KR101976431B1 - Micro needle elastic structure - Google Patents
Micro needle elastic structure Download PDFInfo
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- KR101976431B1 KR101976431B1 KR1020180045526A KR20180045526A KR101976431B1 KR 101976431 B1 KR101976431 B1 KR 101976431B1 KR 1020180045526 A KR1020180045526 A KR 1020180045526A KR 20180045526 A KR20180045526 A KR 20180045526A KR 101976431 B1 KR101976431 B1 KR 101976431B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
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Abstract
The present invention relates to a micro needle elastic structure including a micro needle portion in which a plurality of soluble micro needles are formed and an elastic portion coupled with the micro needle portion.
Description
The present invention relates to a micro needle elastic structure including a micro needle portion in which a plurality of soluble micro needles are formed and an elastic portion coupled with the micro needle portion.
BACKGROUND ART [0002] Conventionally known as a preparation for imparting at least one of a modifying effect and a functional effect to the surface of a skin is a liquid substance containing an active ingredient, an ointment preparation, a cream preparation, a tape preparation, a patch preparation, a pap and the like.
These preparations are used in a manner such as applying or sticking to the skin. For this reason, there are disadvantages such as sweating during use, cleaning, and loss or dropping due to external pressure. In addition, these pharmaceutical preparations are effective for the first time since the active ingredient in the preparation penetrates into the skin and diffuses into the body. However, since the skin surface layer has a barrier function to prevent foreign matter from entering the body, it is difficult to absorb a sufficient amount of the active ingredient to exert a pharmacological effect, and it is also difficult to reliably supply the effective ingredient to a specific site of the skin surface layer It is difficult.
In the field of cosmetic technology, ultrasonic osmotic method and electrophoresis method in which ultrasonic waves are applied for transdermal administration after applying a cosmetic agent to the skin surface are employed. However, as described above, since the skin surface layer has a barrier function to prevent foreign matter from entering the body, it is difficult to administer a sufficient amount of cosmetic agent.
Recently, as a method of solving these problems and reliably supplying an effective ingredient to a specific site on the surface layer of the skin, a method of inserting a metal or plastic microneedle coated with a medicine or a cosmetic on the skin has been used. However, this method is not suitable for administering medicines or cosmetics to living bodies such as humans, because medicines and cosmetics are only administered in small quantities, and metal or plastic micro-needles are often left in the body.
To solve this problem, a method of increasing the efficiency of drug delivery by rubbing the skin with a roller was used. However, this method has a side effect such that the foreign substances of the skin are rotten on the rollers or transferred to another person in the process of rubbing the skin because the rollers must be reused. In addition, it is difficult to massively massage the curved face in the process of massaging the curved face using the roller, and it is necessary to maintain the cleanliness through periodic cleaning, but there is a problem that the roller is difficult to be washed practically.
In order to solve the above-mentioned problems, it is an object of the present invention to provide a micro needle elastic structure for passing an active ingredient deep into the skin through a skin surface layer.
It is another object of the present invention to provide a micro needle elastic structure capable of evenly inserting an active ingredient into the entire skin of a curved face.
It is another object of the present invention to provide a micro needle elastic structure capable of transferring an active ingredient deep into the skin by applying pressure to the elastic portion.
It is another object of the present invention to provide a micro needle elastic structure which can dissolve micro-needles by an aqueous solution containing water or an active ingredient applied to the skin and can be easily delivered to the skin.
The micro needle elastic structure of the present invention may include a micro needle portion in which a plurality of soluble micro needles are formed and an elastic portion coupled with the micro needle portion.
According to an embodiment of the present invention, the soluble micro-needle may be dissolved in an aqueous solution containing water or an active ingredient applied to the skin.
According to one aspect of the present invention, the micro needle portion may contain an active ingredient.
According to an aspect of the present invention, the microneedle portion may include a porous base and a plurality of soluble micro-needles formed on the porous base.
According to one embodiment of the present invention, the soluble micro needle may be any one or a mixture of two or more selected from acrylic polymer, vinyl alcohol polymer, vinyl pyrrolidone polymer, cellulose derivative, alkylene oxide polymer and polysaccharide .
According to one aspect of the present invention, the elastic portion may be at least one selected from the group consisting of butadiene rubber, styrene-butadiene rubber, styrene-butadiene-styrene rubber, acrylonitrile rubber, acrylonitrile-butadiene rubber, acrylic rubber, ethylene- A rubber, a styrene-propylene rubber, a silicone rubber, a polyurethane rubber, a hybrid silicone rubber, and the like.
According to one embodiment of the present invention, the elastic part may have a compression set value of 0.1 to 70% as measured according to ASTM D395.
According to an aspect of the present invention, an adhesive layer for adhering the micro needle portion and the elastic portion may be further included.
According to an aspect of the present invention, a moisture supply unit may further be provided between the micro needle portion and the elastic portion.
According to an embodiment of the present invention, when pressure is applied to the elastic portion, moisture in the moisture supply portion leaks and the effective ingredient in the dissolved micro needle can be absorbed or impregnated into the skin.
The micro needle elastic structure according to the present invention is advantageous in that an effective ingredient can be delivered to the dermis layer deep into the skin through the skin surface layer.
In addition, the micro needle elastic structure according to the present invention has an advantage that the effective ingredient can be uniformly distributed throughout the skin without a curved face.
In addition, the micro needle elastic structure according to the present invention is capable of applying pressure to the entire skin when a pressure is applied to the elastic part, and is capable of delivering the active ingredient deep into the skin due to excellent skin adhesion.
In addition, the micro needle elastic structure according to the present invention is advantageous in that the micro needle is dissolved by the aqueous solution containing the water or the active ingredient applied to the skin and can be easily transferred to the skin.
In addition, the micro needle elastic structure according to the present invention has an advantage of minimizing skin damage, irritation, and foreign body sensation with excellent elastic recovery force, and having excellent touch feeling.
1 shows a micro needle elastic structure according to an embodiment of the present invention.
2 shows a micro needle elastic structure according to another embodiment of the present invention.
3 illustrates a micro needle elastic structure according to another embodiment of the present invention.
4 illustrates a micro needle elastic structure according to another embodiment of the present invention.
5 illustrates a micro needle elastic structure according to another embodiment of the present invention.
6 illustrates a micro needle elastic structure according to another embodiment of the present invention.
7 illustrates a micro needle elastic structure according to another embodiment of the present invention.
8 illustrates a puff type micro needle elastic structure according to an embodiment of the present invention.
FIG. 9 illustrates a bone-like micro needle elastic structure according to an embodiment of the present invention.
10 illustrates a roller type micro needle elastic structure according to an embodiment of the present invention.
Hereinafter, the configuration of the present invention will be described in detail with reference to the accompanying drawings. The following drawings are provided by way of example so that those skilled in the art can fully understand the spirit of the present invention. Therefore, the present invention is not limited to the following drawings, but may be embodied in other forms, and the following drawings may be exaggerated in order to clarify the spirit of the present invention. Hereinafter, the technical and scientific terms used herein will be understood by those skilled in the art without departing from the scope of the present invention. Descriptions of known functions and configurations that may be unnecessarily blurred are omitted.
Hereinafter, the present invention will be described in detail with reference to the drawings, but the present invention is not limited thereto.
The present invention relates to a micro needle elastic structure capable of applying uniform pressure to the entire curved face and capable of delivering an effective ingredient deep into the skin.
The present invention will be described in detail as follows.
The micro needle elastic structure of the present invention may include a micro needle portion in which a plurality of soluble micro needles are formed and an elastic portion coupled with the micro needle portion.
Previously, the microneedle structures were difficult to apply a uniformly uniform overall pressure to the curved face with a micro-needle structure in the form of a rigid plastic plane, and the effective ingredient was not uniformly distributed throughout the face. In order to solve this problem, the present invention provides a micro needle elastic structure capable of uniformly delivering an active ingredient to a curved skin, particularly a face, and transmitting an effective ingredient to the deep part of the skin with ease of pressure transmission.
In addition, since the micro needle portion attached on the elastic portion is constituted by solubility, the micro needle is inserted into the skin and dissolved by the water or the aqueous solution containing the active ingredient, so that the effective ingredient contained in the micro needle portion is inserted And can be easily delivered deep into the skin.
According to an embodiment of the present invention, the soluble micro-needle may be dissolved in an aqueous solution containing water or an active ingredient applied to the skin. In order to dissolve as described above, the soluble micro needle can be prepared by including a soluble polymer, specifically, a water-soluble polymer that can be dissolved in water, and is not stimulated to the skin when it is applied to the skin It can be a harmless polymer. Preferably, it may be any one or a mixture of two or more selected from acrylic polymers, vinyl alcohol polymers, vinyl pyrrolidone polymers, cellulose derivatives, alkylene oxide polymers and polysaccharides. For example, the acrylic polymer may be selected from polyacrylamide, polymethacrylate, polyethylacrylate, polyacrylate, sodium polyacrylate, and acrylic acid-methacrylic acid copolymer. The vinyl alcohol polymer may be selected from polyvinyl alcohol, polyvinyl acetate, polyvinyl acetate-polyvinyl alcohol copolymer, and the like. The cellulose derivative may be selected from cellulose, methylcellulose, ethylcellulose, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, cellulose acetate and cellulose acetate propionate. The vinylpyrrolidone polymer may be selected from copolymers comprising polyvinylpyrrolidone and vinylpyrrolidone. The alkylene oxide polymer may be selected from polyethylene oxide, polyethylene propylene glycol, polyethylene glycol diacrylate, polyethylene glycol dimethyl ether, and polypropylene oxide. The polysaccharide may be any one or a mixture of two or more selected from alginate, starch, xanthan gum, gellan gum, gelatin, chitosan, hyaluronic acid, dextran, xylose, sucrose, maltose, lactose, trehalose, chitosan, But is not limited thereto.
According to an embodiment of the present invention, the soluble polymer may have a weight average molecular weight of 1,000 to 3,000,000 g / mol, and preferably has a weight average molecular weight of 5,000 to 2,000,000 g / mol, but is not limited thereto. When the above-mentioned molecular weight is provided, an aqueous solution which is easily dissolved in water and homogeneously dispersed with the soluble polymer is provided, so that the preparation can be easily performed in the form of micro needle, and the active ingredient can be uniformly dispersed in the micro needle.
According to one aspect of the present invention, the micro needle portion may contain an active ingredient. All of the active ingredients applied to the skin are difficult to be inserted and transferred into the skin. Alternatively, the micro needle elastic structure according to an embodiment of the present invention includes an effective ingredient in the micro needle, so that the effective ingredient in the micro needle can be eluted after the micro needle is inserted into the skin, and the effective ingredient can be delivered deep into the skin.
More preferably, according to one embodiment of the present invention, the microneedle may contain the active ingredient itself in order to increase the delivery power of the active ingredient to the skin dermis, but it is preferable that the micro- Lipid complex particles, and the like.
As described above, the carrier contains the active ingredient, and it is preferable that the carrier is present in the soluble polymer so that partial diffusion and loss of the active ingredient can be prevented.
In addition, the delivery agent can deliver the effective ingredient deep into the skin where the effect of the contained active ingredient can be expressed, so that the cosmetic effect can be effectively expressed on the skin.
The microparticles are particles having a size of 1 mm or less, and the matrix is a spherical particle forming a homogeneous sphere. For example, the microparticles may be spherical particles having a uniform density, but the present invention is not limited thereto .
The microencapsulated microcapsule is a spherical microcapsule containing a core surrounded by an active ingredient. For example, the microcapsule may have an active ingredient in its core and a soluble polymer in the form of a shell enclosing the active ingredient. However, It is not.
The charge conjugate particles are complexes formed by physically bonding molecules having different electric charges. As a non-limiting example, composite particles in which anionic polymer and cationic polymer are physically bonded through different charges, anionically charged polyethylene Water-dispersible composite particles through charge bonding between glycol and cation-charged chitosan, water-dispersible composite particles through charge bonding between anionic-charged polyethylene glycol and cation-charged proteins, cation-charged polyethyleneimines and anions A water-dispersible composite particle through charge bonding with a charged protein, and a water-dispersible composite particle through charge bonding between a cation-charged polyethyleneimine and an anion-charged alginate, and the like, Limited to It is not.
The lipid composite particle is a composite in which lipid-based molecules and non-lipid-based molecules are formed through physical or chemical bonding, and examples thereof include, but not limited to, a complex formed by physically mixing dioleolphosphatidyl ethanolamine (DOPE) and hyaluronic acid, A complex formed by chemically bonding ceramide and water-soluble protein to each other through ester bond, and a complex formed by chemically bonding dotap and water-soluble protein to each other through amide bond, and the like. But is not limited thereto.
According to one embodiment of the present invention, the active ingredient may be contained in the soluble polymer in various forms such as a core-shell type, a multi-shell type, . In addition, the carrier may have various shapes such as a spherical shape or a polygonal shape, but is not limited thereto.
In addition, according to one embodiment, the average size of the carrier may be 0.01 to 300 탆. Preferably 0.1 to 100 탆, but is not limited thereto. When an average size of the above range is satisfied, it is preferable because it can contain sufficient active ingredients.
According to one aspect of the present invention, the active ingredient may be, for example, an antiwrinkle agent, a slimming agent, a whitening agent, an antiacne agent, a moisturizer, an antiseborrhoeic agent, an antiaging agent, a keratolytic agent, an antibacterial gent, an antifungal gent, and the like.
The active ingredient may include a functional cosmetic preparation starting material or an inhomogeneous raw material compound. Specific examples of the functional cosmetic preparation include retinol, retinyl palmitate, adenosine, polyethoxylated retinamide, mulberry extract, arbutin, ethyl ascorbyl ether, useful licorice extract, ascorbyl glucoside, magnesium ascorbyl phosphate , Niacinamide, alpha-bisabolol and ascorbyl tetraisopalmitate, and the like. The non-native raw materials include ginseng extract, red ginseng extract, wild ginseng culture extract or fermented product thereof, norulucorp extract, rice bran or its extract, brown rice or its extract, green tea extract, Compound K, catechin, Icariside B2, Icarside B6 and isoflavone, and the like.
In addition, the active ingredient may be any one selected from organic germanium, alkylene glycols, glycerin derivatives, vitamins, plant extracts and derivatives thereof, or a mixture thereof, but is not limited thereto.
The microneedle of the present invention may be included in a conventional cosmetic composition in addition to the active ingredient, and may further include a cosmetic ingredient list registered in the Korean Food and Drug Administration and an ingredient listed in ICID (International Cosmetic Ingredient). The component may be uniformly distributed in the entire nonwoven fabric sheet or the elastic body, and may further include any one or a mixture of two or more selected from the group consisting of an increasing agent, a pH adjusting agent, an emulsifying agent, It is not.
The incrementing agent may include carbomer, acrylate, ammonium acryloyldimethyltaurate-vinylpyrrolidone copolymer, acrylate-C 10 -C 30 alkyl acrylate crosspolymer, xanthan gum and cellulose gum. Any one or two selected from known inorganic or powdered powders such as loess, bentonite, tourmaline, elvan, calcium carbonate, rice bran, wheat, wheat, buckwheat, brown rice, soybean, red bean, mung bean and corn powder The above mixture may be used, but is not limited thereto.
Examples of the pH adjuster include organic acids such as citric acid, succinic acid, tartaric acid, lactic acid, malic acid, fumaric acid, maleic acid and glycolic acid; inorganic acids such as hydrochloric acid, sulfuric acid, phosphoric acid, nitric acid, etc .; sodium, potassium or ammonium salts, And arginine, and the like, or a mixture of two or more thereof. In addition, any one or a mixture of two or more selected from triethanolamine, sodium chloride, sodium hydroxide and potassium hydroxide may be used, but the present invention is not limited thereto.
The emulsifier is not limited as long as it is a raw material generally used in the art, and may be selected from cationic surfactants, anionic surfactants, amphoteric surfactants and nonionic surfactants, but is not limited thereto.
The coloring matters and the flavoring agents may be, but are not limited to, the ingredients commonly used in cosmetic compositions.
According to an aspect of the present invention, the microneedle portion may include a porous base and a plurality of soluble micro-needles formed on the porous base. When the porous base portion for supporting the micro needle is included as described above, the pressure applied through the elastic portion to the micro needle portion can be uniformly dispersed in the micro needle.
The porous base may be a substrate that supports according to an embodiment, and the porous base may be provided with mechanical strength to the microneedle portion, and may be rigid or flexible in itself. If necessary, another second substrate may be further provided. The porous base may further have a through-hole, and further effective ingredient delivery may be made from the opposite side of the micro needle through the through-hole toward the skin.
The porous base may be a planar body having a predetermined thickness, and may be a resin film, a resin sheet, or a fibrous sheet of a woven or nonwoven structure. The resin may be the same soluble polymer as the microneedles or a different polymer. In the case of different polymers, it may preferably include any one selected from polyolefin, polyester, polyamide, polyurethane, polyimide, and polyvinyl chloride, or copolymers thereof. More specifically, any one or two selected from polyethylene, polypropylene, polyvinyl chloride, polyethylene terephthalate (PET), polybutylene terephthalate (PBT), polyamide, polyurethane, polyimide, polyvinyl chloride, Or mixtures thereof. The fiber sheet may also be made of the above-mentioned resin.
The porous base portion is not particularly limited, but it is suitable for the purpose of the present invention to have a porosity of 1,000 to 20,000 g / m < 2 > 24 hr, and more preferably 6,000 to 15,000 g / m &
The porous base may have pores having an average pore size of 0.01 to 500 탆, and preferably pores having a pore size of 1 to 300 탆 so as to facilitate water supply or passage of the active ingredient. But is not limited thereto.
According to one aspect of the present invention, the height of the soluble micro needle may be 50 to 1,500 mu m, and the thickness of the porous base portion of the micro needle may be 10 to 1,000 mu m. Preferably, the solubility microneedle height may be between 50 and 1,000 microns, and the thickness of the porous base of the microneedles may be between 10 and 500 microns. When manufactured as described above, the skin is easily inserted, the pressure applied by the elastic part can be uniformly transmitted, and flexibility can be maintained.
According to an aspect of the present invention, the elastic portion may be coupled to the micro needle portion. The microneedle elastic structure coupled as described above is deformed to conform to the curved face, and the pressure is transmitted to the entire face, so that the effective ingredient can be uniformly delivered. Pressure can be easily applied to the face by applying strong pressure with the hand, There is an advantage that the effective component can be transmitted deeply.
To this end, the elastic portion may be composed of an elastic body or an elastomer according to an embodiment. Preferably, the elastomer or elastomer may refer to the intrinsic material itself having elastomeric properties and may include a foam having elastomeric properties. Specific examples of the elastomer or elastomer include elastomers such as butadiene rubber, styrene-butadiene rubber, styrene-butadiene-styrene rubber, acrylonitrile rubber, acrylonitrile-butadiene rubber, acrylic rubber, ethylene- , Styrene-propylene rubber, silicone rubber, polyurethane rubber and hybrid silicone rubber, and the like.
The use of the elastic body or the elastomer of the present invention is a constitution that can solve the difficulty that the effective component is transmitted to the deep part of the skin to a small extent due to a weak force transmitted to the pressure applied to the face. As a result, the micro needle elastic structure of the present invention is deformed to conform to the curved face when the micro needle elastic structure is combined with the elastic part including the elastic body or the elastomer and the micro needle part, so that the pressure is uniformly distributed throughout the face, By applying strong pressure by hand, pressure can easily be delivered to the face, and effective ingredients can be delivered deep into the skin.
In the present invention, it is more preferable that the elastomer or elastomer has a compression set durability of 0.1 to 70% after compression measured at 70 DEG C for 168 hours in accordance with ASTM D395. Preferably, the compression set length may be 0.1 to 50%. When the pressure is transferred to the skin, the elastomer or elastomer having the compression set stiffness within the above range can sufficiently transmit the force to pass the micro needle through the skin with excellent elastic recovery rate, and the effective ingredient can be delivered deep into the skin. At the same time, since the pressure to be inserted into the skin is applied and the micro needle penetrates, the elastic part immediately has a recovery ability, shortening the time required for the micro needle to stay in the skin, and minimizing the damage, irritation and foreign body feeling of the skin.
Also, according to one embodiment of the present invention, the elastomer or elastomer may have a Shore hardness of 00 (shore 00) measured according to ASTM D2240 of 20 to 98. [ Preferably from 25 to 80, and more preferably from 30 to 70. [ When the shore hardness is in the above range, irritation of the skin is prevented, and even effective skin such as a curved face or the like can be effectively delivered with a uniform pressure.
According to an embodiment of the present invention, there is no limitation on the shape of the elastic portion. For example, the shape of the elastic portion may be variously changed without limitation to a shape such as a sphere, a polygon, and a rectangular parallelepiped. In addition, when a string, a handle, or the like is connected to the elastic portion of the micro needle elastic structure of the present invention, it is possible to improve the fixing force of the micro needle elastic structure and the hand.
According to an aspect of the present invention, an adhesive layer for adhering the micro needle portion and the elastic portion may be further included. The adhesive layer may be formed of at least one selected from the group consisting of urea, melamine, phenol, unsaturated polyester, epoxy, resorcinol, vinyl acetate, polyvinyl alcohol, vinyl chloride, But are not limited to, those selected from the group consisting of amide, polyethylene, butadiene rubber, nitrile rubber, butyl rubber, silicone rubber, chloroprene rubber, vinyl, phenol-crooprene, epoxidized nitrile rubber, glue, latex, And may be made of one or more adhesives.
The adhesive of the present invention may be formed by applying an adhesive to the surface of the micro needle portion and the elastic portion to which the elastic portion is coupled. May be applied in whole or in part. Preferably, it can be applied in the form of a pin. This is more economical than that applied on the entire surface, and porosity and moisture permeability can be ensured by the whole adhesion.
According to an aspect of the present invention, a moisture supply unit may further be provided between the micro needle portion and the elastic portion. The water supply part may form a hollow space between the microneedle part and the elastic part by adjusting the shape of the elastic part and position the moisture supply part in the hollow space. As described above, since the moisture supply portion is provided in the hollow space of the elastic portion, moisture can be supplied to the micro needle portion through the porous base portion by the pressure applied to the elastic portion. The water supply part may be composed of water or an aqueous solution containing an active ingredient. Specifically, when pressure is applied to the elastic portion, moisture inside the water supply portion leaks and an effective ingredient in the dissolved micro needle can be absorbed or impregnated into the skin.
Accordingly, it is more preferable that the microneedles inserted into the skin dissolve and the active ingredient can be delivered into the skin.
Hereinafter, the micro needle elastic structure according to the present invention will be described in more detail with reference to examples. It should be understood, however, that the invention is not limited to the disclosed embodiments, but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the invention.
Unless otherwise defined, all technical and scientific terms have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
According to an embodiment of the present invention, when the micro needle elastic structure includes a soluble micro needle, the micro needle elastic structure may be formed of an aqueous solution containing water or an active ingredient applied to the skin, or a soluble micro needle inserted into the skin by a water supply part inside the elastic structure And the effective ingredient is dissolved and transferred to the dermis, so that a more excellent cosmetic effect can be exhibited. In addition, since the microneedle portion and the elastic portion are coupled to each other, the pressure applied to the elastic portion can uniformly transfer the effective ingredient to the deep portion of the skin, and even if the elastic portion is used for a curved face, So that the effective component can be uniformly distributed throughout the curved face.
Furthermore, according to one aspect of the present invention, the micro needle elastic structure is made of an elastic material containing an elastomer or elastomer having a compression set ratio of 0.1 to 70% after compression at 70 DEG C for 168 hours according to ASTM D395 , The active ingredient can be delivered deep into the skin, with a good elastic recovery rate capable of delivering sufficient force to penetrate the micro needle into the skin. In addition, it can return to the skin without staying in the skin for a long time after passing through the micro-knittle with excellent elastic recovery force, thereby preventing damages and irritation to the skin and providing excellent feeling with less foreign body feeling.
In addition, when the active ingredient is delivered in the form of microcapsules in the micro needle, it can be delivered to the skin without loss, and the effective ingredient provided in the skin can be gradually released in the skin, thereby improving the sustainability of the effective ingredient effect.
In addition, when the moisture supply portion is provided between the micro needle portion and the elastic portion, the pressure of the elastic portion is transmitted to dissolve the micro needle inserted into the skin more easily, and when the pressure of the elastic portion is directly received, The calendar is further improved.
Further, when the porous base portion is formed on the micro needle portion, it is more preferable to insert the skin of the soluble micro needle with a superior pressure transmission.
Accordingly, the micro needle elastic structure of the present invention can provide a micro needle elastic structure capable of uniformly delivering an active ingredient to a curved skin, particularly a face, and easily transferring pressure, and delivering an effective ingredient deep into the skin.
In addition, when the micro needle portion attached on the elastic portion is constituted to be soluble, the micro needle is inserted into the skin and dissolved by the water or the aqueous solution containing the active ingredient applied to the skin to release the effective ingredient contained in the micro needle portion It can be easily delivered deep into the skin.
Accordingly, the micro needle elastic structure according to the present invention can exhibit a uniform and high cosmetic effect expression rate on the entire face, and thus can achieve an excellent effect including any effective ingredient capable of obtaining a cosmetic effect. In addition, it showed excellent sensitivity in sensory evaluation because it has excellent skin feel with little skin irritation and foreign body sensation.
As described above, the present invention has been described with respect to specific items and a limited micro needle elastic structure. However, it should be understood that the present invention is not limited to the above- Various modifications and variations are possible.
Therefore, the spirit of the present invention should not be limited to the following claims, and all of the equivalents or equivalents of the claims are within the scope of the present invention.
1: Micro needle 2: Elastic part
3: adhesive layer 4: porous base 5: water supply part
Claims (10)
A micro needle portion formed on the porous base portion and having a plurality of soluble micro-needles dissolved therein by water or an aqueous solution containing an active ingredient;
A resilient portion associated with the porous base portion and having a compression set rheology of 0.1 to 70% as measured according to ASTM D395,
Wherein the microneedle portion contains an active ingredient.
Wherein the soluble micro needle is any one or a mixture of two or more selected from an acrylic polymer, a vinyl alcohol polymer, a vinyl pyrrolidone polymer, a cellulose derivative, an alkylene oxide polymer, and a polysaccharide.
The elastic portion may be at least one selected from the group consisting of butadiene rubber, styrene-butadiene rubber, styrene-butadiene-styrene rubber, acrylonitrile rubber, acrylonitrile- butadiene rubber, acrylic rubber, ethylene- A silicone rubber, a silicone rubber, a polyurethane rubber, and a hybrid silicone rubber.
And an adhesive layer for adhering the micro needle portion and the elastic portion.
And a moisture supply portion between the micro needle portion and the elastic portion.
When pressure is applied to the elastic part, moisture in the water supply part leaks and an effective ingredient in the dissolved micro needle is absorbed or impregnated in the skin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/KR2018/006544 WO2018226069A1 (en) | 2017-06-09 | 2018-06-08 | Micro needle elastic structure |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020170072332 | 2017-06-09 | ||
| KR20170072332 | 2017-06-09 |
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| KR20180134744A KR20180134744A (en) | 2018-12-19 |
| KR101976431B1 true KR101976431B1 (en) | 2019-05-10 |
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| KR1020180045526A KR101976431B1 (en) | 2017-06-09 | 2018-04-19 | Micro needle elastic structure |
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| KR20210029581A (en) * | 2019-09-06 | 2021-03-16 | 연세대학교 산학협력단 | Micro-needle patch and micro-needle system |
| KR20220039907A (en) * | 2020-09-21 | 2022-03-30 | 이승욱 | Micro needle sheet cosmetic tool comprising perforous pad |
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| KR200494105Y1 (en) * | 2019-04-26 | 2021-08-03 | (주)디에스테크 | Micro needle roller device |
| CN111588689B (en) * | 2020-06-20 | 2023-08-11 | 温州医科大学 | Cornea minimally invasive soluble microneedle patch and preparation method and application thereof |
| CN113876102A (en) * | 2020-12-22 | 2022-01-04 | 中国人民解放军海军军医大学 | Microneedle-enhanced puff |
| KR102381967B1 (en) * | 2021-05-24 | 2022-04-04 | 주식회사 더마젝 | Multilayer microneedle array and manufacturing method thereof |
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| KR20180134744A (en) | 2018-12-19 |
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