WO2019004669A3 - 광감작제를 포함한 마이크로버블-나노입자 복합체 및 이를 포함하는 항암 치료제 - Google Patents

광감작제를 포함한 마이크로버블-나노입자 복합체 및 이를 포함하는 항암 치료제 Download PDF

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WO2019004669A3
WO2019004669A3 PCT/KR2018/007145 KR2018007145W WO2019004669A3 WO 2019004669 A3 WO2019004669 A3 WO 2019004669A3 KR 2018007145 W KR2018007145 W KR 2018007145W WO 2019004669 A3 WO2019004669 A3 WO 2019004669A3
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therapeutic agent
complex
microbubble
microbubbles
agent
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WO2019004669A2 (ko
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김현철
이호현
한현구
장혜진
김도연
유홍근
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서강대학교 산학협력단
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Publication of WO2019004669A3 publication Critical patent/WO2019004669A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 초음파 조영제, 광역학 치료제 및 화학적 약물 치료제로 동시에 사용가능하고, 초음파 감응을 통해 특정 암 조직에 선택적으로 약물과 광감작제를 전달할 수 있는 마이크로버블-나노입자 복합체 및 이를 포함하는 항암 치료제에 관한 것이다. 본 발명의 복합체는 마이크로 버블 내부에 초음파 조영제용 가스와 광감작제 물질을 함유하고, 마이크로 버블 표면에 결합된 나노입자는 약물을 함유하고 있으므로 초음파 조영제, 광역학 치료제 및 화학적 약물 치료제로 동시에 사용할 수 있다. 또한, 본 발명의 복합체는 초음파가 조사되면 마이크로 버블 코어 부분에 충진된 가스를 이용하여 병변 조직에 대한 초음파 영상을 제공할 수 있을 뿐만 아니라, 마이크로 버블을 좀 더 작은 크기의 미셀이나 리포좀으로 파괴하여 약물과 광감작제를 병변 조직에 효율적으로 침투 및 축적시킬 수 있다.
PCT/KR2018/007145 2017-06-26 2018-06-25 광감작제를 포함한 마이크로버블-나노입자 복합체 및 이를 포함하는 항암 치료제 WO2019004669A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170080296A KR102035384B1 (ko) 2017-06-26 2017-06-26 광감작제를 포함한 마이크로버블-나노입자 복합체 및 이를 포함하는 항암 치료제
KR10-2017-0080296 2017-06-26

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WO2019004669A2 WO2019004669A2 (ko) 2019-01-03
WO2019004669A3 true WO2019004669A3 (ko) 2019-02-14

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Families Citing this family (10)

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KR101950569B1 (ko) * 2017-03-10 2019-02-20 서강대학교산학협력단 기포의 체적 조절방법 및 기포의 체적 조절장치
GB201908352D0 (en) * 2019-06-11 2019-07-24 Innovation Ulster Ltd Sonodynamic therapy
KR102379296B1 (ko) * 2019-09-02 2022-03-29 (주)아이엠지티 면역 마이크로버블 복합체 및 이의 이용
KR102565700B1 (ko) * 2019-11-12 2023-08-17 서강대학교산학협력단 지질을 이용한 표면 개질을 통해 조직 투과성을 향상시킨 안약 제제용 나노입자 복합체
KR102398743B1 (ko) * 2020-09-03 2022-05-16 충남대학교병원 초음파유도 마이크로버블을 포함하는 배뇨장애 치료제 조성물
KR102578025B1 (ko) * 2020-12-07 2023-09-15 (주)아이엠지티 초음파 감작제가 결합된 면역관문억제제 및 이의 용도
CN114983942B (zh) * 2022-05-18 2023-09-05 中国科学院理化技术研究所 治疗幽门螺杆菌感染的多功能微泡、制备及其应用
KR102610361B1 (ko) * 2022-07-14 2023-12-06 (주) 바이오인프라생명과학 소수성 약물을 전달하기 위한 초음파 감응형 약물전달체를 생성하는 방법 및 이를 이용한 초음파 감응형 약물전달체
KR20240013509A (ko) * 2022-07-22 2024-01-30 (주)아이엠지티 초음파 감응형 포피린-리포좀 및 이의 용도
CN115154472B (zh) * 2022-07-27 2024-05-07 北京大学第三医院（北京大学第三临床医学院） 一种具有靶向功能的治疗脑卒中的氢化可的松多功能超声微泡

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WO2019004669A2 (ko) 2019-01-03
KR20190001022A (ko) 2019-01-04

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