WO2018188366A1 - 一种生物胶原蛋白面膜基材及其应用 - Google Patents

一种生物胶原蛋白面膜基材及其应用 Download PDF

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WO2018188366A1
WO2018188366A1 PCT/CN2017/116213 CN2017116213W WO2018188366A1 WO 2018188366 A1 WO2018188366 A1 WO 2018188366A1 CN 2017116213 W CN2017116213 W CN 2017116213W WO 2018188366 A1 WO2018188366 A1 WO 2018188366A1
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collagen
parts
mask
bio
mask substrate
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PCT/CN2017/116213
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English (en)
French (fr)
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周亚仙
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梧州神冠蛋白肠衣有限公司
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Priority to SG11201902245T priority Critical patent/SG11201902245TA/en
Publication of WO2018188366A1 publication Critical patent/WO2018188366A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0212—Face masks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A61K8/355—Quinones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A61K8/585—Organosilicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin

Definitions

  • the invention relates to a bio-collagen mask substrate and an application thereof, and belongs to the technical field of biomaterial application.
  • Collagen is a natural protein composed of 19 kinds of amino acids such as glycine, alanine and proline. It mainly exists in the skin, cartilage, ligament, tendon and other connective tissues of animals, plays a role of support and protection, and is an important structural protein of connective tissue.
  • the mask substrate is naturally non-irritating, safe to use, and prevents the chemical raw materials from invading the skin. All kinds of skin including allergic skin can be used safely; the mask substrate is soft and smooth, like the second layer of the human body, and specific The combination of the formulated mask liquid can give consumers a quality experience.
  • a bio-collagen mask substrate prepared by the following method:
  • the bio-collagen is extracted from the skin of the animal, and the specific method is:
  • the animal skin is divided into 5-20 mm 2 .
  • the animal skin is cowhide, pig skin or other animal skin.
  • the protease is pepsin, papain or trypsin.
  • the alkali treatment is preferably lyophilized with lime milk for 1-2 days, and then rinsed with water;
  • the acid treatment is preferably carried out by soaking for 4 hours with 0.1-0.5 M hydrochloric acid or lactic acid solution, and then changing the animal skin with lactic acid. In the form of translucent swelling, the acid solution was drained and washed with water for 3-4 times.
  • the oil emulsion is prepared by heating the edible fat and oil into a liquid, adding water according to a weight ratio of edible oil to water 1:1, heating, and colloidal grinding; the edible fat is Hydrogenated fats, margarines or shortenings.
  • the edible cellulose or edible cellulose derivative is used in an amount of 1-3% by weight of the animal skin, and the oil emulsion is 1-5% by weight of the animal skin, and the pH is controlled to 2.5- 3.5, water content is 88-94%.
  • the shape of the mask substrate of the present invention can be tailored according to actual use requirements. For example, directly cut into the shape of the entire mask that is currently the most commonly used commercially available, and open holes in the corresponding parts of the eyes, nose and mouth; Alternatively, the mask substrate is cut into a plurality of planar portions to form a segmented mask substrate, such as the lower two parts, the left and right portions, or more; or the body 3D structure is cut to facilitate different facial users according to the face. More targeted facials in different locations.
  • the mask substrate is a segmented mask substrate, and the face is divided into an upper part and a lower part by a lower part of the nose, according to the upper part and the lower part of the face.
  • the shape of the mold is partially adjusted, and each part of the mask substrate is prepared according to the preparation method of the above mask substrate. As shown in Figure 1-4.
  • the specific size of the segmented mask substrate is as follows: the upper half of the facial mask substrate has a length of 230 ⁇ 5 mm and a width of 102 ⁇ 5 mm; wherein the facial upper half of the facial mask substrate is provided at a corresponding position in the eye.
  • Eyelet eyelet is elliptical, with a long axis of 50 ⁇ 2mm and a minor axis of 20 ⁇ 2mm; there are six openings on the lower edge of the upper half of the facial mask substrate, wherein the two openings are located at the lower edge of the two At the end, the distance is 190 ⁇ 5mm; the other four openings are located on both sides of the nose part of the mask base material, so that the user can adjust the mask base material to make it more conformable to the face; the openings on both sides of the nose part of the mask base material are provided. Symmetrical arrangement, the distance between the two farthest openings is 60 ⁇ 2mm, and the distance between the two openings is 40 ⁇ 2mm.
  • the lower part of the facial mask has a length of 230 ⁇ 5mm and a width of 100 ⁇ 5mm.
  • the corresponding part of the nose is provided with a notch and the width is 45 ⁇ 2mm, so as to prevent the mask liquid from affecting the user's breathing;
  • the lower part of the facial mask base lip The opening is elliptical, the long axis is 63 ⁇ 2mm, the short axis is 20 ⁇ 2mm, and the lower end of the notch of the nose is 13 ⁇ 2mm from the upper end of the lip opening.
  • the lower end of the mask part of the lower part of the face is also set.
  • the mask substrate is a 3D mask substrate
  • the shape of the mold can be adjusted according to the left face, the right face, and the mouth and nose triangles, and then the masks are prepared according to the above method, and the collagen is utilized.
  • a special adhesive is used to bond the masks of the respective parts, and the 3D round face is cut by the shape of the mold to obtain a 3D collagen mask substrate. As shown in Figure 5-10.
  • the 3D mask substrate is divided into a left face portion, a right face portion and a mouth-nose triangle portion; wherein the left face portion of the 3D mask substrate has a length of 203 ⁇ 5 mm.
  • the upper end has a width of 88 ⁇ 5 mm and the lower end has a width of 106 ⁇ 5 mm;
  • the eye opening is elliptical, the long axis is 46 ⁇ 2 mm, and the short axis is 19 ⁇ 2 mm;
  • the right face portion and the left face portion are mirror images;
  • the triangular portion of the mouth and nose of the 3D mask substrate has a three-dimensional structure with low middle and high sides, the length of the middle edge is 109 ⁇ 5 mm, and the distance between the left and right ends to the middle edge is 48 ⁇ 2 mm; in the 3D mask base
  • the mouth-nose triangle portion of the material has a nostril and a lip hole corresponding to the tip of the nose and the lip, and the middle rib is divided into five segments, which are 20 ⁇ 2 mm, 13 ⁇ 2 mm, 13 ⁇ 2 mm, 20 ⁇ 2 mm, and 43 ⁇ 2 mm, respectively;
  • the most distal end of the nostril is 26 ⁇ 2mm from the middle edge, and the most distal end of the lip is 35 ⁇ 2mm from the middle edge.
  • the present invention also provides a mask comprising the above-described bio-collagen mask substrate and a mask liquid.
  • the mask liquid is composed of the following components by weight: water 80.0-90.0 parts, 1,3-propanediol 1.0-5.0 parts, glycerol 1.0-5.0 parts, methyl silanol hydroxyproline ester aspartate 0.05 -3.0 parts, hydrolyzed jojoba esters 0.01-1.0 parts, sodium hyaluronate 0.1-2.0 parts, mother chrysanthemum (CHAMOMILLARECUTITA) extract 0.1-2.0 parts, glycoprotein 0.1-1.0 parts, Aloes Barley Aloe (ALOEBARBADENSIS) leaves 0.2-3.0 parts of extract, 0.1-1.0 parts of CENTELLAASIATICA extract, 0.1-1.0 parts of STEPHANIATETRANDRA extract, 0.1-0.8 parts of ubiquinone, 0.1-0.8 parts of macadamia (IFADAMIATERNIFOLIA) seed oil , PEG/PPG/polybutylene glycol-8/5/3 glycerol 0.1-1.0 parts
  • the mask liquid is composed of the following components by weight: 85-88 parts of water, 4-5 parts of 1,3-propanediol, 3-5 parts of glycerin, methyl silanol hydroxyl 0.1-0.2 parts of proline ester aspartate, 0.01-0.02 parts of hydrolyzed jojoba ester, sodium hyaluronate 0.1-0.15 parts, 0.1-0.15 parts of CHAMOMILLARECUTITA extract, 0.1-0.15 parts of glycoprotein, 0.2-0.25 parts of leaf extract of Aloe Barrow (ALOEBARBADENSIS), CENTELLAASIATICA extract 0.1-0.15 , 0.1-0.15 parts of STEPHANIATETRANDRA extract, 0.1-0.15 parts of ubiquinone, 0.1-0.15 parts of macadamia nut oil (MACADAMIATERNIFOLIA), PEG/PPG/polybutylene glycol-8/5/3 glycerol 0.4- 0.6 parts, 0.5
  • the invention adopts bio-collagen as a raw material, and is made into a mask base material by originality, and successfully replaces the problem of allergy and the like existing in the existing non-woven fabric mask substrate.
  • the mask substrate of the invention has good permeability, natural and no stimulation, and utilizes its unique structural features and perfect bonding ability with the skin, so that the essence can be better penetrated into the skin without anti-absorption or residue. , high-efficiency moisturizing, make the facial skin care essence absorb more thoroughly.
  • Figure 1 is a schematic overall view of the collagen membrane of Example 1.
  • Figure 2 is a view showing the overall size of the collagen membrane of Example 1.
  • Fig. 3 is a view showing the size of the upper face collagen membrane in Example 1.
  • Example 4 is a dimensional view of a lower face collagen membrane in Example 1.
  • Fig. 5 is a perspective view showing a 3D collagen membrane mask according to Example 2.
  • Figure 6 is a plan view of the entire face collagen membrane of the mask of Example 2.
  • Fig. 7 is a view showing a collagen membrane on the upper face of the mask of Example 2.
  • Fig. 8 is a view showing a collagen membrane of the mouth-nose triangle portion of the mask of Example 2.
  • Fig. 9 is a diagram showing the left face collagen membrane of the mask of Example 2.
  • Figure 10 is a diagram showing the right face collagen membrane of the mask of Example 2.
  • the bio-collagen is placed in an extruder to obtain a tubular bio-collagen film, and a tubular collagen membrane having a diameter of 52-54 mm is placed on a fixing bracket of a tubular opener.
  • the pulley shaft is fixed on the shaft.
  • a tubular collagen membrane having a diameter of 52-54 mm is placed on the pulley shaft of the fixing bracket of the tubular edger.
  • each piece is a set, which can be applied to the face type when used.
  • the tubular collagen membrane is cut open by a cutter and flattened by a pleated flattening device.
  • the collagen membrane on the left face, the collagen membrane on the triangle of the nose and mouth, and the collagen membrane on the right face are bonded together with a special adhesive for collagen. 3D round face, get 3D collagen mask.
  • the resulting 3D mask substrate is shown in Figures 5-10.
  • the invention provides a bio-collagen mask substrate.
  • the bio-collagen mask substrate of the present invention is obtained by the following method: S1: placing bio-collagen into an extruder to obtain a tubular bio-collagen film, cutting and flattening the tubular bio-collagen film; S2: pressing The flat collagen film is stretched and stretched onto the roller of the mask forming slicer, and the customized mold is pressed on the roller. The minimum distance between the mold and the roller is adjusted by the hand wheel, and the collagen cutter is used to cut the collagen film by the rotation of the motor. , a collagen membrane is obtained.
  • the bio-collagen mask substrate provided by the invention has no natural stimulation, good permeability, safe use, and prevents the chemical raw materials from invading the skin, and all kinds of skin including allergic skin can be used safely; and the mask substrate utilizes its unique The structure features and the perfect fit with the skin, the essence can penetrate into the skin better, no anti-absorption, no residue, high-efficiency moisturizing, make the facial skin care essence absorb more thoroughly, have better economic value and application prospects. .

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Abstract

一种生物胶原蛋白面膜基材，其由生物胶原蛋白挤压、切割、压平、切断制得。所述生物胶原蛋白是从动物皮中提取得到的。该生物胶原蛋白面膜基材与面膜液组成一种面膜。

Description

一种生物胶原蛋白面膜基材及其应用 技术领域
本发明涉及一种生物胶原蛋白面膜基材及其应用，属于生物材料应用技术领域。
背景技术
胶原蛋白是由甘氨酸、丙氨酸、脯氨酸等19种氨基酸所组成的天然蛋白质。其主要存在于动物的皮、软骨、韧带、肌腱及其他结缔组织中，起支持、保护等作用，是结缔组织重要的结构蛋白。
近20年来，随着分子生物学的发展，人们对胶原性质的认识已越来越深入，有研究表明：胶原蛋白的抗原性低，具有良好的生物相容性和生物可降解性。因此，作为天然的生物质资源，胶原蛋白在食品、生物医学、化妆品等工业应用的重要性和经济地位日益突出，以胶原蛋白制成的胶原蛋白膜在上述领域内的研究也日渐活跃。
目前市场上面膜产品众多，但其中大部分都含有化工原料。即便部分产品声称采用天然原料，但仍然无法做到真正的纯天然。因此，对于过敏性肌肤消费者，特别是严重过敏体质的消费者来说，真正可以放心使用的面膜少之又少。
发明内容
本发明的目的是提供一种生物胶原蛋白面膜基材及其应用。所述面膜基材天然无刺激，使用安全，杜绝化工原料对肌肤的侵害，各类肌肤包括过敏性肌肤均可放心使用；该面膜基材柔软顺滑，尤如人体第二层肌肤，与特定配方的面膜液结合使用，能够带给消费者优质的使用体验。
本发明采用如下技术方案实现：
一种生物胶原蛋白面膜基材，由如下方法制备：
S1：将生物胶原蛋白置入挤压机，得到管状生物胶原蛋白膜，对管状生物胶原蛋白膜切割，压平；
S2：将压平的胶原蛋白膜延长拉伸到面膜成型切片机的滚轮上，使用定制的模具压在滚轮上，用手轮调整模具与滚轮的最小距离，利用电机旋转带动模具切刀压力把胶原蛋白膜切断,得到胶原蛋白膜片；
其中，步骤(1)中，所述生物胶原蛋白是从动物皮中提取得到的，具体方法为：
(1)将动物皮清洗、分割；
(2)分割的动物皮碱处理后，按动物皮与水重量比1:1加入水，用蛋白酶进行酶处理，所述蛋白酶加入量为动物皮重量的0.5-2％，在25-35℃下处理3-6小时，清洗后进行酸处理；
(3)酸处理后的动物皮冷却至10℃以下，使用切粒、压片、斩拌、研磨方式或其组合方式切碎，碾压成片，通过高压过滤提取丝质纤维；
(4)边搅拌边加入可食纤维素或可食纤维素衍生素、油脂乳液，控制pH值和含水量，混合搅拌均匀，得到生物胶原蛋白。
其中，所述步骤(1)中，将动物皮分割优选成5-20mm2。所述动物皮为牛皮、猪皮或其它动物皮。
所述步骤(2)中，所述蛋白酶为胃蛋白酶、木瓜蛋白酶或胰酶。
所述步骤(2)中，所述碱处理优选为石灰乳腌制1-2天后用水冲洗干净；酸处理优选用0.1-0.5M盐酸或乳酸溶液，浸泡4小时后再用乳酸使动物皮变为半透明膨胀状，排去酸液，用清水洗涤3-4次。
所述步骤(4)中，油脂乳液按下述方法制得：将食用油脂加热成液体状，按食用油脂与水重量比1:1加入水，再加热，胶体磨乳化；所述食用油脂为氢化油脂、人造奶油或起酥油。
所述步骤(4)中，所述可食纤维素或可食纤维素衍生素的用量为动物皮重量的1-3％，油脂乳液为动物皮重量的1-5％，控制pH2.5-3.5，含水量为88-94％。
本发明所述面膜基材的形状可根据实际使用需求进行裁剪。例如，直接裁剪成目前市售最常用的整张面膜形状，并在眼、鼻、口相应部位开孔； 或者，将面膜基材裁成多个平面部分形成分段式面膜基材，如上下两部分、左右两部分，或更多部分；或者裁剪成立体3D结构，以方便不同脸部使用者根据脸部不同位置进行更有针对性的面部护理。
作为本发明优选实施方式之一，所述面膜基材为分段式面膜基材，以鼻子下部为分界线，将面部分为上半部分和下半部分，根据面部的上半部分和下半部分调整模具形状，再按照上述面膜基材的制备方法制得各部分面膜基材。具体如图1-4所示。
所述分段式面膜基材具体尺寸如下：面部上半部分面膜基材长度为230±5mm，宽度为102±5mm；其中，所述面部上半部分面膜基材中在眼部相应位置设有眼孔，眼孔为椭圆形，长轴为50±2mm，短轴为20±2mm；在面部上半部分面膜基材的下边缘设有六个开口，其中，两个开口设在下边缘近两端处，距离190±5mm；其余四个开口设在面膜基材鼻子部位的两侧，以方便使用者调整面膜基材使其更加服帖面部；其中设在面膜基材鼻子部位的两侧的开口呈对称布置，最远两个开口距离为60±2mm，中间两个开口距离为40±2mm。
面部下半部分面膜基材长度为230±5mm，宽度为100±5mm；其中对应鼻子部位设一缺口，宽度为45±2mm，避免面膜液影响使用者呼吸；面部下半部分面膜基材中唇部开孔为椭圆形，长轴为63±2mm，短轴为20±2mm，鼻子部位缺口下端距离唇部开孔上端距离为13±2mm；同样，面部下半部分面膜基材的下端也设有四个开口，以面部中轴为中轴线呈对称布置，最两端两个开口距离为125±2mm，中间两个开口距离为63±2mm。
作为本发明优选实施方式之一，所述面膜基材为3D面膜基材，则可依据左脸、右脸及口鼻三角部位调整模具形状，再按照上述方法制得各部分面膜，利用胶原蛋白专用粘合剂将各部分面膜粘合起来，利用模具形状切割四周做成3D圆脸，从而得到3D胶原蛋白面膜基材。具体如图5-10所示。
作为本发明优选的实施方式之一，所述3D面膜基材分为左脸部分、右脸部分及口鼻三角部分三部分；其中，所述3D面膜基材的左脸部分长度为203±5mm，上端宽度为88±5mm，下端宽度为106±5mm；眼部开孔为椭圆形，长轴为46±2mm，短轴为19±2mm；右脸部分与左脸部分为镜像结构；
而所述3D面膜基材的口鼻三角部分呈中间高两边低的立体结构，中间棱长度为109±5mm，左右两端到中间棱的距离为48±2mm；在所述所述3D面膜基材的口鼻三角部分对应鼻尖处和唇部位置设有鼻孔和唇孔，将中间棱分为五段，依次为20±2mm，13±2mm，13±2mm，20±2mm，43±2mm；鼻孔的最远端距离中间棱26±2mm，唇孔的最远端距离中间棱35±2mm.
本发明还提供一种面膜，由上述生物胶原蛋白面膜基材和面膜液组成。
所述面膜液由如下重量份的组分组成：水80.0-90.0份，1,3-丙二醇1.0-5.0份，甘油1.0-5.0份，甲基硅烷醇羟脯氨酸酯天冬氨酸酯0.05-3.0份，水解霍霍巴酯类0.01-1.0份，透明质酸钠0.1-2.0份，母菊(CHAMOMILLARECUTITA)提取物0.1-2.0份，糖蛋白0.1-1.0份，库拉索芦荟(ALOEBARBADENSIS)叶提取物0.2-3.0份，积雪草(CENTELLAASIATICA)提取物0.1-1.0份，粉防己(STEPHANIATETRANDRA)提取物0.1-1.0份，泛醌0.1-0.8份，澳洲坚果(MACADAMIATERNIFOLIA)籽油0.1-0.8份，PEG/PPG/聚丁二醇-8/5/3甘油0.1-1.0份，对羟基苯乙酮0.3-0.6份，丁二醇0.1-3.0份，1,2-己二醇0.4-2.0份，黄原胶0.1-1.0份，玫瑰(ROSARUGOSA)花油0.01-0.05份，PEG-40氢化蓖麻油0.5-0.8份，PPG-26-丁醇聚醚-26 0.5-0.8份。
作为本发明优选的实施方式之一，所述面膜液由如下重量份的组分组成：水85-88份，1,3-丙二醇4-5份，甘油3-5份，甲基硅烷醇羟脯氨酸酯天冬氨酸酯0.1-0.2份，水解霍霍巴酯类0.01-0.02份，透明质酸钠 0.1-0.15份，母菊(CHAMOMILLARECUTITA)提取物0.1-0.15份，糖蛋白0.1-0.15份，库拉索芦荟(ALOEBARBADENSIS)叶提取物0.2-0.25份，积雪草(CENTELLAASIATICA)提取物0.1-0.15份，粉防己(STEPHANIATETRANDRA)提取物0.1-0.15份，泛醌0.1-0.15份，澳洲坚果(MACADAMIATERNIFOLIA)籽油0.1-0.15份，PEG/PPG/聚丁二醇-8/5/3甘油0.4-0.6份，对羟基苯乙酮0.5-0.6份，丁二醇0.1-0.15份，1,2-己二醇0.4-0.5份，黄原胶0.5-0.7份，玫瑰(ROSARUGOSA)花油0.01-0.02份，PEG-40氢化蓖麻油0.7-0.8份，PPG-26-丁醇聚醚-26 0.7-0.8份。
本发明所述技术方案的有益效果：
本发明以生物胶原蛋白为原料，独创性将其制成面膜基材，成功取代现有无纺布类面膜基材存在的过敏等问题。采用本发明所述的面膜基材，渗透性好，天然无刺激，利用其独特的结构特点和与皮肤完美的贴合能力，可将精华液更好的渗入皮肤内，不反吸收，无残留，高效保湿，令面膜护肤精华成分吸收更彻底。
附图说明
图1为实施例1胶原蛋白膜片整体示意图。
图2为实施例1胶原蛋白膜片整体尺寸图。
图3为实施例1中上脸型胶原蛋白膜片尺寸图。
图4为实施例1中下脸型胶原蛋白膜片尺寸图。
图5为实施例2所述3D胶原蛋白膜片面膜立体图。
图6为实施例2所述面膜的整脸胶原蛋白膜片平面图.
图7为实施例2所述面膜的上脸部位胶原蛋白膜片图。
图8为实施例2所述面膜的口鼻三角部位胶原蛋白膜片图。
图9为实施例2所述面膜的左脸胶原蛋白膜片图。
图10为实施例2所述面膜的右脸胶原蛋白膜片图。
具体实施方式
以下实施例用于说明本发明，但不用来限制本发明的范围。
实施例1：分段式面膜
包括如下步骤：
(一)面膜液的配制：
水15.7212g，1,3-丙二醇0.9g，甘油0.54g，甲基硅烷醇羟脯氨酸酯天冬氨酸酯0.018g，水解霍霍巴酯类0.0018g，透明质酸钠0.0252g，母菊提取物0.018g，糖蛋白0.018g，库拉索芦荟叶提取物0.036g，积雪草提取物0.018g，粉防己提取物0.018g，泛醌0.018g，澳洲坚果籽油0.018g，PEG/PPG/聚丁二醇-8/5/3甘油0.09g，对羟基苯乙酮0.09g，丁二醇0.018g，1,2-己二醇0.072g，黄原胶0.108份，玫瑰花油0.0018g，PEG-40氢化蓖麻油0.135g，PPG-26-丁醇聚醚0.135g。
(二)分段式面膜基材的制备
工作环境要求：在10万级GMP洁净厂房内
温度要求：控制在22-26℃
相对湿度要求：控制在45％-55％
1、长230mm×宽102mm上脸型胶原蛋白膜片的制备步骤：
1)、按照CN100548127C中所述的方法得到生物胶原蛋白，将生物胶原蛋白置入挤压机，得到管状生物胶原蛋白膜，将直径52-54mm管状胶原蛋白膜放置在管状开边机的固定支架的滑轮轴上固定。
2)、用切刀机将管状胶原蛋白膜切割开边，经过褶皱压平轴装置压平。
3)、把压平的胶原蛋白膜延长拉伸到面膜成型切片机的滚轮上，使用定制的上脸的模具压在滚轮上，用手轮调整上脸的模具与滚轮的最小距离，利用电机旋转带动模具切刀压力把胶原蛋白膜切断,得到上脸胶原蛋白膜片。
2、长230mm×宽100mm下脸型胶原蛋白膜片的制备步骤：
4)、将直径52-54mm管状胶原蛋白膜放置在管状开边机的固定支架的滑轮轴上固定。
5)、用切刀机将管状胶原蛋白膜切割开边，经过褶皱压平轴装置压平。
6)、把压平的胶原蛋白膜延长拉伸到面膜成型切片机的滚轮上，使用定制的下脸的模具压在滚轮上，用手轮调整下脸的模具与滚轮的最小距离，利用电机旋转带动模具切刀压力把胶原蛋白膜切断,得到下脸胶原蛋白膜片。
3、生产时上脸、下脸各一片为一套，使用时分别敷贴成脸型即可。
所得面膜如图1-图4所示。
实施例2：3D胶原蛋白面膜
包括如下步骤：
(一)面膜液的配制：同实施例1所述面膜液配方。
(二)3D胶原蛋白面膜制作步骤：
工作环境要求：在10万级GMP洁净厂房内
温度要求：控制在22-26℃
相对湿度要求：控制在45％-55％
1、按照CN100548127C中所述的方法得到生物胶原蛋白，将生物胶原蛋白置入挤压机，得到管状生物胶原蛋白膜，将直径52-54mm管状胶原蛋白膜放置在管状开边机的固定支架的滑轮轴上固定。
2、用切刀机将管状胶原蛋白膜切割开边，经过褶皱压平轴装置压平。
3、把压平的胶原蛋白膜延长拉伸到面膜成型切片机的滚轮上，使用定制的左脸模具压在滚轮上，开好边及压平好的胶原蛋白卷膜夹在中间，用手轮调整上脸的模具与滚轮的最小距离，利用电机旋转带动模具切刀压力把胶原蛋白膜切断,得到左脸胶原蛋白膜片。
4、使用上述方法更换右脸的模具，得到右脸胶原蛋白膜片。
5、使用上述方法更换口鼻三角部位模具，得到口鼻三角部位胶原蛋白膜片。
6、将左脸胶原蛋白膜片、口鼻三角部位胶原蛋白膜片、右脸胶原蛋白膜片，用胶原蛋白专用粘合剂粘合起来，利用模具形状切割四周做成 3D圆脸，得到3D胶原蛋白面膜。
所得3D面膜基材如图5-10所示。
虽然，上文中已经用一般性说明及具体实施方案对本发明作了详尽的描述，但在本发明基础上，可以对之作一些修改或改进，这对本领域技术人员而言是显而易见的。因此，在不偏离本发明精神的基础上所做的这些修改或改进，均属于本发明要求保护的范围。
工业实用性
本发明提供一种生物胶原蛋白面膜基材。本发明所述生物胶原蛋白面膜基材通过以下方法制得：S1：将生物胶原蛋白置入挤压机，得到管状生物胶原蛋白膜，对管状生物胶原蛋白膜切割，压平；S2：将压平的胶原蛋白膜延长拉伸到面膜成型切片机的滚轮上，使用定制的模具压在滚轮上，用手轮调整模具与滚轮的最小距离，利用电机旋转带动模具切刀压力把胶原蛋白膜切断，得到胶原蛋白膜片。本发明提供的生物胶原蛋白面膜基材天然无刺激，渗透性好，使用安全，杜绝化工原料对肌肤的侵害，各类肌肤包括过敏性肌肤均可放心使用；并且该面膜基材利用其独特的结构特点和与皮肤完美的贴合能力，可将精华液更好的渗入皮肤内，不反吸收，无残留，高效保湿，令面膜护肤精华成分吸收更彻底，具有较好的经济价值和应用前景。

Claims (10)

  1. 一种生物胶原蛋白面膜基材，其特征在于，由如下方法制备：
    S1：将生物胶原蛋白置入挤压机，得到管状生物胶原蛋白膜，对管状生物胶原蛋白膜切割，压平；
    S2：将压平的胶原蛋白膜延长拉伸到面膜成型切片机的滚轮上，使用定制的模具压在滚轮上，用手轮调整模具与滚轮的最小距离，利用电机旋转带动模具切刀压力把胶原蛋白膜切断，得到胶原蛋白膜片；
    其中，步骤(1)中，所述生物胶原蛋白是从动物皮中提取得到的，具体方法为：
    (1)将动物皮清洗、分割；
    (2)分割的动物皮碱处理后，按动物皮与水重量比1:1加入水，用蛋白酶进行酶处理，所述蛋白酶加入量为动物皮重量的0.5-2％，在25-35℃下处理3-6小时，清洗后进行酸处理；
    (3)酸处理后的动物皮冷却至10℃以下，使用切粒、压片、斩拌、研磨方式或其组合方式切碎，碾压成片，通过高压过滤提取丝质纤维；
    (4)边搅拌边加入可食纤维素或可食纤维素衍生素、油脂乳液，控制pH值和含水量，混合搅拌均匀，得到生物胶原蛋白。
  2. 根据权利要求1所述的生物胶原蛋白面膜基材，其特征在于，所述步骤(2)中，所述蛋白酶为胃蛋白酶、木瓜蛋白酶或胰酶。
  3. 根据权利要求1所述的生物胶原蛋白面膜基材，其特征在于，所述步骤(2)中，所述碱处理为石灰乳腌制1-2天后用水冲洗干净；酸处理用0.1-0.5M盐酸或乳酸溶液，浸泡4小时后再用乳酸使动物皮呈现半透明膨胀状，排去酸液，用清水洗涤3-4次。
  4. 根据权利要求1所述的生物胶原蛋白面膜基材，其特征在于，所述步骤(4)中，所述可食纤维素或可食纤维素衍生素的用量为动物皮重量的1-3％，油脂乳液为动物皮重量的1-5％，控制pH2.5-3.5，含水量为88-94％。
  5. 根据权利要求1所述的生物胶原蛋白面膜基材，其特征在于，所述面膜基材的形状为平面整张面膜基材、分段式面膜基材、立体3D结构面膜基材。
  6. 根据权利要求5所述的生物胶原蛋白面膜基材，其特征在于，所述面膜基材为分段式面膜基材，其具体结构为：以鼻子下部为分界线将面部分为上半部分和下半部分；所述面部上半部分长度为230±5mm，宽度为102±5mm；所述面部下半部分面膜基材长度为230±5mm，宽度为100±5mm。
  7. 根据权利要求6所述的生物胶原蛋白面膜基材，其特征在于，所述面部上半部分面膜基材中在眼部相应位置设有椭圆形眼孔，其长轴为50±2mm，短轴为20±2mm；
    在面部上半部分面膜基材的下边缘设有六个开口，其中两个开口靠近面膜基材两端，间距为190±5mm，其余四个开口设在面膜基材鼻部两侧，且呈对称布置，最远两个开口距离为60±2mm，中间两个开口距离为40±2mm；
    所述面部下半部分面膜基材中对应鼻部处设一缺口，宽度为45±2mm；在所述面部下半部分面膜基材唇部对应位置开一椭圆形唇孔，长轴为63±2mm，短轴为20±2mm，鼻子部位缺口下端距离唇孔上端13±2mm；
    在面部下半部分面膜基材的下端设有四个以面部中轴为中轴线呈对称布置的开口，其中最两端开口间距为125±2mm，中间两个开口间距为63±2mm。
  8. 根据权利要求5所述的生物胶原蛋白面膜基材，其特征在于，所述面膜基材为3D面膜基材，分为左脸部分、右脸部分及口鼻三角部分三部分；
    其中，所述3D面膜基材的左脸部分长度为203±5mm，上端宽度为88±5mm，下端宽度为106±5mm；眼部开孔为椭圆形，长轴为46±2mm， 短轴为19±2mm；右脸部分与左脸部分为镜像结构；
    所述3D面膜基材的口鼻三角部分呈中间高两边低的立体结构，中间棱长度为109±5mm，左右两端到中间棱的距离为48±2mm；在所述3D面膜基材的口鼻三角部分对应鼻尖处和唇部位置设有鼻孔和唇孔，将中间棱分为五段，依次为20±2mm，13±2mm，13±2mm，20±2mm，43±2mm；鼻孔的最远端距离中间棱26±2mm，唇孔的最远端距离中间棱35±2mm。
  9. 一种面膜，其特征在于，由权利要求1-8任一所述生物胶原蛋白面膜基材和面膜液组成。
  10. 根据权利要求9所述的面膜，其特征在于，所述面膜液由如下重量份的组分组成：水80.0-90.0份，1,3-丙二醇1.0-5.0份，甘油1.0-5.0份，甲基硅烷醇羟脯氨酸酯天冬氨酸酯0.05-3.0份，水解霍霍巴酯类0.01-1.0份，透明质酸钠0.1-2.0份，母菊提取物0.1-2.0份，糖蛋白0.1-1.0份，库拉索芦荟叶提取物0.2-3.0份，积雪草提取物0.1-1.0份，粉防己提取物0.1-1.0份，泛醌0.1-0.8份，澳洲坚果籽油0.1-0.8份，PEG/PPG/聚丁二醇-8/5/3甘油0.1-1.0份，对羟基苯乙酮0.3-0.6份，丁二醇0.1-3.0份，1,2-己二醇0.4-2.0份，黄原胶0.1-1.0份，玫瑰花油0.01-0.05份，PEG-40氢化蓖麻油0.5-0.8份，PPG-26-丁醇聚醚-26 0.5-0.8份。
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Publication number Priority date Publication date Assignee Title
CN106974838A (zh) * 2017-04-13 2017-07-25 梧州神冠蛋白肠衣有限公司 一种生物胶原蛋白面膜基材及其应用
CN109381415A (zh) * 2017-08-10 2019-02-26 南通盈安纳米科技有限公司 一种能够激活人体细胞活血化瘀的护肤产品配方
CN108078820A (zh) * 2018-01-04 2018-05-29 湖北瑞晟生物有限责任公司 一种易吸收的玫瑰精油面膜
CN108524385A (zh) * 2018-03-27 2018-09-14 赵金椿 一种虾青素多效精华液及其制备方法
CN109010084A (zh) * 2018-10-20 2018-12-18 马建成 一种真皮面膜
CN110507548A (zh) * 2019-09-28 2019-11-29 广州香枝化妆品有限公司 一种高分子3d无痕超浸透紧致面膜及其制备方法
CN110664633A (zh) * 2019-11-16 2020-01-10 烟台东方化学有限公司 一种防腐增效组合物及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1861801A (zh) * 2006-04-10 2006-11-15 四川师范大学 胶原蛋白保湿面膜及其制备方法
CN106974838A (zh) * 2017-04-13 2017-07-25 梧州神冠蛋白肠衣有限公司 一种生物胶原蛋白面膜基材及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1219505C (zh) * 2002-05-08 2005-09-21 广东欧瑞卡生物工程有限公司 胶原蛋白面膜纸及其制备方法
CN1470640A (zh) * 2003-06-25 2004-01-28 暨南大学 一种胶原蛋白粉及其制备方法与应用
CN100548127C (zh) * 2008-07-09 2009-10-14 梧州神冠蛋白肠衣有限公司 中小口径胶原蛋白肠衣及其制备方法
CN105145781A (zh) * 2015-08-06 2015-12-16 梧州神冠蛋白肠衣有限公司 胶原蛋白肠衣的制备方法
CN105104493A (zh) * 2015-08-06 2015-12-02 梧州神冠蛋白肠衣有限公司 一种胶原蛋白肠衣的制备方法
CN106606463A (zh) * 2015-10-20 2017-05-03 青岛力天宏泰新能源科技有限公司 一种胶原蛋白抗衰老面膜
CN105193635B (zh) * 2015-10-23 2016-12-07 陈军山 一种凝胶美容贴膜制作装置、制作方法和凝胶美容贴膜

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1861801A (zh) * 2006-04-10 2006-11-15 四川师范大学 胶原蛋白保湿面膜及其制备方法
CN106974838A (zh) * 2017-04-13 2017-07-25 梧州神冠蛋白肠衣有限公司 一种生物胶原蛋白面膜基材及其应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Domestic Non-Special Use Cosmetics Record Electronic Certificates, Coll Full Bright Eyes Collagen Membrane Eye Mask, Record Number Gui G Cosmetics Approved Number 2016000423", INGREDIENTS, 19 September 2016 (2016-09-19), Retrieved from the Internet <URL:http://125.35.6.80:8080/ftba/itownet/hzp_ba/fw/pz.jsp?processid=20170519170340607ft&nid=20170519170340607ft> *

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