WO2019083007A1 - Composé pyridine, et agent de lutte contre les arthropodes nuisibles comprenant celui-ci - Google Patents

Composé pyridine, et agent de lutte contre les arthropodes nuisibles comprenant celui-ci

Info

Publication number
WO2019083007A1
WO2019083007A1 PCT/JP2018/039843 JP2018039843W WO2019083007A1 WO 2019083007 A1 WO2019083007 A1 WO 2019083007A1 JP 2018039843 W JP2018039843 W JP 2018039843W WO 2019083007 A1 WO2019083007 A1 WO 2019083007A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
compound
nmr
cdcl
methyl
Prior art date
Application number
PCT/JP2018/039843
Other languages
English (en)
Japanese (ja)
Inventor
康 片桐
拓和 高田
Original Assignee
住友化学株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 住友化学株式会社 filed Critical 住友化学株式会社
Priority to JP2019550314A priority Critical patent/JPWO2019083007A1/ja
Publication of WO2019083007A1 publication Critical patent/WO2019083007A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4

Definitions

  • the present invention relates to pyridine compounds and harmful arthropod control agents containing the same.
  • Patent Document 1 describes that certain compounds have a pest control effect.
  • An object of the present invention is to provide a compound having excellent control efficacy against harmful arthropods.
  • R 1 and R 2 are the same or different, and C1-C15 chain hydrocarbon group ⁇ The C1-C15 chain hydrocarbon group may have one or more substituents selected from group A ⁇ , C3-C8 cycloalkyl group or C3-C8 cycloalkenyl group ⁇ The C3-C8 cycloalkyl group and the C3-C8 cycloalkenyl group may have one or more substituents selected from Group B ⁇
  • R 3 represents a (C 1 -C 3 alkoxy) C 1 -C 3 alkyl group, a benzyl group optionally having one or more substituents selected from group B, a formyl group
  • R 10 represents a C1-C4 chain hydrocarbon group or a cyclopropyl group ⁇ wherein the C1-C4 chain hydrocarbon
  • n 0 or 1 and m and p are the same or different and each represents 0, 1 or 2.
  • Group A C 1 -C 6 alkoxy, C 3 -C 6 alkenyloxy, C 3 -C 6 alkynyloxy, C 1 -C 6 alkylsulfanyl, C 1 -C 6 alkylsulfinyl, C 1 -C 6 alkylsulfonyl, C 2 -C 6 alkylcarbonyl
  • a C2-C6 alkylcarbonyloxy group ⁇ wherein the C1-C6 alkoxy group, the C3-C6 alkenyloxy group, the C3-C6 alkynyloxy group, the C1-C6 alkylsulfanyl group, the C1-C6 alkylsulfinyl group, the C1 -C6 alkylsulfonyl group, the C2-C6 alkylcarbonyl group and the C2-C6 alkylcarbonyl
  • Group B C1-C6 chain hydrocarbon group, C1-C6 alkoxy group, C3-C6 alkenyloxy group, C3-C6 alkynyloxy group, C1-C6 alkylsulfanyl group, C1-C6 alkylsulfinyl group, C1-C6 alkyl A sulfonyl group, a C2-C6 alkyl carbonyl group, a C2-C6 alkyl carbonyloxy group ⁇ the C1-C6 chain hydrocarbon group, the C1-C6 alkoxy group, the C3-C6 alkenyloxy group, the C3-C6 alkynyloxy group
  • the C1-C6 alkylsulfanyl group, the C1-C6 alkylsulfinyl group, the C1-C6 alkylsulfonyl group, the C2-C6 alkylcarbonyl group and the C2-C6 alkylcarbonyloxy group have one
  • Group C A group consisting of a C1-C3 alkyl group optionally having one or more halogen atoms, a halogen atom and a cyano group.
  • Group D a group consisting of cyclopropyl, halogen and cyano.
  • a compound represented by hereinafter, referred to as a compound X of the present invention.
  • Group B is a C1-C6 chain hydrocarbon group, a C1-C6 alkoxy group, a C3-C6 alkenyloxy group, a C3-C6 alkynyloxy group, a C1-C6 alkylsulfanyl group, a C1-C6 alkylsulfinyl group, C1-C6 alkylsulfonyl group, C2-C6 alkylcarbonyl group, C2-C6 alkylcarbonyloxy group ⁇ C1-C6 chain hydrocarbon group, said C1-C6 alkoxy group, said C3-C6 alkenyloxy group, said C3-C6 alkyloxy group
  • R 2 is a C1-C10 chain hydrocarbon group ⁇
  • the C1-C10 chain hydrocarbon group has one or more substituents selected from the group consisting of a C3-C6 cycloalkyl group and a halogen atom
  • R 1 is a C1-C10 chain hydrocarbon group ⁇ wherein the C1-C10 chain hydrocarbon group has one or more substituents selected from the group consisting of a C3-C6 cycloalkyl group and a halogen atom
  • the compound according to any one of [1] to [4], which may be [6] The compound according to any one of [1] to [5], wherein L 1 and L 2 are a single bond.
  • a harmful arthropod control composition comprising the compound according to any one of [1] to [6] and an inert carrier.
  • composition according to [7] which comprises one or more components selected from the group consisting of Group (a) and Group (b): Group (a): a group consisting of an insecticidal active ingredient, an acaricidal active ingredient and a nematode active ingredient; Group (b): bactericidal active ingredient.
  • a method for controlling noxious arthropods which comprises applying an effective amount of the compound according to any one of [1] to [6] to a harmful arthropod or a habitat of the harmful arthropod.
  • a method for controlling noxious arthropods which comprises applying an effective amount of the composition according to [7] or [8] to a harmful arthropod or a habitat of the harmful arthropod.
  • a seed or vegetative organ which retains an effective amount of the compound according to any one of [1] to [6] or an effective amount of the composition according to [7] or [8].
  • harmful arthropods can be controlled.
  • halogen atom is a fluorine atom, a chlorine atom, a bromine atom or an iodine atom.
  • substituent has 2 or more halogen atoms, it means that those halogen atoms may be the same or different.
  • substituent has two or more groups or atoms selected from a specific group (for example, a group consisting of a cyano group and a halogen atom), those groups or atoms may be the same or different. .
  • the expression “optionally having one or more substituents selected from group X” is a substituent selected from group X When two or more are present, those substituents may be the same or different.
  • CX-CY in the present specification means that the number of carbon atoms is X to Y.
  • C1-C6 means that the number of carbon atoms is 1 to 6.
  • the "chain hydrocarbon group” represents an alkyl group, an alkenyl group or an alkynyl group.
  • alkyl group for example, methyl group, ethyl group, propyl group, isopropyl group, 1,1-dimethylpropyl group, 1,2-dimethylpropyl group, butyl group, tert-butyl group, pentyl group, hexyl group, Examples include octyl, decyl and pentadecyl.
  • alkenyl group for example, vinyl group, 1-propenyl group, 2-propenyl group, 1-methyl-1-propenyl group, 1-methyl-2-propenyl group, 1,2-dimethyl-1-propenyl group
  • Examples include 3-butenyl group, 4-pentenyl group, 5-hexenyl group, 7-octenyl group, 1-decenyl group and 1-pentadecenyl group.
  • alkynyl group for example, ethynyl group, 1-propynyl group, 2-propynyl group, 1-methyl-2-propynyl group, 1,1-dimethyl-2-propynyl group, 2-butynyl group, 4-pentynyl group 5-hexynyl group, 7-octynyl group, 1-decynyl group and 1-pentadecynyl group.
  • alkanediyl group for example, methanediyl group, 1,1-ethanediyl group, 1,2-ethanediyl group, 1,1-propanediyl group, 2,2-propanediyl group, 1,2-propanediyl group and There may be mentioned 1,3-propanediyl group.
  • alkenediyl group include ethene-1,1-diyl group, ethene-1,2-diyl group, 1-propene-1,2-diyl group, 1-propene-1,3-diyl group and 2- Examples include propene-1,3-diyl group.
  • cycloalkyl group for example, cyclopropyl group, cyclobutyl group, cyclopentyl group, cyclohexyl group and cyclooctyl group can be mentioned.
  • cycloalkenyl group for example, cyclopropenyl group, cyclobutenyl group, cyclopentenyl group, cyclohexenyl group and cyclooctenyl group can be mentioned.
  • the “benzyl group optionally having one or more substituents selected from group B” is, for example, benzyl group, 2-fluorobenzyl group, 4-methylbenzyl group, 4- (trifluoromethoxy) benzyl group, And 4-acetylbenzyl group.
  • each optical isomer and a mixture containing them in any ratio are also included in the compound of the present invention.
  • a compound of the present invention X includes two or more geometric isomers derived from a carbon-carbon double bond or a carbon-nitrogen double bond, and a mixture containing them in any ratio.
  • the compound of the present invention X is added with an acid such as hydrochloride, sulfate, nitrate, phosphate, acetate or benzoate by mixing with an acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid or benzoic acid May form salts.
  • an acid such as hydrochloride, sulfate, nitrate, phosphate, acetate or benzoate by mixing with an acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid or benzoic acid May form salts.
  • Embodiment 2 A compound according to Embodiment 1, wherein R 3 is a benzyl group, C (O) R 10 , C (O) OR 10 or a hydrogen atom.
  • a compound according to Aspect 4 wherein R 4 and R 5 are the same or different and are a C1-C2 alkyl group optionally having one or more halogen atoms.
  • Aspect 6 The compound according to Aspect 4, wherein R 4 and R 5 are a methyl group.
  • R 2 is a C1-C10 chain hydrocarbon group ⁇ the C1-C10 chain hydrocarbon group may have one or more substituents selected from group E ⁇ , C3-C6 cycloalkyl group or C3-C6 cycloalkenyl group ⁇ The C3-C6 cycloalkyl group and the C3-C6 cycloalkenyl group may have one or more substituents selected from group F ⁇
  • Group F a group consisting of a C1-C4 alkyl group optionally having one or more halogen atoms and a halogen atom.
  • R 2 is a C1-C10 chain hydrocarbon group ⁇ The C1-C10 chain hydrocarbon group may have one or more substituents selected from Group E ⁇ , C3-C6 cycloalkyl group or C3-C6 cycloalkenyl group ⁇ The C3-C6 cycloalkyl group and the C3-C6 cycloalkenyl group may have one or more substituents selected from group F ⁇ A compound that is [Aspect 9] In aspect 3, R 2 is a C 1 -C 10 chain hydrocarbon group ⁇ The C 1 -C 10 chain hydrocarbon group may have one or more substituents selected from group E ⁇ , C3-C6 cycloalkyl group or C3-C6 cycloalkenyl group ⁇ The C3-C6 cycloalkyl
  • R 2 is a C1-C10 chain hydrocarbon group ⁇ wherein the C1-C10 chain hydrocarbon group is at least one selected from the group consisting of a C3-C6 cycloalkyl group and a halogen atom The compound which is optionally substituted ⁇ , a C3-C6 cycloalkyl group or a C3-C6 cycloalkenyl group.
  • R 2 is a C1-C10 chain hydrocarbon group ⁇ wherein the C1-C10 chain hydrocarbon group is at least one selected from the group consisting of a C3-C6 cycloalkyl group and a halogen atom The compound which is optionally substituted ⁇ , a C3-C6 cycloalkyl group or a C3-C6 cycloalkenyl group.
  • R 2 is a C1-C10 chain hydrocarbon group ⁇ wherein the C1-C10 chain hydrocarbon group is at least one selected from the group consisting of a C3-C6 cycloalkyl group and a halogen atom The compound which is optionally substituted ⁇ , a C3-C6 cycloalkyl group or a C3-C6 cycloalkenyl group.
  • R 2 is a C1-C10 chain hydrocarbon group ⁇ wherein the C1-C10 chain hydrocarbon group is at least one member selected from the group consisting of a C3-C6 cycloalkyl group and a halogen atom The compound which is optionally substituted ⁇ , a C3-C6 cycloalkyl group or a C3-C6 cycloalkenyl group.
  • R 2 is a C1-C10 chain hydrocarbon group ⁇ wherein the C1-C10 chain hydrocarbon group is at least one selected from the group consisting of a C3-C6 cycloalkyl group and a halogen atom The compound which is optionally substituted ⁇ , a C3-C6 cycloalkyl group or a C3-C6 cycloalkenyl group.
  • R 1 is a C1-C15 chain hydrocarbon group ⁇ the C1-C15 chain hydrocarbon group may have one or more substituents selected from group E ⁇ , C3-C6 cycloalkyl group or C3-C6 cycloalkenyl group ⁇ The C3-C6 cycloalkyl group and the C3-C6 cycloalkenyl group may have one or more substituents selected from group F The compound which is ⁇ .
  • R 1 is a C1-C15 chain hydrocarbon group optionally having one or more substituents selected from group E.
  • Embodiment 23 A compound of the present invention wherein R 1 is a C1-C15 alkyl group or a C2-C15 alkenyl group.
  • R 1 is a C1-C15 chain hydrocarbon group ⁇ wherein the C1-C15 chain hydrocarbon group has one or more substituents selected from Group E.
  • Embodiment 25 The compound according to any of Embodiments 1 to 20, wherein R 1 is a C1-C15 chain hydrocarbon group optionally having one or more substituents selected from Group E.
  • Embodiment 26 A compound according to any of embodiments 1 to 20, wherein R 1 is a C1-C15 alkyl group or a C2-C15 alkenyl group.
  • Embodiment 27 A compound according to Embodiment 27, wherein R 3 is a benzyl group, C (O) R 10 , C (O) OR 10 or a hydrogen atom.
  • Embodiment 31 A compound according to Embodiment 30, wherein R 4 and R 5 are the same or different and are a C1-C2 alkyl group optionally having one or more halogen atoms.
  • R 2 is a C1-C10 chain hydrocarbon group ⁇ The C1-C10 chain hydrocarbon group may have one or more substituents selected from Group E ⁇ , C3-C6 cycloalkyl group or C3-C6 cycloalkenyl group ⁇ The C3-C6 cycloalkyl group and the C3-C6 cycloalkenyl group may have one or more substituents selected from group F ⁇
  • Group F a group consisting of a C1-C4 alkyl group optionally having one or more halogen atoms and a halogen atom.
  • R 2 is a C1-C10 chain hydrocarbon group ⁇ the C1-C10 chain hydrocarbon group may have one or more substituents selected from Group E ⁇ , C3-C6 cycloalkyl group or C3-C6 cycloalkenyl group ⁇ The C3-C6 cycloalkyl group and the C3-C6 cycloalkenyl group may have one or more substituents selected from group F ⁇
  • R 2 is a C1-C10 chain hydrocarbon group ⁇ wherein the C1-C10 chain hydrocarbon group is at least one selected from the group consisting of a C3-C6 cycloalkyl group and a halogen atom The compound which is optionally substituted ⁇ , a C3-C6 cycloalkyl group or a C3-C6 cycloalkenyl group.
  • Embodiment 41 In Embodiment 29, R 2 is a C1-C10 chain hydrocarbon group ⁇ wherein the C1-C10 chain hydrocarbon group is at least one selected from the group consisting of a C3-C6 cycloalkyl group and a halogen atom The compound which is optionally substituted ⁇ , a C3-C6 cycloalkyl group or a C3-C6 cycloalkenyl group.
  • R 2 is a C1-C10 chain hydrocarbon group ⁇ wherein the C1-C10 chain hydrocarbon group is one or more selected from the group consisting of a C3-C6 cycloalkyl group and a halogen atom The compound which is optionally substituted ⁇ , a C3-C6 cycloalkyl group or a C3-C6 cycloalkenyl group.
  • R 2 is a C1-C10 chain hydrocarbon group ⁇ wherein the C1-C10 chain hydrocarbon group is at least one selected from the group consisting of a C3-C6 cycloalkyl group and a halogen atom The compound which is optionally substituted ⁇ , a C3-C6 cycloalkyl group or a C3-C6 cycloalkenyl group.
  • R 2 is a C1-C10 chain hydrocarbon group ⁇ wherein the C1-C10 chain hydrocarbon group is at least one selected from the group consisting of a C3-C6 cycloalkyl group and a halogen atom The compound which is optionally substituted ⁇ , a C3-C6 cycloalkyl group or a C3-C6 cycloalkenyl group.
  • R 1 is a C 1 -C 15 chain hydrocarbon group ⁇ even if the C 1 -C 15 chain hydrocarbon group has one or more substituents selected from group E ⁇ , C3-C6 cycloalkyl group or C3-C6 cycloalkenyl group ⁇ wherein the C3-C6 cycloalkyl group and the C3-C6 cycloalkenyl group have one or more substituents selected from group F Compound that is good.
  • R 1 is a C1-C15 chain hydrocarbon group optionally having one or more substituents selected from group E.
  • Embodiment 49 A compound of the present invention X, wherein R 1 is a C1-C15 alkyl group or a C2-C15 alkenyl group.
  • R 1 is a C1-C15 chain hydrocarbon group ⁇ wherein the C1-C15 chain hydrocarbon group has one or more substituents selected from Group E.
  • the compound represented by the formula (Ib) (hereinafter referred to as compound (Ib)) is a compound represented by the formula (Ia) (hereinafter referred to as compound (Ia)) and the compound represented by the formula (R-1)
  • the compound (R-1) can be produced by reacting in the presence of a base.
  • R 3a represents a (C 1 -C 3 alkoxy) C 1 -C 3 alkyl group, or a benzyl group which may have one or more substituents selected from group B, and X 1 represents a chlorine atom or a bromine atom , Iodine atom, C 1 -C 10 perfluoroalkanesulfonyloxy group or tosyloxy group, and the other symbols have the same meanings as described above.
  • the reaction is usually carried out in a solvent.
  • Examples of the solvent used for the reaction include hydrocarbons such as hexane, toluene and xylene (hereinafter referred to as hydrocarbons); diethyl ether, ethylene glycol dimethyl ether, methyl tert-butyl ether (hereinafter referred to as MTBE), and tetrahydrofuran
  • hydrocarbons such as hexane, toluene and xylene
  • MTBE methyl tert-butyl ether
  • halogenated hydrocarbons such as chloroform and chlorobenzene (hereinafter referred to as halogenated hydrocarbons)
  • dimethylformamide hereinafter referred to as DMF
  • N -Aprotic polar solvents such as methyl pyrrolidone and dimethyl sulfoxide (hereinafter referred to as DMSO) (hereinafter referred to as aprotic polar solvents)
  • esters such as ethyl acetate (
  • Examples of the base used for the reaction include alkali metal carbonates such as sodium carbonate and potassium carbonate (hereinafter referred to as alkali metal carbonates); organic bases such as triethylamine and pyridine (hereinafter referred to as organic bases) .
  • alkali metal carbonates such as sodium carbonate and potassium carbonate
  • organic bases such as triethylamine and pyridine
  • the compound (R-1) is used in a proportion of usually 1 mol to 10 mol and the base is usually used in a proportion of 1 mol to 10 mol based on 1 mol of the compound (Ia).
  • the reaction time is usually in the range of 5 minutes to 72 hours.
  • the reaction temperature is usually in the range of ⁇ 20 ° C. to 100 ° C.
  • compound (Ib) can be isolated by post-treatment operations such as adding water to the reaction mixture, extracting with an organic solvent, and drying and concentrating the organic layer.
  • the compound (R-1) is a commercially available compound or can be produced according to a known method.
  • the compound represented by the formula (Ic) is a compound of the compound (Ia) and the compound represented by the formula (R-2) (hereinafter referred to as the compound (R-2)) It can be produced by reacting in the presence of [Wherein, R 3b represents C (O) R 10 or C (O) OR 10 , and the other symbols have the same meanings as described above. ]
  • the reaction is usually carried out in a solvent.
  • the solvent used for the reaction include hydrocarbons, ethers, halogenated hydrocarbons, aprotic polar solvents, esters and mixtures thereof.
  • a base used for reaction an alkali metal carbonate and organic bases are mentioned, for example.
  • the compound (R-2) is usually used in a proportion of 1 mol to 10 mol and the base is usually used in a proportion of 1 mol to 10 mol with respect to 1 mol of the compound (Ia).
  • the reaction time is usually in the range of 5 minutes to 24 hours.
  • the reaction temperature is usually in the range of ⁇ 20 ° C. to 100 ° C.
  • compound (Ic) can be isolated by performing post-treatment operations such as adding water to the reaction mixture, extracting with an organic solvent, and drying and concentrating the organic layer.
  • the compound (R-2) is a commercially available compound or can be produced according to a known method.
  • the compound represented by the formula (Id) (hereinafter referred to as a compound (Id)) is a compound of the compound (Ia) and the compound represented by the formula (R-3) (hereinafter referred to as a compound (R-3)) It can be manufactured by [Wherein, the symbols have the same meanings as described above. ]
  • the reaction is carried out without solvent or in a solvent.
  • the solvent used for the reaction include hydrocarbons, ethers, halogenated hydrocarbons, aprotic polar solvents, esters and mixtures thereof. You may use a base for reaction as needed. As a base used for reaction, organic bases are mentioned, for example.
  • the compound (R-3) is usually used in a proportion of 1 mol to 100 mol, relative to 1 mol of the compound (Ia).
  • the base is usually used in a proportion of 1 mole to 10 moles relative to 1 mole of the compound (Ia).
  • the reaction time is usually in the range of 5 minutes to 72 hours.
  • the reaction temperature is usually in the range of ⁇ 20 ° C. to 180 ° C.
  • water is added to the reaction mixture, extraction is performed with an organic solvent, and the organic layer is subjected to post-treatment operations such as drying and concentration to isolate the compound (Id).
  • the compound (R-3) is a commercially available compound or can be produced according to a known method.
  • the compound represented by the formula (Ie) (hereinafter referred to as compound (Ie)) is a compound of the compound (Ia) and the compound represented by the formula (R-4) (hereinafter referred to as compound (R-4)) It can be manufactured by [Wherein, the symbols have the same meanings as described above. ]
  • the reaction is usually carried out in a solvent.
  • the solvent used for the reaction include hydrocarbons, ethers, halogenated hydrocarbons, aprotic polar solvents, esters and mixtures thereof. You may use a base for reaction as needed.
  • the base used in the reaction examples include alkali metal hydrogen carbonates such as sodium hydrogen carbonate and potassium hydrogen carbonate (hereinafter referred to as alkali metal hydrogen carbonates); and organic bases.
  • the compound (R-4) is usually used in a proportion of 1 mole to 10 moles relative to 1 mole of the compound (Ia).
  • the base is usually used in a proportion of 1 mole to 10 moles relative to 1 mole of the compound (Ia).
  • the reaction time is usually in the range of 5 minutes to 72 hours.
  • the reaction temperature is usually in the range of ⁇ 20 ° C. to 80 ° C.
  • compound (Ie) can be isolated by post-treatment operations such as adding water to the reaction mixture, extracting with an organic solvent, and drying and concentrating the organic layer.
  • the compound (R-4) is a commercially available compound.
  • a compound represented by the formula (Ig) (hereinafter referred to as a compound (Ig)) is produced by reacting a compound represented by the formula (If) (hereinafter referred to as a compound (If)) with an oxidizing agent.
  • a compound represented by the formula (If) hereinafter referred to as a compound (If)
  • an oxidizing agent e.g., a compound (Ig)
  • the reaction is usually carried out in a solvent.
  • solvents used for the reaction include halogenated hydrocarbons; nitriles such as acetonitrile (hereinafter referred to as nitriles); esters; alcohols such as methanol and ethanol (hereinafter referred to as alcohols); acetic acid; These mixtures are mentioned.
  • the oxidizing agent used for the reaction examples include sodium periodate, m-chloroperbenzoic acid (hereinafter referred to as mCPBA) and hydrogen peroxide.
  • mCPBA m-chloroperbenzoic acid
  • hydrogen peroxide sodium carbonate or a catalyst may be used as needed.
  • tungstic acid and sodium tungstate are mentioned, for example.
  • the oxidizing agent is usually used in a proportion of 1 mole to 10 moles relative to 1 mole of the compound (If).
  • sodium carbonate sodium carbonate is usually used in a ratio of 0.01 mol to 1 mol with respect to 1 mol of compound (If).
  • the catalyst When a catalyst is used, the catalyst is usually used in a proportion of 0.01 to 0.5 mol per 1 mol of compound (If).
  • the reaction time is usually in the range of 5 minutes to 24 hours.
  • the reaction temperature is usually in the range of ⁇ 20 ° C. to 80 ° C.
  • water is added to the reaction mixture, extraction is carried out with an organic solvent, and the organic layer is optionally treated with an aqueous solution of a reducing agent (eg sodium sulfite, sodium thiosulfate) and an aqueous solution of a base (eg sodium hydrogencarbonate)
  • a reducing agent eg sodium sulfite, sodium thiosulfate
  • a base eg sodium hydrogencarbonate
  • the compound (Ia) can be produced by reacting a compound represented by the formula (M-1) (hereinafter referred to as compound (M-1)), a palladium catalyst and a base.
  • M-1 a compound represented by the formula (M-1)
  • R 30 represents a 2-propenyl group or 2-butenyl group, and the other symbols have the same meanings as described above.
  • the reaction is usually carried out in a solvent.
  • the solvent used for the reaction include halogenated hydrocarbons, alcohols, aprotic polar solvents, esters, ethers, water and mixtures thereof.
  • a base used for reaction an alkali metal carbonate and organic bases are mentioned, for example.
  • a palladium catalyst used for reaction tetrakis triphenyl phosphine palladium (0) and dibenzylidene acetone palladium (0) are mentioned, for example.
  • the palladium catalyst is usually used in a proportion of 0.01 to 0.5 mol, and the base is usually used in a proportion of 1 mol to 10 mol, relative to 1 mol of the compound (M-1).
  • the reaction time is usually in the range of 5 minutes to 24 hours.
  • the reaction temperature is usually in the range of ⁇ 20 ° C. to 80 ° C.
  • water is added to the reaction mixture, and when compound (Ia) precipitates, the solid is filtered off; compound (Ia) is isolated by post-treatment operation such as extraction with an organic solvent can do.
  • the compound represented by the formula (M-3) (hereinafter referred to as the compound (M-3)) is a compound represented by the formula (M-2) (hereinafter referred to as the compound (M-2)) and the compound represented by the formula (R) It can be produced by reacting a compound represented by -5) (hereinafter referred to as compound (R-5)).
  • R 31 is a C1-C13 chain hydrocarbon group ⁇ the C1-C13 chain hydrocarbon group may have one or more substituents selected from Group A ⁇ , C 1 -C 6 alkoxy] Group, C2-C6 alkylcarbonyl group, C2-C6 alkylcarbonyloxy group ⁇ wherein the C1-C6 alkoxy group, the C2-C6 alkylcarbonyl group and the C2-C6 alkylcarbonyloxy group have one or more halogen atoms
  • C3-C8 cycloalkyl group, or C3-C8 cycloalkenyl group ⁇ wherein the C3-C8 cycloalkyl group and the C3-C8 cycloalkenyl group have one or more substituents selected from Group B.
  • the reaction is usually carried out in a solvent.
  • the solvent used for the reaction include ethers, hydrocarbons, halogenated hydrocarbons and mixtures thereof.
  • the compound (R-5) is usually used in a proportion of 1 mole to 10 moles relative to 1 mole of the compound (M-2).
  • the reaction time is usually in the range of 5 minutes to 24 hours.
  • the reaction temperature is usually in the range of ⁇ 20 ° C. to 80 ° C.
  • the compound (M-3) can be isolated by performing post-treatment operations such as adding water to the reaction mixture and filtering and drying the precipitated solid.
  • the compound (R-5) is a commercially available compound, or can be produced, for example, according to the method described in Organic Letters, 2014, 16, 6424-6427.
  • the compound (M-2) can be produced by reacting a compound represented by the formula (M-4) (hereinafter referred to as a compound (M-4)) with an oxidizing agent.
  • a compound represented by the formula (M-4) hereinafter referred to as a compound (M-4)
  • an oxidizing agent used for the reaction include manganese (IV) oxide, Dess-Martin reagent and 2-iodoxybenzoic acid.
  • the reaction is usually carried out in a solvent.
  • the solvent used for the reaction include halogenated hydrocarbons, nitriles, esters and mixtures thereof.
  • the oxidizing agent is usually used in a proportion of 1 mole to 50 moles relative to 1 mole of the compound (M-4).
  • the reaction time is usually in the range of 5 minutes to 24 hours.
  • the reaction temperature is usually in the range of ⁇ 20 ° C. to 80 ° C.
  • water is added to the reaction mixture, extraction is performed with an organic solvent, and the organic layer is subjected to post-treatment operations such as drying and concentration to isolate the compound (M-2).
  • the compound (M-4) can be produced by reacting a compound represented by the formula (M-5) (hereinafter referred to as a compound (M-5)) with a reducing agent.
  • a compound represented by the formula (M-5) hereinafter referred to as a compound (M-5)
  • a reducing agent used for the reaction include lithium aluminum hydride, lithium borohydride and diisobutylaluminum hydride.
  • the reaction is usually carried out in a solvent.
  • the solvent used for the reaction include hydrocarbons, ethers, halogenated hydrocarbons and mixtures thereof.
  • a reducing agent is usually used in a proportion of 2 mol to 10 mol per 1 mol of compound (M-5).
  • the reaction time is usually in the range of 5 minutes to 24 hours.
  • the reaction temperature is usually in the range of -80 ° C to 40 ° C.
  • water is added to the reaction mixture, extraction is performed with an organic solvent, and the organic layer is subjected to post-treatment operations such as drying and concentration to isolate the compound (M-4).
  • the compound (M-5) is a compound represented by the formula (M-6) (hereinafter referred to as compound (M-6)) and a compound represented by the formula (R-6) (hereinafter referred to as the compound (R-6) Can be produced by reacting with [Wherein, X 2 represents a chlorine atom, a bromine atom, an iodine atom, a mesyloxy group or a tosyloxy group, and the other symbols have the same meanings as described above. ] The reaction can be carried out according to production method 1.
  • the compound (R-6) is a commercially available compound or can be produced according to a known method.
  • the compound (M-6) is a compound represented by the formula (M-7) (hereinafter referred to as a compound (M-7)) and a compound represented by the formula (M-8) (hereinafter referred to as a compound (M-8) Can be produced by reacting with [Wherein, R 33 represents a methyl group or an ethyl group, and the other symbols have the same meanings as described above. ]
  • the reaction is carried out without solvent or in a solvent.
  • the solvent used for the reaction includes, for example, ethers, hydrocarbons, aprotic polar solvents and mixtures thereof.
  • the compound (M-8) is usually used in a ratio of 0.1 to 10 moles relative to 1 mole of the compound (M-7).
  • the reaction temperature is usually in the range of -20 ° C to 200 ° C.
  • the reaction time is usually in the range of 5 minutes to 72 hours.
  • solid is collected by filtration when compound (M-6) precipitates; water is added and extracted with an organic solvent when compound (M-6) does not precipitate; To isolate compound (M-6).
  • the compound (M-7) and the compound (M-8) are commercially available compounds, or can be produced according to known methods.
  • the compound represented by the formula (M-9) (hereinafter referred to as a compound (M-9)) is a compound (M-2) and the compound represented by the formula (R-7) (hereinafter referred to as a compound (R-7) Can be produced by reacting with [Wherein, the symbols have the same meanings as described above. ] The reaction can be carried out, for example, according to the method described in Journal of Organic Chemistry, 2008, 73, 5558-5565.
  • Compound (R-7) is a commercially available compound or can be produced according to the method described in, for example, Journal of Medicinal Chemistry, 2007, 50, 6367-6382.
  • the compound represented by the formula (M-11) (hereinafter referred to as a compound (M-11)) is a compound represented by the formula (M-10) (hereinafter referred to as a compound (M-10)), the formula (R-11) It can manufacture by making the compound shown by -8) (it is hereafter described as a compound (R-8)), and a base react.
  • L 3 represents an oxygen atom
  • Compound (R-8) is a commercially available compound or can be produced according to a known method. The reaction is usually carried out in a solvent.
  • Examples of the solvent used for the reaction include hydrocarbons, ethers, halogenated hydrocarbons, aprotic polar solvents, esters and mixtures thereof.
  • Examples of the base used for the reaction include sodium hydride, alkali metal carbonates and organic bases.
  • the compound (R-8) is usually used in a proportion of 1 mol to 10 mol and the base is usually used in a proportion of 1 mol to 10 mol with respect to 1 mol of the compound (M-10).
  • the reaction time is usually in the range of 5 minutes to 24 hours.
  • the reaction temperature is usually in the range of ⁇ 20 ° C. to 100 ° C.
  • compound (M-11) can be isolated by post-treatment operation such as adding water to the reaction mixture, extracting with an organic solvent, and drying and concentrating the organic layer.
  • Reference manufacturing method 8 Compound (M-10) can be produced by reacting compound (M-4) with a chlorinating agent.
  • the chlorinating agent used for the reaction includes, for example, thionyl chloride, phosphorus oxychloride and oxalyl chloride.
  • the reaction is usually carried out in a solvent.
  • the solvent used for the reaction include hydrocarbons, halogenated hydrocarbons, ethers, nitriles, esters and mixtures thereof.
  • a chlorinating agent is usually used in a ratio of 1 mol to 10 mol per 1 mol of compound (M-4).
  • the reaction time is usually in the range of 5 minutes to 24 hours.
  • the reaction temperature is usually in the range of ⁇ 20 ° C. to 100 ° C.
  • the reaction mixture can be added with water, extracted with an organic solvent, and subjected to post-treatment procedures such as drying and concentration of the organic layer to isolate the compound (M-10).
  • the compound represented by the formula (M-13) (hereinafter referred to as the compound (M-13)) is a compound represented by the compound (M-4) or the formula (R-9) (hereinafter referred to as the compound (R-9) Can be produced by reacting a base and a base. [Wherein, the symbols have the same meanings as described above. ] The reaction may be carried out according to Reference Production Method 7 using compound (M-4) instead of compound (M-10) and compound (R-9) instead of compound (R-8). it can.
  • Compound (R-9) is a commercially available compound or can be produced according to a known method.
  • the compound represented by the formula (M-15) (hereinafter referred to as the compound (M-15)) is a compound represented by the formula (M-14) (hereinafter referred to as the compound (M-14)) and the compound represented by the formula (R-14) It can be produced by reacting the compound represented by -10) (hereinafter referred to as compound (R-10)). [Wherein, the symbols have the same meanings as described above. ] The reaction can be carried out according to Reference Production Method 6.
  • Compound (R-10) is a commercially available compound, or can be produced according to the method described in, for example, Journal of Medicinal Chemistry, 2007, 50, 6367-6382.
  • Reference manufacturing method 11 Compound (M-14) can be produced by reacting a compound represented by formula (M-16) (hereinafter referred to as compound (M-16)) with an oxidizing agent. [Wherein, the symbols have the same meanings as described above. ] The reaction can be carried out according to Reference Production Method 2.
  • Reference manufacturing method 12 Compound (M-16) can be produced by reacting a compound represented by formula (M-17) (hereinafter referred to as compound (M-17)) with a base.
  • a compound represented by formula (M-17) hereinafter referred to as compound (M-17)
  • R 34 represents a methyl group or a trifluoromethyl group, and the other symbols have the same meanings as described above.
  • the reaction is usually carried out in a solvent.
  • a solvent used for reaction alcohol is mentioned, for example.
  • a base used for reaction an alkali metal carbonate is mentioned, for example.
  • a base is usually used in a proportion of 0.1 mol to 10 mol per 1 mol of a compound (M-17).
  • the reaction time is usually in the range of 5 minutes to 24 hours.
  • the reaction temperature is usually in the range of ⁇ 20 ° C. to 80 ° C.
  • the reaction mixture can be added with water, extracted with an organic solvent, and subjected to post-treatment procedures such as drying and concentration of the organic layer to isolate the compound (M-16).
  • the compound (M-17) is a compound represented by the formula (M-18) (hereinafter referred to as compound (M-18)) and a compound represented by the formula (R-11) (hereinafter referred to as the compound (R-11) Can be produced by reacting with [Wherein, the symbols have the same meanings as described above. ]
  • the reaction is carried out without solvent or in a solvent.
  • the solvent used for the reaction include hydrocarbons, ethers, halogenated hydrocarbons and mixtures thereof.
  • the compound (R-11) is usually used in a proportion of 1 mol to 100 mol, relative to 1 mol of the compound (M-18).
  • the reaction time is usually in the range of 5 minutes to 24 hours.
  • the reaction temperature is usually in the range of ⁇ 20 ° C. to 180 ° C.
  • the reaction mixture can be added with water, extracted with an organic solvent, and subjected to post-treatment procedures such as drying and concentration of the organic layer to isolate the compound (M-17).
  • the compound (R-11) is a commercially available compound.
  • Reference manufacturing method 14 Compound (M-18) can be produced by reacting a compound represented by formula (M-19) (hereinafter referred to as compound (M-19)) with an oxidizing agent. [Wherein, the symbols have the same meanings as described above. ] The reaction can be carried out according to production method 5.
  • the compound represented by the formula (M-21) (hereinafter referred to as a compound (M-21)) is a compound represented by the formula (M-20) (hereinafter referred to as a compound (M-20)), the formula (R-20) It can be produced by reacting a compound represented by -12) (hereinafter referred to as compound (R-12)) and a base. [Wherein, the symbols have the same meanings as described above. ] The reaction can be carried out according to Reference Production Method 7.
  • the compound (R-12) is a commercially available compound or can be produced according to a known method.
  • Reference manufacturing method 16 Compound (M-20) can be produced by reacting compound (M-16) with a chlorinating agent. [Wherein, the symbols have the same meanings as described above. ] The reaction can be carried out according to the method described in Reference Production Method 8.
  • the compound represented by the formula (M-23) (hereinafter referred to as the compound (M-23)) is a compound represented by the formula (M-22) (hereinafter referred to as the compound (M-22)), the compound represented by the formula (R-22) It can be produced by reacting a compound represented by -13) (hereinafter referred to as compound (R-13)), a metal catalyst and a base.
  • X 3 represents a bromine atom or an iodine atom
  • R 35 represents a C 1 -C 13 chain hydrocarbon group ⁇ the C 1 -C 13 chain hydrocarbon group has one or more substituents selected from group A
  • group A which may be, C2-C6 alkylcarbonyl group, C2-C6 alkylcarbonyloxy group ⁇ wherein the C2-C6 alkylcarbonyl group and the C2-C6 alkylcarbonyloxy group have one or more halogen atoms
  • Examples of the metal catalyst used for the reaction include copper (I) iodide, tetrakis (triphenylphosphine) palladium (0) and dichlorobis (triphenylphosphine) palladium (II).
  • Examples of the base used for the reaction include organic bases and alkali metal carbonates.
  • the reaction is usually carried out in a solvent.
  • the solvent used for the reaction includes, for example, ethers, hydrocarbons, aprotic polar solvents and mixtures thereof.
  • the compound (R-13) is usually at a ratio of 1 mol to 10 mol, the metal catalyst is usually at a ratio of 0.01 to 0.5 mol, and the base is usually at 1 mol to 1 mol of the compound (M-22). It is used in a proportion of 1 to 100 moles.
  • the reaction time is usually in the range of 5 minutes to 48 hours.
  • the reaction temperature is usually in the range of ⁇ 20 ° C. to 80 ° C.
  • the reaction mixture can be extracted with an organic solvent, and the organic layer can be subjected to post-treatment procedures such as drying and concentration to isolate the compound (M-23).
  • the compound (R-13) is a commercially available compound or can be produced according to a known method.
  • the compound (M-22) is a compound represented by the formula (M-24) (hereinafter referred to as a compound (M-24)), and a compound represented by the formula (R-14) (hereinafter the compound (R-14) It can be produced by reacting)) with an organometallic compound.
  • the reaction is usually carried out in a solvent.
  • a solvent used for reaction hydrocarbons, ethers, and these mixtures are mentioned, for example.
  • the organic metal compound used for the reaction include C1-C4 alkyllithium and C1-C4 alkylmagnesium chloride. Lithium chloride may be used for the reaction, if necessary.
  • the compound (R-14) is usually used at a ratio of 1 mole to 10 mol and the organic metal compound is usually used at a ratio of 1 mole to 10 mol with respect to 1 mol of the compound (M-24).
  • lithium chloride lithium chloride is usually used in a proportion of 1 mole to 10 moles relative to 1 mole of the compound (M-24).
  • the reaction time is usually in the range of 5 minutes to 48 hours.
  • the reaction temperature is usually in the range of -80 ° C to 100 ° C.
  • the reaction mixture can be added with water, extracted with an organic solvent, and subjected to post-treatment procedures such as drying and concentration of the organic layer to isolate the compound (M-22).
  • Compound (R-14) is a commercially available compound or can be produced according to a known method.
  • the compound (M-24) can be produced by reacting a compound represented by the formula (M-25) (hereinafter referred to as compound (M-25)) with a compound (R-6). [Wherein, the symbols have the same meanings as described above. ] The reaction can be carried out according to production method 1.
  • the compound (M-25) is a compound represented by the formula (M-26) (hereinafter referred to as compound (M-26)) and a compound represented by the formula (R-15) (hereinafter referred to as the compound (R-15) Can be produced by reacting with [Wherein, the symbols have the same meanings as described above. ]
  • the reaction is usually carried out in a solvent.
  • a solvent used for reaction alcohol, ether, and these mixtures are mentioned, for example.
  • the compound (R-15) is usually used in a proportion of 2 mol to 20 mol per 1 mol of the compound (M-26).
  • the reaction time is usually in the range of 5 minutes to 48 hours.
  • reaction temperature is usually in the range of -20 ° C to 140 ° C.
  • compound (M-25) can be isolated by performing post-treatment procedures such as filtration and drying of the precipitated solid.
  • Compound (M-26) and compound (R-15) are commercially available compounds, or can be produced according to known methods.
  • the compound represented by the formula (M-27) (hereinafter referred to as the compound (M-27)) is a compound (M-22), the compound represented by the formula (R-16) (hereinafter the compound (R-16) Can be produced by reacting a metal catalyst and a base).
  • M represents B (OR 36 ) 2 or 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl group
  • R 36 represents a hydrogen atom or a C1-C6 alkyl group
  • the reaction is usually carried out in a solvent.
  • the solvent used for the reaction includes, for example, ethers, hydrocarbons, aprotic polar solvents, water and mixtures thereof.
  • the metal catalyst used for the reaction include tetrakis (triphenylphosphine) palladium (0), 1,1′-bis (diphenylphosphino) ferrocenepalladium (II) dichloride, tris (dibenzylideneacetone) dipalladium (0) And palladium catalysts such as palladium (II) acetate, and bis (cyclooctadiene) nickel (0).
  • a base used for reaction an alkali metal carbonate and organic bases are mentioned, for example.
  • a ligand may be used for the reaction, if necessary.
  • Examples of the ligand used for the reaction include triphenylphosphine, xanthophos, 2,2′-bis (diphenylphosphino) -1,1′-binaphthyl, 1,1′-bis (diphenylphosphino) ferrocene, 2 Dicyclohexylphosphino-2 ′, 4 ′, 6′-triisopropylbiphenyl, 2-dicyclohexylphosphino-2 ′, 6′-dimethoxybiphenyl and 1,2-bis (diphenylphosphino) ethane.
  • the compound (R-16) is usually at a ratio of 1 mol to 10 mol
  • the metal catalyst is usually at a ratio of 0.01 to 0.5 mol
  • the base is usually at 1 mol to 1 mol of the compound (M-22). It is used in a proportion of 0.1 to 5 moles.
  • the ligand is generally used in a ratio of 0.01 to 1 mole relative to 1 mole of the compound (M-22).
  • the reaction time is usually in the range of 5 minutes to 48 hours.
  • the reaction temperature is usually in the range of -20 ° C to 200 ° C.
  • reaction mixture can be extracted with an organic solvent, and the organic layer can be subjected to post-treatment procedures such as drying and concentration to isolate the compound (M-27).
  • Compound (R-16) is a commercially available compound or can be produced according to a known method.
  • the compound of the present invention or the compound of the present invention X is a group (a), a group (b), a group (c), a group (d), a group (e), a group (f), a group (g), and a group (h) And one or more components (hereinafter referred to as "the components") selected from the group consisting of The said combined use or combined use means using the compound X of the present invention and this component simultaneously, separately or at time intervals.
  • the compound of the present invention X and the component may be contained in separate formulations or may be contained in one formulation.
  • composition A containing one or more components selected from the group consisting of groups (a) and (b), and the compound X of the present invention.
  • Group (a) includes acetylcholinesterase inhibitors (eg carbamate insecticides, organophosphorus insecticides), GABAergic chloride ion channel antagonists (eg phenylpyrazole insecticides), sodium channel modulators (eg pyrethroid insecticides) Nicotinic acetylcholine receptor antagonistic modulators (eg, neonicotinoid insecticides), nicotinic acetylcholine receptor allosteric modulators, glutamatergic chloride ion channel allosteric modulators (eg, macrolide insecticides), juvenile hormone mimic , Multi-site inhibitor, chordal organ TRPV channel modulator, mite growth inhibitor, mitochondrial ATP biosynthesis enzyme inhibitor, oxidative phosphorylation uncoupling agent, nicotinic acetylcholine receptor Channel blockers (eg, nereistoxin insecticides), chitin synthesis inhibitors, molting inhibitors, ecdysone receptor
  • Group (b) includes nucleic acid synthesis inhibitors (eg, phenylamide fungicides, acyl amino acid fungicides), cell division and cytoskeleton inhibitors (eg, MBC fungicides), respiratory inhibitors (eg, QoI fungicides) , QiI fungicides), amino acid synthesis and protein synthesis inhibitors (eg, anilinopyridine fungicides), signal transduction inhibitors, lipid synthesis and membrane synthesis inhibitors, sterol biosynthesis inhibitors (eg, triazole etc.
  • nucleic acid synthesis inhibitors eg, phenylamide fungicides, acyl amino acid fungicides
  • cell division and cytoskeleton inhibitors eg, MBC fungicides
  • respiratory inhibitors eg, QoI fungicides
  • QiI fungicides QiI fungicides
  • amino acid synthesis and protein synthesis inhibitors eg, anilinopyridine fungicides
  • DMI DMI
  • bactericidal agents cell wall synthesis inhibitors, melanin synthesis inhibitors, plant defense inducers, multi-acting point contact active disinfectants, microbial disinfectants, and other bactericidal active ingredients. These are described in the classification based on the mechanism of action of FRAC.
  • Group (c) is a group of plant growth regulators (including mycorrhizal fungi and rhizobia).
  • Group (d) is a group of safeners.
  • Group (e) is a group of synergists.
  • Group (f) is a group of repellent components consisting of a bird repellent component, an insect repellent component, and an animal repellent component.
  • Group (g) is a group of mollusc components.
  • Group (h) is a group of insect pheromone.
  • alanicarb (Salyx + SX) means a combination of alanicarb (Salyx) and SX.
  • the abbreviation SX means any one compound of the present invention X selected from the compound groups SX1 to SX540 described in the Examples.
  • all of the components described below are known components and can be obtained from commercially available preparations or can be produced by known methods. When the component is a microorganism, it can also be obtained from a bacteria depository.
  • the numbers in parentheses indicate CAS RN (registered trademark).
  • Combinations of the present component of the above group (a) with the compound of the present invention Abamectin + SX, acephate + SX, acequinocyl + SX, acetamiprid + SX, acririnathrin + SX, acynonapyr + SX, afidopyropene + SX, afoxolaneal (Afoxolaner) + SX, alaniccarb (alanycarb) + SX, aldicarb (aldicarb) + SX, allethrin + SX, alpha-cypermethrin (alpha-cypermethrin) + SX, alpha-endosulfan (alpha-endosulfan) + SX, phosphorylated Aluminum (phosphide) + SX, amitraz (Amitraz) + SX, azadirachtin + SX, azamethiphos (Azamethiphos) + SX, azin
  • pomonella granulosis virus V15 (Cydia pomonella GV V15) + SX
  • C. pomonella granulosa virus V22 (Cydia pomonella GV V22) + SX
  • Cryptofrebbia leukotreta granulosa virus (Cr yptophlebia leucotreta GV) + SX
  • Dendrolimus punctatus cytoploid virus Dendrolimus punctatus cypovirus
  • SX Helicoverpa armigera nuclear polyhedrosis virus BV-0003 strain (Helicoverpa armigera NPV BV-0003) + SX
  • Helicoverpa zea Body disease virus (Helicoverpa zea NPV) + SX
  • Lymantria dispar nuclear polyhedrosis virus (Lymantria dispar NPV) + SX
  • Mamastra brassicae nuclear polyhedrosis virus (Mamestra brassicae
  • Bacillus sphaericus 2362 Bacillus sphaericus 2362 + SX, Bacillus sphaericus ABTS 1743 (Bacillus sphaericus ABTS 1743) + SX, Bacillus sphaericus Serotype H 5a 5 b (Bacillus sphaericus Serotype H 5 a 5 b) + SX, Bacillus thuringiensis AQ 52 strain (Bacillus thuringiensis AQ 52) + SX, Bacillus thuringiensis BD # 32 strain (Bacillus thuringiensis BD # 32) + SX, Bacillus thuringiensis CR-371 strain (Bacillus thuringiensis CR-371) + SX, Bacillus thuringiensis subspecies ABTS-1857 (Bacillus thuringiensis subsp.
  • Aizawai ABTS-1857 + SX, Bacillus thuringiensis subspecies AM65-52 strain (Bacillus thuringiensis subsp. Aizawai AM65-52) + SX Bacillus thuringiensis subspecies GC-91 (Bacillus thuringiensis subsp. Aizawai GC-91) + SX, Bacillus thuringin S. aiwai subspecies Serotype H-7 (Bacillus thuringiensis subsp. Aizawai Serotype H-7) + SX, Bacillus thuringiensis cristae subsp. ABTS 351 strain (Bacillus thuringiensis subsp.
  • Bacillus thuringiensis isla elensis variant serotype H-14 Bacillus thuringiensis var. israelensis serotype H- 14
  • SX Bacillus thuringiensis-Japonensis variant buibui strain (Bacillus thuringiensis var. Japonensis buibui) + SX, Bacillus thuringiensis-San Diego variant M-7 strain (Bacillus thuringiensis var. San diego M-7) + SX, Bacillus thuringiensis 7216 variant (Bacillus thuringiensis var.
  • PRAA4-1T Chromobacterium subtsugae PRAA4-1T + SX, Dactylella ellipsospora + SX, Dactylaria thaumasia + SX, Hilstera minesitensis mins.
  • pasteuria nishizawae Pn1 strain (Pasteuria nishizawae Pn1) + SX, P. pipetrae SX, Pasteuria usgae + SX, Pasteuria thoynei + SX, Serratia entomophila + SX, Verticillium chlamydosporium + SX, Vertici Lilium ⁇ recan NCIM 1312 strain (Verticillium lecani NCIM 1312) + SX, acetoprole (acetoprole) + SX, Celastrus angulatus bark (bark of Celastrus angulatus) + SX, concanamycin A (concanamycin A) + SX, sun leaf dried leaves (dried leaves) of Dryopteris filix-mas) + SX, extract of Artemisia absinthium + SX, Cassia nigricans extract (ex tract of Cassia nigricans + SX, extract of clitoria ternatea + S
  • Bacillus amyloliquefaciens strain AT332 Bacillus amyloliquefaciens AT 332) + SX
  • Bacillus amyloliquefaciens strain B3 Bacillus amyloliquefaciens B3) + SX
  • Bacillus amyloliquefaciens D747 strain Bacillus amyloliquefaciens D747) + SX
  • Bacillus amyloliquefaciens DB 101 strain Bacillus amyloliquefaciens DB101
  • Bacillus amyloliquefaciens DB 102 strain Bacillus amyloliquefaciens DB 102) + SX
  • Bacillus amyloliquefaciens GB03 strain Bacillus amyloliquefaciens GB03 strain
  • subtilis strain QST 714 Bacillus subtilis QST 714) + SX, Bacillus subtilis var. Amyloliquefaciens FZB 24 strain (Bacillus subtilis var. Amyloliquefaciens FZB24) + SX, Bacillus subtilis Y 1336 (Bacillus subtilis Y 1336) + SX, Burkholderia cepacia + SX, Burkholderia cepacia-Wisconsin type J 82 (Burkholderia cepacia type Wisconsin J 82) + SX, Burkholderia cepacia ⁇ Wisconsin M54 strain (Burkholderia cepacia type Wisconsin M54) + SX, Candida oleophila O strain (Candida oleophila O) + SX, Candida saitoana (Candida saitoana) + SX, Ketomium cupreum (Chaetium cupreum) ) + SX, Clonostachys
  • Carotobola CGE 234 M 403 strain Erwi nia carotovora subsp. carotovora CGE 234 M 403 strain (Erwi nia carotovora subsp. carotovora CGE 234 M 403) + SX, Fusarium oxysporum Fo 47 strain (Fusarium oxysporum Fo 47) + SX, Gliocladium catenulatum J 1446 (Gliocladium catenulatum J 1446) + SX, Paenibacillus polymixer AC-1 strain (Paenibacillus AC) -1) + SX, Paenibacillus polymyxa BS-0105 strain (Paenibacillus polymyxa BS-0105) + SX, Pantoea agglomerans E 325 strain (Pantoea agglomerans E 325) + SX, Flebiopsis gigantea VRA 1992 strain (Phlebiopsis gig
  • the ratio of the compound of the present invention X to the component is not particularly limited, but the weight ratio (the compound of the present invention: this component) is from 1000: 1 to 1: 1000, 500: 1 to 1: 500, 100: 1 to 1: 100, 50: 1 to 1:50, 20: 1 to 1:20, 10: 1 to 1:10, 3: 1 to 1: 3, 1: 1 to 1: 500, 1: 1 to 1: 100, 1: 1 to 1:50, 1: 1 to 1:20, 1: 1 to 1:10 and the like.
  • the compound X of the present invention is effective against noxious arthropods such as noxious insects and noxious mites, noxious nematodes, and noxious molluscs.
  • noxious arthropods such as noxious insects and noxious mites, noxious nematodes, and noxious molluscs.
  • harmful arthropods, harmful nematodes and harmful molluscs include, for example, the following.
  • Hemiptera Hemetobiunka (Laodelphax striatellus), Tobiirounka (Nilaparvata lugens), Sejirounka (Sogatella furcifera), Corn locust (Peregrinus maidis), Red-winged deer (Javesella pellucida), Black-footed Michalica Planthopper family (Delphacidae); Green leafhopper (Nephotettix cincticeps), Yellow-tailed leafhopper (Nephotettix virescens), Black-tailed green leafhopper (Nephotettix nigropictus), Yellow-tailed leafhopper (Recilia dorsalis), Black-tailed leafminus moth , Corn leaf hopper (Dalbulus maidis), white leafhopper (Cofana spectra), etc., leafhopper family (Cicadelidae); Mahanarva posticata, Mahanarva fimbriolat
  • Pecan leaf phylloxera (Phylloxera notabilis), Southern pecan leaf phylloxera (Phylloxera russellae), and the like (Phylloxeridae); (Adelgidae); rice black bug (Scot inophara lurida), Malayan rice black bug (Scot inophara coarctata), green grass bug (Nezara antennata), rhizophorid bug (Eysarcoris aeneus), dryback beetle (Eysarcoris lewisi), Red-headed Bug (Eysarcoris ventralis), Gray-backed Bug (Eysarcoris annamita), Brown-backed Bug (Halyomorpha halys), Red-headed Bug (Nezara viridula), Brown stink bug (Euschistus heros), Red banded stink bug (Piez Sturgeon (Pentatomidae) such as melacanthus; Sturgeon (Cydnidae) such as Burrower
  • Helicidae (Coreidae); , Ameri Red-tailed bug family (Lygaeidae) such as Blissus leucopterus; Red-backed squirrel (Trigonotylus caelestialium); Stink bug family (Miridae); Trichoderma faecalis (Trialeurodes vaporariorum), B. tabaci (Bemisia tabaci), Scutellaria barbata (Dialeurodes citri), Scutellaria barbata L.
  • Ameri Red-tailed bug family (Lygaeidae) such as Blissus leucopterus; Red-backed squirrel (Trigonotylus caelestialium); Stink bug family (Miridae); Trichoderma faecalis (Trialeurodes vaporariorum), B. tabaci (Bemisia tabaci), Scutellaria barbata (Dialeurodes citri), Scutellaria barbata L.
  • Lepidoptera Chilo suppressalis, Darkheaded stem borer (Chilo polychrysus), White stem borer (Scirpophaga innotata), Itten's tree magnolia (Scirpophaga incertulas), Rupela albina, Kobnomiga (Cnaphatailicalis) Casino meiga (Marasmia exigua), cotton moth (Notarcha derogata), foxtail moth (Ostrinia furnacalis), European corn borer (Ostrinia nubilalis), black-tailed moth (Hellula undulis), monquil chronome moth (Herpetogramma lucitose, Pe) Caseworms (Nymphula depunctalis), Sugarcane borer (Diatraea saccharalis), and other parts of the family (Crambidae); Ringworm (Pyralidae); Spodoptera litura, Spodoptera exigua, Mythimna separata
  • Arctiidae Giant Sugarcane b Orster (Telchin licus) Kastoniagae (Castniidae); Himebokuto (Cossus insularis) et al. (Cossidae); Family (Limacodidae); Staphymopoda (Stathmopoda niessa) etc .; Stathmopodidae; Acherontia lachesis et al. Sphingidae (Sphingidae); And the like. Seschidae (Sesiidae), etc .; Hemperididae (Hesperiidae) such as the rice tortoise (Parnara guttata);
  • Thysanoptera Thysanoptera: Thripsidae (Frankliniella occidentalis), Thripsidae (Thrips palmi), Chalyssus thripsus (Scirtothrips dorsalis), Thrips tabaci (Thrips tabaci), Hydrangea thripsus (Frankliniella intronacea) , Thripidae such as Echinothrips americanus etc .; Thripsidae (Phlaeothripidae) such as Haekohrips aculeatus.
  • Diptera Anemoneid family (Anthomyiidae) such as fly (Delia platura), onion fly (Delia antiqua), sugar beet fly (Pegomya cunicularia) etc .; Rice leafminer fly (Agromyza oryzae), tomato leafminer fly (Liriomyza sativae), bean leafminer fly (Liriomyza trifolii), leafminer fly (Chromatomyia horticola), etc.
  • Anemoneid family such as fly (Delia platura), onion fly (Delia antiqua), sugar beet fly (Pegomya cunicularia) etc .
  • Rice leafminer fly Agromyza oryzae
  • tomato leafminer fly Liriomyza sativae
  • bean leafminer fly Liriomyza trifolii
  • leafminer fly Chromatomyia horticola
  • Leafworm family (Agromyzidae); Bactrocera cucurbitae), mandarin orange fruit fly (Bactrocera dorsalis), egg fruit fly (Bactrocera latiphrons), olive fruit fly (Bactrocera oleae), quince land fruit fly (Bactrocera tryoni), citechine fruit fly (Ceratitis capitaphy) Tephritidae (Tephritidae), such as pomonella), sweet potato weeds (Rhacochlaena japonica); ; Drosophilidae such as Drosophila melanogaster (Drosophila suzukii); Psyllididae (Phoridae) such as the giant flea fly (Megaselia spiracularis); dimorphism fly family (Sciaridae) such as Hessian fly (Mayetiola destructor), Bacteriidae (Cecidomyiidae) such as incocarid fly (Ors
  • Culex quinquefasciatus Culex pipiens molestus Forskal, Culexidae such as Culex quinquefasciatus; Culicidae; Prosimulium yezoensis; House fly (Musca domestica), house fly (Muscina stabulans), sea fly (Stomoxys calcitrans), house fly (Haematobia irritans) such as house fly (Muscidae); ); (Chironomus plumosus), Chironomus yoshimatsui (Chironomus yoshimatsui), Chironomidae such as Gray midges (Glyptotendipes tokunagai) (Chironomidae); fanniidae (Fannidae).
  • Coleoptera Coleoptera (Coleoptera): Western corn rootworm (Diabrotica virgifera virgifera), Southern corn rootworm (Diabrotica undecimpunctata howardi), Northen corn rootworm (Diabrotica barberi), Mexican corn rootworm (Diabrotica virgifera zeae), Banded Cuicabiotic (Diabrotica virgifera zeae) balteata), Cucurbit Beetle (Diabrotica speciosa), Bean Leaf Beetle (Cerotoma trifurcata), Cubial Leaf Beetle (Oulema melanopus), Ground Leaf Beetle (Aulacophora femoralis), Sweet potato leaf beetle (Phyllotreta striolata), Cabbagel flea beetle (Phyllotreta pusilla), Cabbage stem flea beetle (Psylliodes chrysocephala), Colorado potato beetle (Leptinotarsa
  • Carabidae (Anomala albopilosa), Anemone carp (Popillia japonica), Anchovy (Heptophylla picea), European Chafer (Rhizotrogus majalis), Black marsh (Tomarus gibbosus), Holotrichia sp. of the genus Phyllophaga (Phyllophaga spp.), Diloboderus abderus, etc. Diloboderus (Diloboderus spp.), etc.
  • Scarabaeidae Sudabaeidae
  • postfasciatus alfalfata weevil (Hypera postica), tree weevil (Sitophilus zeamais), rice weevil (Echinocnemus squameus), rice water weevil (Lissorhoptrus oryzophilus), weed beetles (Rhabs celus lineatocollis) venatus), Southern Corn Billbug (Sphenophorus callosus), Soybean stalk weevil (Sternechus subsignatus), Sugarcane weevil (Sphenophorus levis), Crustacean weevil (Scepticus griseus), Scuticularis semen (Scepticus uniformis) , Brazilian bean weevil (Zabrotes subfasciatus), Pinus spinach (Tomicus piniperda), Coffee Berry Borer (Hypothenemus hampei), Aracanthus sp., Such as Arac
  • Ladybird family such as Epilachna vigintopoctopusta such as Coccinidae, such as Tricholium castaneum, Tribolium fascium, etc .; Epilachna vigintopoctopusta, etc .; Bostrychidae); Pantopus spp. (Ptinidae); Pteris (Anoplophora malasiaca), Migdolus fryanus etc.
  • Cerambycidae Click beetles such as common woodpeckers (Melanotus legatus), insect beetles (Anchastus spp.), Genus Conodes (Conoderus spp.), Genus Cotennisa (Ctenicera spp.), Genus Limonius (Limonius spp.), And genus Aeolus (Aeolus spp.) Family (Elateridae); Staphylinidae (Staphylinidae), such as Paederus fuscipes, etc; A beetle family (Anobidae) such as a beetle (Stegobium paniceum).
  • Orthoptera (Orthoptera): Toocta grasshopper (Locusta migratoria), Toroca grasshopper (Dociostaurus maroccanus), Australia Tobibatata (Chortoicetes terminifera), Red-footed grasshopper (Nomadacris septemfasciata), Brown Locust (Locustana pardalis Aritraceilogues) Locust (Calliptamus italicus), Differential grasshopper (Melanoplus differentialis), Two striped grasshopper (Melanoplus bivittatus), Migratory grasshopper (Melanoplus cerichelimel at least 2 times), Red-Legged grasshopper (Mel ), Yellow-winged locust (Gastrimargus musicus), Spur-throated locust (Austracris guttulosa), Kobayinago (Oxya yezoensis), Hanekinainago (Oxya japonica), Trichophyton (
  • Hymenoptera (Hymenoptera): Japanese gossip (Athalia rosae), Japanese black-billed wasp (Athalia japonica), etc. (Tenthredinidae); Fireflies (Solenopsis invicta), Red-winged Ants (Solenopsis geminata), etc. Tolushinella (Solenopsis spp. leaf-cutting ant (Atta capiguara) et al. (Atta spp.), Anemone spp. (Acromyrmex spp.), Anemone spp.
  • Black-headed ants (Formica fusca japonica), Ammet's ants (Pristomyrmex punctutus), Ascidian (Pheidole noda), Ascidian (Pheidole megacephala), Ascidian (Camponotus japonicus), Red-billed ants (Camponotus obscuripes), etc.
  • Anemone family such as the genus Quasi (Pogonomyrmex), Anopheles (Wasmania auropunctata), an ant family (Formicidae) such as Anoplolepis gracilipes, etc .
  • Vespa analis Fabriciusi Vespa velutina, Polistes jokahamae (Vespidae) such as Vespidae;
  • Cockroach (Blattodea): German cockroach (Blattella germanica) and other German cockroaches (Blattellidae); (Blattidae); Yamato termites (Reticulitermes speratus), house termites (Coptotermes formosanus), American termites (Incisitermes minor), Dicta termites (Cryptotermes domesticus), Taiwan termites (Odontotermes formosanus), red-handed termites (Neotermes) Glyptotermes satsumensis), Chinese termite (Glyptotermes nakajimai), catan termite (Glyptotermes fuscus), giant termite (Hodotermopsis sjostedti), black-and-white termite (Coptotermes guangzhouensis) , Aphid termites (Reticulitermes amamianus), Mitatake termites (Reticulitermes miyatakei), Cameron termites (Reticulitermes
  • Flea order (Siphonaptera): cat flea (Ctenocephalidae felis), dog flea (Ctenocephalides canis), castor flea (Pulex irritans), pheasant flyfish (Xenopsylla cheopis), sunanose (Tunga penetrans), chick flea (Echidnophaga gallinacea) Fleas (Nosopsyllus fasciatus).
  • Lice (Anoplura): pig lice (Haematopinus suis), lice (Haematopinus eurysternus), sheep lice (Dalmalinia ovis), lice (Linognathus seypsus), lice (Pediculus humanis), lice (Pediculucus humanus corporis) Barbed lice (Phthirus pubis).
  • Psyllids (Mallophagida): Bovine lava (Dalmalinia bovis), sheep baldness (Dalmalinia ovis) etc. Bovicola sp. (Bovicola spp.); P. Of the genus Fericola (Felocpla spp), Peanut (Lipeurus caponis) and the like Peurus (Lipeurus spp.), Trimenopon sp. (Trimenopon spp), Menopon sp. (Menopon spp.) And the like.
  • Eriophyidae such as Schizoctella (Shevtchenkella sp.); Red-handed spider mite (Tenuipalpidae) such as (Brevipalpus phoenicis); Tannertidae (Tuckerellidae); Andersoni (Dermacentor and ersoni), Ixodes ovatus, Ixodes persulcatus, Ixodes ricinus, Black legged tick (Ixodes scapularis), American kill mite (Amblyomma americanum), amblyomumium platinum ), Ixodidae such as Boophilus microplus, Boophilus annulatus, Rhipicephalus sanguineus, etc .; Tyrophagus pu Acaridae (Acaridae), such as Trichophagus similis, etc .; Dermatophagoides such as Dermatophagoides farinae, Dermatophagoides pteronyssinus, etc.
  • Arachnida (Araneae): Anemone family (Eutichuridae) such as Chehiracanthium japonicum etc .; A hymenodontid family (Theridiidae) such as Latrodectus hasseltii.
  • Obiayasuda (Polydesmida): Nephetidae (Oxidus gracilis), Red-crested cod (Nedyopus tambanus), etc.
  • Isopoda Armadillidiidae, such as Armadillium vulgare.
  • Lipopoda Chopoda: The Scutigera such as Thereuonema hilgendorfi; Scoopendra subspinipes such as Scoopendradidae; Gastropoda (Gastropoda): Black-tailed slug (Limax marginatus), black-tailed slug (Limax flavus), etc. (Limacidae); Monopidae (Ampullariidae) of the family; Monopidae (Lymnaeidae), such as the black-and-white alga (Austropheplella)
  • Nematoda Aphelenchoides sp. (Aphelenchoides besseyi etc.) Aphelenchoididae (Aphelenchoididae); And the like (Pratylenchidae), etc .; Java spp.
  • Heteroderidae such as Glossodera (Globodera pallida); Hoprolases (Hoplolaimidae), such as Rotylenchulus reniformis; Strawberry nematode (Nothotylenchus acris), jichi Anguinidae (Anguinidae) such as Lexus gypsy (Ditylenchus dipsaci); Tylenculidae (Tylenchulidae) such as Tylenchulus seminetrans; Trichodoridae); Parasitaphelenchidae such as Bursaphelenchus xylophilus.
  • Hoprolases Hoplolaimidae
  • Rotylenchulus reniformis such as Rotylenchulus reniformis
  • Strawberry nematode Nothotylenchus acris
  • jichi Anguinidae Anguinidae
  • the target harmful insects, harmful mites and other harmful arthropods, harmful molluscs and harmful nematodes have reduced drug sensitivity to insecticides, acaricides, molluscicides and nematocides, or drug resistance They may be sexually developed harmful insects, harmful arthropods such as harmful mites, harmful molluscs and harmful nematodes.
  • the targeted insecticides, acaricides, insecticides other than nematocides and nematocides, acaricides The use of a composition comprising a molluscicide and a nematocide component is desirable.
  • the compounds X of the present invention can also be used to protect plants from plant diseases caused by insect-borne viruses or insect-borne bacteria.
  • Such insect-borne viruses include, for example, the following.
  • Rice hatching virus (Rice tungro spherical virus), rice tungro bacillus virus (Rice tungro bacilliform virus), rice grassy stunt virus (Rice grassy stunt virus), rice ragged stunt virus (Rice ragged stunt virus), rice streak dead virus ( Rice stripe virus), Rice black streaked dwarf virus, Rice southern black streaked dwarf virus, Rice gall dwarf virus, Rice hoja disease (Rice hoja) blanca virus), rice yellow leaf virus (Rice yellow stunt virus), rice yellow mottle virus, rice dwarf virus, wheat cereals northern virus (Northern cereal mosaic virus), barley yellow dwarf virus (Barley yellow dwarf virus) , Barley mild mosaic virus, Barley yellow dwarf PAV Iris (Barley yellow dwarf virus-PAV), wheat yellow dwarf RPS virus (Cereal yellow dwarf virus-RPS), wheat yellow leaf virus (Wheat yellow leaf virus), Oat sterile dwarf virus, Wheat streak mosaic virus, corn dwarf mosaic virus Maize dwarf mosaic virus, Maize stripe virus, Maize chlorotic mottle virus, Maize chlorotic dwarf virus,
  • insect-borne bacteria examples include the following.
  • Rice yellow dwarf phytoplasma (Candidatus Phytoplasma oryzae), Candidatus Phytoplasma asteris, Maize bushy stunt phytoplasma, citrus greening fungus Asian type (Candidatus Liberbacter asiaticus), citrus greening fungus African type (Candidatus Liberbacter aflicanus), Type (Candidatus Liberbacter americanus).
  • the noxious arthropod controlling composition of the present invention contains the present compound, the present compound X or the composition A and an inert carrier (hereinafter referred to as the present composition).
  • the composition of the present invention is generally prepared by mixing the compound of the present invention, the compound X of the present invention or the composition A with an inert carrier such as a solid carrier, a liquid carrier, a gaseous carrier, etc.
  • Add auxiliaries for formulation add emulsion, oil, powder, granules, wettable, water dispersible granule, flowable, dry flowable, microcapsule, aerosol, poison bait, resin formulation, shampoo, It is formulated into a paste-like preparation, a foam, a carbon dioxide preparation, a tablet and the like.
  • composition of the present invention contains usually 0.0001 to 95% by weight of the compound of the present invention, the compound of the present invention X or the composition A.
  • solid carriers used in formulation include clays (kaolin clay, diatomaceous earth, bentonite, fuvasami clay, acid clay etc.), dry silica, wet silica, talc, ceramic, and other inorganic minerals (sericite, quartz, Fine powders and particles such as sulfur, activated carbon, calcium carbonate etc., chemical fertilizers (ammonium sulfate, ammonium phosphate, ammonium nitrate, urea, sodium chloride etc.) and synthetic resins (polypropylene, polyacrylonitrile, polymethyl methacrylate, polyethylene terephthalate) And polyester resins, nylon resins such as nylon-6, nylon-11, and nylon-66, polyamide resins, polyvinyl chloride, polyvinylidene chloride, vinyl chloride-propylene copolymers, and the like.
  • clays kaolin clay, diatomaceous earth, bentonite, fuvasami clay, acid clay etc.
  • dry silica wet silica,
  • liquid carriers examples include water, alcohols (methanol, ethanol, isopropyl alcohol, butanol, hexanol, benzyl alcohol, ethylene glycol, propylene glycol, phenoxyethanol etc.), ketones (acetone, methyl ethyl ketone, cyclohexanone etc.), aromatic hydrocarbons (Toluene, xylene, ethylbenzene, dodecylbenzene, phenylxylylethane, methylnaphthalene etc.), aliphatic hydrocarbons (hexane, cyclohexane, kerosene, light oil etc.), esters (ethyl acetate, butyl acetate, isopropyl myristate, Ethyl oleate, diisopropyl adipate, diisobutyl adipate, propylene glycol monomethyl ether acetate, etc., nitriles (ace
  • Gaseous carriers include, for example, fluorocarbons, butane gas, LPG (liquefied petroleum gas), dimethyl ether and carbon dioxide gas.
  • surfactants examples include nonionic surfactants such as polyoxyethylene alkyl ether, polyoxyethylene alkyl aryl ether, polyethylene glycol fatty acid ester, and anions such as alkyl sulfonate, alkyl benzene sulfonate, and alkyl sulfate. Surfactants may be mentioned.
  • fixing agents As other pharmaceutical adjuvants, fixing agents, dispersing agents, coloring agents, stabilizers and the like, specifically, for example, casein, gelatin, saccharides (starch, gum arabic, cellulose derivatives, alginic acid etc.), lignin derivatives, bentonite, Synthetic water-soluble polymers (polyvinyl alcohol, polyvinyl pyrrolidone, polyacrylic acids, etc.), isopropyl acid phosphate, 2,6-di-tert-butyl-4-methylphenol, BHA (2-tert-butyl-4-methoxyphenol) And a mixture of 3-tert-butyl-4-methoxyphenol).
  • saccharides starch, gum arabic, cellulose derivatives, alginic acid etc.
  • lignin derivatives bentonite
  • Synthetic water-soluble polymers polyvinyl alcohol, polyvinyl pyrrolidone, polyacrylic acids, etc.
  • isopropyl acid phosphate 2,6
  • Examples of the base material of the resin preparation include vinyl chloride polymers, polyurethane and the like, and phthalate esters (dimethyl phthalate, dioctyl phthalate, etc.), adipates, etc. may be used as necessary for these bases. And a plasticizer such as stearic acid may be added.
  • the resin formulation is obtained by kneading the compound in the base using a common kneading apparatus, and then molding by injection molding, extrusion molding, press molding and the like, and if necessary, through further steps such as molding and cutting, It can be processed into resin preparations such as plate-like, film-like, tape-like, net-like and string-like.
  • resin preparations are processed, for example, as animal collars, animal ear tags, sheet preparations, drawstrings, horticultural posts.
  • substrates for poison bait include cereal flour, vegetable oil, sugar, crystalline cellulose and the like, and further, if necessary, antioxidants such as dibutyl hydroxytoluene and nordihydroguaiaretic acid, preservatives such as dehydroacetic acid and the like.
  • antioxidants such as dibutyl hydroxytoluene and nordihydroguaiaretic acid
  • preservatives such as dehydroacetic acid and the like
  • an inhibitor against misphagy by children and pets such as capsicum powder, a cheese flavor, and an insect-inducing flavor such as onion flavor peanut oil are added.
  • the method of controlling a harmful arthropod of the present invention comprises directly administering an effective amount of the compound of the present invention, the compound of the present invention or the composition of the present invention to the harmful arthropod and / or Application to soil, house, animals etc. It can also be applied to seeds.
  • Examples of the application method of the compound of the present invention, the compound X of the present invention or the composition of the present invention include stem and leaf treatment, soil treatment, root treatment, shower treatment, smoke treatment, water surface treatment and seed treatment.
  • plants include whole plants, stems and leaves, flowers, ears, fruits, trunks, branches, crowns, seeds, vegetative organs and seedlings.
  • the vegetative organ means the plant roots, stems, leaves, etc. that have the ability to grow when the site is separated from the main body and installed in the soil.
  • the vegetative reproductive organs for example, tuberous root, creeping root, bulb, corm or solid bulb, tuber, tuber, rhizome, stolon Rhizophores, cane cuttings, propagule and vine cutting.
  • a toothpick is also called a runner (runner), and a basket is also called a sprout and is divided into a broad bud and a bulbil (bulbil).
  • “Vine” means shoots such as sweet potato and yam (collectively referred to as leaves and stems, shoot).
  • bulbs corms, tubers, rhizomes, stem fragments, rhizomes or tuberous roots are collectively referred to as bulbs. Cultivation of potato starts by planting tubers in the soil, but the tubers used are generally called seed potatoes.
  • the compound X of the present invention or the composition of the present invention As a method of applying an effective amount of the compound of the present invention, the compound X of the present invention or the composition of the present invention to a plant or a soil for cultivating plants, for example, the compound of the present invention, the compound of the present invention X or the composition of the present invention
  • the method of applying the effective dose of this invention compound, this invention compound X, or this invention composition to the soil after planting is mentioned.
  • a method for controlling an arthropod pest by applying an effective amount of the compound of the present invention, the compound X of the present invention or the composition of the present invention to the soil before planting or after planting is, for example, Method of directly controlling harmful arthropods by applying an effective amount of the compound of the present invention, the compound of the present invention or the composition of the present invention to the rhizosphere of a crop to be protected from damage such as feeding by animals And the effective amount of the compound of the present invention, the compound of the present invention, or the composition of the present invention into the interior of the plant body to control a harmful arthropod feeding on a plant.
  • the application amount thereof is usually 1 to 10000 g in the amount of the compound of the present invention or compound X of the present invention per 10000 m 2 It is.
  • the amount of the compound of the present invention or the compound X of the present invention is usually 0.001 to 100 g based on 1 Kg of seeds or vegetative organs.
  • the application rate of composition A is usually 0.001 to 100 g per kg of seed or vegetative organ.
  • compound X of the present invention or composition A is formulated into an emulsion, a wettable powder, a flowable, etc., it is usually diluted with water so that the concentration of the active ingredient is 0.01 to 10000 ppm. And granules, dusts, etc. are usually applied as such.
  • formulations and their dilutions may be sprayed directly onto plants, such as harmful arthropods or crops to be protected from harmful arthropods, and harmful arthropods that inhabit the soil of cultivated land
  • the soil may be treated to control.
  • the resin preparation processed into a sheet or string can be treated by a method such as wrapping around a crop, spreading it in the vicinity of a crop, spreading it on stock soil, or the like.
  • the application amount thereof is the compound of the present invention per 1 m 2 of treated area or an amount of the present compound X, usually from 0.01 ⁇ 1000 mg, in an amount of compound of the invention or the invention compound X per processing space 1 m 3 if the process in the space, generally 0.01 ⁇ 500 mg It is.
  • compound X of the present invention or composition A is formulated into an emulsion, a wettable powder, a flowable, etc., it is usually diluted with water so that the concentration of the active ingredient is 0.1 to 10000 ppm. Apply oil, aerosol, smoke, poison bait etc. as it is.
  • the compound of the present invention X or the composition of the present invention is used for ectoparasite control of small animals such as cattle, horses, pigs, sheep, goats and chickens, domestic animals such as dogs, cats, rats and mice It can be used on animals in a manner known in the art.
  • small animals such as cattle, horses, pigs, sheep, goats and chickens
  • domestic animals such as dogs, cats, rats and mice
  • systemic suppression for example, it is administered by tablet, feed mixing, suppository, injection (intramuscular, subcutaneous, intravenous, intraperitoneal etc.) and is intended for non-systemic suppression.
  • the amount of the compound of the present invention or the compound of the present invention X when administered to an animal is usually in the range of 0.1 to 1000 mg per 1 kg of animal weight.
  • the compound of the present invention, the compound of the present invention X or the composition of the present invention can be used as a control agent for arthropod pests in agricultural land such as fields, paddy fields, lawns, orchards. Examples of plants include the following.
  • Agricultural products corn, rice, wheat, barley, rye, oats, sorghum, cotton, soybeans, peanuts, buckwheat, sugar beet, rapeseed, sunflower, sugar cane, tobacco etc.
  • Vegetables Solanaceous vegetables (eggplant, tomatoes, peppers, peppers, potatoes, etc.), Cucurbitaceae vegetables (eg, cucumbers, pumpkins, zucchini, watermelons, melons, etc.), Brassicaceae vegetables (radish, turnip, horseradish, kohlrabi, Chinese cabbage, cabbage) , Mustard, broccoli, cauliflower etc.), Asteraceae vegetables (eg burdock, shung chrysanthemum, artichoke, lettuce etc.), a liliaceous vegetables (scallion, onion, garlic, asparagus etc.), vegidaceae vegetables (carrots, parsley, celery, American buffalo) Etc.), vecoraceae vegetables (spinach, swiss char
  • Fruits Fruits; Fruits (apples, pears, Japanese pears, cullins, quince etc.), Core fruits (momo, plums, nectarines, jujubes, apricots, prunes etc.), citrus fruits (palms, oranges, lemons, limes, grapefruits) Etc), nuts (nuts, walnuts, hazelnuts, almonds, pistachios, cashews, macadamias etc), berries (blueberries, cranberries, blackberries, raspberries etc), grapes, oysters, olives, loquats, bananas, coffee, etc. Date palm, coconut palm, etc.
  • Trees other than fruit trees tea, mulberry, flowering trees, street trees (astera, birch, dogwood, eucalyptus, eucalyptus, ginkgo, lilac, maple, oak, poplar, persimmon, perennial, fusarium, plananas, persimmon, perianthus, birch, fir tree, tsuga, nezu, pine Spruce, yew etc. etc.
  • the above-mentioned plants also include plants which can be produced by natural mating, plants which can be generated by mutation, F1 hybrid plants and genetically modified crops.
  • genetically modified crops include HPPD (4-hydroxyphenylpyruvate dioxygenase enzyme) inhibitors such as isoxaflutole, ALS (acetolactate synthetase) inhibitors such as imazethapyr and thifensulfuron methyl, EPSP (5 -Plants with resistance to herbicides such as -enolpyruvyl shikimate-3-phosphate synthetase inhibitor, glutamine synthetase inhibitor, PPO (protoporphyrinogen oxidase) inhibitor, bromoxynil, or dicamba
  • HPPD 4-hydroxyphenylpyruvate dioxygenase enzyme
  • ALS acetolactate synthetase
  • EPSP -Plants with resistance to herbicides such as -enolpyruvyl
  • the above-mentioned plant is not particularly limited as long as it is a commonly grown variety.
  • Me represents a methyl group
  • Et represents an ethyl group
  • Pr represents a propyl group
  • iPr represents an isopropyl group
  • Bu represents a butyl group
  • Pen represents a pentyl group
  • Hex hexyl.
  • TBu represents a tert-butyl group
  • cPr represents a cyclopropyl group
  • cBu represents a cyclobutyl group
  • cPen represents a cyclopentyl group
  • cHex represents a cyclohexyl group
  • Ph represents a phenyl group.
  • CHMeCH 2 CH 3 represents a 1-methylpropyl group
  • (CH 2) 2 CHMe 2 represents a 3-methylbutyl group
  • C ⁇ CcHex represents a 2-cyclohexylethynyl group
  • cPr, cBu, cPen and cHex have a substituent, the substituent is indicated before the symbol together with the substitution position.
  • 3,3-Me 2 -cBu represents a 3,3-dimethylcyclobutyl group
  • CH 2 (4-OMe-cHex) represents a (4-methoxycyclohexyl) methyl group.
  • Reference Production Example 15 The compounds produced according to the method described in Reference Production Example 14 and the physical properties thereof are shown below.
  • Formula (A-9) In the compounds represented by the above, compounds wherein R 2x is described in [Table 2].
  • Reference Production Example 17 The compounds produced according to the method described in Reference Production Example 16 and the physical properties thereof are shown below. In the compounds represented by formula (A-9), compounds wherein R 2x is as described in [Table 3].
  • the present compound 1 1 H-NMR (CDCl 3 ) ⁇ : 6.60-6.48 (0.5 H, m), 6.28 (0.5 H, d), 6.14 (0.5 H, d), 5. 76-5. 65 (0.5 H, m) , 2.36-2.11 (7H, m), 2.01 (3H, s), 1.89-1.78 (1H, m), 1.51-1.14 (12H, m), 0.90-0.81 (3H, m).
  • Production Example 2 The compounds produced according to the method described in Production Example 1 and the physical properties thereof are shown below.
  • Formula (A-2) In the compounds shown by these, compounds in which R 1x and R 2x are any combination of those described in [Table 4].
  • the present compound 6 1 H-NMR (CDCl 3 ) ⁇ : 6.57-6.45 (1 H, m), 6.34-6.18 (1 H, m), 5.87-5. 75 (1 H, m), 2. 35 (1.5 H, s), 2.31 (1.5 H, s), 2. 27 (1.5 H, s), 2. 19 (1.5 H, s), 2.01 (1.5 H, s), 2.02 (1.5 H, s), 1. 84 (1.5 H, dd), 1.50 (1.5 H, s) 1.5 H, dd).
  • the present compound 8 1 H-NMR (DMSO-d 6 ) ⁇ : 2.17 (6H, s), 1.80 (6H, s).
  • the present compound 9 1 H-NMR (CDCl 3 ) ⁇ : 9.77 (0.5 H, s), 9. 50 (0.5 H, s), 7.
  • the present compound 10 1 H-NMR (CDCl 3 ) ⁇ : 8.45 (0.5 H, s), 8.34 (0.5 H, s), 6.63 to 6.72 (0.5 H, m), 6.51 (0.5 H, d), 6.32 (0.5H, d), 5.80-5.88 (0.5H, m), 2.91-3.02 (1H, m), 2.75-2.87 (1H, m), 2.36 (1.5H, s), 2.29 (1.5 H, s) , 2.27 (1.5 H, s), 2.21 (1.5 H, s), 2.02 (3 H, s).
  • the present compound 16 1 H-NMR (CDCl 3 ) ⁇ : 8.08 (1 H, s), 4.55 (2 H, s), 3.42-3. 31 (1 H, m), 2.79-2.67 (2 H, m), 2.
  • the present compound 20 1 H-NMR (CDCl 3 ) ⁇ : 2.46 (3H, s), 2.37 (3H, s), 2.13 (2H, t), 2.03 (3H, s), 1.49-1 to 38 (2H, m) ), 0.92 (3H, t).
  • Invention compound 98 1 H-NMR (CDCl 3 ) ⁇ : 8.38 (1 H, s), 6.78 (0.5 H, dt), 6.41 (0.5 H, d), 6.20 (0.5 H, d), 5.79 (0.5 H , dt), 2.58-2.39 (3H, m), 2.37 (1.5H, s), 2.32-2.24 (1H, m), 2.29 (1.5H, s), 2.28 (1.5H, s), 2.22 (1.5H) , s), 2.02 (3H, s).
  • the present compound 99 1 H-NMR (CDCl 3 ) ⁇ : 9.40 (0.5 H, s), 9.14 (0.5 H, s), 6.37-6.24 (1 H, m), 6.13-6.06 (0.5 H, m), 5.82-5.70 (0.5 H, m), 3.45 (0.5 H, m), 3.19 (0.5 H, m), 2. 32 (1.5 H, s), 2.30 (1.5 H, s), 2.20-2.08 (1 H, m) , 2.01 (1.5 H, s), 2.00 (1.5 H, s), 1.92-1. 83 (1 H, m), 1.51-1. 29 (2 H, m), 1.
  • Invention compound 121 1 H-NMR (CDCl 3 ) ⁇ : 5.17 (0.5 H, m), 4.95 (0.5 H, m), 3.38 (1 H, s), 3.25 (1 H, s), 2.27 (1.5 H, s), 2.25 (1.5 H, s), 2.21 (1.5 H, s), 2.21 (1.5 H, s), 2.18 (1 H, m), 2.02 (1.5 H, s), 2.02 (1.5 H, s), 1.94 (1 H, m), 0.59 (1.5 H, s), 1.51 (1.5 H, s), 0.99 (1.5 H, t), 0.87 (1.5 H, t).
  • the present compound 25 1 H-NMR (CDCl 3 ) ⁇ : 10.15 (1H, s), 5.88 (1H, s), 3.39 (6H, s), 2.45 (3H, s), 2.29 (3H, s), 2.00 (3H, s).
  • the present compound 26 1 H-NMR (CDCl 3 ) ⁇ : 2.46 (3H, s), 2.37 (3H, s), 2.13 (2H, t), 2.03 (3H, s), 1.49-1 to 37 (2H, m) ), 0.92 (3H, t).
  • the present compound 27 1 H-NMR (CDCl 3 ) ⁇ : 6.13 (0.5 H, d), 6.03 (0.5 H, d), 5.92-5. 74 (1 H, m), 2.50 (1.5 H, s), 2.48 1.5 H, s), 2. 47 (1.5 H, s), 2. 39 (1.5 H, s), 2. 28 (1.5 H, s), 2. 25 (1.5 H, s), 2.23-2.15 (1 H, m), 2.07 (1.5) H, s), 2.05 (1.5 H, s), 1.80-1.89 (1 H, m), 1.49-1 .16 (12 H, m), 0.93-0.83 (3 H, m).
  • Production Example 6 The compounds produced according to the method described in Production Example 5 and the physical properties thereof are shown below.
  • Formula (A-3) In the compound shown by these, compounds in which R 1x and R 2x are any combination described in [Table 5].
  • the present compound 28 1 H-NMR (CDCl 3 ) ⁇ : 6.13 (0.5 H, d), 6.04 (0.5 H, d), 5.88 (0.5 H, m), 5. 78 (0.5 H, m), 2.50 (1.5 H, s), 2.48 (1.5 H, s), 2. 47 (1.5 H, s), 2. 39 (1.5 H, s), 2. 28 (1.5 H, s), 2. 25 (1.5 H, s), 2. 20 (1 H, m) ), 2.07 (1.5 H, s), 2.05 (1.5 H, s), 1. 84 (1 H, m), 1. 45 (1 H, m), 1.33 (3 H, m), 1.22 (2 H, m), 0.91 (1.5 H) , t), 0.84 (1.5 H, t).
  • the compound of the present invention 29 1 H-NMR (CDCl 3 ) ⁇ : 6.13 (0.5 H, d), 6.04 (0.5 H, d), 5.87 (0.5 H, m), 5. 78 (0.5 H, m), 2.50 (1.5 H, s), 2.48 (1.5 H, s), 2.47 (1.5 H, s), 2. 39 (1.5 H, s), 2. 28 (1.5 H, s), 2. 25 (1.5 H, s), 2.21 (1 H, m) ), 2.07 (1.5 H, s), 2.05 (1.5 H, s), 1. 85 (1 H, m), 1.41 (2 H, m), 1. 27 (2 H, m), 0.93 (1.5 H, t), 0.83 (1.5) H, t).
  • the present compound 30 1 H-NMR (CDCl 3 ) ⁇ : 6.14 (0.5 H, d), 6.05 (0.5 H, d), 5.95-5.75 (1 H, m), 2.50 (1.5 H, s), 2.48 3H, s), 2. 39 (1.5 H, s), 2. 28 (1.5 H, s), 2. 25 (1.5 H, s), 2.23-2.13 (1 H, m), 2.08 (1.5 H, s), 2.05 (1.5 H) , s), 1.88-1.79 (1 H, m), 1.51-1. 43 (1 H, m), 1.41-1. 30 (1 H, m), 0.96 (1.5 H, t), 0.84 (1.5 H, t).
  • the present compound 31 1 H-NMR (CDCl 3 ) ⁇ : 6.13 (0.5 H, d), 6.02 (0.5 H, d), 5. 93 (0.5 H, m), 5. 77 (0.5 H, m), 2.50 (1.5 H, s), 2.48 (1.5 H, s), 2.47 (1.5 H, s), 2. 39 (1.5 H, s), 2. 29 (1.5 H, s), 2. 26 (1.5 H, s), 2.22 (1 H, m) ), 2.07 (1.5 H, s), 2.05 (1.5 H, s), 1. 86 (1 H, m), 1.09 (1.5 H, t), 0.93 (1.5 H, t).
  • the compound of the present invention 32 1 H-NMR (CDCl 3 ) ⁇ : 6.16 (0.5 H, d), 6.09 (0.5 H, d), 5.98-5.84 (1 H, m), 2.50 (1.5 H, s), 2.48 3H, s), 2. 39 (1.5 H, s), 2. 29 (1.5 H, s), 2. 26 (1.5 H, s), 2.08 (1.5 H, s), 2.05 (1.5 H, s), 1. 88 (1.5 H, s) dd), 1.51 (1.5 H, dd).
  • the present compound 33 1 H-NMR (CDCl 3 ) ⁇ : 6.53 (1 H, dd), 5.52 (1 H, dd), 5.48 (1 H, dd), 2.50 (3 H, s), 2.49 (3 H, s), 2.30 (3H, s), 2.06 (3H, s).
  • the present compound 34 1 H-NMR (CDCl 3 ) ⁇ : 2.47 (6H, s), 2.36 (3H, s), 2.04 (6H, s).
  • the present compound 35 1 H-NMR (CDCl 3 ) ⁇ : 6.76 (0.5 H, dd), 6.53 (0.5 H, t), 6.21 (0.5 H, d), 5.98 (0.5 H, d), 5.95 (0.5 H, d), 5.58 (0.5 H, d), 2. 48 (1.5 H, s), 2.51 (3 H, s), 2. 39 (1.5 H, s), 2. 29 (1.5 H, s), 2.22 (1.5 H, s) ), 2.08 (1.5 H, s), 2.06 (1.5 H, s), 1. 85 (1.5 H, s), 1.81 (3 H, s), 1. 74 (1.5 H, s).
  • the present compound 36 1 H-NMR (CDCl 3 ) ⁇ : 6.46-6.38 (1H, m), 5.91-5.80 (1H, m), 3.06-2.94 (1H, m), 2.75-2.63 (1H, m) , 2.52 (1.5 H, s), 2. 49 (1.5 H, s), 2. 47 (1.5 H, s), 2. 39 (1.5 H, s), 2. 28 (1.5 H, s), 2. 25 (1.5 H, s), 2.08 (1.5 H, s), 2.06 (1.5 H, s).
  • the present compound 37 1 H-NMR (CDCl 3 ) ⁇ : 6.08 (0.5 H, d), 5.90 (0.5 H, d), 5.82 (0.5 H, dd), 5.61 (0.5 H, dd), 2.50 (1.5 H, s), 2.48 (1.5 H, s), 2.46 (1.5 H, s), 2.40 (1.5 H, s), 2.28 (1.5 H, s), 2.26 (1.5 H, s), 2.18-2.09 (1 H) , m), 2.07 (1.5 H, s), 2.05 (1.5 H, s), 1.89-1.49 (5 H, m), 1.39-0.99 (5 H, m).
  • the present compound 38 1 H-NMR (CDCl 3 ) ⁇ : 6.71 (0.5 H, d), 6.17 (0.5 H, d), 5. 44 (0.5 H, d), 5.05 (0.5 H, d), 3.68 (1.5 H, s), 3.66 (1.5 H, s), 2. 49 (1.5 H, s), 2. 48 (3 H, s), 2. 45 (1.5 H, s), 2.31 (1.5 H, s), 2. 30 (1.5 H, s) ), 2.05 (3H, s).
  • the present compound 39 1 H-NMR (CDCl 3 ) ⁇ : 4.42 (2H, s), 3.92 (3H, s), 3.31 (3H, s), 2.57 (3H, s), 2.50 (3H, s), 2.10 (3H, s).
  • the present compound 40 1 H-NMR (CDCl 3 ) ⁇ : 8.16 (1H, s), 3.97 (3H, s), 2.60 (3H, s), 2.51 (3H, s), 2.35 (3H, s), 2.09 (3H, s).
  • the present compound 41 1 H-NMR (CDCl 3 ) ⁇ : 4.99 (2H, s), 2.60 (3H, s), 2.50 (3H, s), 2.35 (3H, s), 2.05 (3H, s), 1.83 (3H, s), 1.77 (3H, s).
  • Invention compound 42 1 H-NMR (CDCl 3 ) ⁇ : 5.34 (1H, s), 3.45 (6H, s), 2.61 (3H, s), 2.49 (3H, s), 2.34 (3H, s), 2.04 (3H, s).
  • Invention compound 43 1 H-NMR (CDCl 3 ) ⁇ : 2.54 (3H, s), 2.49 (3H, s), 2.44 (2H, t), 2.36 (3H, s), 2.07 (3H, s), 1.68-1.58 (2H, m), 1.06 (3H, t).
  • Invention compound 44 1 H-NMR (CDCl 3 ) ⁇ : 4.41 (2H, s), 3.31-3.22 (1H, m), 2.57 (3H, s), 2.48 (3H, s), 2.36 (3H, s) ), 2.04 (3H, s), 1.97-1.87 (2H, m), 1.81-1.67 (3H, m), 1.37-1.15 (5H, m).
  • the present compound 45 1 H-NMR (CDCl 3 ) ⁇ : 4.40 (2H, s), 3.34 (2H, dd), 2.57 (3H, s), 2.49 (3H, s), 2.35 (3H, s), 2.05 (3H, s), 1.57 (2H, m), 0.90 (3H, t).
  • Invention compound 46 1 H-NMR (CDCl 3 ) ⁇ : 3.50 to 3.43 (4H, m), 2.79 (2H, m), 2.53 (3H, s), 2.47 (3H, s), 2.36 (3H, s) ), 2.02 (3H, s), 1.19 (3H, t).
  • Invention compound 47 1 H-NMR (CDCl 3 ) ⁇ : 5.43 (1H, m), 5.16 (1H, m), 3.23 (2H, d), 2.48 (3H, s), 2.47 (3H, s), 2.34 (3H, s), 2.19 (2H, m), 2.03 (3H, s), 1.03 (3H, t).
  • the present compound 48 1 H-NMR (CDCl 3 ) ⁇ : 3.34 (2H, s), 2.58 (3H, s), 2.48 (3H, s), 2.39 (3H, s), 2.15-2.07 (2H, m) ), 2.04 (3H, s), 1.07 (3H, t).
  • Invention compound 49 1 H-NMR (CDCl 3 ) ⁇ : 5.53-5.39 (2H, m), 2.52 (3H, s), 2.49 (2H, m), 2.47 (3H, s), 2.36 (3H, s) ), 2.19 (2H, m), 2.03 (3H, s), 1.58 (3H, m).
  • the present compound 50 1 H-NMR (CDCl 3 ) ⁇ : 5.82 (1H, m), 5.09-4.99 (2H, m), 2.49 (3H, s), 2.49-2.42 (2H, m), 2.47 (3H) , s), 2.35 (3H, s), 2.12 (2H, t), 2.02 (3H, s), 1.55 (2H, m).
  • the present compound 51 1 H-NMR (CDCl 3 ) ⁇ : 2.74-2.62 (2H, m), 2.53 (3H, s), 2.47 (3H, s), 2.37 (3H, s), 2.32-2.23 (2H , m), 2.02 (3H, s), 1.77 (3H, t).
  • Invention compound 52 1 H-NMR (CDCl 3 ) ⁇ : 2.65-2.51 (2H, m), 2.51 (3H, s), 2.48 (3H, s), 2.38 (3H, s), 2.03 (3H, s) ), 2.26 (2H, dt), 2.01 (1H, t), 1.72-1.61 (2H, m).
  • the present compound 101 1 H-NMR (CDCl 3 ) ⁇ : 6.36 (0.5 H, d), 6.29 (0.5 H, d), 5.96-5.82 (1 H, m), 2.61-2.52 (2 H, m), 2.51 (1.5 H, s), 2. 49 (1.5 H, s), 2. 49 (1.5 H, s), 2. 40 (1.5 H, s), 2. 38-2. 32 (1 H, m), 2. 33 (1.5 H, s), 2. 27 ( 1.5 H, s), 2.26-2.18 (1 H, m), 2.08 (1.5 H, s), 2.05 (1.5 H, s).
  • the present compound 102 1 H-NMR (CDCl 3 ) ⁇ : 6.18 (0.5 H, d), 6.08 (0.5 H, d), 5.82-5. 73 (1 H, m), 3.23 (0.5 H, m), 3.15 ( 0.5 H, m), 2.50 (1.5 H, s), 2. 48 (1.5 H, s), 2. 26 (1.5 H, s), 2. 24 (1.5 H, s), 2.22-2.13 (1 H, m), 2.06 (1.5) H, s), 2.04 (1.5 H, s), 1. 88-1.80 (1 H, m), 1.53-1. 43 (1 H, m), 1.41-1. 30 (1 H, m), 1.21 (3 H, d), 1.
  • the present compound compound 123 1 H-NMR (CDCl 3 ) ⁇ : 5.24 (0.5 H, dd), 4.94 (0.5 H, dd), 3.29 (1 H, br s), 3.17 (1 H, s), 2.49 (1.5 H) , s), 2.49 (1.5 H, s), 2. 48 (1.5 H, s), 2. 48 (1.5 H, s), 2. 46 (1.5 H, s), 2. 45 (1.5 H, s), 2. 32 (1.5 H, s) ), 2.30 (1.5 H, s), 2.16 (1 H, m), 2.03 (1.5 H, s), 2.03 (1.5 H, s), 1. 98 (1 H, m), 1.02 (1.5 H, t), 0.89 ( 1.5 H, t).
  • the present compound 53 1 H-NMR (CDCl 3 ) ⁇ : 2.49 (3H, s), 2.48-2.38 (5H, m), 2.35 (3H, s), 2.02 (3H, s), 1.49-1 .20 (16H , m), 0.88 (3H, t).
  • Production Example 8 The compounds produced according to the method described in Production Example 7 and the physical properties thereof are shown below. In the compound represented by the formula (A-3), compounds wherein R 1x and R 2x are any combination of those described in [Table 6].
  • the present compound 54 1 H-NMR (CDCl 3 ) ⁇ : 2.49 (3H, s), 2.47 (3H, s), 2.46-2.40 (2H, m), 2.35 (3H, s), 2.02 (3H, s) ), 1.49-1.39 (2H, m), 1.39-1.22 (8H, m), 0.89 (3H, t).
  • the present compound 55 1 H-NMR (CDCl 3 ) ⁇ : 2.49 (3H, s), 2.46 (3H, s), 2.46-2.40 (2H, m), 2.35 (3H, s), 2.02 (3H, s) ), 1.48-1.27 (8H, m), 0.89 (3H, t).
  • the present compound 56 1 H-NMR (CDCl 3 ) ⁇ : 2.49 (3H, s), 2.47 (3H, s), 2.54-2.38 (2H, m), 2.35 (3H, s), 2.02 (3H, s) ), 1.40-1.51 (2H, m), 1.39-1 .28 (4H, m), 0.91 (3H, t).
  • the present compound 57 1 H-NMR (CDCl 3 ) ⁇ : 2.49 (3H, s), 2.47 (3H, s), 2.48-2.41 (2H, m), 2.36 (3H, s), 2.02 (3H, s) ), 1.47-1.33 (4H, m), 0.94 (3H, t).
  • the present compound 58 1 H-NMR (CDCl 3 ) ⁇ : 2.49 (3H, s), 2.47 (3H, s), 2.46-2.38 (2H, m), 2.36 (3H, s), 2.02 (3H, s) ), 1.54-1.43 (2H, m), 0.97 (3H, t).
  • Invention compound 59 1 H-NMR (CDCl 3 ) ⁇ : 2.50 (3H, s), 2.47 (3H, s), 2.54-2.44 (2H, m), 2.37 (3H, s), 2.03 (3H, s) ), 1.09 (3H, t).
  • the present compound 60 1 H-NMR (CDCl 3 ) ⁇ : 2.50 (3H, s), 2.47 (3H, s), 2.46-2.37 (2H, m), 2.36 (3H, s), 2.03 (3H, s) ), 1.63-1.51 (1 H, m), 1.50-1. 39 (2 H, m), 1.29-1.21 (2 H, m), 0.89 (6 H, d).
  • the present compound 61 1 H-NMR (CDCl 3 ) ⁇ : 2.61-2.51 (2H, m), 2.50 (3H, s), 2.48 (3H, s), 2.36 (3H, s), 2.21-2.06 (2H , m), 2.03 (3H, s), 1.79-1.68 (2H, m).
  • the present compound 62 1 H-NMR (CDCl 3 ) ⁇ : 2.54-2.39 (8H, m), 2.35 (3H, s), 2.02 (3H, s), 1.81-1.62 (5H, m), 1.36-1.19 (6H, m), 1.01-0.88 (2H, m).
  • Invention compound 104 1 H-NMR (CDCl 3 ) ⁇ : 2.60-2.46 (2H, m), 2.50 (3H, s), 2.47 (3H, s), 2.40-2.35 (2H, m), 2.38 (3H , s), 2.02 (3H, s), 1.77-1.59 (4H, m).
  • Invention compound 105 1 H-NMR (CDCl 3 ) ⁇ : 3.18 (1H, m), 2.52-2.37 (2H, m), 2.47 (3H, s), 2.35 (3H, s), 2.00 (3H, s) ), 1.50-1.28 (6H, m), 1.24 (6H, d), 0.91 (3H, t).
  • the present compound 106 1 H-NMR (CDCl 3 ) ⁇ : 3.18 (1H, m), 2.57-2.38 (2H, m), 2.47 (3H, s), 2.35 (3H, s), 2.00 (3H, s) ), 1.50-1.28 (8H, m), 1.24 (6H, d), 0.91 (3H, t).
  • the present compound 107 1 H-NMR (CDCl 3 ) ⁇ : 2.77 (2H, q), 2.56-2.38 (2H, m), 2.48 (3H, s), 2.35 (3H, s), 2.02 (3H, s) ), 1.52-1.32 (6H, m), 1.25 (3H, t), 0.91 (3H, t).
  • Invention compound 108 1 H-NMR (CDCl 3 ) ⁇ : 2.77 (2H, q), 2.58-2.38 (2H, m), 2.48 (3H, s), 2.35 (3H, s), 2.02 (3H, s) ), 1.51-1.26 (8 H, m), 1.25 (3 H, t), 0.90 (3 H, t).
  • Invention compound 109 1 H-NMR (CDCl 3 ) ⁇ : 2.49 (3H, s), 2.47 (3H, s), 2.42-2.26 (2H, m), 2.35 (3H, s), 2.02 (3H, s) ), 1.77-1.57 (5H, m), 1.53-1.39 (1H, m), 1.21-0.92 (5H, m).
  • Invention compound 110 1 H-NMR (CDCl 3 ) ⁇ : 3.19 (1H, m), 2.47 (3H, s), 2.46-2.22 (2H, m), 2.34 (3H, s), 2.02 (3H, s) ), 1.73-1.58 (5H, m), 1.48-1.33 (1H, m), 1.22 (6H, d), 1.20-0.88 (5H, m).
  • the present compound 124 1 H-NMR (CDCl 3 ) ⁇ : 2.49 (3H, s), 2.46 (3H, s), 2.43 (2H, brs), 2.35 (3H, s), 2.02 (3H, s), 1.62 (1 H, m), 1.31 (2 H, m), 0.95 (6 H, d).
  • the present compound 125 1 H-NMR (CDCl 3 ) ⁇ : 2.50 (3H, s), 2.47 (3H, s), 2.47 (1H, m), 2.34 (3H, s), 2.23 (1H, br s) , 2.02 (3H, s), 1.69 (1H, m), 1.46-1.14 (4H, m), 0.89 (3H, t), 0.82 (3H, d).
  • Production Example 10 The compounds produced according to the method described in Production Example 9 and the physical properties thereof are shown below.
  • Formula (A-4) In the compound shown by these, compounds in which R A and R B are any combination of those described in [Table 7].
  • Invention compound 64 1 H-NMR (CDCl 3 ) ⁇ : 3.92 (3H, s), 2.54-2.45 (8H, m), 2.07 (3H, s), 1.50-1.40 (2H, m), 1.39-1.28 (4H, m), 0.90 (3H, t).
  • Invention compound 65 1 H-NMR (CDCl 3 ) ⁇ : 4.42 (2H, s), 3.92 (3H, s), 3.31 (3H, s), 2.57 (3H, s), 2.50 (3H, s), 2.10 (3H, s).
  • the present compound 66 1 H-NMR (CDCl 3 ) ⁇ : 4.47 (2H, s), 3.92 (3H, s), 3.33-3.23 (1H, m), 2.49 (3H, s), 2.58 (3H, s) ), 2.10 (3H, s), 1.96-1.86 (2H, m), 1.78-1.69 (2H, m), 1.58-1.48 (1H, m), 1.36-1.14 (5H, m).
  • the present compound 67 1 H-NMR (CDCl 3 ) ⁇ : 3.93 (3H, s), 2.77-2.71 (8H, m), 2.09 (3H, s), 1.67-1.67 (2H, m), 1.42-1.31 (4H, m), 0.90 (3H, t).
  • Invention compound 115 1 H-NMR (CDCl 3 ) ⁇ : 3.92 (3H, s), 3.20 (1H, m), 2.47 (3H, s), 2.39 (2H, d), 2.06 (3H, s), 1.76-1.56 (5H, m), 1.48-1.33 (1H, m), 1.23 (6H, d), 1.21-1.08 (3H, m), 1.07-0.93 (2H, m).
  • Invention compound 116 1 H-NMR (CDCl 3 ) ⁇ : 3.92 (3H, s), 3.18 (1H, m), 2.52-2.47 (2H, m), 2.47 (3H, s), 2.06 (3H, s) ), 1.49-1.26 (8H, m), 1.24 (6H, d), 0.89 (3H, t).
  • Invention compound 129 1 H-NMR (CDCl 3 ) ⁇ : 7.54-7.51 (2H, m), 7.46-7.37 (3H, m), 5.00 (2H, s), 4.63 (2H, s), 3.33 (1H , m), 2.49 (3H, s), 2.21 (3H, s), 1.30 (6H, d).
  • Invention compound 130 1 H-NMR (CDCl 3 ) ⁇ : 7.41-7.34 (5 H, m), 5.08 (1 H, m), 4. 78 (2 H, s), 3. 36 (2 H, m), 3.04 (1 H, m) ), 2.77 (2H, m), 2.49 (3H, s), 2.46-2.37 (4H, m), 2.21 (3H, s), 1.21 (6H, d).
  • Production Example 17 The compounds produced according to the method described in Production Example 16 and the physical properties thereof are shown below.
  • Formula (A-5) In the compounds shown by these, compounds in which R 3 , R A and R B are any combination of those described in [Table 8].
  • the present compound 72 1 H-NMR (CDCl 3 ) ⁇ : 3.95 (3H, s), 2.53 (6H, s), 2.17 (6H, s).
  • Invention compound 73 1 H-NMR (CDCl 3 ) ⁇ : 7.44-7.35 (5H, m), 4.78 (2H, s), 2.53 (6H, s), 2.21 (6H, s).
  • Invention compound 118 1 H-NMR (CDCl 3 ) ⁇ : 3.94 (3H, s), 3.49-3.20 (1H, m), 2.55-2.49 (2H, m), 2.48 (3H, s), 2.06 (3H) , s), 1.49-1.26 (8H, m), 1.24 (6H, d), 0.90 (3H, t).
  • Invention compound 119 1 H-NMR (CDCl 3 ) ⁇ : 3.46-3.20 (1H, m), 2.66-2.51 (2H, m), 2.16 (3H, s), 1.94 (3H, s), 1.48-1.19 (8H, m), 1.38 (6H, d), 0.88 (3H, t).
  • the present compound 74 1 H-NMR (CDCl 3 ) ⁇ : 7.49-7.30 (5H, m), 5.64 (1H, m), 4.83 (2H, s), 2.47 (3H, s), 2.42 (3H, s) ), 2.36-2.92 (7H, m), 1.78-1.55 (4H, m).
  • Production Example 20 The compounds produced according to the method described in Production Example 19 and the physical properties thereof are shown below.
  • the present compound 75 1 H-NMR (CDCl 3 ) ⁇ : 7.42-7.30 (5H, m), 5.70 (1H, m), 4.78 (2H, s), 2.63-2.56 (2H, m), 2.55-2.48 (2H, m), 2.46 (3H, s), 2.42 (3H, s), 2.15 (3H, s), 2.04-1.94 (2H, m).
  • the present compound 76 1 H-NMR (CDCl 3 ) ⁇ : 7.52-7.32 (5H, m), 4.86 (2H, s), 2.66 (3H, m), 2.51 (3H, s), 2.20 (3H, s) ).
  • Invention compound 77 1 H-NMR (CDCl 3 ) ⁇ : 7.50 to 7.27 (5H, m), 6.44 (1H, d), 5.85 (1H, dd), 4.80 (2H, s), 2.47 (3H, s) ), 2.36-2.24 (2H, m), 2.19 (3H, s), 2.16 (3H, s), 1.54-1.12 (22H, m), 0.88 (3H, t).
  • Production Example 24 The compounds produced according to the method described in Production Example 23 and the physical properties thereof are shown below.
  • Formula (A-6) In the compounds represented by the above, compounds in which R 1x is described in [Table 9].
  • Invention compound 78 1 H-NMR (CDCl 3 ) ⁇ : 7.50 to 7.28 (5H, m), 6.44 (1H, d), 5.88 (1H, dd), 4.79 (2H, s), 2.46 (3H, s) ), 2.25-2.36 (2H, m), 2.19 (3H, s), 2.15 (3H, s), 1.50-1. 14 (12H, m), 0.87 (3H, t).
  • Invention compound 79 1 H-NMR (CDCl 3 ) ⁇ : 7.49-7.31 (5H, m), 6.45 (1H, d), 5.85 (1H, td), 4.80 (2H, s), 2.48 (3H, s) ), 2.34-2.25 (2H, m), 2.20 (3H, s), 2.16 (3H, s), 1.59-1.38 (2H, m), 0.89 (3H, t).
  • the present compound 80 1 H-NMR (CDCl 3 ) ⁇ : 7.48-7.30 (5H, m), 6.46 (1H, d), 5.85-5. 76 (1H, m), 4.81 (2H, s), 2.50 (3H , s), 2.22 (3H, s), 2.17 (3H, s), 1.52 (3H, d).
  • Production Example 25 The compounds produced according to the method described in Production Example 7 and the physical properties thereof are shown below.
  • Formula (A-7) In the compound shown by these, compounds in which R A and R B are any combination of those described in [Table 10].
  • Invention compound 81 1 H-NMR (CDCl 3 ) ⁇ : 3.91 (1H, s), 2.98 (2H, t), 2.65 (3H, s), 2.25 (3H, s), 2.23 (3H, s), 1.71-1.60 (2H, m), 1.45-1.15 (24H, m), 0.87 (3H, t).
  • Invention compound 82 1 H-NMR (CDCl 3 ) ⁇ : 8.59 (1 H, s), 2.53 (2 H, t), 2. 29 (3 H, s), 2.03 (3 H, s), 2.02 (3 H, s), 1.60-1.50 (2H, m), 1.37-1.18 (14H, m), 0.88 (3H, t).
  • the present compound 83 1 H-NMR (CDCl 3 ) ⁇ : 8.26 (1H, s), 2.52 (2H, t), 2.28 (3H, s), 2.03 (3H, s), 2.02 (3H, s), 1.60-1.52 (2H, m), 1.37-1.26 (4H, m), 0.89 (3H, t).
  • Invention compound 84 1 H-NMR (CDCl 3 ) ⁇ : 2.54 (2H, t), 2.30 (3H, s), 2.06 (3H, s), 2.04 (3H, s), 1.69-1.57 (2H, m) ), 0.97 (3H, t).
  • the compound of the present invention 85 1 H-NMR (CDCl 3 ) ⁇ : 7.85 (1 H, s), 2.85-2.66 (1 H, m), 2.31 (3 H, s), 2.23 (3 H, s), 2.29-2.12 (2 H) , m), 1.98 (3H, s), 1.83-1.74 (2H, m), 1.72-1. 65 (1H, m), 1.53-1.44 (2H, m), 1.38-1.22 (3H, m).
  • Invention compound 86 1 H-NMR (CDCl 3 ) ⁇ : 8.58 (1 H, s), 3.16-3.04 (1 H, m), 2. 32 ( 3 H, s), 2.
  • the present compound 112 1 H-NMR (CDCl 3 ) ⁇ : 8.76 (1H, s), 2.60 (2H, q), 2.54-2.41 (2H, m), 2.28 (3H, s), 2.01 (3H, s) ), 1.52-1.18 (8H, m), 1.24 (3H, t), 0.86 (3H, t).
  • Invention compound 113 1 H-NMR (CDCl 3 ) ⁇ : 3.28 (1 H, m), 2.42 (2 H, d), 2.23 (3 H, s), 2.01 (3 H, s), 1. 74-1. 56 (7 H, m) ), 1.31-0.90 (4H, m), 1.23 (6H, d).
  • Invention compound 114 1 H-NMR (CDCl 3 ) ⁇ : 11.21 (1 H, s), 3.34 (1 H, m), 2.70-2.57 (2 H, m), 2.62 (3 H, s), 2.16 (3 H, s) ), 1.52-1.20 (8H, m), 1.46 (6H, d), 0.87 (3H, t).
  • Invention compound 126 1 H-NMR (CDCl 3 ) ⁇ : 2.49 (2H, m), 2.25 (3H, s), 2.24 (3H, s), 2.01 (3H, s), 1.63 (1H, m), 1.31 (2H, m), 0.94 (6H, d)
  • Invention compound 127 1 H-NMR (CDCl 3 ) ⁇ : 2.50 (1 H, dd), 2.27 (1 H, m), 2.26 (3 H, s), 2.25 (3 H, s), 2.01 (3 H, s), 1.83 (1H, m), 1.44-1.26 (3H, m), 1.14 (1H, m), 0.87 (3H, t), 0.83 (3H, d).
  • Invention compound 128 1 H-NMR (CDCl 3 ) ⁇ : 7.72 (1H, s), 2.52-2.44 (2H, m), 2.26 (3H, s), 2.24 (3H, s), 2.01 (3H, s) ), 1.49-1.16 (16H, m), 0.87 (3H, t).
  • the present compound 132 1 H-NMR (CDCl 3 ) ⁇ : 3.31-3.22 (1H, m), 2.49 (1H, d), 2.42 (1H, d), 2.26 (3H, s), 2.01 (3H, s) ), 1.73-1.60 (4H, m), 1.55-1.22 (6H, m), 1.24 (1.5H, d), 1.23 (1.5H, d), 1.01 (1.5H, m), 0.94 (1.5H, d) ), 0.85 (1.5 H, m), 0.83 (1.5 H, d).
  • Invention compound 133 1 H-NMR (CDCl 3 ) ⁇ : 3.30 (1H, m), 2.52 (1H, d), 2.43 (1H, d), 2.29 (3H, s), 2.02 (3H, s), 1.76-1.69 (2H, m), 1.67-1.61 (2H, m), 1.61-1.54 (3H, m), 1.43-1.35 (2H, m), 1.26-1.22 (6H, m), 1.04-0.90 (2H , m), 0.87 (3H, d), 0.82 (3H, d).
  • the present compound 137 1 H-NMR (CDCl 3 ) ⁇ : 2.48 (2H, m), 2.26 (3H, s), 2.24 (3H, s), 2.01 (3H, s), 1.45-0.36 (3H, m) ), 1.28-1.14 (2H, m), 0.94 (3H, d), 0.87 (3H, t).
  • Invention compound 140 1 H-NMR (CDCl 3 ) ⁇ : 8.19 (1H, s), 4.28 (1H, d), 4.25 (1H, d), 2.32 (3H, s), 2.12 (3H, s), 2.04 (3H, s), 1.34 (3H, t).
  • Invention compound 141 1 H-NMR (CDCl 3 ) ⁇ : 8.33 (1H, s), 4.56 (2H, q), 2.33 (3H, s), 2.14 (3H, s), 2.05 (3H, s).
  • Invention compound 142 1 H-NMR (CDCl 3 ) ⁇ : 8.44 (1 H, s), 8.23 (1 H, s), 4.43 (2 H, t), 2.64-2.47 (2 H, m), 2.33 (3 H, s) ), 2.13 (3H, s), 2.04 (3H, s).
  • Invention compound 143 1 H-NMR (CDCl 3 ) ⁇ : 8.44 (1H, s), 8.22 (1H, s), 4.27 (2H, t), 2.32 (3H, s), 2.31-2.16 (2H, m) ), 2.13 (3H, s), 2.04 (3H, s), 2.04-1.96 (2H, m).
  • Production Example 26 The compounds produced according to the method described in Production Example 5 and the physical properties thereof are shown below.
  • Formula (A-8) In the compound shown by these, compounds in which R A and R B are any combination described in [Table 11].
  • the present compound 88 1 H-NMR (CDCl 3 ) ⁇ : 2.76-2.70 (2H, m), 2.47 (3H, s), 2.36 (3H, s), 2.07 (3H, s), 2.04 (3H, s) ), 1.66-1.56 (2H, m), 1.43-1.20 (24H, m), 0.87 (3H, t).
  • Invention compound 89 1 H-NMR (CDCl 3 ) ⁇ : 2.76-2.70 (2H, m), 2.47 (3H, s), 2.36 (3H, s), 2.07 (3H, s), 2.04 (3H, s) ), 1.67-1.57 (2H, m), 1.43-1.12 (14H, m), 0.88 (3H, t).
  • the present compound 90 1 H-NMR (CDCl 3 ) ⁇ : 2.76-2.70 (2H, m), 2.47 (3H, s), 2.36 (3H, s), 2.07 (3H, s), 2.04 (3H, s) ), 1.67-1.58 (2H, m), 1.42-1.29 (4H, m), 0.89 (3H, t).
  • the present compound 91 1 H-NMR (CDCl 3 ) ⁇ : 2.75-2.69 (2H, m), 2.47 (3H, s), 2.36 (3H, s), 2.07 (3H, s), 2.04 (3H, s) ), 1.73-1.61 (2H, m), 0.99 (3H, t).
  • Invention compound 92 1 H-NMR (CDCl 3 ) ⁇ : 2.81-2.70 (1H, m), 2.56 (3H, s), 2.45 (3H, s), 2.37 (3H, s), 1.98 (3H, s) ), 1.93-1.15 (10H, m).
  • the present compound 93 1 H-NMR (CDCl 3 ) ⁇ : 3.25-3.15 (1H, m), 2.54 (3H, s), 2.46 (3H, s), 2.35 (3H, s), 1.99 (3H, s) ), 1.96-1.62 (8H, m).
  • the present compound 94 1 H-NMR (CDCl 3 ) ⁇ : 2.66 (3H, q), 2.54 (3H, s), 2.35 (3H, s), 2.07 (3H, s).
  • the present compound 134 1 H-NMR (CDCl 3 ) ⁇ : 3.18 (1H, m), 2.53-2.42 (2H, m), 2.49 (3H, s), 2.42-2.34 (2H, m), 2.35 (3H) , s), 2.32-22.23 (2H, m), 2.04-2.95 (2H, m), 2.01 (3H, s), 1.89 (1H, m), 1.54-1.42 (2H, m), 1.25 (6H, d) ).
  • Invention compound 135 1 H-NMR (CDCl 3 ) ⁇ : 3.24-3.13 (1H, m), 2.47 (1.5 H, s), 2.47 (1.5 H, s), 2.43-2.30 (2 H, m), 2.35 (1.5H, s), 2.34 (1.5 H, s), 2.00 (1.5 H, s), 2.00 (1.5 H, s), 1.71-1.62 (3 H, m), 1.58-1.19 (5 H, m), 1.23 (3H, d), 1.22 (3H, d), 1.06-0.96 (1H, m), 0.95 (1.5 H, d), 0.88-0.78 (1 H, m), 0.85 (1.5 H, d).
  • Invention compound 136 1 H-NMR (CDCl 3 ) ⁇ : 3.23-3.13 (1 H, m), 2.50-2.43 (1 H, m), 2.47 (1.5 H, s), 2.47 (1.5 H, s), 2.35 (1.5H, s), 2.34 (1.5 H, s), 2.35-2.29 (1 H, m), 2.02 (1.5 H, s), 2.02 (1.5 H, s), 1.69 (3 H, d), 1.46-1.29 (4H, m), 1.23 (6H, d), 1.10-0.86 (4H, m), 0.89 (3H, d), 0.83 (3H, d).
  • Invention compound 138 1 H-NMR (CDCl 3 ) ⁇ : 2.49 (3H, s), 2.46 (3H, s), 2.48-2.33 (2H, m), 2.35 (3H, s), 2.02 (3H, s) ), 1.47-1.34 (3H, m), 1.30-1. 16 (2H, m), 0.95 (3H, d), 0.89 (3H, t).
  • Invention compound 144 1 H-NMR (CDCl 3 ) ⁇ : 8.32 (1H, s), 4.29 (2H, dd), 2.52 (3H, s), 2.38 (3H, s), 2.26 (3H, s), 2.09 (3H, s), 1.32 (3H, t).
  • Invention compound 145 1 H-NMR (CDCl 3 ) ⁇ : 8.39 (1H, s), 4.56 (2H, q), 2.52 (3H, s), 2.39 (3H, s), 2.27 (3H, s), 2.11 (3H, s).
  • the present compound 146 1 H-NMR (CDCl 3 ) ⁇ : 8.33 (1 H, s), 4.43 (2 H, t), 2.63-2.50 (2 H, m), 2.53 (3 H, s), 2. 39 (3 H, s) ), 2.26 (3H, s), 2.10 (3H, s).
  • the present compound 150 was obtained according to the method described in Reference Production Example 26.
  • the present compound 150 1 H-NMR (CDCl 3 ) ⁇ : 7.58-7.33 (5H, m), 4.79 (2H, s), 3.19 (1H, m), 2.65-2.56 (2H, m), 2.46 (3H , s), 2.19 (3H, s), 1.55-1.15 (8H, m), 1.25 (6H, d), 0.87 (3H, t).
  • the present compound 152 was obtained according to the method described in Reference Production Example 4.
  • the present compound 152 1 H-NMR (CDCl 3 ) ⁇ : 7.51-7.30 (5 H, m), 7.00 (1 H, dd), 6.46 (1 H, dd), 5.42 (1 H, dd), 4.79 (2 H, s ), 3.20 (1H, m), 2.67-2.54 (2H, m), 2.28 (3H, s), 1.59-1.18 (8H, m), 1.28 (6H, d), 0.87 (3H, t).
  • the present compound 154 was obtained according to the method described in Production Example 5.
  • the present compound 154 1 H-NMR (CDCl 3 ) ⁇ : 3.18 (1H, m), 2.76 (2H, q), 2.55-2.38 (2H, m), 2.34 (3H, s), 2.02 (3H, s) ), 1.52-1.18 (8H, m), 1.26 (3H, t), 1.25 (6H, d), 0.89 (3H, t).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is any of the substituents described in [Table A12] to [Table A35]
  • Compounds that are groups hereinafter referred to as compound group SX1).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX2).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX3).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX4.
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX5).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX6.
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX7).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX8.
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX9).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35] Compounds which are any of the substituents described below (hereinafter referred to as compound group SX10).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35] Compounds which are any of the substituents described in (hereinafter referred to as compound group SX11).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX16).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX17).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any substituent as described in following it is hereafter described as compound group SX18).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX19).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX20).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX21).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX22).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX25
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX26).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX27
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX28).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • SX35 The compound which is any one of the substituents as described in the following (hereinafter referred to as compound group SX35).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX36).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is any of the substituents described in [Table A12] to [Table A35]
  • Compounds that are groups (hereinafter referred to as compound group SX37).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX38).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX39).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX40).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX43
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX44).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX45
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX46).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35] ]
  • SX53 The compound which is any one of the substituents as described in the following (hereinafter referred to as compound group SX53).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX54).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX55.
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX56).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX57).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX58).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described hereinafter referred to as compound group SX61).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX62).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX63
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described hereinafter referred to as compound group SX64).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any substituent as described in following is hereafter described as compound group SX71).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX72).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is any of the substituents described in [Table A12] to [Table A35]
  • Compounds that are groups (hereinafter referred to as compound group SX73).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX74).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX75
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described hereinafter referred to as compound group SX76).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX79).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX80).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX81).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX82).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35] Compounds which are any of the substituents described in (hereinafter referred to as compound group SX84).
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX89).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX90).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX91).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX92).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX93).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX94).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX97).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX98).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX99).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX100).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX107).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX108).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is any of the substituents described in [Table A12] to [Table A35]
  • Compounds that are groups (hereinafter referred to as compound group SX109).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX110).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX111).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX112).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX115).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX116).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX117).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX118).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX125).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • the compound which is any substituent as described in following it is hereafter described as compound group SX126).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX127).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX128).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX129).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX130).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX133.
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX134).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX135).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX136).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX143).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX144).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is any of the substituents described in [Table A12] to [Table A35]
  • Compounds that are groups (hereinafter referred to as compound group SX145).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX146).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX147).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX148).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX151).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX152).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX153).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX154).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX161).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX162).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX163
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX164).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX165).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX166).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX169).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX170).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX171.
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX172).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX173).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX179).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX180).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is any of the substituents described in [Table A12] to [Table A35]
  • Compounds that are groups (hereinafter referred to as compound group SX181).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX182).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX183).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX184).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX187).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX188).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX189).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX190).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX193
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35] Compounds which are any of the substituents described in (hereinafter referred to as compound group SX194).
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX197).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • the compound which is any substituent as described in following it is hereafter described as compound group SX198).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX199).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX200).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX201).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX202).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX205.
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX206).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX207).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX208).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX209).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX213).
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX215).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX216).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is any of the substituents described in [Table A12] to [Table A35]
  • Compounds that are groups (hereinafter referred to as compound group SX217).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX218).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX219).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX220).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX223).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX224).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX225.
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX226).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35] Compounds which are any of the substituents described in (hereinafter referred to as compound group SX228).
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX229).
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any substituent as described in following is hereafter described as compound group SX233.
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX234).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX235.
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX236).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX237).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX238).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX239).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX241.
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX242).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX243.
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX244).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX245).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX247).
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX249).
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX251).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • the compound which is any substituent as described in following it is hereafter described as compound group SX252).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is any of the substituents described in [Table A12] to [Table A35]
  • Compounds that are groups hereinafter referred to as compound group SX253
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX254).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX255).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX256).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX257).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX259).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX260).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX261.
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX262).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX263.
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35] Compounds which are any of the substituents described in (hereinafter referred to as compound group SX264).
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX269).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35] ]
  • SX270 The compound which is any one of the substituents as described in the following (hereinafter referred to as compound group SX270).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described hereinafter referred to as compound group SX271.
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX272).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX273
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX274.
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX277).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX278).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX279.
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX280).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX281).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX283.
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX285).
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • the compound which is a substituent in any one of-(It is hereafter described as the compound group SX287).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX288).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is any of the substituents described in [Table A12] to [Table A35]
  • Compounds that are groups (hereinafter referred to as compound group SX289).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX290).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX291.
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX292).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX293
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX295.
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX296).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX297).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX298).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX299).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35] ]
  • SX305 The compound which is any one of the substituents as described in the following (hereinafter referred to as compound group SX305).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX306).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX307).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX308).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX309).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX310).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX311).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX313).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX314).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX315).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX316).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX317).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX319).
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX321).
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX323).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX324).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is any of the substituents described in [Table A12] to [Table A35]
  • Compounds that are groups (hereinafter referred to as compound group SX325).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX326).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX327).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX328).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX329).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX331).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX332).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX333.
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX334).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX335).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35] Compounds which are any of the substituents described in (hereinafter referred to as compound group SX336).
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX341).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX343
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX344).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX345).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX346).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX347).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX 349).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX350).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX351.
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX352).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX353
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX355
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX357).
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX359).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • SX360 The compound which is any one of the substituents as described in the following (hereinafter referred to as compound group SX360).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is any of the substituents described in [Table A12] to [Table A35]
  • Compounds that are groups (hereinafter referred to as compound group SX361).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX362).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX363
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX364).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX367).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX368).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX369).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX370).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35] Compounds which are any of the substituents described in (hereinafter referred to as compound group SX 374).
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35] ]
  • the compound which is a substituent in any one of-(It is described as compound group SX377 hereafter.).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX378).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX379).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX380).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX381.
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX382).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX383
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX385.
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX386).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX387).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX388).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX391).
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX393
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX395).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX396).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is any of the substituents described in [Table A12] to [Table A35]
  • Compounds that are groups hereinafter referred to as compound group SX397).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX398).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX399).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX400).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX403
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX404).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX405).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX406.
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX409).
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is a methyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R B is an ethyl group
  • R A is [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is a methyl group
  • R A is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX413).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R B is an ethyl group
  • R A is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX414).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX415).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX416).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX417).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX418).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX419).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX421.
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX422).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described below hereinafter referred to as compound group SX423
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds that are any of the substituents described below hereinafter referred to as compound group SX424).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX425).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX427).
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • Compounds which are any of the substituents described in hereinafter referred to as compound group SX429).
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is a methyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • the compound which is a substituent in any one of-(It is hereafter described as compound group SX431).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A is an ethyl group
  • R B is a group represented by [Table A12] to [Table A35] ]
  • the compound which is any one of the substituents as described in the following hereinafter referred to as compound group SX432).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41] Compounds which are combinations (hereinafter referred to as compound group SX433).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX434.
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations of hereinafter referred to as compound group SX435).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds that are combinations hereinafter referred to as compound group SX436).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds that are combinations hereinafter referred to as compound group SX437).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations of hereinafter referred to as compound group SX440).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • a combination of compounds hereinafter referred to as compound group SX441).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX442).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX443.
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations of hereinafter referred to as compound group SX444).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX445).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX446).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations of hereinafter referred to as compound group SX447).
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41] Or a combination of compounds (hereinafter referred to as compound group SX450).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds that are combinations hereinafter referred to as compound group SX451.
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX452).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • a compound (hereinafter referred to as a compound group SX453) which is a combination of
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX454).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX455).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations of hereinafter referred to as compound group SX456).
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41] Or a combination of compounds (hereinafter referred to as compound group SX459).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX460).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX461).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations of hereinafter referred to as compound group SX462).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX463).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX464).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are a combination of hereinafter referred to as compound group SX465).
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41] Or a combination of compounds (hereinafter referred to as compound group SX468).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX469).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX470).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any one of [Table A36] to [Table A41]
  • Compounds which are combinations of hereinafter referred to as compound group SX471).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX472).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX473
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations of hereinafter referred to as compound group SX474).
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are a combination of hereinafter referred to as compound group SX475).
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • a compound (hereinafter referred to as a compound group SX476) which is a combination of In the compound represented by formula (L-5), R 4 is a cyclopropyl group, R 5 is a cyclopropyl group, and R A and R B are any of those described in [Table A36] to [Table A41] Or a combination of compounds (hereinafter referred to as compound group SX477).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX478).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX479).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations of hereinafter referred to as compound group SX480).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX481).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX482).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations of hereinafter referred to as compound group SX483.
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41] Or a combination of compounds (hereinafter referred to as compound group SX486).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX487).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX488).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are a combination of hereinafter referred to as compound group SX489).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX490).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX491).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations of hereinafter referred to as compound group SX492).
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are a combination of hereinafter, referred to as compound group SX493
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations of hereinafter referred to as compound group SX494).
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41] Or a combination of compounds (hereinafter referred to as compound group SX495).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX496).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX497).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are a combination of hereinafter referred to as compound group SX 498).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX499).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX500).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations of hereinafter referred to as compound group SX501).
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41] Or a combination of compounds (hereinafter referred to as compound group SX504).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX505).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX506).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations of hereinafter referred to as compound group SX507).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX508.
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX509).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations of hereinafter referred to as compound group SX510).
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41] Or a combination of compounds (hereinafter referred to as compound group SX513).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX514).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX515).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations of hereinafter referred to as compound group SX516).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX517).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX518).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations of hereinafter referred to as compound group SX519).
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41] Or a combination of compounds (hereinafter referred to as compound group SX522).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41] Compounds which are combinations (hereinafter referred to as compound group SX523).
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41] Compounds which are combinations (hereinafter referred to as compound group SX524).
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations of hereinafter referred to as compound group SX525).
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX526).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX527).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations of hereinafter referred to as compound group SX528).
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41] Or a combination of compounds (hereinafter referred to as compound group SX531).
  • R 4 is a methyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX532.
  • R 4 is a methyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX533.
  • R 4 is a methyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations of hereinafter referred to as compound group SX534.
  • R 4 is an ethyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX535).
  • R 4 is an ethyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations hereinafter referred to as compound group SX536).
  • R 4 is an ethyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • Compounds which are combinations of hereinafter referred to as compound group SX537).
  • R 4 is a cyclopropyl group
  • R 5 is a methyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • R 4 is a cyclopropyl group
  • R 5 is an ethyl group
  • R A and R B are any of those described in [Table A36] to [Table A41]
  • R 4 is a cyclopropyl group
  • R 5 is a cyclopropyl group
  • R A and R B are any of those described in [Table A36] to [Table A41] Or a combination of compounds (hereinafter referred to as compound group SX540).
  • the compound S of the present invention represents the compounds described in the compound groups SX1 to SX540.
  • Formulation example 1 10 parts of any one of the compound S of the present invention is mixed into a mixture of 35 parts of xylene and 35 parts of DMF, and 14 parts of polyoxyethylene styryl phenyl ether and 6 parts of calcium dodecylbenzene sulfonate are added thereto and mixed. Obtain a formulation.
  • Formulation example 2 4 parts of sodium lauryl sulfate, 2 parts of calcium lignin sulfonate, 20 parts of wet silica and 54 parts of diatomaceous earth are mixed, and further 20 parts of any one of the compound S of the present invention is added and mixed to obtain a preparation.
  • Formulation example 3 To 2 parts of any one compound of the present invention S, 1 part of wet silica, 2 parts of calcium lignin sulfonate, 30 parts of bentonite and 65 parts of kaolin clay are added and mixed. Then, an appropriate amount of water is added to the mixture, and the mixture is further stirred, granulated with a granulator and blow-dried to obtain a preparation.
  • Formulation example 4 1 part of any one of the compound S of the present invention is mixed with an appropriate amount of acetone, 5 parts of wet silica, 0.3 parts of isopropyl acid phosphate and 93.7 parts of kaolin clay are added thereto and thoroughly mixed. Is removed by evaporation to obtain a preparation.
  • Formulation example 5 A formulation is obtained by thoroughly mixing 35 parts of a mixture of polyoxyethylene alkyl ether sulfate ammonium salt and wet silica (weight ratio 1: 1), 20 parts of any one of the compound S of the present invention and 45 parts of water .
  • Formulation Example 6 0.1 part of any one compound of the present invention S is mixed with a mixture of 5 parts of xylene and 5 parts of trichloroethane, and this is mixed with 89.9 parts of kerosene to obtain a preparation.
  • Formulation example 7 10 mg of any one compound of the present invention S is mixed with 0.5 mL of acetone, and this solution is added dropwise to 5 g of solid feed powder for animals (solid feed powder for rearing and breeding CE-2, a product of CLEA Japan, Inc.), Mix evenly. The acetone is then evaporated to dryness to obtain a toxic bait.
  • Formulation Example 8 0.1 parts of any one compound of the present invention S and 49.9 parts of neothiozole (manufactured by Chuo Kasei Co., Ltd.) are put into an aerosol can, fitted with an aerosol valve, filled with 25 parts of dimethyl ether and 25 parts of LPG and shaken. To obtain an oil aerosol by mounting the actuator.
  • Formulation Example 9 0.6 part of any one compound of the present invention S, 0.01 part of 2,6-di-tert-butyl-4-methylphenol, 5 parts of xylene, 3.39 parts of kerosene and 1 part of Reodol (registered trademark) ) A mixture of MO-60 and 50 parts of distilled water is filled into an aerosol container, and a valve is attached, and then 40 parts of LPG is filled through the valve to obtain an aqueous aerosol.
  • Formulation Example 10 0.1 g of any one of the compounds S of the present invention is mixed with 2 mL of propylene glycol and impregnated into a 4.0 cm ⁇ 4.0 cm, 1.2 cm thick ceramic plate to obtain a heated smoking agent.
  • Formulation example 11 Kneading obtained by melt-kneading 5 parts of any one compound of the present invention S and 95 parts of ethylene-methyl methacrylate copolymer (ratio of methyl methacrylate to total weight of copolymer: 10% by weight) The product is extruded from an extrusion molding machine to obtain a rod-shaped molding having a length of 15 cm and a diameter of 3 mm.
  • Formulation example 12 Five parts of any one compound of the present invention S and 95 parts of a soft vinyl chloride resin are melt-kneaded, and the obtained kneaded product is extruded from an extrusion molding machine to obtain a rod-like molding having a length of 15 cm and a diameter of 3 mm.
  • Formulation example 13 100 mg of any one of the compounds S of the present invention, 68.75 mg of lactose, 237.5 mg of corn starch, 43.75 mg of microcrystalline cellulose, 18.75 mg of polyvinylpyrrolidone, 28.75 mg of sodium carboxymethyl starch, and magnesium stearate2. 5 mg is mixed and the resulting mixture is compressed to a suitable size to obtain tablets.
  • Formulation example 14 25 mg of any one of the compound S of the present invention, 60 mg of lactose, 25 mg of corn starch, 6 mg of carmellose calcium, and 5% hydroxypropyl methylcellulose, and mixing the obtained mixture into hard shell gelatin capsules or hydroxypropyl methylcellulose capsules And get capsules.
  • Formulation example 15 100 mg of any one compound of the present invention S, fumaric acid 500 mg, sodium chloride 2000 mg, methyl paraben 150 mg, propyl paraben 50 mg, granular sugar 25000 mg, sorbitol (70% solution) 13000 mg, Veegum K 100 mg, perfume 35 mg, and coloring Distilled water is added to a final volume of 100 mL and mixed to give a suspension for oral administration.
  • Formulation example 16 5% by weight of any one of the compound S of the present invention is mixed with 5% by weight of an emulsifier, 3% by weight of benzyl alcohol and 30% by weight of propylene glycol so that the pH of this solution becomes 6.0 to 6.5. After adding phosphate buffer to the mixture, water is added as the remainder to obtain a solution for oral administration.
  • Formulation example 17 5% by weight of aluminum distearate is added to 57% by weight of fractionated palm oil and 3% by weight of polysorbate 85 and dispersed by heating. It is cooled to room temperature and 25% by weight of saccharin is dispersed in the oily vehicle. To this, 10% by weight of any one compound of the present invention S is distributed to obtain a pasty preparation for oral administration.
  • Formulation example 18 5% by weight of any one of the compounds S of the present invention is mixed with 95% by weight of limestone powder to obtain granules for oral administration using a wet granulation method.
  • Formulation example 19 5 parts of any one compound of the present invention S is mixed with 80 parts of diethylene glycol monoethyl ether, and 15 parts of propylene carbonate is mixed therewith to obtain a spot-on solution.
  • Formulation example 20 Ten parts of any one compound of the present invention S is mixed with 70 parts of diethylene glycol monoethyl ether, and 20 parts of 2-octyldodecanol is mixed therewith to obtain a pour-on liquid agent.
  • Formulation example 21 60 parts of a 42% aqueous solution of triethanolamine lauryl sulfate and 20 parts of propylene glycol are added to 0.5 part of any one compound of the present invention S, and after sufficient stirring until a homogeneous solution is obtained, water 19.5 Add parts and stir well to obtain a shampoo solution of uniform solution.
  • Formulation example 22 0.15% by weight of any one compound of the present invention S, 95% by weight of animal feed, and 4.85% by weight of a mixture consisting of dibasic calcium phosphate, diatomaceous earth, Aerosil (registered trademark), and carbonate (or chalk) Stir well to obtain an animal feed premix.
  • Formulation example 23 7.2 g of any one of the compounds S of the present invention and 92.8 g of FOSCO.RTM. S-55 are mixed at 100.degree. C., poured into a suppository form, and solidified by cooling to obtain a suppository.
  • test examples the efficacy of the present compound X against harmful arthropods is shown by test examples.
  • the test was performed at 25 ° C.
  • Test method 1 A test compound is prepared according to the method described in Preparation Example 5, and water containing 0.03% by volume of Syndyne (registered trademark) is added thereto to prepare a diluted solution containing a predetermined concentration of the test compound. About 30 cotton aphids (all stages) are inoculated to cucumber (Cucumis sativus) seedlings (the second true leaf development stage) planted in a container. One day later, the seedlings are sprayed with the diluted solution at a rate of 10 mL / seedling. After 5 days, the number of surviving insects is examined, and the control value is determined by the following equation.
  • Control value (%) ⁇ 1- (Cb ⁇ Tai) / (Cai ⁇ Tb) ⁇ ⁇ 100
  • Cb Number of tested insects in untreated area
  • Cai Number of surviving insects in survey in untreated area
  • Tb Number of tested insects in treated zone
  • Tai Number of surviving insects in survey in treated area
  • untreated group means It means a zone that performs the same operation as the treatment zone except that the test compound is not used.
  • Test Example 1-1 As a result of conducting a test according to the test method 1 by setting a predetermined concentration to 500 ppm and using the following compound of the present invention as a test compound, each of the following compounds of the present invention showed a control value of 90% or more.
  • the compounds of the invention 1, 2, 3, 5, 6, 7, 8, 9, 12, 13, 14, 15, 17, 18, 21, 22, 24, 25, 27, 28, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 41, 43, 44, 45, 46, 48, 49, 50, 51, 52, 54, 55, 56, 57, 59, 60, 61, 62, 63, 65, 66, 67, 68, 70, 71, 72, 81, 83, 84, 85, 88, 89, 90, 91, 95, 96, 97, 98, 101, 102, 103, 104, 105, 106, 107, 108, 109, 112, 114, 116, 117, 120, 124, 126, 127, 131, 134, 135, 136, 138, 140, 142, 146, 147 and 154
  • Test Example 1-2 As a result of conducting a test according to the test method 1 by setting a predetermined concentration to 200 ppm and using the following compound of the present invention as a test compound, all of the compounds of the present invention described below showed a control value of 90% or more.
  • the present invention compounds 1, 5, 6, 8, 9, 22, 27, 30, 31, 32, 33, 34, 35, 41, 46, 53, 56, 57, 58, 59, 60, 61, 62, 63, 64, 71, 72, 89, 92, 93, 97, 105, 106, 107, 108, 112, 120, 122, 123, 124, 125, 135, 138 and 154
  • Test example 2 The test was conducted according to Test Method 2 using a compound of the present invention described below as a test compound at a predetermined concentration of 500 ppm. As a result, all of the compounds of the present invention described below showed a mortality of 80% or more.
  • the compounds of the present invention 1, 4, 6, 8, 9, 27, 30, 32, 34, 35, 36, 40, 43, 53, 56, 60, 63, 64, 68, 94 and 97
  • Test method 3 A test compound is prepared according to the method described in Preparation Example 5, and water containing 0.03% by volume of Syndyne (registered trademark) is added thereto to prepare a diluted solution containing a predetermined concentration of the test compound.
  • the diluted solution is sprayed at a rate of 20 mL / seedling to cabbage (Brassicae oleracea) seedlings (second to third leaf development stage) planted in a container. After that, the stems and leaves of this seedling are cut and placed in a container covered with filter paper. Release 5 2nd instar larvae to this. After 5 days, the number of living worms is counted, and the mortality rate is calculated from the following equation.
  • Mortality rate% (1-number of surviving insects / 5) x 100
  • Test Example 3 The compound of the present invention described below was used as a test compound and tested according to Test Method 3 with a predetermined concentration of 500 ppm. As a result, all of the compounds of the present invention showed a mortality of 80% or more.
  • the compounds of the present invention 28, 29, 37, 44, 45, 47, 49, 54, 55, 62, 70, 73, 81, 83, 84, 88, 90, 95, 98, 104, 106, 107, 108, 109, 110, 111, 112, 114, 116, 118, 120, 122, 124, 125, 126, 127, 134, 136, 137, 138, 140, 150, 153 and 154
  • Test Example 4 The compound of the present invention described below was used as a test compound and tested according to Test Method 4 at a predetermined concentration of 500 ppm. As a result, all of the compounds of the present invention showed a mortality of 80% or more.
  • Compounds of the present invention 1, 2, 3, 5, 6, 14, 19, 21, 22, 24, 25, 27, 28, 29, 30, 30, 40, 45, 46, 47, 49, 50, 51, 52, 53, 54, 55, 56, 57, 60, 61, 62, 64, 67, 71, 76, 81, 83, 88, 89, 90, 92, 96, 97, 98, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 114, 115, 116, 120, 122, 124, 125, 126, 127, 128, 132, 133, 134, 135, 136, 137, 138, 140, 141, 150, 151, 153 and 154
  • Test Example 5 The compound of the present invention described below was tested as a test compound at a predetermined concentration of 500 ppm, and as a result, each of the compounds of the present invention described below showed a mortality of 90% or more.
  • Compounds of the present invention 27, 28, 29, 37, 46, 48, 52, 53, 54, 55, 56, 60, 61, 62, 64, 67, 84, 89, 91, 92, 93, 102, 103, 105, 106, 107, 108, 109, 110, 115, 116, 122, 124, 125, 135, 136, 138 and 154
  • Test method 6 A test compound is prepared according to the method described in Preparation Example 5, and water containing 0.03% by volume of Syndyne (registered trademark) is added thereto to prepare a diluted solution containing a predetermined concentration of the test compound.
  • Syndyne registered trademark
  • the B. tabaci adults are released and allowed to lay eggs for about 24 hours.
  • the seedlings are stored for 8 days, and larvae are hatched from the delivered eggs.
  • the diluted solution is sprayed onto the seedlings at a rate of 10 mL / seedling. After 7 days, the number of surviving insects is investigated, and the control value is determined by the following equation.
  • Control value (%) ⁇ 1- (Cb ⁇ Tai) / (Cai ⁇ Tb) ⁇ ⁇ 100
  • Cb The number of insects immediately before the treatment in the untreated zone
  • Cai The number of living insects in the survey of the untreated region
  • Tb The number of insects just before the treatment in the treated zone
  • Tai The number of living insects in the survey of the treated region Means a zone which performs the same operation as the treatment zone except that the test compound is not used.
  • Test Example 6 As a result of conducting a test according to the test method 6 by setting a predetermined concentration to 500 ppm and using the following compound of the present invention as a test compound, all of the following compounds of the present invention showed 90% or more of control value.
  • Compounds of the present invention 27, 30, 32, 36, 53, 56, 57, 60, 62, 63, 64, 72, 89, 90, 91, 92, 103, 106, 107, 108, 122, 124, 138, 142 and 154
  • Test Example 7 The compound of the present invention described below exhibited a mortality of 90% or more as a result of conducting a test according to test method 7 using a compound of the present invention described below as a test compound, with a predetermined concentration of 500 ppm.
  • Test method 8 A test compound is prepared according to the method described in Preparation Example 5, and water containing 0.03% by volume of Syndyne (registered trademark) is added thereto to prepare a diluted solution containing a predetermined concentration of the test compound. About 40 adult spider mite mites are released on kidney bean (Phaseolus vulgaris) seedlings (first true leaf development stage) planted in a container. One day later, the seedlings are sprayed with the diluted solution at a rate of 10 mL / seedling. After 7 days, the number of surviving insects is examined, and the control value is calculated by the following equation.
  • Control value (%) ⁇ 1- (Cb ⁇ Tai) / (Cai ⁇ Tb) ⁇ ⁇ 100
  • Cb Number of tested insects in untreated area
  • Cai Number of surviving insects in survey in untreated area
  • Tb Number of tested insects in treated zone
  • Tai Number of surviving insects in survey in treated area
  • untreated group means It means a zone that performs the same operation as the treatment zone except that the test compound is not used.
  • Test Example 8 As a result of conducting a test according to the test method 8 by setting a predetermined concentration to 500 ppm and using the following compound of the present invention as a test compound, the following compound of the present invention showed a control value of 90% or more.
  • Invention compounds 56, 105, 106, 108, 109, 115, 116, 122, 135, 136 and 154
  • Test Example 9 The compound of the present invention described below was used as a test compound and tested according to test method 9 with a predetermined concentration of 3.5 ppm, and all of the compounds of the present invention showed a mortality of 91% or more.
  • Compounds of the present invention 28, 29, 38, 47, 48, 54, 55, 64, 81, 103, 105, 106, 108, 110, 114, 116, 131, 134, 136, 140 and 146
  • Test Example 10 The compound of the present invention described below was used as a test compound and tested according to Test Method 10 with a predetermined concentration of 500 ppm. As a result, all of the compounds of the present invention showed a mortality of 80% or more.
  • the present compounds 27, 28, 29, 30, 31, 32, 33, 34, 36, 40, 43, 47, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 63, 64, 67, 68, 89, 90, 94, 102, 103, 105, 106, 107, 108, 116, 123, 124, 125, 134, 138 and 154
  • Test Example 11 As a result of conducting a test according to the test method 11 by setting a predetermined concentration to 500 ppm and using the following compound of the present invention as a test compound, all of the following compounds of the present invention showed 100% mortality.
  • the compounds of the present invention 29, 31, 33, 34, 47, 49, 50, 54, 55, 56, 57, 58, 59, 60, 63, 67, 68, 91, 94, 96, 125 and 134
  • Test Example 12-1 The test was conducted according to test method 12 using the following compound of the present invention as a test compound, with the predetermined time being set to 1 hour.
  • the present invention compounds 27, 28, 29, 30, 31, 33, 34, 37, 38, 43, 47, 49, 50, 51, 52, 54, 55, 56, 57, 58, 59, 60, 61, 62, 64, 67, 89, 90, 91, 93, 102, 103, 105, 106, 107, 108, 109, 116, 122, 123, 124, 125, 138, 144, 145, 146, 147 and 154
  • Test Example 12-2 As a result of conducting a test according to test method 12 by setting a predetermined time to 1 day and using the following compound of the present invention as a test compound, all of the following compounds of the present invention showed a mortality of 80% or more.
  • the present invention compounds 27, 28, 29, 30, 31, 33, 34, 37, 38, 43, 46, 47, 54, 55, 56, 57, 58, 59, 60, 61, 62, 64, 67, 70, 89, 90, 91, 93, 102, 103, 105, 106, 107, 108, 109, 110, 115, 116, 118, 122, 123, 124, 125, 135, 138, 144, 145, 146, 146, 147 and 154
  • the compound of the present invention X exhibits an excellent control effect on harmful arthropods.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Epidemiology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention fournit un composé possédant un excellent effet de lutte contre les arthropodes nuisibles. Ce composé représenté par la formule (I) [Dans la formule, Ｒ1 et Ｒ2 sont identiques ou différents et représentent un groupe hydrocarbonée à chaîne en Ｃ１－Ｃ１５, ou similaire, Ｒ3 représente un groupe alkyle en Ｃ１－Ｃ３, ou similaire, (alcoxy en Ｃ１－Ｃ３), Ｒ4 représente un groupe alkyle en Ｃ１－Ｃ2, ou similaire, Ｒ5 représente un groupe hydrocarbonée à chaîne en Ｃ１－C4, ou similaire, Ｌ1 représente une liaison simple, ou similaire, Ｌ2 représente une liaison simple, ou similaire, et n représente 0 ou 1.] possède un excellent effet de lutte contre les arthropodes nuisibles.
PCT/JP2018/039843 2017-10-27 2018-10-26 Composé pyridine, et agent de lutte contre les arthropodes nuisibles comprenant celui-ci WO2019083007A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2019550314A JPWO2019083007A1 (ja) 2017-10-27 2018-10-26 ピリジン化合物及びそれを含有する有害節足動物防除剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017-207928 2017-10-27
JP2017207928 2017-10-27

Publications (1)

Publication Number Publication Date
WO2019083007A1 true WO2019083007A1 (fr) 2019-05-02

Family

ID=66246478

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2018/039843 WO2019083007A1 (fr) 2017-10-27 2018-10-26 Composé pyridine, et agent de lutte contre les arthropodes nuisibles comprenant celui-ci

Country Status (2)

Country Link
JP (1) JPWO2019083007A1 (fr)
WO (1) WO2019083007A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012036177A (ja) * 2010-07-16 2012-02-23 Sumitomo Chemical Co Ltd ピリジン化合物およびその有害生物防除用途
WO2015119099A1 (fr) * 2014-02-05 2015-08-13 日本曹達株式会社 Composé de pyridine et son application
WO2015199065A1 (fr) * 2014-06-24 2015-12-30 日本曹達株式会社 Compose pyridine et son utilisation
WO2016039048A1 (fr) * 2014-09-10 2016-03-17 日本曹達株式会社 Composé de pyridine et son utilisation
WO2017155052A1 (fr) * 2016-03-09 2017-09-14 日本曹達株式会社 Composé pyridine et son utilisation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012036177A (ja) * 2010-07-16 2012-02-23 Sumitomo Chemical Co Ltd ピリジン化合物およびその有害生物防除用途
WO2015119099A1 (fr) * 2014-02-05 2015-08-13 日本曹達株式会社 Composé de pyridine et son application
WO2015199065A1 (fr) * 2014-06-24 2015-12-30 日本曹達株式会社 Compose pyridine et son utilisation
WO2016039048A1 (fr) * 2014-09-10 2016-03-17 日本曹達株式会社 Composé de pyridine et son utilisation
WO2017155052A1 (fr) * 2016-03-09 2017-09-14 日本曹達株式会社 Composé pyridine et son utilisation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE CAS 30 November 2012 (2012-11-30), retrieved from STN Database accession no. 1408279-57-1 *

Also Published As

Publication number Publication date
JPWO2019083007A1 (ja) 2020-12-03

Similar Documents

Publication Publication Date Title
JP7274424B2 (ja) 複素環化合物及びそれを含有する有害節足動物防除剤
JP7196097B2 (ja) 複素環化合物及びそれを含有する有害節足動物防除剤
JP7253498B2 (ja) 複素環化合物及びそれを含有する有害節足動物防除剤
WO2020158889A1 (fr) Composé hétérocyclique et composition de lutte contre les arthropodes nuisibles le contenant
WO2019065568A1 (fr) Composé hétérocyclique et agent de lutte contre les arthropodes nuisibles contenant celui-ci
WO2020171077A1 (fr) Composé hétérocyclique et composition de lutte contre les arthropodes nuisibles le contenant
JP7050752B2 (ja) 縮合複素環化合物及びそれを含有する組成物
JP7082978B2 (ja) 複素環化合物及びそれを含有する有害節足動物防除剤
JP2019019116A (ja) 複素環化合物及びそれを含有する有害節足動物防除剤
JP7301042B2 (ja) 複素環化合物及びそれを含有する有害節足動物防除組成物
JP7219717B2 (ja) 複素環化合物及びそれを含有する有害節足動物防除剤
WO2019083008A1 (fr) Composé pyridine, et composition de lutte contre des organismes nuisibles comprenant celui-ci
JP7489564B1 (ja) ２－（５－シクロプロピル－３－（エチルスルホニル）ピリジン－２－イル）－５－（（トリフルオロメチル）スルフィニル）ベンゾ［ｄ］オキサゾールの結晶
JP7489565B1 (ja) ２－（５－シクロプロピル－３－（エチルスルホニル）ピリジン－２－イル）－５－（（トリフルオロメチル）スルホニル）ベンゾ［ｄ］オキサゾールの結晶
JP7428693B2 (ja) エーテル化合物及びそれを含有する有害節足動物防除組成物
WO2019083007A1 (fr) Composé pyridine, et agent de lutte contre les arthropodes nuisibles comprenant celui-ci
WO2019208598A1 (fr) Composé de pyrimidine et composition de lutte contre les arthropodes nuisibles le contenant
WO2019208599A1 (fr) Composé de pyrimidine et composition de lutte contre les arthropodes nuisibles le contenant
WO2024080330A1 (fr) Composé de sulfonamide et composition de lutte contre les arthropodes nuisibles le contenant
JP2021006508A (ja) 複素環化合物及びそれを含有する有害節足動物防除剤

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18870308

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2019550314

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18870308

Country of ref document: EP

Kind code of ref document: A1