WO2018176686A1 - 辐射线照射系统及用于辐射线照射系统的定位组件 - Google Patents

辐射线照射系统及用于辐射线照射系统的定位组件 Download PDF

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Publication number
WO2018176686A1
WO2018176686A1 PCT/CN2017/092731 CN2017092731W WO2018176686A1 WO 2018176686 A1 WO2018176686 A1 WO 2018176686A1 CN 2017092731 W CN2017092731 W CN 2017092731W WO 2018176686 A1 WO2018176686 A1 WO 2018176686A1
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Prior art keywords
radiation
irradiated
shielding
irradiated body
neutron
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PCT/CN2017/092731
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English (en)
French (fr)
Inventor
萧明城
Original Assignee
南京中硼联康医疗科技有限公司
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Priority claimed from CN201710195539.0A external-priority patent/CN108653935B/zh
Application filed by 南京中硼联康医疗科技有限公司 filed Critical 南京中硼联康医疗科技有限公司
Priority to JP2019556397A priority Critical patent/JP6833064B2/ja
Priority to EP17902869.1A priority patent/EP3527261B1/en
Publication of WO2018176686A1 publication Critical patent/WO2018176686A1/zh
Priority to US16/412,792 priority patent/US11338155B2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1077—Beam delivery systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/103—Treatment planning systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/10—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis
    • A61B90/14—Fixators for body parts, e.g. skull clamps; Constructional details of fixators, e.g. pins
    • A61B90/18—Retaining sheets, e.g. immobilising masks made from a thermoplastic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61G—TRANSPORT, PERSONAL CONVEYANCES, OR ACCOMMODATION SPECIALLY ADAPTED FOR PATIENTS OR DISABLED PERSONS; OPERATING TABLES OR CHAIRS; CHAIRS FOR DENTISTRY; FUNERAL DEVICES
    • A61G13/00—Operating tables; Auxiliary appliances therefor
    • A61G13/02—Adjustable operating tables; Controls therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61G—TRANSPORT, PERSONAL CONVEYANCES, OR ACCOMMODATION SPECIALLY ADAPTED FOR PATIENTS OR DISABLED PERSONS; OPERATING TABLES OR CHAIRS; CHAIRS FOR DENTISTRY; FUNERAL DEVICES
    • A61G13/00—Operating tables; Auxiliary appliances therefor
    • A61G13/10—Parts, details or accessories
    • A61G13/12—Rests specially adapted therefor; Arrangements of patient-supporting surfaces
    • A61G13/126—Rests specially adapted therefor; Arrangements of patient-supporting surfaces with specific supporting surface
    • A61G13/1275—Rests specially adapted therefor; Arrangements of patient-supporting surfaces with specific supporting surface having air-evacuated chambers in order to adapt to the form of the patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
    • G21F1/00—Shielding characterised by the composition of the materials
    • G21F1/02—Selection of uniform shielding materials
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
    • G21F1/00—Shielding characterised by the composition of the materials
    • G21F1/02—Selection of uniform shielding materials
    • G21F1/10—Organic substances; Dispersions in organic carriers
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
    • G21F3/00—Shielding characterised by its physical form, e.g. granules, or shape of the material
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
    • G21K1/00—Arrangements for handling particles or ionising radiation, e.g. focusing or moderating
    • G21K1/10—Scattering devices; Absorbing devices; Ionising radiation filters
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H3/00—Production or acceleration of neutral particle beams, e.g. molecular or atomic beams
    • H05H3/06—Generating neutron beams
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H6/00—Targets for producing nuclear reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/04—Protection of tissue around surgical sites against effects of non-mechanical surgery, e.g. laser surgery
    • A61B2090/0409—Specification of type of protection measures
    • A61B2090/0436—Shielding
    • A61B2090/0445—Shielding by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/10—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis
    • A61B2090/101—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis for stereotaxic radiosurgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61G—TRANSPORT, PERSONAL CONVEYANCES, OR ACCOMMODATION SPECIALLY ADAPTED FOR PATIENTS OR DISABLED PERSONS; OPERATING TABLES OR CHAIRS; CHAIRS FOR DENTISTRY; FUNERAL DEVICES
    • A61G13/00—Operating tables; Auxiliary appliances therefor
    • A61G13/0018—Physician's examining tables
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61G—TRANSPORT, PERSONAL CONVEYANCES, OR ACCOMMODATION SPECIALLY ADAPTED FOR PATIENTS OR DISABLED PERSONS; OPERATING TABLES OR CHAIRS; CHAIRS FOR DENTISTRY; FUNERAL DEVICES
    • A61G2210/00—Devices for specific treatment or diagnosis
    • A61G2210/50—Devices for specific treatment or diagnosis for radiography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
    • A61N2005/109—Neutrons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1094—Shielding, protecting against radiation
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H6/00—Targets for producing nuclear reactions
    • H05H2006/007—Radiation protection arrangements, e.g. screens

Definitions

  • the present invention relates to a radiation illumination system, and more particularly to a positioning assembly for a radiation illumination system.
  • the main protection targets are neutrons and X-rays and gamma rays in photons.
  • the neutron source is used to irradiate the tumor site of the patient on the treatment bed, regardless of whether the neutron source of the neutron capture treatment is from the nuclear reactor or the nuclear reaction of the accelerator charged particle and the neutron production part.
  • the radiation field is a mixed radiation field, that is, the beam contains low-energy to high-energy neutrons, photons, especially neutrons.
  • the radiation other than thermal neutrons is irradiated to the human body, it must be certain to the normal tissue of the human body.
  • the treatment bed is usually made of an alloy such as magnesium alloy or aluminum alloy, it is easily activated by neutron absorption after being irradiated by radiation, so whether it is for the patient on the treatment bed or after the treatment is over Health care workers who come into contact with the treatment bed are a big health hazard.
  • one aspect of the present invention provides a radiation irradiation system including a radiation irradiation device.
  • a treatment bed for transporting the irradiated body to the radiation irradiation device, wherein the treatment bed includes a mounting table for placing the object to be irradiated, a support portion for supporting the mounting table, and a mounting portion and a positioning assembly for positioning the irradiated body, the positioning assembly comprising a shielding body and a sealing bag for accommodating the shielding body, the shielding body comprising a polymer and a radiation shielding material capable of shielding the radiation, when When the positioning member is provided with the irradiated body, the positioning member is placed with the position of the irradiated body recessed to form a contour corresponding to the irradiated body to position the irradiated body.
  • the irradiated body is positioned by setting a positioning assembly to avoid a difference in therapeutic effect due to movement of the irradiated body during the irradiation treatment.
  • the shielding body is made of the silica gel, the radiation shielding material and the silicone curing agent.
  • the shielding body in the sealed bag is in the form of solid particles.
  • the positioning component is recessed with the shape of the disposed object to form an object to be irradiated by vacuuming the sealed bag.
  • a fixed part is also possible.
  • the radiation illumination system is a neutron capture treatment system
  • the radiation illumination device is a neutron capture treatment device
  • the radiation shielding material is a neutron capture material
  • the neutron capture treatment device includes a sub-generation unit, a beam shaping body, a beam exit, and a collimator, the beam shaping body including a retarding body and a reflector coated on the retarded outer circumference, the neutron generating unit being irradiated by the charged particle beam Neutron is generated, the retarding body decelerates the neutron generated from the neutron generating portion to a preset energy spectrum, and the reflector guides the deviated neutron back to increase the neutron intensity within the preset energy spectrum.
  • the collimator is adjacent to the outside of the beam exit to concentrate a neutron beam emerging from the beam exit, the neutron capture material being capable of shielding neutrons from a boron containing compound or Made of at least one of lithium-containing compounds.
  • the boron-containing compound or the lithium-containing compound accounts for 10% to 49% by weight of the neutron capture material, and further, the boron-containing compound is 10 B 4 C or 10 BN, and the lithium-containing compound is LiF or 6 LiF, further, as a preferred, the neutron capture material further includes Li, C, O, Si and Br.
  • the treatment bed is further provided with an upper surface of the mounting table and a positioning component.
  • An auxiliary member between the lower surfaces, the auxiliary member being made of a carbon fiber material, and the positioning assembly is placed on the auxiliary member.
  • the mounting table and the support portion are made of an alloy material, and the surfaces of the mounting table and the support portion are covered with a shield portion, and the shield portion is made of the same material as the shield body in the positioning assembly.
  • the shielding portion covers the surface of the mounting table and the supporting portion to prevent an activation reaction of the alloy material after being irradiated by the neutron, thereby causing a hidden danger to the health of the irradiated body or the medical staff who will come into contact with the treatment bed.
  • one aspect of the present invention provides a positioning assembly for a radiation irradiation system, the positioning assembly including shielding And a sealing bag for accommodating the shielding body, the shielding body comprises a polymer shielding material and a radiation shielding material capable of shielding the radiation, the positioning component is illuminated when the positioning component is provided with the irradiated body
  • the position of the body is recessed with the shape of the irradiated body to form a contour corresponding to the irradiated body to position the irradiated body.
  • the irradiated body is positioned by setting a positioning assembly to avoid a difference in therapeutic effect due to movement of the irradiated body during the irradiation treatment.
  • the shielding body is made of the silica gel, the radiation shielding material and the silica gel curing agent, and the shielding body in the sealed bag is a plurality of solid particles.
  • the positioning component When the sealed bag is vacuumed, the positioning component has The position of the irradiated body is recessed to form a contour corresponding to the irradiated body to shape the irradiated body; when the irradiated body on the surface of the sealed bag is removed, and the sealed bag is filled with air, The positioning assembly is restored to a state before vacuuming.
  • one aspect of the present invention provides a radiation irradiation system including radiation.
  • an aspect of the invention provides a positioning assembly for a radiation illumination system, the radiation illumination system comprising a radiation illumination device and transporting the illuminated body to the radiation illumination device for illumination
  • the positioning assembly positions the irradiated body, the positioning assembly has a first state and a second state, and when the positioning component is in the first state, the positioning component is not deformed by external pressure or Maintaining in a first deformed state; when the positioning assembly is in the second state, the positioning assembly is deformed by external pressure or maintained in a second deformed state different from the first deformed state.
  • the first state of the positioning component includes two situations, one is a state in which the positioning component does not receive external pressure and is not deformed, and the other is a state in which the positioning component is deformed by external pressure (this application)
  • the second state includes two cases, one is a state in which the positioning component is deformed by external pressure (can be understood as the same condition as the first deformation state), and the other is a positioning component. A second deformation state that is different from the first deformation state by the external pressure.
  • the radiation irradiation system of the present application provides a positioning assembly capable of fixing the irradiated body to avoid a difference in the therapeutic effect due to the movement of the irradiated body during the irradiation treatment.
  • the positioning component is used to shield the radiation to avoid radiation damage to the irradiated body other than the radiation treatment during the radiation irradiation treatment.
  • Figure 1 is a schematic illustration of a neutron capture therapy system of the present application
  • FIG. 2 is a schematic illustration of a treatment bed of the present application
  • Figure 3 is a cross-sectional view of the positioning assembly of the present application.
  • Figure 4 is a schematic view of the mounting table and the support member of the present application.
  • FIG. 5 is a schematic view showing a shielding body between a collimator and a metal foil to measure a neutron reaction rate
  • Figure 6 is a schematic illustration of the present application for setting PMMA between a collimator and a metal foil to measure the neutron reaction rate.
  • neutron capture therapy has been increasingly used as an effective means of treating cancer in recent years, with boron neutron capture therapy being the most common, and neutrons supplying boron neutron capture therapy can be supplied by nuclear reactors or accelerators.
  • the neutron source of the neutron capture treatment comes from the nuclear reaction of the nuclear reactor or the charged particles of the accelerator and the neutron generator.
  • the radiation field is the mixed radiation field, that is, the beam contains low-energy to high-energy neutrons and photons.
  • the more radiation content in addition to the superheated neutrons, the more radiation content, the greater the proportion of non-selective dose deposition in normal tissues, so these will cause unnecessary doses of radiation to be minimized. .
  • the present application provides a neutron capture treatment system 100 including a neutron capture treatment device 200 and capable of delivering an irradiated body to the neutron capture treatment device 200 for illumination.
  • the treated treatment bed 300 As shown in FIG. 1, the present application provides a neutron capture treatment system 100 including a neutron capture treatment device 200 and capable of delivering an irradiated body to the neutron capture treatment device 200 for illumination.
  • the treated treatment bed 300 As shown in FIG. 1, the present application provides a neutron capture treatment system 100 including a neutron capture treatment device 200 and capable of delivering an irradiated body to the neutron capture treatment device 200 for illumination.
  • the treated treatment bed 300 As shown in FIG. 1, the present application provides a neutron capture treatment system 100 including a neutron capture treatment device 200 and capable of delivering an irradiated body to the neutron capture treatment device 200 for illumination.
  • the treated treatment bed 300 As shown in FIG. 1, the present application provides a neutron capture treatment system 100 including a neutron capture treatment device 200 and capable of delivering
  • the neutron capture treatment device 200 includes a neutron production unit 10, a beam shaping body 20, a beam outlet 30, and a collimator 40.
  • the beam shaping body 20 includes a retarding body 21 and a reflector 22 coated on the outer periphery of the retarding body 21, and the neutron generating unit 10 generates a neutron N after being irradiated by the charged particle beam P, the retarding body 21 decelerating the neutron N generated from the neutron generating portion 10 to a preset energy spectrum, the reflector 22 directing the deviated neutrons to increase the neutron intensity within the preset energy spectrum, the collimator 40 Adjacent to the outside of the beam exit 30 to converge the neutron beam emerging from the beam exit 30.
  • the treatment table 300 includes a mounting table 50 on which an object to be irradiated, a support portion 51 for supporting the mounting table 50, and an upper surface provided on the mounting table 50, and the object to be irradiated Positioning component 52 for positioning.
  • the positioning assembly 52 includes a sealed bag 53 and a shield 54 received in the sealed bag 53.
  • the shield 54 is made of silica gel, a neutron capture material, and a silica gel curing agent. It may be replaced by other polymers, and the silica gel in the shielding body 54 is used as a substrate. Of course, the silica gel may be replaced by other polymer tapes, which will not be described in detail herein.
  • the neutron capture material is made of at least one of a boron-containing compound or a lithium-containing compound, and the boron-containing compound or lithium-containing compound accounts for 10% to 50% by weight of the neutron capture material. In this embodiment, the neutron capture material is selected from 10 BN, and the neutron capture material further includes Li, C, O, Si, and Br.
  • the shield 54 in the sealed bag 53 is a solid granular structure, and the sealed bag 53 is provided with a sealing port 55 for connecting to an external vacuuming device (not shown).
  • an external vacuuming device (not shown)
  • the solid particulate shielding body 54 in the sealed bag 53 is recessed by the gravity of the irradiated body to form the same shape as the contour of the irradiated body, and the pumping is used.
  • a vacuum device (not shown) evacuates the sealed bag 53, and the shape of the recessed portion of the positioning member 52 that is the same as the contour of the irradiated body is formed to enable positioning of the irradiated body.
  • the positioning assembly 52 can be restored to a state before the irradiated body is disposed before the positioning assembly 52. It can be seen that the positioning assembly 52 described in the present application can be reused and can be applied to irradiated bodies of different body types.
  • the solid particulate form refers to a solid having a maximum diameter of between 0.01 mm and 10 mm.
  • the shield can be made directly from the silica gel and the neutron capture material, in which case the shield is made of a flowable liquid of a certain viscosity.
  • the flowable shield is poured into the sealed bag 53.
  • the shield in the flowable state in the sealed bag 53 is recessed with the gravity of the irradiated body.
  • the shape of the irradiated body is the same, and the sealed bag 53 is evacuated by using the vacuuming device (not shown).
  • the shape of the recessed portion of the bit assembly 52 that is the same as the contour of the irradiated body enables positioning of the object to be irradiated.
  • the mounting table 50 and the support portion 51 are both made of an alloy material, and the surfaces of the mounting table 50 and the support portion 51 are covered with the mounting table 50 and the support portion 51.
  • the shield portion 54' herein is the same material as the solid particulate shield 54 in the sealed bag 53 of the positioning assembly 52 described above. That is, the shield portion 54' which is coated on the surface of the mounting table 50 and the support portion 51 is substantially the same as the shield 54 of the sealed bag 53, and is merely a difference in expression.
  • the shield portion 54' coated on the surface of the mounting table 50 and the support portion 51 has a thickness of not less than 1 cm.
  • the treatment couch 300 is also provided with an auxiliary member 60 between the upper surface of the mounting table 50 and the lower surface of the positioning assembly 52.
  • the auxiliary member 60 is made of a carbon fiber material, and the positioning assembly 52 is placed in the auxiliary member 60. on.
  • FIG. 5 and 6 are schematic views of detecting the shielding effect of the shield on the neutron ray.
  • a shield 54 is disposed between the collimator 40 and the metal foil 70; in Fig. 6, the shield 54 is replaced by PMMA (polymethyl methacrylate, which does not have any shielding effect on the neutron).
  • PMMA polymethyl methacrylate, which does not have any shielding effect on the neutron.
  • the size of the PMMA is exactly the same as the size of the shield 54.
  • the metal foil 70 and the detector 80 are used to detect the neutron capture material's shielding effect against neutron rays.
  • the metal foil 70 (such as a copper piece) is disposed on a surface of the shielding body 54 away from the side of the collimator 40 (the relative position of the collimator 40 is A), and the detector 80 is connected to The metal foil 70, the neutron capture treatment device 200 irradiates the metal foil 70 with a neutron beam, and detects the neutron beam through the shield 54 through the shield 54 for neutron shielding and then irradiates the metal foil.
  • the neutron reaction rate of the sheet 70 likewise, the metal foil sheet 70 is disposed on the surface of the PMMA away from the side of the collimator 40 (distance from the collimator position A), and the detector 80 is connected to the The metal foil 70, the neutron capture treatment device 200 illuminates the metal foil 70 with a neutron beam, and passes through the detector 80 to detect the neutron reaction rate of the metal foil 70 directly by the neutron beam.
  • RR indicates the neutron reaction rate of the neutron beam passing through the shield and irradiating it to the gold foil (such as copper);
  • RR ref is the direct irradiation of the neutron beam to the gold foil (such as copper)
  • the sub-reaction rate as can be seen from the ratio of RR to RR ref , the shield of the present application does have a good effect on the shielding of neutrons, and the smaller the ratio of RR to RR ref , the shielding of the neutron by the shield. The better the effect.
  • the 10 BN content described in Table 1 is only 10% to 49% by weight of the neutron capture material.
  • the 10 BN content accounts for 10% of the weight of the neutron capture material. ⁇ 100% (as shown in Figure 7), except that when the 10 BN content accounts for more than 49% of the weight of the neutron capture material, the shield's shielding ability against neutron rays and 10 BN content account for the neutron capture.
  • the weight of the material is 10% to 49%, the shielding effect of the shielding body on the neutron beam is not greatly improved.
  • the ratio of the 10 BN content to the weight of the neutron capturing material is preferably 10% to 49%. .
  • the metal foil 70 is relatively The position of the collimator 40 is the same.
  • the neutron capture treatment system and the neutron capture material for shielding neutrons are taken as an example for detailed description.
  • the technical solution in the present application can also be applied to other radiation irradiation systems, and the present application No more examples are given.
  • the radiation irradiation system disclosed in the present application is not limited to the contents described in the above embodiments and the structures shown in the drawings. Obvious modifications, substitutions, or alterations of the materials, shapes, and positions of the components in the present application are within the scope of the present disclosure.

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Abstract

辐射线照射系统包括辐射线照射装置及将被照射体运输至辐射线照射装置进行照射的治疗床（300），治疗床（300）具有定位组件（52），定位组件（52）包括屏蔽体（54）以及容置屏蔽体（54）的密封袋（53），屏蔽体（54）包括硅胶和能够对辐射线进行屏蔽的辐射线屏蔽材，当对密封袋（53）表面置有被照射体的定位组件（52）抽真空后，定位组件（52）置有被照射体的位置随着被照射体的形状凹陷形成与被照射体相同的轮廓以对被照射体进行定位。通过设置定位组件（52）对被照射体进行定位，以避免因被照射体在照射治疗过程中发生运动而导致治疗效果的差异，同时避免了在辐射线照射治疗过程中辐射线对被照射体需要进行辐射治疗以外的部位及医护人员造成辐射伤害。

Description

辐射线照射系统及用于辐射线照射系统的定位组件 技术领域
本发明涉及一种辐射线照射系统，尤其涉及一种用于辐射线照射系统的定位组件。
背景技术
随着核技术相关产业的快速发展，高能辐射射线已广泛应用于工业、医疗、科研等多个领域，由此带来的辐射安全与防护问题也越来越重要，主要防护对象是中子以及光子中的X射线以及γ射线。
尤其在医疗领域，以中子捕获治疗为例，是利用中子源对治疗床上的患者肿瘤部位进行照射，无论中子捕获治疗的中子源来自核反应堆或加速器带电粒子与中子产生部的核反应，产生辐射场的皆为混合辐射场，即射束包含了低能至高能的中子、光子，尤其是中子，当热中子以外的辐射线照射至人体时务必会对人体正常组织产生一定程度的伤害，并且因为治疗床通常是由如镁合金或者铝合金等合金材质制成，在受到辐射线照射后易吸收中子而被活化，因此无论是对治疗床上的患者还是对治疗结束后接触到治疗床的医护人员来说，都是很大的健康隐患。
发明内容
为了避免在辐射线照射治疗过程中辐射线对被照射体需要进行辐射治疗以外的部位造成辐射损伤，本发明的一个方面提供一种辐射线照射系统，所述辐射线照射系统包括辐射线照射装置及将被照射体运输至所述辐射线照射装置进行照射的治疗床，所述治疗床包括用于载置被照射体的载置台、用于支撑载置台的支撑部以及设于载置台并对被照射体进行定位的定位组件，所述定位组件包括屏蔽体以及容置所述屏蔽体的密封袋，所述屏蔽体包括聚合物以及能够对辐射线进行屏蔽的辐射线屏蔽材，当所述定位组件置有被照射体时，所述定位组件置有被照射体的位置随着被照射体的形状凹陷形成与所述被照射体相应的轮廓以对所述被照射体进行定位。通过设置定位组件对被照射体进行定位，以避免因被照射体在照射治疗过程中发生运动而导致治疗效果的差异。
进一步地，为了使定位组件针对不同体型的被照射体能够被重复使用，作为一种优选地，本申请中，所述屏蔽体由所述硅胶、辐射线屏蔽材以及硅胶固化剂制成，所述密封袋中的屏蔽体为固态颗粒状，当对密封袋抽真空后，所述定位组件置有被照射体的位置随着被照射体的形状凹陷形成与被照射体相应的轮廓以对所述被照射体进行定位；当密封袋表面的被照射体移除，密封袋中充有空气时，所述定位组件还原成抽真空前的状态。
当然，若将密封袋中的屏蔽体设置成液态(如不使用硅胶固化剂)，通过对密封袋抽真空来使定位组件随着设置的被照射体的形状凹陷形成对被照射体进行定位的固定部也是可以的。
进一步地，所述辐射线照射系统为中子捕获治疗系统，所述辐射线照射装置为中子捕获治疗装置，所述辐射线屏蔽材为中子捕获材料，所述中子捕获治疗装置包括中子产生部、射束整形体、射束出口以及准直器，所述射束整形体包括缓速体及包覆于缓速体外周的反射体，所述中子产生部经带电粒子束照射后产生中子，所述缓速体将自中子产生部产生的中子减速至预设能谱，所述反射体将偏离的中子导回以提高预设能谱内的中子强度，所述准直器邻接于所述射束出口外侧以汇聚从射束出口出来的中子射束，所述中子捕获材料能够对中子进行屏蔽，所述中子捕获材料由含硼化合物或者含锂化合物中的至少一种制成。
进一步地，所述含硼化合物或者含锂化合物占所述中子捕获材料重量的10％～49％，进一步地，所述含硼化合物为10B4C或者10BN，所述含锂化合物为LiF或者6LiF，进一步地，作为一种优选地，所述中子捕获材料中还包括Li、C、O、Si及Br。
进一步地，为了避免治疗床上的其他部件因辐射线照射后发生活化现象，对医护人员以及被照射体造成损害，作为一种优选地，所述治疗床还设有位于载置台上表面和定位组件下表面之间的辅助件，所述辅助件为碳纤维材料制成，所述定位组件置于所述辅助件上。同时，所述载置台和支撑部采用合金材料制成，所述载置台和支撑部的表面包覆有屏蔽部，所述屏蔽部与所述定位组件中的屏蔽体的材料相同。所述屏蔽部包覆于所述载置台和支撑部表面以避免合金材料被中子照射后发生活化反应，从而对会接触到治疗床的被照射体或者医护人员的健康带来隐患。
为了避免在辐射线照射治疗过程中辐射线对被照射体需要进行辐射治疗以外的部位造成辐射损伤，本发明的一个方面提供一种用于辐射线照射系统的定位组件，所述定位组件包括屏蔽体以及容置所述屏蔽体的密封袋，所述屏蔽体包括由聚合物以及能够对辐射线进行屏蔽的辐射线屏蔽材，当定位组件置有被照射体时，所述定位组件有被照射体的位置随着被照射体的形状凹陷形成与被照射体相应的轮廓以对所述被照射体进行定位。通过设置定位组件对被照射体进行定位，以避免因被照射体在照射治疗过程中发生运动而导致治疗效果的差异。
进一步地，所述屏蔽体由所述硅胶、辐射线屏蔽材以及硅胶固化剂制成，所述密封袋中的屏蔽体为若干固态颗粒状，当对密封袋抽真空后，所述定位组件有被照射体的位置随着被照射体的形状凹陷形成与被照射体相应的轮廓以对所述被照射体进行定位；当密封袋表面的被照射体移除，密封袋中充有空气时，所述定位组件还原成抽真空前的状态。
进一步地，为了避免在辐射线照射治疗过程中辐射线对被照射体需要进行辐射治疗以外的部位造成辐射损伤，本发明的一个方面提供一种辐射线照射系统，所述辐射线照射系统包括辐射线照射装置及将被照射体运输至所述辐射线照射装置进行照射的治疗床，所述治疗床包括用于载置被照射体的载置台、用于支撑载置台的支撑部以及设于载置台并对被照射体进行定位的定位组件，所述定位组件具有第一状态和第二状态，当所述定位组件处于第一状态时，所述定位组件未受外界压力而变形或保持在第一变形状态；当所述定位组件处于第二状态时，所述定位组件受到外界压力而变形或保持在不同于第一变形状态的第二变形状态。
进一步地，为了避免在辐射线照射治疗过程中辐射线对被照射体需要进行辐射治疗以外 的部位造成辐射损伤，本发明的一个方面提供一种用于辐射线照射系统的定位组件，所述辐射线照射系统包括辐射线照射装置及将被照射体运输至所述辐射线照射装置进行照射的治疗床，所述定位组件对被照射体进行定位，所述定位组件具有第一状态和第二状态，当所述定位组件处于第一状态时，所述定位组件未受外界压力而变形或保持在第一变形状态；当所述定位组件处于第二状态时，所述定位组件受到外界压力而变形或保持在不同于第一变形状态的第二变形状态。
本申请中，所述定位组件的第一状态包括两种情况，一种是定位组件未收到外界压力、未发生变形的状态，一种是定位组件受到外界压力而发生变形的状态(本申请中称之为第一变形状态)；第二状态包括两种情况，一种是定位组件受到外界压力而发生形变的状态(可以理解为与第一变形状态相同的情况)，一种是定位组件受到外界压力发生不同于第一变形状态的第二变形状态。
与现有技术相比，本申请辐射线照射系统通过设置能够对被照射体进行固定的定位组件，以避免因被照射体在照射治疗过程中发生运动而导致治疗效果的差异。同时，利用该定位组件对辐射线进行屏蔽，以避免在辐射线照射治疗过程中辐射线对被照射体需要进行辐射治疗以外的部位造成辐射损伤。
附图说明
图1是本申请中子捕获治疗系统的示意图；
图2是本申请所述治疗床的示意图；
图3是本申请所述定位组件的剖视图；
图4是本申请所述载置台和支撑件的示意图；
图5是本申请在准直器和金属箔片之间设置屏蔽体以测量中子反应率的示意图；
图6是本申请在准直器和金属箔片之间设置PMMA以测量中子反应率的示意图。
具体实施方式
随着核技术相关产业的快速发展，辐射线已广泛应用于工业、医疗、科研等多个领域，由此带来的辐射安全与防护问题也越来越重要，尤其在医疗领域，中子捕获治疗为例，中子捕获治疗作为一种有效的治疗癌症的手段近年来的应用逐渐增加，其中以硼中子捕获治疗最为常见，供应硼中子捕获治疗的中子可以由核反应堆或加速器供应。
无论中子捕获治疗的中子源来自核反应堆或加速器带电粒子与中子产生部的核反应，产生辐射场的皆为混合辐射场，即射束包含了低能至高能的中子、光子。对于深部肿瘤的硼中子捕获治疗，除了超热中子外，其余的辐射线含量越多，造成正常组织非选择性剂量沉积的比例越大，因此这些会造成不必要剂量的辐射应尽量降低。此外，这些辐射线照射至如镁合金或者铝合金等合金材料制成的治疗床时，合金材料会因辐射线的照射被活化，因此无论是对会接触到治疗床的患者还是对治疗结束后接触到治疗床的医护人员来说，都是很大的健康 隐患。
如图1所示，本申请提供一种中子捕获治疗系统100，所述中子捕获治疗系统包括中子捕获治疗装置200以及能够将被照射体输送至所述中子捕获治疗装置200进行照射治疗的治疗床300。
所述中子捕获治疗装置200包括中子产生部10、射束整形体20、射束出口30以及准直器40。所述射束整形体20包括缓速体21及包覆于缓速体21外周的反射体22，所述中子产生部10经带电粒子束P照射后产生中子N，所述缓速体21将自中子产生部10产生的中子N减速至预设能谱，所述反射体22将偏离的中子导回以提高预设能谱内的中子强度，所述准直器40邻接于所述射束出口30的外侧以汇聚从射束出口30出来的中子射束。
如图2所示，所述治疗床300包括用于载置被照射体的载置台50、用于支撑载置台50的支撑部51以及设于载置台50上表面并且能够对所述被照射体进行定位的定位组件52。
结合图3，所述定位组件52包括密封袋53以及容置在所述密封袋53中的屏蔽体54，所述屏蔽体54由硅胶、中子捕获材料以及硅胶固化剂制成，所述硅胶可以也可以由其他聚合物代替，并且，所述屏蔽体54中的硅胶是用来作为基底使用的，当然所述硅胶也可以采用其他聚合物带替代，此处就不再举例详细说明。所述中子捕获材料由含硼化合物或者含锂化合物中的至少一种制成，所述含硼化合物或者含锂化合物占所述中子捕获材料重量的10％～50％。本实施方式中，所述中子捕获材料选用的是10BN，并且所述中子捕获材料中还包括Li、C、O、Si及Br。
所述密封袋53中的屏蔽体54为固态颗粒状结构，所述密封袋53设有密封口55，所述密封口55用于连接至外部的抽真空装置(未图示)。当被照射体置于所述定位组件52后，所述密封袋53内的固态颗粒状的屏蔽体54因被照射体的重力凹陷形成与所述被照射体轮廓相同的形状，使用所述抽真空装置(未图示)对所述密封袋53抽真空，所述定位组件52上凹陷的与所述被照射体轮廓相同的形状形成能够对所述被照射体进行定位。当密封袋53内不再是真空状态时，所述定位组件52可以恢复至被照射体设置于定位组件52之前的状态。由此可见，本申请中所述定位组件52可以重复使用，并且能够适用于不同体型的被照射体。
本申请中，所述固态颗粒状是指最大直径处于在0.01毫米至10毫米之间的固体。
当然，可以直接用硅胶和中子捕获材料制成屏蔽体，这种情况下制成的屏蔽体为具有一定粘稠度的可流动的液体。将所述可流动状态的屏蔽体灌注于所述密封袋53中，当被照射体置于定位组件52后，密封袋53内可流动状态的屏蔽体随着被照射体的重力凹陷形成与所述被照射体轮廓相同的形状，使用所述抽真空装置(未图示)对所述密封袋53抽真空，所述定 位组件52上凹陷的与所述被照射体轮廓相同的形状能够对所述被照射体进行定位。
结合图4，本申请中，所述载置台50和支撑部51均采用合金材料制成，所述载置台50和支撑部51的表面均包覆有能够避免所述载置台50和支撑部51被中子射束照射后发生活化的屏蔽部54’。此处所述屏蔽部54’与前文所述定位组件52的密封袋53中的固态颗粒状的屏蔽体54的材料相同。也就是说，包覆在所述载置台50和支撑部51表面的屏蔽部54’与密封袋53被的屏蔽体54的实质相同，仅仅只是表现形态上的不同。所述包覆在所述载置台50和支撑部51表面的屏蔽部54’的厚度不少于1公分。
所述治疗床300还设有位于载置台50上表面和定位组件52下表面之间的辅助件60，所述辅助件60由碳纤维材料制成，所述定位组件52置于所述辅助件60上。
图5和图6为检测屏蔽体对中子射线屏蔽效果的示意图。图5中，在准直器40和金属箔片70之间设置屏蔽体54；图6中，用PMMA(聚甲基丙烯酸甲酯，对中子没有任何屏蔽效果)代替屏蔽体54，所述PMMA的尺寸与屏蔽体54的尺寸完全一致。本申请中，用金属箔片70和侦检器80来检测中子捕获材料对中子射线屏蔽效果。具体为，将所述金属箔片70(如铜片)设置在屏蔽体54远离准直器40一侧的表面(距离准直器40相对位置为A处)，所述侦检器80连接于所述金属箔片70，中子捕获治疗装置200对所述金属箔片70照射中子射束，通过侦检器80检测中子射束经过屏蔽体54进行中子屏蔽后再照射至金属箔片70的中子反应率；同样地，将金属箔片70设置在PMMA远离准直器40一侧的表面(距离准直器相对位置为A处)，所述侦检器80连接于所述金属箔片70，中子捕获治疗装置200对所述金属箔片70照射中子射束，通过侦检器80以检测中子射束直接照射金属箔片70的中子反应率。
表一：不同材料比例下的屏蔽体对中子射线的屏蔽效果
Figure PCTCN2017092731-appb-000001
表一中，RR表示中子射束经过所述屏蔽体后照射至金箔片(如铜片)的中子反应率；RRref为中子射束直接照射至金箔片(如铜片)的中子反应率，由RR与RRref比值可以看出，本申请所述屏蔽体对中子的屏蔽确实有着很好的效果，并且，RR与RRref的比值越小，屏蔽体对中子的屏蔽效果越好。
当然，表一中记载的10BN含量占所述中子捕获材料重量的10％～49％只是优选的实施方式，在实际制造过程中，10BN含量占所述中子捕获材料重量的10％～100％(如图7所示)，只是， 当10BN含量占所述中子捕获材料重量的49％以上时，屏蔽体对中子射线的屏蔽能力与10BN含量占所述中子捕获材料重量的10％～49％时屏蔽体对中子射线的屏蔽效果并没有很大提升，出于制造成本的考量，10BN含量占所述中子捕获材料重量的比例优选10％～49％。
需要注意的是，为了保证测量的准确性，在使用金属箔片70检测中子反应率RR(设置屏蔽体54)及RRref(未设置屏蔽体54)过程中，所述金属箔片70相对于准直器40的位置相同。
当然，本申请中是以所述中子捕获治疗系统以及用于屏蔽中子的中子捕获材料为例进行详细说明，本申请中技术方案也可应用于其他辐射线照射系统中，本申请就不再一一举例说明。
另，本申请揭示的用于辐射线照射系统并不局限于以上实施例所述的内容以及附图所表示的结构。在本申请的基础上对其中构件的材料、形状及位置所做的显而易见地改变、替代或者修改，都在本申请要求保护的范围之内。

Claims (10)

  1. 一种辐射线照射系统，所述辐射线照射系统包括辐射线照射装置及将被照射体运输至所述辐射线照射装置进行照射的治疗床，其特征在于：所述治疗床包括用于载置被照射体的载置台、用于支撑载置台的支撑部以及设于载置台并对被照射体进行定位的定位组件，所述定位组件包括屏蔽体以及容置所述屏蔽体的密封袋，所述屏蔽体包括聚合物以及能够对辐射线进行屏蔽的辐射线屏蔽材，当所述定位组件置有被照射体时，所述定位组件置有被照射体的位置随着被照射体的形状凹陷形成与所述被照射体相应的轮廓以对所述被照射体进行定位。
  2. 根据权利要求1所述的辐射线照射系统，其特征在于：所述屏蔽体由所述硅胶、辐射线屏蔽材以及硅胶固化剂制成，所述密封袋中的屏蔽体为固态颗粒状，当对密封袋抽真空后，所述定位组件置有被照射体的位置随着被照射体的形状凹陷形成与被照射体相应的轮廓以对所述被照射体进行定位；当密封袋表面的被照射体移除，密封袋中充有空气时，所述定位组件还原成抽真空前的状态。
  3. 根据权利要求1所述的辐射线照射系统，其特征在于：所述辐射线照射系统为中子捕获治疗系统，所述辐射线照射装置为中子捕获治疗装置，所述辐射线屏蔽材为中子捕获材料，所述中子捕获治疗装置包括中子产生部、射束整形体、射束出口以及准直器，所述射束整形体包括缓速体及包覆于缓速体外周的反射体，所述中子产生部经带电粒子束照射后产生中子，所述缓速体将自中子产生部产生的中子减速至预设能谱，所述反射体将偏离的中子导回以提高预设能谱内的中子强度，所述准直器邻接于所述射束出口外侧以汇聚从射束出口出来的中子射束，所述中子捕获材料能够对中子进行屏蔽，所述中子捕获材料由含硼化合物或者含锂化合物中的至少一种制成。
  4. 根据权利要求3所述的辐射线照射系统，其特征在于：所述含硼化合物或者含锂化合物占所述中子捕获材料重量的10％～49％，所述含硼化合物为10B4C或者10BN，所述含锂化合物为LiF或者6LiF，所述中子捕获材料中还包括Li、C、O、Si及Br。
  5. 根据权利要求2至4中任一项所述的辐射线照射系统，其特征在于：所述载置台和支撑部采用合金材料制成，所述载置台和支撑部的表面包覆有屏蔽部，所述屏蔽部与所述定位组件中的屏蔽体的材料相同。
  6. 根据权利要求1所述的辐射线照射系统，其特征在于：所述治疗床还设有位于载置台上表面和定位组件下表面之间的辅助件，所述辅助件为碳纤维材料制成，所述定位组件置于所述辅助件上。
  7. 一种用于辐射线照射系统的定位组件，其特征在于，所述定位组件包括屏蔽体以及容置所述屏蔽体的密封袋，所述屏蔽体包括由聚合物以及能够对辐射线进行屏蔽的辐射线屏蔽材，当定位组件置有被照射体时，所述定位组件有被照射体的位置随着被照射体的形状凹陷形成与被照射体相应的轮廓以对所述被照射体进行定位。
  8. 根据权利要求7所述的用于辐射线照射系统的定位组件，其特征在于：所述屏蔽体由所述硅胶、辐射线屏蔽材以及硅胶固化剂制成，所述密封袋中的屏蔽体为若干固态颗粒状，当 对密封袋抽真空后，所述定位组件有被照射体的位置随着被照射体的形状凹陷形成与被照射体相应的轮廓以对所述被照射体进行定位；当密封袋表面的被照射体移除，密封袋中充有空气时，所述定位组件还原成抽真空前的状态。
  9. 一种辐射线照射系统，所述辐射线照射系统包括辐射线照射装置及将被照射体运输至所述辐射线照射装置进行照射的治疗床，其特征在于：所述治疗床包括用于载置被照射体的载置台、用于支撑载置台的支撑部以及设于载置台并对被照射体进行定位的定位组件，所述定位组件具有第一状态和第二状态，当所述定位组件处于第一状态时，所述定位组件未受外界压力而变形或保持在第一变形状态；当所述定位组件处于第二状态时，所述定位组件受到外界压力而变形或保持在不同于第一变形状态的第二变形状态。
  10. 一种用于辐射线照射系统的定位组件，所述辐射线照射系统包括辐射线照射装置及将被照射体运输至所述辐射线照射装置进行照射的治疗床，其特征在于，所述定位组件对被照射体进行定位，所述定位组件具有第一状态和第二状态，当所述定位组件处于第一状态时，所述定位组件未受外界压力而变形或保持在第一变形状态；当所述定位组件处于第二状态时，所述定位组件受到外界压力而变形或保持在不同于第一变形状态的第二变形状态。
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