WO2018101684A3 - 글리세롤로부터 1,3-프로판디올을 고생산하는 락토바실러스 루테리 ch53 균주 및 이의 용도 - Google Patents

글리세롤로부터 1,3-프로판디올을 고생산하는 락토바실러스 루테리 ch53 균주 및 이의 용도 Download PDF

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WO2018101684A3
WO2018101684A3 PCT/KR2017/013587 KR2017013587W WO2018101684A3 WO 2018101684 A3 WO2018101684 A3 WO 2018101684A3 KR 2017013587 W KR2017013587 W KR 2017013587W WO 2018101684 A3 WO2018101684 A3 WO 2018101684A3
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propandiol
strain
glycerol
lactobacillus reuteri
high production
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PCT/KR2017/013587
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French (fr)
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WO2018101684A2 (ko
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김철호
오백록
서정우
허선연
주정현
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한국생명공학연구원
주식회사 엑티브온
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Priority to US16/461,596 priority Critical patent/US11446234B2/en
Publication of WO2018101684A2 publication Critical patent/WO2018101684A2/ko
Publication of WO2018101684A3 publication Critical patent/WO2018101684A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225—Lactobacillus

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
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  • Cosmetics (AREA)

Abstract

본 발명은 글리세롤로부터 1,3-프로판디올을 고생산하는 락토바실러스 루테리 CH53 균주 및 이의 용도에 관한 것으로, 본 발명의 락토바실러스 루테리 CH53 균주는 글리세롤 또는 폐글리세롤을 고농도의 1,3-프로판디올로 매우 높은 수율로 전환할 수 있는 점을 확인하였다. 따라서, 본 발명에 따른 1,3-프로판디올 고생산 유산균 락토바실러스 루테리 CH53 균주는 인체에 안전한 균주(GRAS, Generally Recognized As Safe)인 유산균의 일종으로, 이를 이용하여 폐글리세롤을 1,3-프로판디올 생산에 활용한다면 기존의 GMO 균주와 달리 안전하면서 환경적인 측면이나, 자원의 재순환 활용이라는 이점을 제공할 수 있어 관련 산업에 매우 유용하다.
PCT/KR2017/013587 2016-11-29 2017-11-27 글리세롤로부터 1,3-프로판디올을 고생산하는 락토바실러스 루테리 ch53 균주 및 이의 용도 WO2018101684A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US16/461,596 US11446234B2 (en) 2016-11-29 2017-11-27 Lactobacillus reuteri CH53 strain having high productivity of 1,3-propanediol from glycerol and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020160160302A KR101876980B1 (ko) 2016-11-29 2016-11-29 글리세롤로부터 1,3-프로판디올을 고생산하는 락토바실러스 루테리 ch53 균주 및 이의 용도
KR10-2016-0160302 2016-11-29

Publications (2)

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WO2018101684A2 WO2018101684A2 (ko) 2018-06-07
WO2018101684A3 true WO2018101684A3 (ko) 2018-09-20

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PCT/KR2017/013587 WO2018101684A2 (ko) 2016-11-29 2017-11-27 글리세롤로부터 1,3-프로판디올을 고생산하는 락토바실러스 루테리 ch53 균주 및 이의 용도

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US (1) US11446234B2 (ko)
KR (1) KR101876980B1 (ko)
WO (1) WO2018101684A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102122652B1 (ko) * 2018-09-07 2020-06-12 건국대학교 산학협력단 락토바실러스 루테리 제제를 이용한 피부개선용 조성물
KR102651370B1 (ko) * 2021-04-20 2024-03-26 주식회사 엑티브온 유기산 내성 및 글리세롤로부터 1,3-프로판디올로의 전환율이 우수한 락토바실러스 루테리 jh53 균주 및 이의 용도

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040048620A (ko) * 2002-12-04 2004-06-10 한국생명공학연구원 폐글리세롤을 １,３-프로판디올로 전환하는 신균주 및이를 이용한 １,３-프로판디올 생산방법
KR20130011343A (ko) * 2011-07-21 2013-01-30 한국생명공학연구원 글리세롤 발효 미생물 변이체를 이용하여 디올화합물을 고수율로 생산하는 방법

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* Cited by examiner, † Cited by third party
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KR101145405B1 (ko) 2008-12-03 2012-05-16 한국생명공학연구원 글리세롤 산화경로가 차단된 １、３―프로판디올 생산 변이체
KR101220499B1 (ko) 2010-05-25 2013-01-10 한국생명공학연구원 글리세롤로부터 3-하이드록시프로피온산을 고수율로 제조하는 방법

Patent Citations (2)

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KR20040048620A (ko) * 2002-12-04 2004-06-10 한국생명공학연구원 폐글리세롤을 １,３-프로판디올로 전환하는 신균주 및이를 이용한 １,３-프로판디올 생산방법
KR20130011343A (ko) * 2011-07-21 2013-01-30 한국생명공학연구원 글리세롤 발효 미생물 변이체를 이용하여 디올화합물을 고수율로 생산하는 방법

Non-Patent Citations (3)

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Title
JOLLY, JYOTSNA: "Biosynthesis of 1, 3-propanediol from glycerol with Lactobacillus reuteri: effect of operating variables", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, vol. 118, no. 2, 2014, pages 188 - 194, XP055602854, DOI: doi:10.1016/j.jbiosc.2014.01.003 *
RICCI, MARIA ANTONIETTA: "Improved 1, 3-propanediol synthesis from glycerol by the robust Lactobacillus reuteri strain DSM 20016", JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, vol. 25, no. 6, 2015, pages 893 - 902, XP055606921 *
VAIDYANATHAN, HEMA: "Glycerol conversion to 1, 3-propanediol is enhanced by the expression of a heterologous alcohol dehydrogenase gene in Lactobacillus reuteri", AMB EXPRESS, vol. 1, 8 January 2011 (2011-01-08), pages 1 - 37, XP055143214 *

Also Published As

Publication number Publication date
US11446234B2 (en) 2022-09-20
KR101876980B1 (ko) 2018-07-11
KR20180060605A (ko) 2018-06-07
US20190365640A1 (en) 2019-12-05
WO2018101684A2 (ko) 2018-06-07

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