WO2018058292A1 - Procédé de positionnement d'un applicateur basé sur une imagerie par résonance magnétique, et applicateur - Google Patents

Procédé de positionnement d'un applicateur basé sur une imagerie par résonance magnétique, et applicateur Download PDF

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Publication number
WO2018058292A1
WO2018058292A1 PCT/CN2016/100309 CN2016100309W WO2018058292A1 WO 2018058292 A1 WO2018058292 A1 WO 2018058292A1 CN 2016100309 W CN2016100309 W CN 2016100309W WO 2018058292 A1 WO2018058292 A1 WO 2018058292A1
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WIPO (PCT)
Prior art keywords
applicator
tube
positioning
magnetic resonance
outer tube
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PCT/CN2016/100309
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English (en)
Chinese (zh)
Inventor
朱艳春
谢耀钦
熊璟
付楠
陈昳丽
王磊
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深圳先进技术研究院
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Priority to PCT/CN2016/100309 priority Critical patent/WO2018058292A1/fr
Publication of WO2018058292A1 publication Critical patent/WO2018058292A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

Definitions

  • the present application relates to the field of applicator positioning technologies, and in particular, to a method and a source device for applying a position based on magnetic resonance imaging.
  • the positioning of the applicator is usually obtained by a positive lateral radiograph or a three-dimensional computed tomography (CT) scan.
  • CT computed tomography
  • MRI Magnetic Resonance Imaging
  • Post-loading radiation therapy refers to placing a treatment container (applicator) without a radioactive source on the treatment site, and the computer remote-controlled stepper motor (post-installation machine) sends the radioactive source to the applicator for radiation therapy, so as to avoid prevention. Medical staff were injured by radiation during the treatment.
  • the function of the post-installation machine is to place the radioactive source accurately, safely and regularly into the human lesion through the application tube.
  • Post-loading therapy is an auxiliary treatment for external irradiation.
  • the dose at the near-source is much larger than the distance from the far source.
  • tumor tissue can achieve an effective killing dose, while adjacent normal tissues can be protected. It can be seen that one of the quality assurances of the post-loading treatment is the accuracy of the radioactive source, which directly affects the therapeutic effect.
  • the workflow of the post-loading treatment is to insert the disinfected application tube into the patient's treatment site according to the doctor's diagnosis result, and fix it; then, the positive side X-ray is taken by the simulator.
  • Tablet or 3D CT image locate the position of the application tube, formulate the optimal treatment time at each point, design the treatment plan; connect the application tube with the post-loading treatment machine, and then perform the radiotherapy plan through the operation of the installed machine control system; After a certain amount of irradiation is completed, under the control of the post-installation computer, the radioactive source automatically returns to the reservoir and completes a close-in post-loading treatment.
  • magnetic resonance imaging has the advantages of no radiation, high resolution, high soft tissue contrast, etc., which makes magnetic resonance imaging more and more attention.
  • the positive side X-ray film is taken by the simulator, and the treatment plan is made according to the coordinate reconstruction result.
  • the treatment plan is simple, the dose accuracy is very low, and the lesion range and the normal tissue cannot be correctly evaluated. The situation in turn gives a personalized and precise radiotherapy dosage regimen.
  • Chinese patent CN101152090A has published a "single-tube post-loading device for cervical cancer that can be used for CT scanning", which can scan and image the cervical cancer posterior device, which includes a hollow source pipe.
  • One end of the pipeline is connected with the rear application tube, and the other end is a lesion treatment end.
  • the treatment end is composed of an elliptical inner tube made of a shielding functional material, and a circular hole is arranged in the center of the inner tube, and the circular hole is
  • the application pipeline is connected, and the movable sleeve is also provided with a cylindrical outer tube made of CT-compatible polymer material.
  • the invention can obtain a three-dimensional image of the lesion by CT scanning, thereby accurately estimating the lesion.
  • the scope and surrounding normal tissue conditions provide an image data basis for individualized and accurate radiotherapy.
  • CT three-dimensional imaging can realize the positioning of the applicator and develop a precise radiotherapy plan, but the CT image soft tissue contrast is poor, and usually the internal irradiation therapy is for the soft tissue cavity, and the CT image is not well presented.
  • the three-dimensional magnetic resonance image can clearly show the structure of the lesion and surrounding organs, but the current application of the polymer tube for magnetic resonance imaging is often not because of magnetic resonance imaging.
  • the signal is reflected in black on the three-dimensional image, which results in the magnetic resonance three-dimensional image not being able to exert its original advantages to accurately locate the position of the application tube, and also affects the observability of the surrounding tissue lesions.
  • an object of the present application is to provide a magnetic resonance imaging-based application position localization method and an applicator for accurately positioning a position of a source pipe in a magnetic resonance image, and Clearly show the shape and pathological changes of the tissues and organs around the pipe of the applicator, and effectively improve the treatment accuracy.
  • the magnetic resonance imaging-based application position localization method proposed by the embodiment of the present application includes: inserting a positioning tube into the outer tube of the applicator; inserting the outer tube of the applicator inserted with the positioning tube into the application source
  • the target site is subjected to three-dimensional magnetic resonance imaging; the application position is determined according to the imaging agent and the positioning device in the positioning tube.
  • a magnetic resonance imaging-based applicator includes a post-installation machine, a radioactive source channel, and an applicator outer tube, and the applicator further includes matching the outer tube of the applicator.
  • Positioning tube, wherein the positioning tube is hollow, internally filled with a developer for magnetic resonance imaging and a positioning device for being built into the outer tube of the applicator during magnetic resonance imaging Insert the application target site with the outer tube of the applicator.
  • the applicator tube can be highlighted in the three-dimensional magnetic resonance imaging, which can be accurately Positioning the position of the applicator tube and the relative angle and relative depth of the application site and the application tube clearly show the morphological structure and pathological changes of the diseased tissue and surrounding tissues and organs, providing better soft tissue contrast and better showing the lesion
  • the tissue characteristics allow precise positioning of the applicator tubing and provide a basis for precise design of the radiotherapy plan, accurate control of where the radioactive source resides and time, and improved treatment accuracy and safety.
  • FIG. 1 is a schematic flow chart of a method for locating a position based on magnetic resonance imaging according to an embodiment of the present application
  • FIG. 2 is a schematic structural view of a magnetic resonance imaging based applicator according to an embodiment of the present application
  • FIG. 3 is a schematic diagram of a positioning tube of a magnetic resonance imaging based applicator according to an embodiment of the present application
  • FIG. 4 is a schematic cross-sectional view of a positioning tube of a magnetic resonance imaging-based applicator according to an embodiment of the present application
  • FIG. 5 is a schematic diagram of a magnetic resonance imaging based applicator of another embodiment of the present application.
  • Figure 6 is a longitudinal sectional view of the inner tube of the applicator according to another embodiment of the present application.
  • Figure 7 is a cross-sectional view showing the inner tube of the applicator of another embodiment of the present application.
  • FIG. 8 is a schematic flow chart of a method for locating a position based on magnetic resonance imaging according to another embodiment of the present application.
  • FIG. 9 is a schematic diagram of a model for depth position calculation of a magnetic resonance imaging based application position according to another embodiment of the present application.
  • Embodiments of the present application provide a method and device for applying a position based on magnetic resonance imaging.
  • FIG. 1 is a schematic flow chart of a method for locating a position based on magnetic resonance imaging according to an embodiment of the present application. As shown in FIG. 1, the method includes:
  • step 101 the positioning tube is inserted into the applicator tube.
  • the positioning tube is matched with the applicator tube, and the differently sized applicator tubes are provided with corresponding positioning tubes, which can be highlighted in three-dimensional magnetic resonance imaging.
  • Step 102 inserting the outer tube of the applicator inserted with the positioning tube into the application target site, and performing three-dimensional magnetic resonance imaging.
  • Step 103 Determine a source location according to the imaging agent and the positioning device in the positioning tube.
  • the applicator tube of the present invention is made of MRI compatible polymer material, and the positioning tube is also made of a material suitable for magnetic resonance imaging.
  • the positioning tube is sized to match the outer tube of the applicator, the positioning tube being a hollow tube filled with the imaging agent and positioning device having a high signal to noise ratio under magnetic resonance.
  • the imaging agent may be oil, water or other contrast enhancing agent (or imaging agent, contrast agent, etc.) suitable for magnetic resonance imaging, pre-closed in the positioning tube to ensure high in the three-dimensional magnetic resonance image Lights up the position of the application tube.
  • the contrast enhancer is, for example, a complex of DTPA ( ⁇ -diethylenediaminepentaacetic acid) or the like.
  • the positioning device may comprise an angular positioning device and a depth positioning device for determining the angle and depth of a certain target position in the magnetic resonance imaging with respect to the outer tube of the applicator.
  • the three-dimensional magnetic resonance localization treatment has a lower radiation and provides better soft tissue contrast than existing CT-guided internal illumination treatments. Since the internal irradiation treatment is mainly for treating the cavity lesions in the human body, it is better to present the diseased tissue and the peripheral organs, which is the basic condition for formulating an accurate radiotherapy treatment plan.
  • the outer tube of the applicator is inserted into the patient body in advance, and the positioning tube for the magnetic resonance imaging positioning and the outer tube of the applicator is inserted into the outer tube. Since the positioning tube is designed with a positioning device, The positioning tube is filled with a magnetic resonance imaging agent to ensure accurate display of the position of the outer tube of the applicator in the 3D magnetic resonance image.
  • the three-dimensional magnetic resonance scan is completed, and a treatment plan for radiation therapy is prepared according to the condition of the diseased tissue and the normal tissue or organ in the three-dimensional magnetic resonance image and the position of the outer tube of the applicator.
  • the positioning tube is taken out, and according to the needs of the internal irradiation treatment, a suitable inner tube of the applicator is inserted, the insertion angle of the inner tube is adjusted according to the positioning image, and the radioactive source channel is inserted into the inner tube.
  • a suitable inner tube of the applicator is inserted, the insertion angle of the inner tube is adjusted according to the positioning image, and the radioactive source channel is inserted into the inner tube.
  • different configurations of the inner tube of the applicator can be designed to accommodate different requirements for the number and location of the source channels.
  • a three-dimensional magnetic resonance scan is performed by inserting a positioning tube into the applicator tube and then inserting the site to be applied. Since the positioning tube can be highlighted in the three-dimensional magnetic resonance image, the applicator tube is in the three-dimensional magnetic resonance image. No longer black, it can clearly show the position of the outer tube of the applicator and the structure and lesions of the surrounding tissues and organs, provide better soft tissue contrast, better display the tissue characteristics of the lesion, and accurately design the radiotherapy plan, Providing a basis for accurately controlling the location and time of the radioactive source, the positioning device can accurately position the relative position of the lesion and the outer tube of the applicator under the highlight of the imaging agent, thereby improving the treatment efficiency and safety.
  • the embodiment of the present application further provides a magnetic resonance imaging based applicator, which can be used to implement the method described in the above embodiments, as described in the following embodiments. Since the principle of the magnetic resonance imaging-based applicator solves the problem is similar to the magnetic resonance imaging-based application position localization method, the implementation of the magnetic resonance imaging-based applicator can be referred to the magnetic resonance imaging-based application position localization method. Implementation, repetition will not be repeated.
  • the apparatus described in the following embodiments is preferably implemented in software, hardware, or a combination of software and hardware, is also possible and contemplated.
  • FIG. 2 is a schematic structural view of a magnetic resonance imaging-based applicator according to an embodiment of the present application.
  • the magnetic resonance imaging-based applicator includes a post-installer 10 (not shown), an applicator outer tube 20, a positioning tube 30 matched with the applicator outer tube, and a radioactive source.
  • Channel 40 wherein, as shown in FIG. 3, the positioning tube 30 is hollow, internally filled with a developer 31 for magnetic resonance imaging and a positioning device 32 for performing magnetic resonance imaging It is built in the outer tube 20 of the applicator, and is inserted into the application target site with the outer tube 20 of the applicator.
  • the three-dimensional magnetic resonance image can clearly show the tissue structure of the lesion and surrounding organs, but the outer tube of the applicator often appears black in the three-dimensional image because there is no signal in the magnetic resonance imaging. Therefore, in order to position the exact position of the outer tube of the applicator in the three-dimensional image, the above-mentioned positioning tube 30 matched with the outer tube of the applicator is specifically designed, as shown in FIG.
  • the applicator outer tube 20 of the present invention is made of an MRI compatible polymer material, and the positioning tube 30 is also made of a material suitable for magnetic resonance imaging.
  • the positioning tube 30 is filled with an imaging agent having a high signal to noise ratio under magnetic resonance
  • the imaging agent may be, for example, oil, water or other contrast enhancing agent suitable for magnetic resonance imaging ( Or imaging agent, contrast agent, etc., etc., are pre-closed and filled inside the positioning tube to ensure that the position of the application tube and the peripheral portion are highlighted in the three-dimensional magnetic resonance image.
  • the contrast enhancer is, for example, a complex of DTPA ( ⁇ -diethylenediaminepentaacetic acid) or the like.
  • the positioning device 32 can include an angular positioning device 321 and a depth positioning device 322 for determining the angle and depth of a target position relative to the outer tube of the applicator in the magnetic resonance imaging.
  • an angular positioning device 321 and a depth positioning device 322 for determining the angle and depth of a target position relative to the outer tube of the applicator in the magnetic resonance imaging.
  • a depth positioning device Surrounded by the imaging agent in Figure 3 is a depth positioning device of one embodiment. In the three-dimensional magnetic resonance image, not only the tissue structure of the lesion and the surrounding organs can be clearly displayed, but also the imaging agent inside the positioning tube can be presented.
  • the cross section of the positioning tube 30 is as shown in FIG. 4.
  • the positioning tube 30 further includes an angular positioning device 321 for determining the angular position of the outer tube of the applicator corresponding to the lesion.
  • the angular positioning device is realized, for example, by providing small protrusions (longitudinal strips, etc.) on the inner wall of the positioning tube, and the small protrusions are also displayed in black in the magnetic resonance image, because the positioning tube is filled with the developer, so the image is It is easy to accurately find the small convexity of the angle positioning.
  • more small convex structures can be designed to make the angular scale thinner.
  • Cross-section of the deep positioning device The features of the face vary with the cross-section at the positioning tube, for example the area or width of each cross-section of the depth positioning device corresponds one-to-one with the depth of the cross-section in the positioning tube.
  • the depth positioning device can have various designs, such as a reverse conical shape, and the principle is the same, and details are not described herein again.
  • the applicator further includes an applicator inner tube 50 that mates with the outer tube of the applicator.
  • 6 is a schematic longitudinal cross-sectional view of an inner tube of an applicator according to another embodiment of the present application
  • FIG. 7 is a cross-sectional view of the inner tube of the applicator according to another embodiment of the present application, as shown in FIG.
  • the inner tube 50 has one or more apertured channels therein for placing one or more source channels 40, which may be distributed differently.
  • the positioning tube 30, the applicator outer tube 20, and the applicator inner tube 50 are each made of a magnetic resonance imaging compatible polymer material with a preset precision scale on the surface.
  • the scale may include graduations of one or more dimensions, such as longitudinal depth and angular scale. The operator can accurately determine the depth of the inner tube of the applicator to be placed according to the scale, and in the three-dimensional magnetic resonance image, it can also assist in locating the position and deviation of the outer tube of the applicator.
  • the inner tube of the applicator When the radiation therapy is performed, the inner tube of the applicator is fixedly engaged with the outer tube of the applicator, and the source channel is inserted through a hole-shaped passage on the inner tube.
  • the specific card fastening method is designed according to actual needs, which is not limited in this application.
  • One end of the source channel 40 is connected to the after-loading machine 10 through a preset interface, and the other end is placed in the inner tube 50 of the applicator to be the treatment end of the lesion.
  • the radioactive source is introduced into a preset position in the source channel 40 according to the radiotherapy plan under computer control of the post-installation machine.
  • the applicator includes at least one set of the applicator outer tube 20 and a corresponding one of the positioning tubes 30.
  • the number of the outer tube 20 of the applicator is not limited according to the needs of the treatment, and each of the outer tubes 20 of the applicator is provided with an exact match (for example, matching of length, diameter, and interface connection).
  • the positioning tube 30, when performing three-dimensional magnetic resonance scanning, inserts each positioning tube into a corresponding application tube in advance, so that the position of each application tube can be located in the three-dimensional magnetic resonance image.
  • a three-dimensional magnetic resonance scan is performed by inserting a positioning tube into the outer tube of the applicator, and the three-dimensional magnetic resonance scan is performed in the three-dimensional magnetic resonance image, so that the outer tube of the applicator is in three-dimensional magnetic resonance.
  • the image is no longer black, and can accurately display the position of the outer tube of the applicator and the structure and lesions of surrounding tissues according to the positioning device, providing better soft tissue contrast and better representing the tissue characteristics of the lesion. It can accurately locate the position of the outer tube of the applicator and provide a basis for accurately designing the radiotherapy plan, accurately controlling the location and time of the radioactive source, and improving treatment efficiency and safety.
  • FIG. 8 is a schematic flow chart of a method for locating a position based on magnetic resonance imaging according to another embodiment of the present application. As shown in FIG. 8, the method includes:
  • step 201 the positioning tube is inserted into the outer tube of the applicator.
  • each set of positioning tubes and the outer tube of the applicator are matched with each other, and the outer tubes of different sizes of the applicators are provided with corresponding positioning tubes. Insert the positioning tube into the corresponding outer tube of the applicator, and several outer tubes of the applicator are inserted into several positioning tubes.
  • the size of the positioning tube is matched with the outer tube of the applicator, and the positioning tube is a hollow tube filled with the imaging agent and the positioning device with high signal to noise ratio under magnetic resonance.
  • the imaging agent may be oil, water or other contrast enhancing agent (or imaging agent, contrast agent, etc.) suitable for magnetic resonance imaging, pre-closed in the positioning tube to ensure high in the three-dimensional magnetic resonance image Lights up the position of the application tube.
  • the contrast enhancer is, for example, a complex of DTPA ( ⁇ -diethylenediaminepentaacetic acid) or the like.
  • Step 202 inserting the outer tube of the applicator inserted with the positioning tube into the application target site, and performing three-dimensional magnetic resonance imaging.
  • the disinfected positioning tube is first inserted into the outer tube of the applicator, and then the disinfected external tube of the applicator and the positioning tube are inserted into the patient body for magnetic resonance three-dimensional imaging.
  • the operator can estimate the position of the site to be administered based on experience or known information, and insert the outer tube of the applicator inserted with the positioning tube into the estimated target site.
  • Step 203 determining a source location according to the imaging agent and the positioning device in the positioning tube.
  • Three-dimensional magnetic resonance imaging is used to determine the position of the outer tube and the positioning tube of the applicator in the body, as well as the surrounding tissues and organs, to accurately assess the extent of the lesion and the relationship with the surrounding vital organs, on the basis of which individualized radiotherapy is developed.
  • the plan further determines the deviation of the position of the outer tube of the current applicator from the actual application position, and adjusts the position of the outer tube of the applicator.
  • the three-dimensional magnetic resonance image not only the tissue structure of the lesion and the surrounding organs can be clearly displayed, but also the imaging agent inside the positioning tube can be presented.
  • the positioning device comprises a depth positioning device and/or an angle positioning device
  • determining the application position according to the imaging agent and the positioning device in the positioning tube comprises: determining the application position according to the angular positioning device The relative angle of the outer tube of the applicator, and/or determining the relative depth of the source of application and the outer tube of the applicator according to the depth positioning device.
  • the angular positioning device is realized, for example, by providing small protrusions (longitudinal strips, etc.) on the inner wall of the positioning tube, and the small protrusions are also displayed in black in the magnetic resonance image, because the positioning tube is filled with the developer, so the image is It is easy to accurately find the small convexity of the angle positioning.
  • the depth positioning device varies with the cross-section at the positioning tube, for example, the area or width of each cross-section of the depth positioning device corresponds one-to-one with the depth of the cross-section in the positioning tube.
  • the depth positioning device as a conical shape as shown in FIG. 3
  • the depth position calculation method of one embodiment of the present application is as shown in FIG. 9.
  • the width of the depth positioning device can be measured.
  • the depth positioning device can be reverse designed, and the principle is the same. ,No longer.
  • Step 204 taking out the positioning tube.
  • the application tube is fixed at a determined application position, and the positioning tube is taken out.
  • Step 205 determining the number and distribution structure of the required source channels according to the application position.
  • the radiation treatment plan can be precisely designed, such as the irradiation position of the radiation source, the irradiation angle, the irradiation dose, etc., and the number and distribution structure of the radiation source channels are determined according to the actual radiation source placement requirements.
  • Step 206 Select the inner tube of the applicator corresponding to the source channel of the quantity and distribution structure.
  • the structure of the inner tube of the applicator is various, such as: the number of radioactive source channels on the inner tube of the applicator is different, and the distribution positions of the channels are different.
  • Step 207 Fix the applicator inner tube in the applicator outer tube according to the application position.
  • step 208 the source channel connected to the installed source is inserted into the corresponding inner tube of the applicator for radiation source irradiation.
  • the embodiment of the present application performs a three-dimensional magnetic resonance scan by inserting a positioning tube into the outer tube of the applicator and inserting the portion to be applied. Since the positioning tube can be highlighted in the three-dimensional magnetic resonance image, the outer tube of the applicator is in three dimensions.
  • the magnetic resonance image is no longer black, which can clearly show the position of the outer tube of the applicator and the structure and lesions of the surrounding tissues and organs, provide better soft tissue contrast, and better represent the tissue characteristics of the lesion, so that it can be accurately Position the external tube of the applicator and provide a basis for accurately designing the radiotherapy plan, accurately controlling the location and time of the radioactive source, and improving treatment accuracy and safety.
  • Any process or device description in the flowcharts or otherwise described herein can be understood as a module, segment or portion of code representing executable instructions including one or more steps for implementing a particular logical function or process.
  • the scope of preferred embodiments of the application includes Further implementations in which the functions may be performed in a substantially simultaneous manner or in an inverse order depending on the functions involved, which should be in accordance with the teachings of the embodiments of the present application. People understand.
  • portions of the application can be implemented in hardware, software, firmware, or a combination thereof.
  • multiple steps or means may be implemented in software or firmware stored in a memory and executed by a suitable instruction execution system.
  • a suitable instruction execution system For example, if implemented in hardware, as in another embodiment, it can be implemented by any one or combination of the following techniques well known in the art: having logic gates for implementing logic functions on data signals. Discrete logic circuits, application specific integrated circuits with suitable combinational logic gates, programmable gate arrays (PGAs), field programmable gate arrays (FPGAs), etc.

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Abstract

L'invention concerne un procédé de positionnement d'un applicateur basé sur une imagerie par résonance magnétique (IRM), et un applicateur. Le procédé consiste: à insérer un tube de positionnement (30) dans un tube applicateur externe (20); à insérer le tube applicateur externe (20) contenant le tube de positionnement (30) dans une partie cible en vue de l'application d'une source, et à réaliser une imagerie par résonance magnétique tridimensionnelle (102); et à déterminer une position d'application (103) en fonction d'un agent d'imagerie (31) et de dispositifs de positionnement (321, 322) présents dans le tube de positionnement (30). Le procédé de l'invention permet de localiser avec précision la position d'un tube applicateur externe (20) dans une image IRM, et d'afficher distinctement des changements morphologiques ou pathologiques de tissus ou d'organes à la périphérie du tube applicateur externe (20), ce qui améliore la précision de positionnement.
PCT/CN2016/100309 2016-09-27 2016-09-27 Procédé de positionnement d'un applicateur basé sur une imagerie par résonance magnétique, et applicateur WO2018058292A1 (fr)

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CN101152090A (zh) * 2007-09-22 2008-04-02 泸州医学院附属医院 可用于ct扫描的宫颈癌单管式后装施源器
CN201871125U (zh) * 2010-10-31 2011-06-22 陈萍 食管癌后装施源器
CN201848022U (zh) * 2010-11-17 2011-06-01 山东省肿瘤防治研究院 一种用于食管癌近距离放疗的施源器
US20130053682A1 (en) * 2011-08-31 2013-02-28 Jacqueline Esthappan Gynecological brachytherapy applicator for use in mr-guided intracavitary brachytherapy
CN104994908A (zh) * 2012-12-12 2015-10-21 核通运营有限公司 近距离放射治疗仪器、成像系统以及图像采集的方法
CN106334275A (zh) * 2016-09-27 2017-01-18 深圳先进技术研究院 基于磁共振成像的施源位置定位方法和施源器

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CN109363769A (zh) * 2018-11-13 2019-02-22 李成利 一种磁共振定位装置及定位方法
CN109363769B (zh) * 2018-11-13 2024-02-23 李成利 一种磁共振定位装置及定位方法
CN112057736A (zh) * 2020-09-18 2020-12-11 张鲁燕 一种宫颈癌后装放疗施源器

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