WO2018058292A1

WO2018058292A1 - Applicator positioning method based on magnetic resonance imaging, and applicator

Info

Publication number: WO2018058292A1
Application number: PCT/CN2016/100309
Authority: WO
Inventors: 朱艳春; 谢耀钦; 熊璟; 付楠; 陈昳丽; 王磊
Original assignee: 深圳先进技术研究院
Priority date: 2016-09-27
Filing date: 2016-09-27
Publication date: 2018-04-05

Abstract

An applicator positioning method based on magnetic resonance imaging (MRI), and applicator. The method comprises: inserting a positioning tube (30) into an outer applicator tube (20) (101); inserting the outer applicator tube (20) inserted with the positioning tube (30) into a target portion for source application, and performing three-dimensional magnetic resonance imaging (102); and determining, according to an imaging agent (31) and positioning devices (321, 322) in the positioning tube (30), an application position (103). The method of the present invention enables the position of an outer applicator tube (20) to be accurately located in an MRI image, and clearly displays morphology and pathological changes of tissues and organs in a periphery of the outer applicator tube (20), thus improving the precision of positioning.

Description

Magnetic resonance imaging based source location method and applicator

Technical field

The present application relates to the field of applicator positioning technologies, and in particular, to a method and a source device for applying a position based on magnetic resonance imaging.

Background technique

Clinically, during the post-loading treatment, the positioning of the applicator is usually obtained by a positive lateral radiograph or a three-dimensional computed tomography (CT) scan. With the development of Magnetic Resonance Imaging (MRI), its advantages of no radiation, high resolution, and high soft tissue contrast make it more and more widely used.

After the 1970s, post-loading radiation therapy was developed, especially in gynecological intracavitary radiotherapy. In the late 1980s, the reactor produced a high-strength micro-铱-192 source, and the development of computer control gradually through the initial mechanical and motor stages, which made the post-loading treatment enter a new stage. Post-loading radiation therapy refers to placing a treatment container (applicator) without a radioactive source on the treatment site, and the computer remote-controlled stepper motor (post-installation machine) sends the radioactive source to the applicator for radiation therapy, so as to avoid prevention. Medical staff were injured by radiation during the treatment. Due to the advantages of accurate placement and close proximity to the body tissue, significant clinical effects have been achieved in the treatment of gynecological, nasopharyngeal, esophageal, bronchial, rectal, bladder, breast and pancreatic tumors. The function of the post-installation machine is to place the radioactive source accurately, safely and regularly into the human lesion through the application tube.

Post-loading therapy is an auxiliary treatment for external irradiation. According to the inverse square law, the dose at the near-source is much larger than the distance from the far source. Using this feature, tumor tissue can achieve an effective killing dose, while adjacent normal tissues can be protected. It can be seen that one of the quality assurances of the post-loading treatment is the accuracy of the radioactive source, which directly affects the therapeutic effect.

At present, the workflow of the post-loading treatment is to insert the disinfected application tube into the patient's treatment site according to the doctor's diagnosis result, and fix it; then, the positive side X-ray is taken by the simulator. Tablet or 3D CT image, locate the position of the application tube, formulate the optimal treatment time at each point, design the treatment plan; connect the application tube with the post-loading treatment machine, and then perform the radiotherapy plan through the operation of the installed machine control system; After a certain amount of irradiation is completed, under the control of the post-installation computer, the radioactive source automatically returns to the reservoir and completes a close-in post-loading treatment.

With the development of magnetic resonance imaging technology, magnetic resonance imaging has the advantages of no radiation, high resolution, high soft tissue contrast, etc., which makes magnetic resonance imaging more and more attention. Clinically, the positive side X-ray film is taken by the simulator, and the treatment plan is made according to the coordinate reconstruction result. Although the post-installation internal irradiation treatment can be realized, the treatment plan is simple, the dose accuracy is very low, and the lesion range and the normal tissue cannot be correctly evaluated. The situation in turn gives a personalized and precise radiotherapy dosage regimen.

Chinese patent CN101152090A has published a "single-tube post-loading device for cervical cancer that can be used for CT scanning", which can scan and image the cervical cancer posterior device, which includes a hollow source pipe. One end of the pipeline is connected with the rear application tube, and the other end is a lesion treatment end. The treatment end is composed of an elliptical inner tube made of a shielding functional material, and a circular hole is arranged in the center of the inner tube, and the circular hole is The application pipeline is connected, and the movable sleeve is also provided with a cylindrical outer tube made of CT-compatible polymer material. The invention can obtain a three-dimensional image of the lesion by CT scanning, thereby accurately estimating the lesion. The scope and surrounding normal tissue conditions provide an image data basis for individualized and accurate radiotherapy.

At present, CT three-dimensional imaging can realize the positioning of the applicator and develop a precise radiotherapy plan, but the CT image soft tissue contrast is poor, and usually the internal irradiation therapy is for the soft tissue cavity, and the CT image is not well presented. According to the principle of magnetic resonance imaging, the three-dimensional magnetic resonance image can clearly show the structure of the lesion and surrounding organs, but the current application of the polymer tube for magnetic resonance imaging is often not because of magnetic resonance imaging. The signal is reflected in black on the three-dimensional image, which results in the magnetic resonance three-dimensional image not being able to exert its original advantages to accurately locate the position of the application tube, and also affects the observability of the surrounding tissue lesions.

Summary of the invention

In order to solve the above problems in the prior art, an object of the present application is to provide a magnetic resonance imaging-based application position localization method and an applicator for accurately positioning a position of a source pipe in a magnetic resonance image, and Clearly show the shape and pathological changes of the tissues and organs around the pipe of the applicator, and effectively improve the treatment accuracy.

In order to achieve the above object, the magnetic resonance imaging-based application position localization method proposed by the embodiment of the present application includes: inserting a positioning tube into the outer tube of the applicator; inserting the outer tube of the applicator inserted with the positioning tube into the application source The target site is subjected to three-dimensional magnetic resonance imaging; the application position is determined according to the imaging agent and the positioning device in the positioning tube.

In order to achieve the above object, a magnetic resonance imaging-based applicator according to an embodiment of the present application includes a post-installation machine, a radioactive source channel, and an applicator outer tube, and the applicator further includes matching the outer tube of the applicator. Positioning tube, wherein the positioning tube is hollow, internally filled with a developer for magnetic resonance imaging and a positioning device for being built into the outer tube of the applicator during magnetic resonance imaging Insert the application target site with the outer tube of the applicator.

It can be seen from the technical solution provided by the above embodiments of the present application that by inserting a positioning tube into the applicator tube and inserting a to-be-applied portion for three-dimensional magnetic resonance scanning, the applicator tube can be highlighted in the three-dimensional magnetic resonance imaging, which can be accurately Positioning the position of the applicator tube and the relative angle and relative depth of the application site and the application tube clearly show the morphological structure and pathological changes of the diseased tissue and surrounding tissues and organs, providing better soft tissue contrast and better showing the lesion The tissue characteristics allow precise positioning of the applicator tubing and provide a basis for precise design of the radiotherapy plan, accurate control of where the radioactive source resides and time, and improved treatment accuracy and safety.

The aspects and advantages of the present invention will be set forth in part in the description which follows.

DRAWINGS

In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings used in the embodiments or the prior art description will be briefly introduced below, and it is obvious that The drawings in the following description are only some of the embodiments of the present application, and those skilled in the art can obtain other drawings according to the drawings without any creative work.

1 is a schematic flow chart of a method for locating a position based on magnetic resonance imaging according to an embodiment of the present application;

2 is a schematic structural view of a magnetic resonance imaging based applicator according to an embodiment of the present application;

3 is a schematic diagram of a positioning tube of a magnetic resonance imaging based applicator according to an embodiment of the present application;

4 is a schematic cross-sectional view of a positioning tube of a magnetic resonance imaging-based applicator according to an embodiment of the present application;

5 is a schematic diagram of a magnetic resonance imaging based applicator of another embodiment of the present application;

Figure 6 is a longitudinal sectional view of the inner tube of the applicator according to another embodiment of the present application;

Figure 7 is a cross-sectional view showing the inner tube of the applicator of another embodiment of the present application;

FIG. 8 is a schematic flow chart of a method for locating a position based on magnetic resonance imaging according to another embodiment of the present application; FIG.

FIG. 9 is a schematic diagram of a model for depth position calculation of a magnetic resonance imaging based application position according to another embodiment of the present application.

detailed description

Embodiments of the present application provide a method and device for applying a position based on magnetic resonance imaging.

The technical solutions in the embodiments of the present application are clearly and completely described in the following, in which the technical solutions in the embodiments of the present application are clearly and completely described. The embodiment is only a part of the embodiment of the present application, not the whole An embodiment of the department. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments of the present application without departing from the inventive scope shall fall within the scope of the application.

1 is a schematic flow chart of a method for locating a position based on magnetic resonance imaging according to an embodiment of the present application. As shown in FIG. 1, the method includes:

In step 101, the positioning tube is inserted into the applicator tube.

Specifically, the positioning tube is matched with the applicator tube, and the differently sized applicator tubes are provided with corresponding positioning tubes, which can be highlighted in three-dimensional magnetic resonance imaging.

Step 102, inserting the outer tube of the applicator inserted with the positioning tube into the application target site, and performing three-dimensional magnetic resonance imaging.

Step 103: Determine a source location according to the imaging agent and the positioning device in the positioning tube.

The applicator tube of the present invention is made of MRI compatible polymer material, and the positioning tube is also made of a material suitable for magnetic resonance imaging.

According to an embodiment of the present application, the positioning tube is sized to match the outer tube of the applicator, the positioning tube being a hollow tube filled with the imaging agent and positioning device having a high signal to noise ratio under magnetic resonance. Wherein, the imaging agent may be oil, water or other contrast enhancing agent (or imaging agent, contrast agent, etc.) suitable for magnetic resonance imaging, pre-closed in the positioning tube to ensure high in the three-dimensional magnetic resonance image Lights up the position of the application tube. The contrast enhancer is, for example, a complex of DTPA (钆-diethylenediaminepentaacetic acid) or the like. Wherein, the positioning device may comprise an angular positioning device and a depth positioning device for determining the angle and depth of a certain target position in the magnetic resonance imaging with respect to the outer tube of the applicator.

It is to be understood that the three-dimensional magnetic resonance localization treatment has a lower radiation and provides better soft tissue contrast than existing CT-guided internal illumination treatments. Since the internal irradiation treatment is mainly for treating the cavity lesions in the human body, it is better to present the diseased tissue and the peripheral organs, which is the basic condition for formulating an accurate radiotherapy treatment plan.

In practical application, the outer tube of the applicator is inserted into the patient body in advance, and the positioning tube for the magnetic resonance imaging positioning and the outer tube of the applicator is inserted into the outer tube. Since the positioning tube is designed with a positioning device, The positioning tube is filled with a magnetic resonance imaging agent to ensure accurate display of the position of the outer tube of the applicator in the 3D magnetic resonance image. The three-dimensional magnetic resonance scan is completed, and a treatment plan for radiation therapy is prepared according to the condition of the diseased tissue and the normal tissue or organ in the three-dimensional magnetic resonance image and the position of the outer tube of the applicator. Then, the positioning tube is taken out, and according to the needs of the internal irradiation treatment, a suitable inner tube of the applicator is inserted, the insertion angle of the inner tube is adjusted according to the positioning image, and the radioactive source channel is inserted into the inner tube. For different treatment needs, different configurations of the inner tube of the applicator can be designed to accommodate different requirements for the number and location of the source channels.

In this embodiment, a three-dimensional magnetic resonance scan is performed by inserting a positioning tube into the applicator tube and then inserting the site to be applied. Since the positioning tube can be highlighted in the three-dimensional magnetic resonance image, the applicator tube is in the three-dimensional magnetic resonance image. No longer black, it can clearly show the position of the outer tube of the applicator and the structure and lesions of the surrounding tissues and organs, provide better soft tissue contrast, better display the tissue characteristics of the lesion, and accurately design the radiotherapy plan, Providing a basis for accurately controlling the location and time of the radioactive source, the positioning device can accurately position the relative position of the lesion and the outer tube of the applicator under the highlight of the imaging agent, thereby improving the treatment efficiency and safety.

Based on the same inventive concept, the embodiment of the present application further provides a magnetic resonance imaging based applicator, which can be used to implement the method described in the above embodiments, as described in the following embodiments. Since the principle of the magnetic resonance imaging-based applicator solves the problem is similar to the magnetic resonance imaging-based application position localization method, the implementation of the magnetic resonance imaging-based applicator can be referred to the magnetic resonance imaging-based application position localization method. Implementation, repetition will not be repeated. Although the apparatus described in the following embodiments is preferably implemented in software, hardware, or a combination of software and hardware, is also possible and contemplated.

2 is a schematic structural view of a magnetic resonance imaging-based applicator according to an embodiment of the present application.

As shown in FIG. 2, the magnetic resonance imaging-based applicator includes a post-installer 10 (not shown), an applicator outer tube 20, a positioning tube 30 matched with the applicator outer tube, and a radioactive source. Channel 40, wherein, as shown in FIG. 3, the positioning tube 30 is hollow, internally filled with a developer 31 for magnetic resonance imaging and a positioning device 32 for performing magnetic resonance imaging It is built in the outer tube 20 of the applicator, and is inserted into the application target site with the outer tube 20 of the applicator.

According to the principle of magnetic resonance imaging, the three-dimensional magnetic resonance image can clearly show the tissue structure of the lesion and surrounding organs, but the outer tube of the applicator often appears black in the three-dimensional image because there is no signal in the magnetic resonance imaging. Therefore, in order to position the exact position of the outer tube of the applicator in the three-dimensional image, the above-mentioned positioning tube 30 matched with the outer tube of the applicator is specifically designed, as shown in FIG. The applicator outer tube 20 of the present invention is made of an MRI compatible polymer material, and the positioning tube 30 is also made of a material suitable for magnetic resonance imaging. In one embodiment of the invention, the positioning tube 30 is filled with an imaging agent having a high signal to noise ratio under magnetic resonance, and the imaging agent may be, for example, oil, water or other contrast enhancing agent suitable for magnetic resonance imaging ( Or imaging agent, contrast agent, etc., etc., are pre-closed and filled inside the positioning tube to ensure that the position of the application tube and the peripheral portion are highlighted in the three-dimensional magnetic resonance image. The contrast enhancer is, for example, a complex of DTPA (钆-diethylenediaminepentaacetic acid) or the like.

Further, the positioning device 32 can include an angular positioning device 321 and a depth positioning device 322 for determining the angle and depth of a target position relative to the outer tube of the applicator in the magnetic resonance imaging. Surrounded by the imaging agent in Figure 3 is a depth positioning device of one embodiment. In the three-dimensional magnetic resonance image, not only the tissue structure of the lesion and the surrounding organs can be clearly displayed, but also the imaging agent inside the positioning tube can be presented. The cross section of the positioning tube 30 is as shown in FIG. 4. The positioning tube 30 further includes an angular positioning device 321 for determining the angular position of the outer tube of the applicator corresponding to the lesion. The angular positioning device is realized, for example, by providing small protrusions (longitudinal strips, etc.) on the inner wall of the positioning tube, and the small protrusions are also displayed in black in the magnetic resonance image, because the positioning tube is filled with the developer, so the image is It is easy to accurately find the small convexity of the angle positioning. In practice, in order to facilitate direct observation of the angle, more small convex structures can be designed to make the angular scale thinner. Cross-section of the deep positioning device The features of the face vary with the cross-section at the positioning tube, for example the area or width of each cross-section of the depth positioning device corresponds one-to-one with the depth of the cross-section in the positioning tube. In the actual design, the depth positioning device can have various designs, such as a reverse conical shape, and the principle is the same, and details are not described herein again.

In an embodiment of the present application, as shown in FIG. 5, the applicator further includes an applicator inner tube 50 that mates with the outer tube of the applicator. 6 is a schematic longitudinal cross-sectional view of an inner tube of an applicator according to another embodiment of the present application, and FIG. 7 is a cross-sectional view of the inner tube of the applicator according to another embodiment of the present application, as shown in FIG. The inner tube 50 has one or more apertured channels therein for placing one or more source channels 40, which may be distributed differently.

In a specific embodiment, the positioning tube 30, the applicator outer tube 20, and the applicator inner tube 50 are each made of a magnetic resonance imaging compatible polymer material with a preset precision scale on the surface. The scale may include graduations of one or more dimensions, such as longitudinal depth and angular scale. The operator can accurately determine the depth of the inner tube of the applicator to be placed according to the scale, and in the three-dimensional magnetic resonance image, it can also assist in locating the position and deviation of the outer tube of the applicator.

When the radiation therapy is performed, the inner tube of the applicator is fixedly engaged with the outer tube of the applicator, and the source channel is inserted through a hole-shaped passage on the inner tube. The specific card fastening method is designed according to actual needs, which is not limited in this application. One end of the source channel 40 is connected to the after-loading machine 10 through a preset interface, and the other end is placed in the inner tube 50 of the applicator to be the treatment end of the lesion. At the time of treatment, the radioactive source is introduced into a preset position in the source channel 40 according to the radiotherapy plan under computer control of the post-installation machine.

According to an embodiment of the present application, the applicator includes at least one set of the applicator outer tube 20 and a corresponding one of the positioning tubes 30. Specifically, the number of the outer tube 20 of the applicator is not limited according to the needs of the treatment, and each of the outer tubes 20 of the applicator is provided with an exact match (for example, matching of length, diameter, and interface connection). The positioning tube 30, when performing three-dimensional magnetic resonance scanning, inserts each positioning tube into a corresponding application tube in advance, so that the position of each application tube can be located in the three-dimensional magnetic resonance image.

In this embodiment, a three-dimensional magnetic resonance scan is performed by inserting a positioning tube into the outer tube of the applicator, and the three-dimensional magnetic resonance scan is performed in the three-dimensional magnetic resonance image, so that the outer tube of the applicator is in three-dimensional magnetic resonance. The image is no longer black, and can accurately display the position of the outer tube of the applicator and the structure and lesions of surrounding tissues according to the positioning device, providing better soft tissue contrast and better representing the tissue characteristics of the lesion. It can accurately locate the position of the outer tube of the applicator and provide a basis for accurately designing the radiotherapy plan, accurately controlling the location and time of the radioactive source, and improving treatment efficiency and safety.

FIG. 8 is a schematic flow chart of a method for locating a position based on magnetic resonance imaging according to another embodiment of the present application. As shown in FIG. 8, the method includes:

In step 201, the positioning tube is inserted into the outer tube of the applicator.

Specifically, there may be one or more sets of positioning tubes and outer tubes of the applicator, each set of positioning tubes and the outer tube of the applicator are matched with each other, and the outer tubes of different sizes of the applicators are provided with corresponding positioning tubes. Insert the positioning tube into the corresponding outer tube of the applicator, and several outer tubes of the applicator are inserted into several positioning tubes.

Wherein, the size of the positioning tube is matched with the outer tube of the applicator, and the positioning tube is a hollow tube filled with the imaging agent and the positioning device with high signal to noise ratio under magnetic resonance. Wherein, the imaging agent may be oil, water or other contrast enhancing agent (or imaging agent, contrast agent, etc.) suitable for magnetic resonance imaging, pre-closed in the positioning tube to ensure high in the three-dimensional magnetic resonance image Lights up the position of the application tube. The contrast enhancer is, for example, a complex of DTPA (钆-diethylenediaminepentaacetic acid) or the like.

Step 202, inserting the outer tube of the applicator inserted with the positioning tube into the application target site, and performing three-dimensional magnetic resonance imaging.

Specifically, before the treatment, the disinfected positioning tube is first inserted into the outer tube of the applicator, and then the disinfected external tube of the applicator and the positioning tube are inserted into the patient body for magnetic resonance three-dimensional imaging. The operator can estimate the position of the site to be administered based on experience or known information, and insert the outer tube of the applicator inserted with the positioning tube into the estimated target site.

Step 203, determining a source location according to the imaging agent and the positioning device in the positioning tube.

Three-dimensional magnetic resonance imaging is used to determine the position of the outer tube and the positioning tube of the applicator in the body, as well as the surrounding tissues and organs, to accurately assess the extent of the lesion and the relationship with the surrounding vital organs, on the basis of which individualized radiotherapy is developed. The plan further determines the deviation of the position of the outer tube of the current applicator from the actual application position, and adjusts the position of the outer tube of the applicator. In the three-dimensional magnetic resonance image, not only the tissue structure of the lesion and the surrounding organs can be clearly displayed, but also the imaging agent inside the positioning tube can be presented.

Wherein the positioning device comprises a depth positioning device and/or an angle positioning device, and determining the application position according to the imaging agent and the positioning device in the positioning tube comprises: determining the application position according to the angular positioning device The relative angle of the outer tube of the applicator, and/or determining the relative depth of the source of application and the outer tube of the applicator according to the depth positioning device. The angular positioning device is realized, for example, by providing small protrusions (longitudinal strips, etc.) on the inner wall of the positioning tube, and the small protrusions are also displayed in black in the magnetic resonance image, because the positioning tube is filled with the developer, so the image is It is easy to accurately find the small convexity of the angle positioning. In practice, in order to facilitate direct observation of the angle, more small convex structures can be designed to make the angular scale thinner. The feature of the cross-section of the depth positioning device varies with the cross-section at the positioning tube, for example, the area or width of each cross-section of the depth positioning device corresponds one-to-one with the depth of the cross-section in the positioning tube. Taking the depth positioning device as a conical shape as shown in FIG. 3, the depth position calculation method of one embodiment of the present application is as shown in FIG. 9. In the cross-sectional magnetic resonance image of the lesion portion, the width of the depth positioning device can be measured. d, D and H are known for a specific positioning tube, so the distance between the lesion and the tip of the positioning tube can be determined as h=H×d/D. In actual design, the depth positioning device can be reverse designed, and the principle is the same. ,No longer.

Step 204, taking out the positioning tube.

After the position of the outer tube of the applicator is adjusted, the application tube is fixed at a determined application position, and the positioning tube is taken out.

Step 205, determining the number and distribution structure of the required source channels according to the application position.

According to the specific situation of the application site, the radiation treatment plan can be precisely designed, such as the irradiation position of the radiation source, the irradiation angle, the irradiation dose, etc., and the number and distribution structure of the radiation source channels are determined according to the actual radiation source placement requirements.

Step 206: Select the inner tube of the applicator corresponding to the source channel of the quantity and distribution structure.

In order to meet different treatment needs, the structure of the inner tube of the applicator is various, such as: the number of radioactive source channels on the inner tube of the applicator is different, and the distribution positions of the channels are different.

Step 207: Fix the applicator inner tube in the applicator outer tube according to the application position.

In step 208, the source channel connected to the installed source is inserted into the corresponding inner tube of the applicator for radiation source irradiation.

The embodiment of the present application performs a three-dimensional magnetic resonance scan by inserting a positioning tube into the outer tube of the applicator and inserting the portion to be applied. Since the positioning tube can be highlighted in the three-dimensional magnetic resonance image, the outer tube of the applicator is in three dimensions. The magnetic resonance image is no longer black, which can clearly show the position of the outer tube of the applicator and the structure and lesions of the surrounding tissues and organs, provide better soft tissue contrast, and better represent the tissue characteristics of the lesion, so that it can be accurately Position the external tube of the applicator and provide a basis for accurately designing the radiotherapy plan, accurately controlling the location and time of the radioactive source, and improving treatment accuracy and safety.

It should be noted that in the description of the present application, the terms "first", "second" and the like are used for descriptive purposes only, and are not to be construed as indicating or implying relative importance. Further, in the description of the present application, the meaning of "a plurality" is two or more unless otherwise stated.

Any process or device description in the flowcharts or otherwise described herein can be understood as a module, segment or portion of code representing executable instructions including one or more steps for implementing a particular logical function or process. And the scope of preferred embodiments of the application includes Further implementations in which the functions may be performed in a substantially simultaneous manner or in an inverse order depending on the functions involved, which should be in accordance with the teachings of the embodiments of the present application. People understand.

It should be understood that portions of the application can be implemented in hardware, software, firmware, or a combination thereof. In the above-described embodiments, multiple steps or means may be implemented in software or firmware stored in a memory and executed by a suitable instruction execution system. For example, if implemented in hardware, as in another embodiment, it can be implemented by any one or combination of the following techniques well known in the art: having logic gates for implementing logic functions on data signals. Discrete logic circuits, application specific integrated circuits with suitable combinational logic gates, programmable gate arrays (PGAs), field programmable gate arrays (FPGAs), etc.

One of ordinary skill in the art can understand that all or part of the steps carried by the apparatus for implementing the above embodiments can be completed by a program to instruct related hardware, and the program can be stored in a computer readable storage medium. When performed, one or a combination of the steps of the device embodiments is included.

In the description of the present specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" and the like means a specific feature described in connection with the embodiment or example. A structure, material or feature is included in at least one embodiment or example of the application. In the present specification, the schematic representation of the above terms does not necessarily mean the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in a suitable manner in any one or more embodiments or examples.

While the embodiments of the present application have been shown and described above, it is understood that the above-described embodiments are illustrative and are not to be construed as limiting the scope of the present application. The embodiments are subject to variations, modifications, substitutions and variations.

Claims

A method for locating a position based on magnetic resonance imaging, characterized in that it comprises:

Insert the positioning tube into the outer tube of the applicator;

Inserting the outer tube of the applicator inserted with the positioning tube into the application target site, and performing three-dimensional magnetic resonance imaging;

The application position is determined based on the imaging agent and the positioning device in the positioning tube.
The method according to claim 1, wherein the positioning the outer tube of the applicator after the application of the source position further comprises:

Removing the positioning tube;

Fixing the applicator inner tube in the outer tube of the applicator according to the application position;

The source channel connected to the installed source is inserted into the corresponding inner tube of the applicator for radiation source irradiation.
The method according to any one of claims 1-2, wherein the positioning tube is sized to match the outer tube of the applicator, the positioning tube is a hollow tube, and the inside is filled with magnetic resonance The imaging agent of high signal to noise ratio.
The method according to claim 3, wherein the developer comprises oil or water, which is pre-blocked and filled in the positioning tube.
The method according to claim 1, wherein the positioning device comprises a depth positioning device and/or an angle positioning device, and the determining the application position according to the imaging agent and the positioning device in the positioning tube comprises:

Determining, according to the angular positioning device, a relative angle of the application position to the outer tube of the applicator, and/or,

Determining a relative depth of the application location from the outer tube of the applicator according to the depth positioning device.
The method of claim 5 wherein the area or width of the cross-section of the depth positioning device varies with the depth of the cross-section in the outer tube of the applicator, Determining the relative depth of the application location and the outer tube of the applicator includes:

Determining a distance of the application site to the outer nozzle of the applicator according to a cross section of the depth positioning device.
The method according to claim 5, further comprising: before the fixing the inner tube of the applicator in the outer tube of the applicator according to the application position, further comprising:

Determining the number and distribution structure of the required source channels according to the application position;

The inner tube of the applicator corresponding to the source channel of the quantity and distribution structure is selected.
A magnetic resonance imaging based applicator, comprising a post-installation machine, a radioactive source channel and an applicator outer tube, wherein the applicator further comprises a positioning tube matched with the outer tube of the applicator, wherein The positioning tube is hollow, and is internally filled with an imaging agent for magnetic resonance imaging and a positioning device for performing magnetic resonance imaging The image tube is built in the outer tube of the applicator, and the outer tube of the applicator is inserted into the application target site.
The applicator according to claim 8, wherein the imaging agent exhibits a high signal-to-noise ratio under magnetic resonance, and is enclosed and filled inside the positioning tube.
The applicator according to any one of claims 8 to 9, wherein the developer comprises oil or water.
The applicator of claim 8 further comprising an applicator inner tube that mates with the outer tube of the applicator, the applicator inner tube having one or more apertured channels therein, For placing one or more source channels, the arrangement of the hole channels is different.
The applicator according to claim 11, wherein the positioning tube, the outer tube of the applicator and the inner tube of the applicator are made of a magnetic resonance imaging compatible polymer material, and the surface is provided with a preset precision. Scale.
The applicator according to claim 11, wherein when the radiation therapy is performed, the inner tube of the applicator is fixedly coupled to the outer tube of the applicator, and the radiation is inserted through a hole-shaped passage in the inner tube. The source channel has one end connected to the post-installation machine and the other end being the lesion treatment end.
The applicator according to claim 8, wherein the positioning tube is provided with an angular positioning device and/or a depth positioning device.
The applicator according to claim 14, wherein said angular positioning means comprises a projection provided on an inner wall of said positioning tube.
The applicator according to claim 14, wherein said depth positioning means is disposed in said positioning tube, and a feature of a cross section of said depth positioning means varies with said cross section at said positioning tube .
The applicator according to claim 16, wherein the feature of the cross section comprises an area or a width of a cross section, and an area or a width of each cross section of the depth positioning device is opposite to the cross section The depth in the positioning tube is one-to-one correspondence.