WO2018062975A1 - Dispositif de préparation d'une composition cosmétique dans laquelle un épaississant est ajouté à un matériau d'émulsion instantanément émulsionné à l'aide d'un canal microfluidique - Google Patents

Dispositif de préparation d'une composition cosmétique dans laquelle un épaississant est ajouté à un matériau d'émulsion instantanément émulsionné à l'aide d'un canal microfluidique Download PDF

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Publication number
WO2018062975A1
WO2018062975A1 PCT/KR2017/011081 KR2017011081W WO2018062975A1 WO 2018062975 A1 WO2018062975 A1 WO 2018062975A1 KR 2017011081 W KR2017011081 W KR 2017011081W WO 2018062975 A1 WO2018062975 A1 WO 2018062975A1
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WO
WIPO (PCT)
Prior art keywords
fluid
thickener
channel
trauma
emulsifier
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PCT/KR2017/011081
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English (en)
Korean (ko)
Inventor
한경섭
남진
Original Assignee
(주)아모레퍼시픽
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Publication of WO2018062975A1 publication Critical patent/WO2018062975A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4331—Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B01F33/50111—Small portable bottles, flasks, vials, e.g. with means for mixing ingredients or for homogenizing their content, e.g. by hand shaking
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/82—Combinations of dissimilar mixers
    • B01F33/821—Combinations of dissimilar mixers with consecutive receptacles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/87—Application Devices; Containers; Packaging

Definitions

  • the present invention relates to a cosmetic composition manufacturing apparatus for discharging an emulsified material produced by the instant emulsification is made by moving the trauma fluid and the inner fluid fluid along the microfluidic channel, specifically, a fluid moving along the microfluidic channel
  • a cosmetic composition manufacturing apparatus that can improve the feeling of use and control the stability by adding a small amount of thickener to the emulsified materials such as O / W emulsion particles or W / O emulsion particles prepared in a way that is emulsified instantaneously using their special fluid behavior characteristics It is about.
  • the fluid emulsification technique refers to a technique for dispersing a liquid of one of two fluids that do not mix with each other, such as water and oil, into small particles and dispersing the liquid in a stable state in the other liquid.
  • emulsification techniques are widely applied to lotions, creams, essences, massage creams, cleansing creams, makeup bases, foundations, eyeliners, mascaras and the like.
  • O / W (Oil in Water) emulsion particles are prepared by uniformly dispersing a hydrophobic fluid such as oil into a small particle state in a hydrophilic fluid such as water, or in a hydrophilic fluid By uniformly dispersing in a small particle state to prepare a water in oil (W / O) emulsion particles.
  • a hydrophobic fluid such as oil
  • W / O water in oil
  • Such O / W emulsified particles and W / O emulsified particles are called emulsions or emulsified materials.
  • an emulsified material using a hydrophilic fluid and a hydrophobic fluid was prepared by using a physical method.
  • a stirrer is operated to disperse particles of another fluid to one fluid after pouring both hydrophilic and hydrophobic fluids into a large container.
  • a stirrer was used such as a homomixer or a microfluidizer. That is, O / W emulsified particles or W / O emulsified particles were prepared by pouring a hydrophilic fluid and a hydrophobic fluid into a huge container and then mixing the fluids with each other using a stirrer.
  • the interfacial energy between the hydrophilic fluid and the hydrophobic fluid is lowered to easily form emulsions such as O / W emulsified particles or W / O emulsified particles, and maintain the interfacial membrane more firmly.
  • emulsions such as O / W emulsified particles or W / O emulsified particles
  • the emulsion is united, and the hydrophilic fluid and the hydrophobic fluid are separated from each other again. Can be.
  • a surfactant is added to maintain the emulsion state for a long time.
  • thickeners are added into the container to improve the viscosity of the cosmetic.
  • the thickener is added to the container, long-term stability of the product is ensured, and the viscosity of the product may be improved to improve application of the skin.
  • the hydrophilic fluid and the hydrophobic fluid is added to the container and after the emulsification proceeds, the thickener is added and mixed together by the stirrer.
  • the fluidity of the hydrophilic fluid and the hydrophobic fluid is reduced by the thickener, so that the formation of the emulsified material cannot be performed smoothly.
  • the thickener is a factor that affects the movement speed of the hydrophilic fluid and the hydrophobic fluid and the formation of emulsion particles, it is necessary to pay attention to the timing of addition, but conventionally, there was a problem of randomly adding the thickener into the container without such consideration. .
  • An object of the present invention is to add and stir a thickener to an emulsified material after an emulsified material such as O / W emulsified particles or W / O emulsified particles is formed in an instantaneous emulsified manner using the behavior properties of the fluids in the microfluidic channel. It is thereby to provide an apparatus for producing a cosmetic composition capable of improving the feeling of use and stability control of the emulsified material.
  • the housing is installed the pump operable by the user;
  • a fluid receiving portion installed in the housing and configured of a trauma container for receiving a trauma fluid forming an outer trauma of an emulsifying material and an inner trauma container for receiving an inner trauma fluid forming an inner trauma of the emulsifying material;
  • a first channel for joining the trauma fluid and the inner fluid to form the emulsifying material;
  • a second channel connected to the first channel and provided with a space communicating with the first channel so as to form a movement passage of the emulsifying material, and allowing a thickener to be introduced into the emulsifying material;
  • a tube for providing a passage for moving the emulsifier to which the thickener has been passed through the second channel to the pump, thereby providing a cosmetic composition manufacturing apparatus containing the emulsifier to which the thickener has been added.
  • the first channel may further include an emulsifying part that is provided with the trauma fluid and the inner fluid so as to meet each other to form the emulsifying material, and an emulsifying material moving tube installed downstream of the emulsifying function to provide a movement path of the emulsifying material,
  • a cosmetic composition containing an emulsifier added with a thickener characterized in that the second emulsifier passage is formed in communication with the first emulsifier passage formed in the end of the emulsifier moving tube in the vertical direction
  • An apparatus may be provided.
  • a thickener container installed inside the housing; And a thickener injection tube, which is a passage through which the thickener contained in the thickener container is discharged to the outside, wherein the thickener injection tube is in communication with the second channel.
  • Cosmetic composition manufacturing apparatus can be provided.
  • the second channel is provided with a thickener moving tube which is a moving path of the thickener delivered from the thickener injection tube, and downstream of the thickener moving tube is delivered to the second channel through the second emulsifier passage.
  • An apparatus for producing a cosmetic composition containing an emulsifier added with a thickener may be provided, wherein an additional lamination portion is formed for contacting the emulsifier with the thickener moving along the thickener moving tube.
  • a stirring channel having at least one stirring flow section which is a path which allows the thickener and the emulsifying material to mix with each other.
  • An apparatus for producing a cosmetic composition may be provided.
  • the stirring flow unit may further include: a first rotation path guiding the thickener and the emulsifying material to rotate in one direction; A second rotation path for guiding the thickener and the emulsifying material to rotate in different directions; And a redirection path disposed between the first rotation path and the second rotation path to change a rotation direction of the thickener and the emulsifying material.
  • An apparatus may be provided.
  • the cosmetic composition containing the emulsifier to which the thickener is added is discharged to the outside through the tube through the stirring material discharge port communicated with the tube, the thickener formed through the stirring flow portion is stirred.
  • a manufacturing apparatus can be provided.
  • the emulsifying action portion may be provided with a cosmetic composition manufacturing apparatus that is an orifice having a width smaller than the lamination portion where the trauma fluid and the inner wound fluid meet each other.
  • the emulsification action unit emulsifies while moving the trauma fluid and the internal wound fluid in the same direction, emulsifies while moving so as to intersect the trauma fluid and the internal wound fluid, or of the trauma fluid to the lamination part
  • the aspect ratio of the inlet and the inlet of the inner fluid is controlled to emulsify, or the inner fluid, or a mixed fluid of the inner fluid and the outer fluid, passes through a membrane hole to form emulsified particles, or an electric field, a magnetic field, a centrifugal force, a laser.
  • the cosmetic composition manufacturing apparatus may be provided to form emulsified particles using a power source capable of generating any one or more of vibrations, or to form emulsified particles by changing the viscosity, interfacial tension and wettability of a fluid.
  • the second channel may be provided with a cosmetic composition manufacturing apparatus laminated on the upper side or the lower side of the first channel.
  • a cosmetic composition manufacturing apparatus containing an emulsifier added with a thickener may be provided before the trauma fluid and the trauma fluid merge with each other.
  • the outer container and the inner container may be provided with a cosmetic composition manufacturing apparatus which is installed to be separated by a blocking film inside the housing.
  • the pump absorbs fluid by controlling button spring pump, syringe pump, tube pump, gear pump, porous pump, screw pump, pump that absorbs or discharges the fluid by capillary action, electric or vibration or sound wave or piezoelectric material. Or it may be provided with a cosmetic composition manufacturing apparatus which is one of the pump to discharge.
  • O / W emulsified particles or W / O emulsification from the state of being stored as a raw material in the water phase and oil phase at the time required by the user by using the special fluid behavior characteristics of the fluids moving along the microfluidic channel
  • the emulsified material such as particles, can be conveniently prepared in an instant emulsified manner.
  • the emulsified material is produced by the user's pump operation and the external discharge of the made emulsified material is made, there is an advantage in that the emulsified material can be produced and supplied at the time required by the user.
  • FIG. 1 is a perspective view showing an apparatus for preparing a cosmetic composition containing an emulsifier added with a thickener according to an embodiment of the present invention.
  • FIG. 2 is a plan view showing the configuration of a first channel of a fluid channel of the device.
  • FIG 3 is a plan view showing the configuration of a second channel stacked over a first of the fluid channels of the device.
  • FIG. 4 is an enlarged view illustrating a portion A of FIG. 3 and is a plan view illustrating a detailed structure of the stirring channel.
  • FIG. 1 is a perspective view showing an apparatus for preparing a cosmetic composition containing an emulsifier added with a thickener according to an embodiment of the present invention.
  • 2 is a plan view showing a configuration of a first channel of a fluid channel of the device
  • FIG. 3 is a plan view showing a configuration of a second channel stacked on a first channel of the fluid channel of the device.
  • the cosmetic composition manufacturing apparatus 1 which concerns on this invention is formed in the housing 10 by the external shape.
  • One side of the housing 10 may be provided with a pump 70 operable by the user. That is, the user may discharge the materials in the housing 10 to the outside by pressing the pump 70.
  • the pump 70 operable by the user. That is, the user may discharge the materials in the housing 10 to the outside by pressing the pump 70.
  • the pressure of the movement path of the materials in the housing 10 becomes high.
  • the negative pressure is applied to the moving path of the materials and the materials are discharged to the outside.
  • the pump 70 is a means for providing energy for discharging the fluid from the containers 21, 22, and 45 and emulsifying it instantaneously and then discharging it through a discharge hole formed outside the housing 10.
  • the pump 70 is provided at one side of the housing 10. Arranged, the user can operate the operation portion is exposed to the outside of the housing 10, the connection portion for discharging the mixed liquid to the outside may be provided inside the housing 10.
  • the raw material contained in the trauma container 21, the inner wound container 22, and the thickener container 45 is provided to the fluid channel 100 by the pressure generated by the pump 70, and the fluid channel 100 is supplied to the fluid channel 100.
  • the supplied raw materials may be discharged to the pump 70 through the tube 60 after being instantaneously emulsified while moving along a predetermined path.
  • a series of flow paths can be formed from the pump 70 to the respective containers 21, 22, 45 in communication with each other.
  • the pump 70 is described as an example that includes a discharge portion exposed to the outside of the housing 10 to discharge the cosmetic, this is only one example and the spirit of the present invention is not limited thereto.
  • the discharge portion may be provided separately from the pump 70, which may be connected to any point in the series of flow paths connected from the containers 21, 22, 45 to the discharge portion to provide pressure. have.
  • the pump 70 is shown as an example of a push-type pump to apply a negative pressure on the movement path of the fluid in the housing 10 by the user presses and releases the operation unit.
  • the ejection of the raw materials from the containers 21, 22, and 45, the movement in the fluid channel 100, and the ejection of the cosmetic are all realized by the pressure in a single direction formed by the pump 70. Since it can be, there is an advantage that the configuration of the device can be simplified.
  • non-powered pumps include button-spring pumps, syringe pumps, flexible tube pumps, gear pumps, porous pumps, thread inserting pumps, and the like.
  • a pump for absorbing or discharging fluid by capillary action may be applied by applying an orifice, a rollerball, a pencil, or the like to the discharge port.
  • a pump for controlling the electrical, vibration, sound waves, piezoelectric material (piezoelectric material) to absorb or discharge the fluid may be applied as the power pump.
  • the inside of the housing 10 is provided with a trauma container 21 in which the trauma fluid is accommodated, and an inner trauma container 22 in which the trauma fluid is accommodated.
  • the trauma container 21 and the inner container 22 may be provided inside the housing 10 to form one fluid container 20.
  • a blocking film 23 extending in the vertical direction and separating the inner space of the fluid receiving part 20 is installed at the center of the fluid receiving part 20. The trauma fluid is accommodated on one side of the barrier film 23 to form the trauma container 21, and the trauma fluid is received on the other side to form the inner container 22.
  • the housing 10 is provided with a thickener container 45 which is configured separately from the fluid receiving portion 20.
  • the thickener may be stored in the thickener container 45.
  • the neutralizing agent may be added to the trauma fluid accommodated in the trauma container 21. That is, the neutralizing agent is added to the trauma fluid in a state where the internal fluid and the emulsion particles are formed, and then sequentially contacted and stirred with the thickener to produce an emulsified material which is gradually neutralized and increased.
  • the trauma container 21 and the trauma container 22 are connected to the trauma fluid injection tube 30 and the trauma fluid injection tube 40 which are the paths of trauma fluid and the trauma fluid stored therein, respectively. That is, the trauma fluid accommodated in the trauma container 21 may be discharged out of the trauma container 21 along the trauma fluid injection tube 30. Similarly, the inner wound fluid contained in the inner wound container 22 may be discharged out of the inner wound container 22 along the inner wound fluid inlet tube 40.
  • the thickener container 45 is connected to a thickener injection tube 46 which is a moving path of the thickener stored therein. That is, the thickener contained in the thickener container 45 may be discharged out of the thickener container 45 along the thickener injection tube 46.
  • the microfluidic channel 100 using a single negative pressure was applied instead of using a conventional syringe pump using a positive pressure as a cosmetic composition manufacturing apparatus. That is, the present invention has the advantage that the apparatus according to the present invention can be directly applied to the general cosmetic container and pump structure by using a method in which a single negative pressure is applied to the microfluidic channel 100 as a discharge method of the emulsified material.
  • the interfacial fluid and the interphase fluid have high interfacial tension and do not easily mix with each other, it has been quite difficult to form and maintain emulsion particles without using an excessive amount of surfactant (1% to 5%).
  • the surfactant or the like is used. There is an advantage that the emulsification can be achieved quickly by not using or adding a minimum amount.
  • the principle that any one of the two fluids that do not easily mix with each other to break the flow of the other fluid to form the emulsion particles also helps to reduce the surfactant.
  • the emulsification method using the microfluidic channel 100 has many advantages as described above, but there is a limit in the production speed compared to the existing emulsification apparatus using a large tank and an agitator, so it is difficult to apply to the cosmetic manufacturing apparatus.
  • the present invention has developed a microfluidic channel 100 applicable to the container and adopted the instant emulsification method that can be emulsified based on the one-time discharge amount at the time desired by the user.
  • the fluid channel 100 may be formed on the bottom surface of the housing 10, for example, in the form of a moving passage for moving the fluid.
  • the installation position and shape of the fluid channel 100 is not limited thereto.
  • the opening and closing control such as a valve so that the contents can be discharged to the flow path (30, 40, 46) only when pressure is applied to the connection portion of each container (21, 22, 45) and the flow path (30, 40, 46) Means may be provided.
  • the fluid channel 100 includes a first channel 50 constituting a lower portion and a second channel 80 stacked on an upper portion of the first channel 50.
  • the first channel 50 is stacked on the second channel 80 as an example, but the spirit of the present invention is not limited thereto.
  • the first channel 50 may be stacked below the second channel 80 or provided on the same plane.
  • the second channel 80 is stacked below the first channel 80, the entire flow path can be configured relatively short, so that the configuration of the device can be simplified.
  • the first emulsifier passage 59 and the second emulsifier passage 81 may be the same.
  • injection holes communicating with the trauma fluid injection tube 30 and the internal injury fluid injection tube 40 may be formed in the first channel 50. That is, the first channel 50 is an inflow passage of the trauma fluid inlet 51, which is an inflow passage of the trauma fluid moved along the trauma fluid injection tube 30, and an inflow passage of the inner fluid, which is moved along the inner trauma fluid injection tube 40.
  • An internal wound fluid inlet 54 is included.
  • the trauma fluid introduced into the first channel 50 through the trauma fluid inlet 51 may be divided into a first branch pipe 52 and a second branch pipe 53, and moved to a downstream side toward the pump 70.
  • downstream means a direction in which the fluid stored in the fluid receiving portion 20 is discharged to the outside through the pump 70 through the tube 60 by the user's pump operation.
  • the inner phase fluid introduced into the first channel 50 through the inner wound fluid inlet 54 may be moved downstream along the inner wound fluid moving tube 55.
  • the trauma fluid moved along the first branch pipe 52 and the second branch pipe 53 and the inner wound fluid moved along the inner wound fluid moving tube 55 meet each other at the lamination part 56. That is, the lamination portion 56 means a point where the trauma fluid and the inner fluid meet first in the housing 10.
  • the trauma fluid and the internal fluid which are met at the lamination part 56 pass through the emulsification part 58 and become an emulsion, that is, an emulsion material.
  • an emulsion material that is, an emulsion material.
  • the orifice 58 having a relatively narrower width than the lamination portion 56 is provided as the emulsifying action portion (58).
  • the trauma fluid and the inner fluid which are met at the lamination part 56 pass through the orifice 58 and the direction of force of the trauma fluid in the narrowing direction (vertical direction) inside the orifice 58 and the flow direction of the fluid (horizontal direction) (orifice ( 58) the shear force is applied to the inner phase fluid in a diagonal direction gathered toward the center side to interrupt the flow of the inner phase fluid and form an emulsifying material.
  • capillary instability increases when two non-mixing fluids pass through the orifice 58 with the interface unstable, and the channel with the orifice 58 does not have a small energy compared to the channel without the channel.
  • the flow can be interrupted and the broken internal fluid is formed into a sphere to maintain a stable state.
  • the emulsification unit 58 is to allow the trauma fluid to stop the flow of the mixed fluid so that the mixed fluid is dispersed in the trauma fluid in the form of particles.
  • the orifice is provided as the emulsification unit 58.
  • the spirit of the present invention is not limited thereto.
  • the emulsification method using the orifice as in the present embodiment may be referred to as flow-focusing emulsification, which allows the fluids of different phases to flow in the same direction, but by placing the orifices at the confluence of the trauma fluid This allows the flow to break (Flow-Focusing).
  • the flow of the trauma fluid changes in the diagonal direction inside the orifice and can transmit a stronger shear force to the mixed fluid, thereby forming emulsified particles more easily and forming emulsified particles of a certain size.
  • various embodiments may be applied to the emulsifying unit 58.
  • a method of emulsifying while moving fluids of different phases in the same direction (Co-Flow method), so that fluids of different phases may intersect.
  • Method of emulsifying while moving (Cross-Flow method)
  • Method of forming emulsified particles in the lamination part (Step Emulsification method)
  • Step Emulsification method by controlling the aspect ratio of the inlet of the trauma fluid to the lamination part and the inlet of the inner phase fluid to be large or low.
  • a method of forming emulsion particles by passing a mixed fluid of two phases through a hole of a membrane may be used (Membrane Emulsification method).
  • the emulsifying unit 58 may use a power source, for example, an electric field, a magnetic control, a centrifugal control, an optical control, a vibration control, a piezoelectric material.
  • a power source for example, an electric field, a magnetic control, a centrifugal control, an optical control, a vibration control, a piezoelectric material.
  • a channel in which emulsion particles are formed using Piezoelectric control or the like may be used.
  • the emulsifying unit 58 may form emulsified particles by changing the viscosity, interfacial tension and wettability of the fluid, for example, electrorheological (ER) or magnetorheological (MR) fluids, photo-sensitive Fluids may be applied.
  • ER electrorheological
  • MR magnetorheological
  • the emulsified material formed through the orifice 58 moves along the emulsified material moving tube 57.
  • upstream refers to the direction opposite to the "downstream”, the direction opposite to the direction of movement of the fluid by the user's pump operation, that is, the pump 70, the tube 60, the fluid channel 100 and the fluid Means the direction toward the receiving portion 20.
  • the size and content of the emulsified particles is an important factor in determining the quality of the cosmetics.
  • the injection ratio of the trauma fluid to the internal fluid is generally equal or higher.
  • the injection amount of the trauma fluid may be 1 to 30 times the injection amount of the internal fluid.
  • the inflow velocity of the fluid is determined by the structural elements of the fluid channel 100 and the flow conditions of the fluid, and thus the size and content of the emulsified particles. Will be different.
  • Structural elements of the fluid channel 100 may be, for example, the height ratio of the channel, the width of the orifice, and the width ratio of the injection channel of each fluid.
  • the flow conditions of the fluid may include, for example, the strength of the negative pressure, the flow rate ratio of the two fluids, and the viscosity ratio of the two fluids.
  • Emulsion particles have a smaller channel height, a narrow orifice width, a higher negative pressure intensity, a larger flow rate ratio of the trauma fluid to the internal fluid, and a higher viscosity of the internal fluid than the trauma fluid.
  • the size of the emulsion particles is increased, and on the contrary, the size of the emulsified particles is increased.
  • a method for adjusting the flow rate ratio between the inner-phase fluid and the trauma fluid a method of adjusting the inner diameter of each injection port of the inner-phase fluid and the trauma fluid is used. Specifically, when the inner diameter of the trauma fluid inlet is made twice as large as the inner diameter of the inner wound fluid inlet, the flow rate of the trauma fluid under the single negative pressure is increased by two times compared to the inner wound fluid. In this way, the flow rate ratio between the inner fluid and the outer fluid can be adjusted.
  • the flow rate ratio of the two fluids should be made to be the same as much as possible.
  • the trauma fluid lacks a force to cut off the flow of the inner fluid, thereby making it difficult to form emulsion particles.
  • the width ratio of the trauma fluid channel and the inner fluid fluid channel by adjusting the width ratio of the trauma fluid channel and the inner fluid fluid channel, the content of the emulsified particles due to the speed control at the portion where the two fluids meet (the lamination part) even without adjusting the injection flow rate ratio of the two fluids.
  • the width of the trauma fluid channel is reduced to half the width of the trauma fluid channel, even if the trauma fluid is injected twice as fast, the trauma fluid is twice as fast at the joint where the two fluids meet, Not only emulsified particles are formed in the same effect as when the inner phase fluid is injected at the same flow rate ratio, but also because the inner fluid is doubled, the content can also be doubled.
  • a first emulsion material passage 59 is formed at an end portion of the emulsifier moving tube 57 to communicate with the second channel 80 to serve as a passage through which the emulsion material exits from the first channel 50.
  • a second emulsifier passage 81 is formed in the second channel 80 to communicate with the first emulsifier passage 59 and serve as a passage for receiving an emulsifier into the second channel 80.
  • the emulsified material introduced into the second channel 80 through the second emulsified material passage 81 is moved to the additional lamination portion 84 along the emulsified material pipe 81a.
  • the second channel 80 is provided with a thickener moving tube 83 which is a moving path of the thickener delivered from the thickener injection tube 46.
  • the thickener stored in the thickener container 45 in the housing 10 is moved by the negative pressure to the thickener inlet 82 of the second channel 80 along the thickener inlet tube 46. Therefore, the thickener introduced into the second channel 80 through the thickener inlet 82 is delivered to the additional lamination portion 84 along the thickener moving tube 83.
  • the emulsion material delivered to the second channel 80 through the second emulsifying material passage 81 is brought into contact with the thickener moving along the thickener moving tube 83. Since the lamination portion 84 is formed, the additional lamination portion 84 makes contact with the thickener with the emulsifying material.
  • the emulsifier in contact with the thickener is moved to the stirring channel 86, whereby the mixing of the thickener and the emulsifier is performed. Specifically, the emulsified material in contact with the thickener is moved to the stirring channel 86 which is bent a plurality of times through the stirring inlet channel 85, and the increased emulsified material which is stirred through the stirring channel 86 is It moves along the stirred outflow channel 87 and is discharged to the tube 60.
  • Centrifugal force can be generated in the flow of the fluid passing through the stirring channel 86 by providing a flow path in which the stirring channel 86 is bent (curved), and at the same time a vortex can be formed in the flow of the fluid. have. And centrifugal forces and the generation of vortices can activate the mixing of thickeners and emulsifiers.
  • the stirring channel 86 is bent in a staggered direction, the moving directions of the fluids can be reversed, and the collision between the redirected fluids can further activate the mixing of the thickener and the emulsifier.
  • the stirring channel 86 has a curved shape, the installation area of the second channel 80 having a relatively long flow path can be reduced while providing a sufficient mixing path.
  • the shape of the stirring channel 86 according to the present embodiment is not limited to bent in a staggered direction, but may be bent in the same direction or a combination of the two forms, or may have various forms that may form other vortices. have.
  • the stirring method according to the present embodiment is not limited to the form using only a vortex, but the method of increasing the surface area by stacking two fluids, applying an electric field, using a sound wave, and stirring in other microfluidic channels. It can have various forms.
  • the process of mixing the thickener and the emulsifying material by moving the emulsified material in contact with the thickener along the stirring channel 86 will be described.
  • FIG. 4 is an enlarged view illustrating a portion A of FIG. 3 and is a plan view illustrating a detailed structure of the stirring channel.
  • the stirring channel 86 is provided with one or more stirring flow portions that provide rotational paths in different directions to mix the thickener and the emulsifying material.
  • four stirring flow portions are illustrated as being installed, but the number of the stirring flow portions is not limited thereto.
  • Stirred flow portion may be configured in a structure corresponding to each other. Accordingly, in the present specification, the stirring flow portion 86a of one of the four stirring flow portions will be described as an example.
  • the stirring flow portion 86a includes a first rotation path 861 for guiding the thickener and the emulsifier to rotate in one direction, and a second rotation path 862 for guiding the thickener and the emulsifier to rotate in the other direction. It consists of.
  • a direction change path 863 is provided between the first rotation path 861 and the second rotation path 862 to change the rotation direction of the thickener and the emulsifier. That is, the first rotation path 861 guides the incoming fluid to rotate in one direction, and the second rotation path 862 guides the fluid rotated in one direction to rotate in the other direction and redirects the path 863. ) Switches the direction of rotation of the fluid between the first rotation path 861 and the second rotation path 862.
  • the emulsion material contacted with the thickener by passing through the additional lamination portion 84 is rotated counterclockwise while passing through the first rotation path 861 to achieve the first stirring.
  • the increased emulsified material in which the primary agitation is made passes through the redirection path 863 and then rotates in a clockwise direction through the second rotation path 862 to perform the secondary agitation. That is, the thickener is in contact with the emulsifier is rotated in different directions while passing through the first rotation path 861 and the second rotation path 862, the stirring of the thickener and the emulsifier is actively made.
  • Incremental emulsified material passing through the stirring channel 86 in the above manner is moved to the tube 60 through the emulsified material discharge 88 past the stirring outflow channel 87.
  • the tube 60 is made of a transparent material so that the user can check the emulsified material moved through the tube 60 from the outside.
  • the part surrounding the tube 60 of the housing 10 should also be made of a material that can be visually confirmed from the outside so that the emulsified material moved through the tube 60 can be confirmed from the outside.
  • a pump 70 is installed at the end of the tube 60, and the user may take out the emulsified substance that has passed through the cosmetic composition manufacturing apparatus 1 through the outlet of the pump 70.
  • the trauma fluid may be a hydrophilic fluid such as water and the internal fluid may be a hydrophobic fluid such as oil. Hydrophilic fluid is then stored in the trauma container 21 and hydrophobic fluid is stored in the inner container 22.
  • the hydrophilic fluid moves to the trauma fluid inlet 51 of the first channel 50 along the trauma fluid inlet tube 30, and the hydrophobic fluid moves along the inner channel fluid inlet tube 40 to the first channel 50. It moves to the inner phase fluid inlet (54).
  • the hydrophilic fluid moved to the first channel 50 moves to the lamination section 56 along the first branch pipe 52 and the second branch pipe 53, and the hydrophobic fluid moves along the inner phase fluid moving pipe 55. It moves to the lamination part 56. That is, the hydrophilic fluid and the hydrophobic fluid meet each other at the lamination portion 56 of the first channel 50.
  • the internal fluid and the external fluid flow through the orifice 58, and an emulsification phenomenon occurs, and the emulsified material passed through the orifice 58 moves along the emulsion moving tube 57. That is, the emulsified material in a form in which the hydrophilic fluid surrounds the hydrophobic fluid is made.
  • the emulsified material formed by this process is called O / W (Oil in Water) emulsified particles because the oil is dispersed in water.
  • the emulsified material moving tube 57 is preferably made of a hydrophilic material or the inner wall coating of the tube.
  • the emulsifying material has a configuration in which the outside is made of a hydrophilic fluid and the hydrophobic fluid is dispersed therein, when the emulsifying material moving tube 57 is made of a hydrophilic material, the hydrophilic fluid part of the emulsifying material is formed into an emulsifying material moving tube ( It is attracted to the wall of 57). Therefore, the O / W emulsion particles as described above can be smoothly moved along the emulsion material moving tube 57 while maintaining the shape and structure.
  • the water contact angle (WCA) may be set to 0 degrees to 50 degrees when the emulsion moving tube 57 has hydrophilicity. In this case, the O / W emulsion particles may flow more smoothly.
  • the O / W emulsion particles passing through the first emulsifier material passage 59 of the first channel 50 are moved to the second channel 80 stacked on the first channel 50.
  • the O / W emulsified particles are formed along the second emulsifier passage 81 of the second channel 80 in communication with the first emulsifier passage 59 of the first channel 50. Is moved to.
  • O / W emulsified particles introduced into the second channel 80 through the second emulsifier passage 81 are moved to the additional lamination portion 84 along the emulsifier tube 81a.
  • the thickener which is moved from the thickener container 45 to the thickener injection hole 82 formed in the second channel 80 through the thickener injection pipe 46, is formed of a thickener moving tube of the second channel 80 ( It is moved to the additional lamination portion 84 along 83). Therefore, the O / W emulsion particles and the thickener come into contact with each other at the additional lamination part 84.
  • the O / W emulsified particles in contact with the thickener is moved to the stirring channel 86, the stirring of the thickener and O / W emulsified particles is made, the O / W emulsified particles are completed Agitated material outlet 88 is moved.
  • the O / W emulsified particles in which the thickener moved along the stirring material outlet 88 is stirred may be passed to the user through the inlet of the pump 70 through the tube 60.
  • the trauma fluid may be a hydrophobic fluid such as an oil and the internal fluid may be a hydrophilic fluid such as water. Hydrophobic fluid is then stored in the trauma container 21 and hydrophilic fluid is stored in the inner container 22.
  • the hydrophobic fluid is moved along the trauma fluid inlet tube 30 to the trauma fluid inlet 51 of the first channel 50, and the hydrophilic fluid is along the inner channel fluid inlet tube 40. It moves to the inner phase fluid inlet (54).
  • the hydrophobic fluid and the hydrophilic fluid moved to the first channel 50 meet each other at the lamination portion 56 of the first channel 50.
  • the internal fluid and the external fluid are emulsified while passing through the orifice 58, the emulsified material passed through the orifice 58 is moved along the emulsified material moving tube 57.
  • an emulsifying material is formed in which the hydrophobic fluid surrounds the hydrophilic fluid.
  • the emulsified material formed by this process is called W / O (Water in Oil) emulsified particles because water is dispersed in oil.
  • the emulsified material moving tube 57 is preferably made of a hydrophobic material or the inner wall coating of the tube.
  • the emulsifying material has a configuration in which the outside is made of a hydrophobic fluid and the hydrophilic fluid is dispersed therein, when the emulsifying material moving tube 57 is made of a hydrophobic material, the hydrophobic fluid portion of the emulsifying material is formed into an emulsifying material moving tube ( It is attracted to the wall of 57). Therefore, the above W / O emulsified particles can be smoothly moved along the emulsified material moving tube 57 while maintaining its shape and structure.
  • the contact angle WCA with water may be set to 70 degrees to 120 degrees. In this case, the W / O emulsified particles may flow more smoothly.
  • the W / O emulsified particles passing through the first emulsifier material passage 59 of the first channel 50 are moved to the second channel 80 stacked on the first channel 50. Specifically, the W / O emulsified particles are formed along the second emulsifier passage 81 of the second channel 80 in communication with the first emulsifier passage 59 of the first channel 50. Is moved to.
  • the W / O emulsified particles introduced into the second channel 80 are moved to the additional lamination portion 84 along the emulsion material pipe 81a.
  • the thickener which is moved from the thickener container 45 to the thickener injection hole 82 formed in the second channel 80 through the thickener injection pipe 46, is formed of a thickener moving tube of the second channel 80 ( It is moved to the additional lamination portion 84 along 83). Accordingly, the W / O emulsified particles and the thickener come into contact with each other at the additional lamination portion 84.
  • the W / O emulsified particles in contact with the thickener is moved to the stirring channel 86 to the stirring of the thickener and the W / O emulsified particles, the W / O emulsified particles are completed stirring with the thickener Agitated material outlet 88 is moved.
  • the W / O emulsified particles in which the thickener moved along the stirring material outlet 88 is stirred may be passed to the user through the inlet of the pump 70 through the tube 60.
  • the emulsified material can be increased without disturbing the formation of the emulsified particles before or at the same time as the emulsified particles are formed, thereby increasing There is an advantage that can increase the feeling of use and stability.
  • the emulsified material (emulsion) is produced by the user's pump operation, and the external discharge of the made emulsified material is made, it is possible to produce and supply the emulsified material at the time required by the user. There is an advantage.
  • the present invention relates to an apparatus for producing a cosmetic composition in which a thickener is added to an emulsified material emulsified instantaneously using a microfluidic channel, and can be used in the cosmetic industry.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
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  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Colloid Chemistry (AREA)
  • Cosmetics (AREA)

Abstract

Un aspect de la présente invention peut fournir un dispositif de préparation d'une composition cosmétique contenant un matériau d'émulsion auquel est ajouté un épaississant, le dispositif comprenant : un boîtier sur lequel une pompe actionnable par un utilisateur est installée; une partie de réception de fluide qui comprend un récipient de phase externe, installé dans le boîtier, pour recevoir un fluide de phase externe formant une phase externe d'un matériau d'émulsion, et un contenant de phase interne, installé dans le boîtier, pour recevoir un fluide de phase interne formant une phase interne du matériau d'émulsion; un premier canal permettant au fluide de phase externe et au fluide de phase interne de se rejoindre et de former ainsi le matériau d'émulsion; un second canal relié au premier canal, pourvu d'un espace communiquant avec le premier canal de façon à former un trajet de déplacement pour le matériau d'émulsion, et permettre à un épaississant d'être ajouté au matériau d'émulsion; et un tube fournissant un trajet tel que le matériau d'émulsion, ayant l'épaississant ajouté à celui-ci et ayant traversé le second canal, se déplace vers la pompe.
PCT/KR2017/011081 2016-09-30 2017-09-29 Dispositif de préparation d'une composition cosmétique dans laquelle un épaississant est ajouté à un matériau d'émulsion instantanément émulsionné à l'aide d'un canal microfluidique WO2018062975A1 (fr)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020109087A (ja) * 2018-12-31 2020-07-16 アモーレパシフィック コーポレーションＡｍｏｒｅｐａｃｉｆｉｃ Ｃｏｒｐｏｒａｔｉｏｎ 化粧品製造装置
CN111482096A (zh) * 2018-12-31 2020-08-04 株式会社爱茉莉太平洋 瞬间乳化化妆品制备装置
US11440045B2 (en) 2019-01-03 2022-09-13 The Procter & Gamble Company Method of providing a personalized skin care composition where the composition is mixed with a mixing element that does not contact the ingredients during mixing

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102197492B1 (ko) * 2018-10-31 2020-12-31 (주)아모레퍼시픽 순간 유화 화장품 제조 장치

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000189244A (ja) * 1998-12-01 2000-07-11 L'oreal Sa 多相組成物を分配するための装置、この種の装置の使用および使用方法
KR20100086779A (ko) * 2009-01-23 2010-08-02 경원대학교 산학협력단 나노필터 구조체를 포함하는 화장품 용기
KR20140005450U (ko) * 2013-04-11 2014-10-22 (주)아모레퍼시픽 이액형 용액을 혼합을 위한 화장용기
KR20150116485A (ko) * 2014-04-07 2015-10-16 한국과학기술원 복수개의 내부 액적을 구비하는 이중액적의 제조 방법 및 이에 의한 이중액적
KR20150120016A (ko) * 2014-04-16 2015-10-27 한국과학기술원 복수개의 내부 액적을 구비하는 이중액적을 제조하는 장치 및 이에 의한 이중액적

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2718018B1 (fr) * 1994-04-05 1996-04-26 Oreal Composition cosmétique et/ou dermatologique à support hydrophile et vitamine C mélangeables extemporanément.
KR100222000B1 (ko) 1997-04-28 1999-09-15 윤동한 다중 액정 리포좀 유화에 의한 화장료 조성물과 그 제조방법
TW447327U (en) * 1999-02-05 2001-07-21 Wang Jiang Ming Emulsifying and stirring device for water liquid treatment within tubular space
JP2002128634A (ja) * 2000-10-24 2002-05-09 Nippon Bee Kk 乳化化粧料の製造方法
CN2865838Y (zh) * 2006-01-26 2007-02-07 金柏林 喷雾混合乳化器
JP2009092192A (ja) * 2007-10-11 2009-04-30 Surpass Kogyo Kk 背圧対応型バルブ
GB201002666D0 (en) * 2010-02-17 2010-04-07 Pursuit Dynamics Plc Apparatus and method for entraining fluids
US8857741B2 (en) * 2012-04-27 2014-10-14 Conopco, Inc. Topical spray composition and system for delivering the same

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000189244A (ja) * 1998-12-01 2000-07-11 L'oreal Sa 多相組成物を分配するための装置、この種の装置の使用および使用方法
KR20100086779A (ko) * 2009-01-23 2010-08-02 경원대학교 산학협력단 나노필터 구조체를 포함하는 화장품 용기
KR20140005450U (ko) * 2013-04-11 2014-10-22 (주)아모레퍼시픽 이액형 용액을 혼합을 위한 화장용기
KR20150116485A (ko) * 2014-04-07 2015-10-16 한국과학기술원 복수개의 내부 액적을 구비하는 이중액적의 제조 방법 및 이에 의한 이중액적
KR20150120016A (ko) * 2014-04-16 2015-10-27 한국과학기술원 복수개의 내부 액적을 구비하는 이중액적을 제조하는 장치 및 이에 의한 이중액적

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020109087A (ja) * 2018-12-31 2020-07-16 アモーレパシフィック コーポレーションＡｍｏｒｅｐａｃｉｆｉｃ Ｃｏｒｐｏｒａｔｉｏｎ 化粧品製造装置
CN111482096A (zh) * 2018-12-31 2020-08-04 株式会社爱茉莉太平洋 瞬间乳化化妆品制备装置
CN111495223A (zh) * 2018-12-31 2020-08-07 株式会社爱茉莉太平洋 化妆品制备装置
CN111495223B (zh) * 2018-12-31 2023-12-29 株式会社爱茉莉太平洋 化妆品制备装置
CN111482096B (zh) * 2018-12-31 2024-03-19 株式会社爱茉莉太平洋 瞬间乳化化妆品制备装置
US11440045B2 (en) 2019-01-03 2022-09-13 The Procter & Gamble Company Method of providing a personalized skin care composition where the composition is mixed with a mixing element that does not contact the ingredients during mixing

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