CN113694107A

CN113694107A - Composition for treating burns and scalds and preparation method thereof

Info

Publication number: CN113694107A
Application number: CN202111040250.4A
Authority: CN
Inventors: 李军; 席世扬; 晏国武
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-09-06
Filing date: 2021-09-06
Publication date: 2021-11-26

Abstract

The invention belongs to the technical field of Chinese herbal medicines, and discloses a composition for treating burns and scalds and a preparation method thereof. The composition takes garden burnet and rhizoma atractylodis as natural plant raw materials, borneol is matched with the garden burnet and the rhizoma atractylodis, and all the components are matched with each other, so that the aim of comprehensively treating burns and scalds is fulfilled. The composition has effects of clearing heat and detoxicating, cooling blood and hemostasis, detoxicating and healing sore, resisting bacteria and diminishing inflammation, has effects of promoting wound healing for burn and scald, rapidly relieving swelling and pain, has no addition of any chemical reagent, has no toxic and side effects, and has extremely high cure rate and safety. The preparation method adopts purification and drying modes to obtain the powdery external preparation, the mode can furthest obtain the effective components in the raw materials, and the particle size of the powder obtained by the mechanical drying mode is smaller, so that the contact surface between the raw materials and the wound is improved, the treatment efficiency is further improved, and the aim of quickly curing the wound is fulfilled.

Description

Composition for treating burns and scalds and preparation method thereof

Technical Field

The invention belongs to the technical field of Chinese herbal medicines, and particularly relates to a composition for treating burns and scalds and a preparation method thereof.

Background

Burn and scald are common accidental wounds which seriously harm the health of people, and the skin injury problem caused by high temperature exists everywhere in daily life of people at present. The number of burns and scalds caused by accidents tends to increase year by year, and the skin of the patient with mild disease is not perfect. Serious people can also become permanently disabled and even life-threatening.

With the rapid development of medical technology, the treatment of common burns and scalds has become a conventional treatment means. However, some medicaments for treating burns and scalds are used for treating symptoms, and are difficult to treat root causes. In addition, the skin grafting technology is adopted, namely, the skin of other parts of the patient is implanted to the burn and scald parts, the mode is suitable for the middle-strength burn patient, however, the technology can not only cause secondary damage to the patient to fill up the affected area, but also mark can be left on the skin surface layer, the skin adaptability and the like are tested.

At present, the conventional medicines for treating burns and scalds are more, such as Jingwanhong, rhubarb tincture, xanthan gum pyrimidine silver and the like, and the medicines have certain curative effect on treating the burns and scalds, but have some defects and problems. The medicine has long cure time, needs to be applied and smeared for many times, and has large dosage, high treatment cost and strong pain feeling when in use.

Disclosure of Invention

In order to solve the problems in the prior art, the invention aims to provide a composition for treating burns and scalds and a preparation method thereof.

The technical scheme adopted by the invention is as follows: the composition for treating burns and scalds is mainly prepared from the following raw materials in parts by mass:

30-180 parts of garden burnet root, 6-30 parts of rhizoma atractylodis and 6-30 parts of borneol.

Sanguisorba officinalis, name of traditional Chinese medicine. Is root of Sanguisorba officinalis L. or Sanguisorba longifolia L. var. longifolia (Bert.) Yu et Li of Sanguisorba genus of Rosaceae family. Has the effects of cooling blood, stopping bleeding, removing toxic substances and healing sore. It can be used for treating hematochezia due to blood heat, hemorrhoidal bleeding, metrorrhagia, scald due to hot water and fire, eczema, pyocutaneous disease, carbuncle, and swelling. Bitter, sour, astringent and slightly cold in nature; it enters liver and large intestine meridians. Chemical components: the radix Sangusorbae contains sanguisorbin I, II, A, B, E, phenolic acid compounds, and small amount of vitaminsAnd (b) element A. The main component for stopping bleeding is tannin. The pharmacological action is as follows: 1. effects on the blood system: the sanguisorba decoction can obviously shorten bleeding and blood coagulation time, and the hemostatic effect of raw sanguisorba is obviously superior to that of sanguisorba charcoal. 2. Astringency to experimental burns and scalds: the sanguisorba officinalis preparation has obvious effects on burn, scald and wound healing, can reduce the permeability of capillary vessels, reduce exudation and relieve tissue edema, and the medicine forms a layer of protective film on the wound surface, has the function of astringing, can reduce skin abrasion and prevent infection. 3. Anti-inflammatory action: sanguisorba can inhibit formoxyl podal swelling and mouse concha swelling induced by croton oil mixture. Has strong inhibitory effect on the increase of skin microvascular permeability caused by prostaglandin E, can inhibit the proliferation of cotton ball granuloma, promote wound healing, and has anti-inflammatory and detumescence effects. 4. Antiemetic action: the sanguisorba decoction has an antiemetic effect on emesis caused by pigeon intravenous injection of digitalis. 5. The antibacterial effect is as follows: the sanguisorba officinalis has inhibition effects on staphylococcus aureus, beta hemolytic streptococcus, pneumococcus, meningococcus and diphtheria, bacilli such as dysentery, large intestine, typhoid, paratyphoid, pyocyanea and the like, and human mycobacterium tuberculosis, and has inhibition effects on certain pathogenic fungi to different degrees. 6. Anti-tumor effect: the tumor inhibition rate of the garden burnet extract liquid is 50 percent. In vitro tests show that the strain has obvious inhibiting effect on human cervical cancer JTC-26. And (3) toxicological effects: in the acute toxicity test, the garden burnet aqueous extract or alcohol extract is used for intragastric administration of 2.5g/kg for mice, and no adverse reaction is found after observation for 7 days; water extraction solution and alcohol extraction solution mouse intraperitoneal injection LD₅₀160 +/-0.29 g/kg and 2.17 +/-0.49 g/kg respectively. Indicating that the sanguisorba officinalis has extremely low oral toxicity. The rats orally take 20ml/kg of water extract every day for 1d, no obvious toxic symptoms are seen, but the fatty infiltration cells are increased compared with the control group when the liver puncture examination is carried out after 5-10d administration.

Rhizoma atractylodis, the name of traditional Chinese medicine. Is dried rhizome of Atractylodes lancea in Atractylodes of Compositae (Thunb.) DC. or Atractylodes chinensis Koidz. Has effects of eliminating dampness, invigorating spleen, dispelling pathogenic wind, and dispelling cold. It can be used for treating syndrome of dampness obstruction in middle energizer, rheumatism, exterior syndrome due to wind-cold-dampness, nyctalopia, and dim and astringent eyes. Pungent, bitter and warm in nature; it enters spleen and stomach meridians. Chemical components: mainly contains volatile oil, and the oil mainly contains atractylol (mixed crystal of beta-eucalyptol and atractylol). The other materials also contain small amount of atractylone, vitamin A-like substance, vitamin B and inulin. The pharmacological action is as follows: the volatile oil of the medicine has obvious effect of resisting intestinal spasm caused by parasympathetic nerve medium acetylcholine; can be used for treating intestinal muscle relaxation caused by sympathetic nerve mediator epinephrine, promoting amplitude recovery of adrenal gland inhibition effect, promoting gastrointestinal motility effect of atractylol, and slightly contracting stomach smooth muscle. The rhizoma atractylodis volatile oil has a sedative effect on the central nervous system in a small dose, and can also promote hyperreflexia of the spinal cord; the large dosage of the composition has inhibitory effect. The rhizoma atractylodis decoction has the function of reducing blood sugar, and has the functions of removing sodium and potassium; the vitamin A-like substance can be used for treating nyctalopia and keratomalacia.

Borneol and the name of traditional Chinese medicine. Is a processed resin product of Dryobalanops aromatica Gaertn.f. of Dryobalanops of Dipterocarpaceae, or a crystal obtained by cutting trunk and branch of Dryobalanops aromatica, distilling and cooling. Has effects of inducing resuscitation, refreshing mind, clearing heat and relieving pain. It can be used for treating block syndrome manifested by unconsciousness, conjunctival congestion, swelling and pain, sore throat, aphtha, sore and ulcer, unhealed sore and ulcer, and scald due to hot water and fire. Pungent and bitter in flavor and slightly cold in nature; it enters heart, spleen and lung meridians. Chemical components: borneol contains dextroborneol, also contains sesquiterpenes such as humulene, beta-elemene, caryophyllene, etc., and triterpenes such as oleanolic acid, hordenic acid, asiatic acid, borneol, coca glycol, etc. The tabellae Blumeae Preparatum contains L-borneol. The machine-made borneol is racemic mixed borneol. The pharmacological action is as follows: 1. effects on the central nervous system: the borneol can prolong the anoxia resisting time, has a calming effect, can improve the permeability of a blood brain barrier, has slight stimulation to sensory nerves by local application, and has a certain pain relieving effect. 2. Antibacterial and anti-inflammatory effects: the borneol with higher concentration has the inhibiting effect on staphylococcus, streptococcus pneumoniae, escherichia coli, part of pathogenic dermatophytes and the like. 3. Other functions are as follows: borneol has the effects of inducing labor in middle and late pregnancy and preventing corrosion.

Preferably, the composition is mainly prepared from the following raw materials in parts by mass:

60-100 parts of garden burnet root, 12-20 parts of rhizoma atractylodis and 12-20 parts of borneol.

80 parts of garden burnet root, 15 parts of rhizoma atractylodis and 15 parts of borneol.

A preparation method of a composition for treating burns and scalds comprises the following steps:

mixing radix Sangusorbae, rhizoma Atractylodis and Borneolum Syntheticum at a certain proportion, soaking, decocting, filtering to remove residue, drying, and sieving to obtain the final product.

Preferably, the soaking is performed by using water;

the soaking time is 30-60 minutes;

the mass ratio of the total mass of the garden burnet, the rhizoma atractylodis and the borneol to the water is 1-2: 5-8.

Preferably, the decoction temperature is 80-120 ℃.

Preferably, the decoction period is 30-55 minutes.

Preferably, the drying is spray drying or freeze drying.

Spray drying is a method for applying systematic technology to material drying. After the thin material is atomized in the drying chamber, the water content is quickly vaporized in the contact of the thin material and hot air, and then the dried product is obtained. The method can directly dry the solution or emulsion into powder or granular product, and can omit the procedures of evaporation, pulverization, etc. The working principle is as follows: the material to be dried is dispersed into fine mist-like particles by mechanical action, and the particles (which increase the water evaporation area and accelerate the drying process) are contacted with hot air to remove most of water instantly, so that the solid matter in the material is dried into powder. The advantages are that: 1. the drying process is very rapid. 2. Can be directly dried into powder. 3. The drying condition is easy to change, and the quality standard of the product is adjusted. 4. Due to the instantaneous evaporation, the equipment material selection requirements are not strict. 5. The drying chamber has a certain negative pressure, so that the sanitary condition in production is ensured, the flying of dust in a workshop is avoided, and the product purity is improved. 6. The production efficiency is high, and operating personnel are few. 7. High productivity and quality of product. The spraying amount per hour can reach hundreds of tons, which is one of the larger treatment capacity of the dryer. 8. The spray dryer is convenient to adjust, and the operating conditions can be changed in a large range to control the quality indexes of the product, such as particle size distribution, moisture content, biological activity, solubility, color, aroma, taste and the like. Spray drying has the characteristics of fast heat transfer, fast water evaporation and short drying time, and the product has good quality, crisp texture and good solubility, can improve the dissolution rate of certain preparations, is suitable for thermosensitive medicaments, and can be used for preparing microcapsules by spray drying. Dye drying is a widely used method. A drying method for atomizing a dye to remove moisture. Is suitable for drying various dyes. Can be used for drying fine powder, superfine powder, dust-free powder and hollow granule of dye. The dye atomization mode can be divided into three types: (1) airflow atomization, namely atomizing feed liquid by using compressed air or water vapor; (2) pressure type atomization, namely extruding the feed liquid from a nozzle at high speed by using a high-pressure pump to form a mist shape; (3) and (3) carrying out rotary atomization, namely adding the feed liquid into a throwing disc (7000-28000 r/min) rotating at a high speed in the atomizer, and quickly throwing the feed liquid out for atomization. The third method has the advantages of good effect, short time, high labor productivity, high equipment investment and high energy consumption, and is favored by the dye industry. The technology has high drying speed. After the feed liquid is centrifugally sprayed, the surface area is greatly increased, 95-98% of water can be instantly evaporated in high-temperature airflow, and the drying time is only a few seconds. The parallel flow type spray drying mode can make the liquid drops and hot air flow in the same direction, and the hot air has higher temperature, but because the hot air is immediately contacted with the spray liquid drops after entering the drying chamber, the indoor temperature is suddenly reduced, and the wet bulb temperature of the material is basically unchanged, so that the method is also suitable for drying the thermosensitive material.

Freeze drying, also known as sublimation drying, is a drying method in which a material is frozen below the freezing point of water, placed in a container under high vacuum (10-40 Pa), and water in the material is directly sublimated from solid ice into water vapor by supplying heat. Freeze drying is the principle of ice crystal sublimation, in a high vacuum environment, water in frozen food materials is directly sublimated from ice solids into steam without ice melting, the water in the vacuum drying materials is generally converted into steam in a liquid state to dry the food, and therefore, freeze drying is also called freeze sublimation drying. Its main advantage is: (1) the freeze drying equipment for the dried material keeps the original chemical composition and physical properties (such as porous structure, colloidal property and the like); (2) the heat consumption is less than other drying methods. The disadvantage is high cost and can not be widely used. Used for drying antibiotics, vegetables and fruits, etc. The water-containing biological sample is frozen and fixed, and the water in the sample is directly sublimated from ice under the condition of low temperature and high vacuum to achieve the aim of drying, and the sample is not deformed under the action of surface tension in the drying process. The dehydration is thorough, the dry product has light weight and small volume, the occupied area is small during storage, and the transportation is convenient; various freeze-dried vegetables were briquetted, and the weight reduction was significant. Due to the reduced volume, the packaging costs are correspondingly much lower. Since vacuum freeze-drying is performed at a low temperature and a low pressure and moisture is directly sublimated, a number of special properties are imparted to the product. For example, vacuum freeze drying can dehydrate heat-sensitive materials thoroughly, and the dried medicine is very stable and convenient for long-term storage. Because the drying of the material is completed in a frozen state, the physical structure and molecular structure of the material are changed little, and the organization structure and appearance form of the material are better preserved compared with other drying methods. In the vacuum freeze drying process, the material has no surface hardening problem, and the material is formed into a porous sponge shape inside, so that the material has excellent rehydration property, and can recover the state before drying in a short time. Because the drying process is carried out at a very low temperature and basically isolates air, the biological, chemical or physical changes of the heat-sensitive substances are effectively inhibited, the active substances in the raw materials are well preserved, and the color and luster of the raw materials are kept.

Preferably, the sieving is performed by using a 1000- & lt1800 & gt mesh sieve.

Preferably, the finished product is an external preparation.

The invention has the beneficial effects that:

the invention provides a composition for treating burns and scalds, which takes garden burnet and rhizoma atractylodis as raw materials, borneol as well as all components matched with each other, thus achieving the purpose of comprehensively treating burns and scalds. The composition has effects of clearing heat and detoxicating, cooling blood and hemostasis, detoxicating and healing sore, resisting bacteria and diminishing inflammation, has effects of promoting wound healing for burn and scald, rapidly relieving swelling and pain, has no addition of any chemical reagent, has no toxic and side effects, and has extremely high cure rate and safety.

The preparation method adopts purification and drying modes to obtain the powdery external preparation, the mode can furthest obtain the effective components in the raw materials, and the particle size of the powder obtained by the mechanical drying mode is smaller, so that the contact surface between the raw materials and the wound is improved, the treatment efficiency is further improved, and the aim of quickly curing the wound is fulfilled.

Detailed Description

The present invention is further illustrated below with reference to specific examples. It will be appreciated by those skilled in the art that the following examples, which are set forth to illustrate the present invention, are intended to be part of the present invention, but not to be construed as limiting the scope of the present invention. The reagents used are all conventional products which are commercially available.

Example 1:

selecting 30 g of garden burnet, 6 g of rhizoma atractylodis and 6 g of borneol according to corresponding proportion, mixing, soaking for 30 minutes by 210 g of water, decocting for 30 minutes at 80 ℃, filtering out residues, drying by a spray dryer, and screening by a 1000-mesh screen to obtain a finished product.

Example 2:

selecting 180 g of garden burnet, 30 g of rhizoma atractylodis and 30 g of borneol according to corresponding proportion, mixing, soaking for 60 minutes by 960 g of water, decocting for 55 minutes at 120 ℃, filtering out residues, drying by a freeze dryer, and screening by a 1800-mesh screen to obtain a finished product.

Example 3:

selecting 60 g of garden burnet, 12 g of rhizoma atractylodis and 12 g of borneol according to corresponding proportion, mixing, soaking for 30 minutes by 420 g of water, decocting for 30 minutes at 120 ℃, filtering out residues, drying by a freeze dryer, and screening by a 1000-mesh screen to obtain a finished product.

Example 4:

100 g of garden burnet, 20g of rhizoma atractylodis and 20g of borneol are selected according to the corresponding proportion, and are mixed, soaked for 60 minutes by 700 g of water, decocted for 55 minutes at 80 ℃, filtered to remove residues, dried by a freeze dryer and sieved by a 1000-mesh sieve to obtain a finished product.

Example 5:

selecting 80 g of garden burnet, 15 g of rhizoma atractylodis and 15 g of borneol according to corresponding proportion, mixing, soaking for 30 minutes by 440 g of water, decocting for 55 minutes at 80 ℃, filtering out residues, drying by a spray dryer, and screening by a 1800-mesh screen to obtain a finished product.

Example 6:

selecting 80 g of garden burnet, 15 g of rhizoma atractylodis and 15 g of borneol according to corresponding proportion, mixing, soaking for 60 minutes by 550 g of water, decocting for 55 minutes at 80 ℃, filtering out residues, drying by a spray dryer, and screening by a 1800-mesh screen to obtain a finished product.

The use method comprises the following steps: the medicine for external use is 20g recommended for each time, once a day, and can be stopped after scabbing.

The operation mode is as follows: cleaning the wound, spraying the medicinal powder, and wrapping.

Clinical cases:

patient 1: lie, woman, age 30.

The disease symptoms are as follows: the skin on the foot surface is scalded due to the broken cup, the red and swollen area is the whole foot surface part, no water bubbles exist, and the second-degree burn is diagnosed.

The product prepared in example 5 above was used for 5 days after exposure therapy and autologous repair without skin grafting.

Patient 2: in certain seasons, men, age 21.

The restaurant waiters are burned by boiling oil when frying and burning meat, the erythema area is large, a plurality of water bubbles exist, the skin is cracked, and the scald of III degree is diagnosed.

The blisters were treated and the finished product prepared in example 5 was used directly to scald the skin surface, the patient had no pain or discomfort the next day, changed the drug once a day, began to scab three days later, and healed 10 days later without scars.

Patient 3: chen certain, male, 19 years old.

For fishing, sunburn in the sun, sunburn of the neck skin, and large red swelling of the back, the finished product prepared in example 5 above disappeared the red swelling after 2 days, and the dead skin was removed after 5 days, and no scar was left.

Patient 4: wu, male, age 22.

When a fire fighting team works, the thigh part is burnt in one fire fighting, a plurality of blisters exist, the red and swollen area is large, and the thigh part is burnt by III degrees.

After the treatment of the blisters, the finished product prepared in example 5 was applied to the burn area and healed after 10 days without scars.

Patient 5: wangzhi, male, 38 years old.

After an electrician in a certain industry uses the finished product prepared in the example 5 to apply the right finger which is carelessly used and electrically shocked, the wounded part is healed after 12 days without scars.

The present invention is not limited to the above alternative embodiments, and any other products in various forms can be obtained by the present invention, and the present invention is within the protection scope of the present invention. The above embodiments should not be construed as limiting the scope of the present invention, and it will be understood by those skilled in the art that modifications may be made to the technical solutions described in the above embodiments, or equivalent substitutions may be made to some or all of the technical features thereof, without departing from the scope of the present invention, and at the same time, such modifications or substitutions may not make the essence of the corresponding technical solutions depart from the scope of the embodiments of the present invention.

Claims

1. The composition for treating burns and scalds is characterized by being mainly prepared from the following raw materials in parts by mass:

2. The composition for treating burns and scalds according to claim 1, wherein the composition is mainly prepared from the following raw materials in parts by mass:

3. The composition for treating burns and scalds according to claim 2, wherein the composition is prepared from the following raw materials in parts by mass:

4. A process for the preparation of a composition for the treatment of burns and scalds according to any one of claims 1 to 3, comprising the following steps:

5. The preparation method of the composition for treating burns and scalds according to claim 4, wherein the soaking is carried out by using water;

the soaking time is 30-60 minutes;

6. The method for preparing a composition for treating burns and scalds according to claim 4, wherein the decoction temperature is 80-120 ℃.

7. The method for preparing a composition for treating burns and scalds according to claim 6, wherein the decoction period is 30-55 minutes.

8. The method for preparing a composition for treating burns and scalds according to claim 4, wherein the drying is spray drying or freeze drying.

9. The method for preparing a composition for the treatment of burn and scald as claimed in claim 4, wherein said sieving is performed with a 1800 mesh sieve of 1000 meshes.

10. The preparation method of the composition for treating burns and scalds according to claim 4, wherein the finished product is an external preparation.