WO2018101673A2 - Composition de blanchiment de la peau contenant des fèves de café fermentées utilisées comme principe actif - Google Patents

Composition de blanchiment de la peau contenant des fèves de café fermentées utilisées comme principe actif Download PDF

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Publication number
WO2018101673A2
WO2018101673A2 PCT/KR2017/013389 KR2017013389W WO2018101673A2 WO 2018101673 A2 WO2018101673 A2 WO 2018101673A2 KR 2017013389 W KR2017013389 W KR 2017013389W WO 2018101673 A2 WO2018101673 A2 WO 2018101673A2
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WO
WIPO (PCT)
Prior art keywords
coffee beans
fermented
fermented coffee
skin whitening
cosmetic composition
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PCT/KR2017/013389
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English (en)
Korean (ko)
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WO2018101673A3 (fr
Inventor
안정엽
Original Assignee
바이오앤슈티 주식회사
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Publication of WO2018101673A2 publication Critical patent/WO2018101673A2/fr
Publication of WO2018101673A3 publication Critical patent/WO2018101673A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

Definitions

  • the present invention relates to a cosmetic composition for skin whitening and a health functional food composition for improving skin whitening containing fermented coffee beans fermented with Lactobacillus curvatus strain as an active ingredient.
  • the skin may cause various skin problems by exposure to various harmful substances such as air and ultraviolet rays caused by air pollution and by natural aging and photo aging. Among them, blemishes, freckles and blemishes are one of the biggest skin problems, and many efforts have been made to improve them.
  • melanocytes melanocytes
  • the distribution of blood vessels the thickness of skin and pigment-related factors such as carotenoids and bilirubin are important.
  • melanin produced by the action of various enzymes such as tyrosinase in melanocytes in the human body. Pigmentation of the skin is caused by irritation such as ultraviolet rays or inflammation, and it is also known to be caused by factors such as genetic factors, hormones, foods, and chemicals.
  • tyrosine in melanocytes is converted to dopa by the action of tyrosinase, and then into dopaquinone by the action of dopaoxidase, and then tyrosinase-related protein-1 (tyrosinase-related).
  • Melanin is produced by the action of protein-1 (hereinafter referred to as TRP-1) and tyrosinase-related protein-2 (hereinafter referred to as TRP-2).
  • TRP-1 protein-1
  • TRP-2 tyrosinase-related protein-2
  • TRP-2 also known as DOPA chromium transmutase, activates the reaction of DOPA chromium to 5,6-dihydroxyindole-2-carboxylic acid (DHICA), and TRP-1 converts DHICA to carboxyl indole-quinone. Oxidize.
  • DHICA 5,6-dihydroxyindole-2-carboxylic acid
  • TRP-1 converts DHICA to carboxyl indole-quinone. Oxidize.
  • TRP-1 and TRP-2 are involved in polymerization, which is the final step in the formation of insoluble pigment melanin.
  • TRP-1 tyrosinase-related protein-1
  • TRP-2 tyrosinase-related protein-2
  • whitening agents include kojic acid, arbutin, glutathione and vitamin C, but they do not have a satisfactory whitening effect and are limited in their use due to skin safety.
  • Coffee Rubiaceae belonging to the subgenus kope (Coffee), varieties are grown commercially are largely divided into arabica (Arabica) and Robusta (Robusta-canephora), Riverina and South (Liberica) 3 varieties. Coffee is a representative beverage made with a combination of bitterness, astringent taste, sour taste and sweetness. It is the most widely used beverage all over the world.
  • Coffee is known to have higher free radical scavenging ability, which causes cell damage due to its higher content of antioxidants such as polyphenols.
  • coffee is known to have an excellent protective effect against Alzheimer's, Parkinson's disease, type 2 diabetes, cholesterol, heart disease and cirrhosis, etc., and many studies are being conducted on the pharmacological effects of coffee beyond the preferred foods.
  • Korean Patent No. 1514991 discloses a high functional cosmetic composition comprising a coffee fermentation product and an extract thereof
  • Korean Patent No. 1465506 discloses a cosmetic containing an effective extract of a coffee bean by-product, It is different from the cosmetic composition for skin whitening containing fermented coffee beans fermented with Lactobacillus cobatus strains as an active ingredient.
  • the present invention is derived from the above requirements, the present invention by confirming that the fermented coffee beans fermented with a specific Lactobacillus curvatus strain is excellent in inhibiting tyrosinase activity, Its purpose is to provide a composition for skin whitening containing the fermented coffee beans as an active ingredient.
  • the present invention provides a cosmetic composition for skin whitening containing fermented coffee beans fermented with Lactobacillus curvatus strain as an active ingredient.
  • the present invention also provides a health functional food composition for improving skin whitening containing fermented coffee beans fermented with Lactobacillus curvatus strain as an active ingredient.
  • Fermented coffee beans fermented coffee beans of the present invention with a specific Lactobacillus curvatus strain has excellent tyrosinase inhibitory activity, which can prevent or improve functional cosmetics and skin pigmentation diseases for skin whitening. It can be usefully used as a health functional food.
  • the present invention provides a cosmetic composition for skin whitening containing fermented coffee beans fermented with Lactobacillus curvatus strain as an active ingredient.
  • the Lactobacillus keoba tooth (Lactobacillus curvatus) strain is preferably the Lactobacillus keoba tooth (Lactobacillus curvatus deposited on November 16th 2016 in Korea Culture Center of Microorganisms ) SRCM101123 strain (Accession Number: KCCM11933P), but is not limited thereto.
  • the skin whitening may be shown by inhibiting the activity of tyrosinase, but is not limited thereto.
  • the fermented coffee beans are preferably 12 ⁇ 30 ⁇ 40 °C inoculated with water and Lactobacillus curvatus strain in sterilized coffee beans
  • the liquid cultured fermented coffee beans for 48 hours or the liquid cultured fermented coffee beans may be filtered, more preferably sterilized coffee beans inoculated with water and Lactobacillus curvatus strains After the fermented coffee beans or liquid cultured fermented coffee beans for 24 to 48 hours at 30 ⁇ 37 °C filtered, but is not limited thereto.
  • the whitening effect is to improve or prevent dark skin, blemishes, freckles, dark circles caused by various factors such as exposure to ultraviolet rays, changes in hormonal balance, genetic programs, and make skin beautiful and transparent. Or it intends to maintain the beautiful skin with transparency, reduce the dullness of skin and increase the luster and tension.
  • dark skin, blemishes, freckles, and dark circles are known to be caused by melanocytes (melanocytes) are stimulated by ultraviolet light stimulation or changes in hormonal balance, and thus biosynthetic melanin pigments are deposited on the skin. Therefore, if the production of melanin can be suppressed, it is possible to prevent and improve dark skin, blemishes, freckles and dark circles.
  • the cosmetic composition for skin whitening is a solution, suspension, emulsion, paste, gel, cream, lotion, mask pack, essence, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation And it may have any one formulation selected from the group consisting of a spray, but is not limited thereto.
  • the cosmetic composition consisting of each of these formulations may contain various bases and additives necessary for the formulation of the formulation and are suitable, and the type and amount of these components can be easily selected by those skilled in the art.
  • the cosmetic composition of the present invention may further contain one or more skin whitening active ingredients exhibiting the same or similar functions in addition to the active ingredient.
  • Skin whitening active ingredients include niacinamide, kojic acid and derivatives thereof, arbutin, ascorbic acid and derivatives thereof, hydroquinone and derivatives thereof, resorcinol, cycloalkanone, methylenedioxyphenyl alkanol, 2,7-dinitro Plant extracts such as indazole or vine tangerine extract, rice extract, licorice extract, and the like, but are not limited thereto.
  • the carrier component is animal fiber, vegetable fiber, wax, paraffin, starch, tragacanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide. And the like can be used.
  • the formulation of the cosmetic composition of the present invention is a powder or a spray
  • lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as the carrier component, and in particular, in the case of a spray, additionally chlorofluorohydro Propellants such as carbon, propane-butane or dimethyl ether.
  • a solvent, solvating agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene.
  • a carrier component such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene.
  • the formulation of the cosmetic composition of the present invention is a suspension
  • a liquid diluent such as water, ethanol or propylene glycol
  • suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Microcrystalline cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.
  • the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, acethionate, an imidazolinium derivative, a methyltaurate, or a sarcosinate.
  • Fatty acid amide ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.
  • the cosmetic composition of the present invention may further contain an excipient including a fluorescent substance, a fungicide, a moisturizing agent, a moisturizer, a perfume, a perfume carrier, a protein, a solubilizer, a sugar derivative, a sunscreen agent, a vitamin, an emulsifier, a plant extract, and the like.
  • an excipient including a fluorescent substance, a fungicide, a moisturizing agent, a moisturizer, a perfume, a perfume carrier, a protein, a solubilizer, a sugar derivative, a sunscreen agent, a vitamin, an emulsifier, a plant extract, and the like.
  • an excipient including a fluorescent substance, a fungicide, a moisturizing agent, a moisturizer, a perfume, a perfume carrier, a protein, a solubilizer, a sugar derivative, a sunscreen agent, a vitamin, an emulsifier, a plant extract, and the like.
  • the present invention also provides a health functional food composition for improving skin whitening containing fermented coffee beans fermented with Lactobacillus curvatus strain as an active ingredient.
  • the fermented coffee bean of the present invention When used as a food additive, the fermented coffee bean may be added as it is or used with other food or food ingredients, and may be appropriately used according to a conventional method.
  • the mixed amount of the active ingredient can be suitably determined depending on the purpose of use (prevention, improvement, health or therapeutic treatment).
  • the fermented coffee beans of the present invention are added in an amount of 15 parts by weight or less, preferably 10 parts by weight or less based on the raw material in the manufacture of food or beverage.
  • the amount may be below the above range, and the active ingredient may be used in an amount above the above range because there is no problem in terms of safety. .
  • the fermented coffee beans may be used to produce processed foods having improved shelf life while modifying the characteristics of agricultural products, livestock products or aquatic products.
  • processed foods include, for example, sweets, beverages, alcoholic beverages, fermented foods, canned foods, milk processed foods, meat processed foods, noodles and the like.
  • Confections include biscuits, pies, bread, candy, jelly, gum, cereals (including meal substitutes such as grain flour).
  • Beverages include carbonated drinks, functional ion drinks, juices (eg, apples, pears, grapes, aloes, citrus fruits, peaches, carrots, tomato juices, etc.), Sikhye, and the like.
  • Alcoholic beverages include sake, whiskey, shochu, beer, liquor and fruit wine.
  • Fermented foods include soy sauce, miso, and red pepper paste.
  • Canned food includes canned seafood (e.g., tuna, mackerel, canned meat, canned seashells, etc.), canned animal products (e.g. beef, pork, chicken, turkey, etc.), canned produce (corn, peaches, pineapples, etc.).
  • Milk processed foods include cheese, butter, yogurt, and the like.
  • Processed meat products include pork cutlet, beef cutlet, chicken cutlet, sausage, sweet and sour pork, nuggets, pork bread and so on.
  • Noodles such as sealed packaging fresh noodles, are included.
  • the composition may be used in retort food, soups and the like.
  • the fermented coffee beans can be used to produce functional foods, health foods or health supplements.
  • Functional food, health food or dietary supplement means a food that provides a bioregulatory function, including a physiologically active ingredient in addition to the nutritional function, the fermented coffee beans of the present invention has a skin whitening effect, so functional food, health food or It can be used in the manufacture of dietary supplements.
  • the coffee beans were ground to a size of 0.05-0.5 mm and sterilized at 121 ° C. for 15 minutes.
  • the sterilized coffee beans are added to the sterilized water 10-100 times compared to the coffee beans, inoculated with vegetable lactic acid bacteria (1 ⁇ 3 OD) and then incubated in the liquid culture supernatant at 30-37 °C for 12-48 hours 0.45 ⁇ m After filtration through a filter was used as a sample.
  • Lactobacillus brevis Lactobacillus brevis, LB) 2 Lactobacillus sakei (LS) 3 Lactobacillus plantarum (LP) 4 Lactobacillus fermentum (LF) 5 Lactobacillus curvatus (LC) 6 Lactobacillus rhamnosus (LR) 7 Pediococcus acidilactici (PA) 8 Pediococcus pentosaceus (PP)
  • the reaction zone was mixed with 0.2 ml of substrate solution in which 10 mM L-DOPA was dissolved in 0.5 ml of sodium phosphate buffer (pH 6.8) at a concentration of 1/15 M and 0.1 ml of the sample. USA) 0.2 ml was added and reacted at 25 degreeC for 2 minutes, and the absorbance was measured at 475 nm.
  • the acidity was titrated by AOAC titration, 25 mL of distilled water was added after weighing the exact weight (about 10 mL) of the sample, and titrated with 0.1N NaOH until the pH was 8.4. At this time, the amount of 0.1N-NaOH consumed was recorded and converted into malic acid and expressed as the total acid content (%).
  • DPPH radical activity was added to 0.2 ml of solution, 0.8 ml of 0.4 mM DPPH (1,1 diphenyl-2-picryl-hydrazyl) solution was added for 10 minutes, and the absorbance was measured at 525 nm.
  • the formula, electron donating ability (%) 100- Activity was computed by [(sample absorbance / control absorbance) x100].
  • the results of comparing the tyrosinase activity after preparing the fermented coffee beans by changing the type of plant lactic acid bacteria inoculated when preparing the fermented coffee beans are shown in Table 3 below.
  • Blank means fermented coffee beans incubated for 24 hours without inoculating the strain.
  • the fermented coffee beans fermented with Lactobacillus Corbatus strains showed the lowest OD value compared to the fermented coffee beans prepared by fermenting with other strains, and showed the highest whitening activity.
  • Tyrosinase Activity (Optical Density) of Fermented Coffee Beans Strain type Tyrosinase activity Lactobacillus brevis (LB) 0.220 Lactobacillus sakei (LS) 0.220 Lactobacillus plantarum (LP) 0.220 Lactobacillus Permanent (LF) 0.228 Lactobacillus Cobatus (LC) 0.176 Lactobacillus rhamnosus (LR) 0.222 Pediocaucus Ashidi Lactissi (PA) 0.233 Blank 0.245
  • Lactobacillus curvatus strains suitable for use as cosmetic raw materials and capable of producing fermented coffee beans with excellent tyrosinase inhibitory activity were selected as the most suitable strains for coffee fermentation.
  • Lactobacillus curvatus strain is Lactobacillus curvatus SRCM101123 strain, which was deposited on November 16, 2016 to the Korea Microorganism Conservation Center (Accession Number: KCCM11933P).
  • Example 3 Total Polyphenol Content and DPPH Radical Scavenging Activity of Fermented Coffee Beans
  • the total polyphenol content and DPPH radical scavenging ability of fermented coffee beans prepared by varying incubation time after inoculating Lactobacillus curvatus SRCM101123 strain during the production of fermented coffee beans are shown in Table 4 below. Blank means fermented coffee beans incubated for 24 hours without inoculating the strain.
  • Example 4 of fermented coffee beans according to the culture method DPPH Radical Scavenging power

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Abstract

La présente invention concerne une composition cosmétique de blanchiment de la peau et une composition alimentaire naturelle fonctionnelle, destinées à améliorer le blanchiment de la peau, contenant des fèves de café fermentées avec une souche de Lactobacillus curvatus utilisées comme principe actif. Les fèves de café fermentées selon la présente invention présentent une excellente activité inhibitrice de la tyrosinase, et peuvent ainsi être utilisées efficacement en tant que produits cosmétiques fonctionnels et aliments naturels fonctionnels pour blanchir la peau.
PCT/KR2017/013389 2016-11-30 2017-11-23 Composition de blanchiment de la peau contenant des fèves de café fermentées utilisées comme principe actif WO2018101673A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2016-0161086 2016-11-30
KR1020160161086A KR101783728B1 (ko) 2016-11-30 2016-11-30 발효 커피 원두를 유효성분으로 포함하는 피부 미백용 조성물

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WO2018101673A2 true WO2018101673A2 (fr) 2018-06-07
WO2018101673A3 WO2018101673A3 (fr) 2018-08-09

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111134199A (zh) * 2020-02-20 2020-05-12 杭州九阳豆业有限公司 一种无豆腥味发酵豆浆的制备方法及制得的无豆腥味发酵豆浆

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Publication number Priority date Publication date Assignee Title
KR20190064695A (ko) 2017-11-30 2019-06-11 신라대학교 산학협력단 커피 추출물을 유효성분으로 하는 피부 주름 개선 또는 예방용 조성물

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JPH06100391A (ja) * 1992-08-18 1994-04-12 Heiwa Tsusho Kk コーヒー豆搾り滓の発酵処理方法
JP5791009B2 (ja) * 2008-12-22 2015-10-07 アサヒグループホールディングス株式会社 乳酸菌およびそれらを用いた飲食物又は化粧品
KR101045310B1 (ko) * 2009-07-31 2011-06-29 (주)에이씨티 유산균 발효 커피추출물을 함유하는 화장료 조성물 제조방법
FR2953408B1 (fr) * 2009-12-08 2013-02-08 Oreal Microorganismes probiotiques a titre d'actif pour l'eclat du teint de la peau
JP5611186B2 (ja) 2010-12-30 2014-10-22 花王株式会社 セラミド産生促進剤の製造方法
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111134199A (zh) * 2020-02-20 2020-05-12 杭州九阳豆业有限公司 一种无豆腥味发酵豆浆的制备方法及制得的无豆腥味发酵豆浆

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KR101783728B1 (ko) 2017-10-10
WO2018101673A3 (fr) 2018-08-09

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