WO2018106191A1 - Matériau d'emballage et son procédé de préparation - Google Patents

Matériau d'emballage et son procédé de préparation Download PDF

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Publication number
WO2018106191A1
WO2018106191A1 PCT/SG2017/050605 SG2017050605W WO2018106191A1 WO 2018106191 A1 WO2018106191 A1 WO 2018106191A1 SG 2017050605 W SG2017050605 W SG 2017050605W WO 2018106191 A1 WO2018106191 A1 WO 2018106191A1
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WO
WIPO (PCT)
Prior art keywords
antimicrobial agent
packaging material
natural
natural antimicrobial
degradable polymer
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PCT/SG2017/050605
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English (en)
Inventor
Eng San THIAN
Zuyong WANG
Yi Min TAN
Bow Ho
Original Assignee
National University Of Singapore
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Application filed by National University Of Singapore filed Critical National University Of Singapore
Priority to JP2019530688A priority Critical patent/JP2020500792A/ja
Publication of WO2018106191A1 publication Critical patent/WO2018106191A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D65/00—Wrappers or flexible covers; Packaging materials of special type or form
    • B65D65/38—Packaging materials of special type or form
    • B65D65/46—Applications of disintegrable, dissolvable or edible materials
    • B65D65/466—Bio- or photodegradable packaging materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D65/00—Wrappers or flexible covers; Packaging materials of special type or form
    • B65D65/38—Packaging materials of special type or form
    • B65D65/46—Applications of disintegrable, dissolvable or edible materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/28—Applications of food preservatives, fungicides, pesticides or animal repellants
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00—Compositions of unspecified macromolecular compounds
    • C08L101/16—Compositions of unspecified macromolecular compounds the macromolecular compounds being biodegradable
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L97/00—Compositions of lignin-containing materials
    • C08L97/005—Lignin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L99/00—Compositions of natural macromolecular compounds or of derivatives thereof not provided for in groups C08L89/00 - C08L97/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/90—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in food processing or handling, e.g. food conservation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
    • Y02W90/00—Enabling technologies or technologies with a potential or indirect contribution to greenhouse gas [GHG] emissions mitigation
    • Y02W90/10—Bio-packaging, e.g. packing containers made from renewable resources or bio-plastics

Definitions

  • Various embodiments relate to materials and methods in general, and more particularly, to materials and methods for packaging applications, such as packaging materials used in food technology.
  • Landfill and incineration are the primary methods used in the disposal of these plastic wastes.
  • land filling is not sustainable in the long run as non-degradable polymers remain in the environment even after a very long time.
  • urban planners are always faced with the pressure of having to source for more land space for land filling.
  • burning plastics in incinerators produces toxic by-products that pollute the environment.
  • Physical recycling of the plastic packaging is often impractical and economically inconvenient due to contamination by foodstuff and biological substances.
  • a packaging material comprises a degradable polymer and a natural antimicrobial agent, wherein the degradable polymer forms a polymeric matrix within which the natural antimicrobial agent is dispersed.
  • a method of preparing a packaging material according to the first aspect comprises providing a natural antimicrobial agent, and dispersing the natural antimicrobial agent in a degradable polymer to obtain the packaging material.
  • a packaging material according to the first aspect or a packaging material prepared by a method according to the second aspect in food packaging is provided.
  • FIG. 1A is a schematic diagram showing two-roll milling as a first step in fabricating green packaging films according to an embodiment.
  • PCL denotes poly(8-caprolactone) .
  • FIG. IB is a schematic diagram showing combined sieving and two-roll milling as a second step in fabricating green packaging films according to an embodiment.
  • PCL denotes poly(8-caprolactone)
  • CS denotes chitosan
  • GFSE denotes grapefruit seed extract.
  • FIG. 1C is a schematic diagram showing heat pressing as a third step in fabricating green packaging films according to an embodiment.
  • PCL denotes poly(s- caprolactone)
  • CS denotes chitosan
  • GFSE denotes grapefruit seed extract.
  • FIG. 2A is a schematic diagram showing dissolving step in fabrication of CS/GFSE particulates.
  • FIG. 2B is a schematic diagram showing freeze drying step in fabrication of CS/GFSE particulates.
  • FIG. 2C is a schematic diagram showing collection of powder step in fabrication of CS/GFSE particulates.
  • FIG. 3A is an optical image depicting gross appearance and flexibility of the as- fabricated PCL film.
  • FIG. 3B is an optical image depicting gross appearance and flexibility of the as- fabricated PCL/CS composite film (PCL/CS film: 15 wt.% of CS).
  • FIG. 3C is an optical image depicting gross appearance and flexibility of the as- fabricated PCL/CS/GFSE composite film (PCL/CS/GFSE film: 15 wt.% of CS/GFSE (CS:GFSE ratio, 1: 1 g/ml)).
  • FIG. 3D is an optical image depicting gross appearance and flexibility of the as- fabricated CS/GFSE composite film (CS/GFSE film: 1: 1 g/ml).
  • FIG. 3E is an optical image depicting gross appearance and flexibility of the as- fabricated PE film (PE denotes polyethylene).
  • FIG. 3F is an optical image depicting transparency of the as-fabricated PCL film.
  • FIG. 3G is an optical image depicting transparency of the as-fabricated PCL/CS composite film (PCL/CS film: 15 wt.% of CS).
  • FIG. 3H is an optical image depicting transparency of the as-fabricated PCL/CS/GFSE composite film (PCL/CS/GFSE film: 15 wt.% of CS/GFSE (CS:GFSE ratio, 1: 1 g/ml)).
  • FIG. 31 is an optical image depicting transparency of the as-fabricated CS/GFSE composite film (CS/GFSE film: 1: 1 g/ml).
  • FIG. 3 J is an optical image depicting transparency of the as-fabricated PE film.
  • FIG. 4A is an optical image depicting droplet of water before (top) and after (bottom) sliding on PCL film. Contact angle is 74.4 + 1.4 °.
  • FIG. 4B is an optical image depicting droplet of water before (top) and after (bottom) sliding on PCL/CS composite film. Contact angle is 75.0 + 2.7 °.
  • FIG. 4C is an optical image depicting droplet of water before (top) and after (bottom) sliding on PCL/CS/GFSE composite film. Contact angle is 50.0 ⁇ 7.8 °.
  • FIG. 4D is an optical image depicting droplet of water before (top) and after (bottom) sliding on PE film. Contact angle is 95.3 + 4.6 °.
  • FIG. 5A is a scanning electron microscopy (SEM) image depicting surface morphology of PCL/CS composite film (PCL/CS film: 15 wt.% of CS). Scale bar denotes 50 ⁇ .
  • FIG. 5B is a scanning electron microscopy (SEM) image depicting surface morphology of PCL/CS composite film (PCL/CS film: 15 wt.% of CS). Scale bar denotes 10 ⁇ .
  • FIG. 5C is a scanning electron microscopy (SEM) image depicting cross-sectional view of PCL/CS composite film (PCL/CS film: 15 wt.% of CS). Scale bar denotes 100 ⁇ .
  • FIG. 5D is a scanning electron microscopy (SEM) image depicting cross-sectional view of PCL/CS composite film (PCL/CS film: 15 wt.% of CS). Scale bar denotes 20 ⁇ .
  • FIG. 6 is a graph showing Fourier Transform Infrared spectroscopy (FTIR) spectra of PCL/CS composite film (PCL/CS film: 15 wt.% of CS) showing typical functional groups of PCL and CS.
  • FTIR Fourier Transform Infrared spectroscopy
  • FIG. 7 A is a graph showing UV-vis spectra of PCL/CS composite film as compared to pure PCL film.
  • FIG. 7B is a graph showing antioxidant property of PCL/CS composite film (DPPH: l,l-diphenyl-2-picrylhydrazyl; PCL/CS film: 15 wt.% of CS).
  • FIG. 8 is a graph showing degradation profile of PCL/CS composite film in seawater as compared to pure PCL film (PCL/CS film: 15 wt.% of CS).
  • FIG. 9 are optical images depicting preliminary study on fungal growth in bread samples packed in PE, PCL, PCL/CS and PCL/CS/GFSE films and stored at 24 °C for up to 13 days (Control groups: commercialised food packaging polyethylene (PE) film, and pure PCL film; PCL/CS film: 15 wt.% of CS; PCL/CS/GFSE film: 15 wt.% of CS/GFSE (CS:GFSE ratio: 1: 1 g/ml); dark arrows: initial fungal growth).
  • PE commercialised food packaging polyethylene
  • the packaging material according to various embodiments disclosed herein has antimicrobial/antifungal properties due to presence of a natural antimicrobial agent as an additive in the packaging material.
  • a natural antimicrobial agent as an additive in the packaging material.
  • the packaging material according to embodiments disclosed herein is an environmentally- friendly, green packaging material, and its preparation involves a green fabrication step free from chemical additives and toxic residues.
  • the packaging material according to embodiments disclosed herein may be particularly suitable as a food packaging material on various food products such as confectionaries, seafood, red meat, and dairy products, to name only a few.
  • various embodiments refer in a first aspect to a packaging material comprising a degradable polymer and a natural antimicrobial agent.
  • the term "packaging material” refers to a material for at least partially or completely encompassing or enclosing an object.
  • the packaging material may function as a barrier layer or act an interface between the object and the environment to seal and/or protect the object from degradation and/or contamination by pollutants or contaminants that may be present in the environment.
  • the packaging material may be in direct contact with the object, which may translate into a decrease in the rate at which the object degrades due to action of the natural antimicrobial agent.
  • the packaging material may be used to form containers that may be used to hold or to accommodate perishable items, such as food items.
  • the packaging material is a packaging film.
  • the packaging film may be in the form of a flat sheet or a continuous layer.
  • the packaging material may, for example, be a food packaging film.
  • the packaging film is in direct contact with food, and may be used as a cling wrap, a cling film, or a food wrap for packaging food, or to seal food items in containers.
  • the packaging film may be of a sufficient thickness to provide barrier and mechanical properties as well as ease of handling, and may have a suitable thickness depending on intended application. For example, while thick films, such as films having a thickness of 50 ⁇ or more, have better barrier properties in general, film flexibility and transparency may be compromised for such films. On the other hand, thin films, such as films having a thickness of 10 ⁇ or in the range of about 10 ⁇ to about 20 ⁇ , may result in less material usage, while still providing sufficient barrier and mechanical properties.
  • the packaging material comprises a degradable polymer and a natural antimicrobial agent. As used herein, the term "polymer" refers to a large molecule that is built up by repetition of smaller chemical units.
  • the repeat unit of the polymer is usually equivalent or nearly equivalent to the monomer, i.e. starting material from which the polymer is formed.
  • the repeat units of the polymer may be connected to one another via covalent bonds.
  • the repetition is linear, such as in the case of a polymer chain having a single backbone with no branches.
  • the chains are branched or interconnected to form three-dimensional networks.
  • the polymer is a degradable polymer, meaning that the polymer has a molecular structure which may be broken down or decompose into smaller molecules over a period of time (e.g., within days, or months, or years).
  • the time required for degradation may depend on factors such as type of degradable polymer and environmental conditions.
  • the degradable polymer may degrade over a period of more than 20 years.
  • the degradable polymer may degrade over a period of up to 20 years, such as up to 15 years, 10 years, 8 years, 5 years, or 2 years.
  • Degradation period of polycaprolactone film in a dry environment at room temperature for example, may be up to 8 years.
  • the degradation or decomposition of the degradable polymer may take place by various mechanisms due to action of, for example, naturally occurring microorganisms such as bacterial, fungi and algae; light; oxidation; and/or chemicals (such as water).
  • the degradable polymer may accordingly be a biodegradable polymer, a photodegradable polymer, an oxidatively degradable polymer, and/or a hydrolytically degradable polymer.
  • degradable polymers include, but are not limited to, polymers and oligomers of glycolide, lactide, polylactic acid, polyesters of a -hydroxy acids, including lactic acid and glycolic acid, such as the poly(a-hydroxy) acids including polyglycolic acid, poly(DL-lactic-co-glycolic acid) (PLGA), poly-L-lactic acid (PLLA), and terpolymers of DL- lactide and glycolide; ⁇ -caprolactone and ⁇ -caprolactone copolymerized with polyesters; polylactones and polycaprolactones including poly(caprolactone) (PCL), poly(s- caprolactone), poly(5-valerolactone) and poly (gamma-butyrolactone); polyanhydrides; polyorthoesters; other hydroxy acids; polydioxanone; and other biologically degradable polymers that are non-toxic or are present as metabolites in the body.
  • poly(a-hydroxy) acids
  • polyaminoacids include, but are not limited to, polylysine (PLL), poly L-aspartic acid, poly L-glutamic acid, and styrene-maleic acid anhydride copolymer.
  • polyethylene glycol includes, but are not limited to, poly(ethylene glycol)-di- (ethylphosphatidyl(ethylene glycol)) (PEDGA), poly(ethylene glycol)-co-anhydride, poly(ethylene glycol)co-lactide, poly(ethylene glycol)-co-glycolide and poly (ethylene glycol)-co-orthoester.
  • acrylamide polymers include, but are not limited to, polyisopropylacrylamide, and poly acrylamide.
  • acrylate polymers include, but are not limited to, diacrylates such as polyethylene glycol diacrylate (PEGDA), oligoacrylates, methacrylates, dimethacrylates, oligomethoacrylates and PEG- oligoglycolylacrylates.
  • PEGDA polyethylene glycol diacrylate
  • carboxy alkyl cellulose include, but are not limited to, carboxymethyl cellulose and partially oxidized cellulose.
  • the degradable polymer is selected from the group consisting of poly(8-caprolactone), aliphatic polyester, polylactide, poly(glycolide), poly(hydroxy ester ether), poly(hydroxybutyrate), poly(anhydride), polycarbonate, poly(amino acid), poly(ethylene oxide), poly(phosphazene), polyether ester, polyester amide, polyamide, combinations thereof, and copolymers thereof.
  • the degradable polymer comprises poly(8-caprolactone).
  • the degradable polymer may have a weight average molecular weight in the range of about 60000 to about 100000, such as about 70000 to about 90000, or about 75000 to about 85000.
  • the packaging material also contains a natural antimicrobial agent.
  • a natural antimicrobial agent As used herein, the term “natural” means that the substance may be found in nature.
  • antimicrobial refers to the ability to inhibit, or control the spread or growth of microbes, which are organisms that are unicellular or live in a colony of cellular organisms. Examples of microbes include bacteria, mycobacteria, fungi, yeasts, archea, viruses, protest, or parasites.
  • antibacterial and antifungal refer respectively to the ability to inhibit, or control the spread or growth of bacterial and fungi.
  • the antimicrobial agent is an antibacterial and/or an antifungal agent.
  • the antimicrobial agent is one that is able to inhibit, or control the spread or growth of microbes selected from the group consisting of Gram-positive bacteria, Gram-negative bacteria, fungus, and combinations thereof.
  • Gram-positive bacteria refers to bacterial cells which stain violet (positive) in the Gram stain assay.
  • the Gram stain binds peptidoglycan which is abundant in the cell wall of Gram-positive bacteria.
  • the cell wall of "Gram-negative bacteria” is low in peptidoglycan, thus Gram-negative bacteria adopt the counterstain in the Gram stain assay.
  • the bacteria may, for example, be of the genus Acinetobacter, Actinomyces, Aeromonas, Bordetella, Borrelia, Brucella, Burkholderia, Campylobacter, Chlamydia, Clostridium, Corynebacterium, Enterococcus, Erwinia, Escherichia, Francisella, Haemophilus, Helicobacter, Klebsiella, Legionella, Leptospira, Listeria, Mycobacterium, Mycoplasma, Neisseria, Pseudomonas, Rickettsia, Salmonella, Shigella, Staphylococcus, Streptococccus, Treponema, Veillonella, Vibrio or Yersinia.
  • the bacteria is selected from the group consisting of Staphylococcus aureus, Mycobacterium smegmatis, Pseudomonas aeruginosa, Burkholderia cepacia, Klebsiella pneumonia, Aeromonas hydrophila, Erwinia carotovora, Erwinia chrysanthemi, and Escherichia coli.
  • the fungus may, for example, be of the species Candida albicans, Candida tropicalis, Candida (Clasvispora) lusitaniae, Candida (Pichia) guillermondii, Lodderomyces elongisporus, Debaryomyces hansenii, Pichia stipitis, Asperigillus fumigatus, Blastomyces dermatitidis, Cladophialophora bantiana, Coccidioides immitis, Cryptococcus neoformans, Fusarium spp., Microsporum spp., Penicillium marneffei or Trichophyton spp.
  • the antimicrobial agent is one that is able to inhibit, or control the spread or growth of microbes selected from the group consisting of Escherichia coli, Staphylococcus aureus, Candida albicans, and combinations thereof.
  • the natural antimicrobial agents may, for example, be obtained from natural compounds such as weak organic acids, organic compounds, antimicrobial enzymes, bacteriocins, triclosan, fungicides, nisin, fruit and plant extracts, essential oils, and/or natural polysaccharide.
  • the natural antimicrobial agent is selected from the group consisting of chitosan, chitin, lignin, derivatives thereof, combinations thereof, and copolymers thereof.
  • lignin may include, for example, lignin esters, lignin ethers, hydroxyalkylated lignin, acylated lignin, carboxy lignins, or hydroxyalkoxy lignins.
  • the natural antimicrobial agent comprises chitosan.
  • Chitosan has good biodegradability, biocompatibility, and antimicrobial activity, which render its usefulness for biomedical applications.
  • chitosan also includes quaternized chitosan, also referred to herein as quaternary ammonium chitosan, which is a derivative of chitosan that is prepared by introducing a quaternary ammonium group on a dissociative hydroxyl group or amino group of the chitosan.
  • quaternized chitosan possess a permanent positive charge on the polysaccharide backbone. Due to this permanent positive charge, quaternized chitosan may also be termed as cationic quaternized chitosan.
  • chitosan is represented by formula (I)
  • each X is independently selected from -NH-C(0)-CH 3 , -NCR ⁇ R 2 ) and -N + (R 3 )(R 4 )(R 5 ), provided that at least one X is -N + (R 3 )(R 4 )(R 5 ), R 1 , R 2 , R 3 , R 4 , and R 5 are independently selected from H and Ci-is alkyl, and k is an integer from 3 to 3000.
  • Ci-Cis alkyl refers to a fully saturated aliphatic hydrocarbon having 1 to 18 carbon atoms, e.g. it means that the alkyl group comprises 1 carbon atom, 2 carbon atoms, 3 carbon atoms etc. up to and including 18 carbon atoms.
  • the Ci-Cis alkyl group may be straight chain or branched chain, and may be substituted or unsubstituted. Exemplary substituents include, but are not limited to, Ci-6 aliphatic group, hydroxy, alkoxy, cyano, halogen group, nitro, silyl, and amino, including mono- and di-substituted amino groups.
  • substituents include Ci-Cio alkoxy, C5-C10 aryl, C5-C10 aryloxy, sulfhydryl, C5-C10 aryl, thio, halogen such as F, CI, Br, I, hydroxyl, amino, sulfonyl, nitro, cyano, and carboxyl.
  • alkyl groups may be, but are not limited to, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, s-butyl, t-butyl, n-hexyl, n-heptyl, n-octyl, n-nonyl or n-decyl and the like.
  • k is an integer from 3 to 3000.
  • k may be an integer from 3 to 2800, 3 to 2400, 3 to 1800, 3 to 1600, 3 to 600, 120 to 3000, 600 to 3000, 700 to 2500, 1500 to 2500, 1200 to 2400, 1600 to 2800, or 1800 to 2800.
  • R 1 and R 2 are selected from H and CMS alkyl, and R 3 , R 4 , and R 5 are each independently Ci-io alkyl.
  • R 1 and R 2 are H, and R 3 , R 4 , and R 5 are each independently Ci-io alkyl.
  • R 3 and R 4 are methyl and R 5 is Ci-io alkyl, preferably methyl, ethyl, n-propyl, n-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, n-nonyl or n-decyl.
  • R 3 and R 4 are methyl and R 5 is selected from the group consisting of methyl, ethyl, n-propyl, n-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, n-nonyl, and n-decyl.
  • the natural antimicrobial agent is able to inhibit, or control the spread or growth of microbes
  • the natural antimicrobial agent may further comprise a natural bioactive agent to enhance antimicrobial and/or antifungal properties of the natural antimicrobial agent.
  • bioactive agent refers to a substance that has an effect such as a biological effect on a living organism.
  • the natural bioactive agent is a substance which may be found in nature.
  • the natural bioactive agent is selected from the group consisting of grapefruit seed extract, olive leaf extract, natamycin, chinokitiol, lysozyme, bacteriocins, essential oils, tea tree oil, lemon peel, pomelo, cinnamon, and combinations thereof.
  • the natural bioactive agent comprises or consists of grapefruit seed extract, which refers to one or more antimicrobial components derived from grapefruit seeds, obtainable by extraction using an organic solvent.
  • the organic solvent may, for example, be an organic solvent containing one or more hydroxyl groups such as glycols.
  • Ratio of the natural bioactive agent to the natural antimicrobial agent may be in the range of about 1: 1 to about 3: 1 ml/g to allow ease of fabrication, such as about 1: 1 to about 3:2 ml/g, about 1: 1 to about 2: 1 ml/g, about 1: 1 to about 5:2 ml/g, about 3:2 to about 3: 1 ml/g, about 2: 1 to about 3: 1 ml/g, or about 3:2 to about 2: 1 ml/g.
  • the degradable polymer forms a polymeric matrix within which the natural antimicrobial agent is dispersed.
  • the natural antimicrobial agent may be in the form of particles.
  • the natural microbial agent may be at least substantially uniformly dispersed in the polymeric matrix.
  • substantially uniformly dispersed it is meant that distribution of the natural microbial agent within the degradable polymer is substantially even or similar in all regions therein, with no particular region in the degradable polymer in which concentration or proportion of the natural microbial agent is substantially greater or lesser as compared to any other region therein.
  • the natural antimicrobial agent comprises particles having a size of 75 ⁇ or less, such as a size in the range of about 5 ⁇ to about 75 ⁇ , about 10 ⁇ to about 75 ⁇ , about 20 ⁇ to about 75 ⁇ , about 30 ⁇ to about 75 ⁇ , about 50 ⁇ to about 75 ⁇ , about 5 ⁇ to about 60 ⁇ , about 5 ⁇ to about 50 ⁇ , or about 30 ⁇ to about 50 ⁇ .
  • Amount of the natural antimicrobial agent in the polymeric matrix may be in the range of about 0.01 wt% to about 40 wt%, such as about 0.01 wt% to about 35 wt%, about 0.01 wt% to about 20 wt%, about 0.01 wt% to about 15 wt%, about 1 wt% to about 25 wt%, about 15 wt% to about 40 wt%, or about 25 wt% to about 40 wt%.
  • amount of the natural antimicrobial agent in the polymeric matrix is in the range of about 0.01 wt% to about 15 wt %, which may be an optimal range to achieve mechanical properties, such as tensile strength and break strain, comparable to those exhibited by commercial polyethylene (PE) packaging films.
  • PE polyethylene
  • Various embodiments refer in a second aspect to a method of preparing a packaging material according to the first aspect.
  • the method comprises providing a natural antimicrobial agent. Examples of suitable natural antimicrobial agent have already been discussed above.
  • the natural antimicrobial agent may further comprise a natural bioactive agent.
  • Suitable natural bioactive agents have already been mentioned above.
  • the natural bioactive agent comprises or consists of grapefruit seed extract.
  • the method of preparing the packaging material is not limited to grapefruit seed extract, and may be adopted for other types of natural bioactive agent such as those mentioned above since the method is not dependent on the chemical properties of the natural bioactive agent.
  • the natural antimicrobial agent further comprises a natural bioactive agent
  • providing the natural antimicrobial agent may comprise dissolving the natural antimicrobial agent and the natural bioactive agent in an aqueous solution, such as water or a buffer solution, to form an aqueous mixture, and drying the aqueous mixture to obtain the natural antimicrobial agent.
  • Dissolving the natural antimicrobial agent and the natural bioactive agent in an aqueous solution may, for example, be carried out with ratio of the natural bioactive agent to the natural antimicrobial agent in the range of about 1: 1 to about 3: 1 ml/g, or any suitable sub-ranges within the specified range.
  • dissolving the natural antimicrobial agent and the natural bioactive agent in an aqueous solution may be carried out at ambient conditions. A substantial portion of or all of the natural bioactive agent and the natural antimicrobial agent may be dissolved in the aqueous solution to form the aqueous mixture.
  • the aqueous mixture may be dried using any suitable drying method to obtain the natural antimicrobial agent comprising the natural bioactive agent.
  • drying the aqueous mixture is carried by a two-step procedure of freeze drying and vacuum drying.
  • Various embodiments of the freeze drying technique disclosed herein are based upon principle of sublimation of water.
  • simultaneous action of vacuum and temperature may facilitate a tight packing order of the natural antimicrobial agent and the natural bioactive agent.
  • water present in the aqueous mixture may sublime.
  • water may be removed from the aqueous mixture to leave only the natural antimicrobial agent and the natural bioactive agent to allow physical binding of the natural bioactive agent to the natural antimicrobial agent.
  • water may be evaporated or sublimed from the aqueous mixture to form the natural antimicrobial agent comprising the natural bioactive agent. This renders the process green as hazardous and toxic solvents are not used.
  • Freeze drying the aqueous mixture may be carried out at any suitable temperature which is sufficient to sublime water that is present in the mixture.
  • freeze drying the aqueous mixture is carried out at a temperature in the range of about -50 °C to about 0 °C, such as about -30 °C to about 0 °C, about -10 °C to about 0 °C, about -50 °C to about -10 °C, about -50 °C to about -20 °C, about -50 °C to about -30 °C, about -40 °C to about -10 °C, about -30 °C to about -20 °C.
  • freeze drying the aqueous mixture is carried out at a temperature of about -40 °C.
  • the freeze drying may be carried out for a time period in the range of about 1 hour to about 3 hours, such as about 1.5 hours to about 2.5 hours, or about 2 hours. Subsequently, the aqueous mixture which has been subjected to freeze drying may be vacuum dried for a time period in the range of about 1 day to about 3 days, such as about 1.5 days to about 2.5 days, or about 2 days.
  • the natural antimicrobial agent is in the form of particles, which may have a size of 75 ⁇ or less.
  • the method disclosed herein comprises dispersing the natural antimicrobial agent in a degradable polymer. This may comprise melting the degradable polymer; mixing the natural antimicrobial agent with the molten degradable polymer to form a polymeric mixture; and heat pressing the polymeric mixture.
  • Melting the degradable polymer may, for example, be carried out at a temperature above melting point of the degradable polymer using a two-roll milling process, such as that shown in FIG. 1A.
  • the rollers may move in opposing directions, and shear force that is created by the rollers may be used to mix or disperse materials that is fed onto the rollers.
  • Speed at which the rollers rotate may be any suitable speed, such as a speed in the range of about 2 rpm to about 10 rpm.
  • melting the degradable polymer may be carried out at about 65 °C.
  • Mixing the natural antimicrobial agent with the molten degradable polymer may comprise sieving the natural antimicrobial agent onto the molten degradable polymer while the two-roll milling process is carried out, such as that depicted in FIG. IB.
  • the polymeric mixture may be removed from the rollers and be subjected to a heat-pressing process, such as that shown in FIG. 1C.
  • heat pressing the polymeric mixture is carried out at a pressure in the range of about 20 MPa to about 40 MPa, such as about 25 MPa to about 35 MPa, or about 30 MPa.
  • the packaging material may be obtained in the form of a packaging film.
  • Various embodiments refer in a further aspect to use of a packaging material according to the first aspect or a packaging material prepared by a method according to the second aspect in food packaging.
  • the packaging material according to embodiments disclosed herein have demonstrated suitable optical and mechanical properties as food packaging films, and with sufficient UV-absorption, antioxidant and antimicrobial/antifungal functions, but yet able to degrade naturally.
  • the packaging material disclosed herein have the capability to degrade in natural environment (for example: in seawater), yielding non-toxic products, and with a slow degradation rate for ensuring long- term usage period for prolonged food safety against bacterial/fungal growth, thereby minimizing food wastage.
  • Various embodiments presents a method on the design and fabrication of green packaging films for food technology.
  • the films according to embodiments disclosed herein are designed with adequate optical and mechanical properties as food packaging films, and with sufficient UV-absorption, antioxidant and antimicrobial/antifungal functions, but yet able to degrade naturally.
  • the films disclosed herein have the capability to degrade in natural environment (for example: in seawater), yielding non-toxic products, and with a slow degradation rate for ensuring long-term usage period for prolonged food safety against bacterial/fungal growth, thereby minimizing food wastage.
  • the green packaging films disclosed herein may comprise two components of:
  • a degradable polymeric matrix as a barrier between food product and outside environment, having adequate optical and mechanical properties and at the same time, having adequate UV-absorption and antioxidant functions.
  • the polymeric matrix may also serve as a support for the natural additive portion;
  • the green packaging films may be fabricated using a three-step physical method without using any solvents/chemicals.
  • a degradable polymer for example: poly(s- caprolactone) (PCL) depicted in FIG. 1A
  • PCL poly(s- caprolactone)
  • FIG. 1A A degradable polymer depicted in FIG. 1A
  • the matrix may be blended with small particulates (for example: chitosan (CS) powder with a particle size less than 75 ⁇ ) as an additive via a combination of sieving and two-roll milling techniques (FIG. IB).
  • small particulates for example: chitosan (CS) powder with a particle size less than 75 ⁇
  • the small particulates additive portion may be altered by inclusion of natural component (for example: grapefruit seed extract (GFSE)) via a combination of dissolving and freeze drying techniques (FIG. 2A to FIG. 2C) to enhance antimicrobial/antifungal properties.
  • natural component for example: grapefruit seed extract (GFSE)
  • FIG. 2A to FIG. 2C a combination of dissolving and freeze drying techniques
  • the composite pellets may then be heat-pressed into films (for example: at 65 °C and 30 MPa for PCL/CS and PCL/CS/GFSE films in FIG. 1C).
  • PE film 199.0 + 24.1 7.8 + 1.0 4.2 + 0.1 30.5 + 1.9 191.5 + 67.2
  • the green packaging film exhibits a crack-free topography on its surface (FIG. 5A and FIG. 5B), and shows additive particulates dispersing uniformly within the polymeric matrix (FIG. 5C and FIG. 5D).
  • Such film shows a combination of chemical properties from both the matrix and additive particulates, without inducing any changes to the typical chemical bonds of each component during the fabrication process (FIG. 6).
  • the green packaging film (for example: 15 wt.% of CS powder) obtains improved UV-absorption as compared to that of the pure PCL film (FIG. 7A), and exhibits a robust antioxidant capability with nearly 90 % of DPPH (DPPH: l,l-diphenyl-2-picrylhydrazyl; a standard oxidation agent) being scavenged within 72 hr (FIG. 7B).
  • the film also exhibits a degradation ability in natural environment (for example: in seawater), and possesses a slow degradation rate, that can be altered via the incorporation of additive particulates (for example: 15 wt.% of CS powders in FIG. 8).
  • additive particulates for example: 15 wt.% of CS powders in FIG. 8.
  • Such film (for example: containing 15 wt.% of CS powder and 15 wt.% of CS/GFSE powder) exhibits a potential to retard the incidence of fungal growth so as to increase the shelf-life of food products (for example: increasing the shelf-life of bread by approximate 2-3 times for the green packaging films as compared to the PE and PCL films in FIG. 9), being attributed to the incorporation of the additive particulates.

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  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biodiversity & Conservation Biology (AREA)
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Abstract

L'invention concerne un matériau d'emballage. Le matériau d'emballage comprend un polymère dégradable (par exemple, du poly (ε-caprolactone)) et un agent antimicrobien naturel (par exemple, du chitosane), le polymère dégradable formant une matrice polymère dans laquelle l'agent antimicrobien naturel est dispersé. L'invention concerne également un procédé de préparation d'un matériau d'emballage, et l'utilisation du matériau d'emballage dans un emballage alimentaire.
PCT/SG2017/050605 2016-12-09 2017-12-07 Matériau d'emballage et son procédé de préparation WO2018106191A1 (fr)

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CN114149581A (zh) * 2021-10-08 2022-03-08 南开大学 一种木质素基氢键有机骨架纳米材料及其制备方法、应用
CN114149581B (zh) * 2021-10-08 2022-09-09 南开大学 一种木质素基氢键有机骨架纳米材料及其制备方法、应用
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