WO2018226069A1 - Structure élastique de microaiguille - Google Patents

Structure élastique de microaiguille Download PDF

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Publication number
WO2018226069A1
WO2018226069A1 PCT/KR2018/006544 KR2018006544W WO2018226069A1 WO 2018226069 A1 WO2018226069 A1 WO 2018226069A1 KR 2018006544 W KR2018006544 W KR 2018006544W WO 2018226069 A1 WO2018226069 A1 WO 2018226069A1
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WO
WIPO (PCT)
Prior art keywords
microneedle
elastic
skin
elastic structure
rubber
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Application number
PCT/KR2018/006544
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English (en)
Korean (ko)
Inventor
이정규
Original Assignee
주식회사 스몰랩
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Publication date
Priority claimed from KR1020180045526A external-priority patent/KR101976431B1/ko
Application filed by 주식회사 스몰랩 filed Critical 주식회사 스몰랩
Publication of WO2018226069A1 publication Critical patent/WO2018226069A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles

Definitions

  • the present invention relates to a microneedle elastic structure comprising a microneedle portion in which a plurality of soluble microneedles are formed and an elastic portion coupled to the microneedle portion.
  • liquid agents, ointments, creams, tapes, patches, papes, and the like, which contain an active ingredient are known as agents for imparting at least one effect of modification and functional effects in the skin surface.
  • These agents are used by methods such as applying or applying to the skin. For this reason, there existed a fault, such as a loss or fall-off by sweating, washing
  • these preparations exert their first medicinal effects by infiltrating the skin with the active ingredient in the preparation and diffusing into the body.
  • the skin surface layer has a barrier function to prevent foreign substances from entering the body, it is difficult to absorb a sufficient amount of the active ingredient to exert a pharmacological effect, and it is difficult to reliably supply an active ingredient to a specific part of the skin surface layer. It is difficult.
  • an object of the present invention is to provide a microneedle elastic structure for delivering the active ingredient deep into the skin through the skin surface layer.
  • an object of the present invention is to provide a microneedle elastic structure capable of inserting the active ingredient evenly throughout the skin of the curved face.
  • an object of the present invention is to provide a microneedle elastic structure that can deliver the active ingredient further deep into the skin by applying pressure to the elastic portion.
  • an object of the present invention is to provide a microneedle elastic structure that can be easily transferred to the skin by dissolving the microneedle by an aqueous solution containing water or an active ingredient applied to the skin.
  • the microneedle elastic structure of the present invention may include a microneedle portion in which a plurality of soluble microneedles are formed and an elastic portion coupled to the microneedle portion.
  • the soluble microneedle may be dissolved by an aqueous solution containing water or an active ingredient applied to the skin.
  • the microneedle portion may contain an active ingredient.
  • the microneedle portion may be composed of a porous base portion and a plurality of soluble microneedles formed on the porous base portion.
  • the soluble microneedle may be any one or a mixture of two or more selected from an acrylic polymer, a vinyl alcohol polymer, a vinylpyrrolidone polymer, a cellulose derivative, an alkylene oxide polymer and a polysaccharide. .
  • the elastic part is butadiene rubber, styrene-butadiene rubber, styrene-butadiene-styrene rubber, acrylonitrile rubber, acrylonitrile-butadiene rubber, acrylic rubber, ethylene-propylene-diene rubber, ethylene-propylene It may include any one or a mixture of two or more selected from the group consisting of rubber, styrene-propylene rubber, silicone rubber, polyurethane rubber and hybrid silicone rubber.
  • the elastic portion may have a compressive permanent shrinkage measured in accordance with ASTM D395 of 0.1 to 70%.
  • the present invention may further include an adhesive layer for bonding the microneedle portion and the elastic portion.
  • According to an aspect of the present invention may further include a water supply portion between the microneedle portion and the elastic portion.
  • the moisture inside the water supply part may leak and the active ingredient in the dissolved microneedles may be absorbed or impregnated into the skin.
  • microneedle elastic structure according to the present invention has an advantage that the active ingredient can be delivered to the dermis layer deep through the skin surface layer.
  • microneedle elastic structure according to the present invention has the advantage that it is possible to deliver the active ingredient evenly throughout the skin without the gap of the curved face.
  • microneedle elastic structure according to the present invention has the advantage that can be applied to the entire skin when pressure is applied to the elastic portion can be delivered to the active ingredient deeper into the skin with excellent skin adhesion.
  • microneedle elastic structure according to the present invention has the advantage that the microneedle can be easily dissolved and delivered to the skin by an aqueous solution containing water or an active ingredient applied to the skin.
  • microneedle elastic structure according to the present invention has the advantage of minimizing skin damage, irritation and foreign body with excellent elastic recovery power, and can have an excellent touch.
  • FIG. 1 illustrates a microneedle elastic structure according to an embodiment of the present invention.
  • FIG. 2 illustrates a microneedle elastic structure according to another embodiment of the present invention.
  • Figure 3 shows a microneedle elastic structure according to another embodiment of the present invention.
  • Figure 4 illustrates a microneedle elastic structure according to another embodiment of the present invention.
  • FIG. 5 illustrates a microneedle elastic structure according to another embodiment of the present invention.
  • FIG. 6 illustrates a microneedle elastic structure according to another embodiment of the present invention.
  • FIG. 7 illustrates a microneedle elastic structure according to another embodiment of the present invention.
  • FIG. 8 illustrates a puff-type microneedle elastic structure according to an embodiment of the present invention.
  • FIG 9 illustrates a bone microneedle elastic structure according to an embodiment of the present invention.
  • Figure 10 illustrates a roller-type microneedle elastic structure according to an embodiment of the present invention.
  • microneedle 2 elastic part
  • the present invention relates to a microneedle elastic structure that can apply pressure evenly to the entire curved face and can deliver the active ingredient deep into the skin.
  • the microneedle elastic structure of the present invention may include a microneedle portion in which a plurality of soluble microneedles are formed and an elastic portion coupled to the microneedle portion.
  • the microneedle structures are hard plastic flat microneedle structures, and it is difficult to apply uniform pressure to the curved face as a whole, and it is difficult to uniformly transmit effective ingredients throughout the face.
  • an effective ingredient can be uniformly delivered to curved skin, especially a face, and a microneedle elastic structure can be delivered to the active ingredient deeply through the skin by easy pressure transfer.
  • the microneedle portion bonded to the elastic portion is composed of soluble so that the microneedle is inserted into the skin and dissolved by water or an aqueous solution containing the active ingredient applied to the skin is inserted into the active ingredient contained in the microneedle portion Can be released into the skin and delivered easily into the skin.
  • the soluble microneedle may be dissolved by an aqueous solution containing water or an active ingredient applied to the skin.
  • the soluble microneedles may be prepared by including a soluble polymer, specifically, may be a water-soluble polymer that can be dissolved in water, and is not irritated to the skin when applied to the skin. It may be a harmless polymer. Preferably, it may be any one or a mixture of two or more selected from an acrylic polymer, a vinyl alcohol polymer, a vinylpyrrolidone polymer, a cellulose derivative, an alkylene oxide polymer and a polysaccharide.
  • the acrylic polymer may be selected from polyacrylamide, polymethacrylate, polyethylacrylate, polyacrylate, sodium polyacrylate, acrylic acid-methacrylic acid copolymer, and the like.
  • the vinyl alcohol polymer may be selected from polyvinyl alcohol, polyvinylacetate, and polyvinylacetate-polyvinyl alcohol copolymer.
  • the cellulose derivative may be selected from cellulose, methyl cellulose, ethyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, cellulose acetate and cellulose acetate propionate.
  • the vinylpyrrolidone polymer may be selected from copolymers comprising polyvinylpyrrolidone and vinylpyrrolidone.
  • the alkylene oxide polymer may be selected from polyethylene oxide, polyethylene propylene glycol, polyethylene glycol diacrylate, polyethylene glycol dimethyl ether and polypropylene oxide.
  • the polysaccharide may be any one or a mixture of two or more selected from alginate, starch, xanthan gum, gellan gum, gelatin, chitosan, hyaluronic acid, dextran, xylose, sucrose, maltose, lactose, trehalose and chitosan. It is not limited to this.
  • the soluble polymer may have a weight average molecular weight of 1,000 to 3,000,000 g / mol, preferably a weight average molecular weight of 5,000 to 2,000,000 g / mol, but is not limited thereto.
  • an aqueous solution in which the soluble polymer is dispersed homogeneously and easily dissolved in water is provided, thus making it easy to manufacture in the shape of a microneedle, and the active ingredient may be uniformly dispersed in the microneedle.
  • the microneedle portion may contain an active ingredient. All active ingredients applied to the skin are difficult to be inserted into the skin and delivered.
  • the microneedle elastic structure according to an embodiment of the present invention contains an active ingredient in the microneedle, so that the active ingredient in the microneedle is eluted after the microneedle is inserted into the skin, so that the active ingredient can be delivered deep into the skin.
  • the microneedle may contain the active ingredient itself, but the microparticles, microcapsules, charge complex particles, and the active ingredient may be contained. It may also comprise one or more carriers selected from lipid complex particles and the like.
  • the carrier contains the active ingredient, and therefore, the carrier is present in the soluble polymer, so that partial diffusion and loss of the active ingredient can be prevented.
  • the carrier is delivered to the active ingredient deep into the skin can be expressed the effect of the active ingredient can be effectively expressed cosmetic effects on the skin.
  • microparticles are particles having a size of 1 mm or less, particles having a homogeneous spherical matrix, and may be, for example, spherical particles having a homogeneous density of soluble polymer, but are not limited thereto. .
  • the thin microcapsule means a spherical microcapsule containing a core surrounded by an active ingredient.
  • the microcapsules may be a shape containing an active ingredient in a core and a soluble polymer in a shell form, but not limited thereto. It doesn't happen.
  • the charge composite particles are complexes formed by physically bonding molecules having different charges.
  • composite particles in which anionic polymers and cationic polymers are physically bonded through different charges anion-charged polyethylene
  • anion-charged polyethylene Water dispersible composite particles through charge bonding between glycol and cation charged chitosan, water dispersible composite particles through charge bonding between anion-charged polyethylene glycol and cation-charged protein, polyethyleneimine charged with cation and anion
  • It may be any one or two or more charge complexes selected from water dispersible complex particles through charge bonding with charged proteins and water dispersible complex particles through charge bonding between cations-charged polyethylenimine and anionic alginate. Limited to this It is not.
  • the lipid complex particles are complexes formed by physical or chemical bonds between lipid-based molecules and non-lipidic molecules, and include, but are not limited to, complexes formed by physically mixing DOLE (dioleolphosphatidyl ethanolamine) with hyaluronic acid or chemically through amide bonds. Any one or two or more lipid complexes selected from a complex formed by bonding to a complex, a complex formed by chemically bonding a ceramide and a water-soluble protein through an ester bond, and a complex formed by chemically bonding a dotap and a water-soluble protein to each other through an amide bond. May be, but is not limited thereto.
  • DOLE dioleolphosphatidyl ethanolamine
  • the active ingredient may be contained in the soluble polymer by being trapped or supported in various forms such as a core-shell type, a multi-shell type, and a porous type, for example.
  • the carrier may have various shapes such as a sphere or a polygon, but is not limited thereto.
  • the average size of the carrier may be 0.01 to 300 ⁇ m. Preferably it may be 0.1 to 100 ⁇ m, but is not limited thereto. If it has an average size of the above range is preferable because it can contain a sufficient effective ingredient.
  • the active ingredient may be, for example, an antiwrinkle agent, a slimming agent, a whitening agent, an antiacne agent, a moisturizer, or an anti-boring agent. It may include any one or two or more selected from (antiseborrhoeicagent), anti-aging agent (antiaging agent), keratolytic agent, antibacterial gent and antifungal gent.
  • the active ingredient may include a functional cosmetics notified raw material or an unnotified raw material compound.
  • the functional cosmetics notification raw materials are retinol, retinyl palmitate, adenosine, polyethoxylatedrite dretin amide, young mulberry extract, arbutin, echyl ascorbyl ether, oil-soluble licorice extract, ascorbyl glucoside, magnesium ascorbyl phosphate , Niacinamide, alpha-bisabolol, ascorbyl triisopalmitate and the like.
  • the notice material is ginseng extract, red ginseng extract, wild ginseng culture extract or fermented product, roe deer extract, rice bran or its extract, brown rice or its extract, green tea extract, Compound K, catechin, Icariside B2, It may be any one or two or more selected from Icarside B6 and isoflavones.
  • the active ingredient may be any one or a mixture thereof selected from organic germanium, alkylene glycols, glycerin, vitamins, plant extracts and derivatives thereof, but is not limited thereto.
  • the microneedle of the present invention may further include ingredients listed in the list of cosmetic raw materials and ICID (International Cosmetic Raw Materials Collection) registered in the Food and Drug Administration as being included in a common cosmetic composition.
  • the component may be uniformly distributed throughout the nonwoven sheet or the elastic body, and specifically, may further include any one or a mixture of two or more selected from a thickener, a pH adjuster, an emulsifier, a pigment, a perfume, and the like, but is not limited thereto. It is not.
  • carbomer As the thickener, carbomer, acrylate, ammonium acryloyldimethyl taurate-vinylpyrrolidone copolymer, acrylate-C 10 -C 30 alkyl acrylate crosspolymer, xanthan gum and cellulose gum can be used.
  • any one or two selected from powders of known minerals or grains for example, ocher, bentonite, tourmaline, ganbanite, calcium carbonate, rice bran, barley, wheat, buckwheat, brown rice, soybean, red beans, mung beans and corn powder The above mixture may be used, but is not limited thereto.
  • the pH regulator examples include organic acids such as citric acid, succinic acid, tartaric acid, lactic acid, malic acid, fumaric acid, maleic acid and glycolic acid; inorganic acids such as hydrochloric acid, sulfuric acid, phosphoric acid and nitric acid; sodium, potassium or ammonium salts of these acids, And it may be used any one or two or more selected from arginine and the like. In addition, one or a mixture of two or more selected from triethanolamine, sodium chloride, sodium hydroxide and potassium hydroxide may be used, but is not limited thereto.
  • the emulsifier is not limited as long as it is a raw material generally used in the art, but may be selected from cationic surfactants, anionic surfactants, amphoteric surfactants and nonionic surfactants, but is not limited thereto.
  • the pigments and fragrances can be used components commonly used in cosmetic compositions, but is not limited thereto.
  • the microneedle portion may be composed of a porous base portion and a plurality of soluble microneedles formed on the porous base portion.
  • the pressure applied to the microneedle through the elastic part may be uniformly dispersed in the microneedle.
  • the porous base portion supports the substrate, and the porous base portion may be provided with mechanical strength to the microneedle portion, and may have a rigid or flexible structure. If desired, another second substrate may be further provided.
  • the porous base may further have a through hole, through which the additional active ingredient may be delivered from the opposite side of the microneedle toward the skin.
  • the porous base portion may be a planar body having a predetermined thickness, and may be a resin film, a resin sheet, a fiber sheet of a woven or nonwoven structure.
  • the resin can be made of the same soluble polymer as the microneedle or of a different polymer.
  • any one selected from polyolefins, polyesters, polyamides, polyurethanes, polyimides, polyvinyl chlorides, and the like, or copolymers thereof may be included.
  • More specific examples include any one or two selected from polyethylene, polypropylene, polyvinyl chloride, polyethylene terephthalate (PET), polybutylene terephthalate (PBT), polyamide, polyurethane, polyimide, polyvinyl chloride, and the like. It may contain a mixture of the above.
  • the fiber sheet may also be made of the resin described above.
  • the porous base is not particularly limited, it is suitable for the purpose of the present invention to have a porosity of 1,000 to 20,000 g / m 2 ⁇ 24hr, more preferably of 6,000 to 15,000 g / m 2 ⁇ 24hr.
  • the porous base is not particularly limited, but may have pores having an average pore size of 0.01 to 500 ⁇ m, preferably 1 to 300 ⁇ m, so as to facilitate water supply or passage of the active ingredient. However, it is not limited thereto.
  • the height of the soluble microneedle may be 50 to 1,500 ⁇ m, and the thickness of the porous base of the microneedle may be 10 to 1,000 ⁇ m.
  • the soluble microneedle height may be 50 to 1,000 ⁇ m, and the thickness of the porous base of the microneedle may be 10 to 500 ⁇ m.
  • the elastic portion may be coupled to the microneedle portion.
  • the microneedle elastic structure coupled as described above is deformed to conform to the curved face, so that the pressure is transmitted to the entire face, and thus the effective ingredient can be delivered uniformly. There is an advantage that can be delivered to the active ingredient deep.
  • the elastic portion may be composed of an elastic body or an elastomer according to one aspect.
  • the elastomer or elastomer may mean a natural material itself having elastomeric properties, and may include a foam having elastomeric properties.
  • elastomer or elastomer examples include butadiene rubber, styrene-butadiene rubber, styrene-butadiene-styrene rubber, acrylonitrile rubber, acrylonitrile-butadiene rubber, acrylic rubber, ethylene-propylene-diene rubber, ethylene-propylene rubber It may include any one or a mixture of two or more selected from the group consisting of styrene-propylene rubber, silicone rubber, polyurethane rubber and hybrid silicone rubber.
  • the use of the elastomer or the elastomer of the present invention is a configuration that can solve the difficulty of transmitting the active ingredient to the deep skin is weak due to the force delivered to the pressure applied to the face is weak. Due to this, the microneedle elastic structure of the present invention is deformed to fit the curved face as it is combined with the elastic portion and the microneedle portion including the elastic body or the elastomer, so that pressure transmission is uniform throughout the face, thereby effectively delivering the active ingredient. By applying strong pressure on the hand, pressure can be easily delivered to the face, and active ingredients can be delivered deep into the skin.
  • the elastic body or elastomer has a compressive permanent shrinkage after compression measured at 70 ° C. for 168 hours based on ASTM D395, at 0.1 to 70%.
  • the compressive permanent shrinkage may be 0.1 to 50%.
  • the pressure is inserted into the skin and the elastic part immediately recovers after penetrating the microneedle, thereby shortening the time for the microneedles to stay in the skin, minimizing damage, irritation and foreign matter on the skin, thereby providing a very good touch.
  • the elastomer or elastomer may have a Shore Hardness 00 (shore 00) of 20 to 98 measured according to ASTM D2240. Preferably from 25 to 80, more preferably from 30 to 70.
  • Shore hardness 00 shore 00
  • the shape of the elastic part there is no limitation on the shape of the elastic part, and for example, the shape of the elastic part may be combined with the microneedle part without being limited in shape in addition to the spherical shape, the polygon, the rectangular parallelepiped, and the like.
  • the adhesive layer is urea, melamine, phenol, unsaturated polyester, epoxy, resorcinol, vinyl acetate, polyvinyl alcohol, vinyl chloride, saturated polyester, polyvinyl acetal, acrylic, poly Any one selected from the group consisting of amide, polyethylene, butadiene rubber, nitrile rubber, butyl rubber, silicone rubber, chloroprene rubber, vinyl, phenol-chloroprene, epoxidized nitrile rubber, glue, latex, rosin and shellac It may consist of one or more adhesives.
  • the adhesive of the present invention may be formed by applying an adhesive to a surface to which the microneedle portion and the elastic portion are coupled. It may be coated or partially applied. Preferably it can be applied by viscous coating. It is more economical than being applied to the front surface, and porosity and moisture permeability can be secured by front bonding.
  • the moisture supply part may form an empty space by adjusting the shape of the elastic part between the microneedle part and the elastic part, and position the water supply part in the empty space.
  • the water supply unit may be composed of an aqueous solution containing water or an active ingredient. Specifically, when the pressure is applied to the elastic part, the moisture inside the water supply part may leak and the active ingredient in the dissolved microneedles may be absorbed or impregnated into the skin.
  • the active ingredient can be delivered into the skin, which is more preferable.
  • microneedle elastic structure according to the present invention will be described in more detail with reference to the following examples.
  • the following examples are only one reference for describing the present invention in detail, and the present invention is not limited thereto and may be implemented in various forms.
  • the microneedle elastic structure when the microneedle elastic structure includes soluble microneedles, the soluble microneedles inserted into the skin by an aqueous solution containing water or an active ingredient applied to the skin or a water supply part inside the elastic structure. Dissolved and the effective ingredient is delivered to the dermis can express more excellent cosmetic effect.
  • the pressure applied to the elastic portion can be uniformly delivered to the microneedle portion, and the active ingredient can be delivered deeply to the skin, and the elastic structure is variably deformed even when used on the curved face by the elastic portion. As a result, the active ingredient may be uniformly delivered to the entire curved face.
  • the microneedle elastic structure is made of an elastic part comprising an elastic body or elastomer satisfying the compressive permanent shrinkage of 0.1 to 70% after compression for 168 hours at 70 °C based on ASTM D395
  • it has an excellent elastic recovery rate capable of transmitting sufficient force to penetrate the microneedle into the skin, and the active ingredient can be delivered deep into the skin.
  • the microelastic penetrates into the skin and thus returns to the skin without staying in the skin for a long time with excellent elastic recovery, thereby preventing damage and irritation to the skin and providing excellent touch with a little foreign body.
  • the active ingredient in the form of microcapsules in the microneedle when delivering the active ingredient in the form of microcapsules in the microneedle can be delivered in the skin without loss, the active ingredient provided in the skin is released slowly in the skin can be improved in the persistence of the effective ingredient effect.
  • the pressure of the elastic portion is transferred to dissolve the microneedles inserted into the skin more easily, and the moisture is transferred as the pressure of the elastic portion is directly transmitted.
  • the calendar is further improved and desirable.
  • porous base portion when the porous base portion is formed in the microneedle portion, it is better for skin insertion of the soluble microneedle with better pressure transfer.
  • the microneedle elastic structure of the present invention can provide an effective ingredient uniformly to curved skin, in particular, the face, and can provide a microneedle elastic structure that can easily deliver pressure to the active ingredient deep into the skin.
  • the microneedle portion bonded to the elastic portion is soluble, the microneedle is inserted into the skin and then dissolved by an aqueous solution containing water or an active ingredient applied to the skin to release the active ingredient contained in the microneedle portion. It can be easily delivered deep into the skin.
  • the microneedle elastic structure according to the present invention may exhibit a uniform and high cosmetic effect expression rate over the entire face, and thus may achieve an excellent effect even if it includes any active ingredient that can obtain a cosmetic effect.
  • the skin has excellent touch to less skin irritation and foreign body feeling, it showed an excellent preference in sensory evaluation.

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Abstract

La présente invention concerne une structure élastique de microaiguille comprenant une partie microaiguille dans laquelle une pluralité de microaiguilles solubles est formée, et une partie élastique accouplée à la partie microaiguille.
PCT/KR2018/006544 2017-06-09 2018-06-08 Structure élastique de microaiguille WO2018226069A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20170072332 2017-06-09
KR10-2017-0072332 2017-06-09
KR1020180045526A KR101976431B1 (ko) 2017-06-09 2018-04-19 마이크로니들 탄성구조체
KR10-2018-0045526 2018-04-19

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KR101549086B1 (ko) * 2014-11-10 2015-09-02 주식회사 스몰랩 마이크로 니들 및 마이크로 니들 패치
KR101703050B1 (ko) * 2014-07-10 2017-02-07 주식회사 주빅 경피전달용 미세돌기 구조체
KR20170040767A (ko) * 2015-10-05 2017-04-13 주식회사 엘지생활건강 용해성 마이크로니들 마스크 키트

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