WO2018058291A1 - Procédé de positionnement d'un applicateur basé sur une imagerie par résonance magnétique, et applicateur - Google Patents

Procédé de positionnement d'un applicateur basé sur une imagerie par résonance magnétique, et applicateur Download PDF

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Publication number
WO2018058291A1
WO2018058291A1 PCT/CN2016/100308 CN2016100308W WO2018058291A1 WO 2018058291 A1 WO2018058291 A1 WO 2018058291A1 CN 2016100308 W CN2016100308 W CN 2016100308W WO 2018058291 A1 WO2018058291 A1 WO 2018058291A1
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WO
WIPO (PCT)
Prior art keywords
applicator
tube
magnetic resonance
positioning
resonance imaging
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Application number
PCT/CN2016/100308
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English (en)
Chinese (zh)
Inventor
朱艳春
谢耀钦
李硕
杨洁
刘云
Original Assignee
深圳先进技术研究院
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Application filed by 深圳先进技术研究院 filed Critical 深圳先进技术研究院
Priority to PCT/CN2016/100308 priority Critical patent/WO2018058291A1/fr
Publication of WO2018058291A1 publication Critical patent/WO2018058291A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

Definitions

  • the present application relates to the field of applicator positioning technologies, and in particular, to a method and a source device for applying a position based on magnetic resonance imaging.
  • the positioning of the applicator is usually obtained by a positive lateral radiograph or a three-dimensional computed tomography (CT) scan.
  • CT computed tomography
  • MRI Magnetic Resonance Imaging
  • Post-loading radiation therapy refers to placing a treatment container (applicator) without a radioactive source on the treatment site, and the computer remote-controlled stepper motor (post-installation machine) sends the radioactive source to the applicator for radiation therapy, so as to avoid prevention. Medical staff were injured by radiation during the treatment.
  • the function of the post-installation machine is to place the radioactive source accurately, safely and regularly into the human lesion through the application tube.
  • Post-loading therapy is an auxiliary treatment for external irradiation.
  • the dose at the near-source is much larger than the distance from the far source.
  • tumor tissue can achieve an effective killing dose, while adjacent normal tissues can be protected. It can be seen that one of the quality assurances of the post-loading treatment is the accuracy of the radioactive source, which directly affects the therapeutic effect.
  • the workflow of the post-loading treatment is to insert the disinfected application tube into the patient's treatment site according to the doctor's diagnosis result, and fix it; then, use the simulator to take a positive lateral radiograph or 3D CT image, locate the position of the application tube, formulate the optimal treatment time at each point, design the treatment plan; connect the application tube with the post-loading treatment machine, and then perform the radiotherapy plan through the operation and installation control system; After the amount of irradiation, under the control of the post-installation computer, the radioactive source automatically returns to the reservoir and completes a close-in post-loading treatment.
  • magnetic resonance imaging has the advantages of no radiation, high resolution, high soft tissue contrast, etc., which makes magnetic resonance imaging more and more attention.
  • the positive side X-ray film is taken by the simulator, and the treatment plan is made according to the coordinate reconstruction result.
  • the treatment plan is simple, the dose accuracy is very low, and the lesion range and the normal tissue cannot be correctly evaluated.
  • the situation in turn gives a personalized and precise radiotherapy dosage regimen.
  • CT three-dimensional imaging can achieve the positioning of the applicator and develop a precise radiotherapy plan, but the soft tissue contrast of the CT image is poor, and usually the internal irradiation therapy is for the soft tissue cavity, and the CT image is not well presented.
  • the three-dimensional magnetic resonance image can clearly show the structure of the lesion and surrounding organs, but the current application of the polymer tube for magnetic resonance imaging is often not because of magnetic resonance imaging.
  • the signal is reflected in black on the three-dimensional image, which results in the magnetic resonance three-dimensional image not being able to exert its original advantages to accurately locate the position of the application tube, and also affects the observability of the surrounding tissue lesions.
  • an object of the present application is to provide a magnetic resonance imaging-based application position localization method and an applicator for accurately positioning a position of a source pipe in a magnetic resonance image, and Clearly show the shape and pathological changes of the tissues and organs around the pipe of the applicator, and effectively improve the treatment accuracy.
  • the magnetic resonance imaging-based application position localization method proposed by the embodiment of the present application includes: inserting a positioning tube into the applicator tube; and inserting the applicator tube inserted with the positioning tube into the application site to be applied And performing three-dimensional magnetic resonance imaging; determining a source position and a feeding scheme according to the imaging agent in the positioning tube, and positioning the applicator tube at the application position.
  • a magnetic resonance imaging-based applicator includes a post-installer and a source pipe, and the applicator further includes a positioning pipe matched with the applicator pipe, wherein The positioning tube is hollow and internally filled with an imaging agent for magnetic resonance imaging, and the positioning tube is used to be built in the applicator tube during magnetic resonance imaging, and is inserted with the applicator tube Source target location.
  • the applicator tube can be highlighted in the three-dimensional magnetic resonance imaging, which can be accurately Positioning the applicator tube clearly shows the morphological structure and pathological changes of the diseased tissue and surrounding tissues and organs, providing better soft tissue contrast and better showing the tissue characteristics of the lesion, so that the position of the applicator tube can be accurately located.
  • FIG. 1 is a schematic flow chart of a method for locating a position based on magnetic resonance imaging according to an embodiment of the present application
  • FIG. 2 is a schematic structural view of a magnetic resonance imaging based applicator according to an embodiment of the present application
  • FIG. 3 is a schematic diagram of a positioning tube of a magnetic resonance imaging based applicator according to an embodiment of the present application
  • FIG. 4 is a schematic diagram of a donor tube of a magnetic resonance imaging-based applicator according to an embodiment of the present application
  • FIG. 5 is a schematic flow chart of a method for locating a position based on magnetic resonance imaging according to another embodiment of the present application.
  • Embodiments of the present application provide a method and device for applying a position based on magnetic resonance imaging.
  • FIG. 1 is a schematic flow chart of a method for locating a position based on magnetic resonance imaging according to an embodiment of the present application. As shown in FIG. 1, the method includes:
  • step 101 the positioning tube is inserted into the applicator tube.
  • the positioning tube is matched with the applicator tube, and the differently sized applicator tubes are provided with corresponding positioning tubes, which can be highlighted in three-dimensional magnetic resonance imaging.
  • Step 102 inserting the applicator tube inserted with the positioning tube into the site to be applied, and performing three-dimensional magnetic resonance imaging.
  • Step 103 Determine a source position and a feeding scheme according to the imaging agent in the positioning tube, and position the applicator tube at the application position.
  • the applicator tube of the present invention is made of MRI compatible polymer material, and the positioning tube is also made of a material suitable for magnetic resonance imaging.
  • the positioning tube is a hollow tube internally filled with the imaging agent having a high signal to noise ratio under magnetic resonance.
  • the developer can be oil, water or other suitable for magnetic common
  • the contrast-enhanced contrast enhancer (or imaging agent, contrast agent, etc.) is pre-blocked and filled in the positioning tube to ensure that the position of the application tube is highlighted in the three-dimensional magnetic resonance image.
  • the contrast enhancer is, for example, a complex of DTPA ( ⁇ -diethylenediaminepentaacetic acid) or the like.
  • the three-dimensional magnetic resonance localization treatment has a lower radiation and provides better soft tissue contrast than existing CT-guided internal illumination treatments. Since the internal irradiation treatment is mainly for treating the cavity lesions in the human body, the better presentation of the diseased tissue and the peripheral organs is the basic condition for formulating a precise radiotherapy plan.
  • a three-dimensional magnetic resonance scan is performed by inserting a positioning tube into the applicator tube and then inserting the site to be applied. Since the positioning tube can be highlighted in the three-dimensional magnetic resonance image, the applicator tube is in the three-dimensional magnetic resonance image. No longer black, it can clearly show the position of the applicator tube and the structure and lesions of the surrounding tissues and organs, provide better soft tissue contrast, better display the tissue characteristics of the lesion, so that the applicator tube can be accurately positioned.
  • the embodiment of the present application further provides a magnetic resonance imaging based applicator, which can be used to implement the method described in the above embodiments, as described in the following embodiments. Since the principle of the magnetic resonance imaging-based applicator solves the problem is similar to the magnetic resonance imaging-based application position localization method, the implementation of the magnetic resonance imaging-based applicator can be referred to the magnetic resonance imaging-based application position localization method. Implementation, repetition will not be repeated.
  • the apparatus described in the following embodiments is preferably implemented in software, hardware, or a combination of software and hardware, is also possible and contemplated.
  • FIG. 2 is a schematic structural view of a magnetic resonance imaging-based applicator according to an embodiment of the present application.
  • the magnetic resonance imaging-based applicator includes a post-installer 10 (not shown), an applicator tube 20, and a positioning tube 30 that matches the applicator tube, wherein As shown in FIG. 3, the positioning tube 30 is hollow and internally filled with a developer 31 for magnetic resonance imaging.
  • the positioning tube 30 is used to be built into the applicator tube 20 during magnetic resonance imaging, with the applicator tube 20 being inserted into the application target position.
  • the applicator tube 20 of the present invention is made of an MRI compatible polymer material, and the positioning tube 30 is also made of a material suitable for magnetic resonance imaging.
  • the positioning tube 30 is a hollow tube that is internally filled with the imaging agent that exhibits a high signal to noise ratio under magnetic resonance.
  • the imaging agent may be oil, water or other contrast enhancing agent (or imaging agent, contrast agent, etc.) suitable for magnetic resonance imaging, and is pre-closed and filled inside the positioning tube to ensure high in the three-dimensional magnetic resonance image.
  • the contrast enhancer is, for example, a complex of DTPA ( ⁇ -diethylenediaminepentaacetic acid) or the like.
  • the source pipe 20 is closed at one end, and is a radiation therapy end 21 for placing a radiation source, and the other end has an interface 22 matching the post-installation machine 10.
  • the inside of the pipe is a source channel 23, and during the treatment, the post-installer 10 passes through the interface 22.
  • the radioactive source is introduced under a computer control to a predetermined position of the radiation therapy end 21 in the source channel 23 in accordance with a radiotherapy plan.
  • the applicator tube is made of a magnetic resonance imaging compatible polymer material, and the surface is provided with a preset precision scale.
  • the operator can accurately determine the depth of the application tube to be placed according to the scale on the applicator tube (referred to as the application tube), and in the 3D magnetic resonance image, can also assist in locating the position of the application tube. And deviation.
  • the applicator includes at least one set of the applicator tube 20 and a corresponding one of the positioning tubes 30.
  • the number of the applicator tubes 20 is not limited to one according to the needs of the treatment, and each of the applicator tubes 20 is provided with an exact match (for example, matching of length, diameter, and interface connection).
  • the positioning tube 30 inserts each positioning tube into a corresponding application tube in advance when performing three-dimensional magnetic resonance scanning, so that the position of each application tube can be located in the three-dimensional magnetic resonance image.
  • a three-dimensional magnetic resonance scan is performed by inserting a positioning tube into the applicator tube and then inserting the site to be applied, since the positioning tube can be highlighted in the three-dimensional magnetic resonance image, so that the applicator tube
  • the channel is no longer black in the 3D magnetic resonance image, which clearly shows the position of the applicator tube and the structure and lesions of the surrounding tissues and organs, provides better soft tissue contrast, and better presents the tissue characteristics of the lesion. It can precisely locate the location of the applicator tube and provide a basis for accurately designing the radiotherapy plan, accurately controlling the location and timing of the radioactive source, and improving treatment efficiency and safety.
  • FIG. 5 is a schematic flowchart of a magnetic resonance imaging-based application position localization method according to another embodiment of the present application. As shown in FIG. 5, the method includes:
  • step 501 the positioning tube is inserted into the applicator tube.
  • each set of positioning tubes and the applicator tubes are matched with each other, and the differently sized applicator tubes are provided with corresponding positioning tubes. Insert the positioning tube into the corresponding applicator tube, and several applicator tubes are inserted into several positioning tubes.
  • Step 502 inserting the applicator tube inserted with the positioning tube into the site to be applied, and performing three-dimensional magnetic resonance imaging.
  • Step 503 determining a source location and a feeding scheme according to the imaging agent in the positioning tube, and positioning the applicator tube at the application position.
  • the operator can estimate the position of the site to be applied according to experience or known information, insert the applicator tube inserted with the positioning tube into the estimated source to be applied, and determine by three-dimensional magnetic resonance scanning imaging.
  • the condition of the tissue and organs around the current position of the source tube is determined, and the radiotherapy plan is determined, thereby determining the deviation of the position of the current applicator tube from the actual position to be applied, and adjusting the position of the application tube.
  • the three-dimensional magnetic resonance image the extent of the lesion and the relationship between the diseased tissue and the surrounding vital organs can be accurately evaluated, and an individualized radiation treatment plan can be formulated to determine the applicable irradiation dose in each application tube.
  • step 504 the positioning tube is taken out.
  • the application tube After the position of the application tube is adjusted, the application tube is fixed at the position to be applied, and the positioning tube is taken out.
  • Step 505 connecting the post-installation machine to the applicator tube, and performing radiation source irradiation according to the application scheme.
  • the application scheme may include a plurality of parameters such as a feeding position, an irradiation time, and the like, and a rear mounting interface at one end of the application tube is connected to the rear mounting machine, and the radioactive source is introduced into the application pipeline under computer control, and according to the The proposed protocol is for radiation therapy. After the quantitative irradiation (end of treatment) is completed, the radioactive source is returned to the computer under the control of the computer, and then the radiotherapy is completed.
  • the embodiment of the present application performs a three-dimensional magnetic resonance scan by inserting a positioning tube into the applicator tube and inserting the site to be applied. Since the positioning tube can be highlighted in the three-dimensional magnetic resonance image, the applicator tube is subjected to three-dimensional magnetic resonance. The image is no longer black, which clearly shows the position of the applicator tube and the structure and lesions of surrounding tissues and organs, provides better soft tissue contrast, better presents the tissue characteristics of the lesion, and thus can accurately locate the application.
  • the location of the tube and the basis for accurate design of the radiotherapy plan, accurate control of the location and time of the radio source, improve treatment accuracy and safety.
  • portions of the application can be implemented in hardware, software, firmware, or a combination thereof.
  • multiple steps or means may be implemented in software or firmware stored in a memory and executed by a suitable instruction execution system.
  • a suitable instruction execution system For example, if implemented in hardware, as in another embodiment, it can be implemented by any one or combination of the following techniques well known in the art: having logic gates for implementing logic functions on data signals.
  • Discrete logic circuit An application specific integrated circuit with a suitable combination of logic gates, a programmable gate array (PGA), a field programmable gate array (FPGA), and the like.

Abstract

L'invention concerne un procédé de positionnement d'un applicateur basé sur une imagerie par résonance magnétique (IRM), et un applicateur. Le procédé consiste: à insérer un tube de positionnement (30) dans un récipient d'applicateur (20); à insérer le récipient d'applicateur (20) contenant le tube de positionnement (30) dans une partie à laquelle une source doit être appliquée, et à réaliser une imagerie par résonance magnétique tridimensionnelle (102); à déterminer, en fonction d'un agent d'imagerie (31) présent dans le tube de positionnement (30), une position d'application et un schéma d'application, et à positionner le récipient d'applicateur (20) au niveau de la position d'application (103). Le procédé de l'invention permet de localiser avec précision la position d'un récipient d'applicateur (20) dans une image IRM, et d'afficher distinctement des changements morphologiques ou pathologiques de tissus ou d'organes à la périphérie du récipient d'applicateur (20), ce qui améliore la précision d'un traitement.
PCT/CN2016/100308 2016-09-27 2016-09-27 Procédé de positionnement d'un applicateur basé sur une imagerie par résonance magnétique, et applicateur WO2018058291A1 (fr)

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PCT/CN2016/100308 WO2018058291A1 (fr) 2016-09-27 2016-09-27 Procédé de positionnement d'un applicateur basé sur une imagerie par résonance magnétique, et applicateur

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Cited By (2)

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CN114053600A (zh) * 2021-11-12 2022-02-18 江苏海明医疗器械有限公司 一种后装放射治疗机用出源长度测量系统
CN116152437A (zh) * 2023-02-13 2023-05-23 北京医智影科技有限公司 施源器重建方法、装置、电子设备和计算机可读存储介质

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CN2912675Y (zh) * 2006-06-15 2007-06-20 卢金利 双腔水囊型食道施源器
US20080119784A1 (en) * 2006-11-17 2008-05-22 Suranjan Roychowdhury Systems, Apparatus and Associated Methods for Needleless Delivery of Therapeutic Fluids
CN101152090A (zh) * 2007-09-22 2008-04-02 泸州医学院附属医院 可用于ct扫描的宫颈癌单管式后装施源器
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Publication number Priority date Publication date Assignee Title
CN114053600A (zh) * 2021-11-12 2022-02-18 江苏海明医疗器械有限公司 一种后装放射治疗机用出源长度测量系统
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CN116152437A (zh) * 2023-02-13 2023-05-23 北京医智影科技有限公司 施源器重建方法、装置、电子设备和计算机可读存储介质
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