WO2018028318A1

WO2018028318A1 - Weeding composition having synergistic effect

Info

Publication number: WO2018028318A1
Application number: PCT/CN2017/090018
Authority: WO
Inventors: 仲汉根; 季自华; 季红进; 花伟
Original assignee: 江苏辉丰农化股份有限公司
Priority date: 2016-08-08
Filing date: 2017-06-26
Publication date: 2018-02-15
Also published as: CN106259345A

Abstract

Provided is a weeding composition having a synergistic effect, said composition containing the active ingredients of diflufenican and butralin. The weight ratio of the active ingredient diflufenican to butralin may be 1：0.1~50. Pharmacodynamic tests have shown that the composition has positive features of having strong complementarity, evident synergistic effect, increased weed control spectrum, reduced application amount, prolonged appropriate application time, high crop safety, reduced environmental pollution, good environmental compatibility, and so on.

Description

Synergistic herbicidal composition

Technical field

The invention belongs to the field of agricultural plant protection, and in particular relates to a herbicidal composition with improved properties.

Background technique

The active ingredient diflufenican is a carotenoid biosynthesis inhibitor. Causes chlorophyll destruction and cell rupture, and plant death. Pilofenapamide is an amide herbicide that is applied before and after weed germination to form an anti-leaching soil layer on the soil surface and to maintain activity throughout the growing period of the crop. When weeds germinate through the shoots or roots of the soil, the penicillin can inhibit the carotenoid biosynthesis, and the content of carotenoids in the weed plants of the absorption agent decreases, causing the chlorophyll to be destroyed, and the cell membrane When the worm breaks, the weeds show that the young shoots are discolored or white, and finally the whole plant wilted and died.

The active ingredient sec-butyl is also known as butralin, which is a contact-killing and topical systemic bud-inhibiting agent. It is a low-toxic dinitroaniline tobacco bud inhibitor. It has high potency for inhibiting axillary bud growth and its efficacy. fast. It can be used without the rain within 2 hours after application. The pure product of bud bud is orange-yellow crystal, melting point 54 ° C ~ 58 ° C, soluble in chlorinated hydrocarbons and aromatic hydrocarbon solvents, stable under both alkaline and acidic conditions. Zhong Dingling is a herbicide for selective pre-emergence soil treatment. After entering the plant, the agent mainly inhibits the cell division of the meristem, thereby inhibiting the growth of weed shoots and young roots. It can also be used as a plant growth regulator to control the growth of tobacco axillary buds. Applicable to soybean, cotton, rice, corn, sunflower, potato, peanut, watermelon, sugar beet, sugar cane and vegetable crops, such as annual sedge weeds, goosegrass, crabgrass, foxtail, and other dicotyledonous weeds . It also has a good control effect on the soybean field.

Practical pesticide experience has shown that repeated and specific application of one active compound to control weeds will in many cases lead to rapid selectivity of weeds, and mixtures of different active compounds are currently commonly used to control harmful weeds. By combining active compounds having different mechanisms of action, resistance can be delayed, application rates can be reduced, and cost of control can be reduced.

Summary of the invention

The purpose of the invention is to screen the herbicide containing two different weeding principles for the resistance of the herbicide in practical application and the problem of soil residue, so as to improve the control effect of the herbicide, delay the generation of the resistance, and reduce the application amount. Reduce the cost of prevention.

Another object of the present invention is to provide an application of the above composition for controlling weeds in the agricultural field.

The object of the invention can be achieved by the following measures:

The present invention provides a synergistic herbicidal composition comprising active ingredients A and B, active ingredient A being diflufenic acid, and active ingredient B being sec-butyl.

The inventors found through experiments that the above herbicidal compositions have obvious synergistic effects, and more importantly, the application amount is reduced, and the use cost is lowered. The compounds containing component A and component B have different structural types and different mechanisms of action. The combination of the two can expand the herbicidal spectrum, and can delay the generation and development of weed resistance to some extent, and component A and There is no cross-resistance between component B.

The active ingredient of the composition of the present invention may contain only A and B, and may further contain other active ingredients without affecting the overall performance of the composition.

In one embodiment, the weight ratio of the active ingredient of the herbicidal composition of the present invention to pyridoxal and sec-butyl is from 1:0.1 to 50.

In another embodiment, the weight ratio of the active ingredient of the herbicidal composition of the present invention to pyridoxal and sec-butyl is from 1:1 to 50.

In another embodiment, the weight ratio of the active ingredient of the herbicidal composition of the present invention to pyridoxal and sec-butyl is from 1:1 to 40.

In a preferred embodiment, the weight ratio between the two components of A and B can be arbitrarily adjusted within the range of the following ratios: 1:0.1, 1:0.2, 1:0.3, 1:0.4, 1: 0.5, 1:0.6, 1:0.7, 1:0.8, 1:0.9, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 1:18, 1:19, 1:20, 1: 21, 1:22, 1:23, 1:24, 1:25, 1:26, 1:27, 1:28, 1:29, 1:30, 1:31, 1:32, 1:33, 1:34, 1:35, 1:36, 1:37, 1:38, 1:39, 1:40, 1:41, 1:42, 1:43, 1:44, 1:45, 1: 46, 1:47, 1:48, 1:49, 1:50, can also be selected within the range of any of the above two ratios, these ratios can be understood as the weight ratio, can also include the molar ratio.

The composition of the present invention can be formulated into a pesticide-acceptable dosage form together with an active ingredient and an agrochemical adjuvant.

The mass of the active ingredient in the composition of the present invention may be from 2 to 95%, preferably from 5 to 80%.

A carrier, an adjuvant and/or a surfactant may be included in the composition of the present invention. Common auxiliaries can be mixed during the application.

Suitable auxiliaries may be solid or liquid, they are usually materials commonly used in the processing of dosage forms, such as natural or regenerated minerals, solvents, dispersants, wetting agents, adhesives, thickeners, binders or fertilizers. .

The method of application of the composition of the invention comprises the use of the composition of the invention for aerial parts of plants, in particular leaves Department or leaf surface. The frequency of administration and the amount administered will depend on the biological and climatic conditions of the pathogen. The plant growth site, such as rice fields, may be wetted with a liquid formulation of the composition, or the composition may be applied to the soil in solid form, such as in the form of granules (soil application), the composition may be passed from the soil to the plant through the roots of the plant. In vivo (systemic action).

These compositions may be applied only by the active ingredient (also referred to as the active ingredient), or may be used in combination with an additive or an auxiliary agent, so that the composition of the present invention can be prepared into various dosage forms such as a wettable powder, a suspending agent, or the like. Dispersing oil suspending agents, water emulsions, emulsifiable concentrates, water-dispersible granules, and the like. Depending on the nature of the compositions and the intended purpose and environmental conditions to which the compositions are to be applied, the compositions may be applied by spraying, misting, dusting, spreading or pouring, and the like.

The composition of the present invention can be prepared into various dosage forms by a known method, for example, the active ingredient and an auxiliary agent such as a solvent, a solid carrier, and if necessary, can be uniformly mixed with a surfactant and ground to prepare a desired form. Formulation.

The above solvent may be selected from aromatic hydrocarbons, preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings. Alkenes or paraffins, alcohols and glycols and their ethers and esters, such as ethanol, ethylene glycol, ethylene glycol monomethyl; ketones, such as cyclohexanone, highly polar solvents such as N-methyl-2 Pyrrolidone, dimethyl sulfoxide or dimethylformamide, and vegetable or vegetable oils such as soybean oil.

The above solid carriers, such as those used in powders and dispersibles, are typically natural mineral fillers such as talc, kaolin, montmorillonite or activated clay. In order to manage the physical properties of the composition, it is also possible to add a highly dispersible silicic acid or a highly dispersible adsorbent polymer carrier, such as a particulate adsorbent carrier or a non-adsorbing carrier, and a suitable particulate adsorbent carrier is porous, such as pumice, bentonite or Bentonite; a suitable non-adsorbing carrier such as calcite or sand. In addition, a large amount of pre-granulated materials of inorganic or organic nature can be used as a carrier, in particular dolomite.

Suitable surfactants according to the chemical nature of the active ingredient in the composition of the present invention are lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, alkaline earth metal or amine salts, alkylarylsulfonates, alkyl groups Sulfates, alkyl sulfonates, fatty alcohol sulphates, fatty acids and sulfated fatty alcohol glycol ethers, as well as condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, naphthalene or naphthalene sulfonic acid with phenol and formaldehyde Condensate, polyoxyethylene octyl phenyl ether, ethoxylated isooctyl phenol, octyl phenol, nonyl phenol, alkyl aryl polyglycol ether, tributyl benzene polyglycol ether, three Stearyl phenyl polyglycol ether, alkyl aryl polyether alcohol, ethoxylated castor oil, polyoxyethylene alkyl ether, ethylene oxide condensate, ethoxylated polyoxypropylene, lauric acid poly Glycol ether acetal, sorbitol ester, lignin sulfite waste liquor and methyl cellulose.

The two active ingredients in the compositions of the present invention exhibit synergistic effects, the activity of which is more pronounced than the expected sum of activity using a single compound, and the individual activity of a single compound. The synergistic effect is manifested by allowing for a reduced application rate, a broader herbicidal control profile, quicker effect, longer lasting control effect, better control of weeds by only one or a few applications, and widening of possible application intervals . These characteristics are special in controlling weed practices needs.

The herbicidal composition of the present invention can be applied to the control of crop weeds in the agricultural field, in particular to control goosegrass, foxtail, valerian or crabgrass.

The other characteristics exhibited by the herbicidal composition of the present invention are mainly as follows: 1. Since the chemical composition of the two single agents of the present composition is very different, the mechanism of action is completely different, and there is no cross-resistance, and two single agents can be delayed. The resulting resistance problem is used alone; 2. The composition of the present invention is safe and effective against crops. It has been proved by experiments that the herbicide composition of the invention has stable chemical properties, remarkable synergistic effect, and exhibits obvious synergistic effect and complementary effect on the control object.

detailed description

In order to make the objects, technical solutions and advantages of the present invention more comprehensible, the present invention will be further described in detail below with reference to the embodiments. It is understood that the specific embodiments described herein are intended to be illustrative of the invention and are not to be construed as limiting the scope of the invention. Within the scope of protection of the present invention.

The percentages in all formulations in the following examples are percentages by weight. The processing techniques of the various formulations of the compositions of the present invention are all prior art and may vary depending on the circumstances.

First, the dosage form preparation example

(1) Processing and examples of wettable powders

The active ingredient flufenic acid is fully mixed with the active ingredient sec-butyl spirit, various auxiliaries and fillers, etc., and pulverized by an ultrafine pulverizer to obtain a wettable powder.

Example 1: 42% flufenacetin zhongdingling wettable powder

2% diflufenic acid, 40% sec-butyl, 4% bentonite, 5% sodium lignosulfonate, 4% formaldehyde sodium methoxide sulfonate, and kaolin up to 100%.

Example 2: 51% flufenacetin zhongdingling wettable powder

1% pyridoxamine, 50% sec-butyl, 4% potassium sulphate, 4% sodium benzene sulfonate, 4% bentonite, and 100% silica.

(2) Processing and examples of emulsifiable concentrate

The active ingredient pyripramine and zhongdingling, an emulsifier, an organic solvent and the like are uniformly mixed in a ratio of the formulation to obtain a finished product.

Example 3: 11% flufenacetate sec-butyl emulsifiable concentrate

10% piracetamide, 1% sec-butyl, 5% octylphenol, and 100% toluene.

Example 4: 5.5% flufenacetate sec-butyl emulsifiable concentrate

Pyrfluoxetamine 0.5%, sec-butyl 5%, tributyl phenyl polyglycol ether 4%, xylene up to 100%.

Example 5: 31% flufenacetate sec-butyl emulsifiable concentrate

1% diflufenic acid, 30% sec-butyl, 8% sorbitol, and 100% xylene.

(III) Processing and examples of water emulsion

The active ingredient pyripramine and zhongdingling, an emulsifier, a dispersing agent, an organic solvent, an antifreezing agent and the like are uniformly mixed in a ratio of the formulation to obtain a finished product.

Example 6: 20% flufenacetate sec-butyl spirit water emulsion

10% piracetamide, 10% sec-butyl, 8% methylcellulose, 4% polyvinyl alcohol, 5% ethylene glycol, 8% xylene, 0.2% glacial acetic acid, and 100% water.

Example 7: 41% flufenacetate sec-butyl spirit water emulsion

1% pyridoxamine, 40% sec-butyl, sodium methoxide sulfonate 5%, toluene 8%, cyclohexanone 10%, ammonium sulfate 5%, glacial acetic acid 0.5%, water to 100 %.

Second, the efficacy test

(1) Bioassay examples

Using flufenic acid as a standard agent, the disease index and control effect were calculated. The control effect is converted into the probability value (y), the concentration of the drug solution (μg/ml) is converted into the logarithm value (x), the virulence equation is calculated by the least squares method and the concentration EC50 is suppressed, and the virulence index of the drug is calculated according to the method of Sun Yunpei. Grade Co-toxicity coefficient (CTC). The virulence test results are shown in Table 1.

Measured virulence index (ATI) = (standard drug EC50 / test drug EC50) * 100

Theoretical virulence index (TTI) = A virulence index * Percentage of A in the mixture + B virulence index * Percentage of B in the mixture

Co-toxicity coefficient (CTC) = [mixture measured virulence index (ATI) / mixed theory virulence index (TTI)] * 100

CTC ≤ 80, the composition showed antagonism, 80 < CTC < 120, the composition showed an additive effect, CTC ≥ 120, and the composition showed synergistic effect.

1. The virulence test of penicillin and zhongdingling combined with rice barley

Table 1 Determination of virulence of different ratios of pyridoxamide and sec-butyl ping to rice sorghum (1)

The results (Table 1) showed that the ratio of flufenacetin to sec-butyl was between 1:0.1 and 50, and the co-toxicity coefficient was above 127, indicating that the combination of flufenacetin and sec-butyl ping was combined with rice sorghum. The control has a significant synergistic effect. It has been found that it is difficult to have a synergistic effect when the compounding ratio of flufenacetin to sec-butyl is not within the scope of the present invention.

2. The virulence test of diflufenic acid and zhongdingling paired with double-spotted gar. (2)

Table 2 Analysis of virulence determination results of diflufenic acid and zhongdingling complex

The results (Table 2) showed that the ratio of pyridoxal to sec-butyl was between 1:0.1 and 50, and the co-toxicity coefficient was above 130, indicating that the combination of flufenacet and zhongdingling The control of cockroaches has a significant synergistic effect. It has been found that it is difficult to have a synergistic effect when the compounding ratio of flufenacetin to sec-butyl is not within the scope of the present invention.

(2) Field efficacy test

1. The field control effect of flufenyl and sec-butyl is verified by the examples prepared by the present invention.

Expected control effect (%) = X + Y-XY / 100 (where X, Y is a single dose control)

Table 3. Field control trial results of pyriflufen and zhongdingling in combination with ragweed and red radish

The results of the determination (Table 3) showed that the control effect of flufenacet and zhongdingling on the control of ragweed and red radish was significantly improved, indicating that the combination of the two pairs of sage and red geranium was significant. Synergistic synergy.

Claims

A synergistic herbicidal composition characterized by comprising the active ingredients pyrfluoxal and sec-butyl.
The herbicidal composition according to claim 1, wherein the weight ratio of the active ingredient flufenic acid to sec-butyl is 1:0.1 to 50.
The herbicidal composition according to claim 2, wherein the weight ratio of the active ingredient of diflufenic acid to sec-butyl is from 1:1 to 50.
The herbicidal composition according to claim 3, wherein the weight ratio of the active ingredient of diflufenic acid to sec-butyl is from 1:1 to 40.
The herbicidal composition according to claim 1, wherein the composition is formulated into a pesticide-acceptable dosage form together with an active ingredient and an agrochemical adjuvant.
The herbicidal composition according to claim 5, wherein the active ingredient has a mass content of from 2 to 98%.
The herbicidal composition according to claim 6, wherein the active ingredient in the composition has a mass content of from 5 to 80%.
The herbicidal composition according to claim 5, characterized in that the dosage form is a wettable powder, an aqueous emulsion or an emulsifiable concentrate.
Use of the herbicidal composition of claim 1 for controlling crop weeds in the agricultural sector.
The use according to claim 9, characterized in that the weed is selected from the group consisting of goosegrass, foxtail, valerian or crabgrass.