a quaternary ammonium salt may be added to the ionic surfactant mentioned herein) Not included), as well as nonionic surfactants and the like.
  • an ionic surfactant such as an anionic surfactant and a cationic surfactant (however, a quaternary ammonium salt may be added to the ionic surfactant mentioned herein) Not included), as well as nonionic surfactants and the like.
  • ionic surfactants examples include alkyl sulfates (such as sodium dodecyl sulfate), alkyl benzene sulfonates (such as sodium dodecyl benzene sulfonate), alkyl phosphates, and cholates (such as sodium deoxycholate and sodium lithocolate) And anionic surfactants such as sodium cholate); cationic surfactants such as alkyldiaminoethylglycine hydrochloride;
  • a compound having a carbon number of more than 20 is preferable.
  • specific examples of the nonionic surfactant include polyethylene glycol monolauryl ether, polyethylene glycol monostearyl ether, polyethylene glycol monocetyl ether, polyethylene glycol monolauryl ester, and polyethylene glycol monostearyl ester.
  • the emulsifier is not particularly limited, but in the case of a nonionic emulsifier, a carbon number of greater than 20 is preferred.
  • Specific examples of the emulsifying agent include oleate (in the form of salt, calcium, sodium and potassium salts), capriate (in the form of salt, calcium, sodium and Potassium salt), caprylate (salt form includes calcium salt, sodium salt and potassium salt), laurate salt (salt form includes calcium salt, sodium salt, and Potassium salts, gum rosin glycerin ester, sodium starch octenyl succinate, stearyl citrate, monoglyceride citric acid, lactic acid and fatty acid esters of glycerin, fatty acid esters of mono-, di-, or polyglycerin, stearic acid Salt (in the form of salt, calcium salt, magnesium salt, Monium salts, aluminum salts, potassium salts, and sodium salts), myristate salts (in the form of salts,
  • Palmitate in the form of salt, calcium salt, magnesium salt, ammonium salt, aluminum salt, potassium salt and sodium salt
  • calcium stearoyl lactate sodium stearoyl lactate
  • sorbitan fatty acid ester sulfosuccinic acid Dioctyl sodium, lecithin, hydroxylated lecithin, partially hydrolyzed lecithin, sunflower lecithin, enzyme-treated lecithin, propylene glycol fatty acid ester, polyoxyethylene sorbitan monolaurate, polyoxyester monostearate Len sorbitan, polyoxyethylene sorbitan tristearate, polyoxyethylene sorbitan oleate, Quillaja extract, plant sterols, sphingolipids, soy saponin, bile powder, animal sterols, fractionated lecithin, yucca foam extract, egg yolk lecithin, Tall oil and rosin glycerin ester may be mentioned.
  • cholic acid salts examples include calcium salts, sodium salts, and potassium salts.
  • Deoxycholate salt form includes calcium salt, sodium salt and potassium salt
  • oleate salt salt form includes calcium salt, sodium salt and potassium salt
  • Caprate the salt form includes calcium salt, sodium salt and potassium salt
  • caprylate salt the salt form includes calcium salt, sodium salt and potassium salt.
  • Laurate in the form of salt, calcium, sodium and potassium salts are included
  • gum rosin Esters sodium octenyl succinate, stearyl citrate, monoglycerides of citric acid, lactic acid and fatty acid esters of glycerin, fatty acid esters of mono-, di-, or polyglycerins, stearate (calcium salt in the form of a salt, Magnesium salts, ammonium salts, aluminum salts, potassium salts, and sodium salts), myristate salts (in the form of salts, calcium salts, magnesium salts, ammonium salts, aluminum salts, aluminum salts, potassium salts, and sodium salts) (In the form of salts, calcium, magnesium, ammonium, aluminum, potassium and sodium salts), calcium stearoyl lactate, sodium stearoyl lactate , Sorbitan fatty acid ester, dioctyl sodium sulfosuccinate, lecithin, hydroxy
  • the surfactant and the emulsifying agent may be used alone or in combination of two or more.
  • the content of the surfactant is preferably 0.01 to 2% by mass with respect to the total mass of the composition, 0.05 to 2% by mass is more preferable, and 0.05 to 1% by mass is more preferable.
  • the composition of the present invention preferably contains an antioxidant.
  • an antioxidant When the composition of the present invention contains an antioxidant, the antiviral activity is more excellent.
  • the antioxidant is not particularly limited, and examples thereof include “Theory and practice of antioxidants” (Enomoto, Sanshobo 1984), and “Antioxidant handbook” (Saruwatari, Nishino, Tabata, Taiseisha 1976). The various antioxidants described can be used.
  • amine compounds phenylenediamine, diphenyl-p-phenylenediamine, 4-amino-p-diphenylamine, etc.
  • calcium ethylenediaminetetraacetate disodium isopropyl citrate, guaiac fat, guaiac resin, Lauryl thiodipropionate, thiodipropionic acid, thiodipropionic acid distearyl ester, sodium thiosulfate, potassium pyrosulfite, sodium pyrosulfite, ethyl protocatechuate, potassium sulfite, sodium sulfite, potassium bisulfite, sodium bisulfite, and And stannous chloride.
  • food additives are preferable from the viewpoint of safety, and 4-hexylresorcinol, calcium ethylenediaminetetraacetate disodium isopropylate, guaiac fat, guaiac resin, dilaurylthiodipropionate, thiodipropionic acid Thiodipropionic acid distearyl ester, sodium thiosulfate, potassium metabisulfite, sodium pyrosulfite, ethyl protocatechuate, potassium sulfite, sodium sulfite, potassium bisulfite, sodium bisulfite, and stannous chloride are preferable.
  • the antioxidant may be used alone or in combination of two or more.
  • the content of the antioxidant (the total of two or more kinds thereof) is preferably 0.001 to 2% by mass with respect to the total mass of the composition, 0.01 to 2% by mass is more preferable, and 0.01 to 0.5% by mass is more preferable.
  • the pH adjuster is not particularly limited, but metal alkoxides (eg, sodium methoxide and sodium ethoxide etc.), metal oxides (eg calcium oxide and magnesium oxide etc.), hydrogen carbonates (ammonium hydrogen carbonate, carbonates) Sodium hydrogen hydrogen, potassium hydrogen carbonate and calcium hydrogen carbonate etc., metal hydroxides (calcium hydroxide, magnesium hydroxide, potassium hydroxide, sodium hydroxide, lithium hydroxide, aluminum hydroxide, rubidium hydroxide, cesium hydroxide) Strontium hydroxide, barium hydroxide, europylium hydroxide (II) and thallium hydroxide (I) etc., carbonates (ammonium carbonate, potassium carbonate, calcium carbonate, sodium carbonate, magnesium carbonate, cesium carbonate etc.), Quaternary ammonium hydroxide Organic bases (guanidine derivatives, diazabicycloundecene, and diazabicyclononene, etc.), phosphazene
  • pH adjuster those used as food additives are preferable from the viewpoint of safety, and sodium methoxide, calcium oxide, magnesium oxide, ammonium hydrogencarbonate, sodium hydrogencarbonate, potassium hydrogencarbonate, calcium hydrogencarbonate, hydroxide Calcium, magnesium hydroxide, potassium hydroxide, sodium hydroxide, ammonium carbonate, potassium carbonate, calcium carbonate, sodium carbonate or magnesium carbonate is preferred.
  • the pH adjuster may be used alone or in combination of two or more.
  • the content of the pH adjuster (the total amount of multiple pH modifiers, if any) is appropriately changed depending on the content of the specific compound and the like, and can not be limited. Is preferably 0.001 to 5% by mass, more preferably 0.005 to 3% by mass, with respect to the total mass of the composition such that the pH of the composition is greater than 9.5 and 14.0 or less. 0.01 to 2% by mass is more preferable.
  • UV absorber The UV absorber is not particularly limited, and examples thereof include paraaminobenzoic acid, ethyldihydroxypropylparaaminobenzoic acid, glyceryl paraaminobenzoic acid, octyldimethylparaaminobenzoic acid, amyl paradimethylaminobenzoate, and paradimethylaminobenzoic acid 2- 2- Para-aminobenzoic acid compounds such as ethylhexyl; 2-ethylhexyl paramethoxycinnamate (alias: octyl paramethoxycinnamate), glyceryl mono-2-ethylhexanoate diparamethoxycinnamate, 2,5-diisopropyl Methyl cinnamic acid, 2,4,6-tris [4- (2-ethylhexyloxy carbonyl) anilino] -1,3,5-triazine, methyl bis
  • the ultraviolet absorber may be used alone or in combination of two or more.
  • the content of the ultraviolet light absorber (the total of two or more kinds thereof) is preferably 0.01 to 3% by mass with respect to the total mass of the composition, 0.01 to 2% by mass is more preferable, and 0.01 to 1% by mass is more preferable.
  • the chelating agent is not particularly limited.
  • aminopolycarboxylic acid type chelating agents aromatic or aliphatic carboxylic acid type chelating agents, amino acid type chelating agents, phosphonic acid type chelating agents, phosphoric acid type chelating agents, hydroxycarboxylic acid And chelating agents, polyelectrolytes (including oligomer electrolytes), dimethylglyoxime, thioglycolic acid, phytic acid, glyoxylic acid, and glyoxal acid.
  • These chelating agents may be in free acid form or in the form of salts such as sodium salt, potassium salt, ammonium salt and the like.
  • aminopolycarboxylic acid chelating agents include ethylenediaminetetraacetic acid, ethylenediaminediacetic acid, cyclohexanediaminetetraacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, diethylenetriaminepentaacetic acid, N- (2 And-hydroxyethyl) ethylenediamine triacetic acid, glycol ether diamine tetraacetic acid, glutamic acid diacetic acid, aspartic acid diacetic acid, and salts thereof, and the like.
  • aromatic or aliphatic carboxylic acid chelating agents include oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, sebacic acid, azelaic acid, itaconic acid, aconitic acid, pyruvic acid and aminobenzoic acid.
  • acids including anthranilic acid
  • phthalic acid fumaric acid, trimellitic acid, hexahydrophthalic acid, and salts thereof.
  • amino acid based chelating agents examples include glycine, serine, alanine, lysine, cystine, cysteine, ethionine, tyrosine, methionine, and salts thereof, and the like.
  • Examples of phosphonic acid chelating agents include iminodimethylphosphonic acid, alkyldiphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid, and salts thereof.
  • Examples of phosphoric acid chelating agents include orthophosphoric acid, pyrophosphoric acid, triphosphoric acid, and polyphosphoric acid.
  • hydroxycarboxylic acid chelating agent examples include malic acid, citric acid, glycolic acid, gluconic acid, heptonic acid, tartaric acid, lactic acid, and salts thereof, and the like.
  • polymer electrolyte (including oligomer electrolyte) -based chelating agents examples include acrylic acid polymers, maleic anhydride polymers, ⁇ -hydroxyacrylic acid polymers, itaconic acid polymers, and monomers constituting these polymers.
  • the copolymer which consists of 2 or more types, and an epoxy succinic acid polymer etc. are mentioned.
  • the chelating agent may be used alone or in combination of two or more.
  • the content of the chelating agent (the total of two or more kinds thereof) is preferably 0.001 to 3% by mass with respect to the total mass of the composition.
  • the amount is more preferably 001 to 2% by mass, and still more preferably 0.001 to 1% by mass.
  • the moisturizing agent is not particularly limited.
  • deoxyribonucleic acid mucopolysaccharide, hyaluronic acid, chondroitin sulfate, aloe extract, gelatin, elastin, chitin, chitosan, hydrolyzed eggshell membrane, polyoxyethylene methyl glucoside, polyoxypropylene methyl Glucoside, sodium lactate, urea, sodium pyrrolidonecarboxylate, betaine, whey and the like can be mentioned.
  • a humectant may be used individually by 1 type, and may use 2 or more types together.
  • the content of the moisturizing agent (the total amount of the plural kinds, if present) is preferably 0.001 to 3% by mass with respect to the total mass of the composition.
  • the amount is more preferably 001 to 2% by mass, and still more preferably 0.001 to 1% by mass.
  • thickener and gelling agent for example, maleic anhydride ⁇ methyl vinyl ether copolymer, dimethyldiallylammonium chloride ⁇ acrylamide copolymer, acrylamide ⁇ acrylic acid ⁇ dimethyldiarylammonium chloride copolymer, cellulose or a derivative thereof, Keratin and collagen or derivatives thereof, calcium alginate, pullulan, agar, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, lomethoxyl pectin, guar gum, gum arabic, oat gum, acacia gum, crystalline cellulose, arabinogalactan, Karaya gum, tragacanth gum, carob bean gum, gati gum, alginic acid and salts thereof (in the form of salts, ammonium salts, potassium salts, calcium salts, and sodium salts are listed) Alginic acid and salts thereof (in the form of salts,
  • the thickener and the gelling agent may be used alone or in combination of two or more.
  • the content of the thickening agent and the gelling agent (the total of two or more kinds thereof) is 0. 0 to the total mass of the composition.
  • the content is preferably 001 to 3% by mass, more preferably 0.001 to 2% by mass, and still more preferably 0.001 to 1% by mass.
  • the preservative is not particularly limited.
  • benzoic acid sodium benzoate, potassium sorbate, sodium sorbate, sorbic acid, sodium dehydroacetate, hydrogen peroxide, formic acid, ethyl formate, sodium hypochlorite, propionic acid And sodium propionate, calcium propionate, pectin decomposition products, polylysine, phenoxyethanol, thiram, thiabendazole, imazalil, diphenyl, natamycin, fludioxonil, azoxystrobin, and tea tree oil.
  • the preservative may be used alone or in combination of two or more.
  • the content of the preservative (if there is more than one type in total) is preferably 0.001 to 3% by mass relative to the total mass of the composition, and 0.
  • the amount is more preferably 001 to 2% by mass, and still more preferably 0.001 to 1% by mass.
  • the flavoring agent is not particularly limited, and examples thereof include musk, acacia oil, anise oil, ylang oil, jasmine oil, sweet orange oil, spearmint oil, geranium oil, neroli oil, peppermint oil, cypress oil, fennel oil, peppermint oil, Bergamot oil, lime oil, lavender oil, lemon oil, lemongrass oil, rose oil, rosewood oil, anisaldehyde, shibetone, muscone, limonene and the like.
  • the fragrance may be used alone or in combination of two or more.
  • the content of the perfume (the total of two or more kinds thereof) is preferably 0.001 to 3% by mass, and more preferably 0.001 to 3% by mass with respect to the total mass of the composition. 2% by mass is more preferable, and 0.001 to 1% by mass is more preferable.
  • the pigment is not particularly limited, and examples thereof include krill pigment, orange pigment, kaolin, gunjow, chromium oxide, iron oxide, titanium dioxide, food pigment (containing no phenolic hydroxyl group), chlorophyll and the like.
  • the dyes may be used alone or in combination of two or more.
  • the content of the perfume (the total of two or more kinds thereof) is preferably 0.001 to 3% by mass, and more preferably 0.001 to 3% by mass with respect to the total mass of the composition. 2% by mass is more preferable, and 0.001 to 1% by mass is more preferable.
  • composition of the present invention can be prepared by appropriately mixing the above-described essential components and optional components.
  • order in particular of mixing of the said component is not restrict
  • the dosage form of the composition of the present invention is not particularly limited, and examples thereof include solutions, gels, aerosol sprays and non-aerosol sprays.
  • the application of the composition is not particularly limited.
  • it is preferably used as an antibacterial composition, and more preferably used as an antiviral composition.
  • antibacterial is intended to be used for acting on bacteria to reduce the activity of the bacteria
  • antiviral is intended to be used for acting on the viruses and to reduce the activity of the virus. Intended.
  • the composition of the present invention has an action of inactivating viruses belonging to, for example, Caliciviridae, Orthomyxoviridae, Coronaviridae, Herpesviridae, etc. Applications that reduce the activity of are preferred.
  • viruses belonging to the calicivirus family include viruses belonging to the genus Norovirus, Sapovirus, Lagovirus, Nebovirus and Besivirus, among which the composition belongs to viruses belonging to the genus Norovirus and It exerts a good inactivating effect against viruses belonging to the Vesivirus genus.
  • the composition is preferably used as an anti-norovirus composition, among others.
  • the method of use of the above composition is not particularly limited, but it can be applied or previously applied to a place where norovirus may adhere or may adhere.
  • the method of applying the composition is not particularly limited. For example, the method of spraying the composition onto the above location, the method of wiping the above location with a base cloth containing the composition, etc. And the like.
  • a spray according to an embodiment of the present invention comprises a spray container and a composition contained in the spray container.
  • the above composition is as described above.
  • the spray container may be an aerosol spray container or a non-aerosol spray container, and is preferably a non-aerosol spray container.
  • the spray container is intended to include, in addition to the antiviral composition, a liquid gas and a gas such as a compressed gas.
  • the spray container containing gas such as liquefied petroleum gas (LPG), dimethyl ether (DME), carbon dioxide gas, nitrogen gas, and isopentane, is mentioned specifically ,.
  • the spray container is a non-aerosol spray container
  • the spray container may be in the form of a mist, a foam, etc. of the liquid contained in the container substantially free of gas such as liquid gas and compressed gas.
  • gas such as liquid gas and compressed gas.
  • the spray container is intended to be provided with a mechanism for ejecting the liquid to the outside of the container.
  • non-aerosol spray containers include pump-type and trigger-type pressure-accumulation spray containers.
  • the spray is preferably used for antivirals, more preferably for anti-norovirus.
  • a wiper according to an embodiment of the present invention includes a backing and the above-described composition impregnated in the backing.
  • the above composition is as described above.
  • the above wiper is preferably used for antiviral use, more preferably for anti-norovirus.
  • the base fabric is not particularly limited, and may be formed of natural fibers or chemical fibers.
  • natural fibers include pulp, cotton, hemp, flax, wool, camel, cashmere, mohya and silk.
  • Chemical fibers include polyethylene terephthalate, rayon, polynozic, acetate, triacetate, nylon, polyester, polyacrylonitrile, polyvinyl alcohol, polyvinyl chloride, polyvinylidene chloride, polyethylene, polypropylene, polyurethane, polyalkylene para oxybenzoate, and polychalle etc. It can be mentioned.
  • hydrophilic base cloths are preferred in that they are easily impregnated with the composition.
  • the hydrophilic base is, for example, a base containing a fiber having a hydrophilic group such as a hydroxyl group, an amino group, a carboxy group, an amido group and a sulfonyl group.
  • a hydrophilic group such as a hydroxyl group, an amino group, a carboxy group, an amido group and a sulfonyl group.
  • Specific examples of the hydrophilic base cloth include vegetable fiber, cotton, pulp, animal fiber, rayon, nylon, polyester, polyacrylonitrile, and polyvinyl alcohol.
  • a base fabric a non-woven fabric, a cloth, a towel, a gauze, a cotton wool, etc. can be used, and a non-woven fabric is preferable.
  • the basis weight (mass per unit area) of the base fabric is preferably 100 g / m 2 or less.
  • the amount of impregnation at the time of impregnating the composition with the base fabric is preferably an amount of one or more times the mass of the base fabric.
  • Example 1 In a glass container charged with 133 mg (725 ⁇ mol) of methyl gallate, 24 mL of ethanol was added to dissolve methyl gallate in ethanol. Next, in the above-mentioned glass container, water and a 1 mol / L aqueous solution of sodium hydroxide, the total amount of water being 6 mL (ethanol concentration 80% by volume relative to the total volume of the solvent), and the composition after preparation The composition was added to give a pH of 9.6. In addition, the measurement of pH was implemented by the following method.
  • test solution 0.1 mL of the test solution was inoculated into CRFK cells (cat kidney cell line, ATCC CCL-94) cultured on an agar medium, and adsorbed at 37 ° C. for 1 hour.
  • CRFK cells cat kidney cell line, ATCC CCL-94
  • the test solution on CRFK cells was washed away, the agar medium was overlaid, and the cells were cultured for 2 to 3 days. After the culture, the number of formed plaques was counted, the infectivity titer was calculated, and this was regarded as the "infectivity titer of the composition”.
  • the infectivity titer was calculated also about the sample produced similarly to the above except having replaced with the composition and using sterilized purified water, and this was made into "the infectivity titer of control.”
  • the antiviral property (antiviral activity value) of the composition was calculated using Formula 1 below, and the calculation result was evaluated using the following criteria.
  • Antiviral activity value AB
  • A represents the common logarithm of the infectivity titer of the control.
  • B represents the common logarithm of the infectivity titer of the composition.
  • A antiviral activity value of 4.0 or more
  • B antiviral activity value of 3.5 or more and less than 4.0
  • C antiviral activity value of 3.0 or more and less than 3.5
  • D The antiviral activity value is 2.0 or more and less than 3.0
  • E The antiviral activity value is less than 2.0
  • compositions containing antiviral agents were prepared and tested respectively.
  • the antiviral activity value was calculated using 5 lots of composition per composition, and the average value was calculated based on the above evaluation criteria. It was the evaluation result of virus activity.
  • Comparative Example 4 the composition of 5 lots was prepared and tested without using the antiviral agent.
  • the content of the antiviral agent is based on mass%, and represents the content relative to the total mass of the composition.
  • the content of the solvent was 95% by mass or more with respect to the total mass of the composition.
  • W in the compound shown as an antiviral agent shows group represented by a following formula.
  • the terminal portions of the antiviral agent used in the compositions of Examples 18 and 21 are each represented by "-C 18 H 37 ". * Represents a bonding position.
  • oleyl intends an unsaturated alkyl group represented by C 18 H 35 .
  • 2-hexyloctyl intends a branched alkyl group represented by C 14 H 29 .
  • compositions of the examples exhibited excellent antiviral activity against feline calicivirus.
  • the antiviral activity of the composition against feline calicivirus is superior to the case where the pH is 10.0 or more, and further excellent when the pH is 10.5 or more (comparison of Examples 1 to 5).
  • the antiviral activity of the composition against feline calicivirus may be superior to that in the case where the alcohol content is 45% by volume or more with respect to the total volume of the solvent, and further excellent in the case of 50% by volume or more Confirmed (comparison of Examples 4 and 6 to 10).
  • Examples 41 to 55 [Preparation and Evaluation of Composition] The compositions of Examples 41 to 55 were prepared according to the composition of ingredients and pH shown in Table 2 according to the preparation method of the composition for antiviral of Example 1, and the same evaluation as Example 1 was performed.
  • the number of hydrocarbon groups is the “R of the moiety represented by * -COOR X1 , * -CONHR X1 , * -CONR X1 R X2 or * -COO-R X2 -OCO- * in each compound. Intended for the number of carbons of X1 and R X2 In addition, about * -CONR X1 R X2 , let the total carbon number of "R X1 " and "R X2 " be the number of hydrocarbon groups.
  • a virus solution obtained by cultivating feline calicivirus (Feline calicivirus: ATCC VR-782) was inoculated in the medium, dried, and wiped off with a test cloth impregnated with each composition.
  • the test carrier stainless steel plate
  • the virus remaining from the test carrier was washed out to obtain a virus solution for sample preparation.
  • a virus solution for preparing a control sample was obtained in the same manner as described above except that a test cloth impregnated with sterile purified water was used instead of the test cloth impregnated with the antiviral composition.
  • CRFK cells cultured on agar medium were inoculated with 0.1 mL of the virus solution for sample preparation, and adsorbed at 37 ° C. for 1 hour.
  • the test solution on CRFK cells was washed away, and the agar medium was overlaid and cultured for 2 to 3 days.
  • the number of plaques formed on the agar medium was counted to calculate the infectivity titer, which was defined as "infectivity titer of the composition for antiviral agent".
  • the infectivity titer was calculated also about the sample produced similarly to the above except having replaced with the virus liquid for sample preparation, and having used the virus liquid for control sample preparation, and this was made into "the infectivity titer of control.”
  • Antiviral activity value AB
  • A represents the common logarithm of the infectivity titer of the control.
  • B represents the common logarithm of the infectivity titer of the composition.
  • antiviral activity value is 2.5 or more
  • B antiviral activity value is 2.0 or more and less than 2.5
  • C antiviral activity value is less than 2.0
  • Alcohols having 3 or more carbon atoms have 2 or less carbon atoms It is assumed that the lipid solubility is higher and the surfactant function is higher than alcohol (methanol (C Log P value: -0.764), ethanol (C Log P value:-0.235)).
  • Example 56 in which the alcohol having 2 or less carbon atoms was used alone Compared with 60 and 62, it is considered that the synergistic effect of the alcohol and the phenoxide anion is further enhanced, the antiviral activity is improved, and viruses and stains can be physically removed.
  • Example 65 to 72, Comparative Example 8 [Preparation of composition] Preparation of Compositions of Examples 65 to 72 and Comparative Example 8 According to the preparation method of the composition of Example 1, the compositions of Examples 65 to 72 and Comparative Example 8 were prepared with the component combinations and pH shown in Table 4. In addition, content of an additive is content (mass%) with respect to the total mass of a composition.
  • Examples 73 to 75 Preparation of composition
  • Preparation of Compositions of Examples 73 to 75 According to the preparation method of the composition of Example 1, the compositions of Examples 73 to 75 were prepared with the component combinations and pH shown in Table 5. In addition, content of an additive is content (mass%) with respect to the total mass of a composition.
  • Example 76 to 82, Comparative Example 9 [Preparation of composition] Preparation of Compositions of Examples 76 to 82 and Comparative Example 9 According to the preparation method of the composition of Example 1, the compositions of Examples 76 to 82 were prepared with the component combinations and pH shown in Table 6. Moreover, as a composition of Comparative Example 9, an aqueous solution of sodium hypochlorite was prepared.
  • Example 76 to 80 and Example 82 having a pH of 12.0 or less It was confirmed that in the compositions of Examples 76 to 80 and Example 82 having a pH of 12.0 or less, almost no corrosion was observed on the aluminum plate, copper and brass. Some corrosion was confirmed to aluminum in Example 81 whose pH is more than 12.0.
  • sodium hypochlorite which is widely used as a norovirus disinfectant, showed some corrosion to aluminum and severe corrosion to copper and brass.
  • Example 83 to 85 Preparation of composition
  • Preparation of Examples 83 to 85 According to the preparation method of the composition of Example 1, the compositions of Examples 83 to 85 were prepared with the component combinations and pH shown in Table 7. In addition, content of an additive is content (mass%) with respect to the total mass of a composition.
  • Example 86 to 88 [Preparation of composition] Preparation of Examples 86 to 88 The compositions of Examples 86 to 88 were prepared according to the preparation method of the composition of Example 1 and at the component combinations and pH shown in Table 8.
  • compositions shown in Table 8 were evaluated for activity against influenza virus and general bacteria.
  • ⁇ Evaluation of anti-influenza virus activity> After inoculation of the virus solution obtained by culturing influenza virus (Influenza A virus (H3N2): ATCC VR-1679) in MEM (Minimum Essential Media) medium into the composition prepared above, it is stirred for 10 seconds, It was allowed to stand at about 25 ° C. for 1 minute. Next, 0.1 mL of the composition after virus solution inoculation was collected and placed in 9.9 mL of SCDLP medium (Soybean-Casein Digest Broth with Lecithin & Polysorbate 80) and mixed well to obtain a test solution.
  • SCDLP medium Soybean-Casein Digest Broth with Lecithin & Polysorbate 80
  • MDCK cells dog renal tubular epithelial derived cells, ATCC CCL-344 cultured on an agar medium, and adsorbed at 34 ° C. for 1 hour.
  • the test solution on MDCK cells was washed away, and the agar medium was overlaid and cultured for 2 to 3 days. After the culture, the number of plaques formed on the agar medium was counted to calculate the infectivity titer, which was defined as the "infectivity titer of the composition”.
  • the infectivity titer was calculated also about the sample produced similarly to the above except having replaced with the composition and using sterilized purified water, and this was made into "the infectivity titer of control.”
  • the calculation and evaluation of the antiviral activity value were performed in the same manner as the evaluation of the anti-feline calicivirus activity of Example 1.
  • composition of the present invention exhibits high activity against influenza virus and bacteria.

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Abstract

La présente invention concerne une composition qui présente une excellente activité antivirale. La présente invention concerne également une composition antimicrobienne, une composition antivirale, d'une composition anti-norovirus, une pulvérisation et une lingette qui utilisent la composition. Cette composition contient : au moins un composé choisi dans le groupe constitué par un composé A comprenant au moins deux résidus obtenus par retrait d'un ou plusieurs atomes d'hydrogène autres que des atomes d'hydrogène dans des groupes hydroxyle, dans un composé représenté par la formule (1), un composé B représenté par la formule (2), un composé C représenté par la formule (3) et un composé D représenté par la formule (4) ; et un solvant qui contient au moins un alcool. La teneur en alcool est comprise entre 40 et 100 % en volume du volume total du solvant, et le pH est supérieur à 9,5 mais inférieur ou égal à 14,0.
PCT/JP2018/039452 2017-10-31 2018-10-24 Composition, composition antimicrobienne, composition antivirale, composition anti-norovirus, pulvérisation et lingette WO2019087888A1 (fr)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007080669A1 (fr) * 2006-01-11 2007-07-19 Microbiotech Inc. Composition medicamenteuse antivirale/anti-inflammatoire
JP2009502985A (ja) * 2005-08-02 2009-01-29 ションホア （グアーンジョウ） ファーマスーティカル サイエンス アンド テクノロジー カンパニー リミテッド ウイルス感染の予防および治療用の薬剤の製造のためのヒドロキシ安息香酸エステルおよび類似体の使用
WO2009123183A1 (fr) * 2008-03-31 2009-10-08 国立大学法人広島大学 Agent antiviral et composition antivirale

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009502985A (ja) * 2005-08-02 2009-01-29 ションホア （グアーンジョウ） ファーマスーティカル サイエンス アンド テクノロジー カンパニー リミテッド ウイルス感染の予防および治療用の薬剤の製造のためのヒドロキシ安息香酸エステルおよび類似体の使用
WO2007080669A1 (fr) * 2006-01-11 2007-07-19 Microbiotech Inc. Composition medicamenteuse antivirale/anti-inflammatoire
WO2009123183A1 (fr) * 2008-03-31 2009-10-08 国立大学法人広島大学 Agent antiviral et composition antivirale

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