CN109464534A - The composition and preparation method thereof for preventing and treating burn and scald - Google Patents
The composition and preparation method thereof for preventing and treating burn and scald Download PDFInfo
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- CN109464534A CN109464534A CN201910031851.5A CN201910031851A CN109464534A CN 109464534 A CN109464534 A CN 109464534A CN 201910031851 A CN201910031851 A CN 201910031851A CN 109464534 A CN109464534 A CN 109464534A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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Abstract
The invention discloses a kind of composition for preventing and treating burn and scald, including adhesive rehmannia leaf and tung oil, the mass ratio of adhesive rehmannia leaf and tung oil is 50~150: 75~225.The invention also discloses a kind of preparation methods of composition for preventing and treating burn and scald, include the following steps: S1, adhesive rehmannia leaf is carried out heating baking, be then crushed to powdered；S2, the adhesive rehmannia leaf handled through step S1 is uniformly mixed with tung oil to get final product composition.The composition of prevention and treatment burn and scald of the invention is rapid-action, ingredient is simple, can anti-inflammatory analgesic, remove necrosis and promote granulation, II degree and it is following more after do not stay scar, scald for II degree and below and have better effect.It is preparation method simple process of the invention, at low cost, and can prepare it is rapid-action, more after do not stay scar, ingredient it is simple, can anti-inflammatory analgesic and the prevention and treatment burn and scald removed necrosis and promoted granulation composition.
Description
Technical field
The present invention relates to burn and scald fields, especially prevent and treat the composition and preparation method thereof of burn and scald.
Background technique
Burn is a kind of common wound, is one of the important wound for threatening human health.Chinese medicine thinks the cause of disease of burn
It is fire toxin or heat toxin, belongs to " non-endo-non-exogenous cause ".Burn is divided into III degree, II degree and accounts for the most of of burn crowd below, if in hospital
Treatment is often used antibiotic, dressing, or even needs to make skin graft, and improves medical treatment cost, wastes medical resource, and antibiosis is known as pair
Effect.Traditional Chinese medicine for outer use is important one of the remedy measures of middle and small area burn wound, but Chinese materia medica preparation exists comprising complex in composition,
Generally between 5~30 kinds, and the methods of infusion process is needed come the effective elements of the medicine in extracting more, cause manufacture craft cumbersome, when
Between, human cost it is high, expense is also high.
Summary of the invention
The technical problem to be solved by the present invention is to overcome the deficiencies in the prior art, provide it is a kind of it is rapid-action, ingredient is simple, energy
Anti-inflammatory analgesic, remove necrosis and promote granulation, II degree and it is following more after do not stay scar prevention and treatment burn and scald composition, scald for II degree and below
It has better effect.The present invention also provides a kind of simple process, it is at low cost can prepare it is rapid-action, more after do not stay that scar, ingredient be simple, energy
The preparation method of the composition of anti-inflammatory analgesic and the prevention and treatment burn and scald removed necrosis and promoted granulation.
In order to solve the above technical problems, the technical scheme adopted by the invention is that:
The composition of burn and scald is prevented and treated, effective component includes adhesive rehmannia leaf and tung oil, and the mass ratio of the adhesive rehmannia leaf and tung oil is 50
~150: 75~225.
The composition of above-mentioned prevention and treatment burn and scald, it is preferable that the mass ratio of the adhesive rehmannia leaf and tung oil is 50~100: 65
~120.
The composition of above-mentioned prevention and treatment burn and scald, it is preferable that the mass ratio of the adhesive rehmannia leaf and tung oil is 50: 52.5.
The composition of above-mentioned prevention and treatment burn and scald, it is preferable that the composition is outer painting smearing.
The composition of above-mentioned prevention and treatment burn and scald, it is preferable that the adhesive rehmannia leaf is wild adhesive rehmannia leaf.
The inventive concept total as one, the present invention also provides a kind of preparation method of composition for preventing and treating burn and scald, packets
Include following steps:
S1, adhesive rehmannia leaf is subjected to heating baking, is then crushed to powdered, placement cooling；
S2, it will be uniformly mixed through the resulting adhesive rehmannia leaf of step S1 processing with tung oil to get final product composition.
The preparation method of the composition of above-mentioned prevention and treatment burn and scald, it is preferable that in the step S2, the adhesive rehmannia leaf and paulownia
The mass ratio of oil is 50~150: 75~225.
The preparation method of the composition of above-mentioned prevention and treatment burn and scald, it is preferable that in the step S1, what the heating baked
Temperature is to heat 2~3 minutes prior to 60~80 DEG C, then at 20~30 DEG C of 2~4min of heating.
The preparation method of the composition of above-mentioned prevention and treatment burn and scald, it is preferable that further include by adhesive rehmannia leaf before the step S1
The step of being dried；The drying is to dry or dry.
The preparation method of the composition of above-mentioned prevention and treatment burn and scald, it is preferable that described to be broken for twisting into pieces in the step S1
Or it crushes.
The preparation method of the composition of above-mentioned prevention and treatment burn and scald, it is preferable that the final product composition is placed in closed container
Middle preservation or ready-to-use.
The present invention provides a kind of Chinese materia medica preparation for treating burn and scald, and active material is adhesive rehmannia leaf and tung oil, boiling hot for burning
Local pyrexia, redness, bubble, decortication caused by hurting.This preparation has clearing heat and detoxicating, anti-inflammatory analgesic, the effect of removing necrosis and promoting granulation, and works
Fastly, more after do not stay scar, for II degree and following scald has better effect.
Compared with the prior art, the advantages of the present invention are as follows:
1, the composition of prevention and treatment burn and scald of the invention is rapid-action, analgesic is fast, be not easy to stay more afterwards scar, ingredient it is simple, can anti-inflammatory town
It pain and removes necrosis and promote granulation and at low cost, scalds mainly for II degree and below.Treatment can carry out at home, not need gnotobasis,
It does not need physiological saline etc. to irrigate, directly smear, rapid-onset does not delay treatment time, and patient restores fast, without bad anti-
It answers.
2, the composition of prevention and treatment burn and scald of the invention is by the proportion of control adhesive rehmannia leaf and tung oil, can preferably with the surface of a wound
It is close to, the preferably affine surface of a wound, reduces wound fluid, so that the surface of a wound is formed medicine scab barrier, prevent from infecting under scab, protective epithelium is raw
Long effect.
3, the composition of prevention and treatment burn and scald of the invention is for II degree and following scald is not necessarily to while taking antibiotic, analgesic
The other drugs such as medicine avoid drug-induced bad hair and answer, save money.
4, the preparation method simple process of the composition of prevention and treatment burn and scald of the invention, easy to accomplish, manufacturing cost is low, gram
The shortcomings that having taken existing infusion process time-consuming consumption cost.
5, it after the composition use of prevention and treatment burn and scald of the invention, does not need to bind up a wound, directly exposure, time saving province
Power saves expense.
Specific embodiment
The present invention is described in further details below with reference to specific embodiment.Material employed in following embodiment
It is commercially available with instrument.
A kind of composition of prevention and treatment burn and scald of the invention, active material are made of adhesive rehmannia leaf and tung oil.
The mass ratio of the adhesive rehmannia leaf and tung oil is 50~150: 75~225.If adhesive rehmannia leaf is more, tung oil is few, can not create
Face is uniformly smeared, and wound healing is influenced；If adhesive rehmannia leaf is few, tung oil is more, and medical fluid is too dilute, medicine when it is few to will lead to dosage, and smearing
Liquid can flow away from the surface of a wound, can not be bonded with the surface of a wound, therapeutic effect is not achieved, and if adhesive rehmannia leaf it is very few, the drug effect being not achieved.
In composition, the mass ratio of the adhesive rehmannia leaf and tung oil is preferably 50~100: 65~120, and further preferably 50: 52.5.
In the drug composition that the present invention is included, glutinous rehmannia leaf system scrophulariaceae has the effect of detoxification sore treatment, is usually used in
It dislikes, tinea of feet and hands, but so far not directly using the research of adhesive rehmannia leaf treatment burn and scald；Tung oil can control scabies, ulcer on the shank, scald fire
Wound, pernio chap, purulent inflammation, ecphyaditis, gallbladder pancreatitis, tonsillitis, and the effect for the treatment of burn and scald is used alone in tung oil
It is bad.
After adhesive rehmannia leaf, tung oil mixing interaction in composition of the invention, drug component mutual cooperation effect can be sent out
The effect of waving multi-efficiency, promoting the clearing heat and detoxicating of drug entirety, anti-inflammatory analgesic and remove necrosis and promote granulation, can accelerate wound healing, have
Effect treatment burn and scald, has no adverse reaction, and be not easy to stay scar, and particularly with II degree and following scald has better effect.
The composition is prevention and treatment burn and scald treating oil, is smeared using outer painting.
The adhesive rehmannia leaf is preferably wild adhesive rehmannia leaf.
A kind of preparation method of the composition of prevention and treatment burn and scald of the invention, includes the following steps:
S1, adhesive rehmannia leaf is subjected to heating baking, is then crushed to powdered, placement cooling；
S2, it will be uniformly mixed through the resulting adhesive rehmannia leaf of step S1 processing with tung oil to get final product composition.
Unique pharmaceutical procedures that medicine for external application of the invention uses can make two drugs keep best available ingredient, and component
Effect is played to the full extent, is mutually cooperateed with.
Compared with the traditional Chinese medicine for outer use of other treatment burn and scald, this composition components is simple, and drug cost is also relatively
It is low, it can be patient's Economy type medicine expense, and manufacture craft is simple, it is time saving and energy saving but curative for effect.In addition, patient does not spend doctor
Institute can treat at home, not only facilitate patient, but also reduce the waste of medical resource, for national Economy type medicine cost.
In the step S2, the mass ratio of the adhesive rehmannia leaf and tung oil is 50~150: 75~225.
In the step S1, the purpose that the heating bakes be in order to remove moisture, the heating bake be preferably prior to
60~80 DEG C are heated 2~3 minutes, and then at 20~30 DEG C of 2~4min of heating, adhesive rehmannia leaf is drier, needs the time shorter.The present invention
In, heating bakes and is not limited to the heating mechanism, help to obtain good drying effect using the heating mechanism.
Before the step S1, it is also preferable to include adhesive rehmannia leaf is dried；The drying is to dry or dry.Through
Be conducive to improve the holding time of adhesive rehmannia leaf after drying, and can be shortened baking time, grasps and bake the duration and degree of heating.
In the step S1, described be crushed preferably is twisted into pieces or is crushed.
The final product composition is placed in closed container such as glass container, plastic containers, can extend retention time, suffers from
Person can directly use when burning, and can win treatment time.If composition is ready-to-use, oil-proof any container.
The composition of prevention and treatment burn and scald of the invention can be used to prevent and treat burn or scald.Application method is that medicine is applied to burning to scald
Hurt at the surface of a wound, daily 3~4 times.Coating protects moisture state with part, and stream is not advisable, the exposure surface of a wound.
Embodiment 1
A kind of composition of prevention and treatment burn and scald of the invention, including adhesive rehmannia leaf and tung oil, specifically use adhesive rehmannia leaf 50g, tung oil
52.5g is made.
A kind of preparation method of the composition of the prevention and treatment burn and scald of the present embodiment, includes the following steps:
S1, it shines Chinese medicine: being dried after adhesive rehmannia leaf is cleaned；
S2, it bakes Chinese medicine: dry 50g adhesive rehmannia leaf being put into pot and is heated, first 60~80 DEG C 2~3 minutes, then at 20~30 DEG C
2~4min takes out, and twists into pieces, places cooling.Adhesive rehmannia leaf is drier, needs the time shorter；
S3, spice mixing: the 50g adhesive rehmannia leaf baked is mixed with 52.5g tung oil according to the ratio, is directly applied on the surface of a wound.If
When area is larger, the composition of more prevention and treatment burn and scalds is configured further according to mass ratio.
Application method: medicine is applied at empyrosis wound surface, and daily 3~4 times.Coating protects moisture state with part, does not flow and is
Preferably, the exposure surface of a wound.
Embodiment 2
The composition treatment burn and scald clinical case of the resulting prevention and treatment burn and scald of the embodiment of the present invention 1 has reached for many years, all cures,
There is good therapeutic effect for II degree and following burn and scald.It is below only partial clinical case, specific dosage are as follows: will match
The medical fluid set applies 3~4 times daily.
1, Wu so-and-so, female, 2 years old.Zhangjiajie of Hunan Province city, sand wooden bridge town, the Cili County village Zhao Jiapu.Boiled water scald, right thigh
Inside.Ineffective after fire brigade, county was with medicinal ointment therapy three days to come to treat, entire wound is red and swollen at this time, multiple size water
Bubble, there is decortication, and edge is white, uses medical fluid dressing of the present invention instead, heals after a week, no scar.
2, Wu so-and-so, male, 5 years old.Zhangjiajie of Hunan Province city, sand wooden bridge town, Cili County people from the village Zhao Jiapu.It is fallen down when warming oneself by a fire to fire
In a heatable brick bed, right hand burn, multiple big vesicles, gnawing pains take no rest, screams.It is painted with pain relief after medicine, is fully recovered after ten days, no scar.
3, it is tall and erect so-and-so, male, 42 years old.Zhangjiajie of Hunan Province city, sand wooden bridge town, Cili County people from the village Zhao Jiapu.Motorcycle exhaust pipe
Scald, left leg inside, medication are healed after four days, no scar.
4, bandit so-and-so, male, 45 years old.Zhangjiajie of Hunan Province city, sand wooden bridge town, Cili County people from the village Yang Jiata.Motorcycle exhaust pipe
Scald, left leg, in commune hospital, after one week treatment comes to treat upon somebody's introduction without marked improvement.Mud is rotten at the entire injury of patient
Shape is red and swollen.After smearing this medicine, wound improves after five days, fully recovers after continuing medication ten days.Non- scar, skin are complete.
5, Mr. Li, male, 25 years old.Zhangjiajie of Hunan Province city Cili County people from the village Tong Jinpu.Right thigh upper inner, scald
Latter week treatment.Affected part is red and swollen, and in the shape that festers, right leg cannot stand and normally walk wound.After this medicine eight days, patient can stand
It is vertical to carry water, it heals without scar.
6, Mr. Li, female, 65 years old, both hands burn.Mosquito is burnt in mosquito net with kerosene lamp, causes mosquito net on fire.Multiple water
Bubble, broken skin, use no scar that after this medicine, heals after half a month.
7, it is tall and erect so-and-so, male, 7 years old.Zhangjiajie of Hunan Province city, sand wooden bridge town, Cili County cucurbit people from village.Fiery heap of stepping on when object for appreciation is made
It scalds at right instep and toes front half-end, heals within six days after smearing this medicine, no scar.
8, bavin so-and-so, female.Zhangjiajie of Hunan Province city Cili County people from the village Yuan Ping.Heavier trunk scald, area are larger.It is said that
It treats and does not improve yet after half a month elsewhere about, treat upon somebody's introduction.It was improved with 20 days after this medicine, the small portion in affected part when healing
Point pigmentation, skin color with it is normally variant, it is subsequent not observe again.
9, Deng, female, 10 years old, people from Changsha.Right crus of diaphragm rear heel scald.It is invalid after cubic metre of earth treatment, it is big vesicle, red
It is swollen, it is healed with this medicine latter week, no scar.
10, it is tall and erect so-and-so, male, 13 years old, Zhangjiajie of Hunan Province city Cili County people from the village Zhao Jiapu.Overhead scald, decortication play water
Bubble.(specifically unknown) is ineffective after other methods are treated comes to treat, and is fully recovered with after this medicine six days.
11, it is tall and erect so-and-so, male, 62 years old.The Zhangjiajie of Hunan Province city Cili County village Zhao Jiapu Chen Zi bridge group.It warms oneself by a fire scald.Red and swollen,
Bubble, decortication were healed with 16 days after this medicine, do not stay scar.
12, Wu so-and-so, female, 11 years old.Zhangjiajie of Hunan Province city, the village Zhao Jiapu, Cili County is rich to be combined people.Neck boiled water scald.
Redness, big vesicle.It heals within 15 days after applying this medicine, without obvious scar, the place of only about 1cm or so feels that the colour of skin is newer.
13, Wu so-and-so, female, 19 years old.People from Changsha, Hunan.Oil splashes scald when cooking.It gets blister, peel.Use nanometer
Silver is ineffective after smearing four days, reuses rehabilitation after five days after this medicine, non-scar, the only sense of place of 0.5cm or so
Feel that the colour of skin is newer.
14, bavin so-and-so, female, 68 years old.Zhangjiajie of Hunan Province city, sand wooden bridge town, Cili County is rich to be combined people.Breast boiled water scald.
Erythrosis is got blister, pain, untreated at that time.Exacerbation of symptoms two days later is given chelated iodine and is smeared three days, and appearance is without obvious
Change, heals within four days after using this medicine instead, do not stay scar.
15, Wu so-and-so, male, 14 years old.Zhangjiajie of Hunan Province city, sand wooden bridge town, the Cili County village Zhao Jiapu Green Dragon gulf group people.The right hand
Firecrackers be wound, and bubble is red and swollen, be restored within seven days after medication, no scar.
Although the present invention is disclosed as above with preferred embodiment, however, it is not intended to limit the invention.It is any to be familiar with ability
The technical staff in domain, without deviating from the scope of the technical scheme of the present invention, all using the technology contents pair of the disclosure above
Technical solution of the present invention makes many possible changes and modifications or equivalent example modified to equivalent change.Therefore, all
Without departing from the content of technical solution of the present invention, according to the present invention technical spirit any simple modification made to the above embodiment,
Equivalent variations and modification, all shall fall within the protection scope of the technical scheme of the invention.
Claims (10)
1. the composition for preventing and treating burn and scald, which is characterized in that effective component includes adhesive rehmannia leaf and tung oil, the adhesive rehmannia leaf and tung oil
Mass ratio be 50~150: 75~225.
2. the composition of prevention and treatment burn and scald as described in claim 1, which is characterized in that the mass ratio of the adhesive rehmannia leaf and tung oil
It is 50~100: 65~120.
3. the composition of prevention and treatment burn and scald as described in claim 1, which is characterized in that the mass ratio of the adhesive rehmannia leaf and tung oil
It is 50: 52.5.
4. the composition of the prevention and treatment burn and scald as described in claims 1 to 3 any one, which is characterized in that the composition is
Outer painting is smeared.
5. the composition of the prevention and treatment burn and scald as described in claims 1 to 3 any one, which is characterized in that the adhesive rehmannia leaf is
Wild adhesive rehmannia leaf.
6. the preparation method for preventing and treating the composition of burn and scald, which comprises the steps of:
S1, adhesive rehmannia leaf is subjected to heating baking, be then crushed to powdered；
S2, the adhesive rehmannia leaf handled through step S1 is uniformly mixed with tung oil to get final product composition.
7. the preparation method of the composition of prevention and treatment burn and scald as claimed in claim 6, which is characterized in that in the step S2,
The mass ratio of the adhesive rehmannia leaf and tung oil is 50~150: 75~225.
8. the preparation method of the composition of prevention and treatment burn and scald as claimed in claims 6 or 7, which is characterized in that the step S1
In, the temperature that the heating bakes is to heat 2~3 minutes prior to 60~80 DEG C, then at 20~30 DEG C of 2~4min of heating；
It is described to be broken for twisting into pieces or crush in the step S1.
9. the preparation method of the composition of prevention and treatment burn and scald as claimed in claims 6 or 7, which is characterized in that the step S1
Before, further include the steps that for adhesive rehmannia leaf being dried；The drying is to dry or dry.
10. the preparation method of the composition of prevention and treatment burn and scald as claimed in claims 6 or 7, which is characterized in that the finished product group
It closes object and is placed in preservation or ready-to-use in closed container.
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Non-Patent Citations (3)
| Title |
|---|
| 仲素霞: "高效液相色谱法测定复方地黄软膏中盐酸小檗碱含量", 《中国现代药物应用》 * |
| 李卫红，李平: "自制地榆炭散为主治疗烧伤105例", 《中国中西医结合杂志》 * |
| 邓理有: "清热燥湿话黄柏", 《家庭中医药》 * |
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