WO2019024678A1 - 血栓去除装置 - Google Patents

血栓去除装置 Download PDF

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Publication number
WO2019024678A1
WO2019024678A1 PCT/CN2018/095855 CN2018095855W WO2019024678A1 WO 2019024678 A1 WO2019024678 A1 WO 2019024678A1 CN 2018095855 W CN2018095855 W CN 2018095855W WO 2019024678 A1 WO2019024678 A1 WO 2019024678A1
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WO
WIPO (PCT)
Prior art keywords
gear
thrombus
tube
suction
assembly
Prior art date
Application number
PCT/CN2018/095855
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English (en)
French (fr)
Inventor
韩建超
张琳琳
樊亚明
丁双喜
史增佐
李中华
苗铮华
Original Assignee
微创心脉医疗科技（上海）有限公司
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Publication date
Application filed by 微创心脉医疗科技（上海）有限公司 filed Critical 微创心脉医疗科技（上海）有限公司
Priority to EP18840326.5A priority Critical patent/EP3662848B1/en
Publication of WO2019024678A1 publication Critical patent/WO2019024678A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/3205—Excision instruments
    • A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/3205—Excision instruments
    • A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
    • A61B17/320758—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions with a rotating cutting instrument, e.g. motor driven
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22038—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with a guide wire
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22079—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with suction of debris
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22084—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance stone- or thrombus-dissolving
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/3205—Excision instruments
    • A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
    • A61B17/320758—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions with a rotating cutting instrument, e.g. motor driven
    • A61B2017/320775—Morcellators, impeller or propeller like means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2217/00—General characteristics of surgical instruments
    • A61B2217/002—Auxiliary appliance
    • A61B2217/005—Auxiliary appliance with suction drainage system

Definitions

  • the invention relates to the technical field of medical instruments, and in particular to a mechanical thrombus removing device.
  • Deep venous thrombosis refers to abnormal blood clotting in the deep veins of the lower extremities, which is a disease of lower extremity venous reflux.
  • DVT Deep venous thrombosis
  • PTS post-thrombotic syndrome
  • PE pulmonary embolism
  • DVT can be treated with oral anticoagulants such as aspirin and warfarin.
  • oral anticoagulants such as aspirin and warfarin.
  • This treatment can inhibit the formation and development of blood clots and reduce the incidence of complications.
  • there are also significant defects in drug treatment For patients with prone to hemorrhage, severe liver and kidney disease, high blood pressure, brain, spinal cord and ophthalmic surgery patients and pregnant women may cause bleeding, and even life-threatening in severe cases.
  • Catheter-directed thrombolysis is another thrombus treatment technique.
  • the thrombolytic drugs such as urokinase and streptokinase are directly infused into the thrombus through a thrombolysis catheter to achieve the purpose of dissolving the thrombus.
  • CDT can restore blood circulation to some extent, relieve or relieve venous obstruction.
  • the treatment efficiency is low and the treatment period is long; the thrombolysis catheter needs to be placed in the patient for a long time, which seriously affects the quality of life of the patient.
  • the large use of thrombolytic drugs increases the risk of bleeding, so CDT is not suitable for patients with high bleeding risk and is not suitable for patients with pregnancy and childbirth.
  • Large-cavity catheter aspiration therapy is to suction the thrombus by the negative pressure provided by the syringe to achieve the purpose of thrombectomy.
  • the treatment device has a simple structure and is convenient to operate; during the operation, the doctor can intuitively feel the suction pressure in the blood vessel, and according to the change of the pressure, the blood clot removal process can be judged.
  • this treatment device has a great defect. When a large thrombus is inhaled in the catheter, the lumen is easily blocked, which seriously affects the efficiency of the thrombectomy.
  • PMT percutaneous mechanical thrombectomy
  • the patents US2014/0088610 A1 and the patent WO2011/024124 A1 respectively disclose a PMT device, the power sources of which both use electrical energy, form a negative pressure in the catheter through physical transformation and suction the thrombus into the lumen.
  • the thrombus is broken into small thrombi and then transported out of the body to achieve the purpose of clearing the thrombus.
  • Both devices are effective in removing blood clots and restoring blood circulation.
  • the above PMT device has the following disadvantages: 1) since the negative pressure fluctuation for aspirating the thrombus is small (substantially constant), when the thrombus outside the catheter adapts to such a pressure and the position is poor, it is difficult to be sucked into the lumen.
  • One of the objects of the present invention is to solve the problem that the large thrombus occludes the lumen in the prior art and affects the efficiency of bolting.
  • Another object of the present invention is to solve the problem that the doctor cannot accurately judge the progress of the operation during the electric suction, and is advantageous for improving the accuracy of the operation.
  • a further object of the present invention is to solve the problem of complicated operation of the active portion of the device.
  • the present invention provides a mechanical thrombus removal device, the mechanical thrombus removal device comprising:
  • the plug head has at least one opening for the thrombus to enter the plug head, and the plug head is connected to the sheath tube;
  • a bolting system comprising an operating component, a gear assembly, a transmission tube and a bolting knife, wherein the operating component drives the transmission tube to rotate through a gear assembly, and the distal end of the transmission tube is connected to the bolt cutter;
  • a snubber system comprising a connecting member, a suction assembly, a drain tube and a liquid inlet tube, one end of the connecting member being connected to the operating assembly, the other end of the connecting member and the suction a component connection, driven by the operating component, the connecting component drives the suction component to form a pressure chamber, the pressure chamber connecting the drain tube and the liquid inlet tube, the inlet tube and the inlet Said sheath connection.
  • the operating component includes a pressing handle and a transmission component, and the transmission component transmits a force of the pressing handle to the gear assembly.
  • the pressure handle comprises a housing and a torsion spring mounted in the housing through a pin, and when the pressing handle releases the pressing force, under the action of the torsion spring , the pressure handle will automatically restore the natural state.
  • the transmission component is a curved rack.
  • the operating assembly includes a rocker and a gear plate, and the gear plate meshes with the gear assembly
  • the gear assembly includes a first bevel gear and a second bevel gear, the first bevel gear meshes with a second bevel gear, and the second bevel gear and the The transmission tube is fixed.
  • the gear assembly further includes a first gear, a second gear, a ratchet and a third gear, and the operating component is engaged with the first gear, the first A gear shares the ratchet with the second gear, the second gear meshes with the third gear, and the third gear is coaxial with the first bevel gear.
  • the suction assembly further includes: a first one-way valve and a second one-way valve, wherein the first one-way valve is disposed on the liquid inlet tube, The second one-way valve is disposed on the liquid discharge pipe.
  • first check valve and the second check valve are disposed in the same direction, such that when one of the first check valve and the second check valve is open, the other is closed.
  • the connecting component is a U-shaped structure, and a U-shaped bottom end connecting rod is connected to the operating component, and an open end of the U-shaped structure is connected to the suction component.
  • the thrombectomy head further includes a sheath connector, and the thrombus system and the suction plug system pass through the sheath connector and the sheath A tube is connected and the transmission tube passes through the sheath connector and is received in the sheath.
  • the fragmentation system further comprises: an adjustable hemostasis valve disposed on the connecting end of the transmission tube.
  • the mechanical thrombus removal device further comprising a thrombolytic system
  • the thrombolysis system comprising a syringe, an infusion tube and a third one-way valve, the infusion tube being connected to the syringe, the first A three-way valve is disposed on the infusion tube, and the syringe injects the thrombolytic drug into the thrombus through the infusion tube to soften or dissolve the thrombus at the thrombus.
  • the suction thrombus system and the thrombus system can be simultaneously driven by a manual operation component, and the large thrombus has been cut into small thrombus by the thrombus system before the thrombus is withdrawn, thereby avoiding the present
  • a large thrombus occludes the lumen and affects the efficiency of the thrombectomy, which improves the success rate of the operation.
  • the manual operation component can intuitively sense the suction pressure in the blood vessel, and can intuitively perceive whether the blood clot is sucked, the blood clot removal process, and the abnormal condition according to the change of the suction pressure, thereby avoiding the prior art.
  • the doctor cannot accurately determine the defects of the surgical procedure and improve the accuracy of the operation.
  • the pressing handle when the pressing handle is pressed, under the action of forming a negative pressure in the suction assembly, the thrombus sucked by the plug is transmitted to the suction assembly through the sheath tube and the inlet tube; When a positive pressure is formed in the suction assembly, the thrombus that has been delivered into the suction assembly is transferred to the collection container through the drainage tube. Since the suction and suction process is completed by pressing the pressure handle, the suction and suction process exhibits a wave suction, and the negative pressure of the wave is used to effectively suck the poorly located thrombus into the lumen and take it out of the body, and the device is simple to operate, and only needs to press the pressure handle. The thrombectomy can be achieved, which further increases the thrombus removal rate.
  • the invention also provides a mechanical thrombus removing device integrating a perfusion thrombolytic drug, a negative pressure suction plug and a mechanical crushing plug, which can significantly accelerate the thrombectomy process, shorten the operation time, reduce the pain of the patient, and expand the operation. Scope of application.
  • FIG. 1 is a schematic structural view of a mechanical thrombus removing device according to a first embodiment of the present invention
  • FIG. 2 is a schematic structural view of a suction plug system according to Embodiment 1 of the present invention.
  • Figure 3 is a cross-sectional view of the suction assembly of Figure 2;
  • FIG. 4 is a schematic structural view of a bolt breaking system according to Embodiment 1 of the present invention.
  • Figure 5 is a partial cross-sectional view showing the plug head of the first embodiment of the present invention.
  • Figure 6 is a cross-sectional view showing the sheath connecting member in the first embodiment of the present invention.
  • Figure 7 is a schematic structural view of a mechanical thrombus removing device according to a second embodiment of the present invention.
  • Figure 8 is a schematic view showing the structure of a gear assembly in the first embodiment of the present invention.
  • Mechanical thrombus removal device 100 suction plug system-1; operating member-1000; pressure handle-1110; housing-1130; torsion spring-1120; connecting member-1310; suction assembly-1320; suction chamber-1321; Liquid chamber - 1322; drain chamber - 1323; pin - 1327; piston - 1326; piston rod - 1325; first check valve - 1324; second check valve - 1324'; drain tube - 1370; -1380; inlet tube-1360; sheath-1340; top hole-1331; side hole-1332; fixing ring-1333; thrombolytic system-2; syringe-1410; third check valve-1420; infusion tube 1430; crushing bolt system-3; transmission component-1210; gear assembly -1200; first gear-1220; second gear-1230; ratchet-1223; first bevel gear-1240; second bevel gear-1250; Gear-1241; transmission tube-1260; front end transmission tube - 1263; intermediate transmission tube - 1262; side hole - 1262a; end end transmission
  • proximal and distal are defined as “distal” generally refers to the end of the medical device that first enters the patient during normal operation, while “proximal” generally refers to the normal operation of the medical device. Approaching the operator's end during the process.
  • FIG. 1 is a schematic structural view of a mechanical thrombus removal device according to the embodiment.
  • the mechanical thrombus removal device 100 includes a bolt removal head 4 , a fragmentation system 3 , and a suction plug system 1 .
  • the bolting head 4 is connected to the sheath tube 1340.
  • the fragmentation system 3 includes an operation assembly 1000, a gear assembly 1200, a transmission tube 1260, and a fragmentation knife 1270.
  • the operation assembly drives the transmission tube 1260 to rotate through the gear assembly 1200. Connect the Broken Knife 1270 to the distal end.
  • the operation assembly 1000 includes, for example, a pressing handle 1110 and a transmission member 1210 that transmits the force of the pressing handle 1110 to the gear assembly 1200.
  • the suction plug system 1 includes a connecting member 1310, a suction assembly 1320, a drain tube 1370, and a liquid inlet tube 1360, one end of the connecting member 1310 is connected to the operating assembly, following the The operation component is interlocked, and the other end of the connecting component 1310 is connected to the suction component 1320.
  • the connecting component 1310 drives the suction component 1320 to form a pressure chamber, and the pressure chamber connects the drain pipe 1370 and the The inlet tube 1360 is described, and the inlet tube 1360 is coupled to the sheath 1340.
  • one end of the drain tube 1370 is in communication with the suction assembly 1320, and the other end of the drain tube 1370 is in communication with a collection container 1380, one end of the inlet tube 1360 and the The suction assembly 1320 is in communication, the other end of the inlet tube 1360 is coupled to one end of the sheath 1340, and the other end of the sheath 1340 is coupled to the plucking head 4.
  • the collection container 1380 is preferably a collection bag or collection bin.
  • FIG. 5 is a partial cross-sectional view of the plug head 4 in the embodiment.
  • the bolting head 4 is connected to the sheath tube 1340 through a fixing ring 1333 having a top hole 1331 and a side hole 1332 for conveying a thrombolytic drug, the side hole 1332 is used to aspirate the thrombus.
  • the position of the side hole 1332 corresponds to the position of the bobbin blade 1270 such that the inhalation of the thrombus in the tethering head 4 through the side hole 1332 is directly shredded by the bobbin blade tip 1271 of the shredder blade.
  • the suction assembly 1320 includes a suction chamber 1321, a piston 1326, and a piston rod 1325.
  • the piston 1326 is sleeved on the outer side of the piston rod 1325 and is inscribed.
  • an end of the piston rod 1325 away from the piston 1326 is connected to the connecting member 1310; when the operating assembly is stressed, the pressure chamber is under negative pressure, and when the operating assembly is not subjected to force, the pressure The cavity is positive pressure.
  • the pressing handle 1110 sequentially drives the connecting member 1310, the piston rod 1325, and the piston 1326 to be disengaged from the suction chamber 1321.
  • the direction is moved to form a negative pressure in the suction chamber 1321;
  • the pressing handle 1110 releases the pressing force, under the action of the torsion spring 1120, the pressing handle 1110 automatically returns to the natural state, thereby sequentially driving
  • the connecting member 1310, the piston rod 1325, and the piston 1326 move in a direction to enter the suction chamber 1321 to form a positive pressure in the suction chamber 1321.
  • the structure of the suction assembly 1320 includes, but is not limited to, the structure shown in FIG. 3, as long as the suction assembly 1320 can change the internal pressure of the suction chamber 1321 under the action of the pressing force of the pressing handle 1110, thereby in the suction assembly.
  • a negative pressure is formed in the 1320 to meet the pressure requirement for aspiration of the thrombus.
  • the suction assembly 1320 when the suction assembly 1320 is in operation, each time is only in a state of suction and discharge, since the suction assembly 1320 and the drain tube 1370 and the inlet tube 1360 are both connected, in order to control the suction assembly 1320 In the flow direction of the liquid, the suction assembly 1320 further includes: a first one-way valve 1324 and a second one-way valve 1324', the first one-way valve 1324 is disposed on the liquid inlet tube 1360, the second A check valve 1324' is disposed on the drain pipe 1370.
  • the first check valve 1324 When a negative pressure is formed in the suction assembly 1320, the first check valve 1324 is opened under the action of the negative pressure, the second check valve 1324' is closed, and the thrombus inhaled by the plug head 4
  • the sheath tube 1340, the inlet tube 1360 is transferred into the suction chamber 1321 (ie, the suction assembly 1320 is in a suction state);
  • the first one-way valve 1324 is closed, the second one-way valve 1324' is opened, and the thrombus that has been transferred into the suction chamber 1321 is transmitted to the collection container 1380 through the liquid discharge tube 1370 ( That is, the suction assembly 1320 is in a draining state).
  • the first check valve 1324 and the second check valve 1324' are both umbrella valves;
  • the suction chamber 1321 is a housing structure and has a liquid inlet chamber 1322 and a liquid discharge chamber 1323,
  • the liquid inlet chamber 1322 is in communication with the liquid inlet tube 1360 (the liquid inlet tube 1360 can be adhered to the outside of the liquid inlet chamber 1322 by glue bonding), and the liquid discharging chamber 1323 and the liquid discharging tube 1370 Connected (the liquid discharge pipe 1370 can be glued to the outside of the liquid discharge cavity 1323), and the liquid inlet cavity 1322 and the liquid discharge cavity 1323 each have a boss, and the umbrella valve is separately installed.
  • the umbrella valve in the liquid inlet chamber 1322 and the umbrella valve in the liquid discharge chamber 1323 are disposed in the same direction, and therefore, the umbrella valve in the liquid discharge chamber 1323 when the umbrella valve in the liquid inlet chamber 1322 is opened It will automatically shut down under internal pressure and vice versa.
  • the specific structure of the connecting component 1310 may be two, as follows.
  • the connecting member 1310 is a connecting rod, one end of the connecting rod is connected to the pressing handle 1110 through a pin shaft, and the other end of the connecting rod passes through the body wall of the suction chamber 1321.
  • the piston rod 1325 is connected. When the pressing handle 1110 is pressed, the piston rod 1325 will be moved by the connecting rod.
  • the above structure has the advantage of simple structure, but there may be a disadvantage in that, since the connecting rod is a rod-shaped body, the connecting rod drives the piston rod 1325 connected thereto in the horizontal direction and the vertical direction under the force of the pressing handle 1110. The directions are all displaced, so there is a relative horizontal movement between the piston 1326 and the suction chamber 1321, which is detrimental to the sealing effect of the piston 1326 in the suction chamber 1321, increasing wear on the piston 1326 and the suction chamber 1321.
  • the connecting member 1310 is a U-shaped structure, and the bottom end connecting rod of the U-shaped structure is connected with the pressing handle 1110, and the open end of the U-shaped structure is connected with the suction assembly 1320 ( Specifically, it passes through the body wall of the suction chamber 1321 and is connected to the piston rod 1325 through the pin 1327).
  • the second structure overcomes the possible problem of the structure.
  • the open end of the U-shaped structure passes through the body wall of the suction chamber 1321 and is connected to the piston rod 1325 through the pin 1327, so that the piston rod 1325 can be penetrated.
  • the pin end 1327 of the open end of the U-shaped structure moves horizontally, while the piston 1326 does not have a horizontal displacement relative to the suction chamber 1321, avoiding friction between the piston 1326 and the body wall of the suction chamber 1321.
  • the advantage of the U-shaped structure of the technical solution is that the piston rod is not subjected to the torsion when it is moving, and its direction of force is always on the axis of the suction chamber.
  • the pressing handle 1110 includes a housing 1130 and a torsion spring 1120 mounted in the housing 1130 through a pin.
  • the press shank 1110 automatically returns to its natural state.
  • the mechanical thrombus removal device may further include a thrombolysis system 2.
  • the thrombolysis system 2 includes a syringe 1410, an infusion tube 1430, and a third one-way valve 1420.
  • the infusion tube 1430 is connected to the syringe 1410, and the third one-way valve 1420 is disposed on the infusion tube 1430.
  • the syringe 1410 infuse the loaded thrombolytic drug through the infusion tube 1430 to the thrombus site, and softens or dissolves the thrombus at the thrombus site.
  • the purpose of the third check valve 1420 is to prevent backflow of the thrombolytic drug in the infusion tube 1430 and to achieve a one-way flow of the thrombolytic drug from the syringe 1410 to the infusion tube 1430.
  • the fragmentation system 3 further includes a transmission tube end connector 1280 and an adjustable hemostasis valve (not shown in FIG. 4) disposed on the transmission tube end connector 1280.
  • one end of the transmission member 1210 is fixedly coupled to the press shank 1110, and the other end of the transmission member 1210 is engaged with the gear assembly 1200, one end of the transmission tube 1260 and the transmission
  • the tube end connector 1280 is coupled, and the other end (distal end) of the transmission tube 1260 is fixedly coupled to the bobbin blade 1270 and housed in the sheath 1340; the transmission member 1210 will press the pressure
  • the force of the shank 1110 is transmitted to the gear assembly 1200, and the gear assembly 1200 transmits a rotational motion to the transmission tube 1260 under the force of the shank 1110, and the transmission tube 1260 drives the broaching knife 1270 rotation, the thrombus that has been inhaled into the plug head 4 is broken.
  • the transmission member 1210 is preferably a rack, more preferably a curved rack.
  • the gear assembly 1200 includes a first bevel gear 1240 and a second bevel gear 1250.
  • the first bevel gear 1240 meshes with a second bevel gear 1250, and the second bevel gear 1250 and the transmission Tube 1260 is fixed.
  • the gear assembly further includes a first gear 1220, a second gear 1230, a ratchet 1223 and a third gear 1241, the transmission member 1210 is meshed with the first gear 1220, the first gear 1220 and the The second gear 1230 shares the ratchet 1223, the second gear 1230 meshes with the third gear 1241, the third gear 1241 is coaxial with the first bevel gear 1240, and the second bevel gear 1250 is The first bevel gear 1240 is engaged.
  • the transmission member 1210 fixedly connected to the pressing handle 1110 moves to the lower right of the figure, and the breaking bolt transmission member 1210 drives the first gear 1220 to rotate counterclockwise, and the first gear 1220 drives the first gear 1220.
  • the second gear 1230 rotates counterclockwise, the second gear 1230 drives the first bevel gear 1240 to rotate by the third gear, the first bevel gear 1240 drives the second bevel gear 1250 to rotate, and the second bevel gear 1250 drives the transmission tube 1260 to rotate.
  • the tube 1260 drives the bobbin cutter 1270 to rotate.
  • the transmission member 1210 fixedly connected to the pressing handle 1110 moves to the upper left of the figure, and the transmission member 1210 drives the first gear 1220 to rotate clockwise.
  • the second gear 1230 It is not rotated by the rotation of the first gear 1220, that is, the rotation of the first gear 1220 is cut off at the ratchet 1223, and the second gear 1230, the first bevel gear 1240, the second bevel gear 1250, and the transmission tube 1260 are not rotated. .
  • the fragmentation system 4 and the suction plug system 1 are both connected to the sheath 1340 through the sheath connector 1350 , and the transmission tube 1260 passes through the sheath connector 1350 . And is housed in the sheath 1340.
  • one end of the sheath connecting member 1350 is connected to an end of the sheath tube 1340 away from the bolt removing head 4.
  • the connection between the sheath 1340 and the thrombus system 1, the thrombolytic system 2, and the fragmentation system 3 is achieved by a sheath connector 1350.
  • the transmission tube 1260 includes: a front end transmission tube 1263, an intermediate transmission tube 1262, and a tail end transmission tube 1261 that are sequentially connected; wherein the front end transmission tube 1263 and the end end transmission tube 1261 are single layers or a hollow tubular member of a multi-layer composite pipe; the front end transmission pipe 1263 and the tail end transmission pipe 1261 may comprise a metal braid layer and an inner liner layer when the multi-layer composite pipe material is; the intermediate transmission pipe 1262 has at least one side The hole 1262a (see FIG.
  • the liquid entering the sheath connector 1350 enters the intermediate transmission tube 1262 through the side hole 1262a; the fragment knife 1270 is fixed to the front end transmission tube 1263 and is accommodated In the sheath tube 1340, the intermediate transmission tube 1262 is received in the sheath connecting member 1350, and the end end transmission tube 1261 is away from one end of the intermediate transmission tube 1262 and the transmission tube end connecting member 1280.
  • the second bevel gear 1250 is sleeved outside the tail end transmission pipe 1261 (in other words, the tail end transmission pipe 1261 passes through the center hole of the second bevel gear 1250 and the second bevel gear 1250 fixedly connected so that the second bevel gear 1 When the 250 rotates, the tail end transmission pipe 1261 rotates accordingly, thereby driving the bolt cutter 1270 fixed to the front end transmission pipe 1263 to rotate, and performing the bolting work).
  • the sheath connector 1350 is designed to include: a total connector 1350a, with the total connection a second furcation connector 1350c and a third furcation connector 1350d that communicate with one end of the member 1350a, and a first furcation connector 1350b that communicates with the other end of the total connector 1350a, wherein the total connector The other end of 1350a is also in communication with the sheath 1340.
  • the inlet tube 1360 is connected to the sheath tube 1340 by the first branching connection 1350b; the fragmentation system 3 is passed through the second branching connection 1350c
  • the sheath tube 1340 is connected; in the thrombolysis system 2, the infusion tube 1430 communicates with the sheath tube 1340 through the third furcation link 1350d, and is delivered to the sheath tube 1340 through the infusion tube 1430.
  • a liquid, such as a thrombolytic drug, can enter the transmission tube through side holes 1262a in the intermediate transmission tube 1262.
  • each component can be fabricated by machining, injection molding, extrusion, and laser engraving; the fixed connection between the different components can be laser welded or glued.
  • the connecting manner for example, the front end transmission tube 1263, the intermediate transmission tube 1262 and the end end transmission tube 1261 are sequentially welded by laser to form a transmission tube, and the bobbin knife 1270 is fixed to the front end transmission tube 1263 by laser welding. Since the manner of preparation and assembly of the components does not involve the focus of the technical solution of the present invention, no further details are provided herein.
  • the plug head 4 Before the start of the operation, the plug head 4 is placed in the physiological saline, and when the pressure handle 1110 is manually pressed until the physiological saline is visible in the collection container 1380, the pressing of the pressing handle 1110 is stopped, and the syringe 1410 is connected to the third one-way valve 1420 for suction.
  • the suction is stopped when physiological saline is visible in the syringe 1410, and the air in the mechanical thrombus removal device is evacuated.
  • the principle of action of the suction assembly 1320 when the pressure handle 1110 is manually pressed before the start of surgery is the same as when the pressure handle 1110 is manually pressed during the following surgery.
  • the blood vessel is punctured, and the mechanical thrombus removal device reaches the thrombus along the guide wire (outsourced). Specifically, the sheath 1340 and the plug head 4 are all entered into the patient, and the rest of the structure is outside the patient's body. Reach the thrombus.
  • the thrombolysis process after the syringe 1410 is sucked with the thrombolytic drug, it is connected with the third one-way valve 1420, and the syringe 1410 is pressed, and the thrombolytic drug is sequentially injected into the intermediate transmission through the side hole 1262a of the infusion tube 1430 and the intermediate transmission tube 1262.
  • the suction bolt and the bolt are pressed, and the pressing handle 1110 is pressed.
  • the gear assembly 1200 transmits the rotary motion to the transmission tube under the action of the pressing handle 1110, and then the transmission tube drives the fragment cutting knife 1270 to rotate; meanwhile, the pressing handle 1110 is connected.
  • the member 1310 and the piston rod 1325 drive the piston 1326 to suction and discharge in the suction chamber 1321.
  • the piston 1326 moves outward from the suction chamber 1321, and the suction assembly 1320 performs suction; when the pressing handle 1110 is released, the piston 1326 moves into the suction chamber 1321, and the suction assembly 1320 performs Drain. Since the umbrella valve in the liquid inlet chamber 1322 is disposed in the same direction as the umbrella valve in the liquid discharge chamber 1323, the umbrella valve in the liquid discharge chamber 1323 is automatically operated by internal pressure when the umbrella valve in the liquid inlet chamber 1322 is opened. Close and vice versa.
  • the umbrella valve in the liquid inlet chamber 1322 is opened, the umbrella valve in the liquid discharge chamber 1323 is closed, and the passage formed by the suction chamber 1321, the inlet chamber 1322, the inlet tube 1360, and the sheath tube 1340 is under negative pressure.
  • the thrombus is sucked into the inside of the plug head 4 through the side hole 1332 of the plug head 4, and the rotating chip cutter blade 1271 and the side hole 1332 of the plug head 4 cooperate to chop the inhaled internal thrombus, and at the same time, under the negative pressure
  • the chopped thrombus is sucked into the suction chamber 1321; when draining, the umbrella valve in the liquid inlet chamber 1322 is closed, the umbrella valve in the liquid discharge chamber 1323 is opened, the suction chamber 1321, the liquid discharge chamber 1323,
  • the passage formed by the drain tube 1370 expels the shredded thrombus under positive pressure and is delivered to the collection container 1380.
  • the present embodiment is different from the first embodiment in that the operating assembly 1000 includes a rocker 1140 and a gear plate 1231.
  • the rocker 1140 is located at one side of the gear plate 1231 and is connected by a shaft.
  • the gear plate 1231 is meshed with the third gear 1241.
  • the third gear 1241 is coaxial with the first bevel gear 1240.
  • the first bevel gear 1240 and the second bevel gear 1250 meshed.
  • each component can be fabricated by machining, injection molding, extrusion, and laser engraving.
  • the fixed connection between the different components may be by laser welding or glue bonding.
  • the front end transmission pipe 1263, the intermediate transmission pipe 1262 and the end end transmission pipe 1261 are sequentially welded by laser to form the transmission pipe 1260.
  • the proximal end of the intermediate transmission tube 1262 is welded to the tail end transmission tube 1261, the intermediate transmission tube 1262 is placed in the sheath connection member 1350, and one end of the end end transmission tube 1261 is passed through.
  • the second bevel gear 1250 is bored and connected by laser welding, and the other end of the tail end transmission pipe 1261 is mounted in the transmission pipe end connection 1280.
  • the cleaver blade 1270 is fixed to the front end transmission tube 1263 by laser welding and placed in the sheath tube 1340.
  • the connecting rod 1311 is hinged on the other side of the gear plate 1231, one end of the slider 1312 is hinged to the connecting rod 1311, and the other end is connected to the piston rod 1325 through the pin. 1327 connection.
  • the first one-way valves 1324, 1324' are respectively mounted on the bosses in the liquid inlet chamber 1322 and the liquid discharge chamber 1323, and are kept in the same direction.
  • One end of the drain pipe 1370 is mounted at the outer end of the drain chamber 1323 and bonded with glue, and the other end is mounted on the collecting container 1380.
  • One end of the inlet tube 1360 is mounted at the outer end of the inlet chamber 1322 and bonded with glue, and the other end is mounted on the first bifurcated connection 1350b of the sheath connector 1350.
  • the proximal end of the plucking head 4 and one end of the fixing ring 1333 are laser welded.
  • the distal end of the sheath 1340 and the other end of the retaining ring 1333 are bonded by glue, and the proximal end of the sheath 1340 is bonded to the sheath connecting member 1350 by glue.
  • one end of the infusion tube 1430 is adhered to the third bifurcated connector 1350d of the sheath connecting member 1350 by glue, and the third one-way valve 1420 is adhered to the other end of the infusion tube 1430 by glue.
  • the syringe 1410 is secured to the third one-way valve 1420 to form a complete mechanical thrombus removal device 100.
  • the plug head 4 Before the start of the operation, the plug head 4 is placed in the physiological saline, and when the rocker 1140 is rotated counterclockwise until the physiological saline is visible in the collection container 1380, the rocker 1140 is stopped, and the syringe 1410 is connected to the check valve 1420 for suction. When the physiological saline is visible in the syringe 1410, the suction is stopped, and the air in the ejection device is emptied.
  • the principle of action of the aspiration assembly 1320 when the rocker 1140 is rotated prior to the start of surgery is the same as when the rocker 1140 is rotated during the following procedure.
  • the blood vessel is punctured, and the thrombectomy device is taken along the guide wire (outsourced) to the thrombus site.
  • the sheath 1340 and the plug head 4 are all entered into the patient, and the rest of the structure is outside the patient, and the syringe 1410 is sucked.
  • the thrombolytic drug is connected with the one-way valve 1420, the syringe 1410 is pressed, and the thrombolytic drug is sequentially injected into the inner cavity of the intermediate transmission tube 1262 through the infusion tube 1430 and the intermediate transmission tube side hole 1262a, and the front end transmission tube 1263 is the inner cavity.
  • the top hole 1331 reaches the thrombus site, and the thrombolytic agent softens or dissolves after contacting the thrombus.
  • the rocker 1140 is rotated counterclockwise, and the gear system composed of the gear plate 1231, the third gear 1241, the first bevel gear 1240 and the second bevel gear 1250 transmits the rotary motion to the transmission tube 1260 under the action of the rocker 1140.
  • the drive tube 1260 then drives the bobbin cutter 1270 to rotate; at the same time, the rocker 1140 drives the piston 1326 to pump and drain in the suction chamber 1321 through the gear plate 1231, the connecting rod 1311, the slider 1312 and the piston rod 1325.
  • the piston 1326 moves outward from the suction chamber 1321, and the suction assembly 1320 performs suction; when the rocker 1140 rotates counterclockwise for the second half, the piston 1326 moves into the suction chamber 1321.
  • the suction assembly 1320 performs drainage. Since the one-way valve of the liquid inlet chamber 1322 and the one-way valve of the liquid discharge chamber 1323 are disposed in the same direction, the one-way valve of the liquid discharge chamber 1323 is automatically opened by the internal pressure when the one-way valve of the liquid inlet chamber 1322 is opened. Close and vice versa.
  • the one-way valve of the liquid inlet chamber 1322 is opened, the one-way valve of the liquid discharge chamber 1323 is closed, and the passage formed by the suction chamber 1331, the inlet chamber 1322, the inlet tube 1360, and the sheath tube 1340 is under negative pressure.
  • the thrombus is sucked into the inside of the plug head 4 through the side hole 1332 of the plug head, and the rotating chip cutter blade 1271 and the plug head side hole 1332 cooperate to chop the inhaled thrombus, and at the same time, under the action of negative pressure, cut
  • the broken thrombus is sucked into the chamber of the suction chamber 1331; when draining, the one-way valve of the liquid inlet chamber 1322 is closed, the one-way valve of the liquid discharge chamber 1323 is opened, the suction chamber 1331, the liquid discharge chamber 1323, and the liquid discharge tube
  • the passage formed by 1370 expels the shredded thrombus under positive pressure and delivers it to collection container 1380.
  • the mechanical thrombus removal device of the present invention has the following beneficial effects:
  • the device is easy to operate, just press the pressure handle or shake the rocker to achieve the bolt. The doctor can put more energy into the patient's treatment.

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Abstract

一种血栓去除装置（100），通过一个手动操作组件（1000）可以同时带动吸栓系统（1）和碎栓系统（3），在将血栓抽出之前就已经通过碎栓系统（3）将大血栓切割为小血栓，避免了现有技术中大块血栓堵塞管腔而影响取栓效率的缺陷，提高了手术的成功率。另一方面，手动操作组件（1000）可以直观感受到血管内的抽吸压力，根据抽吸压力的变化即可直观的感知到是否抽吸到血栓、血栓的清除进程以及异常情况，避免了现有技术中电动抽吸时医生无法准确判断手术进程的缺陷，提高了手术的精确度。

Description

血栓去除装置 技术领域
本发明涉及医疗器械技术领域，特别涉及一种机械血栓去除装置。
背景技术
下肢深静脉血栓(deep venous thrombosis，DVT)是指血液非正常地在下肢深静脉内凝结，属于下肢静脉回流障碍性疾病。DVT并发症主要有两种：血栓形成初期没有得到及时治疗，可形成血栓后综合征(post thrombosis syndrome，PTS)，其表现为下肢水肿，肌肉疼痛，色素沉着，皮下组织纤维变化，重者形成局部溃疡；血栓脱落随血液冲击到达肺动脉，可引起肺栓塞(pulmonary embolism，PE)，PE诊断率低，误诊率和病死率高。
DVT初期可通过口服阿司匹林、华法林等抗凝药进行治疗。这种治疗方法能够抑止血栓的形成及发展，降低并发症的发生率。然而药物治疗也存在显著的缺陷，对于易出血体质，严重肝肾疾病，高血压，脑、脊髓及眼科手术患者和孕妇等可能会造成机体出血，严重时甚至危及生命。
置管溶栓(catheter-directed thrombolysis，CDT)是另一种血栓治疗技术，通过溶栓导管把溶栓药如尿激酶、链激酶等直接灌注到血栓部位，达到溶解血栓的目的。CDT可以在一定程度上恢复血液循环，解除或缓解静脉梗阻。但是治疗效率低，治疗周期长；溶栓导管需要长时间放置在患者体内，严重影响患者的生活质量。此外，大量使用溶栓药物会增加出血风险，所以，CDT不适用于出血风险高的患者，不适合妊娠和分娩的患者。
对于症状比较严重，无法使用抗凝药和溶栓药的患者，可以采用传统手术的方法进行治疗。然而，这种方法会给患者造成较大的创口；手术后，患者的疼痛大，恢复慢，住院时间长。此外，一般状况较差的患者不适合采用传统手术治疗。
大腔导管抽吸治疗是通过注射器提供的负压对血栓进行抽吸，达到取栓的目的。这种治疗装置的结构简单，操作方便；在手术过程中，医生可以直观的感受到血管内的抽吸压力，根据这种压力的变化可以判断出血栓的清除 进程。但这种治疗装置存在很大的缺陷，当导管内吸入大块血栓时，易造成管腔堵塞，严重影响取栓效率。
随着技术的发展，近年来出现的机械血栓清除(percutaneous mechanical thrombectomy，PMT)装置越来越得到医生和患者的青睐。PMT是一种微创伤介入治疗方法，通过溶解、破碎和抽吸等方式高效的去除血栓，以恢复血液循环。
专利US2014/0088610 A1和专利WO2011/024124 A1分别公开了一种PMT装置，这两种装置的动力源均采用电能，通过物理转化在导管内形成负压并对血栓进行抽吸，吸入管腔内的血栓被破碎成小血栓，然后输送出体外，达到清除血栓的目的。这两种装置都可以有效的清除血栓，恢复血液循环。但是，上述PMT装置存在以下不足：1)由于用于抽吸血栓的负压波动很小(基本恒定)，当导管外的血栓适应这种压力且位置不佳时，就很难被吸入管腔，导致血管内的残留血栓较多，导致血栓取出率低；2)在装置开启后，系统自动从血管内抽吸和破碎血栓，医生无法直观的感知到是否抽吸到血栓，血栓的清除进程以及异常情况；3)装置的有源部分操作复杂，医生在手术过程中需要同时兼顾机器和病人，无法投入更多的精力在患者的治疗方面。
针对现有的机械血栓清除装置的不足，本领域技术人员一直在寻找解决的方法。
发明内容
本发明的目的之一在于，解决现有技术中大块血栓堵塞管腔而影响取栓效率的问题。
本发明的另一目的在于，解决电动抽吸时医生无法准确判断手术进程的问题，有利于提高手术的精确度。
本发明的再一目的在于，解决装置的有源部分操作复杂的问题。
为解决上述技术问题，本发明提供一种机械血栓去除装置，所述机械血栓去除装置包括：包括:
取栓头，具有供血栓进入所述取栓头的至少一个开孔，且所述取栓头连 接鞘管；
碎栓系统，包括操作组件、齿轮组件、传动管以及碎栓刀,所述操作组件通过齿轮组件带动传动管旋转，所述传动管的远端连接碎栓刀；
吸栓系统，所述吸栓系统包括连接部件、抽吸组件、排液管以及进液管，所述连接部件的一端与所述操作组件连接，所述连接部件的另一端与所述抽吸组件连接，在所述操作组件的驱动下，所述连接部件带动所述抽吸组件形成压力腔，所述压力腔连接所述排液管及所述进液管，所述进液管与所述鞘管连接。
可选的，所述操作组件包括压柄以及传动部件，所述传动部件将所述压柄的作用力传递给所述齿轮组件。
可选的，在所述的机械血栓去除装置中，所述压柄包括壳体及通过销轴安装于壳体内的扭簧，所述压柄解除按压力时，在所述扭簧的作用下，所述压柄会自动恢复自然状态。
可选的，在所述的机械血栓去除装置中，所述传动部件为弧形齿条。
可选的，在所述的机械血栓去除装置中，所述操作组件包括摇杆以及齿轮盘，所述齿轮盘与所述齿轮组件啮合
可选的，在所述的机械血栓去除装置中，所述齿轮组件包括第一锥齿轮及第二锥齿轮，所述第一锥齿轮与第二锥齿轮啮合，所述第二锥齿轮与所述传动管固定。
可选的，在所述的机械血栓去除装置中，所述齿轮组件还包括第一齿轮、第二齿轮、棘轮和第三齿轮，所述操作组件与所述第一齿轮啮合，所述第一齿轮与所述第二齿轮共用所述棘轮，所述第二齿轮与所述第三齿轮啮合，所述第三齿轮与所述第一锥齿轮共轴。
可选的，在所述的机械血栓去除装置中，所述抽吸组件包括抽吸室、活塞及活塞杆，所述活塞套接于活塞杆的外侧，并内切于所述抽吸室，所述活塞杆远离活塞的一端与所述连接部件连接；所述操作组件受力时，所述压力腔内产生负压，所述操作组件不受力时，所述压力腔内产生正压。
可选的，在所述的机械血栓去除装置中，所述抽吸组件还包括：第一单 向阀及第二单向阀，所述第一单向阀设置于所述进液管上，所述第二单向阀设置于所述排液管上。
可选的，所述第一单向阀和所述第二单向阀的设置方向相同，使得所述第一单向阀和所述第二单向阀中的一个打开时，另一个关闭。
可选的，在所述的机械血栓去除装置中，所述连接部件为U型结构，U型结构底端连接杆与所述操作组件连接，U型结构的开口端与所述抽吸组件连接。
可选的，在所述的机械血栓去除装置中，所述取栓头还包括一鞘管连接件，所述碎栓系统及所述吸栓系统均通过所述鞘管连接件与所述鞘管连接，所述传动管穿过所述鞘管连接件并容置于所述鞘管中。
可选的，在所述的机械血栓去除装置中，所述碎栓系统还包括：设置于传动管尾端连接件上的可调止血阀。
可选的，在所述的机械血栓去除装置中，还包括溶栓系统，所述溶栓系统包括注射器、输液管及第三单向阀，所述输液管与所述注射器连接，所述第三单向阀设置于所述输液管上，所述注射器将承载的溶栓药物通过输液管灌注到达血栓部位，对血栓部位的血栓进行软化或溶解。
在本发明所提供的机械血栓去除装置中，通过一个手动操作组件可以同时带动吸栓系统和碎栓系统，在将血栓抽出之前就已经通过碎栓系统将大血栓切割为小血栓，避免了现有技术中大块血栓堵塞管腔而影响取栓效率的缺陷，提高了手术的成功率。
另一方面，手动操作组件可以直观感受到血管内的抽吸压力，根据抽吸压力的变化即可直观的感知到是否抽吸到血栓、血栓的清除进程以及异常情况，避免了现有技术中电动抽吸时医生无法准确判断手术进程的缺陷，提高了手术的精确度。
另一方面，利用压柄受到按压力时，在抽吸组件内形成负压的作用下，取栓头吸入的血栓经鞘管、进液管被传输至抽吸组件内；压柄解除按压力时，抽吸组件内形成正压的作用下，已传输至抽吸组件内的血栓通过排液管传输至收集容器内。由于吸栓过程通过按压压柄完成，吸栓过程呈现波动式抽吸， 利用波动的负压把位置不佳的血栓有效的吸入管腔并取出体外，且装置操作简单，只需按压压柄即可实现取栓，进一步提高了血栓取出率。
另一方面，本发明还提供了集灌注溶栓药物、负压吸栓、机械碎栓于一体的机械血栓清除装置，可以显著加速取栓过程，缩短手术时间，减轻患者痛苦，也扩大了手术适用范围。
附图说明
图1是本发明实施例一中机械血栓去除装置的结构示意图；
图2是本发明实施例一中吸栓系统的结构示意图；
图3是图2中抽吸组件的剖面示意图；
图4是本发明实施例一中碎栓系统的结构示意图；
图5是本发明实施例一中取栓头的局部剖面示意图；
图6是本发明实施例一中鞘管连接件的剖面示意图；
图7是本发明实施例二中机械血栓去除装置的结构示意图；
图8是本发明实施例一中齿轮组件的结构示意图。
图中：
机械血栓去除装置100；吸栓系统-1；操作部件-1000；压柄-1110；壳体-1130；扭簧-1120；连接部件-1310；抽吸组件-1320；抽吸室-1321；进液腔-1322；排液腔-1323；销轴-1327；活塞-1326；活塞杆-1325；第一单向阀-1324；第二单向阀-1324’；排液管-1370；收集容器-1380；进液管-1360；鞘管-1340；顶孔-1331；侧孔-1332；固定环-1333；溶栓系统-2；注射器-1410；第三单向阀-1420；输液管-1430；碎栓系统-3；传动部件-1210；齿轮组件-1200；第一齿轮-1220；第二齿轮-1230；棘轮-1223；第一锥齿轮-1240；第二锥齿轮-1250；第三齿轮-1241；传动管-1260；前端传动管-1263；中间传动管-1262；侧孔-1262a；尾端传动管-1261；传动管尾端连接件-1280；碎栓刀-1270；碎栓刀刀锋-1271；取栓头-4；鞘管连接件-1350；总连接件-1350a；第一分叉连接件-1350b；第二分叉连接件-1350c；第三分叉连接件-1350d；齿轮盘-1231；连接杆-1311；滑块-1312。
具体实施方式
以下结合附图和具体实施例对本发明提出的机械血栓去除装置作进一步详细说明。根据下面说明和权利要求书，本发明的优点和特征将更清楚。需说明的是，附图均采用非常简化的形式且均使用非精准的比例，仅用以方便、明晰地辅助说明本发明实施例的目的。
本文中“近端”和“远端”的定义为：“远端”通常指该医疗设备在正常操作过程中首先进入患者体内的一端，而“近端”通常是指该医疗设备在正常操作过程中靠近操作者的一端。
实施例一
请参考图1，其为本实施例中机械血栓去除装置的结构示意图，如图1所示，所述机械血栓去除装置100包括取栓头4、碎栓系统3以及吸栓系统1，所述取栓头4连接鞘管1340。
重点参考图4所示，其为本实施例中碎栓系统3的结构示意图。如图4所示，所述碎栓系统3包括操作组件1000、齿轮组件1200、传动管1260及碎栓刀1270，所述操作组件通过齿轮组件1200带动传动管1260旋转，所述传动管1260的远端连接碎栓刀1270。其中，所述操作组件1000例如包括压柄1110以及传动部件1210，所述传动部件1210将所述压柄1110的作用力传递给所述齿轮组件1200。
重点参考图2所示，所述吸栓系统1包括连接部件1310、抽吸组件1320、排液管1370以及进液管1360，所述连接部件1310的一端与所述操作组件连接，跟随所述操作组件联动，所述连接部件1310的另一端与所述抽吸组件1320连接，所述连接部件1310带动所述抽吸组件1320形成压力腔，所述压力腔连接所述排液管1370及所述进液管1360，所述进液管1360与所述鞘管1340连接。
继续参考图2所示，所述排液管1370的一端与所述抽吸组件1320连通，所述排液管1370的另一端与收集容器1380连通，所述进液管1360的一端与所述抽吸组件1320连通，所述进液管1360的另一端与所述鞘管1340的一端 连接，所述鞘管1340的另一端与所述取栓头4连接。所述收集容器1380优选为收集袋或收集桶。
请参考图5，其为本实施例中取栓头4的局部剖面示意图。所述取栓头4通过固定环1333与所述鞘管1340连接，所述取栓头4具有顶孔1331和侧孔1332，所述顶孔1331用于溶栓药物的输送，所述侧孔1332用于抽吸血栓。为了便于碎栓，所述侧孔1332的位置与碎栓刀1270的位置相对应，使得通过侧孔1332吸入取栓头4内的血栓将直接被碎栓刀的碎栓刀刀锋1271粉碎。
为了满足抽吸组件的功能，如图3所示，所述抽吸组件1320包括：抽吸室1321、活塞1326及活塞杆1325，所述活塞1326套接于活塞杆1325的外侧，并内切于所述抽吸室1321，所述活塞杆1325远离活塞1326的一端与所述连接部件1310连接；操作组件受力时，所述压力腔为负压，操作组件不受力时，所述压力腔为正压。具体的，所述操作组件受力时(具体是所述压柄1110受到按压力时)，所述压柄1110依次带动连接部件1310、活塞杆1325、活塞1326向脱离所述抽吸室1321的方向运动，以使所述抽吸室1321内形成负压；所述压柄1110解除按压力时，在所述扭簧1120的作用下，所述压柄1110会自动恢复自然状态，从而依次带动连接部件1310、活塞杆1325、活塞1326向进入所述抽吸室1321的方向运动，以使所述抽吸室1321内形成正压。抽吸组件1320的结构包括但不局限于图3所示的结构，只要抽吸组件1320可以在压柄1110受到按压力的联动作用下，改变抽吸室1321的内部压强，从而在抽吸组件1320内形成负压，满足抽吸血栓的压强需求即可。
进一步地，抽吸组件1320工作时，每一时刻仅处于抽吸、排液中的一个状态，由于抽吸组件1320和排液管1370、进液管1360均连通，为了控制抽吸组件1320中液体的流向，所述抽吸组件1320还包括：第一单向阀1324及第二单向阀1324’，所述第一单向阀1324设置于所述进液管1360上，所述第二单向阀1324’设置于所述排液管1370上。所述抽吸组件1320内形成负压时，在负压的作用下，所述第一单向阀1324打开，所述第二单向阀1324’关闭，所述取栓头4吸入的血栓经所述鞘管1340、所述进液管1360被传输至所述抽吸室1321内(即抽吸组件1320处于抽吸状态)；所述抽吸组件1320内 形成正压时，在正压的作用下，所述第一单向阀1324关闭，所述第二单向阀1324’打开，已传输至所述抽吸室1321内的血栓通过所述排液管1370传输至收集容器1380内(即抽吸组件1320处于排液状态)。
优选的，所述第一单向阀1324和所述第二单向阀1324’均为伞阀；所述抽吸室1321为壳体结构且具有进液腔1322和排液腔1323，所述进液腔1322与所述进液管1360连通(所述进液管1360可采用胶水粘接方式粘接于所述进液腔1322外侧)，所述排液腔1323与所述排液管1370连通(所述排液管1370可采用胶水粘接方式粘接于所述排液腔1323外侧)，且所述进液腔1322和所述排液腔1323内均具有凸台，伞阀分别安装在对应的凸台上，且进液腔1322中的伞阀与排液腔1323中的伞阀是同向设置，因此，进液腔1322中的伞阀打开时排液腔1323中的伞阀会在内部压力作用下自动关闭，反之亦然。
本实施例中，所述连接部件1310的具体结构可以为两种，具体如下。
结构一：所述连接部件1310为一连接杆，所述连接杆的一端通过销轴与所述压柄1110连接，所述连接杆的另一端穿过所述抽吸室1321的体壁与所述活塞杆1325连接。当所述压柄1110受到按压力时，将通过所述连接杆带动活塞杆1325运动。
上述结构一具有结构简单的优点，但是可能存在的不足在于，由于连接杆为一杆状体，在压柄1110的作用力带动下，连接杆带动与其连接的活塞杆1325在水平方向和竖直方向均有位移，因此，活塞1326与抽吸室1321之间存在相对水平运动，不利于活塞1326在抽吸室1321中的密封效果，增大了对活塞1326和抽吸室1321的磨损。
结构二：请参考图3，所述连接部件1310为一U型结构，所述U型结构的底端连接杆与压柄1110连接，U型结构的开口端与所述抽吸组件1320连接(具体是穿过所述抽吸室1321的体壁并通过销轴1327与所述活塞杆1325连接)。结构二克服了结构一可能存在的问题，通过U型结构的开口端穿过所述抽吸室1321的体壁并通过销轴1327与所述活塞杆1325连接，从而使得活塞杆1325可以沿贯穿U型结构的开口端的销轴1327水平移动，而活塞1326不存在相对于抽吸室1321的水平位移，避免活塞1326与抽吸室1321体壁的摩 擦。该技术方案采用U型结构的好处是活塞杆在运动时不会受到扭力，它的受力方向始终在抽吸室的轴线上。
请继续参考图1，所述压柄1110包括壳体1130及通过销轴安装在壳体1130内的扭簧1120，所述压柄1110解除按压力时，在所述扭簧1120的作用下，所述压柄1110会自动恢复自然状态。
本实施例中，如图1所示，所述机械血栓去除装置还可包括一溶栓系统2。所述溶栓系统2包括注射器1410、输液管1430及第三单向阀1420，所述输液管1430与所述注射器1410连接，所述第三单向阀1420设置于所述输液管1430上，所述注射器1410将承载的溶栓药物通过输液管1430灌注到达血栓部位，对血栓部位的血栓进行软化或溶解。所述第三单向阀1420的设置目的是避免输液管1430中溶栓药物倒流，实现溶栓药物自注射器1410至输液管1430的单向流动。
进一步地，所述碎栓系统3还包括传动管尾端连接件1280以及设置于传动管尾端连接件1280上的可调止血阀(图4中未标示)。
参考图1和图4，所述传动部件1210的一端与所述压柄1110固定连接，所述传动部件1210的另一端与所述齿轮组件1200啮合，所述传动管1260的一端与所述传动管尾端连接件1280连接，所述传动管1260的另一端(远端)与所述碎栓刀1270固定连接，并容置于所述鞘管1340内；所述传动部件1210将所述压柄1110的作用力传递给所述齿轮组件1200，所述齿轮组件1200在所述压柄1110的作用力下把旋转运动传递给所述传动管1260，所述传动管1260带动所述碎栓刀1270旋转，对已吸入所述取栓头4的血栓进行碎栓。本实施例中，所述传动部件1210优选为齿条，更优选为弧形齿条。
如图8所示，所述齿轮组件1200包括第一锥齿轮1240及第二锥齿轮1250，所述第一锥齿轮1240与第二锥齿轮1250啮合，所述第二锥齿轮1250与所述传动管1260固定。进一步的，所述齿轮组件还包括第一齿轮1220、第二齿轮1230、棘轮1223和第三齿轮1241，所述传动部件1210与所述第一齿轮1220啮合，所述第一齿轮1220与所述第二齿轮1230共用所述棘轮1223，所述第二齿轮1230与所述第三齿轮1241啮合，所述第三齿轮1241与所述第 一锥齿轮1240共轴，所述第二锥齿轮1250与所述第一锥齿轮1240啮合。
请参考图4或图8，所述齿轮组件1200的工作过程如下：
压柄1110受到按压力时，与压柄1110固定连接的传动部件1210向图示的右下方运动，碎栓传动部件1210带动第一齿轮1220逆时针转动，所述第一齿轮1220带动所述第二齿轮1230逆时针转动，所述第二齿轮1230通过第三齿轮带动第一锥齿轮1240转动，第一锥齿轮1240带动第二锥齿轮1250转动，第二锥齿轮1250带动传动管1260转动，传动管1260带动碎栓刀1270转动。
压柄1110解除按压力时，与压柄1110固定连接的传动部件1210向图示的左上方运动，传动部件1210带动第一齿轮1220顺时针转动，在棘轮1223的作用下所述第二齿轮1230不会因所述第一齿轮1220的转动而转动，即第一齿轮1220的转动截止于棘轮1223处，第二齿轮1230、第一锥齿轮1240、第二锥齿轮1250和传动管1260均不转动。
如图1所示，所述碎栓系统4及所述吸栓系统1均通过所述鞘管连接件1350与所述鞘管1340连接，所述传动管1260穿过所述鞘管连接件1350并容置于所述鞘管1340中。
其中，所述鞘管连接件1350的一端与所述鞘管1340远离所述取栓头4的一端连接。通过鞘管连接件1350实现鞘管1340与吸栓系统1、溶栓系统2、碎栓系统3之间的连接。具体的，所述传动管1260包括：顺次连通的前端传动管1263、中间传动管1262及尾端传动管1261；其中，所述前端传动管1263和所述尾端传动管1261为单层或多层复合管材的中空管状构件；所述前端传动管1263和所述尾端传动管1261为多层复合管材时可包含金属编织层和内衬层；所述中间传动管1262上具有至少一个侧孔1262a(见图6)，进入所述鞘管连接件1350内的液体通过侧孔1262a进入所述中间传动管1262内；所述碎栓刀1270固定于所述前端传动管1263上并容置于所述鞘管1340内，所述中间传动管1262容置于所述鞘管连接件1350内，所述尾端传动管1261远离所述中间传动管1262的一端与传动管尾端连接件1280连接，所述第二锥齿轮1250套接于所述尾端传动管1261外(换言之，所述尾端传动管1261穿 过所述第二锥齿轮1250的中心孔并与所述第二锥齿轮1250固定连接，从而在所述第二锥齿轮1250转动时，尾端传动管1261会随之转动，进而带动固定于前端传动管1263上的碎栓刀1270转动，进行碎栓工作)。
为了实现鞘管1340分别与吸栓系统1、溶栓系统2、碎栓系统3的连接，如图6所示，将鞘管连接件1350设计为包括：总连接件1350a，与所述总连接件1350a的一端连通的第二分叉连接件1350c和第三分叉连接件1350d，以及与所述总连接件1350a的另一端连通的第一分叉连接件1350b，其中，所述总连接件1350a的另一端也与所述鞘管1340连通。在所述吸栓系统1中，所述进液管1360通过所述第一分叉连接件1350b与所述鞘管1340连接；所述碎栓系统3通过所述第二分叉连接件1350c与所述鞘管1340连接；在所述溶栓系统2中，所述输液管1430通过所述第三分叉连接件1350d与所述鞘管1340连通，通过输液管1430输送至鞘管1340中的液体(例如溶栓药物)可通过中间传动管1262上的侧孔1262a进入传动管中。
在制备本实施例中机械血栓去除装置的各个部件时，每个部件均可通过机加工、注塑、挤出和激光雕刻等加工方式制作；不同部件之间的固定连接可采用激光焊接或胶水粘接的方式，例如前端传动管1263、中间传动管1262和尾端传动管1261之间通过激光依次焊接组成传动管，碎栓刀1270通过激光焊接固定在前端传动管1263上。由于各部件的制备和组装方式不涉及本发明技术方案的重点，此处不作过多赘述。
为了较好的理解本发明的机械血栓去除装置，下面结合图1详细阐述机械血栓去除装置应用的过程，具体过程如下：
手术开始前，将取栓头4放置在生理盐水中，手动按压压柄1110至收集容器1380中可见生理盐水时，停止按压压柄1110，将注射器1410连接第三单向阀1420进行抽吸，当注射器1410中可见生理盐水时停止抽吸，排空机械血栓去除装置内的空气。手术开始前手动按压压柄1110时抽吸组件1320的作用原理与以下手术过程中手动按压压柄1110时相同。
手术过程中，穿刺血管，将机械血栓去除装置沿导丝(外购)到达血栓部位，具体为鞘管1340及取栓头4部分均进入患者体内，其余结构均处于患 者体外，取栓头4到达血栓部位。溶栓过程：将注射器1410抽吸溶栓药后与第三单向阀1420联通，按压注射器1410，将溶栓药物通过输液管1430和中间传动管1262上的侧孔1262a，依次灌注到中间传动管1262的内腔、前端传动管1263内腔，最后经过取栓头4的顶孔1331到达血栓部位，溶栓药物接触血栓后对其进行软化或溶解，完成溶栓过程。预定时间后，进行吸栓及碎栓，按压压柄1110，齿轮组件1200在压柄1110作用下把旋转运动传递给传动管，然后传动管带动碎栓刀1270旋转；同时，压柄1110通过连接部件1310、活塞杆1325带动活塞1326在抽吸室1321内进行抽吸和排液。压柄1110被手动按压下时，活塞1326从抽吸室1321向外运动，抽吸组件1320进行抽吸；放开压柄1110时，活塞1326向抽吸室1321内运动，抽吸组件1320进行排液。由于进液腔1322中的伞阀与排液腔1323中的伞阀是同向设置的，因此进液腔1322中的伞阀打开时排液腔1323中的伞阀会在内部压力作用下自动关闭，反之亦然。在抽吸时，进液腔1322中的伞阀打开，排液腔1323中的伞阀关闭，抽吸室1321、进液腔1322、进液管1360和鞘管1340形成的通路在负压的作用下把血栓通过取栓头4的侧孔1332吸入取栓头4内部，旋转的碎栓刀刀锋1271和取栓头4的侧孔1332配合将吸入内部的血栓切碎，同时，在负压作用下，切碎的血栓被吸入抽吸室1321内；在排液时，进液腔1322中的伞阀关闭，排液腔1323中的伞阀打开，抽吸室1321、排液腔1323、排液管1370形成的通路在正压作用下将切碎的血栓排出体外并输送至收集容器1380内。
取栓完毕后，停止按压压柄1110，将所有器件一同撤出人体。
实施例二
如图7所示，本实施例与实施例一区别之处在于，所述操作组件1000包括摇杆1140以及齿轮盘1231。其中，摇杆1140位于齿轮盘1231的一侧并通过轴连接，齿轮盘1231与第三齿轮1241啮合，第三齿轮1241与第一锥齿轮1240共轴，第一锥齿轮1240与第二锥齿轮1250啮合。
在制备本实施例中机械血栓去除装置的各个部件时，每个部件均可通过机加工、注塑、挤出和激光雕刻等加工方式制作。不同部件之间的固定连接 可采用激光焊接或胶水粘接的方式，例如，前端传动管1263、中间传动管1262和尾端传动管1261之间通过激光依次焊接组成传动管1260。
结合图2、图5和图6所示，中间传动管1262的近端焊接在尾端传动管1261上，中间传动管1262放置在鞘管连接件1350内，尾端传动管1261的一端穿过第二锥齿轮1250中孔并通过激光焊接相连，尾端传动管1261的另一端安装在传动管尾端连接件1280内。碎栓刀1270是通过激光焊接固定在前端传动管1263上并放置在鞘管1340内。
结合图3、图5至图7所示，本实施例中，连接杆1311铰接在齿轮盘1231的另一侧，滑块1312的一端与连接杆1311铰接，另一端与活塞杆1325通过销轴1327连接。第一单向阀1324、1324’分别安装在进液腔1322和排液腔1323内的凸台上，并保持同向。排液管1370的一端安装在排液腔1323外端并用胶水粘接，另一端安装在收集容器1380上。进液管1360的一端安装在进液腔1322外端并用胶水粘接，另一端安装在鞘管连接件1350的第一分叉连接件1350b上。取栓头4的近端与固定环1333的一端通过激光焊接。鞘管1340远端与固定环1333的另一端通过胶水粘接，鞘管1340近端与鞘管连接件1350通过胶水粘接。
重点参考图7所示，输液管1430的一端通过胶水粘接在鞘管连接件1350的第三分叉连接件1350d上，第三单向阀1420通过胶水粘接在输液管1430的另一端上，注射器1410固定在第三单向阀1420上，形成完整的机械血栓去除装置100。
为了较好的理解本实施例的机械血栓去除装置，下面结合图3、图5至图7详细阐述机械血栓去除装置应用的过程，具体过程如下：
手术开始前，将取栓头4放置在生理盐水中，逆时针转动摇杆1140至收集容器1380中可见生理盐水时，停止转动摇杆1140，将注射器1410连接单向阀1420进行抽吸，当注射器1410中可见生理盐水时停止抽吸，排空取栓装置内的空气。手术开始前转动摇杆1140时抽吸组件1320的作用原理与以下手术过程中转动摇杆1140时相同。
手术过程中，穿刺血管，将取栓装置沿导丝(外购)到达血栓部位，具 体为鞘管1340及取栓头4部分均进入患者体内，其余结构均处于患者体外，将注射器1410抽吸溶栓药后与单向阀1420联通，按压注射器1410，将溶栓药通过输液管1430和中间传动管侧孔1262a，依次灌注到中间传动管1262内腔，前端传动管1263内腔，最后经过顶孔1331到达血栓部位，溶栓药接触血栓后对其进行软化或溶解。预定时间后，逆时针转动摇杆1140，齿轮盘1231、第三齿轮1241、第一锥齿轮1240和第二锥齿轮1250组成的齿轮系统在摇杆1140作用下把旋转运动传递给传动管1260，然后传动管1260带动碎栓刀1270旋转；同时，摇杆1140通过齿轮盘1231、连接杆1311、滑块1312和活塞杆1325带动活塞1326在抽吸室1321内进行抽吸和排液。摇杆1140逆时针转动前半圈时，活塞1326从抽吸室1321向外运动，抽吸组件1320进行抽吸；摇杆1140逆时针转动后半圈时，活塞1326向抽吸室1321内运动，抽吸组件1320进行排液。由于进液腔1322的单向阀与排液腔1323的单向阀是同向设置的，因此进液腔1322的单向阀打开时排液腔1323的单向阀会在内部压力作用下自动关闭，反之亦然。在抽吸时，进液腔1322的单向阀打开，排液腔1323的单向阀关闭，抽吸室1331、进液腔1322、进液管1360和鞘管1340形成的通路在负压的作用下把血栓通过取栓头侧孔1332吸入取栓头4内部，旋转的碎栓刀刀锋1271和取栓头侧孔1332配合将吸入内部的血栓切碎，同时，在负压作用下，切碎的血栓被吸入抽吸室1331腔内；在排液时，进液腔1322的单向阀关闭，排液腔1323的单向阀打开，抽吸室1331、排液腔1323、排液管1370形成的通路在正压作用下将切碎的血栓排出体外并输送至收集容器1380内。
取栓完毕后，停止转动摇杆1140，将所有器件一同撤出人体。
综上，本发明的机械血栓去除装置具有以下有益效果：
(1)结合了碎栓、溶栓和吸栓，避免大块血栓堵塞管腔而影响取栓效率；
(2)由于吸栓和碎栓的动力来源均来自于操作者对压柄或摇杆的操作，因此吸栓过程呈现波动式抽吸，利用波动的负压把位置不佳的血栓有效的吸入管腔并取出体外，进一步提高血栓取出率；
(3)手动按压压柄或摇动摇杆能够感受到血管内的抽吸压力，根据这种 压力的变化即可直观的感知到是否抽吸到血栓，血栓的清除进程以及异常情况；
(4)装置操作简单，只需按压压柄或摇动摇杆即可实现取栓，医生可以把更多的精力投入到患者的治疗方面。
上述描述仅是对本发明较佳实施例的描述，并非对本发明范围的任何限定，本发明领域的普通技术人员根据上述揭示内容做的任何变更、修饰，均属于权利要求书的保护范围。

Claims (14)

  1. 一种血栓去除装置，其特征在于，包括:
    取栓头，具有供血栓进入所述取栓头的至少一个开孔，且所述取栓头连接鞘管；
    碎栓系统，包括操作组件、齿轮组件、传动管以及碎栓刀,所述操作组件通过齿轮组件带动传动管旋转，所述传动管的远端连接碎栓刀；
    吸栓系统，所述吸栓系统包括连接部件、抽吸组件、排液管以及进液管，所述连接部件的一端与所述操作组件连接，所述连接部件的另一端与所述抽吸组件连接，在所述操作组件的驱动下，所述连接部件带动所述抽吸组件形成压力腔，所述压力腔连接所述排液管及所述进液管，所述进液管与所述鞘管连接。
  2. 如权利要求1所述的血栓去除装置，其特征在于，所述操作组件包括压柄以及传动部件，所述传动部件将所述压柄的作用力传递给所述齿轮组件。
  3. 如权利要求2所述的血栓去除装置，其特征在于，所述压柄包括壳体及通过销轴安装于壳体内的扭簧，所述压柄解除按压力时，在所述扭簧的作用下，所述压柄会自动恢复自然状态。
  4. 如权利要求2所述的血栓去除装置，其特征在于，所述传动部件为弧形齿条。
  5. 如权利要求1所述的血栓去除装置，其特征在于，所述操作组件包括摇杆以及齿轮盘，所述齿轮盘与所述齿轮组件啮合。
  6. 如权利要求1所述的血栓去除装置，其特征在于，所述齿轮组件包括第一锥齿轮及第二锥齿轮，所述第一锥齿轮与第二锥齿轮啮合，所述第二锥齿轮与所述传动管固定。
  7. 如权利要求6所述的血栓去除装置，其特征在于，所述齿轮组件还包括第一齿轮、第二齿轮、棘轮和第三齿轮，所述操作组件与所述第一齿轮啮合，所述第一齿轮与所述第二齿轮共用所述棘轮，所述第二齿轮与所述第三齿轮啮合，所述第三齿轮与所述第一锥齿轮共轴。
  8. 如权利要求1所述的血栓去除装置，其特征在于，所述抽吸组件包括抽吸室、活塞及活塞杆，所述活塞套接于活塞杆的外侧，并内切于所述抽吸室，所述活塞杆远离活塞的一端与所述连接部件连接；所述操作组件受力时，所述压力腔内产生负压，所述操作组件不受力时，所述压力腔内产生正压。
  9. 如权利要求8所述的血栓去除装置，其特征在于，所述抽吸组件还包括：第一单向阀及第二单向阀，所述第一单向阀设置于所述进液管上，所述第二单向阀设置于所述排液管上。
  10. 如权利要求9所述的血栓去除装置，其特征在于，所述第一单向阀和所述第二单向阀的设置方向相同，使得所述第一单向阀和所述第二单向阀中的一个打开时，另一个关闭。
  11. 如权利要求1所述的血栓去除装置，其特征在于，所述连接部件为U型结构，所述U型结构的底端连接杆与所述操作组件连接，所述U型结构的开口端与所述抽吸组件连接。
  12. 如权利要求1所述的血栓去除装置，其特征在于，所述取栓头包括一鞘管连接件，所述碎栓系统及所述吸栓系统均通过所述鞘管连接件与所述鞘管连接，所述传动管穿过所述鞘管连接件并容置于所述鞘管中。
  13. 如权利要求1所述的血栓去除装置，其特征在于，所述碎栓系统还包括传动管尾端连接件以及设置于所述传动管尾端连接件上的可调止血阀。
  14. 如权利要求1所述的血栓去除装置，其特征在于，还包括溶栓系统，所述溶栓系统包括注射器、输液管及第三单向阀，所述输液管与所述注射器连接，所述第三单向阀设置于所述输液管上，所述注射器将承载的溶栓药物通过输液管灌注到达血栓部位，对血栓部位的血栓进行软化或溶解。
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CN114795391A (zh) * 2022-06-24 2022-07-29 北京华脉泰科医疗器械股份有限公司 双压栓状物提取装置及其控制方法
CN114795391B (zh) * 2022-06-24 2022-09-02 北京华脉泰科医疗器械股份有限公司 双压栓状物提取装置
CN117357208A (zh) * 2023-12-06 2024-01-09 乐普（北京）医疗器械股份有限公司 一种血管内血栓抽吸装置
CN117462210A (zh) * 2023-12-28 2024-01-30 北京大学第三医院（北京大学第三临床医学院） 一种血栓抽吸装置
CN117462210B (zh) * 2023-12-28 2024-04-16 北京大学第三医院（北京大学第三临床医学院） 一种血栓抽吸装置

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EP3662848B1 (en) 2023-07-05

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