WO2019071658A1 - Traditional chinese medicine composition treating pulmonary disease, preparation method and application - Google Patents
Traditional chinese medicine composition treating pulmonary disease, preparation method and application Download PDFInfo
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- WO2019071658A1 WO2019071658A1 PCT/CN2017/108300 CN2017108300W WO2019071658A1 WO 2019071658 A1 WO2019071658 A1 WO 2019071658A1 CN 2017108300 W CN2017108300 W CN 2017108300W WO 2019071658 A1 WO2019071658 A1 WO 2019071658A1
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- chinese medicine
- traditional chinese
- medicine composition
- dried
- wild rose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Definitions
- the invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating lung diseases, a preparation process and application thereof.
- Pulmonary effusion, emphysema, pulmonary calcification, pulmonary fibrosis, lung cancer and other lung diseases are common and frequently-occurring diseases that threaten human health, and all ages have the possibility of disease, which has brought great benefits to human beings. Pain, a serious threat to human health. Among them, pulmonary effusion is one of the most serious causes of mortality in lung diseases. At present, there is no specific treatment for effusion. Therefore, the problem of pulmonary effusion has become a major problem in medical science in the world today.
- the causes of pulmonary effusion usually include the following: 1) effusion caused by environmental and air pollution caused by tuberculosis; 2) septic infection caused by virus invasion; 3) product caused by inflammation and sputum control Liquid; 4) necrosis caused by cancer, resulting in effusion; 5) effusion caused by emphysema.
- the root cause is that virus erosion or cell necrosis caused by Pseudomonas aeruginosa causes water in the blood to penetrate into the interstitial space and affect the function of lung ventilation.
- the technical problem to be solved by the present invention is to provide a therapeutic drug, a preparation process and an application thereof which are excellent in curative effect.
- the technical solution adopted by the present invention is: A traditional Chinese medicine composition for treating lung diseases, including wild rose.
- the beneficial effects of the invention are as follows: the use of wild rose can activate the function of human cell repair factor and anti-virus, and utilizes the self-immune function of the human body to not only achieve anti-treatment of lung diseases such as Agrobacterium tumefaciens, but also to cause The repair of necrotic cells caused by the disease makes the treatment more thorough and reduces the risk of recurrence, and can be applied to the repair drugs in the treatment of various lung diseases.
- Wild rose is cheap and easy to obtain, and it is a natural medicine. It has little side effects on the human body. It has no side effects on the human body, no side effects on other drugs, and can be well matched with other drugs.
- the present invention further includes a preparation process of the above traditional Chinese medicine composition for treating lung diseases, comprising the following steps: [1011] S10, picking wild rose leaves in 12 small pots for juice extraction, and obtaining after juicing Juice at minus 45
- the preparation process parameters are scientific and reasonable.
- the preparation process is physical processing, no chemical additives, and the active ingredients in natural medicines are retained to the greatest extent, avoiding the toxic side effects of chemical agents on the human body.
- the impurity content is low, and the powder is easily absorbed. All components are made into a powder by drying after being juiced, the impurity content is low, and the powder is more easily absorbed by the human body.
- the present invention also encompasses the use of the above-described traditional Chinese medicine composition for treating lung diseases in the preparation of a medicament for treating pulmonary effusion, emphysema, pulmonary calcification, pulmonary fibrosis, lung cancer or lung repair.
- the beneficial effects of the present invention are as follows: 1) cutting pathology, treating both the symptoms and the root causes.
- the root cause of pulmonary effusion is virus erosion or Pseudomonas aeruginosa infection.
- the present invention fully complies with the genus of the traditional Chinese medicine component itself; in the treatment of emphysema, pulmonary calcification, pulmonary fibrosis and lung cancer, reducing lung accumulation
- the liquid can greatly accelerate the healing of other diseases, and thus achieve both the symptoms and the root causes.
- the toxic and side effects are small and the scope of application is wide.
- the drug has small side effects on the human body and can be widely used as an auxiliary treatment component for other emphysema, pulmonary calcification, pulmonary fibrosis, and lung cancer drugs, and can also be used for repairing drugs in various lung disease treatment drugs, and drug side effects. Small, no side effects on the efficacy of other pharmaceutical ingredients.
- FIG. 1 is a schematic view showing a process flow for preparing a traditional Chinese medicine composition for treating lung effusion according to Examples 1 to 5 of the present invention
- FIG. 2 is a schematic view showing the principle of the treatment of a traditional Chinese medicine composition for treating pulmonary effusion according to Examples 1 to 5 of the present invention.
- the disinfection of the virus-controlled effusion can also improve the body's immunity, making the treatment more thorough and reducing the risk of recurrence.
- a traditional Chinese medicine composition for treating lung diseases a traditional Chinese medicine composition for treating lung diseases, including wild rose.
- the mechanism of action of the present invention is: utilizing the antiviral of wild rose and activating the autoimmune repair function of the human body, the homogenization produced by the disinfection virus control effusion can also improve the immunity of the human body, and the therapeutic effect is more thorough.
- the beneficial effects of the present invention are as follows: the use of wild rose can activate the functions of human cell repair factors and anti-virus, and utilizes the self-immune function of the human body to achieve anti-treatment of lung diseases such as Agrobacterium tumefaciens. It can also repair necrotic cells caused by diseases, make the treatment more thorough, reduce the risk of recurrence, and can be applied to the repair drugs in the treatment of various lung diseases. Wild rose is cheap and easy to obtain, and it is a natural medicine. It has little side effects on the human body. It has no side effects on the human body, no side effects on other drugs, and can be well matched with other drugs. [0028] Further, the composition further includes a slab.
- the bar plate has the function of fighting lung bacteria such as Agrobacterium tumefaciens, and has the function of dehumidification. Therefore, the use of the bar plate in combination with the wild rose is more conducive to lung accumulation. Liquid control.
- the wild rose has a weight percentage of at least 30%.
- the wild rose is 60 to 85 parts by weight, and the bar is classified into 15 to 40 parts by weight.
- the wild rose is 70 to 75 parts by weight, and the bar is classified into 25 to 30 parts by weight.
- the wild rose is a lyophilized powder obtained by lyophilizing the juice after juicing the wild rose, and the slab is returned to the whole filtrate and filtered by the filtrate at 50°. Air-dried powder obtained after air drying under C and the following conditions.
- the wild rose is a wild rose which is the result of the unfinished flower.
- the bar is returned to the whole grass and cooked at 85 ⁇ 95 ° C for l ⁇ 1.5h.
- the bar is returned to the whole grass as a dry bar.
- the slab is returned to the whole grass as a dry slab directly purchased from a pharmacy.
- the slab is immersed in the water of 95 ⁇ 100 ° C for 6-8 hours before cooking, and then the water after immersion is returned to the whole grass at 85 ⁇ 95°. C cook for l ⁇ 1.5h.
- the method for preparing the air-dried powder of the slab is: immersing the slab in the water at 95 ⁇ 100 ° C for 6-8 hours, and then returning the soaked water and the slab to the hay After cooking at 85 ⁇ 95 ° C for 1 ⁇ 1.5h, the filtrate is filtered at 45 ⁇ 50 °C until the water content is less than 5%, the paste is obtained, and the obtained paste is then Air drying is carried out at 50 ° C or below.
- the paste is placed in a stainless steel pan and then air-dried in an air-dried box at 50 ° C or below.
- the thickness of the paste shall not exceed 1.2 cm.
- the present invention has the beneficial effects of: maximally retaining the active ingredients of the wild rose and the bar, and improving the effectiveness of the composition.
- the preparation form of the traditional Chinese medicine composition for treating lung diseases is a capsule, a pill, a granule, an oral liquid or a tablet.
- the preparation form of the traditional Chinese medicine composition for treating lung diseases is a granule.
- the beneficial effects of the present invention are: the preparation of the drug into a form of a granule is more convenient The patient is carried or taken, and the effect after taking it is also better.
- a preparation process for preparing a traditional Chinese medicine composition for treating lung diseases comprising the following steps:
- the preparation process parameters are scientific and reasonable.
- the preparation process is physical processing, no chemical additives, and the active ingredients in natural medicines are retained to the greatest extent, avoiding the toxic side effects of chemical agents on the human body.
- the impurity content is low, and the powder is easily absorbed. All components are made into a powder by drying after being juiced, the impurity content is low, and the powder is more easily absorbed by the human body.
- the preparation process further includes the following steps:
- the preparation process further includes the following steps:
- step S30 further comprises granulating the prepared traditional Chinese medicine composition into a granule package for use.
- the wild rose belongs to the family Rosaceae, and the scientific name is Rosa multiflora, which has the functions of enhancing immunity, anti-virus, anti-tumor, anti-radiation, anti-oxidation and cell repair function, analgesic, detoxification and detoxification. , cure pain, acne and diarrhea and other effects.
- the bar is attributed to Polygonaceae and has therapeutic pain, erysipelas, mastitis, ear-moth moth, cold fever, lung heat cough, whooping cough, malaria
- a preparation process for preparing a traditional Chinese medicine composition for treating lung diseases comprises the following steps:
- the bar is returned to the hay first soaked in water of 95 ⁇ 100 °C for 6 ⁇ 8 hours, and then the soaked water and the bar are returned to the hay to cook at 85 ⁇ 95 °C for l ⁇ 1.5h.
- the obtained filtrate is evaporated at 45 to 50 ° C until the water content is less than 5%, a paste is obtained, and the obtained paste is air-dried at 50 ° C or lower; more preferably Ground, the thickness of the paste does not exceed 1.2 cm;
- step S30 further comprises granulating the prepared traditional Chinese medicine composition into a granule package for use.
- the beneficial effects of the invention are as follows: 1) The preparation process parameters are scientific and reasonable. The preparation process is physical processing, no chemical additives, to maximize the retention of active ingredients in natural medicines, to avoid the toxic side effects of chemical agents on the human body. 2) The preparation process is simple and easy to operate. No harsh conditions, simple operation steps, easy to promote production and use. 3) Low impurity content, easy to absorb in powder form. All components are prepared by powdering and drying to form a powder, which has a low impurity content and is more easily absorbed by the human body. 4) The raw materials are cheap and easy to obtain, and the manufacturing cost is low. Wild rose and bar are all common medicinal materials, cheap and easy to obtain, and low in manufacturing cost.
- the present invention also encompasses the use of the above-described traditional Chinese medicine composition for treating lung diseases in the preparation of a medicament for treating pulmonary effusion, emphysema, pulmonary calcification, pulmonary fibrosis, lung cancer or lung repair.
- the beneficial effects of the present invention are as follows: 1) cutting pathology, treating both the symptoms and the root causes.
- the root cause of the production of pulmonary effusion is virus erosion or Pseudomonas aeruginosa.
- the invention fully complies with the genus of each traditional Chinese medicine component and rationally designs the weight parts of each component, and the obtained medicine can be realized within 3-7 days. Pulmonary effusion decreased significantly, 8-30 days all disappeared; in the treatment of emphysema, pulmonary calcification, pulmonary fibrosis and lung cancer, reducing lung effusion can greatly accelerate the healing of other diseases, and thus achieve both the symptoms and root causes. 2)
- the toxic and side effects are small and the scope of application is wide.
- All components are natural drugs, have little toxic side effects, can be widely used in other emphysema, pulmonary calcification, pulmonary fibrosis, lung cancer drugs, and can be used in various lung disease treatments. Repair The compound drug has a small side effect and has no side effects on the efficacy of other drug ingredients.
- Embodiment 1 of the present invention is:
- a traditional Chinese medicine composition for treating lung diseases comprising the following components: wild rose 600g and bar plate 400g, the preparation process is as follows:
- Example 2 is a traditional Chinese medicine composition for treating lung diseases, which is composed of the following components: wild rose 800g and bar plate 200g, the preparation process is as follows:
- the dried bar plate purchased from the pharmacy is cleaned and removed from the whole grass, and then immersed in water at 100 ° C for 6 hours, and then the water and the plate after soaking are returned to the whole grass and cooked at 95 ° C.
- the filtrate obtained by the steaming after evaporation is evaporated to a paste having a water content of less than 5% at 45-50 ° C, and the obtained paste is placed in a stainless steel pan and placed at 50 ° C or below. Drying in the air-drying box to prepare the air-dried powder for use, wherein the thickness of the paste does not exceed 1.2 cm;
- Example 3 is a traditional Chinese medicine composition for treating lung diseases, which is composed of the following components: wild rose 700g and bar plate According to 300g, the preparation process is as follows:
- Example 4 is a traditional Chinese medicine composition for treating lung diseases, which is composed of the following components: 750 g of wild rose and 250 g of bar plate, and the preparation process is as follows:
- Example 5 is a traditional Chinese medicine composition for treating lung diseases, which is composed of the following components: wild rose lyophilized powder 700 g and slab-dried air-dried powder 300 g, and the preparation process is as follows:
- Example 6 1000 g of pure wild rose lyophilized powder was taken as a granule.
- Example 7 taking 35 ° C air-dried to obtain a pure bar plate air-dried powder 100 g of powder into a powder.
- Example 8 Take the wild lyophilized powder 300g and air-dried at 35 ° C to prepare a slab-dried air-dried powder of 700 g to prepare a granule.
- Case 1 Xu, male, 85 years old, from Zhugen Village, Caofang Township, Ninghua County, hospital diagnosed lung cancer. Symptoms: Pulmonary effusion pain, 12 days without stool, hospital treatment December, the hospital gave up treatment. Taking the product of the first embodiment of the present invention, the pain of the 72 small sputum disappeared, the drainage of the pulmonary effusion was not discharged, and the drug was removed for 10 days, and the effusion disappeared.
- Case 2 Yu Mou, male, 85 years old, Shanghai Hospital diagnosed tuberculosis. Symptoms: Pulmonary effusion causes difficulty in breathing, edema of the legs, taking the product of Example 6 of the present invention, and after 60 days, the remaining 60% of the pulmonary effusion is examined, and after 30 days, 10% remains of the effusion.
- Case 3 Jiang, male, 83 years old, Longyan, Fujian.
- Symptoms Pulmonary effusion is very painful. After taking the product of Example 7 of the present invention, the remaining 70% of the lung effusion is checked after 10 days, and 40% of the effusion remains after 30 days.
- Case 4 Zhou, male, 80 years old, from Quanzhou, Fujian. The hospital diagnosed emphysema. Symptoms: Pulmonary effusion causes chest pain. After taking the product of Example 8 of the present invention, the remaining 50% of the pulmonary effusion is examined 10 days later, and 5% of the effusion remains after 30 days.
- Case 5 Zeng, female, 76 years old, from Sanming City, Fujian province, tuberculosis, pulmonary effusion, critical illness notice. Symptoms: Pulmonary effusion caused severe chest pain. After taking the product of Example 1, the effusion disappeared after 8 days, and the symptoms of pulmonary tuberculosis were significantly relieved 10 days later.
- Pulmonary effusion causes severe chest pain, taking the product of Example 2, checking the disappearance of effusion in 15 days, recovery of lung activity 80
- Case 7 Hu, female, 38 years old, from Youxi County, Sanming, Fujian province, cancer tumor has metastasized to the head, taking the product of Example 3, 15 days to check the disappearance of effusion, the tumor cell diffusion area is small; 30 days later Check tumor cell base There is no proliferation.
- Case 8 Lai, Shanghai, female, 45 years old, advanced lung cancer, severe pulmonary effusion leading to chest pain, taking the product of Example 5, 12 days to check the effusion disappeared, lung cancer cell diffusion area is small; 40 days later The lung cancer cells were found to be substantially non-proliferative.
- Case 9 Liu, Fujian Sanming, male 75 years old, emphysema, taking the example 1 product, 24 hours of effective, 15 days of examination improved significantly, 30 days of cure.
- Case 11 Li, Shanghai, male, 25 years old, lung calcification, lung function is only 40 parts by weight, after taking the product of Example 1, 5 days can walk for one kilometer without rest, the original 50m need to take a break.
- the present invention provides a traditional Chinese medicine composition for treating lung diseases, a preparation process and a use thereof, which have the advantages of effectively controlling the production of effusion and treating lung diseases significantly.
- the traditional Chinese medicine composition has: 1) The formula science is reasonable and the curative effect is remarkable. The root cause of the production of pulmonary effusion is virus erosion or Pseudomonas aeruginosa.
- the present invention makes full use of the self-efficiency of the traditional Chinese medicine component to rationally design the weight parts of each component, so that the traditional Chinese medicine composition can maximize the virus and Anti-Green Agrobacterium is used for anti-treatment, to eliminate viruses and Agrobacterium tumefaciens, and to control the production of effusion. 2) The cure is short, and the lung vitality is restored.
- the pulmonary effusion can be significantly reduced within 3-7 days, and can be completely disappeared within 8 days, and the lung vitality after the treatment by the traditional Chinese medicine composition of the present invention is recovered.
- Treatment and repair, treatment is more thorough.
- the invention utilizes the wild rose and has the effects of enhancing immunity and cell repair, and can repair the necrotic cells caused by the disease in the treatment of the same sputum, so that the treatment effect is more thorough and the risk of recurrence is reduced.
- the toxic and side effects are small and the scope of application is wide.
- All components are natural drugs, and have little toxic side effects to human body; the present invention has obvious effects on pulmonary effusion caused by various factors, and can be widely used for other emphysema, pulmonary calcification, pulmonary fibrosis, lung cancer.
- the auxiliary therapeutic component of the medicine and can be used for repairing drugs in the treatment of various lung diseases, has little toxic and side effects, and has no side effects on the efficacy of other pharmaceutical ingredients.
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Abstract
Provided are a traditional Chinese medicine composition treating pulmonary disease, a preparation method and an application, comprising multiflora rose and perfoliate knotweed. The traditional Chinese medicine composition is prepared by means of the following method: pressing juice from fresh multiflora rose leaves within 12 hours of being picked, and freeze-drying the expressed juice at a temperature of 45°C-25°C below zero, making freeze-dried multiflora rose powder; steaming perfoliate knotweed, and air drying obtained liquid at 50°C or below, making air-dried perfoliate knotweed powder; mixing the freeze-dried multiflora rose powder and the air-dried perfoliate knotweed powder, obtaining a traditional Chinese medicine composition. The present drug may be used in the preparation of a drug used to treat pleural effusion, emphysema, pulmonary calcification, pulmonary fibrosis or lung cancer, or used for lung recovery. Relative to the prior art, the present product has a short curing time and good recovery of lung activity; using the present solution can significantly reduce plural effusion within 3-7 days, can fully eliminate it within eight days, and lung activity recovery is good.
Description
一种治疗肺病的中药组合物、 制备工艺及应用 技术领域 Traditional Chinese medicine composition for treating lung disease, preparation process and application thereof
[0001] 本发明属于中药技术领域, 具体涉及一种治疗肺病的中药组合物、 制备工艺及 应用。 [0001] The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating lung diseases, a preparation process and application thereof.
背景技术 Background technique
[0002] 肺积液、 肺气肿、 肺钙化、 肺纤维化、 肺癌等肺病是严重威胁人类健康的常发 病、 多发病, 且各年齢都有发病的可能, 给人类带来了极大的痛苦, 严重威胁 着人类的健康。 其中, 肺积液是肺病中死亡率最高的一种原因, 目前尚未有专 门治疗积液的特效药, 因此肺积液问题已成为当今世界医学的一大难题。 肺积 液产生的原因通常包括以下几种: 1) 环境、 空气污染产生的肺结核引起的积液 ; 2) 病毒入侵产生的化脓性感染积液; 3) 炎症未得到及吋控制而产生的积液 ; 4) 癌症产生的坏死, 导致的病变积液; 5) 肺气肿产生的积液。 而究其根本 原因是病毒侵蚀或绿脓杆菌引起的细胞坏死导致血液中的水渗入组织间隙中而 影响肺部换气功能。 [0002] Pulmonary effusion, emphysema, pulmonary calcification, pulmonary fibrosis, lung cancer and other lung diseases are common and frequently-occurring diseases that threaten human health, and all ages have the possibility of disease, which has brought great benefits to human beings. Pain, a serious threat to human health. Among them, pulmonary effusion is one of the most serious causes of mortality in lung diseases. At present, there is no specific treatment for effusion. Therefore, the problem of pulmonary effusion has become a major problem in medical science in the world today. The causes of pulmonary effusion usually include the following: 1) effusion caused by environmental and air pollution caused by tuberculosis; 2) septic infection caused by virus invasion; 3) product caused by inflammation and sputum control Liquid; 4) necrosis caused by cancer, resulting in effusion; 5) effusion caused by emphysema. The root cause is that virus erosion or cell necrosis caused by Pseudomonas aeruginosa causes water in the blood to penetrate into the interstitial space and affect the function of lung ventilation.
[0003] 传统肺积液的治疗通常采用导流法、 服用大量使用抗生素或利尿剂增进钠和水 的排泄, 这些方法虽然能暂吋缓解积液症状, 但并不能控制积液的产生, 只能 作为应激手段, 不能从根本上解决肺积液问题。 尤其对于病毒引发的肺积液, 抗生素使用一段吋间后, 会因病毒产生了与抗生素相对应的抗体而导致抗生素 完全失效。 [0003] Traditional pulmonary effusion treatment usually uses diversion method, taking a large amount of antibiotics or diuretics to promote the excretion of sodium and water. Although these methods can temporarily relieve the symptoms of effusion, they cannot control the production of effusion. Can be used as a means of stress, and can not fundamentally solve the problem of pulmonary effusion. Especially for the lung-induced lung effusion, after the antibiotic is used for a period of time, the antibiotic is completely ineffective due to the virus producing antibodies corresponding to the antibiotic.
[0004] 此外, 针对肺纤维化、 肺钙化、 肺气肿、 肺癌等病症, 医学界也尚未发现有能 够治疗的药物, 即使能具有初期的疗效, 对于后期的肺修复也未有治疗药物面 世。 [0004] In addition, for the lung fibrosis, pulmonary calcification, emphysema, lung cancer and other diseases, the medical profession has not found a drug that can be treated, even if it has an initial effect, there is no therapeutic drug for the later lung repair. .
技术问题 technical problem
[0005] 本发明所要解决的技术问题是: 提供一种疗效极佳的肺病治疗药物、 制备工艺 及其应用。 [0005] The technical problem to be solved by the present invention is to provide a therapeutic drug, a preparation process and an application thereof which are excellent in curative effect.
[0006] 技术解决方案与有益效果
[0007] 为了解决上述技术问题, 本发明采用的技术方案为: 一种治疗肺病的中药组合 物, 包括野蔷薇。 [0006] Technical solutions and benefits [0007] In order to solve the above technical problems, the technical solution adopted by the present invention is: A traditional Chinese medicine composition for treating lung diseases, including wild rose.
[0008] 本发明的有益效果在于: 利用野蔷薇能够激活人体细胞修复因子和抗病毒的作 用, 利用人体自有免疫功能, 不仅能实现抗击绿农杆菌等肺病病毒的对抗治疗 , 还能够对因疾病引起的坏死细胞进行修复, 使得治疗效果更彻底, 降低再复 发的风险, 能适用于各种肺病治疗药物治疗过程中的修复药物。 野蔷薇廉价易 得, 且为天然药物, 对人体毒副作用小, 不仅对人体无毒副作用, 对其他药物 也无副作用, 可与其他药物实现良好的配好使用。 [0008] The beneficial effects of the invention are as follows: the use of wild rose can activate the function of human cell repair factor and anti-virus, and utilizes the self-immune function of the human body to not only achieve anti-treatment of lung diseases such as Agrobacterium tumefaciens, but also to cause The repair of necrotic cells caused by the disease makes the treatment more thorough and reduces the risk of recurrence, and can be applied to the repair drugs in the treatment of various lung diseases. Wild rose is cheap and easy to obtain, and it is a natural medicine. It has little side effects on the human body. It has no side effects on the human body, no side effects on other drugs, and can be well matched with other drugs.
[0009] [0009]
[0010] 本发明还包括一种上述治疗肺病的中药组合物的制备工艺, 包括以下步骤: [0011] S10、 取采摘 12小吋内的野蔷薇叶进行榨汁, 并将榨汁后获得的汁液在零下 45 [0010] The present invention further includes a preparation process of the above traditional Chinese medicine composition for treating lung diseases, comprising the following steps: [1011] S10, picking wild rose leaves in 12 small pots for juice extraction, and obtaining after juicing Juice at minus 45
°C~零下 25°C进行冻干, 制成野蔷薇冻干粉。 It is lyophilized at a temperature of minus 25 ° C to form a lyophilized powder of wild rose.
[0012] 本发明的有益效果在于: [0012] The beneficial effects of the present invention are:
[0013] 1) 制备工艺参数科学合理。 制备过程均为物理加工, 无化学添加剂, 最大程 度地保留了天然药物中的有效成分, 避免化学试剂对人体的毒副作用。 [0013] 1) The preparation process parameters are scientific and reasonable. The preparation process is physical processing, no chemical additives, and the active ingredients in natural medicines are retained to the greatest extent, avoiding the toxic side effects of chemical agents on the human body.
[0014] 2) 制备工艺简单, 易操作。 无苛刻条件, 操作步骤简单, 易于推广生产使用 [0014] 2) The preparation process is simple and easy to operate. No harsh conditions, simple operation steps, easy to promote production and use
[0015] 3) 杂质含量低, 粉状易吸收。 所有组分均通过取汁后干燥制成粉末状, 杂质 含量低, 且粉状更易于人体吸收。 [0015] 3) The impurity content is low, and the powder is easily absorbed. All components are made into a powder by drying after being juiced, the impurity content is low, and the powder is more easily absorbed by the human body.
[0016] 4) 原材料廉价易得, 制造成本低廉。 野蔷薇及杠板归均为常见药材, 廉价易 得, 生产制造成本低廉。 [0016] 4) The raw materials are cheap and easy to obtain, and the manufacturing cost is low. Wild rose and bar are all common medicinal materials, cheap and easy to obtain, and low in manufacturing cost.
[0017] [0017]
[0018] 本发明还包括将上述治疗肺病的中药组合物在制备用于治疗肺积液、 肺气肿、 肺钙化、 肺纤维化、 肺癌或肺修复的药物中的应用。 [0018] The present invention also encompasses the use of the above-described traditional Chinese medicine composition for treating lung diseases in the preparation of a medicament for treating pulmonary effusion, emphysema, pulmonary calcification, pulmonary fibrosis, lung cancer or lung repair.
[0019] 本发明的有益效果在于: 1) 切中病理, 标本兼治。 针对肺积液的产生的根本 原因为病毒侵蚀或绿脓杆菌感染, 本发明充分遵循中药组分本身的药属; 在肺 气肿、 肺钙化、 肺纤维化及肺癌治疗过程中, 减少肺积液可大大加速其他病症 的痊愈, 进而实现标本兼治。 2) 毒副作用小, 适用范围广。 所有组分均为天然
药物, 对人体毒副作用小, 能广泛用于其他肺气肿、 肺钙化、 肺纤维化、 肺癌 药物的辅助治疗成分, 还能用于各种肺病治疗药物治疗过程中的修复药物, 药 物毒副作用小, 对其他药物成分的药效无副作用。 [0019] The beneficial effects of the present invention are as follows: 1) cutting pathology, treating both the symptoms and the root causes. The root cause of pulmonary effusion is virus erosion or Pseudomonas aeruginosa infection. The present invention fully complies with the genus of the traditional Chinese medicine component itself; in the treatment of emphysema, pulmonary calcification, pulmonary fibrosis and lung cancer, reducing lung accumulation The liquid can greatly accelerate the healing of other diseases, and thus achieve both the symptoms and the root causes. 2) The toxic and side effects are small and the scope of application is wide. All components are natural The drug has small side effects on the human body and can be widely used as an auxiliary treatment component for other emphysema, pulmonary calcification, pulmonary fibrosis, and lung cancer drugs, and can also be used for repairing drugs in various lung disease treatment drugs, and drug side effects. Small, no side effects on the efficacy of other pharmaceutical ingredients.
[0020] [0020]
[0021] [0021]
问题的解决方案 Problem solution
发明的有益效果 Advantageous effects of the invention
对附图的简要说明 Brief description of the drawing
附图说明 DRAWINGS
[0022] 图 1为本发明实施例 1~5的治疗肺积液的中药组合物制备成冲剂的工艺流程示意 图; 1 is a schematic view showing a process flow for preparing a traditional Chinese medicine composition for treating lung effusion according to Examples 1 to 5 of the present invention; [0022] FIG.
[0023] 图 2为本发明实施例 1~5的治疗肺积液的中药组合物冶疗原理示意图。 2 is a schematic view showing the principle of the treatment of a traditional Chinese medicine composition for treating pulmonary effusion according to Examples 1 to 5 of the present invention.
具体实施方式 Detailed ways
[0024] 本发明最关键的构思在于: 利用野蔷薇的抗病毒和激活人体自身免疫修复功能 [0024] The most critical idea of the present invention is: using the anti-virus of wild rose and activating the body's own immune repair function
, 在消毒病毒控制积液产生的同吋还能提高人体的免疫能力, 使得治疗效果更 彻底, 降低再复发的风险。 The disinfection of the virus-controlled effusion can also improve the body's immunity, making the treatment more thorough and reducing the risk of recurrence.
[0025] 一种治疗肺病的中药组合物, 一种治疗肺病的中药组合物, 包括野蔷薇。 [0025] A traditional Chinese medicine composition for treating lung diseases, a traditional Chinese medicine composition for treating lung diseases, including wild rose.
[0026] 本发明的作用机理为: 利用野蔷薇的抗病毒和激活人体自身免疫修复功能, 在 消毒病毒控制积液产生的同吋还能提高人体的免疫能力, 使得治疗效果更彻底[0026] The mechanism of action of the present invention is: utilizing the antiviral of wild rose and activating the autoimmune repair function of the human body, the homogenization produced by the disinfection virus control effusion can also improve the immunity of the human body, and the therapeutic effect is more thorough.
, 降低再复发的风险。 , reduce the risk of recurrence.
[0027] 从上述描述可知, 本发明的有益效果在于: 利用野蔷薇能够激活人体细胞修复 因子和抗病毒的作用, 利用人体自有免疫功能, 不仅能实现抗击绿农杆菌等肺 病病毒的对抗治疗, 还能够对因疾病引起的坏死细胞进行修复, 使得治疗效果 更彻底, 降低再复发的风险, 能适用于各种肺病治疗药物治疗过程中的修复药 物。 野蔷薇廉价易得, 且为天然药物, 对人体毒副作用小, 不仅对人体无毒副 作用, 对其他药物也无副作用, 可与其他药物实现良好的配好使用。
[0028] 进一步地, 所述组合物还包括杠板归。 [0027] As can be seen from the above description, the beneficial effects of the present invention are as follows: the use of wild rose can activate the functions of human cell repair factors and anti-virus, and utilizes the self-immune function of the human body to achieve anti-treatment of lung diseases such as Agrobacterium tumefaciens. It can also repair necrotic cells caused by diseases, make the treatment more thorough, reduce the risk of recurrence, and can be applied to the repair drugs in the treatment of various lung diseases. Wild rose is cheap and easy to obtain, and it is a natural medicine. It has little side effects on the human body. It has no side effects on the human body, no side effects on other drugs, and can be well matched with other drugs. [0028] Further, the composition further includes a slab.
[0029] 从上述描述可知, 本发明的有益效果在于: 杠板归具有抗击绿农杆菌等肺病细 菌的作用, 还具有除湿的作用, 因此, 将杠板归与野蔷薇配合使用, 更利于肺 积液的控制。 [0029] It can be seen from the above description that the beneficial effects of the present invention are as follows: the bar plate has the function of fighting lung bacteria such as Agrobacterium tumefaciens, and has the function of dehumidification. Therefore, the use of the bar plate in combination with the wild rose is more conducive to lung accumulation. Liquid control.
[0030] 优选地, 所述野蔷薇的重量百分数至少为 30%。 [0030] Preferably, the wild rose has a weight percentage of at least 30%.
[0031] 更优选地, 所述野蔷薇为 60~85重量份, 所述杠板归为 15~40重量份。 More preferably, the wild rose is 60 to 85 parts by weight, and the bar is classified into 15 to 40 parts by weight.
[0032] 优选地, 所述野蔷薇为 70~75重量份, 所述杠板归为 25~30重量份。 [0032] Preferably, the wild rose is 70 to 75 parts by weight, and the bar is classified into 25 to 30 parts by weight.
[0033] 进一步地, 所述野蔷薇为将野蔷薇榨汁后的汁液进行冻干而获得的冻干粉, 所 述杠板归是将杠板归全草经蒸煮过滤后的滤液在 50°C及以下条件下进行风干后制 得的风干粉。 [0033] Further, the wild rose is a lyophilized powder obtained by lyophilizing the juice after juicing the wild rose, and the slab is returned to the whole filtrate and filtered by the filtrate at 50°. Air-dried powder obtained after air drying under C and the following conditions.
[0034] 进一步地, 所述野蔷薇为未幵花结果的野蔷薇。 [0034] Further, the wild rose is a wild rose which is the result of the unfinished flower.
[0035] 进一步地, 所述杠板归全草在 85~95°C下蒸煮 l~1.5h。 [0035] Further, the bar is returned to the whole grass and cooked at 85~95 ° C for l~1.5h.
[0036] 优选地, 所述杠板归全草为干燥的杠板归全草。 [0036] Preferably, the bar is returned to the whole grass as a dry bar.
[0037] 进一步地, 所述杠板归全草为从药店直接购得的干燥的杠板归全草。 [0037] Further, the slab is returned to the whole grass as a dry slab directly purchased from a pharmacy.
[0038] 进一步地, 所述杠板归全草在蒸煮前先在 95~100°C的水中浸泡 6~8小吋, 然后 将浸泡后的水与杠板归全草一同在 85~95°C下蒸煮 l~1.5h。 [0038] Further, the slab is immersed in the water of 95~100 ° C for 6-8 hours before cooking, and then the water after immersion is returned to the whole grass at 85~95°. C cook for l~1.5h.
[0039] 进一步地, 所述杠板归的风干粉的制备方法: 将杠板归干草先在 95~100°C的水 中浸泡 6~8小吋, 然后将浸泡后的水与杠板归干草一同在 85~95°C下蒸煮 l~1.5h后 过滤, 将得到的滤液在 45~50°C下进行蒸发直至含水率低于 5%, 获得糊状物, 再 将得到的糊状物于 50°C及以下的条件下进行风干。 [0039] Further, the method for preparing the air-dried powder of the slab is: immersing the slab in the water at 95~100 ° C for 6-8 hours, and then returning the soaked water and the slab to the hay After cooking at 85~95 ° C for 1~1.5h, the filtrate is filtered at 45~50 °C until the water content is less than 5%, the paste is obtained, and the obtained paste is then Air drying is carried out at 50 ° C or below.
[0040] 进一步地, 将所述糊状物装在不锈钢盘中然后放在 50°C及以下的风干箱中风干[0040] Further, the paste is placed in a stainless steel pan and then air-dried in an air-dried box at 50 ° C or below.
, 其中, 糊状物的厚度不得超过 1.2cm。 , wherein the thickness of the paste shall not exceed 1.2 cm.
[0041] 从上述描述可知, 本发明的有益效果在于: 最大程度保留地野蔷薇和杠板归中 的有效成分, 提升组合物效力。 [0041] As can be seen from the above description, the present invention has the beneficial effects of: maximally retaining the active ingredients of the wild rose and the bar, and improving the effectiveness of the composition.
[0042] 进一步地, 所述治疗肺病的中药组合物的制剂形式为胶囊剂、 丸剂、 冲剂、 口 服液或片剂。 Further, the preparation form of the traditional Chinese medicine composition for treating lung diseases is a capsule, a pill, a granule, an oral liquid or a tablet.
[0043] 优选地, 所述治疗肺病的中药组合物的制剂形式为冲剂。 [0043] Preferably, the preparation form of the traditional Chinese medicine composition for treating lung diseases is a granule.
[0044] 从上述描述可知, 本发明的有益效果在于: 将药物制备成冲剂的形式, 更方便
患者携带或服用, 同吋服用后的疗效也更佳。 [0044] As can be seen from the above description, the beneficial effects of the present invention are: the preparation of the drug into a form of a granule is more convenient The patient is carried or taken, and the effect after taking it is also better.
[0045] 一种制备治疗肺病的中药组合物的制备工艺, 包括以下步骤: [0045] A preparation process for preparing a traditional Chinese medicine composition for treating lung diseases, comprising the following steps:
[0046] S10、 取采摘 12小吋内的野蔷薇叶进行榨汁, 并将榨汁后获得的汁液在零下 45 [0046] S10, picking and picking the wild rose leaves in 12 small pots for juice extraction, and the juice obtained after juicing is below minus 45
°C~零下 25°C下进行冻干, 制成野蔷薇冻干粉。 It is lyophilized at °C~minus at 25°C to prepare wild rose lyophilized powder.
[0047] 本发明的有益效果在于: [0047] The beneficial effects of the present invention are:
[0048] 1) 制备工艺参数科学合理。 制备过程均为物理加工, 无化学添加剂, 最大程 度地保留了天然药物中的有效成分, 避免化学试剂对人体的毒副作用。 [0048] 1) The preparation process parameters are scientific and reasonable. The preparation process is physical processing, no chemical additives, and the active ingredients in natural medicines are retained to the greatest extent, avoiding the toxic side effects of chemical agents on the human body.
[0049] 2) 制备工艺简单, 易操作。 无苛刻条件, 操作步骤简单, 易于推广生产使用 [0049] 2) The preparation process is simple and easy to operate. No harsh conditions, simple operation steps, easy to promote production and use
[0050] 3) 杂质含量低, 粉状易吸收。 所有组分均通过取汁后干燥制成粉末状, 杂质 含量低, 且粉状更易于人体吸收。 [0050] 3) The impurity content is low, and the powder is easily absorbed. All components are made into a powder by drying after being juiced, the impurity content is low, and the powder is more easily absorbed by the human body.
[0051] 4) 原材料廉价易得, 制造成本低廉。 野蔷薇及杠板归均为常见药材, 廉价易 得, 生产制造成本低廉。 [0051] 4) The raw materials are cheap and easy to obtain, and the manufacturing cost is low. Wild rose and bar are all common medicinal materials, cheap and easy to obtain, and low in manufacturing cost.
[0052] [0052]
[0053] 进一步地, 所述制备工艺还包括以下步骤: [0053] Further, the preparation process further includes the following steps:
[0054] S20、 将杠板归进行蒸煮, 将蒸煮过滤后获得的滤液在 50°C以下条件下进行风 干, 制得杠板归风干粉。 [0054] S20, the bar plate is subjected to cooking, and the filtrate obtained by the retort filtration is air-dried under the condition of 50 ° C or lower to obtain a bar-dried air-dried powder.
[0055] 进一步地, 所述制备工艺还包括以下步骤: [0055] Further, the preparation process further includes the following steps:
[0056] S30、 将所述野蔷薇冻干粉和所述杠板归风干粉按 60~85: 15~40的重量比进行 混合, 得到所述中药组合物。 [0056] S30, mixing the wild rose lyophilized powder and the bar-dried air-dried powder according to a weight ratio of 60-85: 15-40, to obtain the traditional Chinese medicine composition.
[0057] 进一步地, 所述步骤 S30还包括将制得的中药组合物制粒, 制成冲剂包装备用 [0057] Further, the step S30 further comprises granulating the prepared traditional Chinese medicine composition into a granule package for use.
[0058] 本发明中, 所述野蔷薇属于蔷薇科 (Rosaceae) , 学名为 Rosa multiflora, 具有 增强免疫力, 抗病毒、 抗肿瘤、 抗辐射、 抗氧化及细胞修复功能、 止痛、 消热 解毒、 治痛疤恶疮及泻下利尿等药效。 所述杠板归属于蓼科 (Polygonaceae) , 具有治疗痛肿、 丹毒、 乳腺炎、 耳喉蛾、 感冒发热、 肺热咳嗽、 百日咳、 疟疾[0058] In the present invention, the wild rose belongs to the family Rosaceae, and the scientific name is Rosa multiflora, which has the functions of enhancing immunity, anti-virus, anti-tumor, anti-radiation, anti-oxidation and cell repair function, analgesic, detoxification and detoxification. , cure pain, acne and diarrhea and other effects. The bar is attributed to Polygonaceae and has therapeutic pain, erysipelas, mastitis, ear-moth moth, cold fever, lung heat cough, whooping cough, malaria
、 风火赤眼、 泄泻、 黄疸、 膨胀水肿、 跌打肿痛、 吐血、 虫蛇咬伤、 瘟疹、 疥 癣、 清热解毒、 利尿消肿等药效。
[0059] , wind and fire red eyes, diarrhea, jaundice, swelling and edema, bruises and swelling, vomiting blood, insect bites, pityriasis, phlegm, heat and detoxification, diuretic swelling and other effects. [0059]
[0060] 优选地, 一种制备治疗肺病的中药组合物的制备工艺, 包括以下步骤: [0060] Preferably, a preparation process for preparing a traditional Chinese medicine composition for treating lung diseases comprises the following steps:
[0061] S10、 取采摘 12小吋内的新鲜野蔷薇叶榨汁, 并将所榨出来的汁在零下 45^~零 下 25°C冻干, 制成野蔷薇冻干粉备用; [0061] S10, picking and extracting fresh wild rose leaf juice in 12 small pots, and lyophilizing the squeezed juice at minus 45^~ below 25 ° C to prepare wild rose lyophilized powder for use;
[0062] S20、 将杠板归干草先在 95~100°C的水中浸泡 6~8小吋, 然后将浸泡后的水与杠 板归干草一同在 85~95°C下蒸煮 l~1.5h后过滤, 将得到的滤液在 45~50°C下进行蒸 发直至含水率低于 5%, 获得糊状物, 再将得到的糊状物于 50°C及以下的条件下 进行风干; 更优选地, 所述糊状物的厚度不超过 1.2cm; [0062] S20, the bar is returned to the hay first soaked in water of 95~100 °C for 6~8 hours, and then the soaked water and the bar are returned to the hay to cook at 85~95 °C for l~1.5h. After filtration, the obtained filtrate is evaporated at 45 to 50 ° C until the water content is less than 5%, a paste is obtained, and the obtained paste is air-dried at 50 ° C or lower; more preferably Ground, the thickness of the paste does not exceed 1.2 cm;
[0063] S30、 将所述野蔷薇冻干粉和所述杠板归风干粉按 60~85: 15~40的重量比混合 得到中药组合物。 [0063] S30, mixing the wild rose lyophilized powder and the bar-dried air-dried powder in a weight ratio of 60-85: 15-40 to obtain a traditional Chinese medicine composition.
[0064] 进一步地, 所述步骤 S30还包括将制得的中药组合物制粒, 制成冲剂包装备用 [0064] Further, the step S30 further comprises granulating the prepared traditional Chinese medicine composition into a granule package for use.
[0065] 本发明的有益效果在于: 1) 制备工艺参数科学合理。 制备过程均为物理加工 , 无化学添加剂, 最大程度地保留了天然药物中的有效成分, 避免化学试剂对 人体的毒副作用。 2) 制备工艺简单, 易操作。 无苛刻条件, 操作步骤简单, 易 于推广生产使用。 3) 杂质含量低, 粉状易吸收。 所有组分均通过取汁后干燥制 成粉末状, 杂质含量低, 且粉状更易于人体吸收。 4) 原材料廉价易得, 制造成 本低廉。 野蔷薇及杠板归均为常见药材, 廉价易得, 生产制造成本低廉。 [0065] The beneficial effects of the invention are as follows: 1) The preparation process parameters are scientific and reasonable. The preparation process is physical processing, no chemical additives, to maximize the retention of active ingredients in natural medicines, to avoid the toxic side effects of chemical agents on the human body. 2) The preparation process is simple and easy to operate. No harsh conditions, simple operation steps, easy to promote production and use. 3) Low impurity content, easy to absorb in powder form. All components are prepared by powdering and drying to form a powder, which has a low impurity content and is more easily absorbed by the human body. 4) The raw materials are cheap and easy to obtain, and the manufacturing cost is low. Wild rose and bar are all common medicinal materials, cheap and easy to obtain, and low in manufacturing cost.
[0066] [0066]
[0067] 本发明还包括将上述治疗肺病的中药组合物在制备用于治疗肺积液、 肺气肿、 肺钙化、 肺纤维化、 肺癌或肺修复的药物中的应用。 The present invention also encompasses the use of the above-described traditional Chinese medicine composition for treating lung diseases in the preparation of a medicament for treating pulmonary effusion, emphysema, pulmonary calcification, pulmonary fibrosis, lung cancer or lung repair.
[0068] 本发明的有益效果在于: 1) 切中病理, 标本兼治。 针对肺积液的产生的根本 原因为病毒侵蚀或绿脓杆菌, 本发明充分遵循各中药组分本身的药属且合理设 计各组分的重量份, 制得的药物可在 3-7天内实现肺积液明显减少, 8-30天全部 消失; 在肺气肿、 肺钙化、 肺纤维化及肺癌治疗过程中, 减少肺积液可大大加 速其他病症的痊愈, 进而实现标本兼治。 2) 毒副作用小, 适用范围广。 所有组 分均为天然药物, 对人体毒副作用小, 能广泛用于其他肺气肿、 肺钙化、 肺纤 维化、 肺癌药物的辅助治疗成分, 还能用于各种肺病治疗药物治疗过程中的修
复药物, 药物毒副作用小, 对其他药物成分的药效无副作用。 [0068] The beneficial effects of the present invention are as follows: 1) cutting pathology, treating both the symptoms and the root causes. The root cause of the production of pulmonary effusion is virus erosion or Pseudomonas aeruginosa. The invention fully complies with the genus of each traditional Chinese medicine component and rationally designs the weight parts of each component, and the obtained medicine can be realized within 3-7 days. Pulmonary effusion decreased significantly, 8-30 days all disappeared; in the treatment of emphysema, pulmonary calcification, pulmonary fibrosis and lung cancer, reducing lung effusion can greatly accelerate the healing of other diseases, and thus achieve both the symptoms and root causes. 2) The toxic and side effects are small and the scope of application is wide. All components are natural drugs, have little toxic side effects, can be widely used in other emphysema, pulmonary calcification, pulmonary fibrosis, lung cancer drugs, and can be used in various lung disease treatments. Repair The compound drug has a small side effect and has no side effects on the efficacy of other drug ingredients.
[0069] [0069]
[0070] 请参照图 1以及图 2, 本发明的实施例 1为: Referring to FIG. 1 and FIG. 2, Embodiment 1 of the present invention is:
[0071] —种治疗肺病的中药组合物, 由以下组分组成: 野蔷薇 600g和杠板归 400g, 其 制备过程如下: [0071] A traditional Chinese medicine composition for treating lung diseases, comprising the following components: wild rose 600g and bar plate 400g, the preparation process is as follows:
[0072] S10、 取采摘 12小吋内的新鲜野蔷薇叶榨汁, 并将榨汁得到的汁液在零下 45°C 冻干, 制成野蔷薇冻干粉备用; [0072] S10, picking and extracting fresh wild rose leaf juice in 12 small pots, and lyophilizing the juice obtained by juicing at minus 45 ° C to prepare a wild rose lyophilized powder for use;
[0073] S20、 将从药店购买到的干燥的杠板归全草清洗除去泥土后, 在 95°C的水中浸 泡 8h, 再将浸泡后的水和杠板归全草一同在 85°C蒸煮 1.5h, 取蒸煮后过滤得到的 滤液在 45~50°C下蒸发至含水率低于 5%的糊状物, 再将得到的糊状物装在不锈钢 盘中并放在 50°C及以下的风干箱中风干制得杠板归风干粉备用, 其中, 所述糊状 的厚度不超过 1.2厘米; [0073] S20, after the dry bar plate purchased from the pharmacy is removed from the whole grass to remove the soil, soaked in water at 95 ° C for 8 hours, and then the soaked water and the bar plate are returned to the whole grass and cooked at 85 ° C. 1.5h, the filtrate obtained by the steaming after evaporation is evaporated to a paste having a moisture content of less than 5% at 45-50 ° C, and the obtained paste is placed in a stainless steel pan and placed at 50 ° C or below. The air-drying box is air-dried to prepare a bar plate to be air-dried powder, wherein the thickness of the paste is not more than 1.2 cm;
[0074] S30、 取野蔷薇冻干粉 600g和所述杠板归风干粉 400g混合得到中药组合物, 将 该中药组合物按常规方法进行制粒, 制成冲剂包装备用。 [0074] S30, taking wild rose lyophilized powder 600g and the bar plate to be dried air powder 400g to obtain a traditional Chinese medicine composition, and granulating the traditional Chinese medicine composition according to a conventional method to prepare a granule for use.
[0075] [0075]
[0076] 实施例 2为一种治疗肺病的中药组合物, 由以下组分组成: 野蔷薇 800g和杠板 归 200g, 其制备过程如下: [0076] Example 2 is a traditional Chinese medicine composition for treating lung diseases, which is composed of the following components: wild rose 800g and bar plate 200g, the preparation process is as follows:
[0077] S10、 取采摘 12小吋内的新鲜野蔷薇叶榨汁, 并将榨汁得到的汁液在零下 25°C 冻干, 制成野蔷薇冻干粉备用; [0077] S10, picking and extracting fresh wild rose leaf juice in 12 small pots, and lyophilizing the juice obtained by juicing at minus 25 ° C to prepare a wild rose lyophilized powder for use;
[0078] S20、 将从药店购买到的干燥的杠板归全草清洗除去泥土后, 在 100°C的水中浸 泡 6h, 再将浸泡后的水和杠板归全草一同在 95°C蒸煮 lh, 取蒸煮后过滤得到的滤 液在 45~50°C下蒸发至含水率低于 5%的糊状物, 再将得到的糊状物装在不锈钢盘 中并放在 50°C及以下的风干箱中风干制得杠板归风干粉备用, 其中, 所述糊状的 厚度不超过 1.2厘米; [0078] S20, the dried bar plate purchased from the pharmacy is cleaned and removed from the whole grass, and then immersed in water at 100 ° C for 6 hours, and then the water and the plate after soaking are returned to the whole grass and cooked at 95 ° C. Lh, the filtrate obtained by the steaming after evaporation is evaporated to a paste having a water content of less than 5% at 45-50 ° C, and the obtained paste is placed in a stainless steel pan and placed at 50 ° C or below. Drying in the air-drying box to prepare the air-dried powder for use, wherein the thickness of the paste does not exceed 1.2 cm;
[0079] S30、 取野蔷薇冻干粉 800g和所述杠板归风干粉 200g混合得到中药组合物, 将 该中药组合物按常规方法进行制粒, 制成片剂包装备用。 [0079] S30, taking wild rose lyophilized powder 800g and the bar plate to be dried air powder 200g to obtain a traditional Chinese medicine composition, and granulating the traditional Chinese medicine composition according to a conventional method to prepare a tablet for use.
[0080] [0080]
[0081] 实施例 3为一种治疗肺病的中药组合物, 由以下组分组成: 野蔷薇 700g和杠板
归 300g, 其制备过程如下: [0081] Example 3 is a traditional Chinese medicine composition for treating lung diseases, which is composed of the following components: wild rose 700g and bar plate According to 300g, the preparation process is as follows:
[0082] S10、 取采摘 12小吋内的新鲜野蔷薇榨汁, 并将榨汁得到的汁液在零下 25°C冻 干, 制成野蔷薇冻干粉备用; [0082] S10, picking and extracting fresh wild rose juice in 12 small pots, and lyophilizing the juice obtained by juicing at minus 25 ° C to prepare a wild rose lyophilized powder for use;
[0083] S20、 将从药店购买到的干燥的杠板归全草蒸煮, 将蒸煮过滤后获得的滤液在 4 o°c条件下进行风干, 制得杠板归风干粉; [0083] S20, the dried bar plate purchased from the pharmacy is returned to the whole grass for cooking, and the filtrate obtained by the retort filtration is air-dried at 4 o °c to obtain a bar-dried air-dried powder;
[0084] S30、 取野蔷薇冻干粉 700g和所述杠板归风干粉 300g混合得到中药组合物, 将 该中药组合物按常规方法制成丸剂包装备用。 [0084] S30, taking wild rose lyophilized powder 700g and the bar plate dry air powder 300g to obtain a traditional Chinese medicine composition, and preparing the traditional Chinese medicine composition into a pill package according to a conventional method.
[0085] [0085]
[0086] 实施例 4为一种治疗肺病的中药组合物, 由以下组分组成: 野蔷薇 750g和杠板 归 250g, 其制备过程如下: [0086] Example 4 is a traditional Chinese medicine composition for treating lung diseases, which is composed of the following components: 750 g of wild rose and 250 g of bar plate, and the preparation process is as follows:
[0087] S10、 取采摘 12小吋内的新鲜野蔷薇叶榨汁, 并将榨汁得到的汁液在零下 45°C 冻干, 制成野蔷薇冻干粉备用; [0087] S10, picking and extracting fresh wild rose leaf juice in 12 small pots, and lyophilizing the juice obtained by juicing at minus 45 ° C to prepare a wild rose lyophilized powder for use;
[0088] S20、 将从药店购买到的干燥的杠板归全草蒸煮, 将蒸煮过滤后获得的滤液在 3[0088] S20, the dried bar plate purchased from the pharmacy is returned to the whole grass for cooking, and the filtrate obtained after cooking and filtering is 3
5°C条件下进行风干, 制得杠板归风干粉; Air drying at 5 ° C, to obtain a bar-dried air-dried powder;
[0089] S30、 取野蔷薇冻干粉 750g和所述杠板归风干粉 250g混合得到中药组合物, 将 该中药组合物按常规方法制成冲剂包装备用。 [0089] S30, taking 750g of wild rose lyophilized powder and 250g of the dried bark powder to obtain a traditional Chinese medicine composition, and preparing the traditional Chinese medicine composition into a granule package according to a conventional method.
[0090] [0090]
[0091] 实施例 5为一种治疗肺病的中药组合物, 由以下组分组成: 野蔷薇冻干粉 700g 和杠板归风干粉 300g, 其制备过程如下: [0091] Example 5 is a traditional Chinese medicine composition for treating lung diseases, which is composed of the following components: wild rose lyophilized powder 700 g and slab-dried air-dried powder 300 g, and the preparation process is as follows:
[0092] S10、 取采摘 12小吋内的新鲜野蔷薇榨汁, 并将榨汁得到的汁液在零下 40°C冻 干, 制成野蔷薇冻干粉备用; [0092] S10, picking and extracting fresh wild rose juice in 12 small pots, and lyophilizing the juice obtained by juicing at minus 40 ° C to prepare a wild rose lyophilized powder for use;
[0093] S20、 将杠板归蒸煮, 将蒸煮过滤后获得的滤液在 35°C条件下进行风干, 制得 杠板归风干粉; [0093] S20, the bar plate is steamed, and the filtrate obtained by the retort filtration is air-dried at 35 ° C to obtain a bar-dried air-dried powder;
[0094] S30、 取野蔷薇冻干粉 600g和所述杠板归风干粉 400g混合得到中药组合物, 将 该中药组合物按常规方法进行制粒, 制成冲剂包装备用。 [0094] S30, taking wild rose lyophilized powder 600g and the bar plate dry air powder 400g to obtain a traditional Chinese medicine composition, and the traditional Chinese medicine composition is granulated according to a conventional method, and is prepared into a granule package for use.
[0095] [0095]
[0096] 实施例 6: 取纯野蔷薇冻干粉 1000g制成冲剂。 Example 6: 1000 g of pure wild rose lyophilized powder was taken as a granule.
[0097]
[0098] 实施例 7: 取 35°C风干制得纯杠板归风干粉 lOOOg制成冲剂。 [0097] [0098] Example 7: taking 35 ° C air-dried to obtain a pure bar plate air-dried powder 100 g of powder into a powder.
[0099] [0099]
[0100] 实施例 8: 取野蔷薇冻干粉 300g和 35°C风干制得杠板归风干粉 700g混合制成冲 剂作。 Example 8: Take the wild lyophilized powder 300g and air-dried at 35 ° C to prepare a slab-dried air-dried powder of 700 g to prepare a granule.
[0101] 包装及服用方法: 实施例 1~5及对照实验 1~3的产品吋, 均制成含 20g/剂中药组 合物的包装, 患者早中晚各服用一剂。 治疗原理过程如图 2所示。 [0101] Packing and taking method: The products of Examples 1 to 5 and the control experiments 1 to 3 were all packaged in a composition containing 20 g/dose of the traditional Chinese medicine composition, and the patients were given one dose each morning and evening. The treatment principle process is shown in Figure 2.
[0102] [0102]
[0103] 案例一: 徐某, 男, 85岁, 宁化县曹坊乡竹根村人, 医院诊断肺癌。 症状: 肺 积液剧痛, 12天无大便, 医院治疗 12月, 医院放弃治疗。 服用本发明实施例一 产品, 72小吋剧痛消失, 肺积液导流吋无积液流出, 用药 10天检査, 积液消失 [0103] Case 1: Xu, male, 85 years old, from Zhugen Village, Caofang Township, Ninghua County, hospital diagnosed lung cancer. Symptoms: Pulmonary effusion pain, 12 days without stool, hospital treatment December, the hospital gave up treatment. Taking the product of the first embodiment of the present invention, the pain of the 72 small sputum disappeared, the drainage of the pulmonary effusion was not discharged, and the drug was removed for 10 days, and the effusion disappeared.
[0104] 案例二: 俞某, 男, 85岁, 上海医院诊断肺结核。 症状: 肺积液导致呼吸困难 , 腿部水肿, 服用本发明实施例 6产品, 10天后检査肺积液剩余 60%, 30天后积 液还剩余 10%。 [0104] Case 2: Yu Mou, male, 85 years old, Shanghai Hospital diagnosed tuberculosis. Symptoms: Pulmonary effusion causes difficulty in breathing, edema of the legs, taking the product of Example 6 of the present invention, and after 60 days, the remaining 60% of the pulmonary effusion is examined, and after 30 days, 10% remains of the effusion.
[0105] 案例三: 蒋某, 男, 83岁, 福建龙岩人。 医院诊断肺癌。 症状: 肺积液剧痛, 服用本发明实施例 7产品, 10天后检査肺积液剩余 70%, 30天后积液还剩余 40% [0105] Case 3: Jiang, male, 83 years old, Longyan, Fujian. The hospital diagnosed lung cancer. Symptoms: Pulmonary effusion is very painful. After taking the product of Example 7 of the present invention, the remaining 70% of the lung effusion is checked after 10 days, and 40% of the effusion remains after 30 days.
[0106] 案例四: 周某, 男, 80岁, 福建泉州人。 医院诊断肺气肿。 症状: 肺积液导致 胸痛, 服用本发明实施例 8产品, 10天后检査肺积液剩余 50%, 30天后积液还剩 余 5%。 [0106] Case 4: Zhou, male, 80 years old, from Quanzhou, Fujian. The hospital diagnosed emphysema. Symptoms: Pulmonary effusion causes chest pain. After taking the product of Example 8 of the present invention, the remaining 50% of the pulmonary effusion is examined 10 days later, and 5% of the effusion remains after 30 days.
[0107] 案例五: 曾某, 女, 76岁, 福建三明市人, 肺结核、 肺积液, 病危通知书。 症 状: 肺积液导致胸痛严重, 服用实施例 1产品, 8天后检査积液消失, 10天后肺 结核症状得到明显缓解。 [0107] Case 5: Zeng, female, 76 years old, from Sanming City, Fujian Province, tuberculosis, pulmonary effusion, critical illness notice. Symptoms: Pulmonary effusion caused severe chest pain. After taking the product of Example 1, the effusion disappeared after 8 days, and the symptoms of pulmonary tuberculosis were significantly relieved 10 days later.
[0108] 案例六: 黄某, 男, 92岁, 浙江温州人, 肺结核、 肺积液, 病危通知书, 症状Case 6: Huang, male, 92 years old, Wenzhou, Zhejiang, tuberculosis, pulmonary effusion, critical illness notice, symptoms
: 肺积液导致胸痛严重, 服用实施例 2产品, 15天检査积液消失, 肺活动恢复 80: Pulmonary effusion causes severe chest pain, taking the product of Example 2, checking the disappearance of effusion in 15 days, recovery of lung activity 80
% , 肺结核症状明显改善。 %, tuberculosis symptoms improved significantly.
[0109] 案例七: 胡某, 女, 38岁, 福建三明尤溪县人, 癌症肿瘤已转移头部, 服用实 施例 3产品, 15天检査积液消失, 肿瘤细胞扩散面积小; 30天后检査肿瘤细胞基
本无扩散。 Case 7: Hu, female, 38 years old, from Youxi County, Sanming, Fujian Province, cancer tumor has metastasized to the head, taking the product of Example 3, 15 days to check the disappearance of effusion, the tumor cell diffusion area is small; 30 days later Check tumor cell base There is no proliferation.
[0110] 案例八: 赖某, 上海, 女, 45岁, 肺癌晚期, 肺部积液严重导致胸痛, 服用实 施例 5产品, 12天检査积液消失, 肺癌细胞扩散面积小; 40天后检査肺癌细胞基 本无扩散。 [0110] Case 8: Lai, Shanghai, female, 45 years old, advanced lung cancer, severe pulmonary effusion leading to chest pain, taking the product of Example 5, 12 days to check the effusion disappeared, lung cancer cell diffusion area is small; 40 days later The lung cancer cells were found to be substantially non-proliferative.
[0111] 案例九: 刘某, 福建三明人, 男 75岁, 肺气肿, 服用实施例 1产品, 24小吋见 效, 15天检査明显好转, 30天治愈。 [0111] Case 9: Liu, Fujian Sanming, male 75 years old, emphysema, taking the example 1 product, 24 hours of effective, 15 days of examination improved significantly, 30 days of cure.
[0112] 案例十: 张某, 上海人, 男 85岁, 肺钙化, 肺功能仅 30重量份, 经服用实施例[0112] Case 10: Zhang, Shanghai native, male 85 years old, pulmonary calcification, lung function only 30 parts by weight, after taking the example
4产品, 7天后可行走一公里不休息, 原 50m需休息一次。 4 products, can walk for one kilometer after 7 days without rest, the original 50m need to take a break.
[0113] 案例十一: 李某, 上海人, 男, 25岁, 肺钙化, 肺功能仅 40重量份, 经服用实 施例 1产品, 5天可行走一公里不休息, 原 50m需休息一次。 [0113] Case 11: Li, Shanghai, male, 25 years old, lung calcification, lung function is only 40 parts by weight, after taking the product of Example 1, 5 days can walk for one kilometer without rest, the original 50m need to take a break.
[0114] [0114]
[0115] 综上所述, 本发明提供的一种治疗肺病的中药组合物、 制备工艺及用途具有有 效控制积液的产生、 治疗肺病效果显著的优点。 该中药组合物具有: 1) 配方科 学合理, 疗效显著。 针对肺积液的产生的根本原因为病毒侵蚀或绿脓杆菌, 本 发明在充分利用中药组分自身功效的同吋合理设计各组分的重量份, 使得中药 组合物能够最大程度地与病毒及抗绿农杆菌进行对抗治疗, 达到消灭病毒及绿 农杆菌, 进而控制积液的产生。 2) 治愈吋间短, 肺活力恢复好。 采用本发明方 案可在 3-7天内实现肺积液明显减少, 可在 8天内全部消失, 且通过本发明配方的 中药组合物药疗后的肺活力恢复好。 3) 治疗兼修复, 治疗更彻底。 本发明利用 野蔷薇兼具有增强免疫力、 细胞修复的功效, 可以在治疗的同吋对因疾病引起 的坏死细胞进行修复, 使得治疗效果更彻底, 降低再复发的风险。 4) 毒副作用 小, 适用范围广。 所有组分均为天然药物, 对人体毒副作用小; 本发明方案对 各种因素引起的肺积液都具有明显的效果, 且能广泛用于其他肺气肿、 肺钙化 、 肺纤维化、 肺癌药物的辅助治疗成分, 且能用于各种肺病治疗药物治疗过程 中的修复药物, 毒副作用小, 对其他药物成分的药效无副作用。
In summary, the present invention provides a traditional Chinese medicine composition for treating lung diseases, a preparation process and a use thereof, which have the advantages of effectively controlling the production of effusion and treating lung diseases significantly. The traditional Chinese medicine composition has: 1) The formula science is reasonable and the curative effect is remarkable. The root cause of the production of pulmonary effusion is virus erosion or Pseudomonas aeruginosa. The present invention makes full use of the self-efficiency of the traditional Chinese medicine component to rationally design the weight parts of each component, so that the traditional Chinese medicine composition can maximize the virus and Anti-Green Agrobacterium is used for anti-treatment, to eliminate viruses and Agrobacterium tumefaciens, and to control the production of effusion. 2) The cure is short, and the lung vitality is restored. With the method of the present invention, the pulmonary effusion can be significantly reduced within 3-7 days, and can be completely disappeared within 8 days, and the lung vitality after the treatment by the traditional Chinese medicine composition of the present invention is recovered. 3) Treatment and repair, treatment is more thorough. The invention utilizes the wild rose and has the effects of enhancing immunity and cell repair, and can repair the necrotic cells caused by the disease in the treatment of the same sputum, so that the treatment effect is more thorough and the risk of recurrence is reduced. 4) The toxic and side effects are small and the scope of application is wide. All components are natural drugs, and have little toxic side effects to human body; the present invention has obvious effects on pulmonary effusion caused by various factors, and can be widely used for other emphysema, pulmonary calcification, pulmonary fibrosis, lung cancer. The auxiliary therapeutic component of the medicine, and can be used for repairing drugs in the treatment of various lung diseases, has little toxic and side effects, and has no side effects on the efficacy of other pharmaceutical ingredients.
Claims
[权利要求 1] 一种治疗肺病的中药组合物, 其特征在于: 包括野蔷薇。 [Claim 1] A traditional Chinese medicine composition for treating lung diseases, which comprises: wild rose.
[权利要求 2] 根据权利要求 1所述的治疗肺病的中药组合物, 其特征在于: 还包括 杠板归。 [Claim 2] The traditional Chinese medicine composition for treating lung diseases according to claim 1, further comprising: a slab return.
[权利要求 3] 根据权利要求 1所述的治疗肺病的中药组合物, 其特征在于: 所述野 蔷薇的重量百分数至少为 30%。 [Claim 3] The traditional Chinese medicine composition for treating lung diseases according to claim 1, wherein the wild rose has a weight percentage of at least 30%.
[权利要求 4] 根据权利要求 2所述的治疗肺病的中药组合物, 其特征在于: 所述野 蔷薇为 60~85重量份, 所述杠板归为 15~40重量份。 [Claim 4] The traditional Chinese medicine composition for treating lung diseases according to claim 2, wherein the wild rose is 60 to 85 parts by weight, and the bar is classified into 15 to 40 parts by weight.
[权利要求 5] 根据权利要求 2所述的治疗肺病的中药组合物, 其特征在于: 所述野 蔷薇为将野蔷薇榨汁后的汁液进行冻干而获得的冻干粉, 所述杠板归 是将杠板归全草经蒸煮过滤后的滤液在 50°C及以下条件下进行风干后 制得的风干粉。 [Claim 5] The traditional Chinese medicine composition for treating lung diseases according to claim 2, wherein the wild rose is a lyophilized powder obtained by lyophilizing juice obtained by extracting wild rose, the slab It is an air-dried powder obtained by air-drying the filtrate after the filter is filtered and dried at 50 ° C and below.
[权利要求 6] 根据权利要求 5所述冶疗肺病的中药组合物, 其特征在于: 所述杠板 归的风干粉的制备方法为: 将杠板归全草先在 95~100°C的水中浸泡 6~ 8小吋, 然后将浸泡后的水与杠板归全草一同在 85~95°C下蒸煮 l~1.5h 后过滤, 将得到的滤液在 45~50°C下进行蒸发直至含水率低于 5%, 获 得糊状物, 再将得到的糊状物于 50°C及以下的条件下进行风干。 [Claim 6] The traditional Chinese medicine composition for treating lung diseases according to claim 5, wherein: the method for preparing the air-dried powder of the slab is: the slab is returned to the whole grass at 95~100 °C Soak in water for 6~ 8 hours, then dilute the water and the plate to the whole grass and cook at 85~95 °C for 1~1.5h, then filter, and evaporate the filtrate at 45~50 °C until it is evaporated. The water content was less than 5%, a paste was obtained, and the obtained paste was air-dried at 50 ° C or lower.
[权利要求 7] —种制备治疗肺病的中药组合物的制备工艺, 其特征在于: 包括以下 步骤: [Claim 7] A process for preparing a traditional Chinese medicine composition for treating lung diseases, comprising: the following steps:
S10、 取采摘 12小吋内的野蔷薇叶进行榨汁, 并将榨汁后获得的汁液 在零下 45°C~零下 25°C下进行冻干, 制成野蔷薇冻干粉。 S10. Picking and extracting the wild rose leaves in 12 small pots for juice extraction, and lyophilizing the juice obtained after juicing is lyophilized at minus 45 ° C to minus 25 ° C to prepare wild rose lyophilized powder.
[权利要求 8] 根据权利要求 7所述的一种制备治疗肺病的中药组合物的制备工艺, 其特征在于: 还包括以下步骤: [Claim 8] The preparation process of a traditional Chinese medicine composition for treating lung diseases according to claim 7, further comprising the following steps:
S20、 将杠板归进行蒸煮, 将蒸煮过滤后获得的滤液在 50°C以下条件 下进行风干, 制得杠板归风干粉。 S20, the bar plate is subjected to cooking, and the filtrate obtained by the retort filtration is air-dried under the condition of 50 ° C or lower to obtain a bar-dried air-dried powder.
[权利要求 9] 根据权利要求 8所述的一种制备治疗肺病的中药组合物的制备工艺, 其特征在于: 还包括以下步骤: [Claim 9] The preparation process of a traditional Chinese medicine composition for treating lung diseases according to claim 8, further comprising the following steps:
S30、 将所述野蔷薇冻干粉和所述杠板归风干粉按 60~85: 15~40的重
量比进行混合, 得到所述中药组合物。 S30, the wild rose lyophilized powder and the bar plate are dried to a dry weight of 60 to 85: 15 to 40 The amount ratio is mixed to obtain the traditional Chinese medicine composition.
[权利要求 10] —种将如权利要求 1~6任一项所述的治疗肺病的中药组合物在制备用 于治疗肺积液、 肺气肿、 肺钙化、 肺纤维化、 肺癌或肺修复的药物中 的应用。
[Claim 10] The traditional Chinese medicine composition for treating lung diseases according to any one of claims 1 to 6 for preparation for treating pulmonary effusion, emphysema, pulmonary calcification, pulmonary fibrosis, lung cancer or lung repair The application of the drug.
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