WO2018198569A1 - Biocapteur - Google Patents

Biocapteur Download PDF

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Publication number
WO2018198569A1
WO2018198569A1 PCT/JP2018/010199 JP2018010199W WO2018198569A1 WO 2018198569 A1 WO2018198569 A1 WO 2018198569A1 JP 2018010199 W JP2018010199 W JP 2018010199W WO 2018198569 A1 WO2018198569 A1 WO 2018198569A1
Authority
WO
WIPO (PCT)
Prior art keywords
pressure
sensitive adhesive
base material
layer
probe
Prior art date
Application number
PCT/JP2018/010199
Other languages
English (en)
Japanese (ja)
Inventor
良真 吉岡
豊田　英志
敬史 竹村
森　重恭
Original Assignee
日東電工株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2018040596A external-priority patent/JP7033469B2/ja
Application filed by 日東電工株式会社 filed Critical 日東電工株式会社
Priority to CN201880027341.4A priority Critical patent/CN110545718B/zh
Priority to US16/608,975 priority patent/US20200187859A1/en
Priority to EP18792289.3A priority patent/EP3616607A4/fr
Publication of WO2018198569A1 publication Critical patent/WO2018198569A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A61B5/6832—Means for maintaining contact with the body using adhesives
    • A61B5/6833—Adhesive patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A61B5/332—Portable devices specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0219—Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/022—Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A61B5/02438—Detecting, measuring or recording pulse rate or heart rate with portable devices, e.g. worn by the patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1477—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means non-invasive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/251—Means for maintaining electrode contact with the body
    • A61B5/257—Means for maintaining electrode contact with the body using adhesive means, e.g. adhesive pads or tapes
    • A61B5/259—Means for maintaining electrode contact with the body using adhesive means, e.g. adhesive pads or tapes using conductive adhesive means, e.g. gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/296—Bioelectric electrodes therefor specially adapted for particular uses for electromyography [EMG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4261—Evaluating exocrine secretion production
    • A61B5/4266—Evaluating exocrine secretion production sweat secretion

Definitions

  • the present invention relates to a biosensor.
  • an adhesive biosensor that is attached to the surface of a living body and senses the living body is known.
  • a biosensor for example, a physiological monitoring device having a rigid housing that accommodates a printed circuit board assembly and a flexible wing that extends from the housing has been proposed (for example, a patent). Reference 1).
  • the wing is a flexible body including an electrode, an upper substrate layer and a bottom substrate layer sandwiching the electrode, and an adhesive layer positioned below the bottom substrate layer.
  • the thicknesses of the upper substrate layer and the bottom substrate layer are adjusted so that the total thickness of the flexible body is between 0.1 mm and 1.0 mm.
  • the thickness of the device housing portion is thick and the structure is not in close contact with the skin surface. Therefore, the body movement during continuous wearing tends to cause a catch or the like, and this causes the wing to easily peel off, resulting in an increase in motion artifacts.
  • the present invention provides a biosensor capable of reducing the feeling of wearing with respect to a living body.
  • the present invention (1) includes a pressure-sensitive adhesive layer for application to the surface of a living body, an upper surface of the pressure-sensitive adhesive layer, a stretchable base material layer, and a lower surface of the pressure-sensitive adhesive layer. And the electronic component mounted on the base material layer so as to be connected to the probe, and the total thickness of the pressure-sensitive adhesive layer and the base material layer is 1 ⁇ m or more and less than 100 ⁇ m, Includes biosensors.
  • the present invention (2) includes the biosensor according to (1), wherein the pressure-sensitive adhesive layer has a thickness of 10 ⁇ m or more and 95 ⁇ m or less.
  • This invention (3) contains the biosensor as described in (1) or (2) whose thickness of the said electronic component is 1 micrometer or more and 1000 micrometers or less.
  • the present invention (4) includes the biosensor according to any one of (1) to (3), wherein a plane area of the electronic component is 0.001 mm 2 or more and 10 mm 2 or less.
  • the total thickness of the pressure-sensitive adhesive layer and the base material layer is as thin as 1 ⁇ m or more and less than 100 ⁇ m, even when the biosensor is attached to the surface of the living body, the feeling of wearing on the living body is sufficiently reduced. can do.
  • the manufacturing cost per biosensor can be reduced, and thus the biosensor can be disposable.
  • FIG. 1 is a plan view of an adhesive biosensor that is an embodiment of the biosensor of the present invention.
  • 2A and 2B are cross-sectional views of the adhesive biosensor shown in FIG. 1.
  • FIG. 2A is a cross-sectional view taken along the line AA
  • FIG. 2B is a cross-sectional view taken along the line BB.
  • 3A to 3D are manufacturing process diagrams of the pasted biosensor shown in FIG. 2A.
  • FIG. 3A is a process for preparing a base material layer and a wiring layer
  • FIG. 3B is a pressure sensitive adhesive layer and a base material layer.
  • the bonding step, FIG. 3C shows the step of forming the opening and preparing the probe member, FIG.
  • FIG. 3D shows the step of fitting the probe member into the opening, and the step of forming the connecting portion.
  • FIG. 4 is a perspective view of the probe-containing sheet as viewed from below, and shows a perspective view in which a part of the second release sheet is cut out.
  • FIG. 5 is a perspective view for explaining a manufacturing process of the probe member.
  • An upper side view is a perspective view seen from the lower side.
  • a lower side view shows a perspective view seen from the upper side.
  • 6A to 6C are exploded perspective views of the probe member.
  • FIG. 6A shows the probe member
  • FIG. 6B shows the connection portion
  • FIG. 6C shows the opening at one end in the longitudinal direction of the adhesive biosensor.
  • FIG. 7A and 7B are cross-sectional views of a patch-type biosensor according to a modification of one embodiment.
  • FIG. 7A shows an embodiment in which the upper part of the probe is embedded in a pressure-sensitive adhesive layer
  • FIG. The mode which is not embedded in a pressure bonding layer but protrudes from a pressure sensitive bonding layer is shown.
  • 8A to 8G are cross-sectional views of a patch-type biosensor according to a modification of one embodiment.
  • FIG. 8A shows an embodiment in which the lower part of the wiring layer is embedded in the base material layer
  • FIG. 8B shows the wiring layer. A mode in which the wiring layer is not embedded in the base material layer and protrudes upward from the base material layer, FIG.
  • FIG. 8C is a mode in which the wiring layer is not exposed from the base material layer and the wiring layer is embedded in the base material layer, and FIG. Is embedded in the base material layer so that it is exposed from the lower surface of the base material
  • FIG. 8E is an embodiment in which the wiring layer is embedded in both the pressure-sensitive adhesive layer and the base material layer
  • FIG. 8G shows an embodiment in which the wiring layer is not exposed from the pressure-sensitive adhesive layer but is embedded in the pressure-sensitive adhesive layer so as to be exposed from the adhesive upper surface.
  • FIG. 9 is an exploded perspective view of a patch-type biosensor (a connection portion is a substantially half ring shape in plan view) according to a modification of the embodiment.
  • FIG. 9 is an exploded perspective view of a patch-type biosensor (a connection portion is a substantially half ring shape in plan view) according to a modification of the embodiment.
  • FIG. 9 is an exploded perspective view of a patch-type biosensor (a connection portion is a substantially half ring shape in plan view)
  • FIG. 10 is an exploded view of a patch-type biosensor (an embodiment in which the connection portion has an upper end portion having a substantially half ring shape in plan view and a plurality of first filaments extending downward therefrom) according to a modification of the embodiment.
  • a perspective view is shown.
  • 11A to 11C are perspective views of a probe member of a patch type biosensor according to a modification of one embodiment, in which FIG. 11A is an aspect in which the connection portion has a slit, and FIG. 11B is a second wire in the connection portion.
  • FIG. 11C shows a mode in which the connection part has a net part.
  • FIG. 12 shows a cross-sectional view of a paste-type biosensor (probe has a substantially plate shape) according to a modification of the embodiment.
  • FIG. 13 is a cross-sectional view of a paste-type biosensor (probe is a solid columnar shape) according to a modification of the embodiment.
  • FIG. 14 shows a plan view of a patch-type biosensor (a connecting portion is substantially a rod (needle) column shape) according to a modification of the embodiment.
  • FIG. 15 is a cross-sectional view taken along line AA of the pasted biosensor shown in FIG.
  • FIG. 16 is a cross-sectional view of a patch-type biosensor (a connection portion is a substantially bar (needle) shape and a probe is a substantially plate shape) according to a modification of the embodiment.
  • 17A and 17B are further modified examples of the adhesive biosensor shown in FIG. 15.
  • FIG. 15 is a cross-sectional view of a paste-type biosensor (probe is a solid columnar shape) according to a modification of the embodiment.
  • FIG. 14 shows a plan view of a patch-type biosensor (a connecting portion is substantially
  • FIG. 17A shows an embodiment in which a conductive pressure-sensitive adhesive layer is provided on the lower surface of the probe
  • FIG. 17B shows a pressure-sensitive strong adhesive layer of the probe.
  • the aspect provided in a hole is shown.
  • FIG. 18 is a plan view of a patch-type biosensor (an embodiment in which a probe and a connection unit are integrated) according to a modification of the embodiment.
  • FIG. 19 is a cross-sectional view taken along the line AA of the adhesive biosensor shown in FIG.
  • FIG. 20 shows a cross-sectional view of a modification in which the probe is larger than the connecting portion.
  • FIG. 21 shows an enlarged perspective view of the probe and the connecting portion shown in FIG.
  • FIG. 22A and 22B are cross-sectional views of a patch-type biosensor according to a modification of one embodiment.
  • FIG. 22A is a mode in which a protective layer including a protective substrate and a second pressure-sensitive adhesive layer is provided, and FIG. The aspect in which the protective layer which consists only of a protective base material is provided is shown.
  • the left-right direction on the paper is the longitudinal direction (first direction) of the paste-type biosensor 30.
  • the right side of the drawing is one side in the longitudinal direction (one side in the first direction), and the left side of the drawing is the other side in the longitudinal direction (the other side in the first direction).
  • the up and down direction on the paper surface is the short direction (the direction orthogonal to the longitudinal direction, the width direction, and the second direction orthogonal to the first direction) of the adhesive biosensor 30.
  • the upper side of the drawing is one side in the short direction (one side in the width direction, one side in the second direction), and the lower side of the drawing is the other side in the short direction (the other side in the width direction, the other side in the second direction).
  • the paper thickness direction is the vertical direction of the biopsy sensor 30 (thickness direction, third direction orthogonal to the first direction and the second direction).
  • the front side of the paper is the upper side (one side in the thickness direction, the one side in the third direction), and the back side of the paper is the lower side (the other side in the thickness direction, the other side in the third direction).
  • the direction conforms to the direction arrow described in each drawing.
  • the adhesive biosensor 30 has a substantially flat plate shape extending in the longitudinal direction.
  • the adhesive biosensor 30 includes a pressure-sensitive adhesive layer 2, a base material layer 3 disposed on an adhesive upper surface as an example of an upper surface of the pressure-sensitive adhesive layer 2, a wiring layer 4 disposed on the base material layer 3,
  • the probe 5 disposed on the adhesive lower surface 9 as an example of the lower surface of the pressure-sensitive adhesive layer 2, the wiring layer 4 and the connection portion 6 that electrically connects the probe 5, and the electrons that are electrically connected to the wiring layer 4 And a component 31.
  • the pressure-sensitive adhesive layer 2 forms the lower surface of the adhesive biosensor 30.
  • the pressure-sensitive adhesive layer 2 is a layer that provides pressure-sensitive adhesiveness to the lower surface of the adhesive biosensor 30 in order to attach the lower surface of the adhesive biosensor 30 to the surface of the living body (such as the skin 33 indicated by a virtual line). It is.
  • the pressure sensitive adhesive layer 2 forms the outer shape of the adhesive biosensor 30.
  • the pressure sensitive adhesive layer 2 has a flat plate shape extending in the longitudinal direction. Specifically, for example, the pressure-sensitive adhesive layer 2 has a strip shape extending in the longitudinal direction, and has a shape in which the center portion in the longitudinal direction swells toward both outer sides in the lateral direction. Further, in the pressure-sensitive adhesive layer 2, both ends in the short direction of the central portion in the longitudinal direction are located on both outer sides in the short direction with respect to both ends in the short direction other than the central portion in the longitudinal direction.
  • the pressure-sensitive adhesive layer 2 has an adhesive upper surface 8 and an adhesive lower surface 9.
  • the adhesive upper surface 8 is a flat surface.
  • the adhesive lower surface 9 is disposed to face the lower side of the adhesive upper surface 8 with a gap.
  • the pressure-sensitive adhesive layer 2 has two adhesive openings 11 at both ends in the longitudinal direction.
  • Each of the two bonding openings 11 has a substantially ring shape in plan view.
  • the adhesive opening 11 penetrates the thickness direction of the pressure-sensitive adhesive layer 2.
  • the bonding opening 11 is filled with the connecting portion 6.
  • the adhesive lower surface 9 inside the adhesive opening 11 has an adhesive groove 10 corresponding to the probe 5 (described later).
  • the adhesive groove 10 is opened downward.
  • the material of the pressure-sensitive adhesive layer 2 is not particularly limited as long as it is a material having pressure-sensitive adhesiveness, and examples thereof include a material having biocompatibility.
  • examples of such materials include acrylic pressure sensitive adhesives and silicone pressure sensitive adhesives.
  • an acrylic pressure sensitive adhesive is used.
  • the acrylic pressure-sensitive adhesive include acrylic polymers described in JP-A-2003-325441.
  • the stratum corneum peel area ratio is, for example, 50% or less, preferably 30% or less, more preferably 15% or less, and, for example, 0% or more. It is. If the stratum corneum peeling area ratio is equal to or less than the above upper limit, even if the pressure-sensitive adhesive layer 2 is adhered to a living body, the load on the living body can be suppressed. That is, the material of the pressure-sensitive adhesive layer 2 can have excellent biocompatibility.
  • the stratum corneum peeling test is measured by the method described in JP-A-2004-83425.
  • the moisture permeability of the pressure-sensitive adhesive layer 2 is, for example, 300 (g / m 2 / day) or more, preferably 600 (g / m 2 / day) or more, and more preferably 1000 (g / m 2 / day). That's it.
  • the moisture permeability of the pressure-sensitive adhesive layer 2 is equal to or higher than the lower limit described above, even if the pressure-sensitive adhesive layer 2 is attached to a living body, the load on the living body can be suppressed. That is, the material of the pressure-sensitive adhesive layer 2 can have excellent biocompatibility.
  • the stratum corneum peel area ratio in the stratum corneum peel test satisfies at least one of the requirements of 50% or less and (2) moisture permeability of 300 (g / m 2 / day) or more, preferably (1) and ( If both requirements of 2) are satisfied, the material of the pressure-sensitive adhesive layer 2 has biocompatibility.
  • the thickness T2 of the pressure-sensitive adhesive layer 2 is, for example, 10 ⁇ m or more, preferably 20 ⁇ m or more, and for example, 95 ⁇ m or less, as the distance between the adhesive upper surface 8 and the adhesive lower surface 9 in the region other than the adhesive groove 10. Is 70 ⁇ m or less, more preferably 50 ⁇ m or less.
  • the total thickness T1 (described later) of the pressure-sensitive adhesive layer 2 and the base material layer 3 can be set to be lower than the upper limit.
  • the thickness of the biometric sensor 30 can be reduced, and in particular, the area other than the electronic component 31 in the adhesive biosensor 30 can be reduced.
  • the dimensions of the pressure-sensitive adhesive layer 2 in plan view are appropriately set according to the skin 33 (described later) to which the pasting-type biosensor 30 is pasted.
  • the longitudinal length L1 of the pressure-sensitive adhesive layer 2 is, for example, 30 mm or more, preferably 50 mm or more, and, for example, 1000 mm or less, preferably 200 mm or less.
  • the transverse length L2 of the pressure-sensitive adhesive layer 2 is, for example, 5 mm or more, preferably 10 mm or more, and for example, 300 mm or less, preferably 100 mm or less.
  • Plane area of the pressure-sensitive adhesive layer 2 is, for example, 150 mm 2 or more, preferably, 500 mm 2 or more, more preferably at 900 mm 2 or more, and is, for example, 300000Mm 2 or less, preferably 20000 mm 2 or less, more preferably Is 10000 mm 2 or less.
  • the base material layer 3 forms the upper surface of the paste-type biosensor 30 together with an electronic component 31 described later.
  • the base material layer 3 forms the outer shape of the adhesive biosensor 30 together with the pressure-sensitive adhesive layer 2.
  • the planar view shape of the base material layer 3 is the same as the planar view shape of the pressure-sensitive adhesive layer 2.
  • the base material layer 3 is disposed on the entire upper surface of the pressure-sensitive adhesive layer 2 (however, excluding the region where the connection portion 6 is provided).
  • the base material layer 3 is a support layer that supports the pressure-sensitive adhesive layer 2.
  • the base material layer 3 has a flat plate shape extending in the longitudinal direction.
  • the substrate layer 3 has a substrate lower surface 12 and a substrate upper surface 13.
  • the base material lower surface 12 is a flat surface.
  • the base material lower surface 12 is in contact (pressure-sensitive adhesion) with the adhesive upper surface 8 of the pressure-sensitive adhesive layer 2.
  • the base material upper surface 13 is disposed to face the upper surface of the base material lower surface 12 with a gap.
  • the base material upper surface 13 has a base material groove 14 corresponding to the wiring layer 4.
  • the substrate groove 14 has the same pattern shape as the wiring layer 4 in plan view.
  • the base material groove 14 is opened upward.
  • the base material layer 3 has a base material opening 15 corresponding to the adhesive opening 11.
  • the base material opening 15 communicates with the bonding opening 11 in the thickness direction.
  • the base material opening 15 has a substantially ring shape in plan view having the same shape and the same dimensions as the bonding opening 11.
  • the material of the base material layer 3 has stretchability, for example. Moreover, the material of the base material layer 3 has an insulating layer, for example.
  • An example of such a material is a resin.
  • the resin include thermoplastic resins such as polyurethane resins, silicone resins, acrylic resins, polystyrene resins, vinyl chloride resins, and polyester resins.
  • a polyurethane-based resin is preferably used as a material for the base material layer 3.
  • a polyurethane-based resin is preferably used from the viewpoint of securing more excellent stretchability.
  • the breaking elongation of the base material layer 3 is, for example, 100% or more, preferably 200% or more, more preferably 300% or more, and for example, 2000% or less. If the breaking elongation is not less than the above lower limit, the material of the base material layer 3 can have excellent stretchability.
  • the elongation at break is measured according to JIS K 7127 (1999) with a tensile rate of 5 mm / min and a test piece type 2.
  • the tensile strength at 20 ° C. of the base material layer 3 is, for example, 0.1 N / 20 mm or more, preferably 1 N / 20 mm or more. For example, it is 20 N / 20 mm or less.
  • the tensile strength is measured based on JIS K 71271999.
  • the tensile storage elastic modulus E ′ at 20 ° C. of the base material layer 3 is, for example, 2,000 MPa or less, preferably 1,000 MPa or less, more preferably 100 MPa or less, still more preferably 50 MPa or less, particularly preferably. , 20 MPa or less, and for example, 0.1 MPa or more. If the tensile storage elastic modulus E ′ of the base material layer 3 is not more than the above upper limit, the material of the base material layer 3 can have excellent stretchability.
  • the tensile storage elastic modulus E ′ at 20 ° C. of the base material layer 3 is obtained by measuring the dynamic viscoelasticity of the base material layer 3 under the conditions of a frequency of 1 Hz and a temperature increase rate of 10 ° C./min.
  • Elongation at break 100% or more
  • Tensile strength is 20 N / 20 mm or less
  • Tensile storage elastic modulus E ′ is at least one requirement of 2,000 MPa or less, preferably 2 or more If the above requirements, more preferably all three requirements are satisfied, the material of the base material layer 3 has stretchability.
  • the thickness T3 of the base material layer 3 is, for example, 1 ⁇ m or more, preferably 5 ⁇ m or more, and, for example, 95 ⁇ m or less as the distance between the base material lower surface 12 and the base material upper surface 13 in the region other than the base material groove 14.
  • the thickness is preferably 50 ⁇ m or less, more preferably 10 ⁇ m or less.
  • the total thickness T1 of the pressure-sensitive adhesive layer 2 and the base material layer 3, that is, the total T1 (T2 + T3) of the thickness T2 of the pressure-sensitive adhesive layer 2 and the thickness T3 of the base material layer 3 is 1 ⁇ m or more, preferably It is 10 ⁇ m or more, and less than 100 ⁇ m, preferably 70 ⁇ m or less, more preferably 50 ⁇ m or less.
  • the total thickness T1 of the pressure-sensitive adhesive layer 2 and the base material layer 3 is the distance between the adhesive lower surface 9 of the pressure-sensitive adhesive layer 2 and the base material upper surface 13 of the base material layer 3, and the wiring layer 4 and The thickness of the probe 5 is not included.
  • the adhesive biosensor 30 can be a disposable type.
  • the handleability of the adhesive biosensor 30 can be improved.
  • the wiring layer 4 is embedded in the base material groove 14. Specifically, the wiring layer 4 is embedded in the upper part of the base material layer 3 so as to be exposed from the base material upper surface 13 of the base material layer 3.
  • the wiring layer 4 has an upper surface and a lower surface that are spaced apart from each other, and a side surface that connects their peripheral edges. All of the lower surface and all of the side surfaces are in contact with the base material layer 3.
  • the upper surface is exposed from the substrate upper surface 13 (excluding the substrate groove 14).
  • the upper surface of the wiring layer 4 forms the upper surface of the adhesive biosensor 30 together with the upper surface 13 of the substrate and the electronic component 31.
  • the wiring layer 4 has a wiring pattern for connecting the connecting portion 6 to an electronic component 31 (described later) and a battery 32 (described later). Specifically, the wiring layer 4 includes a first wiring pattern 41 and a second wiring pattern 42 independently.
  • the first wiring pattern 41 is arranged on one side in the longitudinal direction of the base material layer 3.
  • the first wiring pattern 41 includes a first wiring 16A, and a first terminal 17A and a second terminal 17B continuous thereto.
  • the first wiring pattern 41 has a substantially T shape in plan view. Specifically, the first wiring pattern 41 extends from one end of the base material layer 3 in the longitudinal direction (the connecting portion 6) to the other side in the longitudinal direction, and branches at the center in the longitudinal direction of the base material layer 3. , Extending toward both outer sides in the short direction.
  • Each of the first terminal 17A and the second terminal 17B is disposed at each of both ends of the base layer 3 in the longitudinal direction center.
  • Each of the first terminal 17A and the second terminal 17B has a substantially rectangular shape (land shape) in plan view.
  • Each of the first terminal 17A and the second terminal 17B is continuous with both end portions of the first wiring 16A extending outward in the lateral direction at the center portion in the longitudinal direction of the base material layer 3.
  • the second wiring pattern 42 is provided on the other side in the longitudinal direction of the first wiring pattern 41 with an interval.
  • the second wiring pattern 42 includes a second wiring 16B, and a third terminal 17C and a fourth terminal 17D continuous thereto.
  • the second wiring pattern 42 has a substantially T shape in plan view. Specifically, the second wiring pattern 42 extends from the other end portion in the longitudinal direction of the base material layer 3 (the connection portion 6 located in the longitudinal direction) to one side in the longitudinal direction, and branches at the central portion in the longitudinal direction of the base material layer 3. Extending toward the outside in the lateral direction.
  • Each of the 3rd terminal 17C and the 4th terminal 17D is arranged in each of both ends of the transversal direction in the longitudinal direction central part of base material layer 3.
  • Each of the third terminal 17C and the fourth terminal 17D has a substantially rectangular shape (land shape) in plan view.
  • Each of the third terminal 17C and the fourth terminal 17D is continuous with each of both end portions of the second wiring 16B extending outward in the lateral direction at the center portion in the longitudinal direction of the base material layer 3.
  • Examples of the material of the wiring layer 4 include conductors such as copper, nickel, gold, and alloys thereof.
  • the material of the wiring layer 4 is preferably copper.
  • the thickness T4 of the wiring layer 4 is thinner than the thickness T3 of the base material layer 3, for example.
  • the thickness T4 of the wiring layer 4 is, for example, 0.1 ⁇ m or more, preferably 1 ⁇ m or more, and, for example, 100 ⁇ m or less, preferably 50 ⁇ m or less.
  • the probe 5 is an electrode that senses an electrical signal, temperature, vibration, sweat, metabolite, etc. from a living body when the pressure-sensitive adhesive layer 2 is attached to the skin 33 and in contact with the skin 33.
  • the probe 5 is embedded in the pressure-sensitive adhesive layer 2 so as to be exposed from the adhesive lower surface 9 of the pressure-sensitive adhesive layer 2. That is, the probe 5 is embedded in the adhesive groove 10 in the pressure-sensitive adhesive layer 2 inside the adhesive opening 11.
  • the probe 5 is disposed on the bonding lower surface 9 that forms the bonding groove 10.
  • the probe 5 is embedded in the lower end portion of the pressure-sensitive adhesive layer 2 inside the bonding opening 11.
  • the probe 5 has a net shape, preferably a substantially grid shape (or substantially mesh shape) in plan view. In other words, the probe 5 has holes that are spaced from each other in the surface direction (longitudinal direction and short direction). The hole is filled with the pressure-sensitive adhesive layer 2.
  • the probe 5 has a substantially rectangular shape in a cross-sectional view orthogonal to the direction in which the probe 5 extends.
  • the probe 5 includes a probe lower surface 20, a probe upper surface 21 that is disposed opposite to the probe lower surface 20 with a space therebetween, and a side surface that connects the probe lower surface 20 and the peripheral edge of the probe upper surface 21.
  • the probe lower surface 20 is exposed from the adhesive lower surface 9 (excluding the adhesive groove 10) of the pressure-sensitive adhesive layer 2.
  • the probe lower surface 20 is flush with the adhesive lower surface 9.
  • the probe lower surface 20 forms the lower surface of the adhesive biosensor 30 together with the adhesive lower surface 9.
  • the probe upper surface 21 and side surfaces are covered with the pressure-sensitive adhesive layer 2.
  • the outermost surface of the side surfaces of the probe 5 is the outer surface 22.
  • the outer side surface 22 forms a virtual circle that passes through the outer side surface 22 in plan view.
  • Examples of the material of the probe 5 include the materials exemplified in the wiring layer 4 (specifically, conductors).
  • the external dimensions of the probe 5 are set so that the virtual circle passing through the outer surface 22 overlaps the inner peripheral surface defining the bonding opening 11 in plan view.
  • the thickness T5 of the probe 5 is thinner than the thickness T2 of the pressure-sensitive adhesive layer 2, for example.
  • the thickness T5 of the probe 5 is, for example, 0.1 ⁇ m or more, preferably 1 ⁇ m or more, and for example, 100 ⁇ m or less, preferably 50 ⁇ m or less.
  • connection part 6 is provided corresponding to the base material opening part 15 and the adhesion
  • the connection part 6 penetrates (passes) the base material layer 3 and the pressure-sensitive adhesive layer 2 in the thickness direction (vertical direction), and is filled in the base material opening 15 and the adhesive opening 11.
  • the connecting portion 6 has an endless shape in plan view along the outer surface 22 of the probe 5. Specifically, the connecting portion 6 has a substantially cylindrical shape whose axis extends in the thickness direction (along a virtual circle passing through the outer surface 22).
  • the inner surface of the connecting portion 6 is in contact with the outer surface 22 of the probe 5.
  • the connecting portion 6 is pressure-sensitively bonded to the pressure-sensitive adhesive layer 2 outside the adhesive opening 11 and the pressure-sensitive adhesive layer 2 inside the adhesive opening 11. Further, the connecting portion 6 is in contact with the base material layer 3 outside the base material opening 15 and the base material layer 3 inside the base material opening 15.
  • the upper surface of the connecting portion 6 is flush with the upper surface 13 of the base material.
  • the lower surface of the connecting portion 6 is flush with the adhesive lower surface 9.
  • connection portion 6 located on one side in the longitudinal direction is continuous with one end edge in the longitudinal direction of the wiring 16 ⁇ / b> A located on the one side in the longitudinal direction.
  • the connection portion 6 located on the other side in the longitudinal direction is continuous with the other end in the longitudinal direction of the wiring 16B located on the other side in the longitudinal direction at the upper end thereof.
  • the connecting portion 6 is electrically connected to the wiring layer 4.
  • connection part 6 electrically connects the wiring layer 4 and the probe 5.
  • the connecting portion 6 and the wiring layer 4 constitute a circuit portion 36 that electrically connects the probe 5 to the electronic component 31. That is, the circuit unit 36 includes the wiring layer 4 disposed on the base material upper surface 13 of the base material layer 3 and the connection part 6 that passes through the base material layer 3 and the pressure-sensitive adhesive layer 2. Preferably, the circuit unit 36 includes only the wiring layer 4 and the connection unit 6.
  • Examples of the material of the connecting portion 6 include metals, conductive resins (including conductive polymers), and preferably include conductive resins.
  • the thickness (vertical length) of the connecting portion 6 is the same as the total thickness T1 of the pressure-sensitive adhesive layer 2 and the base material layer 3.
  • the length of the connecting portion 6 in the radial direction is 1 ⁇ m or more, preferably 100 ⁇ m or more, and less than 2000 ⁇ m, preferably 1000 ⁇ m or less, more preferably 500 ⁇ m or less. It is.
  • an analog front end for processing and storing an electrical signal from a living body acquired by the probe 5, a microcomputer, a memory, and further, an electrical signal is converted into a radio wave, which is received externally
  • Examples include a communication IC for wireless transmission to a machine, a transmitter, and the like.
  • the patch-type biosensor 30 is a patch-type electrocardiograph
  • the heart potential change acquired by the probe 5 is converted into digital data by the analog front end, and the heart potential change is stored in the memory. Record.
  • heart potential changes are recorded in memory at a 16 bit, 1 kHz data rate. In order to reduce the memory size, the data resolution and data rate may be lowered.
  • the recorded data is analyzed by taking out the data from the memory after the pasted biosensor 30 is removed after the measurement. Further, the communication IC has a function of wirelessly transmitting a signal acquired by the probe 5 to the outside.
  • This function can be used to confirm that the data acquisition is normally performed when it is possible to confirm that the data acquisition is normal when the patch-type biosensor 30 is applied to the skin 33 in the case of continuous connection. It is activated when it is intermittently sent to the outside and it is confirmed that the paste-type biosensor 30 is operating normally.
  • the electronic component 31 may have some or all of the above.
  • the electronic component 31 is in contact with the upper surface 13 of the base material.
  • the electronic component 31 has a substantially rectangular flat plate shape in sectional view.
  • Two terminals 35 are provided on the lower surface of the electronic component 31.
  • Each of the two terminals of the electronic component 31 is electrically connected to each of the first terminal 17A and the third terminal 17C.
  • the electronic component 31 is harder than the pressure-sensitive adhesive layer 2 and the base material layer 3, for example.
  • the thickness T6 of the electronic component 31 is, for example, 1 ⁇ m or more, preferably 10 ⁇ m or more, and for example, 1000 ⁇ m or less, preferably 500 ⁇ m or less.
  • the thickness T6 of the electronic component 31 is equal to or less than the above upper limit, the total thickness T7 of the pasting-type biosensor 30 can be reduced.
  • the thickness T6 of the electronic component 31 is equal to or greater than the lower limit described above, the handleability and mountability of the electronic component 31 can be improved.
  • the plane area S of the electronic component 31, that is, the cross-sectional area S when the electronic component 31 is cut along the plane direction is, for example, 0.001 mm 2 or more, preferably 0.01 mm 2 or more, more preferably. 0.05 mm 2 or more, and for example, 10 mm 2 or less, preferably 2 mm 2 or less, more preferably 1 mm 2 or less. If the plane area S of the electronic component 31 is equal to or less than the above-described upper limit, it is possible to further reduce the feeling of wearing the adhesive biosensor 30 on the living body.
  • the handling and mounting properties of the electronic component 31 can be improved.
  • the thickness T7 of the adhesive biosensor 30 is the total thickness (T2 + T3 + T6) of the total thickness T1 of the pressure-sensitive adhesive layer 2 and the base material layer 3 and the thickness T6 of the electronic component 31, and is, for example, 2 ⁇ m or more.
  • the thickness is preferably 20 ⁇ m or more, and is, for example, 1000 ⁇ m or less, preferably 100 ⁇ m or less.
  • a base material layer 3 and a wiring layer 4 are prepared.
  • the base material layer 3 and the wiring layer 4 are prepared so that the wiring layer 4 is embedded in the base material groove 14 by a method described in Japanese Patent Application Laid-Open Nos. 2017-2222236 and 2017-22237.
  • the pressure-sensitive adhesive layer 2 is arranged on the lower surface 12 of the base material.
  • the pressure-sensitive adhesive layer 2 In order to arrange the pressure-sensitive adhesive layer 2 on the lower surface 12 of the substrate, for example, first, a coating liquid containing the material of the pressure-sensitive adhesive layer 2 is prepared, and then the coating liquid is applied to the upper surface of the first release sheet 19. It is applied and then dried by heating. Thereby, the pressure-sensitive adhesive layer 2 is disposed on the upper surface of the first release sheet 19.
  • the first release sheet 19 has, for example, a substantially flat plate shape that extends in the longitudinal direction. Examples of the material of the first release sheet 19 include resins such as polyethylene terephthalate.
  • the pressure-sensitive adhesive layer 2 and the base material layer 3 are bonded together by, for example, a laminator. Specifically, the adhesion upper surface 8 of the pressure-sensitive adhesive layer 2 and the substrate lower surface 12 of the substrate layer 3 are brought into contact with each other.
  • the base material layer 3 and the pressure-sensitive adhesive layer 2 do not have the base material opening 15 and the adhesive opening 11, respectively.
  • the opening 23 is formed in the base material layer 3 and the pressure-sensitive adhesive layer 2.
  • the opening 23 penetrates the base material layer 3 and the pressure-sensitive adhesive layer 2.
  • the opening 23 is a substantially circular hole (through hole) in plan view defined by an outer peripheral surface that defines the base material opening 15 and an outer peripheral surface that defines the bonding opening 11.
  • the opening 23 is opened upward.
  • the lower end of the opening 23 is closed by the first release sheet 19.
  • the pressure-sensitive adhesive layer 2 and the base material layer 3 are punched and half-etched, for example.
  • the probe member 18 is prepared and fitted into the opening 23.
  • a probe-containing sheet 26 is prepared as shown in FIG.
  • the probe-containing sheet 26 includes a second release sheet 29, a probe pattern 25 formed on the second release sheet 29, and a pressure-sensitive adhesive layer 2 formed on the second release sheet 29 to embed the probe pattern 25. And a base material layer 3 disposed on the adhesive upper surface 8 of the pressure-sensitive adhesive layer 2.
  • the second release sheet 29 has the same configuration as the first release sheet 19 described above.
  • the probe pattern 25 has the same pattern shape as the probe 5, and the material of the probe pattern 25 is the same as the material of the probe 5.
  • the probe pattern 25 has a larger plane area than the virtual circle that passes through the outer surface 22 of the probe 5.
  • Each of the pressure-sensitive adhesive layer 2 and the base material layer 3 in the probe-containing sheet 26 has the same configuration as each of the pressure-sensitive adhesive layer 2 and the base material layer 3 described above.
  • the probe-containing sheet 26 is prepared by a method described in, for example, Japanese Patent Application Laid-Open No. 2017-22236 and Japanese Patent Application Laid-Open No. 2017-22237.
  • a photoresist is laminated on the entire upper surface of the seed layer.
  • the photoresist is exposed and developed to form a photoresist in the reverse pattern of the probe pattern 25.
  • the photoresist is removed.
  • a coating solution containing the material for the pressure-sensitive adhesive layer 2 is applied so as to cover the probe pattern 25 and cured to form the pressure-sensitive adhesive layer 2.
  • the base material layer 3 is bonded to the upper surface of the pressure-sensitive adhesive layer 2 using, for example, a laminator.
  • the second release sheet 29 has the same configuration as the first release sheet 19 described above.
  • the cutting line 27 is formed in the probe pattern 25, the pressure-sensitive adhesive layer 2, and the base material layer 3 in a substantially circular shape in plan view.
  • the cutting line 27 is formed by, for example, punching.
  • the cutting line 27 divides the probe pattern 25, the pressure-sensitive adhesive layer 2 and the base material layer 3 into and out of the probe pattern 25, but is not formed on the second release sheet 29.
  • the dimension of the cutting line 27 is the same as the inner diameter of the bonding opening 11 and the base material opening 15. That is, the cutting line 27 coincides with a virtual circle that passes through the outer surface 22.
  • the probe member 18 is formed by forming the cutting line 27.
  • the outer surface 22 of the probe 5 is flush with the outer surface of the pressure-sensitive adhesive layer 2. In the probe member 18, the outer surface 22 is exposed radially outward from the outer surface of the pressure-sensitive adhesive layer 2.
  • the probe member 18 is pulled up from the second release sheet 29. Specifically, the adhesive lower surface 9 and the probe lower surface 20 in the probe member 18 are peeled from the second release sheet 29.
  • the probe member 18 is fitted into the opening 23 as shown by the arrow in FIG. 3C.
  • a space is provided between the pressure-sensitive adhesive layer 2, the base material layer 3 and the probe 5 of the probe member 18 and the pressure-sensitive adhesive layer 2 and the base material layer 3 around the opening 23. That is, the probe member 18 is fitted into the opening 23 so that the base material opening 15 and the bonding opening 11 are formed.
  • the connecting portion 6 is provided in the base material opening 15 and the bonding opening 11.
  • the conductive resin composition is injected (or applied) into the base material opening 15 and the adhesive opening 11. Thereafter, the conductive resin composition is heated as necessary.
  • the biosensor laminate 1 including the first release sheet 19, the pressure-sensitive adhesive layer 2, the base material layer 3, the wiring layer 4, the probe 5, and the connection portion 6 is produced.
  • the laminated body 1 for biosensors is a device which is distributed by itself and can be used industrially.
  • the biosensor laminate 1 can be distributed separately from the electronic component 31 and the battery 32 (see the phantom line in FIG. 1) described below. That is, the biosensor laminate 1 is a component for manufacturing the adhesive biosensor 30 without mounting the electronic component 31 and the battery 32.
  • each of the two terminals 35 in the electronic component 31 is electrically connected to each of the first terminal 17A and the third terminal 17C.
  • the lower surface of the electronic component 31 is brought into contact with the upper surface 13 of the base material.
  • This pasted-type biosensor 30 includes a pressure-sensitive adhesive layer 2, a base material layer 3, a wiring layer 4, a probe 5, a connection portion 6, an electronic component 31, and a first release sheet 19, and preferably Consists only of them. As shown in FIG. 2A, the adhesive biosensor 30 does not include the first release sheet 19, and includes the pressure-sensitive adhesive layer 2, the base material layer 3, the wiring layer 4, the probe 5, and the connection portion 6.
  • the electronic component 31 may be used alone.
  • the battery 32 is mounted on the pasting-type biosensor 30.
  • the battery 32 has a substantially flat (box) shape extending in the surface direction.
  • the battery 32 has two terminals (not shown) provided on the lower surface thereof.
  • the thickness of the battery 32 is, for example, 1 ⁇ m or more, preferably 10 ⁇ m or more, and for example, 1000 ⁇ m or less, preferably 100 ⁇ m or less.
  • two terminals (not shown) of the battery 32 are electrically connected to the second terminal 17B and the fourth terminal 17D, respectively. At that time, the lower surface of the battery 32 is brought into contact with the upper surface 13 of the base material.
  • the first release sheet 19 (see the arrows and phantom lines in FIG. 3D) is peeled from the pressure-sensitive adhesive layer 2 and the probe 5.
  • the adhesive lower surface 9 of the pressure-sensitive adhesive layer 2 is then brought into contact with the human skin 33, for example. Specifically, the pressure-sensitive adhesive layer 2 is pressure-bonded to the surface of the skin 33.
  • the probe lower surface 20 of the probe 5 comes into contact with the surface of the skin 33 by the pressure-sensitive adhesion (sticking) of the adhesion lower surface 9 to the skin 33.
  • the probe 5 senses an electrical signal from the living body, and the electrical signal sensed by the probe 5 is input to the electronic component 31 via the connection unit 6 and the wiring layer 4.
  • the electronic component 31 processes an electrical signal based on the power supplied from the battery 32 and stores it as information. Furthermore, if necessary, the electric signal is converted into a radio wave and wirelessly transmitted to an external receiver.
  • Examples of the adhesive biosensor 30 include an apparatus that can sense an electrical signal from a living body and monitor the state of the living body, and specifically includes an adhesive electrocardiograph, an adhesive electroencephalograph, and an adhesive blood pressure. Examples include a meter, a patch-type pulse meter, a patch-type electromyograph, a patch-type thermometer, and a patch-type accelerometer. These devices may be individual devices, or a plurality of devices may be incorporated in one device.
  • the adhesive biosensor 30 is preferably used as an adhesive electrocardiograph.
  • the probe 5 senses the cardiac action potential as an electrical signal.
  • the living body includes a human body and a living body other than the human body, and is preferably a human body.
  • the pasting type biosensor 30 since the total thickness T1 of the pressure sensitive adhesive layer 2 and the base material layer 3 is as thin as 1 ⁇ m or more and less than 100 ⁇ m, the pasting type biosensor 30 is stuck on the skin 33. However, it is possible to sufficiently reduce the feeling of wearing on the living body, particularly the human body.
  • the disposable patch-type biosensor 30 can then be collected if necessary, and for example, the electronic component 31 and further the battery 32 can be taken out and recycled.
  • the thickness T2 of the pressure-sensitive adhesive layer 2 is equal to or less than the above-described upper limit, the total thickness T1 of the pressure-sensitive adhesive layer 2 and the base material layer 3 can be set to be lower than the upper limit. It is possible to reduce the thickness of the sensor 30, and in particular, to reduce the thickness of the area other than the electronic component 31 in the pasting type biosensor 30. Further, the thickness T2 of the pressure-sensitive adhesive layer 2 can provide sufficient pressure-sensitive adhesiveness to the skin 33 of the adhesive biosensor 30.
  • the thickness T6 of the electronic component 31 is equal to or less than the above upper limit, the total thickness T7 of the adhesive biosensor 30 can be reduced.
  • the thickness T6 of the electronic component 31 is equal to or greater than the lower limit described above, the handleability and mountability of the electronic component 31 can be improved.
  • the flat area S of the electronic component 31 is less than or equal to the above upper limit, the wearing feeling of the adhesive biosensor 30 can be further reduced with respect to the living body. If the plane area S of the electronic component 31 is equal to or greater than the lower limit described above, the handleability and mountability of the electronic component 31 can be improved.
  • the line passing through the outer surface 22 is circular, but the shape is not particularly limited.
  • the line may be rectangular. Good.
  • the entire side surface (except the outer surface 22) of the probe 5 is in contact with the pressure-sensitive adhesive layer 2, and the probe lower surface 20 of the probe 5 is connected to the pressure-sensitive adhesive layer 2. It is flush with the adhesive lower surface 9.
  • the upper portion of the side surface (excluding the outer surface 22) of the probe 5 can be in contact with the pressure-sensitive adhesive layer 2, and the lower portion can be exposed from the adhesive lower surface 9.
  • the probe lower surface 20 is positioned below the bonding lower surface 9. That is, only the upper part of the probe 5 is embedded in the pressure-sensitive adhesive layer 2, and the lower part of the probe 5 protrudes downward from the adhesive lower surface 9.
  • the entire probe 5 can also protrude downward from the adhesive lower surface 9.
  • the bonding lower surface 9 does not have the bonding groove 10 and has a flat surface.
  • the entire side surface of the wiring layer 4 is in contact with the base material layer 3.
  • the lower part of the side surface of the wiring layer 4 is in contact with the base material layer 3, and the upper part of the side surface of the wiring layer 4 is from the base material upper surface 13 of the base material layer 3. Exposed. That is, the upper part of the wiring layer 4 protrudes from the upper surface 13 of the base material layer 3 and the lower part of the wiring layer 4 is embedded in the base material layer 3.
  • the entire side surface of the wiring layer 4 can be exposed.
  • the substrate upper surface 13 does not have the substrate groove 14 and is a flat surface.
  • the lower surface of the wiring layer 4 is placed in contact with the substrate upper surface 13.
  • the wiring layer 4 may be completely embedded in the base material layer 3. That is, the wiring layer 4 is embedded in the base material layer 3. The upper surface, the lower surface, and the side surfaces of the wiring layer 4 are all covered with the base material layer 3. The wiring layer 4 is located between the substrate upper surface 13 and the substrate lower surface 12 in the substrate layer 3.
  • the wiring layer 4 is embedded in the base material layer 3 so as to be exposed from the base material lower surface 12.
  • the lower surface of the wiring layer 4 is flush with the lower surface 12 of the base material and contacts the bonding upper surface 8.
  • the connection portion 6 does not pass through the base material layer 3 but passes only through the pressure-sensitive adhesive layer 2. That is, the connection portion 6 is filled only in the bonding opening 11.
  • the wiring layer 4 can be provided on both the pressure-sensitive adhesive layer 2 and the base material layer 3. Specifically, the upper part of the wiring layer 4 is embedded in the base material layer 3, and the lower part of the wiring layer 4 is embedded in the pressure-sensitive adhesive layer 2.
  • the wiring layer 4 can be embedded only in the pressure-sensitive adhesive layer 2.
  • the wiring layer 4 is exposed from the bonding upper surface 8 of the pressure-sensitive adhesive layer 2.
  • the wiring layer 4 is completely embedded without being exposed from either the adhesive upper surface 8 or the adhesive lower surface 9 of the pressure-sensitive adhesive layer 2.
  • connection portion 6 has an endless shape in plan view. However, for example, as shown in FIG. 9 and FIG. .
  • the connecting portion 6 has a substantially half ring shape (or a substantially semicircular arc shape) in plan view.
  • the connecting portion 6 includes an upper end portion 37 having a substantially half ring shape in plan view, and a plurality of first filaments 38 continuing to the upper end portion 37.
  • the first filament 38 extends downward from the lower end edge of the upper end portion 37.
  • the lower end portion of the first filament 38 is in contact with the outer surface 22.
  • a plurality of first filaments 38 are arranged along the virtual semicircle along the upper end portion 37 at intervals.
  • the upper end portion 37 of the connecting portion 6 has an endless shape in plan view, and a portion located below the upper end portion 37 is a cross-sectional view in the bottom view (or in the plane direction). It may be an end shape as viewed (plan view).
  • the upper end portion 37 has a substantially ring shape in plan view.
  • the connecting portion 6 has a slit 39 formed on the lower side of the upper end portion 37.
  • a plurality of slits 39 are provided at intervals along a virtual circle along the upper end portion 37. That is, the connection part 6 has a substantially cylindrical shape in which a plurality of slits 39 are formed.
  • connection portion 6 has an upper end portion 37 and a second wire 43 that hangs down from the lower end edge thereof.
  • a plurality of second filaments 43 are arranged at intervals along a virtual circle along the upper end portion 37. The lower ends of the plurality of second filaments 43 are in contact with the outer surface 22.
  • the connecting portion 6 is integrally provided with an upper end portion 37 and a net portion 44 located below the upper end portion 37.
  • the upper end portion of the net portion 44 is continuous with the lower end edge of the upper end portion 37.
  • the lower end portion of the net 44 is in contact with the outer surface 22.
  • the probe 5 does not have a hole and can have a substantially plate shape (specifically, a substantially disk shape) extending in the surface direction.
  • the outer peripheral surface of the probe 5 is in contact with the inner peripheral surface of the lower end portion of the connection portion 6.
  • the probe 5 may have a substantially columnar shape (specifically, a substantially cylindrical shape) that passes through the pressure-sensitive adhesive layer 2 and the base material layer 3.
  • the probe upper surface 21 is exposed from the substrate upper surface 13 of the substrate layer 3 and the upper surface of the connection portion 6.
  • the entire outer peripheral surface of the probe 5 is in contact with the entire inner peripheral surface of the connection portion 6.
  • the connecting portion 6 may have a substantially bar (round bar) (needle) shape whose axis extends along the thickness direction.
  • the connecting part 6 and the probe 5 are in a point-like contact.
  • the connecting portion 6 has a substantially columnar shape
  • the probe 5 has a substantially plate shape (specifically, a substantially disc shape) that does not have a hole and extends in the surface direction. be able to.
  • a conductive pressure-sensitive adhesive layer 28 can be provided on the lower surface of the probe 5.
  • the conductive pressure-sensitive adhesive layer 28 is provided in order to suppress a decrease in sensing accuracy and noise caused by a difference in moisture content and surface unevenness in the skin 33 depending on a living body (individual), and moisture for adjusting the moisture content in the skin 33. It may have a function of adjusting the amount (or stabilizing the amount of water).
  • the material of the conductive pressure-sensitive adhesive layer 28 may include a conductive material (for example, a hydrophilic compound) having a moisture content adjusting function (or moisture content stabilizing function).
  • the materials include pressure sensitive adhesives such as silicone, acrylic and urethane, and hydrophilic polymers such as polyethylene oxide (PEO), polyvinyl alcohol (PVA), polyvinyl pyrrolidone (PVP) and polyethylene glycol (PEG).
  • PEO polyethylene oxide
  • PVA polyvinyl alcohol
  • PVP polyvinyl pyrrolidone
  • PEG polyethylene glycol
  • a hole of the probe 5 may be filled with a pressure sensitive and strong adhesive layer 45.
  • the lower surface of the pressure-sensitive strong adhesive layer 45 is flush with the probe lower surface 20 and the adhesive lower surface 9.
  • Examples of the material of the pressure-sensitive strong adhesive layer 45 include pressure-sensitive strong adhesives such as silicone, acrylic, and urethane.
  • the peel peel strength of the pressure sensitive adhesive layer 45 is, for example, 1.5 times or more that of the pressure sensitive adhesive layer 2. Since the probe 5 is firmly fixed to the skin 33 by the pressure-sensitive strong adhesive layer 45, the signal processing accuracy is further improved.
  • the probe 5 and the connecting portion 6 may be integrated.
  • the probe 5 also serves as the connection portion 6.
  • the probe 5 has a solid substantially cylindrical shape.
  • the probe lower surface 20 is exposed from the adhesive lower surface 9.
  • the probe upper surface 21 is exposed from the substrate upper surface 13.
  • One end edge in the longitudinal direction of the first wiring 16A and the other edge in the longitudinal direction of the second wiring 16B are in contact with the upper ends of the two probes 5, respectively.
  • Examples of the material of the probe 5 include the same material as that of the connection portion 6.
  • the circuit unit 36 may be a circuit unit 36 integrally including the wiring layer 4 and the connection unit 6.
  • the connecting portion 6 may be smaller than the probe 5 in plan view.
  • the virtual circle 34 that passes through the outer surface 22 of the probe 5 includes the connection portion 6 and is larger than the connection portion 6 in plan view.
  • the lower end edge of the connecting portion 6 is in contact with a portion in the surface direction of the probe 5 (a portion on the inner side of the outer surface 22).
  • the center part in the longitudinal direction of the adhesive biosensor 30 is swollen.
  • the present invention is not limited to this example.
  • the portion does not swell and may have a substantially rectangular shape in plan view.
  • the biosensor laminate 1 can further include a protective member 50.
  • the protective member 50 is positioned at the upper end of the biosensor laminate 1. Specifically, the protection member 50 is disposed on the base material upper surface 13 of the base material layer 3 so as to close the upper surface of the wiring layer 4.
  • the protection member 50 has a sheet shape along the upper surface 13 of the base material. Therefore, the protective member 50 is a protective layer (upper surface protective layer) that protects the upper surface 13 of the base material and the upper surface of the wiring layer 4.
  • the protective member 50 includes, for example, a protective substrate 51 and a second pressure-sensitive adhesive layer 52.
  • the protective member 50 includes a protective base material 51 and a second pressure-sensitive adhesive layer 52 in order toward the lower side.
  • the protection member 50 includes only a protection base 51 and a second pressure-sensitive adhesive layer 52.
  • the second pressure-sensitive adhesive layer 52 is in contact with the upper surface 13 of the base material and the upper surface of the wiring layer 4.
  • Examples of the material of the second pressure-sensitive adhesive layer 52 include acrylic pressure-sensitive adhesives, silicone-based pressure-sensitive adhesives, polyolefin-based pressure-sensitive adhesives, and epoxy-based pressure-sensitive adhesives. From the viewpoint of obtaining high moisture permeability, an acrylic pressure-sensitive adhesive can be used.
  • the thickness of the second pressure-sensitive adhesive layer 52 is, for example, 1 ⁇ m or more, for example, 50 ⁇ m or less.
  • the protective substrate 51 is disposed on the upper surface of the second pressure-sensitive adhesive layer 52.
  • the protective substrate 51 has a sheet shape along the upper surface of the second pressure-sensitive adhesive layer 52.
  • the protective substrate 51 is in contact with the upper surface of the second pressure-sensitive adhesive layer 52.
  • Resin is mentioned as a material of the protective base material 51.
  • the resin include thermoplastic resins such as polyurethane resins, silicone resins, acrylic resins, polystyrene resins, vinyl chloride resins, and polyester resins, and are preferable from the viewpoint of ensuring excellent stretchability. May be a polyurethane-based resin.
  • the thickness of the protective substrate 51 is, for example, 0.1 ⁇ m or more, for example, 50 ⁇ m or less.
  • the thickness of the protective member 50 is the sum of the thickness of the protective substrate 51 and the thickness of the second pressure-sensitive adhesive layer 52, and is 1.1 ⁇ m or more, for example, 51 ⁇ m or less.
  • the protective member 50 can be made of only the protective substrate 51 without including the second pressure-sensitive adhesive layer 52.
  • the protective substrate 51 is directly disposed on the upper surface 13 of the substrate and the upper surface of the wiring layer 4, and specifically, is in contact with those surfaces.
  • the said invention was provided as exemplary embodiment of this invention, this is only a mere illustration and should not be interpreted limitedly. Variations of the present invention that are apparent to one of ordinary skill in the art are within the scope of the following claims.
  • the biosensor is used for, for example, an adhesive biosensor.

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Abstract

La présente invention concerne un biocapteur qui est équipé d'une couche adhésive sensible à la pression pour la fixation à une surface de corps vivant, d'une couche de substrat étirable disposée sur la surface supérieure de la couche adhésive sensible à la pression, d'une sonde disposée sur la surface inférieure de la couche adhésive sensible à la pression, et d'un composant électronique monté sur la couche de substrat de sorte à être connecté à la sonde, l'épaisseur totale de la couche adhésive sensible à la pression et de la couche de substrat étant supérieure ou égale à 1 µm et inférieure à 100 µm.
PCT/JP2018/010199 2017-04-28 2018-03-15 Biocapteur WO2018198569A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201880027341.4A CN110545718B (zh) 2017-04-28 2018-03-15 生物传感器
US16/608,975 US20200187859A1 (en) 2017-04-28 2018-03-15 Biosensor
EP18792289.3A EP3616607A4 (fr) 2017-04-28 2018-03-15 Biocapteur

Applications Claiming Priority (4)

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JP2017090539 2017-04-28
JP2017-090539 2017-04-28
JP2018040596A JP7033469B2 (ja) 2017-04-28 2018-03-07 生体センサ
JP2018-040596 2018-03-07

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WO2018198569A1 true WO2018198569A1 (fr) 2018-11-01

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020181987A1 (fr) * 2019-03-12 2020-09-17 深圳碳云智能数字生命健康管理有限公司 Dispositif de collecte d'électrocardiographie miniature, collecteur et machine principale

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003342541A (ja) 2002-05-29 2003-12-03 Nitto Denko Corp 粘着シート
JP2004083425A (ja) 2002-08-23 2004-03-18 Nitto Denko Corp 皮膚貼着用粘着部材
WO2013065147A1 (fr) * 2011-11-02 2013-05-10 ニプロ株式会社 Électrocardiographe et bioélectrode
JP2015123198A (ja) * 2013-12-26 2015-07-06 フクダ電子株式会社 生体電極
JP2015123199A (ja) * 2013-12-26 2015-07-06 フクダ電子株式会社 生体電極
JP2017022236A (ja) 2015-07-09 2017-01-26 日東電工株式会社 配線回路基板の製造方法
JP2017022237A (ja) 2015-07-09 2017-01-26 日東電工株式会社 配線回路基板

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2836904C2 (de) * 1978-08-23 1980-07-03 Siemens Ag, 1000 Berlin Und 8000 Muenchen Klebehalterung
US20150335288A1 (en) * 2013-06-06 2015-11-26 Tricord Holdings, Llc Modular physiologic monitoring systems, kits, and methods
US10278581B2 (en) * 2013-08-08 2019-05-07 Bloom Technologies NV Wireless pregnancy monitor
CN204072086U (zh) * 2014-07-16 2015-01-07 上海英科医疗用品有限公司 一种心电监护电极片

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003342541A (ja) 2002-05-29 2003-12-03 Nitto Denko Corp 粘着シート
JP2004083425A (ja) 2002-08-23 2004-03-18 Nitto Denko Corp 皮膚貼着用粘着部材
WO2013065147A1 (fr) * 2011-11-02 2013-05-10 ニプロ株式会社 Électrocardiographe et bioélectrode
JP2015123198A (ja) * 2013-12-26 2015-07-06 フクダ電子株式会社 生体電極
JP2015123199A (ja) * 2013-12-26 2015-07-06 フクダ電子株式会社 生体電極
JP2017022236A (ja) 2015-07-09 2017-01-26 日東電工株式会社 配線回路基板の製造方法
JP2017022237A (ja) 2015-07-09 2017-01-26 日東電工株式会社 配線回路基板

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP3616607A4

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020181987A1 (fr) * 2019-03-12 2020-09-17 深圳碳云智能数字生命健康管理有限公司 Dispositif de collecte d'électrocardiographie miniature, collecteur et machine principale

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CN110545718A (zh) 2019-12-06

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