WO2018095004A1 - 医用抗菌织物及其制备方法 - Google Patents

医用抗菌织物及其制备方法 Download PDF

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WO2018095004A1
WO2018095004A1 PCT/CN2017/086496 CN2017086496W WO2018095004A1 WO 2018095004 A1 WO2018095004 A1 WO 2018095004A1 CN 2017086496 W CN2017086496 W CN 2017086496W WO 2018095004 A1 WO2018095004 A1 WO 2018095004A1
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medical
fabric
antibacterial
quaternary ammonium
ammonium salt
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French (fr)
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包磊
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包磊
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    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
    • D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
    • D06M13/152—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen having a hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
    • D06M13/50—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with organometallic compounds; with organic compounds containing boron, silicon, selenium or tellurium atoms
    • D06M13/51—Compounds with at least one carbon-metal or carbon-boron, carbon-silicon, carbon-selenium, or carbon-tellurium bond
    • D06M13/513—Compounds with at least one carbon-metal or carbon-boron, carbon-silicon, carbon-selenium, or carbon-tellurium bond with at least one carbon-silicon bond
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic

Definitions

  • the invention belongs to the technical field of treatment, and in particular relates to a medical antibacterial fabric and a preparation method thereof.
  • Textiles have a series of characteristics, such as softness, elasticity, strength, etc., especially for medical requirements, not allergic, non-carcinogenic, non-toxic, anti-static, fatigue-resistant, biocompatible, fireproof, color can not be irritating.
  • characteristics such as softness, elasticity, strength, etc.
  • non-woven fabric is widely used in medical textiles. It is a new generation of environmentally friendly materials, which are characterized by moisture resistance, breathability, flexibility, light weight, non-combustible, non-toxic and non-irritating, low price and convenient production.
  • the antibacterial properties of textiles such as non-woven fabrics are such that they contain an antibacterial agent.
  • Antibacterial agents are classified into inorganic antibacterial agents, organic antibacterial agents and natural antibacterial agents, each of which has its limitations. Among them, the natural antibacterial agent has relatively poor antibacterial effect, and the organic antibacterial agent is easy to fall off.
  • Inorganic antibacterial agents are represented by silver-based particles, broad-spectrum sterilization and strong bactericidal effect. Among them, nano-silver, which is emerging in recent years, is representative, but nano-silver antibacterial agents may cause unknown harm due to their small particle size. It is forbidden to use in Europe and America.
  • Existing methods for preparing antibacterial textiles generally employ a dipping method in which a textile such as a non-woven fabric is immersed in In the solution in which the antibacterial component is dissolved, after a while, it is taken out and dried to obtain a nonwoven fabric carrying an antibacterial substance.
  • Silver impregnating substances are often used for the impregnation method.
  • the impregnation method causes the antibacterial substance to not adhere well to textiles such as non-woven fabrics, and the antibacterial substance is easily detached.
  • the dipping method requires a large amount of antibacterial substance to be consumed, and the economy is poor.
  • the object of the present invention is to overcome the above-mentioned deficiencies of the prior art, and to provide a medical antibacterial fabric and a preparation method thereof, which overcome the existing antibacterial agent antibacterial agent which is easy to fall off, which may cause harm to the human body, and the economical preparation method thereof is poor. technical problem.
  • a method of preparing a medical antimicrobial fabric comprises the following steps:
  • the medical fabric is immersed in a solution of 4-(2-aminoethyl)-1,2-benzenediol hydrochloride, and then dried;
  • the surface of the medical fabric after the immersion treatment is sprayed with a silicone quaternary ammonium salt solution, followed by drying treatment.
  • a medical antimicrobial fabric comprises a medical fabric and 4-(2-aminoethyl)-1,2-benzenediol hydrochloride and an effective amount of a silicone quaternary ammonium salt contained on the medical fabric,
  • the mass ratio of the 4-(2-aminoethyl)-1,2-benzenediol hydrochloride to the organosilicon quaternary ammonium salt per unit area of the medical fabric is (1-3):8.
  • the method for preparing the medical antibacterial fabric of the present invention first impregnates the medical fabric with a solution of 4-(2-aminoethyl)-1,2-benzenediolate hydrochloride, so that 4-(2-aminoethyl)
  • the base-1,2-benzenediol salt is firmly bonded to the surface of the medical fabric, and then the organosilicon quaternary ammonium salt is sprayed, so that the method of the invention has the following technical effects:
  • the organosilicon quaternary ammonium salt can be firmly bonded to the medical fabric by 4-(2-aminoethyl)-1,2-benzenediol hydrochloride, so that the prepared medical antibacterial fabric has a sustained and stable antibacterial effect. , effectively avoiding the shortage of the existing antibacterial agent for medical antibacterial fabrics;
  • silicone quaternary ammonium salt bacteriostatic agent has good comprehensive performance, non-toxic, harmless and environmentally friendly. It does not cause damage to the skin of the patient when it comes into contact with the patient's skin. It avoids the possibility that the nano-silver antibacterial agent may be unknown due to its small particle size. harm;
  • the coating of the organosilicon quaternary ammonium salt antibacterial agent by spraying method improves the utilization rate of the antibacterial agent, and avoids the problem that the existing dipping method consumes a large amount of antibacterial substances;
  • the prepared medical antibacterial fabric not only has a sustained and safe antibacterial effect, but also can be effective. Avoid damage to medical fabric fibers, maintain the softness, surface comfort and mechanical properties of medical fabrics;
  • the preparation method of the invention has simple process and high operability, and the prepared medical antibacterial fabric has stable performance and low economic cost.
  • the medical antibacterial fabric of the invention synergistically acts with the organosilicon quaternary ammonium salt of 4-(2-aminoethyl)-1,2-benzenediol hydrochloride to make the silicone quaternary ammonium salt antibacterial agent firmly bonded to the medical fabric. It is resistant to repeated washing, has good antibacterial effect, is safe, non-toxic and environmentally friendly, and has good softness, surface comfort and mechanical properties.
  • Example 1 is an antibacterial effect diagram of the medical antibacterial fabric provided in Example 1-3 of the present invention and the original non-woven fabric provided in Comparative Example 1.
  • the graph ac is the antibacterial effect diagram of the medical antibacterial fabric provided in Examples 1-3, respectively.
  • Figure d is an antibacterial effect diagram of the original nonwoven fabric provided in Comparative Example 1.
  • FIG. 2 is an antibacterial diagram of a medical antibacterial fabric provided in Example 2 of the present invention and an antibacterial agent antibacterial agent provided in Comparative Example 2 before and after the experiment; wherein, Figure e is an antibacterial diagram of the medical antibacterial fabric of Example 2 before water washing, Figure f is an antibacterial diagram of the medical antibacterial fabric of Example 2 after water washing, Figure g is an antibacterial diagram of the antibacterial fabric of Comparative Example 2 before water washing, and Figure h is an antibacterial diagram of the antibacterial fabric of Comparative Example 2 after water washing.
  • the present invention provides a method for preparing a medical antibacterial fabric which is firmly and safely combined with an antibacterial agent.
  • the preparation method of the embodiment of the invention comprises the following steps:
  • Step S01 immersing the medical fabric in a solution of 4-(2-aminoethyl)-1,2-benzenediol hydrochloride solution, followed by drying;
  • Step S02 spraying the surface of the medical fabric after the immersion treatment on the silicone quaternary ammonium salt solution, followed by drying.
  • the immersion treatment is a combination of 4-(2-aminoethyl)-1,2-benzenediol hydrochloride on a medical fabric.
  • the concentration of the 4-(2-aminoethyl)-1,2-benzenediol hydrochloride solution is from 5 mg to 25 mg/ml.
  • the 4-(2- The concentration of the aminoethyl)-1,2-benzenediol hydrochloride solution may be, but not limited to, only 10 mg/ml, 20 mg/ml, and the like.
  • the concentration of 4-(2-aminoethyl)-1,2-benzenediol hydrochloride solution in this concentration range not only enables 4-(2-aminoethyl)-1,2-benzenediol hydrochloride
  • the salt can be uniformly bonded to the surface of the medical fabric, and the medical fabric has an appropriate amount of 4-(2-aminoethyl)-1,2-benzenediol hydrochloride, which can effectively ensure the antibacterial of the organosilicon quaternary ammonium salt.
  • the content of the agent, and the solidity of the combination of the silicone quaternary ammonium salt antibacterial agent is ensured.
  • the immersion treatment time should be sufficient on the premise that the medical fabric fibers are adversely affected due to excessive immersion time, as in one embodiment, the immersion treatment time is 10-30 min.
  • the immersion treatment is in the absence of oxygen. Performed in an environment such as an environment filled with a protective gas, such as in a nitrogen-filled environment.
  • the drying treatment in the step S01 is to remove the solvent.
  • the drying process has a temperature of 30-40 °C.
  • the solvent removed can be, but not just water.
  • the medical fabric in the step S01 is but not only a medical woven fabric or Medical non-woven fabrics.
  • the corresponding medical articles prepared from the cloth such as general medical textiles and advanced medical textiles, are included.
  • step S02 the surface of the immersed medical fabric prepared by the step S01 is sprayed with a silicone quaternary ammonium salt solution for spraying the antibacterial agent on the medical fabric, so that the silicone quaternary ammonium salt antibacterial agent is Under the action of 4-(2-aminoethyl)-1,2-benzenediol hydrochloride, it is firmly bonded to medical fabrics.
  • the phenolic hydroxyl group in 4-(2-aminoethyl)-1,2-benzenediol is a strongly polar group which can form a strong bond with a group in the organosilicon quaternary ammonium salt, thereby The silicone quaternary ammonium salt is firmly bonded to the medical fabric, thereby ensuring that the silicone quaternary ammonium salt is firmly attached to the medical fabric.
  • the organosilicon quaternary ammonium salt solution is from 45 mg to 85 mg/ml.
  • concentration of the organosilicon quaternary ammonium salt solution By controlling the concentration of the organosilicon quaternary ammonium salt solution, the distribution of the organosilicon quaternary ammonium salt on the medical fabric is ensured and the content is ensured.
  • after spraying it is preferred to have a silicone quaternary ammonium salt content of from 0.05 to 0.5 g/m 2 in the medical woven unit area.
  • the organosilicon quaternary ammonium salt is 3-(trimethoxysilyl)propyldimethyloctadecyl quaternary ammonium chloride.
  • the selected silicone quaternary ammonium salt has a long lasting antibacterial effect.
  • the finished fabric not only has excellent antibacterial properties, but also can be firmly bonded to medical fabrics under the action of 4-(2-aminoethyl)-1,2-benzenediol hydrochloride.
  • the prepared medical antibacterial fabric also has good water absorption and sweat absorption, softness, smoothness, resilience, antistatic property and anti-pollution property, and has no irritation and carcinogenic effect on human skin, and all indexes are in line with antibacterial at home and abroad. Textile requirements.
  • the drying treatment in the step S02 is to remove the solvent.
  • the drying treatment temperature is 30-40 ° C, and the drying treatment temperature in this step may be the same as or different from the drying treatment temperature in the above step S02.
  • the solvent from which the drying treatment of this step is removed may be, but not limited to, water.
  • the medical antibacterial fabric prepared by the method for preparing the medical antibacterial fabric contains 4-(2-aminoethyl)-1,2-benzenediol hydrochloride and an antibacterial agent organosilicon quaternary ammonium salt, and the organosilicon season
  • the ammonium salt is firmly bonded to the medical fabric under the strong action of 4-(2-aminoethyl)-1,2-benzenediol hydrochloride, so that the medical antibacterial fabric has a sustained and stable antibacterial effect, and is safe and non-toxic. Harmless and environmentally friendly, and keep Medical fabric softness and surface comfort as well as mechanical properties.
  • the preparation method improves the utilization rate of the antibacterial agent, has high operability, and the prepared medical antibacterial fabric has stable performance and low economic cost.
  • the embodiment of the invention further provides a medical antibacterial fabric.
  • the medical antibacterial fabric comprises a medical fabric and 4-(2-aminoethyl)-1,2-benzenediol hydrochloride and an effective amount of a silicone quaternary ammonium salt contained on the medical fabric,
  • the mass ratio of the 4-(2-aminoethyl)-1,2-benzenediol hydrochloride to the organosilicon quaternary ammonium salt per unit area of the medical fabric is (1-3):8.
  • the medical antibacterial fabric of the embodiment of the invention synergizes with the organosilicon quaternary ammonium salt by the synergistic action of 4-(2-aminoethyl)-1,2-benzenediol hydrochloride and the organosilicon quaternary ammonium salt, so that the silicone quaternary ammonium salt antibacterial agent is firmly combined. It is resistant to repeated washing on medical fabrics, has good antibacterial effect, is safe, non-toxic and environmentally friendly, and has good softness, surface comfort and mechanical properties.
  • the organosilicon quaternary ammonium salt is selected from the above-mentioned method for preparing a medical antibacterial fabric, and 3-(trimethoxysilyl)propyldimethyloctadecyl quaternary ammonium chloride is used.
  • An effective dosage of the silicone quaternary ammonium salt is to be understood to be an amount at least sufficient to achieve the clinical significance of the antibacterial effect.
  • the above-mentioned medical antibacterial fabric, its preparation method and the like are exemplified by a plurality of examples.
  • the medical antibacterial fabric is prepared by the following method:
  • a 6.5% organosilicon quaternary ammonium salt solution was sprayed onto the nonwoven fabric by a spray method, and dried at 30 to 40 degrees Celsius for 30 minutes to obtain an antibacterial nonwoven fabric having a stable antibacterial substance.
  • the mass ratio of 4-(2-aminoethyl)-1,2-benzenediol hydrochloride and the organosilicon quaternary ammonium salt contained in the antibacterial nonwoven fabric was 1:8.
  • the medical antibacterial fabric is prepared by the following method:
  • An antibacterial nonwoven fabric having a stable antibacterial substance.
  • the mass ratio of 4-(2-aminoethyl)-1,2-benzenediol hydrochloride and the organosilicon quaternary ammonium salt contained in the antibacterial nonwoven fabric was 2.5:8.
  • the medical antibacterial fabric is prepared by the following method:
  • a 5.5% organosilicon quaternary ammonium salt solution was sprayed onto the nonwoven fabric by a spray method, and dried at 30 to 40 degrees Celsius for 30 minutes to obtain an antibacterial nonwoven fabric having a stable antibacterial substance.
  • the mass ratio of 4-(2-aminoethyl)-1,2-benzenediol hydrochloride and the organosilicon quaternary ammonium salt contained in the antibacterial nonwoven fabric was 3:8.
  • the medical antibacterial fabric is prepared by the following method:
  • a 6.5% organosilicon quaternary ammonium salt solution was sprayed onto the nonwoven fabric by a spray method, and dried at 30 to 40 degrees Celsius for 30 minutes to obtain an antibacterial nonwoven fabric having a stable antibacterial substance.
  • the mass ratio of 4-(2-aminoethyl)-1,2-benzenediol hydrochloride and the organosilicon quaternary ammonium salt contained in the antibacterial nonwoven fabric was 1:8.
  • the nonwoven fabric of Example 1 was directly provided, and the step of impregnating and spraying the antibacterial agent was not performed.
  • Example 2 Refer to the preparation method of the medical antibacterial fabric of Example 1, except that the step of impregnating 4-(2-aminoethyl)-1,2-benzenediol hydrochloride is directly carried out at a concentration of 5.5%.
  • the organosilicon quaternary ammonium salt solution is sprayed on the nonwoven fabric by a spray method, and dried at 30 to 40 degrees Celsius for 30 minutes to obtain an antibacterial nonwoven fabric having a stable antibacterial substance.
  • the antibacterial properties of the medical antibacterial fabrics provided in Examples 1-4 and the medical fabrics provided in Comparative Example 1 were tested using the HALO antibacterial halo (circle) test method, wherein the test results of Examples 1, 2, and 3 are shown in FIG.
  • the test results of Example 2 were similar to those of Example 4. It can be seen from Fig. 1 that the medical antibacterial fabrics provided in Examples 1-3 have antibacterial properties, and the antibacterial rate is tested by the modified Quinn method. The antibacterial rates of the medical antibacterial fabrics provided in Examples 1-3 are all above 95%.
  • the original nonwoven fabric of Comparative Example 1 did not have antibacterial properties.
  • the antibacterial property of the medical antibacterial fabric provided in Example 4 was similar to that of Example 1.
  • Example 1 In order to compare the original nonwoven fabric without antibacterial modification in Example 1, it was shown to have antibacterial properties.
  • the bacteriostasis rate was tested by modified quinine method, and the inhibition rates of the four kinds of non-woven fabrics were all above 95%.
  • the medical antibacterial fabrics provided in Examples 1-4 and the antibacterial fabrics provided in Comparative Example 2 were subjected to stability experiments.
  • the specific method is as follows: After each antibacterial fabric was washed with water for 10 times, the antibacterial experiment as in the above 1 was carried out.
  • the antibacterial pattern of the antibacterial fabric of Example 2 and the antibacterial fabric of Comparative Example 2 before and after water washing is shown in Fig. 2.
  • the antibacterial fabric of Example 2 still had antibacterial properties after 10 times of water washing.
  • the antibacterial fabric of Comparative Example 2 hardly had antibacterial properties after 10 times of water washing.

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Abstract

一种医用抗菌织物及其制备方法，制备步骤包括将医用织物于4-(2-氨基乙基)-1,2-苯二酚盐酸盐溶液中浸渍处理后，进行干燥处理的步骤；在被浸渍处理后的所述医用织物表面进行喷涂有机硅季铵盐溶液，后进行干燥处理的步骤。该医用抗菌织物具有持续稳定的抗菌效果，而且安全无毒无害环保，并保持了医用织物柔软性和表面舒适性以及力学性能。该制备方法提高了抗菌剂的使用率，可操作性高，制备的医用抗菌织物性能稳定，而且经济成本低。

Description

医用抗菌织物及其制备方法 技术领域
本发明属于治疗技术领域，具体涉及一种医用抗菌织物及其制备方法。
背景技术
纺织品具有一系列特性，如柔软性、弹性、强度等，特别是用于医疗方面要求不过敏、不致癌、无毒、抗静电、耐疲劳、生物兼容、防火、颜色不能具有刺激性。近年来，世界各地的研究工作均基于上述特性，迅速地将纺织品推广到医学领域。
其中，无纺布是被广泛用于医疗的纺织品，其是新一代环保材料，具有防潮、透气、柔韧、质轻、不助燃、无毒无刺激性、价格低廉、生产方便等特点。
通常情况下，人的皮肤表面存在着大量的微生物，其中有些是对人体有益的菌，而有些则是致病菌，这些微生物菌群在人体表皮上保持着数量上的平衡协调，一般不会对人体造成危害，但一旦这种平衡被打破，造成菌群失调，少量致病菌就会大量繁殖，并通过皮肤、呼吸道、消化道等对人体健康造成危害，因此，所有的纺织品如无纺布用于医疗领域首先需要其具有抗菌效果，这样才能达到抑制危害细菌生长的作用，其次抗菌效果又不能过于强大，防止破坏正常皮肤上的菌群平衡。
纺织品如无纺布的抗菌性能是使其含有抗菌剂。抗菌剂分为无机抗菌剂、有机抗菌剂和天然抗菌剂，每一种都有其局限性。其中，天然抗菌剂抗菌效果相对较差，有机抗菌剂易脱落。无机抗菌剂以银系粒子为代表，广谱杀菌且杀菌效果强，其中又以近年来兴起的纳米银为代表，但纳米银抗菌剂因其粒径很小可能造成未知的危害，其在美国等欧美国家禁止使用。
现有制备抗菌纺织品的方法一般采用浸渍法，即把纺织品如无纺布浸没于 溶有抗菌组分的溶液中，一段时间后，取出烘干，得到载有抗菌物质的无纺布。浸渍法多采用银系抗菌物质。但是该浸渍法会造成抗菌物质不能很好的粘合在纺织品如无纺布上，抗菌物质易脱离。而且该浸渍法需要消耗大量抗菌物质，经济性差。
发明内容
本发明的目的在于克服现有技术的上述不足，提供一种医用抗菌织物及其制备方法，以克服现有抗菌织物抗菌剂易脱落，对人体造成可能未知的危害，以及其制备方法经济性差的技术问题。
为了实现上述发明目的，本发明的一方面，提供了一种医用抗菌织物的制备方法。本发明医用抗菌织物的制备方法包括如下步骤：
将医用织物于4-(2-氨基乙基)-1,2-苯二酚盐酸盐溶液中浸渍处理后，进行干燥处理；
在被浸渍处理后的所述医用织物表面进行喷涂有机硅季铵盐溶液，后进行干燥处理。
本发明的另一方面，提供了一种医用抗菌织物。所述医用抗菌织物包括医用织物和在所述医用织物上含有的4-(2-氨基乙基)-1,2-苯二酚盐酸盐和有效剂量的有机硅季铵盐，在所述医用织物单位面积内，所述4-(2-氨基乙基)-1,2-苯二酚盐酸盐和有机硅季铵盐的质量比为(1-3)：8。
与现有技术相比，本发明医用抗菌织物的制备方法先用4-(2-氨基乙基)-1,2-苯二酚盐酸盐溶液浸渍医用织物，使得4-(2-氨基乙基)-1,2-苯二酚盐酸盐牢固结合在医用织物表面，然后喷涂有机硅季铵盐，使得本发明方法具有以下技术效果：
1.该有机硅季铵盐能够通过4-(2-氨基乙基)-1,2-苯二酚盐酸盐牢固的粘合医用织物上，使得制备的医用抗菌织物具有持续稳定的抗菌效果，有效避免了现有医用抗菌织物抗菌剂易脱落的不足；
2.选用有机硅季铵盐抑菌剂综合性能好，无毒无害又环保，与接触患者皮肤接触不患者皮肤造成伤害，避免了如纳米银抗菌剂因其粒径很小可能造成未知的危害；
3.另外，采用喷涂法涂覆有机硅季铵盐抗菌剂，提高了抗菌剂的使用率，避免了现有浸渍法消耗大量抗菌物质的问题；
4.采用4-(2-氨基乙基)-1,2-苯二酚盐酸盐与有机硅季铵盐的协同作用，使得制备的医用抗菌织物不仅具有持续安全的抗菌效果，而且能够有效避免对医用织物纤维的损伤，保持医用织物的柔软性和表面舒适性以及力学性能；
5.本发明制备方法工艺简单，可操作性高，制备的医用抗菌织物性能稳定，而且经济成本低。
本发明医用抗菌织物通过4-(2-氨基乙基)-1,2-苯二酚盐酸盐与有机硅季铵盐的协同作用，使得有机硅季铵盐抗菌剂牢固结合在医用织物上，耐反复洗涤，抗菌效果好，安全无毒无害又环保，而且柔软性和表面舒适性以及力学性好。
附图说明
下面将结合附图及实施例对本发明作进一步说明，附图中：
图1为本发明实施例1-3提供的医用抗菌织物和对比实施例1提供的原无纺布的抗菌效果图；其中，图a-c分别为实施例1-3提供的医用抗菌织物抗菌效果图，图d为对比实施例1提供的原无纺布抗菌效果图；
图2为本发明实施例2提供的医用抗菌织物和对比实施例2提供的抗菌织物抗菌剂结合稳定性实验前后的抗菌图；其中，图e为实施例2医用抗菌织物水洗前的抗菌图、图f为实施例2医用抗菌织物水洗后的抗菌图，图g为对比实施例2抗菌织物水洗前的抗菌图、图h为对比实施例2抗菌织物水洗后的抗菌图。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合附图及实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。
本发明实例提供了一种抗菌剂结合牢固，且安全的医用抗菌织物的制备方法。本发明实施例制备方法包括如下步骤：
步骤S01：将医用织物于4-(2-氨基乙基)-1,2-苯二酚盐酸盐溶液中浸渍处理后，进行干燥处理；
步骤S02：在被浸渍处理后的所述医用织物表面进行喷涂有机硅季铵盐溶液，后进行干燥处理。
具体地，上述步骤S01中，浸渍处理是为4-(2-氨基乙基)-1,2-苯二酚盐酸盐结合在医用织物上。在一实施例中，所述4-(2-氨基乙基)-1,2-苯二酚盐酸盐溶液的浓度为5mg-25mg/ml，在具体实施例中，该4-(2-氨基乙基)-1,2-苯二酚盐酸盐溶液的浓度可以但不仅仅为10mg/ml、20mg/ml等。将4-(2-氨基乙基)-1,2-苯二酚盐酸盐溶液浓度控制在该浓度范围不仅能够使得4-(2-氨基乙基)-1,2-苯二酚盐酸盐能够均匀结合在医用织物表面，而且使得医用织物上还有适量的4-(2-氨基乙基)-1,2-苯二酚盐酸盐，这样不仅能够有效保证有机硅季铵盐抗菌剂的含量，而且保证了有机硅季铵盐抗菌剂结合的牢固性。另外，该浸渍处理时间在对医用织物纤维由于浸渍时间过长造成不利影响的前提下应该是充分的，如在一实施例中，所述浸渍处理的时间为10-30min。
为了保证4-(2-氨基乙基)-1,2-苯二酚盐酸盐在本发明实施例中的性能及其作用的稳定性，在一实施例中，该浸渍处理是在无氧环境中进行的，如充满保护性气体的环境，如充满氮气的环境中进行。
该步骤S01中的干燥处理理所当然的是除去溶剂。在一实施例中，所述干燥处理的温度为30-40℃。被除去的溶剂可以是但不仅仅是水。
在上述各实施例中，该步骤S01中的所述医用织物为但不仅仅医用织布或 者医用无纺布。当然包括由该布制备的相应医用品，如普通医用纺织品和高级医用纺织品等。
上述步骤S02中，对由步骤S01制备的被浸渍处理后的所述医用织物表面喷涂有机硅季铵盐溶液的目的是为了将抗菌剂喷涂在医用织物上，使得有机硅季铵盐抗菌剂在4-(2-氨基乙基)-1,2-苯二酚盐酸盐的作用下，牢固的结合在医用织物上。4-(2-氨基乙基)-1,2-苯二酚中酚羟基是一种具有强极性的基团，可以与有机硅季铵盐中的基团形成强有力的键，从而将有机硅季铵盐牢固粘合在医用织物上，从而保证了有机硅季铵盐牢固附着在医用织物上。
在一实施例中，所述有机硅季铵盐溶液为45mg-85mg/ml。通过对有机硅季铵盐溶液浓度的控制，保证有机硅季铵盐在医用织物上的分布均匀，并保证其含量。在另一实施例中，经喷涂后，在医用织单位面积内，优选的使得有机硅季铵盐的含量为0.05-0.5g/m2。在具体实施例中，所述有机硅季铵盐为3-(三甲氧基硅烷基)丙基二甲基十八烷基季铵氯化物。该选用的有机硅季铵盐具有持久的抗菌效果。整理后的织物不仅具有优良的抗菌性能，而且能在4-(2-氨基乙基)-1,2-苯二酚盐酸盐的作用下牢固的结合在医用织物。另外使得制备的医用抗菌织物还具备良好的吸水吸汗性、柔软性、平滑性、回弹性、防静电性和抗污染性，对人体皮肤无刺激和致癌作用,各项指标都符合国内外对抗菌纺织品的要求。
该步骤S02中的干燥处理理所当然的是除去溶剂。在一实施例中，所述干燥处理的温度为30-40℃，本步骤的干燥处理温度与上述步骤S02中的干燥处理温度可以相同也可以不相同。本步骤的干燥处理被除去的溶剂可以是但不仅仅是水。
由上述可知，上述医用抗菌织物的制备方法制备的医用抗菌织物含有4-(2-氨基乙基)-1,2-苯二酚盐酸盐和抗菌剂有机硅季铵盐，且有机硅季铵盐在4-(2-氨基乙基)-1,2-苯二酚盐酸盐牢固的作用下牢固的结合在医用织物上，使得医用抗菌织物具有持续稳定的抗菌效果，而且安全无毒无害又环保，并保持 了医用织物柔软性和表面舒适性以及力学性能。另外该制备方法提高了抗菌剂的使用率，可操作性高，制备的医用抗菌织物性能稳定，而且经济成本低。
相应地，在上述医用抗菌织物制备方法的基础上，本发明实施例还提供了一种医用抗菌织物。所述医用抗菌织物包括医用织物和在所述医用织物上含有的4-(2-氨基乙基)-1,2-苯二酚盐酸盐和有效剂量的有机硅季铵盐，在所述医用织物单位面积内，所述4-(2-氨基乙基)-1,2-苯二酚盐酸盐和有机硅季铵盐的质量比为(1-3)：8。这样，本发明实施例医用抗菌织物通过4-(2-氨基乙基)-1,2-苯二酚盐酸盐与有机硅季铵盐的协同作用，使得有机硅季铵盐抗菌剂牢固结合在医用织物上，耐反复洗涤，抗菌效果好，安全无毒无害又环保，而且柔软性和表面舒适性以及力学性好。
其中，有机硅季铵盐如上文医用抗菌织物制备方法中所述的，选用3-(三甲氧基硅烷基)丙基二甲基十八烷基季铵氯化物。该有机硅季铵盐的有效剂量应当理解成至少足以能够实现抗菌效果临床意义的量。
以下通过多个实施例来举例说明上述医用抗菌织物及其制备方法等方面。
实施例1
一种医用抗菌织物及其制备方法。该医用抗菌织物由下述方法制备获得：
将1g 4-(2-氨基乙基)-1,2-苯二酚盐酸盐在无氧条件下溶于100ml去离子水，通过浸渍将其附着在直径为10cm的亲水PP(丙纶)无纺布上，静置10min后，将浓度为6.5％的有机硅季铵盐溶液通过喷雾法喷涂在无纺布上，之后将其取出置于30～40摄氏度下烘干2h，再将浓度为6.5％的有机硅季铵盐溶液通过喷雾法喷涂在无纺布上，在30～40摄氏度下烘干30min，即得到具有稳定抗菌物质的抗菌无纺布。其中，抗菌无纺布所含的4-(2-氨基乙基)-1,2-苯二酚盐酸盐和有机硅季铵盐的质量比为1：8。
实施例2
一种医用抗菌织物及其制备方法。该医用抗菌织物由下述方法制备获得：
将2g 4-(2-氨基乙基)-1,2-苯二酚盐酸盐在无氧条件下溶于100ml去离子 水，通过浸渍将其附着在直径为10cm的亲水PP(丙纶)无纺布上，静置10min后，将浓度为6.5％的有机硅季铵盐溶液通过喷雾法喷涂在无纺布上，之后将其取出置于30～40摄氏度下烘干2h，再将浓度为6.5％的有机硅季铵盐溶液通过喷雾法喷涂在无纺布上，在30～40摄氏度下烘干30min，即得到具有稳定抗菌物质的抗菌无纺布。其中，抗菌无纺布所含的4-(2-氨基乙基)-1,2-苯二酚盐酸盐和有机硅季铵盐的质量比为2.5：8。
实施例3
一种医用抗菌织物及其制备方法。该医用抗菌织物由下述方法制备获得：
将2g 4-(2-氨基乙基)-1,2-苯二酚盐酸盐在无氧条件下溶于100ml去离子水，通过浸渍将其附着在直径为10cm的亲水PP(丙纶)无纺布上，静置10min后，将浓度为5.5％的有机硅季铵盐溶液通过喷雾法喷涂在无纺布上，之后将其取出置于30～40摄氏度下烘干2h，再将浓度为5.5％的有机硅季铵盐溶液通过喷雾法喷涂在无纺布上，在30～40摄氏度下烘干30min，即得到具有稳定抗菌物质的抗菌无纺布。其中，抗菌无纺布所含的4-(2-氨基乙基)-1,2-苯二酚盐酸盐和有机硅季铵盐的质量比为3：8。
实施例4
一种医用抗菌织物及其制备方法。该医用抗菌织物由下述方法制备获得：
将1g 4-(2-氨基乙基)-1,2-苯二酚盐酸盐在无氧条件下溶于100ml去离子水，通过浸渍将其附着在直径为10cm的亲水PET(涤纶)无纺布上，静置10min后，将浓度为6.5％的有机硅季铵盐溶液通过喷雾法喷涂在无纺布上，之后将其取出置于30～40摄氏度下烘干2h，再将浓度为6.5％的有机硅季铵盐溶液通过喷雾法喷涂在无纺布上，在30～40摄氏度下烘干30min，即得到具有稳定抗菌物质的抗菌无纺布。其中，抗菌无纺布所含的4-(2-氨基乙基)-1,2-苯二酚盐酸盐和有机硅季铵盐的质量比为1：8。
对比实施例1
直接提供实施例1中的无纺布，不对其浸渍和喷涂抗菌剂的步骤。
对比实施例2
参照实施例1中医用抗菌织物的制备方法，不同之处在于，不经过浸渍4-(2-氨基乙基)-1,2-苯二酚盐酸盐的步骤，直接将浓度为5.5％的有机硅季铵盐溶液通过喷雾法喷涂在无纺布上，在30～40摄氏度下烘干30min，得到具有稳定抗菌物质的抗菌无纺布。
相关性能测试实验：
1.抗菌实验：
采用HALO抑菌晕(圈)实验法测试实施例1-4提供的医用抗菌织物和对比实施例1提供的医用织物的抗菌性，其中，实施例1、2、3测试结果如图1所示，实施例2的测试结果与实施例4近似。由图1可知，实施例1-3提供的医用抗菌织物均具有抗菌性，采用改良奎因法测试抑菌率，实施例1-3提供的医用抗菌织物的抑菌率均在95％以上。对比实施例1原无纺布不具备抗菌性能。实施例4提供的医用抗菌织物抗菌性能与实施例1近似。
为对比实施例1中的没有抗菌改性的原无纺布，表明其具有抗菌性。采用改良奎因法测试抑菌率，四种无纺布的抑菌率均在95％以上。
2.抗菌剂结合稳定性实验：
将实施例1-4提供的医用抗菌织物和对比实施例2提供的抗菌织物进行稳定性实验。具体方法如下：将各抗菌织物经过水洗10次之后再进行如上述1中抗菌实验。其中实施例2的抗菌织物和对比实施例2的抗菌织物水洗前后的抗菌图如图2所示。由图2e和f对比可知，实施例2的抗菌织物经过10次水洗之后，依然具有抗菌性能。而对比图2g和h可知，对比实施例2的抗菌织物经过10次水洗之后，其几乎不具备抗菌性能。另外，将实施例1和3、4的抗菌织物按照实施例2的方式进行稳定性实验后，得知实施例1和3、4的抗菌织物的稳定性实验结果与实施例2实验结果相似，经水洗后依然具有抗菌性，因此本实施例医用抗菌织物所含的抗菌剂与织物结合稳定。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发 明的精神和原则之内所作的任何修改、等同替换和改进等，均应包括在本发明的保护范围之内。

Claims (10)

  1. 一种医用抗菌织物的制备方法，包括如下步骤：
    将医用织物于4-(2-氨基乙基)-1,2-苯二酚盐酸盐溶液中浸渍处理后，进行干燥处理；
    在被浸渍处理后的所述医用织物表面进行喷涂有机硅季铵盐溶液，后进行干燥处理。
  2. 根据权利要求1所述的制备方法，其特征在于：所述4-(2-氨基乙基)-1,2-苯二酚盐酸盐溶液的浓度为5mg-25mg/ml。
  3. 根据权利要求1所述的制备方法，其特征在于：所述浸渍处理的时间为10-30min。
  4. 根据权利要求1-3任一所述的制备方法，其特征在于：所述浸渍处理是在无氧条件下进行。
  5. 根据权利要求1所述的制备方法，其特征在于：在被浸渍处理后的所述医用织物表面进行喷涂有机硅季铵盐溶液后，在单位面积内，有机硅季铵盐的含量为0.05-0.5g/m2。
  6. 根据权利要求1-3、5任一所述的制备方法，其特征在于：所述有机硅季铵盐为3-(三甲氧基硅烷基)丙基二甲基十八烷基季铵氯化物；和/或
    所述有机硅季铵盐溶液为45mg-85mg/ml。
  7. 根据权利要求1-3、5任一所述的制备方法，其特征在于：所述干燥处理的温度为30-40℃。
  8. 根据权利要求1-3、5任一所述的制备方法，其特征在于：所述医用织物为医用织布或者医用无纺布。
  9. 一种医用抗菌织物，其特征在于：包括医用织物和在所述医用织物上含有的4-(2-氨基乙基)-1,2-苯二酚盐酸盐和有效剂量的有机硅季铵盐，在所述医用织物单位面积内，所述4-(2-氨基乙基)-1,2-苯二酚盐酸盐和有机硅季铵盐的质量比为(1-3)：8。
  10. 根据权利要求9所述的医用抗菌织物，其特征在于：所述有机硅季铵盐为3-(三甲氧基硅烷基)丙基二甲基十八烷基季铵氯化物。
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CN105239380A (zh) * 2015-10-30 2016-01-13 无锡市长安曙光手套厂 一种抗菌防霉纺织品及其制备方法
CN105200663A (zh) * 2015-11-04 2015-12-30 上海洁晟环保科技有限公司 抗菌纳米纤维膜的制备方法

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