WO2018226069A1 - Micro needle elastic structure - Google Patents

Micro needle elastic structure Download PDF

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Publication number
WO2018226069A1
WO2018226069A1 PCT/KR2018/006544 KR2018006544W WO2018226069A1 WO 2018226069 A1 WO2018226069 A1 WO 2018226069A1 KR 2018006544 W KR2018006544 W KR 2018006544W WO 2018226069 A1 WO2018226069 A1 WO 2018226069A1
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WO
WIPO (PCT)
Prior art keywords
microneedle
elastic
skin
elastic structure
rubber
Prior art date
Application number
PCT/KR2018/006544
Other languages
French (fr)
Korean (ko)
Inventor
이정규
Original Assignee
주식회사 스몰랩
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020180045526A external-priority patent/KR101976431B1/en
Application filed by 주식회사 스몰랩 filed Critical 주식회사 스몰랩
Publication of WO2018226069A1 publication Critical patent/WO2018226069A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles

Definitions

  • the present invention relates to a microneedle elastic structure comprising a microneedle portion in which a plurality of soluble microneedles are formed and an elastic portion coupled to the microneedle portion.
  • liquid agents, ointments, creams, tapes, patches, papes, and the like, which contain an active ingredient are known as agents for imparting at least one effect of modification and functional effects in the skin surface.
  • These agents are used by methods such as applying or applying to the skin. For this reason, there existed a fault, such as a loss or fall-off by sweating, washing
  • these preparations exert their first medicinal effects by infiltrating the skin with the active ingredient in the preparation and diffusing into the body.
  • the skin surface layer has a barrier function to prevent foreign substances from entering the body, it is difficult to absorb a sufficient amount of the active ingredient to exert a pharmacological effect, and it is difficult to reliably supply an active ingredient to a specific part of the skin surface layer. It is difficult.
  • an object of the present invention is to provide a microneedle elastic structure for delivering the active ingredient deep into the skin through the skin surface layer.
  • an object of the present invention is to provide a microneedle elastic structure capable of inserting the active ingredient evenly throughout the skin of the curved face.
  • an object of the present invention is to provide a microneedle elastic structure that can deliver the active ingredient further deep into the skin by applying pressure to the elastic portion.
  • an object of the present invention is to provide a microneedle elastic structure that can be easily transferred to the skin by dissolving the microneedle by an aqueous solution containing water or an active ingredient applied to the skin.
  • the microneedle elastic structure of the present invention may include a microneedle portion in which a plurality of soluble microneedles are formed and an elastic portion coupled to the microneedle portion.
  • the soluble microneedle may be dissolved by an aqueous solution containing water or an active ingredient applied to the skin.
  • the microneedle portion may contain an active ingredient.
  • the microneedle portion may be composed of a porous base portion and a plurality of soluble microneedles formed on the porous base portion.
  • the soluble microneedle may be any one or a mixture of two or more selected from an acrylic polymer, a vinyl alcohol polymer, a vinylpyrrolidone polymer, a cellulose derivative, an alkylene oxide polymer and a polysaccharide. .
  • the elastic part is butadiene rubber, styrene-butadiene rubber, styrene-butadiene-styrene rubber, acrylonitrile rubber, acrylonitrile-butadiene rubber, acrylic rubber, ethylene-propylene-diene rubber, ethylene-propylene It may include any one or a mixture of two or more selected from the group consisting of rubber, styrene-propylene rubber, silicone rubber, polyurethane rubber and hybrid silicone rubber.
  • the elastic portion may have a compressive permanent shrinkage measured in accordance with ASTM D395 of 0.1 to 70%.
  • the present invention may further include an adhesive layer for bonding the microneedle portion and the elastic portion.
  • According to an aspect of the present invention may further include a water supply portion between the microneedle portion and the elastic portion.
  • the moisture inside the water supply part may leak and the active ingredient in the dissolved microneedles may be absorbed or impregnated into the skin.
  • microneedle elastic structure according to the present invention has an advantage that the active ingredient can be delivered to the dermis layer deep through the skin surface layer.
  • microneedle elastic structure according to the present invention has the advantage that it is possible to deliver the active ingredient evenly throughout the skin without the gap of the curved face.
  • microneedle elastic structure according to the present invention has the advantage that can be applied to the entire skin when pressure is applied to the elastic portion can be delivered to the active ingredient deeper into the skin with excellent skin adhesion.
  • microneedle elastic structure according to the present invention has the advantage that the microneedle can be easily dissolved and delivered to the skin by an aqueous solution containing water or an active ingredient applied to the skin.
  • microneedle elastic structure according to the present invention has the advantage of minimizing skin damage, irritation and foreign body with excellent elastic recovery power, and can have an excellent touch.
  • FIG. 1 illustrates a microneedle elastic structure according to an embodiment of the present invention.
  • FIG. 2 illustrates a microneedle elastic structure according to another embodiment of the present invention.
  • Figure 3 shows a microneedle elastic structure according to another embodiment of the present invention.
  • Figure 4 illustrates a microneedle elastic structure according to another embodiment of the present invention.
  • FIG. 5 illustrates a microneedle elastic structure according to another embodiment of the present invention.
  • FIG. 6 illustrates a microneedle elastic structure according to another embodiment of the present invention.
  • FIG. 7 illustrates a microneedle elastic structure according to another embodiment of the present invention.
  • FIG. 8 illustrates a puff-type microneedle elastic structure according to an embodiment of the present invention.
  • FIG 9 illustrates a bone microneedle elastic structure according to an embodiment of the present invention.
  • Figure 10 illustrates a roller-type microneedle elastic structure according to an embodiment of the present invention.
  • microneedle 2 elastic part
  • the present invention relates to a microneedle elastic structure that can apply pressure evenly to the entire curved face and can deliver the active ingredient deep into the skin.
  • the microneedle elastic structure of the present invention may include a microneedle portion in which a plurality of soluble microneedles are formed and an elastic portion coupled to the microneedle portion.
  • the microneedle structures are hard plastic flat microneedle structures, and it is difficult to apply uniform pressure to the curved face as a whole, and it is difficult to uniformly transmit effective ingredients throughout the face.
  • an effective ingredient can be uniformly delivered to curved skin, especially a face, and a microneedle elastic structure can be delivered to the active ingredient deeply through the skin by easy pressure transfer.
  • the microneedle portion bonded to the elastic portion is composed of soluble so that the microneedle is inserted into the skin and dissolved by water or an aqueous solution containing the active ingredient applied to the skin is inserted into the active ingredient contained in the microneedle portion Can be released into the skin and delivered easily into the skin.
  • the soluble microneedle may be dissolved by an aqueous solution containing water or an active ingredient applied to the skin.
  • the soluble microneedles may be prepared by including a soluble polymer, specifically, may be a water-soluble polymer that can be dissolved in water, and is not irritated to the skin when applied to the skin. It may be a harmless polymer. Preferably, it may be any one or a mixture of two or more selected from an acrylic polymer, a vinyl alcohol polymer, a vinylpyrrolidone polymer, a cellulose derivative, an alkylene oxide polymer and a polysaccharide.
  • the acrylic polymer may be selected from polyacrylamide, polymethacrylate, polyethylacrylate, polyacrylate, sodium polyacrylate, acrylic acid-methacrylic acid copolymer, and the like.
  • the vinyl alcohol polymer may be selected from polyvinyl alcohol, polyvinylacetate, and polyvinylacetate-polyvinyl alcohol copolymer.
  • the cellulose derivative may be selected from cellulose, methyl cellulose, ethyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, cellulose acetate and cellulose acetate propionate.
  • the vinylpyrrolidone polymer may be selected from copolymers comprising polyvinylpyrrolidone and vinylpyrrolidone.
  • the alkylene oxide polymer may be selected from polyethylene oxide, polyethylene propylene glycol, polyethylene glycol diacrylate, polyethylene glycol dimethyl ether and polypropylene oxide.
  • the polysaccharide may be any one or a mixture of two or more selected from alginate, starch, xanthan gum, gellan gum, gelatin, chitosan, hyaluronic acid, dextran, xylose, sucrose, maltose, lactose, trehalose and chitosan. It is not limited to this.
  • the soluble polymer may have a weight average molecular weight of 1,000 to 3,000,000 g / mol, preferably a weight average molecular weight of 5,000 to 2,000,000 g / mol, but is not limited thereto.
  • an aqueous solution in which the soluble polymer is dispersed homogeneously and easily dissolved in water is provided, thus making it easy to manufacture in the shape of a microneedle, and the active ingredient may be uniformly dispersed in the microneedle.
  • the microneedle portion may contain an active ingredient. All active ingredients applied to the skin are difficult to be inserted into the skin and delivered.
  • the microneedle elastic structure according to an embodiment of the present invention contains an active ingredient in the microneedle, so that the active ingredient in the microneedle is eluted after the microneedle is inserted into the skin, so that the active ingredient can be delivered deep into the skin.
  • the microneedle may contain the active ingredient itself, but the microparticles, microcapsules, charge complex particles, and the active ingredient may be contained. It may also comprise one or more carriers selected from lipid complex particles and the like.
  • the carrier contains the active ingredient, and therefore, the carrier is present in the soluble polymer, so that partial diffusion and loss of the active ingredient can be prevented.
  • the carrier is delivered to the active ingredient deep into the skin can be expressed the effect of the active ingredient can be effectively expressed cosmetic effects on the skin.
  • microparticles are particles having a size of 1 mm or less, particles having a homogeneous spherical matrix, and may be, for example, spherical particles having a homogeneous density of soluble polymer, but are not limited thereto. .
  • the thin microcapsule means a spherical microcapsule containing a core surrounded by an active ingredient.
  • the microcapsules may be a shape containing an active ingredient in a core and a soluble polymer in a shell form, but not limited thereto. It doesn't happen.
  • the charge composite particles are complexes formed by physically bonding molecules having different charges.
  • composite particles in which anionic polymers and cationic polymers are physically bonded through different charges anion-charged polyethylene
  • anion-charged polyethylene Water dispersible composite particles through charge bonding between glycol and cation charged chitosan, water dispersible composite particles through charge bonding between anion-charged polyethylene glycol and cation-charged protein, polyethyleneimine charged with cation and anion
  • It may be any one or two or more charge complexes selected from water dispersible complex particles through charge bonding with charged proteins and water dispersible complex particles through charge bonding between cations-charged polyethylenimine and anionic alginate. Limited to this It is not.
  • the lipid complex particles are complexes formed by physical or chemical bonds between lipid-based molecules and non-lipidic molecules, and include, but are not limited to, complexes formed by physically mixing DOLE (dioleolphosphatidyl ethanolamine) with hyaluronic acid or chemically through amide bonds. Any one or two or more lipid complexes selected from a complex formed by bonding to a complex, a complex formed by chemically bonding a ceramide and a water-soluble protein through an ester bond, and a complex formed by chemically bonding a dotap and a water-soluble protein to each other through an amide bond. May be, but is not limited thereto.
  • DOLE dioleolphosphatidyl ethanolamine
  • the active ingredient may be contained in the soluble polymer by being trapped or supported in various forms such as a core-shell type, a multi-shell type, and a porous type, for example.
  • the carrier may have various shapes such as a sphere or a polygon, but is not limited thereto.
  • the average size of the carrier may be 0.01 to 300 ⁇ m. Preferably it may be 0.1 to 100 ⁇ m, but is not limited thereto. If it has an average size of the above range is preferable because it can contain a sufficient effective ingredient.
  • the active ingredient may be, for example, an antiwrinkle agent, a slimming agent, a whitening agent, an antiacne agent, a moisturizer, or an anti-boring agent. It may include any one or two or more selected from (antiseborrhoeicagent), anti-aging agent (antiaging agent), keratolytic agent, antibacterial gent and antifungal gent.
  • the active ingredient may include a functional cosmetics notified raw material or an unnotified raw material compound.
  • the functional cosmetics notification raw materials are retinol, retinyl palmitate, adenosine, polyethoxylatedrite dretin amide, young mulberry extract, arbutin, echyl ascorbyl ether, oil-soluble licorice extract, ascorbyl glucoside, magnesium ascorbyl phosphate , Niacinamide, alpha-bisabolol, ascorbyl triisopalmitate and the like.
  • the notice material is ginseng extract, red ginseng extract, wild ginseng culture extract or fermented product, roe deer extract, rice bran or its extract, brown rice or its extract, green tea extract, Compound K, catechin, Icariside B2, It may be any one or two or more selected from Icarside B6 and isoflavones.
  • the active ingredient may be any one or a mixture thereof selected from organic germanium, alkylene glycols, glycerin, vitamins, plant extracts and derivatives thereof, but is not limited thereto.
  • the microneedle of the present invention may further include ingredients listed in the list of cosmetic raw materials and ICID (International Cosmetic Raw Materials Collection) registered in the Food and Drug Administration as being included in a common cosmetic composition.
  • the component may be uniformly distributed throughout the nonwoven sheet or the elastic body, and specifically, may further include any one or a mixture of two or more selected from a thickener, a pH adjuster, an emulsifier, a pigment, a perfume, and the like, but is not limited thereto. It is not.
  • carbomer As the thickener, carbomer, acrylate, ammonium acryloyldimethyl taurate-vinylpyrrolidone copolymer, acrylate-C 10 -C 30 alkyl acrylate crosspolymer, xanthan gum and cellulose gum can be used.
  • any one or two selected from powders of known minerals or grains for example, ocher, bentonite, tourmaline, ganbanite, calcium carbonate, rice bran, barley, wheat, buckwheat, brown rice, soybean, red beans, mung beans and corn powder The above mixture may be used, but is not limited thereto.
  • the pH regulator examples include organic acids such as citric acid, succinic acid, tartaric acid, lactic acid, malic acid, fumaric acid, maleic acid and glycolic acid; inorganic acids such as hydrochloric acid, sulfuric acid, phosphoric acid and nitric acid; sodium, potassium or ammonium salts of these acids, And it may be used any one or two or more selected from arginine and the like. In addition, one or a mixture of two or more selected from triethanolamine, sodium chloride, sodium hydroxide and potassium hydroxide may be used, but is not limited thereto.
  • the emulsifier is not limited as long as it is a raw material generally used in the art, but may be selected from cationic surfactants, anionic surfactants, amphoteric surfactants and nonionic surfactants, but is not limited thereto.
  • the pigments and fragrances can be used components commonly used in cosmetic compositions, but is not limited thereto.
  • the microneedle portion may be composed of a porous base portion and a plurality of soluble microneedles formed on the porous base portion.
  • the pressure applied to the microneedle through the elastic part may be uniformly dispersed in the microneedle.
  • the porous base portion supports the substrate, and the porous base portion may be provided with mechanical strength to the microneedle portion, and may have a rigid or flexible structure. If desired, another second substrate may be further provided.
  • the porous base may further have a through hole, through which the additional active ingredient may be delivered from the opposite side of the microneedle toward the skin.
  • the porous base portion may be a planar body having a predetermined thickness, and may be a resin film, a resin sheet, a fiber sheet of a woven or nonwoven structure.
  • the resin can be made of the same soluble polymer as the microneedle or of a different polymer.
  • any one selected from polyolefins, polyesters, polyamides, polyurethanes, polyimides, polyvinyl chlorides, and the like, or copolymers thereof may be included.
  • More specific examples include any one or two selected from polyethylene, polypropylene, polyvinyl chloride, polyethylene terephthalate (PET), polybutylene terephthalate (PBT), polyamide, polyurethane, polyimide, polyvinyl chloride, and the like. It may contain a mixture of the above.
  • the fiber sheet may also be made of the resin described above.
  • the porous base is not particularly limited, it is suitable for the purpose of the present invention to have a porosity of 1,000 to 20,000 g / m 2 ⁇ 24hr, more preferably of 6,000 to 15,000 g / m 2 ⁇ 24hr.
  • the porous base is not particularly limited, but may have pores having an average pore size of 0.01 to 500 ⁇ m, preferably 1 to 300 ⁇ m, so as to facilitate water supply or passage of the active ingredient. However, it is not limited thereto.
  • the height of the soluble microneedle may be 50 to 1,500 ⁇ m, and the thickness of the porous base of the microneedle may be 10 to 1,000 ⁇ m.
  • the soluble microneedle height may be 50 to 1,000 ⁇ m, and the thickness of the porous base of the microneedle may be 10 to 500 ⁇ m.
  • the elastic portion may be coupled to the microneedle portion.
  • the microneedle elastic structure coupled as described above is deformed to conform to the curved face, so that the pressure is transmitted to the entire face, and thus the effective ingredient can be delivered uniformly. There is an advantage that can be delivered to the active ingredient deep.
  • the elastic portion may be composed of an elastic body or an elastomer according to one aspect.
  • the elastomer or elastomer may mean a natural material itself having elastomeric properties, and may include a foam having elastomeric properties.
  • elastomer or elastomer examples include butadiene rubber, styrene-butadiene rubber, styrene-butadiene-styrene rubber, acrylonitrile rubber, acrylonitrile-butadiene rubber, acrylic rubber, ethylene-propylene-diene rubber, ethylene-propylene rubber It may include any one or a mixture of two or more selected from the group consisting of styrene-propylene rubber, silicone rubber, polyurethane rubber and hybrid silicone rubber.
  • the use of the elastomer or the elastomer of the present invention is a configuration that can solve the difficulty of transmitting the active ingredient to the deep skin is weak due to the force delivered to the pressure applied to the face is weak. Due to this, the microneedle elastic structure of the present invention is deformed to fit the curved face as it is combined with the elastic portion and the microneedle portion including the elastic body or the elastomer, so that pressure transmission is uniform throughout the face, thereby effectively delivering the active ingredient. By applying strong pressure on the hand, pressure can be easily delivered to the face, and active ingredients can be delivered deep into the skin.
  • the elastic body or elastomer has a compressive permanent shrinkage after compression measured at 70 ° C. for 168 hours based on ASTM D395, at 0.1 to 70%.
  • the compressive permanent shrinkage may be 0.1 to 50%.
  • the pressure is inserted into the skin and the elastic part immediately recovers after penetrating the microneedle, thereby shortening the time for the microneedles to stay in the skin, minimizing damage, irritation and foreign matter on the skin, thereby providing a very good touch.
  • the elastomer or elastomer may have a Shore Hardness 00 (shore 00) of 20 to 98 measured according to ASTM D2240. Preferably from 25 to 80, more preferably from 30 to 70.
  • Shore hardness 00 shore 00
  • the shape of the elastic part there is no limitation on the shape of the elastic part, and for example, the shape of the elastic part may be combined with the microneedle part without being limited in shape in addition to the spherical shape, the polygon, the rectangular parallelepiped, and the like.
  • the adhesive layer is urea, melamine, phenol, unsaturated polyester, epoxy, resorcinol, vinyl acetate, polyvinyl alcohol, vinyl chloride, saturated polyester, polyvinyl acetal, acrylic, poly Any one selected from the group consisting of amide, polyethylene, butadiene rubber, nitrile rubber, butyl rubber, silicone rubber, chloroprene rubber, vinyl, phenol-chloroprene, epoxidized nitrile rubber, glue, latex, rosin and shellac It may consist of one or more adhesives.
  • the adhesive of the present invention may be formed by applying an adhesive to a surface to which the microneedle portion and the elastic portion are coupled. It may be coated or partially applied. Preferably it can be applied by viscous coating. It is more economical than being applied to the front surface, and porosity and moisture permeability can be secured by front bonding.
  • the moisture supply part may form an empty space by adjusting the shape of the elastic part between the microneedle part and the elastic part, and position the water supply part in the empty space.
  • the water supply unit may be composed of an aqueous solution containing water or an active ingredient. Specifically, when the pressure is applied to the elastic part, the moisture inside the water supply part may leak and the active ingredient in the dissolved microneedles may be absorbed or impregnated into the skin.
  • the active ingredient can be delivered into the skin, which is more preferable.
  • microneedle elastic structure according to the present invention will be described in more detail with reference to the following examples.
  • the following examples are only one reference for describing the present invention in detail, and the present invention is not limited thereto and may be implemented in various forms.
  • the microneedle elastic structure when the microneedle elastic structure includes soluble microneedles, the soluble microneedles inserted into the skin by an aqueous solution containing water or an active ingredient applied to the skin or a water supply part inside the elastic structure. Dissolved and the effective ingredient is delivered to the dermis can express more excellent cosmetic effect.
  • the pressure applied to the elastic portion can be uniformly delivered to the microneedle portion, and the active ingredient can be delivered deeply to the skin, and the elastic structure is variably deformed even when used on the curved face by the elastic portion. As a result, the active ingredient may be uniformly delivered to the entire curved face.
  • the microneedle elastic structure is made of an elastic part comprising an elastic body or elastomer satisfying the compressive permanent shrinkage of 0.1 to 70% after compression for 168 hours at 70 °C based on ASTM D395
  • it has an excellent elastic recovery rate capable of transmitting sufficient force to penetrate the microneedle into the skin, and the active ingredient can be delivered deep into the skin.
  • the microelastic penetrates into the skin and thus returns to the skin without staying in the skin for a long time with excellent elastic recovery, thereby preventing damage and irritation to the skin and providing excellent touch with a little foreign body.
  • the active ingredient in the form of microcapsules in the microneedle when delivering the active ingredient in the form of microcapsules in the microneedle can be delivered in the skin without loss, the active ingredient provided in the skin is released slowly in the skin can be improved in the persistence of the effective ingredient effect.
  • the pressure of the elastic portion is transferred to dissolve the microneedles inserted into the skin more easily, and the moisture is transferred as the pressure of the elastic portion is directly transmitted.
  • the calendar is further improved and desirable.
  • porous base portion when the porous base portion is formed in the microneedle portion, it is better for skin insertion of the soluble microneedle with better pressure transfer.
  • the microneedle elastic structure of the present invention can provide an effective ingredient uniformly to curved skin, in particular, the face, and can provide a microneedle elastic structure that can easily deliver pressure to the active ingredient deep into the skin.
  • the microneedle portion bonded to the elastic portion is soluble, the microneedle is inserted into the skin and then dissolved by an aqueous solution containing water or an active ingredient applied to the skin to release the active ingredient contained in the microneedle portion. It can be easily delivered deep into the skin.
  • the microneedle elastic structure according to the present invention may exhibit a uniform and high cosmetic effect expression rate over the entire face, and thus may achieve an excellent effect even if it includes any active ingredient that can obtain a cosmetic effect.
  • the skin has excellent touch to less skin irritation and foreign body feeling, it showed an excellent preference in sensory evaluation.

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Abstract

The present invention relates to a micro needle elastic structure including a micro needle part in which a plurality of soluble micro needles are formed, and an elastic part coupled with the micro needle part.

Description

마이크로니들 탄성구조체Microneedle Elastic Structure
본 발명은 복수의 용해성 마이크로니들이 형성되는 마이크로니들부 및 상기 마이크로니들부와 결합되는 탄성부를 포함하는 마이크로니들 탄성구조체에 관한 것이다. The present invention relates to a microneedle elastic structure comprising a microneedle portion in which a plurality of soluble microneedles are formed and an elastic portion coupled to the microneedle portion.
종래에 피부표면 내에 수식효과 및 기능효과 중 적어도 한가지 효과를 부여하는 제제로서, 약효 성분을 함유한 액체물질, 연고제, 크림제, 테이프제, 패치제, 파프제(pap)등이 알려져 있다.Background Art Conventionally, liquid agents, ointments, creams, tapes, patches, papes, and the like, which contain an active ingredient, are known as agents for imparting at least one effect of modification and functional effects in the skin surface.
이들 제제는 피부에 바르거나 붙이는 등의 방법으로 사용된다. 이 때문에 사용 중의 발한, 세정, 외부압력 등에 의해 소실되거나 탈락하는 등의 결점이 있었다. 또한, 이들 제제는 제제 중의 약효 성분이 피부에 침투되어 체내에 확산됨으로써 처음으로 약효를 발휘한다. 하지만 피부표면층은 체내에 이물질이 침입하는 것을 방지하는 장벽기능을 가지고 있기에 약리효과를 발휘하기 위한 충분한 양의 약효성분을 흡수시키는 것은 곤란할 뿐만 아니라 피부표면층의 특정 부위에 유효성분을 확실하게 공급하는 것은 곤란하다.These agents are used by methods such as applying or applying to the skin. For this reason, there existed a fault, such as a loss or fall-off by sweating, washing | cleaning, external pressure, etc. during use. In addition, these preparations exert their first medicinal effects by infiltrating the skin with the active ingredient in the preparation and diffusing into the body. However, since the skin surface layer has a barrier function to prevent foreign substances from entering the body, it is difficult to absorb a sufficient amount of the active ingredient to exert a pharmacological effect, and it is difficult to reliably supply an active ingredient to a specific part of the skin surface layer. It is difficult.
또한, 미용 기술분야에 있어서는 피부표면에 화장제를 바른 후 경피투여시키기 위하여 초음파를 인가하는 초음파삼투법, 전기영동법 등이 채용되고 있다. 하지만 상술한 바와 같이 피부표면층은 체내에 이물질이 침입하는 것을 방지하는 장벽기능을 가지고 있기 때문에 충분한 양의 화장제를 투여하는 것은 어려운 일이다.In addition, in the cosmetic field, ultrasonic osmosis, electrophoresis, etc., in which ultrasonic waves are applied to transdermally administer a cosmetic agent to the skin surface, are employed. However, as described above, it is difficult to administer a sufficient amount of cosmetic since the skin surface layer has a barrier function to prevent foreign substances from entering the body.
최근에는 이런 문제들을 해결하고, 피부표면층의 특정 부위에 유효 성분을 확실하게 공급하는 방법으로서, 표면에 의약제나 화장제가 도포된 금속제 또는 플라스틱제 마이크로니들을 피부에 삽입시키는 방법이 이용되고 있다. 하지만 이 방법으로는 의약제나 화장제가 소량 밖에 투여되지 않을 뿐만 아니라 체내에 금속이나 플라스틱 마이크로니들이 잔존하는 사고가 종종 발생하기 때문에, 사람과 같은 생체에 의약제나 화장제를 투여하는 용도로서는 적합하지 않다.In recent years, as a method of solving these problems and reliably supplying an active ingredient to a specific part of the skin surface layer, a method of inserting metal or plastic microneedles with a medicament or a cosmetic applied to the surface is inserted into the skin. However, this method is not suitable for administering pharmaceuticals or cosmetics to humans such as humans, since only a small amount of pharmaceuticals and cosmetics are administered, and accidents in which metal or plastic microneedles remain in the body often occur.
이러한 문제를 해결하기 위하여, 피부를 롤러로 문질러 줌으로써 약물 전달의 효율성을 높이는 방식이 이용되었다. 그러나 이러한 방식은 롤러를 재사용해야 하므로 피부를 문지르는 과정에서 피부의 이물질이 롤러에서 부패하거나 다른 사람에게 옮겨 가는 등의 부작용을 갖는다. 또한, 굴곡진 얼굴을 롤러를 사용하여 마사지를 하는 과정에서 굴곡진 얼굴을 꼼꼼하게 마사지를 하기 어렵고 주기적인 세척을 통하여 청결을 유지해야 하지만 현실적으로 롤러의 세척이 어려운 문제가 있다.In order to solve this problem, a method of increasing the efficiency of drug delivery by rubbing the skin with a roller was used. However, since this method requires the roller to be reused, foreign matters on the skin in the process of rubbing the skin have a side effect such as decay from the roller or transfer to another person. In addition, it is difficult to massage the curved face meticulously in the process of massaging the curved face using the roller, and the cleanliness must be maintained through periodic cleaning, but the cleaning of the roller is difficult.
상기와 같은 문제점을 해결하기 위하여 본 발명은 피부표면층을 통과하여 유효성분을 피부 깊숙이 전달하기 위한 마이크로니들 탄성구조체를 제공하는 것을 목적으로 한다.In order to solve the above problems, an object of the present invention is to provide a microneedle elastic structure for delivering the active ingredient deep into the skin through the skin surface layer.
또한, 본 발명은 굴곡진 얼굴의 피부 전체에 고루 유효성분을 삽입할 수 있는 마이크로니들 탄성구조체를 제공하는 것을 목적으로 한다.In addition, an object of the present invention is to provide a microneedle elastic structure capable of inserting the active ingredient evenly throughout the skin of the curved face.
또한, 본 발명은 탄성부에 압력을 가하여 더욱 피부 깊숙이 유효성분을 전달할 수 있는 마이크로니들 탄성구조체를 제공하는 것을 목적으로 한다.In addition, an object of the present invention is to provide a microneedle elastic structure that can deliver the active ingredient further deep into the skin by applying pressure to the elastic portion.
또한, 본 발명은 피부에 도포된 수분 또는 유효성분을 포함하는 수용액에 의하여 마이크로니들이 용해되어 쉽게 피부로 전달될 수 있는 마이크로니들 탄성구조체를 제공하는 것을 목적으로 한다.In addition, an object of the present invention is to provide a microneedle elastic structure that can be easily transferred to the skin by dissolving the microneedle by an aqueous solution containing water or an active ingredient applied to the skin.
본 발명의 마이크로니들 탄성구조체는 복수의 용해성 마이크로니들이 형성되는 마이크로니들부 및 상기 마이크로니들부와 결합되는 탄성부를 포함할 수 있다.The microneedle elastic structure of the present invention may include a microneedle portion in which a plurality of soluble microneedles are formed and an elastic portion coupled to the microneedle portion.
본 발명의 일 양태에 따라 상기 용해성 마이크로니들은 피부에 도포된 물 또는 유효성분을 포함하는 수용액에 의하여 용해되는 것일 수 있다.According to an aspect of the present invention, the soluble microneedle may be dissolved by an aqueous solution containing water or an active ingredient applied to the skin.
본 발명의 일 양태에 따라 상기 마이크로니들부는 유효성분을 함유할 수 있다.According to an aspect of the present invention, the microneedle portion may contain an active ingredient.
본 발명의 일 양태에 따라 상기 마이크로니들부는 다공성 기저부와 상기 다공성 기저부상에 형성되는 복수의 용해성 마이크로니들로 이루어질 수 있다.According to an aspect of the present invention, the microneedle portion may be composed of a porous base portion and a plurality of soluble microneedles formed on the porous base portion.
본 발명의 일 양태에 따라 상기 용해성 마이크로니들은 아크릴계 중합체, 비닐알코올계 중합체, 비닐피롤리돈계 중합체, 셀룰로오스계 유도체, 알킬렌옥사이드계 중합체 및 다당체류에서 선택되는 어느 하나 또는 둘 이상의 혼합물일 수 있다.According to an aspect of the present invention, the soluble microneedle may be any one or a mixture of two or more selected from an acrylic polymer, a vinyl alcohol polymer, a vinylpyrrolidone polymer, a cellulose derivative, an alkylene oxide polymer and a polysaccharide. .
본 발명의 일 양태에 따라 상기 탄성부는 부타디엔 고무, 스티렌-부타디엔 고무, 스티렌-부타디엔-스티렌 고무, 아크릴로니트릴 고무, 아크릴로니트릴-부타디엔 고무, 아크릴 고무, 에틸렌-프로필렌-디엔 고무, 에틸렌-프로필렌 고무, 스티렌-프로필렌 고무, 실리콘 고무, 폴리우레탄 고무 및 하이브리드실리콘고무 등으로 이루어진 군에서 선택되는 어느 하나 또는 둘 이상의 혼합물을 포함할 수 있다.According to an aspect of the present invention, the elastic part is butadiene rubber, styrene-butadiene rubber, styrene-butadiene-styrene rubber, acrylonitrile rubber, acrylonitrile-butadiene rubber, acrylic rubber, ethylene-propylene-diene rubber, ethylene-propylene It may include any one or a mixture of two or more selected from the group consisting of rubber, styrene-propylene rubber, silicone rubber, polyurethane rubber and hybrid silicone rubber.
본 발명의 일 양태에 따라 상기 탄성부는 ASTM D395에 의거하여 측정된 압축영구줄음률이 0.1 내지 70%일 수 있다.According to an aspect of the present invention, the elastic portion may have a compressive permanent shrinkage measured in accordance with ASTM D395 of 0.1 to 70%.
본 발명의 일 양태에 따라 상기 마이크로니들부와 탄성부를 접착하는 접착층을 더 포함할 수 있다.According to an aspect of the present invention may further include an adhesive layer for bonding the microneedle portion and the elastic portion.
본 발명의 일 양태에 따라 상기 마이크로니들부와 탄성부 사이에 수분공급부를 더 포함할 수 있다.According to an aspect of the present invention may further include a water supply portion between the microneedle portion and the elastic portion.
본 발명의 일 양태에 따라 상기 탄성부에 압력을 가하면 수분공급부 내부의 수분이 누출되어 용해된 마이크로니들 내의 유효성분이 피부에 흡수 또는 함침되는 것일 수 있다.According to an aspect of the present invention, when the pressure is applied to the elastic part, the moisture inside the water supply part may leak and the active ingredient in the dissolved microneedles may be absorbed or impregnated into the skin.
본 발명에 따른 마이크로니들 탄성구조체는 피부표면층을 통과하여 피부 깊숙이 진피층까지 유효성분을 전달할 수 있다는 장점이 있다. The microneedle elastic structure according to the present invention has an advantage that the active ingredient can be delivered to the dermis layer deep through the skin surface layer.
또한, 본 발명에 따른 마이크로니들 탄성구조체는 굴곡진 얼굴의 빈틈없이 피부 전체에 고루 유효성분을 전달할 수 있다는 장점이 있다.In addition, the microneedle elastic structure according to the present invention has the advantage that it is possible to deliver the active ingredient evenly throughout the skin without the gap of the curved face.
또한, 본 발명에 따른 마이크로니들 탄성구조체는 탄성부에 압력을 가하면 피부전체에 압을 가할 수 있어 우수한 피부밀착력으로 더욱 피부 깊숙이 유효성분을 전달할 수 있다는 장점이 있다.In addition, the microneedle elastic structure according to the present invention has the advantage that can be applied to the entire skin when pressure is applied to the elastic portion can be delivered to the active ingredient deeper into the skin with excellent skin adhesion.
또한, 본 발명에 따른 마이크로니들 탄성구조체는 피부에 도포된 수분 또는 유효성분을 포함하는 수용액에 의하여 마이크로니들이 용해되어 쉽게 피부로 전달될 수 있다는 장점이 있다.In addition, the microneedle elastic structure according to the present invention has the advantage that the microneedle can be easily dissolved and delivered to the skin by an aqueous solution containing water or an active ingredient applied to the skin.
또한, 본 발명에 따른 마이크로니들 탄성구조체는 우수한 탄성회복력으로 피부 손상, 자극 및 이물감을 최소화하고, 우수한 촉감을 가질 수 있다는 장점이 있다. In addition, the microneedle elastic structure according to the present invention has the advantage of minimizing skin damage, irritation and foreign body with excellent elastic recovery power, and can have an excellent touch.
도 1은 본 발명의 일 실시예에 따른 마이크로니들 탄성구조체를 도시한 것이다.1 illustrates a microneedle elastic structure according to an embodiment of the present invention.
도 2는 본 발명의 또 다른 일 실시예에 따른 마이크로니들 탄성구조체를 도시한 것이다.2 illustrates a microneedle elastic structure according to another embodiment of the present invention.
도 3은 본 발명의 또 다른 일 실시예에 따른 마이크로니들 탄성구조체를 도시한 것이다.Figure 3 shows a microneedle elastic structure according to another embodiment of the present invention.
도 4는 본 발명의 또 다른 일 실시예에 따른 마이크로니들 탄성구조체를 도시한 것이다.Figure 4 illustrates a microneedle elastic structure according to another embodiment of the present invention.
도 5는 본 발명의 또 다른 일 실시예에 따른 마이크로니들 탄성구조체를 도시한 것이다.5 illustrates a microneedle elastic structure according to another embodiment of the present invention.
도 6은 본 발명의 또 다른 일 실시예에 따른 마이크로니들 탄성구조체를 도시한 것이다.6 illustrates a microneedle elastic structure according to another embodiment of the present invention.
도 7은 본 발명의 또 다른 일 실시예에 따른 마이크로니들 탄성구조체를 도시한 것이다.7 illustrates a microneedle elastic structure according to another embodiment of the present invention.
도 8은 본 발명의 일 실시예에 따른 퍼프형 마이크로니들 탄성구조체를 도시한 것이다.8 illustrates a puff-type microneedle elastic structure according to an embodiment of the present invention.
도 9는 본 발명의 일 실시예에 따른 골무형 마이크로니들 탄성구조체를 도시한 것이다.9 illustrates a bone microneedle elastic structure according to an embodiment of the present invention.
도 10은 본 발명의 일 실시예에 따른 롤러형 마이크로니들 탄성구조체를 도시한 것이다.Figure 10 illustrates a roller-type microneedle elastic structure according to an embodiment of the present invention.
*부호의 설명** Description of the sign *
1: 마이크로니들 2: 탄성부1: microneedle 2: elastic part
3: 접착층 4: 다공성 기저부 5: 수분공급부3: adhesive layer 4: porous base portion 5: moisture supply portion
이하 첨부한 도면들을 참조하여 본 발명의 구성에 대하여 상세히 설명한다. 다음에 소개되는 도면들은 당업자에게 본 발명의 사상이 충분히 전달될 수 있도록 예로서 제공되는 것이다. 따라서, 본 발명은 이하 제시되는 도면들에 한정되지 않고 다른 형태로 구체화될 수도 있으며, 이하 제시되는 도면들은 본 발명의 사상을 명확히 하기 위해 과장되어 도시될 수 있다. 이때, 사용되는 기술 용어 및 과학 용어에 있어서 다른 정의가 없다면, 이 발명이 속하는 기술 분야에서 통상의 지식을 가진 자가 통상적으로 이해하고 있는 의미를 가지며, 하기의 설명 및 첨부 도면에서 본 발명의 요지를 불필요하게 흐릴 수 있는 공지 기능 및 구성에 대한 설명은 생략한다.Hereinafter, the configuration of the present invention will be described in detail with reference to the accompanying drawings. The drawings introduced below are provided as examples to sufficiently convey the spirit of the present invention to those skilled in the art. Accordingly, the present invention is not limited to the drawings presented below and may be embodied in other forms, and the drawings presented below may be exaggerated to clarify the spirit of the present invention. At this time, if there is no other definition in the technical terms and scientific terms used, it has a meaning commonly understood by those of ordinary skill in the art to which the present invention belongs, the gist of the present invention in the following description and the accompanying drawings Descriptions of well-known functions and configurations that may be unnecessarily blurred are omitted.
이하는 본 발명에 대하여 도면을 참조하여 일 양태를 들어 설명을 하는 바, 본 발명이 이에 한정되는 것은 아니다.Hereinafter, the present invention will be described with reference to the drawings with reference to one embodiment, but the present invention is not limited thereto.
본 발명은 굴곡진 얼굴 전체에 고루 압력을 가할 수 있고, 피부 깊숙이 유효성분을 전달할 수 있는 마이크로니들 탄성구조체에 관한 것이다.The present invention relates to a microneedle elastic structure that can apply pressure evenly to the entire curved face and can deliver the active ingredient deep into the skin.
본 발명을 구체적으로 설명하면, 다음과 같다.The present invention will be described in detail as follows.
본 발명의 마이크로니들 탄성구조체는 복수의 용해성 마이크로니들이 형성되는 마이크로니들부 및 상기 마이크로니들부와 결합되는 탄성부를 포함할 수 있다.The microneedle elastic structure of the present invention may include a microneedle portion in which a plurality of soluble microneedles are formed and an elastic portion coupled to the microneedle portion.
이전에 마이크로니들 구조체들은 단단한 플라스틱 평면 형태의 마이크로니들구조체로써 굴곡진 얼굴에 전체적으로 균일한 압력을 가하기가 어렵고, 균일하게 유효성분이 얼굴 전체에 전달되기 어려웠다. 이를 해결하기 위하여 본 발명에서는 굴곡진 피부 특히, 얼굴에 균일하게 유효성분이 전달될 수 있고, 압력전달이 용이하여 피부 깊숙이까지 유효성분이 전달될 수 있는 마이크로니들 탄성구조체를 제조하였다. Previously, the microneedle structures are hard plastic flat microneedle structures, and it is difficult to apply uniform pressure to the curved face as a whole, and it is difficult to uniformly transmit effective ingredients throughout the face. In order to solve this problem, in the present invention, an effective ingredient can be uniformly delivered to curved skin, especially a face, and a microneedle elastic structure can be delivered to the active ingredient deeply through the skin by easy pressure transfer.
또한, 탄성부 상에 결합된 마이크로니들부가 용해성으로 구성되어 있어 마이크로니들이 피부에 삽입된 후 피부에 도포된 물 또는 유효성분을 포함하는 수용액에 의하여 용해됨으로써 마이크로니들부 내에 함유된 유효성분이 삽입된 상태로 방출되어 피부 깊숙이까지 쉽게 전달될 수 있다.In addition, the microneedle portion bonded to the elastic portion is composed of soluble so that the microneedle is inserted into the skin and dissolved by water or an aqueous solution containing the active ingredient applied to the skin is inserted into the active ingredient contained in the microneedle portion Can be released into the skin and delivered easily into the skin.
본 발명의 일 양태에 따라 상기 용해성 마이크로니들은 피부에 도포된 물 또는 유효성분을 포함하는 수용액에 의하여 용해되는 것일 수 있다. 상기와 같이 용해되기 위해서는 일 양태에 따라 상기 용해성 마이크로니들은 용해성 고분자를 포함하여 제조될 수 있고, 구체적으로는 물에 용해될 수 있는 수용성 고분자일 수 있으며, 피부에 도포되었을 때 피부에 자극되지 않고 무해한 고분자일 수 있다. 바람직하게는 아크릴계 중합체, 비닐알코올계 중합체, 비닐피롤리돈계 중합체, 셀룰로오스계 유도체, 알킬렌옥사이드계 중합체 및 다당체류에서 선택되는 어느 하나 또는 둘 이상의 혼합물일 수 있다. 구체적인 예를 들어,상기 아크릴계 중합체는 폴리아크릴아미드, 폴리메타아크릴레이트, 폴리에틸아크릴레이트, 폴리아크릴레이트, 폴리아크릴산 나트륨 및 아크릴산-메타크릴산 공중합체 등에서 선택될 수 있다. 상기 비닐알코올계 중합체는 폴리비닐알코올, 폴리비닐아세테이트 및 폴리비닐아세테이트-폴리비닐알코올 공중합체 등에서 선택될 수 있다. 상기 셀룰로오스 유도체는 셀룰로오스, 메틸셀룰로오스, 에틸셀룰로오스, 카르복시메틸셀룰로오스, 하이드록시에틸 셀룰로오스, 하이드록시프로필 메틸셀룰로오스, 셀룰로오스 아세테이트 및 셀룰로오스 아세테이트 프로피오네이트 등에서 선택될 수 있다. 상기 비닐피롤리돈 중합체는 폴리비닐피롤리돈 및 비닐피롤리돈을 포함하는 공중합체에서 선택될 수 있다. 상기 알킬렌옥사이드계 중합체는 폴리에틸렌옥사이드, 폴리에틸렌프로필렌글리콜, 폴리에틸렌글리콜디아크릴레이트, 폴리에틸렌글리콜디메틸에테르 및 폴리프로필렌옥사이드 등에서 선택될 수 있다. 상기 다당체류는 알지네이트, 전분, 잔탄검, 젤란검, 젤라틴, 키토산, 히알루론산, 덱스트란, 자일로즈, 수크로스, 말토오스, 락토오스, 트레할로스 및 키토산 등에서 선택되는 어느 하나 또는 둘 이상의 혼합물일 수 있으나, 이에 제한되는 것은 아니다.According to an aspect of the present invention, the soluble microneedle may be dissolved by an aqueous solution containing water or an active ingredient applied to the skin. In order to dissolve as described above, the soluble microneedles may be prepared by including a soluble polymer, specifically, may be a water-soluble polymer that can be dissolved in water, and is not irritated to the skin when applied to the skin. It may be a harmless polymer. Preferably, it may be any one or a mixture of two or more selected from an acrylic polymer, a vinyl alcohol polymer, a vinylpyrrolidone polymer, a cellulose derivative, an alkylene oxide polymer and a polysaccharide. For example, the acrylic polymer may be selected from polyacrylamide, polymethacrylate, polyethylacrylate, polyacrylate, sodium polyacrylate, acrylic acid-methacrylic acid copolymer, and the like. The vinyl alcohol polymer may be selected from polyvinyl alcohol, polyvinylacetate, and polyvinylacetate-polyvinyl alcohol copolymer. The cellulose derivative may be selected from cellulose, methyl cellulose, ethyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, cellulose acetate and cellulose acetate propionate. The vinylpyrrolidone polymer may be selected from copolymers comprising polyvinylpyrrolidone and vinylpyrrolidone. The alkylene oxide polymer may be selected from polyethylene oxide, polyethylene propylene glycol, polyethylene glycol diacrylate, polyethylene glycol dimethyl ether and polypropylene oxide. The polysaccharide may be any one or a mixture of two or more selected from alginate, starch, xanthan gum, gellan gum, gelatin, chitosan, hyaluronic acid, dextran, xylose, sucrose, maltose, lactose, trehalose and chitosan. It is not limited to this.
본 발명의 일 양태에 따라 상기 용해성 고분자는 중량평균분자량 1,000 내지 3,000,000 g/mol일 수 있고, 바람직하게는 중량평균분자량 5,000 내지 2,000,000 g/mol일 수 있으나, 이에 제한되는 것은 아니다. 상기 분자량을 가질 경우 물에 쉽게 용해되어 균질하게 용해성 고분자가 분산된 수용액이 제공되어 마이크로니들의 형상으로 제조가 용이하고, 마이크로니들 내에 균일하게 유효성분이 분산되어 제조될 수 있다.According to an aspect of the present invention, the soluble polymer may have a weight average molecular weight of 1,000 to 3,000,000 g / mol, preferably a weight average molecular weight of 5,000 to 2,000,000 g / mol, but is not limited thereto. When having the molecular weight, an aqueous solution in which the soluble polymer is dispersed homogeneously and easily dissolved in water is provided, thus making it easy to manufacture in the shape of a microneedle, and the active ingredient may be uniformly dispersed in the microneedle.
본 발명의 일 양태에 따라 상기 마이크로니들부는 유효성분을 함유할 수 있다. 피부에 도포된 유효성분은 모두 피부 내에 삽입하여 전달되기 어렵다. 이와 달리 본 발명의 일 양태에 따른 마이크로니들 탄성구조체는 마이크로니들 내에 유효성분을 함유함으로써, 피부에 마이크로니들이 삽입된 후 마이크로니들 내의 유효성분이 용출되어 피부 깊숙이 유효성분이 전달될 수 있다.According to an aspect of the present invention, the microneedle portion may contain an active ingredient. All active ingredients applied to the skin are difficult to be inserted into the skin and delivered. In contrast, the microneedle elastic structure according to an embodiment of the present invention contains an active ingredient in the microneedle, so that the active ingredient in the microneedle is eluted after the microneedle is inserted into the skin, so that the active ingredient can be delivered deep into the skin.
더욱 바람직하게는 본 발명의 일 양태에 따라 피부 진피까지 유효성분의 전달력을 높이기 위하여 상기 마이크로니들은 유효성분을 자체 함유하는 것도 가능하나, 유효성분이 함유된 마이크로입자, 마이크로캡슐, 전하복합체 입자 및 지질복합체 입자 등에서 선택되는 하나 이상의 전달체를 포함할 수도 있다.More preferably, in order to increase the delivery power of the active ingredient to the dermis of the skin according to an aspect of the present invention, the microneedle may contain the active ingredient itself, but the microparticles, microcapsules, charge complex particles, and the active ingredient may be contained. It may also comprise one or more carriers selected from lipid complex particles and the like.
상기와 같이 전달체는 상기 유효성분을 함유하는 것으로써, 용해성 고분자 내에 존재하여 유효성분의 부분별한 확산 및 손실이 방지될 수 있어 바람직하다. As described above, the carrier contains the active ingredient, and therefore, the carrier is present in the soluble polymer, so that partial diffusion and loss of the active ingredient can be prevented.
또한, 상기 전달체는 함유된 유효성분의 효과가 발현될 수 있는 피부 깊숙이까지 유효성분이 전달되어 피부에 효과적으로 미용효과가 발현될 수 있다.In addition, the carrier is delivered to the active ingredient deep into the skin can be expressed the effect of the active ingredient can be effectively expressed cosmetic effects on the skin.
상기 마이크로입자는 1 ㎜ 이하의 크기를 갖는 입자로써, 매트릭스가 균질하게 구형을 형성하는 입자로써, 구체적인 예를 들어 용해성 고분자가 균질하게 밀도를 갖는 구형의 입자 형상일 수 있으나, 이에 제한되는 것은 아니다. The microparticles are particles having a size of 1 mm or less, particles having a homogeneous spherical matrix, and may be, for example, spherical particles having a homogeneous density of soluble polymer, but are not limited thereto. .
싱기 마이크로캡슐은 유효성분으로 둘러싸인 코어를 함유하는 구형 마이크로캡슐을 의미하며, 구체적인 예를 들어, 유효성분을 코어에 함유하고 용해성 고분자를 쉘의 형태로 유효성분을 감싸안은 형상일 수 있으나, 이에 제한되는 것은 아니다.The thin microcapsule means a spherical microcapsule containing a core surrounded by an active ingredient. For example, the microcapsules may be a shape containing an active ingredient in a core and a soluble polymer in a shell form, but not limited thereto. It doesn't happen.
상기 전하복합체 입자는 서로 다른 전하를 가진 분자들이 물리적으로 결합되어 형성된 복합체이며, 비제한적인 예로, 음이온성 고분자와 양이온성 고분자가 서로 다른 전하를 통해 물리적으로 결합된 복합체 입자, 음이온으로 하전된 폴리에틸렌글리콜과 양이온으로 하전된 키토산과의 전하결합을 통한 수분산성 복합체 입자, 음이온으로 하전된 폴리에틸렌글리콜과 양이온으로 하전된 단백질과의 전하결합을 통한 수분산성 복합체 입자, 양이온으로 하전된 폴리에틸렌이민과 음이온으로 하전된 단백질과의 전하결합을 통한 수분산성 복합체 입자 및 양이온으로 하전된 폴리에틸렌이민과 음이온으로 하전된 알지네이트와의 전하결합을 통한 수분산성 복합체 입자 등에서 선택되는 어느 하나 또는 둘 이상의 전하복합체일 수 있으나, 이에 제한되는 것은 아니다.The charge composite particles are complexes formed by physically bonding molecules having different charges. For example, but not limited to, composite particles in which anionic polymers and cationic polymers are physically bonded through different charges, anion-charged polyethylene Water dispersible composite particles through charge bonding between glycol and cation charged chitosan, water dispersible composite particles through charge bonding between anion-charged polyethylene glycol and cation-charged protein, polyethyleneimine charged with cation and anion It may be any one or two or more charge complexes selected from water dispersible complex particles through charge bonding with charged proteins and water dispersible complex particles through charge bonding between cations-charged polyethylenimine and anionic alginate. Limited to this It is not.
상기 지질복합체 입자는 지질계 분자와 비지질계 분자가 물리적 또는 화학적 결합을 통해 형성된 복합체로서, 비제한적인 예로, DOPE(dioleolphosphatidyl ethanolamine)와 히알루론산이 물리적으로 혼합되어 형성된 복합체 또는 아미드결합을 통해 화학적으로 결합되어 형성된 복합체, 세라마이드와 수용성 단백질이 서로 에스테르결합을 통해 화학적으로 결합되어 형성된 복합체 및 dotap과 수용성 단백질이 서로 아미드결합을 통해 화학적으로 결합되어 형성된 복합체 등에서 선택되는 어느 하나 또는 둘이상의 지질복합체일 수 있으나, 이에 제한되는 것은 아니다.The lipid complex particles are complexes formed by physical or chemical bonds between lipid-based molecules and non-lipidic molecules, and include, but are not limited to, complexes formed by physically mixing DOLE (dioleolphosphatidyl ethanolamine) with hyaluronic acid or chemically through amide bonds. Any one or two or more lipid complexes selected from a complex formed by bonding to a complex, a complex formed by chemically bonding a ceramide and a water-soluble protein through an ester bond, and a complex formed by chemically bonding a dotap and a water-soluble protein to each other through an amide bond. May be, but is not limited thereto.
본 발명의 일 양태에 따라 상기 유효성분은 용해성 고분자 내에 존재하는 형상은 구체적인 예를 들어, 코어-쉘 형, 멀티-쉘형, 다공형 등의 다양한 형태로 용해성 고분자 내에 포획 또는 담지하여 함유될 수 있다. 또한, 상기 전달체는 구형 또는 다각형 등 다양한 모양을 가질 수 있으나, 이에 제한되는 것은 아니다.According to an aspect of the present invention, the active ingredient may be contained in the soluble polymer by being trapped or supported in various forms such as a core-shell type, a multi-shell type, and a porous type, for example. . In addition, the carrier may have various shapes such as a sphere or a polygon, but is not limited thereto.
또한, 일 양태에 따라 상기 전달체의 평균크기는 0.01 내지 300 ㎛일 수 있다. 바람직하게는 0.1 내지 100 ㎛일 수 있으나, 이에 제한되는 것은 아니다. 상기 범위의 평균크기를 가질 경우 충분한 유효성분을 함유할 수 있어 바람직하다.In addition, according to one aspect, the average size of the carrier may be 0.01 to 300 μm. Preferably it may be 0.1 to 100 ㎛, but is not limited thereto. If it has an average size of the above range is preferable because it can contain a sufficient effective ingredient.
본 발명의 일 양태에 따라 상기 유효성분은 예를 들어, 주름방지제(antiwrinkle agent), 슬리밍제(slimming agent), 미백제(whitening agent), 항 여드름제(antiacne agent), 보습제(moisturizer), 지루방지제(antiseborrhoeicagent), 노화방지제(antiaging agent), 각질분해제(keratolytic agent), 항균제(antibacterial gent) 및 항진균제(antifungal gent)등에서 선택되는 어느 하나 또는 둘 이상을 포함할 수 있다. According to an aspect of the present invention, the active ingredient may be, for example, an antiwrinkle agent, a slimming agent, a whitening agent, an antiacne agent, a moisturizer, or an anti-boring agent. It may include any one or two or more selected from (antiseborrhoeicagent), anti-aging agent (antiaging agent), keratolytic agent, antibacterial gent and antifungal gent.
상기 유효성분은 기능성화장품 고시 원료 또는 비고시 원료 화합물을 포함할 수 있다. 구체적인 예를 들어, 상기 기능성화장품 고시 원료는 레티놀, 레티닐팔미테이트, 아데노신, 폴리에톡실레이티드레틴아마이드, 닥나무추출물, 알부틴, 에칠아스코빌에텔, 유용성감초추출물, 아스코빌글루코사이드, 마그네슘아스코빌포스페이트, 나이아신아마이드, 알파-비사보롤 및 아스코빌테트라이소팔미테이트 등에서 선택되는 어느 하나 또는 둘 이상일 수 있다. 또한, 상기 비고시 원료는 인삼 추출물, 홍삼 추출물, 산삼배양 추출물 또는 그 발효물, 노루풀 추출물, 미강(rice bran) 또는 그 추출물, 현미 또는 그 추출물, 녹차 추출물, Compound K, 카테킨, Icariside B2, Icarside B6 및 이소플라본 등에서 선택되는 어느 하나 또는 둘 이상일 수 있다. The active ingredient may include a functional cosmetics notified raw material or an unnotified raw material compound. For example, the functional cosmetics notification raw materials are retinol, retinyl palmitate, adenosine, polyethoxylatedrite dretin amide, young mulberry extract, arbutin, echyl ascorbyl ether, oil-soluble licorice extract, ascorbyl glucoside, magnesium ascorbyl phosphate , Niacinamide, alpha-bisabolol, ascorbyl triisopalmitate and the like. In addition, the notice material is ginseng extract, red ginseng extract, wild ginseng culture extract or fermented product, roe deer extract, rice bran or its extract, brown rice or its extract, green tea extract, Compound K, catechin, Icariside B2, It may be any one or two or more selected from Icarside B6 and isoflavones.
이외에도 상기 유효성분으로써 유기게르마늄, 알킬렌글리콜류, 글리세린류, 비타민류, 식물 추출물 및 이들의 유도체 등에서 선택되는 어느 하나 또는 이들의 혼합물일 수 있으나, 이에 제한되는 것은 아니다.In addition, the active ingredient may be any one or a mixture thereof selected from organic germanium, alkylene glycols, glycerin, vitamins, plant extracts and derivatives thereof, but is not limited thereto.
본 발명의 상기 마이크로니들은 유효성분 외에도 통상의 화장료 조성물에 포함가능한 것으로 식품의약품안전청에 등록된 화장품 원료 리스트 및 ICID(국제화장품 원료집)에 등재되어 있는 성분을 더 포함할 수 있다. 상기 성분은 부직포 시트 또는 탄성체 전체에 균일하게 분포되어 포함될 수 있으며, 구체적으로, 점증제, pH 조절제, 유화제, 색소 및 향료 등에서 선택되는 어느 하나 또는 둘 이상의 혼합물을 더 포함할 수 있으나, 이에 제한되는 것은 아니다.In addition to the active ingredient, the microneedle of the present invention may further include ingredients listed in the list of cosmetic raw materials and ICID (International Cosmetic Raw Materials Collection) registered in the Food and Drug Administration as being included in a common cosmetic composition. The component may be uniformly distributed throughout the nonwoven sheet or the elastic body, and specifically, may further include any one or a mixture of two or more selected from a thickener, a pH adjuster, an emulsifier, a pigment, a perfume, and the like, but is not limited thereto. It is not.
상기 점증제로는 카보머, 아크릴레이트, 암모늄아크릴로일디메틸타우레이트-비닐피롤리돈 공중합체, 아크릴레이트-C10-C30알킬아크릴레이트크로스폴리머, 잔탄검 및 셀룰로오스검 등을 사용할 수 있으며, 이외에도 공지의 무기물 또는 곡물의 분말, 예를 들면, 황토, 벤토나이트, 토르마린, 맥반석, 칼슘 카보네이트, 쌀겨, 보리, 밀, 메밀, 현미, 콩, 팥, 녹두 및 옥수수의 분말 등에서 선택되는 어느 하나 또는 둘 이상의 혼합물을 사용할 수 있으나, 이에 제한되는 것은 아니다.As the thickener, carbomer, acrylate, ammonium acryloyldimethyl taurate-vinylpyrrolidone copolymer, acrylate-C 10 -C 30 alkyl acrylate crosspolymer, xanthan gum and cellulose gum can be used. In addition, any one or two selected from powders of known minerals or grains, for example, ocher, bentonite, tourmaline, ganbanite, calcium carbonate, rice bran, barley, wheat, buckwheat, brown rice, soybean, red beans, mung beans and corn powder The above mixture may be used, but is not limited thereto.
상기 pH 조절제로는 구연산, 숙신산, 타르타르산, 락트산, 말산, 푸마르산, 말레산, 글리콜산 등의 유기산;, 염산, 황산, 인산, 질산 등의 무기산;, 이들 산의 나트륨염, 칼륨염 또는 암모늄염, 및 알지닌 등에서 선택되는 어느 하나 또는 둘 이상을 혼합하여 사용할 수 있다. 또한, 트리에탄올아민, 소듐클로라이드, 수산화나트륨 및 수산화칼륨 등에서 선택되는 어느 하나 또는 둘 이상의 혼합물을 사용할 수도 있으나, 이에 제한되는 것은 아니다.Examples of the pH regulator include organic acids such as citric acid, succinic acid, tartaric acid, lactic acid, malic acid, fumaric acid, maleic acid and glycolic acid; inorganic acids such as hydrochloric acid, sulfuric acid, phosphoric acid and nitric acid; sodium, potassium or ammonium salts of these acids, And it may be used any one or two or more selected from arginine and the like. In addition, one or a mixture of two or more selected from triethanolamine, sodium chloride, sodium hydroxide and potassium hydroxide may be used, but is not limited thereto.
상기 유화제로는 당업계에서 일반적으로 사용되는 원료라면 한정되지 않으며, 양이온성 계면활성제, 음이온성 계면활성제, 양쪽성 계면활성제 및 비이온 계면활성제 등에서 선택되는 것일 수 있으나 이에 제한되는 것은 아니다. The emulsifier is not limited as long as it is a raw material generally used in the art, but may be selected from cationic surfactants, anionic surfactants, amphoteric surfactants and nonionic surfactants, but is not limited thereto.
상기 색소 및 향료는 통상적으로 화장료 조성물에 사용되는 성분들을 사용할 수 있으나, 이에 제한되는 것은 아니다.The pigments and fragrances can be used components commonly used in cosmetic compositions, but is not limited thereto.
본 발명의 일 양태에 따라 상기 마이크로니들부는 다공성 기저부와 상기 다공성 기저부상에 형성되는 복수의 용해성 마이크로니들로 이루어질 수 있다. 상기와 같이 마이크로니들을 지지해주기 위한 다공성 기저부를 포함할 경우 마이크로니들부에 탄성부를 통하여 가해지는 압력을 균일하게 마이크로니들에 분산시킬 수 있다. According to an aspect of the present invention, the microneedle portion may be composed of a porous base portion and a plurality of soluble microneedles formed on the porous base portion. In the case of including the porous base for supporting the microneedle as described above, the pressure applied to the microneedle through the elastic part may be uniformly dispersed in the microneedle.
상기 다공성 기저부는 일 양태에 따라 지지하는 기판으로, 다공성 기저부는 마이크로니들부에 기계적 강도가 제공될 수 있으며, 자체가 견고하거나 유연성(flexibility)을 가질 수 있다. 필요에 따라, 다른 제 2 기판이 더 제공될 수도 있다. 상기 다공성 기저부는 관통 홀을 더 가질 수 있으며, 상기 관통 홀을 통해 마이크로니들의 반대면으로부터 피부 쪽으로 추가적인 유효성분 전달이 이루어질 수도 있다.According to an aspect, the porous base portion supports the substrate, and the porous base portion may be provided with mechanical strength to the microneedle portion, and may have a rigid or flexible structure. If desired, another second substrate may be further provided. The porous base may further have a through hole, through which the additional active ingredient may be delivered from the opposite side of the microneedle toward the skin.
상기 다공성 기저부는 소정 두께를 갖는 면상체일 수 있으며, 수지 필름, 수지 시트, 직조 또는 부직포 구조의 섬유 시트일 수 있다. 상기 수지는 마이크로니들과 동일한 용해성 고분자이거나 상이한 고분자로 이루어 질 수 있다. 상이한 고분자일 경우 바람직하게는, 폴리올레핀계, 폴리에스테르계, 폴리아미드계, 폴리우레탄계, 폴리이미드계 및 폴리염화비닐계 등에서 선택되는 어느 하나 또는 이들의 공중합체를 포함할 수 있다. 더욱 구체적인 예를 들어, 폴리에틸렌, 폴리프로필렌, 폴리염화비닐, 폴리에틸렌테레프탈레이트(PET), 폴리부틸렌테레프탈레이트(PBT), 폴리아미드, 폴리우레탄, 폴리이미드, 폴리염화비닐 등에서 선택되는 어느 하나 또는 둘 이상의 혼합물을 포함할 수 있다. 또한, 상기 섬유 시트도 상술한 수지로 제조될 수 있다.The porous base portion may be a planar body having a predetermined thickness, and may be a resin film, a resin sheet, a fiber sheet of a woven or nonwoven structure. The resin can be made of the same soluble polymer as the microneedle or of a different polymer. In the case of different polymers, preferably, any one selected from polyolefins, polyesters, polyamides, polyurethanes, polyimides, polyvinyl chlorides, and the like, or copolymers thereof may be included. More specific examples include any one or two selected from polyethylene, polypropylene, polyvinyl chloride, polyethylene terephthalate (PET), polybutylene terephthalate (PBT), polyamide, polyurethane, polyimide, polyvinyl chloride, and the like. It may contain a mixture of the above. In addition, the fiber sheet may also be made of the resin described above.
상기 다공성 기저부는 특별히 제한되는 것은 아니지만, 투습도가 1,000 내지 20,000 g/㎡·24hr이고, 더 바람직하게는 투습도가 6,000 내지 15,000 g/㎡·24hr인 다공성을 갖는 것이 본 발명의 목적에 적합하다.Although the porous base is not particularly limited, it is suitable for the purpose of the present invention to have a porosity of 1,000 to 20,000 g / m 2 · 24hr, more preferably of 6,000 to 15,000 g / m 2 · 24hr.
또한, 상기 다공성 기저부는 특별히 제한되는 것은 아니만, 수분공급 또는 유효성분의 통과가 용이하도록 평균 기공크기가 0.01 내지 500 ㎛인 기공을 가질 수 있고, 바람직하게는 1 내지 300 ㎛인 기공을 가질 수 있으나, 이에 제한되는 것은 아니다. In addition, the porous base is not particularly limited, but may have pores having an average pore size of 0.01 to 500 μm, preferably 1 to 300 μm, so as to facilitate water supply or passage of the active ingredient. However, it is not limited thereto.
본 발명의 일 양태에 따라 특별히 제한되는 것은 아니지만, 상기 용해성 마이크로니들의 높이는 50 내지 1,500㎛일 수 있으며, 마이크로니들의 다공성 기저부의 두께는 10 내지 1,000 ㎛일 수 있다. 바람직하게는 용해성 마이크로니들 높이는 50 내지 1,000㎛일 수 있으며, 마이크로니들의 다공성 기저부의 두께는 10 내지 500 ㎛일 수 있다. 상기와 같이 제조될 경우 피부 삽입이 용이하고, 탄성부에서 가해지는 압력이 균일하게 전달될 수 있고, 유연성을 유지할 수 있다.Although not particularly limited according to one embodiment of the present invention, the height of the soluble microneedle may be 50 to 1,500 μm, and the thickness of the porous base of the microneedle may be 10 to 1,000 μm. Preferably, the soluble microneedle height may be 50 to 1,000 μm, and the thickness of the porous base of the microneedle may be 10 to 500 μm. When prepared as described above, it is easy to insert the skin, the pressure applied from the elastic portion can be transmitted uniformly, it can maintain flexibility.
본 발명의 일 양태에 따라 상기 탄성부는 상기 마이크로니들부에 결합될 수 있다. 상기와 같이 결합된 마이크로니들 탄성구조체는 굴곡진 얼굴에 맞추어 변형되면서 얼굴 전체에 압력전달이 되어 균일하게 유효성분이 전달될 수 있고, 손으로 강한 압력을 가하여 얼굴에 쉽게 압력이 전달될 수 있고, 피부 깊숙이까지 유효성분이 전달될 수 있는 장점이 있다. According to an aspect of the present invention, the elastic portion may be coupled to the microneedle portion. The microneedle elastic structure coupled as described above is deformed to conform to the curved face, so that the pressure is transmitted to the entire face, and thus the effective ingredient can be delivered uniformly. There is an advantage that can be delivered to the active ingredient deep.
이를 위하여 상기 탄성부는 일 양태에 따라, 탄성체 또는 엘라스토머로 구성될 수 있다. 바람직하게는 상기 탄성체 또는 엘라스토머는 엘라스토머적 특성을 갖는 본연의 물질 자체를 의미할 수 있고, 엘라스토머적 특성을 갖는 발포체를 포함할 수 있다. 구체적인 예를 들어 상기 탄성체 또는 엘라스토머는 부타디엔 고무, 스티렌-부타디엔 고무, 스티렌-부타디엔-스티렌 고무, 아크릴로니트릴 고무, 아크릴로니트릴-부타디엔 고무, 아크릴 고무, 에틸렌-프로필렌-디엔 고무, 에틸렌-프로필렌 고무, 스티렌-프로필렌 고무, 실리콘 고무, 폴리우레탄 고무 및 하이브리드실리콘고무 등으로 이루어진 군에서 선택되는 어느 하나 또는 둘 이상의 혼합물을 포함할 수 있다.To this end, the elastic portion may be composed of an elastic body or an elastomer according to one aspect. Preferably, the elastomer or elastomer may mean a natural material itself having elastomeric properties, and may include a foam having elastomeric properties. Specific examples of the elastomer or elastomer include butadiene rubber, styrene-butadiene rubber, styrene-butadiene-styrene rubber, acrylonitrile rubber, acrylonitrile-butadiene rubber, acrylic rubber, ethylene-propylene-diene rubber, ethylene-propylene rubber It may include any one or a mixture of two or more selected from the group consisting of styrene-propylene rubber, silicone rubber, polyurethane rubber and hybrid silicone rubber.
본 발명의 상기 탄성체 또는 엘라스토머의 사용은 얼굴에 가한 압력에 대한 전달되는 힘이 약하여 피부 깊숙이까지 유효성분이 미미하게 전달되는 어려움을 해결할 수 있는 구성이다. 이로 인하여 본 발명의 마이크로니들 탄성구조체는 탄성체 또는 엘라스토머를 포함하는 탄성부 및 마이크로니들부와 결합됨에 따라 굴곡진 얼굴에 맞추어 변형되면서 얼굴 전체에 압력전달이 균일하여 더욱 효과적으로 유효성분을 전달할 수 있고, 손으로 강한 압력을 가하여 얼굴에 쉽게 압력이 전달되고, 피부 깊숙이까지 유효성분이 전달될 수 있다.The use of the elastomer or the elastomer of the present invention is a configuration that can solve the difficulty of transmitting the active ingredient to the deep skin is weak due to the force delivered to the pressure applied to the face is weak. Due to this, the microneedle elastic structure of the present invention is deformed to fit the curved face as it is combined with the elastic portion and the microneedle portion including the elastic body or the elastomer, so that pressure transmission is uniform throughout the face, thereby effectively delivering the active ingredient. By applying strong pressure on the hand, pressure can be easily delivered to the face, and active ingredients can be delivered deep into the skin.
본 발명에서는 보다 좋게는 상기 탄성체 또는 엘라스토머는 ASTM D395에 의거하여 70℃, 168시간동안 측정된 압축 후의 압축영구줄음률이 0.1 내지 70%인 것이 더욱 좋다. 바람직하게는 압축영구줄음률이 0.1 내지 50%일 수 있다. 상기 범위의 압축영구줄음률을 갖는 탄성체 또는 엘라스토머는 피부에 압력이 전달될 때, 우수한 탄성회복률로 피부에 마이크로니들이 관통 되도록 힘이 충분히 전달되고, 피부 깊숙이까지 유효성분이 전달될 수 있다. 이와 동시에 피부에 삽입하는 압력이 가해져 마이크로니들이 관통 후 상기 탄성부는 즉시 회복능력을 가져 피부 속에 마이크로니들이 머무르는 시간을 단축시키고, 피부의 손상, 자극 및 이물감을 최소화하여 촉감이 매우 우수하다.In the present invention, more preferably, the elastic body or elastomer has a compressive permanent shrinkage after compression measured at 70 ° C. for 168 hours based on ASTM D395, at 0.1 to 70%. Preferably, the compressive permanent shrinkage may be 0.1 to 50%. When the elastic body or elastomer having a compressive permanent shrinkage in the above range is delivered to the skin, the force is sufficiently transmitted to allow microneedles to penetrate the skin with excellent elastic recovery rate, and the active ingredient can be delivered deep into the skin. At the same time, the pressure is inserted into the skin and the elastic part immediately recovers after penetrating the microneedle, thereby shortening the time for the microneedles to stay in the skin, minimizing damage, irritation and foreign matter on the skin, thereby providing a very good touch.
또한, 본 발명의 일 양태에 따라 상기 탄성체 또는 엘라스토머는 ASTM D2240에 의거하여 측정된 쇼어 경도 00(shore 00)가 20 내지 98일 수 있다. 바람직하게는 25 내지 80일 수 있고, 더 바람직하게는 30 내지 70일 수 있다. 상기 범위의 쇼어 경도를 가질 경우 피부의 자극을 방지하고, 굴곡진 얼굴 등과 같은 피부에서도 균일한 압력 전달에 의한 유효성분이 효율적으로 전달이 가능하다.In addition, according to an aspect of the present invention, the elastomer or elastomer may have a Shore Hardness 00 (shore 00) of 20 to 98 measured according to ASTM D2240. Preferably from 25 to 80, more preferably from 30 to 70. When having the Shore hardness of the above range to prevent the irritation of the skin, even in the skin such as a curved face, it is possible to efficiently deliver the effective ingredient by the uniform pressure transmission.
본 발명의 일 양태에 따라 상기 탄성부의 형상에는 제한이 없으며, 예를 들어, 구형, 다각형, 직육면체 등 이외에도 형상에 제한 없이 다양하게 가변적 형상으로 제조되어 마이크로니들부와 결합될 수 있다. 또한, 본 발명의 마이크로니들 탄성구조체의 탄성부에 끈, 손잡이 등을 연결하여 사용 시 마이크로니들 탄성구조체와 손과의 고정력을 향상시킬 수 있는 형상도 가능하다.According to an aspect of the present invention, there is no limitation on the shape of the elastic part, and for example, the shape of the elastic part may be combined with the microneedle part without being limited in shape in addition to the spherical shape, the polygon, the rectangular parallelepiped, and the like. In addition, it is also possible to improve the fixing force between the microneedle elastic structure and the hand when used by connecting a string, handle, etc. to the elastic portion of the microneedle elastic structure of the present invention.
본 발명의 일 양태에 따라 상기 마이크로니들부와 탄성부를 접착하는 접착층을 더 포함할 수 있다. 상기 접착층은 요소계, 멜라민계, 페놀계, 불포화 폴리에스테르계, 에폭시계, 레졸시놀계, 초산비닐계, 폴리비닐알코올계, 염화비닐계, 포화 폴리에스테르계, 폴리비닐아세탈계, 아크릴계, 폴리아미드계, 폴리에틸렌계, 부타디엔고무계, 니트릴고무계, 부틸고무계, 실리콘고무계, 클로로프렌고무계, 비닐계, 페놀-크로로프렌, 에폭시화 니트릴 고무계, 아교, 라텍스, 송진 및 셀락 등으로 이루어진 군에서 선택되는 어느 하나 또는 둘 이상의 접착제로 이루어질 수 있다.According to an aspect of the present invention may further include an adhesive layer for bonding the microneedle portion and the elastic portion. The adhesive layer is urea, melamine, phenol, unsaturated polyester, epoxy, resorcinol, vinyl acetate, polyvinyl alcohol, vinyl chloride, saturated polyester, polyvinyl acetal, acrylic, poly Any one selected from the group consisting of amide, polyethylene, butadiene rubber, nitrile rubber, butyl rubber, silicone rubber, chloroprene rubber, vinyl, phenol-chloroprene, epoxidized nitrile rubber, glue, latex, rosin and shellac It may consist of one or more adhesives.
본 발명의 상기 접착제는 마이크로니들부와 탄성부가 결합되는 면에 접착제를 도포하여 형성될 수 있다. 전면도포 또는 부분적으로 도포될 수 있다. 바람직하게는 점형 도포되어 접착될 수 있다. 이는 전면에 도포되는 것보다 경제적이며, 전면 접착에 의해 다공성, 투습성이 확보될 수 있다.The adhesive of the present invention may be formed by applying an adhesive to a surface to which the microneedle portion and the elastic portion are coupled. It may be coated or partially applied. Preferably it can be applied by viscous coating. It is more economical than being applied to the front surface, and porosity and moisture permeability can be secured by front bonding.
본 발명의 일 양태에 따라 상기 마이크로니들부와 탄성부 사이에 수분공급부를 더 포함할 수 있다. 상기 수분공급부를 마이크로니들부와 탄성부 사이에 탄성부의 형상을 조절하여 빈공간을 형성하고 상기 빈공간에 수분공급부를 위치시킬 수 있다. 상기와 같이 탄성부의 빈공간에 수분공급부를 가짐에 따라 탄성부에 가한 압력에 의하여 수분이 다공성 기저부를 통과하여 마이크로니들부에 공급될 수 있다. 상기 수분공급부는 물 또는 유효성분을 포함하는 수용액으로 구성될 수 있다. 구체적으로 상기 탄성부에 압력을 가하면 수분공급부 내부의 수분이 누출되어 용해된 마이크로니들 내의 유효성분이 피부에 흡수 또는 함침되는 것일 수 있다.According to an aspect of the present invention may further include a water supply portion between the microneedle portion and the elastic portion. The moisture supply part may form an empty space by adjusting the shape of the elastic part between the microneedle part and the elastic part, and position the water supply part in the empty space. As described above, as the moisture supply part is provided in the empty space of the elastic part, water may be supplied to the microneedle part through the porous base part by the pressure applied to the elastic part. The water supply unit may be composed of an aqueous solution containing water or an active ingredient. Specifically, when the pressure is applied to the elastic part, the moisture inside the water supply part may leak and the active ingredient in the dissolved microneedles may be absorbed or impregnated into the skin.
이에 따라 피부에 삽입된 마이크로니들이 용해되면서 유효성분이 피부 속으로 전달될 수 있어 더욱 바람직하다.Accordingly, as the microneedles inserted into the skin are dissolved, the active ingredient can be delivered into the skin, which is more preferable.
이하 실시예를 통해 본 발명에 따른 마이크로니들 탄성구조체에 대하여 더욱 상세히 설명한다. 다만 하기 실시예는 본 발명을 상세히 설명하기 위한 하나의 참조일 뿐 본 발명이 이에 한정되는 것은 아니며, 여러 형태로 구현될 수 있다. Hereinafter, the microneedle elastic structure according to the present invention will be described in more detail with reference to the following examples. However, the following examples are only one reference for describing the present invention in detail, and the present invention is not limited thereto and may be implemented in various forms.
또한 달리 정의되지 않은 한, 모든 기술적 용어 및 과학적 용어는 본 발명이 속하는 당업자 중 하나에 의해 일반적으로 이해되는 의미와 동일한 의미를 갖는다. 본원에서 설명에 사용되는 용어는 단지 특정 실시예를 효과적으로 기술하기 위함이고 본 발명을 제한하는 것으로 의도되지 않는다.Also, unless defined otherwise, all technical and scientific terms have the same meanings as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description herein is for the purpose of effectively describing particular embodiments only and is not intended to be limiting of the invention.
본 발명의 일 양태에 따라, 상기 마이크로니들 탄성구조체는 용해성 마이크로니들을 포함할 경우, 피부에 도포된 수분 또는 유효성분을 포함하는 수용액 또는 탄성구조체 내부의 수분공급부에 의하여 피부에 삽입된 용해성 마이크로니들이 용해되어 유효성분이 진피까지 전달되어 더욱 우수한 미용효과를 발현할 수 있다. 또한, 마이크로니들부와 탄성부가 결합됨에 따라 탄성부에 가해지는 압력이 마이크로니들부까지 균일하게 피부 깊숙이까지 유효성분이 전달될 수 있고, 탄성부에 의하여 굴곡진 얼굴에 사용되더라도 탄성구조체가 가변적으로 변형되어 굴곡진 얼굴 전체에 균일하게 유효성분이 전달될 수 있다.According to an aspect of the present invention, when the microneedle elastic structure includes soluble microneedles, the soluble microneedles inserted into the skin by an aqueous solution containing water or an active ingredient applied to the skin or a water supply part inside the elastic structure. Dissolved and the effective ingredient is delivered to the dermis can express more excellent cosmetic effect. In addition, as the microneedle portion and the elastic portion are coupled, the pressure applied to the elastic portion can be uniformly delivered to the microneedle portion, and the active ingredient can be delivered deeply to the skin, and the elastic structure is variably deformed even when used on the curved face by the elastic portion. As a result, the active ingredient may be uniformly delivered to the entire curved face.
더욱이, 본 발명의 일 양태에 따라, 상기 마이크로니들 탄성구조체는 ASTM D395에 의거하여 70℃에서 168시간동안 압축 후 압축영구줄음률이 0.1 내지 70%를 만족하는 탄성체 또는 엘라스토머를 포함하는 탄성부로 이루어질 경우, 피부에 마이크로니들이 관통될 수 있는 충분한 힘 전달이 가능한 우수한 탄성회복률을 가지고, 피부 깊숙이까지 유효성분이 전달될 수 있다. 또한, 피부에 마이크로니틀 관통 후 우수한 탄성회복력으로 피부 속에 오래 머무르지 않고 되돌아오기 때문에 피부에 손상 및 자극을 방지하고, 적은 이물감으로 우수한 촉감을 제공할 수 있다.Furthermore, according to one aspect of the invention, the microneedle elastic structure is made of an elastic part comprising an elastic body or elastomer satisfying the compressive permanent shrinkage of 0.1 to 70% after compression for 168 hours at 70 ℃ based on ASTM D395 In this case, it has an excellent elastic recovery rate capable of transmitting sufficient force to penetrate the microneedle into the skin, and the active ingredient can be delivered deep into the skin. In addition, the microelastic penetrates into the skin and thus returns to the skin without staying in the skin for a long time with excellent elastic recovery, thereby preventing damage and irritation to the skin and providing excellent touch with a little foreign body.
또한, 마이크로니들 내에 마이크로캡슐 형상으로 유효성분을 전달할 경우 손실없이 피부 내에 전달할 수 있고, 피부 내 제공된 유효성분이 피부 내에서 서서히 방출되어 유효성분 효과의 지속성이 향상될 수 있다. In addition, when delivering the active ingredient in the form of microcapsules in the microneedle can be delivered in the skin without loss, the active ingredient provided in the skin is released slowly in the skin can be improved in the persistence of the effective ingredient effect.
또한, 마이크로니들부와 탄성부 사이에 수분공급부가 제공할 경우, 탄성부의 압력이 전달되어 피부에 삽입된 마이크로니들을 더욱 용이하게 용해시킬 수 있고, 탄성부의 압력을 직접으로 전달받음에 따라 수분전달력이 더욱 향상되어 바람직하다.In addition, when the water supply portion is provided between the microneedle portion and the elastic portion, the pressure of the elastic portion is transferred to dissolve the microneedles inserted into the skin more easily, and the moisture is transferred as the pressure of the elastic portion is directly transmitted. The calendar is further improved and desirable.
또한, 마이크로니들부에 다공성 기저부를 형성할 경우 더욱 우수한 압력전달로 용해성 마이크로니들의 피부삽입에 더욱 좋다.In addition, when the porous base portion is formed in the microneedle portion, it is better for skin insertion of the soluble microneedle with better pressure transfer.
따라서, 본 발명의 마이크로니들 탄성구조체는 굴곡진 피부 특히, 얼굴에 균일하게 유효성분을 전달할 수 있고, 압력전달이 용이하여 피부 깊숙이까지 유효성분을 전달할 수 있는 마이크로니들 탄성구조체를 제공할 수 있다.Accordingly, the microneedle elastic structure of the present invention can provide an effective ingredient uniformly to curved skin, in particular, the face, and can provide a microneedle elastic structure that can easily deliver pressure to the active ingredient deep into the skin.
또한, 탄성부 상에 결합된 마이크로니들부가 용해성으로 구성될 경우, 마이크로니들이 피부에 삽입된 후 피부에 도포된 물 또는 유효성분을 포함하는 수용액에 의하여 용해되어 마이크로니들부 내에 함유된 유효성분이 방출되어 피부 깊숙이까지 쉽게 전달될 수 있다.In addition, when the microneedle portion bonded to the elastic portion is soluble, the microneedle is inserted into the skin and then dissolved by an aqueous solution containing water or an active ingredient applied to the skin to release the active ingredient contained in the microneedle portion. It can be easily delivered deep into the skin.
이에 본 발명에 따른 마이크로니들 탄성구조체는 얼굴 전체에 균일하고 높은 미용효과 발현율을 나타낼 수 있어 미용적 효과를 얻을 수 있는 어떠한 유효성분을 포함하여도 우수한 효과를 달성할 수 있다. 또한, 적은 피부 자극 및 이물감에 우수한 촉감을 가짐에 따라 관능성 평가 시 선호도가 우수함을 나타내었다.Accordingly, the microneedle elastic structure according to the present invention may exhibit a uniform and high cosmetic effect expression rate over the entire face, and thus may achieve an excellent effect even if it includes any active ingredient that can obtain a cosmetic effect. In addition, as the skin has excellent touch to less skin irritation and foreign body feeling, it showed an excellent preference in sensory evaluation.
이상과 같이 본 발명에서는 특정된 사항들과 한정된 마이크로니들 탄성구조체가 설명되었으나, 이는 본 발명의 보다 전반적인 이해를 돕기 위해서 제공된 것일 뿐, 본 발명이 속하는 분야에서 통상의 지식을 가진 자라면 이러한 기재로부터 다양한 수정 및 변형이 가능하다. As described above, in the present invention, specific matters and limited microneedle elastic structures have been described, but these are provided only to help a more general understanding of the present invention. Various modifications and variations are possible.
따라서, 본 발명의 사상은 국한되어 정해져서는 아니되며, 후술하는 특허청구범위뿐 아니라 이 특허청구범위와 균등하거나 등가적 변형이 있는 모든 것들은 본 발명 사상의 범주에 속한다고 할 것이다.Accordingly, the spirit of the present invention should not be limited and defined, and not only the claims to be described later but all those having equivalent or equivalent modifications to the claims shall belong to the scope of the present invention.

Claims (10)

  1. 복수의 용해성 마이크로니들이 형성되는 마이크로니들부 및A microneedle portion in which a plurality of soluble microneedles are formed;
    상기 마이크로니들부와 결합되는 탄성부를 포함하는 마이크로니들 탄성구조체.Microneedle elastic structure comprising an elastic portion coupled to the microneedle portion.
  2. 제 1항에 있어서,The method of claim 1,
    상기 용해성 마이크로니들은 피부에 도포된 물 또는 유효성분을 포함하는 수용액에 의하여 용해되는 것인 마이크로니들 탄성구조체.The soluble microneedle is a microneedle elastic structure that is dissolved by an aqueous solution containing water or an active ingredient applied to the skin.
  3. 제 1항에 있어서,The method of claim 1,
    상기 마이크로니들부는 유효성분을 함유하는 마이크로니들 탄성구조체.The microneedle portion microneedle elastic structure containing the active ingredient.
  4. 제 1항에 있어서,The method of claim 1,
    상기 마이크로니들부는 다공성 기저부와 상기 다공성 기저부상에 형성되는 복수의 용해성 마이크로니들로 이루어진 마이크로니들 탄성구조체.The microneedle portion is a microneedle elastic structure consisting of a porous base portion and a plurality of soluble microneedle formed on the porous base portion.
  5. 제 1항에 있어서,The method of claim 1,
    상기 용해성 마이크로니들은 아크릴계 중합체, 비닐알코올계 중합체, 비닐피롤리돈계 중합체, 셀룰로오스계 유도체, 알킬렌옥사이드계 중합체 및 다당체류에서 선택되는 어느 하나 또는 둘 이상의 혼합물인 마이크로니들 탄성구조체.The soluble microneedle is a microneedle elastic structure of any one or two or more selected from acrylic polymer, vinyl alcohol-based polymer, vinylpyrrolidone-based polymer, cellulose derivative, alkylene oxide-based polymer and polysaccharides.
  6. 제1항에 있어서, The method of claim 1,
    상기 탄성부는 부타디엔 고무, 스티렌-부타디엔 고무, 스티렌-부타디엔-스티렌 고무, 아크릴로니트릴 고무, 아크릴로니트릴-부타디엔 고무, 아크릴 고무, 에틸렌-프로필렌-디엔 고무, 에틸렌-프로필렌 고무, 스티렌-프로필렌 고무, 실리콘 고무, 폴리우레탄 고무 및 하이브리드실리콘 고무로 이루어진 군에서 선택되는 어느 하나 또는 둘 이상의 혼합물을 포함하는 마이크로니들 탄성구조체.The elastic part is butadiene rubber, styrene-butadiene rubber, styrene-butadiene-styrene rubber, acrylonitrile rubber, acrylonitrile-butadiene rubber, acrylic rubber, ethylene-propylene-diene rubber, ethylene-propylene rubber, styrene-propylene rubber, Microneedle elastic structure comprising any one or a mixture of two or more selected from the group consisting of silicone rubber, polyurethane rubber and hybrid silicone rubber.
  7. 제 1항에 있어서,The method of claim 1,
    상기 탄성부는 ASTM D395에 의거하여 측정된 압축영구줄음률이 0.1 내지 70%인 마이크로니들 탄성구조체.The elastic portion of the microneedle elastic structure having a compressive permanent shrinkage of 0.1 to 70% measured according to ASTM D395.
  8. 제 1항에 있어서,The method of claim 1,
    상기 마이크로니들부와 탄성부를 접착하는 접착층을 더 포함하는 마이크로니들 탄성구조체.Microneedle elastic structure further comprising an adhesive layer for bonding the microneedle portion and the elastic portion.
  9. 제 1항에 있어서,The method of claim 1,
    상기 마이크로니들부와 탄성부 사이에 수분공급부를 더 포함하는 마이크로니들 탄성구조체.Microneedle elastic structure further comprising a water supply between the microneedle portion and the elastic portion.
  10. 제 9항에 있어서,The method of claim 9,
    상기 탄성부에 압력을 가하면 수분공급부 내부의 수분이 누출되어 용해된 마이크로니들 내의 유효성분이 피부에 흡수 또는 함침되는 것인 마이크로니들 탄성구조체.When the pressure is applied to the elastic part, the microneedle elastic structure in which water inside the water supply part leaks and the active ingredient in the dissolved microneedle is absorbed or impregnated into the skin.
PCT/KR2018/006544 2017-06-09 2018-06-08 Micro needle elastic structure WO2018226069A1 (en)

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KR10-2017-0072332 2017-06-09
KR20170072332 2017-06-09
KR1020180045526A KR101976431B1 (en) 2017-06-09 2018-04-19 Micro needle elastic structure
KR10-2018-0045526 2018-04-19

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080007084A (en) * 2006-07-14 2008-01-17 호남석유화학 주식회사 Skin pricking micro projection apparatus having reservoir space of materials for transdermal delivery in front side
US8062573B2 (en) * 2002-09-16 2011-11-22 Theraject, Inc. Solid micro-perforators and methods of use
KR101549086B1 (en) * 2014-11-10 2015-09-02 주식회사 스몰랩 Micro-needle and micro-needle patch
KR101703050B1 (en) * 2014-07-10 2017-02-07 주식회사 주빅 Protruding Microstructure for Transdermal Delivery
KR20170040767A (en) * 2015-10-05 2017-04-13 주식회사 엘지생활건강 Soluble microneedle mask kit

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8062573B2 (en) * 2002-09-16 2011-11-22 Theraject, Inc. Solid micro-perforators and methods of use
KR20080007084A (en) * 2006-07-14 2008-01-17 호남석유화학 주식회사 Skin pricking micro projection apparatus having reservoir space of materials for transdermal delivery in front side
KR101703050B1 (en) * 2014-07-10 2017-02-07 주식회사 주빅 Protruding Microstructure for Transdermal Delivery
KR101549086B1 (en) * 2014-11-10 2015-09-02 주식회사 스몰랩 Micro-needle and micro-needle patch
KR20170040767A (en) * 2015-10-05 2017-04-13 주식회사 엘지생활건강 Soluble microneedle mask kit

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