CN106212465A - A kind of Herbicidal combinations comprising diflufenican and butralin - Google Patents

Abstract

The invention discloses a kind of Herbicidal combinations comprising diflufenican and butralin, said composition active component comprises diflufenican and butralin.Present invention also offers the purposes of said composition.Result of the test shows, the above-mentioned Herbicidal combinations potentiation that the present invention provides is obvious, and can reduce usage amount, reduces cost accounting.This Pesticidal combination can effective multiple weeds.By the herbicide agent of different mechanism of action and model of action being compounded, effectively reduce the amount of application of each single dose, general and delay the aspects such as Drug resistance to have well effect for expanding management of weeds.

Description

A kind of Herbicidal combinations comprising diflufenican and butralin

Technical field

The present invention relates to a kind of Herbicidal combinations having and improving performance, concretely relate to one and comprise pyrrole fluorine acyl grass Amine and the Herbicidal combinations of butralin, belong to pesticidal preparations and application.

Background technology

Using chemical herbicide is the maximally efficient means of the anti-a good appetite suddenly appearing in a serious disease of farmland weed.But make articles for use long-term continuous high dose Kind or the single chemical herbicide of model of action, easily cause the residual of herbicide, environmental pollution and weeds drug resistance and resistance The problems such as development.Rational chemical herbicide is compounding or mixture has expansion weeds spectrum, and raising preventive effect, prolongation dispenser are fitted Phase, minimizing dosage, reduction poisoning, minimizing remain, delay the features such as weeds drug resistance and drug-fast generation and development, are solutions Certainly one of maximally efficient method of the problems referred to above.Developing new product variety herbicide price constantly rises, and by contrast, exploitation height Effect, low toxicity, the compounding and mixture kind of low-residual have the advantages such as small investment, lead time is short, thus by domestic and international scientific research The attention of person.Go into overdrive to develop built agent and the mixed agent of herbicide one after another.

Active component diflufenican (diflufenican) this medicine belongs to herxheimer-liked reaction inhibitor.Cause Destruction of Chlorophyll and cell rupture, Plant death.Diflufenican is a kind of acetamide-group herbicides, and using before and after weeds germinate can Form the medicine soil layer of anti-leaching at soil table, keep activity at the whole trophophase of crop.When weed germination by medicine soil layer plumelet or Root system all can absorb medicament, and Diflufenican has suppression herxheimer-liked reaction effect, absorbs class in the weeds plant of medicament Carotene carotene content declines, and causes chlorophyll to be destroyed, membranolysis, and weeds then show as plumelet decolouring or white, the most whole Strain is wilted dead.

Butralin (Butralin) is the herbicide of soil treatment before selectivity bud, and its effect is similar to trefanocide, medicament After entering plant, the merismatic cell division of main suppression, thus suppress weeds plumelet and young root growth.Medicament is in weeds Germination growth is absorbed through during soil layer, mainly by suppressing merismatic cell division inhibition weeds plumelet and young root Growth, ultimately results in weeds dead.Can effectively prevent and kill off barnyard grass, Herba Eleusines Indicae, Herba Digitariae, Herba Setariae Viridis, Herba chenopodii, Herba Amaranthi tricoloris, Herba Portulacae etc. annual Grassy weed and small-sized seed broad leaved weed.Be applicable to Semen sojae atricolor, Cotton Gossypii, Semen arachidis hypogaeae, Citrullus vulgaris, Oryza sativa L., Rhizoma Solani tuber osi, Fructus Capsici, Fructus Lycopersici esculenti, Before the crop such as Fructus Solani melongenae, Chinese cabbage broadcasts rear Seedling or transplant before soil treatment.

Long-term repeat and single-minded use a kind of reactive compound and carry out management of weeds and will cause the anti-of weeds under many circumstances The property of medicine strengthens, and for reducing the evil herbicide property of medicine, the most generally uses the mixture of different activities compound to prevent and treat.By having The reactive compound having the different mechanism of action is combined, and delaying drug resistance can produce, reduces amount of application, improves prevention effect, and Reduce cost accounting.

Summary of the invention

It is an object of the invention to: for part pesticide resistance problem in actual applications, filter out two kinds not same-action former The pesticide of reason carries out compounding obtaining a kind of Herbicidal combinations, to improve prevention effect, reduces formulation rate.

For achieving the above object, the invention provides one group of composition pesticide, said composition comprises active component pyrrole fluorine acyl Grass amine and butralin.

Inventor is found by experiment that, above-mentioned composition pesticide potentiation is obvious, and amount of application reduces, it is possible to decrease use cost. The two kinds of active component compound structure types contained are different, and mechanism of action is different, and both are compounding can expand action spectrum, and Can the generation of delaying drug resistance to a certain extent, and no interactions resistance between component diflufenican and component butralin.

Present invention offer comprises diflufenican and the Herbicidal combinations of two kinds of effective ingredient of butralin and it is in agricultural The application of field preventing and treating crop weeds.

The compositions of the present invention comprises diflufenican and two kinds of active components of butralin, and the weight ratio between two components is 1:40～40:1, preferred weight ratio 1:30～30:1, for improving potentiation further, the weight ratio of two kinds of active components of A and B 1:20～20:1 can be optimized to further.

In some embodiments, two kinds of active component A and B can be selected for 40:1,39:1,38:1,37:1,36:1, 35:1、34:1、33:1、32:1、31:1、30:1、29:1、28:1、27:1、26:1、25:1、24:1、23:1、22:1、21:1、 20:1、19:1、18:1、17:1、16:1、15:1、14:1、13:1、12:1、11:1、10:1、9:1、8:1、7:1、6:1、5:1、4: 1、3:1、2:1、1:1、1:2、1:3、1:4、1:5、1:6、1:7、1:8、1:9、1:10、1:11、1:12、1:13、1:14、1:15、 1:16、1:17、1:18、1:19、1:20、1:21、1:22、1:23、1:24、1:25、1:26、1:27、1:28、1:29、1:30、1: 31, the more specifically proportioning such as 1:32,1:33,1:34,1:35,1:36,1:37,1:38,1:39,1:40, it is also possible to to take up an official post Two proportionings of anticipating select in the range of being formed.

Said composition can be aided with acceptable adjuvant on pesticide with active component and make any one of applicable agricultural use Kind of dosage form, concrete, it can be with active component and be aided with normally used auxiliary agent, solvent, carrier in pesticidal preparations and assist into Divide to make the various dosage form being suitable in agricultural and using.

When this compositions makes a certain concrete dosage form, wherein active component mass content be 3-90%, preferably 5～ 85%.

The compositions of the present invention can be prepared as various dosage form by available known method, can by effective ingredient with help Agent, such as solvent, solid carrier, uniformly can mix when needing together with surfactant or other components (such as solvent, carrier etc.) Close, grind, be prepared as required dosage form.

Suitably auxiliary agent can be solid or liquid, the material that they are conventional during being typically formulation, such as sky Mineral that is right or that regenerate, solvent, dispersant, wetting agent, adhesive, surfactant or fertilizer, a kind of selection can be selected, also Multiple selection can be selected.

Above-mentioned solvent is selected from aromatic hydrocarbon, preferably containing 8-12 carbon atom, such as xylene mixture or substituted benzene, phthalein Esters of gallic acid, such as Dibutyl phthalate or phthalandione two octanoic acid, fat hydrocarbon, such as thiacyclohexane or paraffin, alcohol and ethylene glycol and their ether And ester, such as ethanol, ethylene glycol, ethylene glycol monomethyl；Ketone, such as cyclohexanone, highly polar solvent, such as N-methyl-2-pyrrolidine Ketone, dimethyl sulfoxide or dimethylformamide, and vegetable oil or vegetable oil, such as soybean oil.

Above-mentioned carrier (particularly solid carrier), as powder and dispersible agent be typically natural mineral fillers, Such as Talcum, Kaolin, montmorillonite or active hargil.In order to manage the physical property of compositions, it is also possible to add polymolecularity Silicic acid or polymolecularity adsorpting polymerization thing carrier, such as granulated adsorptive carriers or non-adsorbed carrier, suitable granulated adsorptive carriers It is porous type, such as Pumex, Bentonite or bentonite；Suitably non-adsorbed carrier such as calcite or sand.Further, it is possible to use it is a large amount of Inorganic in nature or organic nature be prefabricated into granular material as carrier, particularly dolomite.

According to the chemical property of the effective ingredient in the compositions of the present invention, suitable surfactant is sulfomethylated lignin Acid, LOMAR PWA EINECS 246-676-2, phenolsulfonic acid, alkali salt or amine salt, alkylaryl sulfonates, alkyl sulfate, alkylsulfonate, fat Alcohol sulfate, fatty acid and sulphated fatty alcohol glycol ether, the also condensation substance of sulfonated naphthalene and naphthalene derivatives and formaldehyde, naphthalene or LOMAR PWA EINECS 246-676-2 and phenol and the condensation substance of formaldehyde, NONIN HS 240, ethoxylated isooctyl-phenol, octyl phenol, nonyl phenol, Alkylaryl polyglycol ether, tributyl benzene polyglycol ether, three stearyl phenyl polyglycol ethers, alkyl aryl polyether alcohol, Ethoxylated castor oil, polyoxyethylene alkyl ether, ethylene oxide condensation substance, ethoxylation polyoxypropylene, lauric acid Polyethylene Glycol Ether acetal, sorbitol ester, lignin sulfite waste liquor and methylcellulose.

The application process of the present composition includes the aerial parts that the compositions of the present invention is used for plant growing, including Leaf portion or blade face.The growth place of plant, such as rice field, can be soaked with the liquid preparation of compositions, or by compositions with Solid form is applied in soil, and as in granular form (soil application), compositions can be planted through plant root entrance by soil In object (systemic action).

These compositionss can only comprise active component and be administered, it is also possible to mix together with additive, because of The compositions of this present invention can be prepared as the current published various formulations of pesticide, such as wettable powder, water dispersible granules, Aqueous emulsion, microemulsion, cream, suspending agent, microcapsule formulations, dispersible oil-suspending agent etc..Character according to these compositionss And use compositions purpose to be reached and ambient conditions, can select compositions with spraying, atomizing, dust, broadcast sowing Or sprinkle the method watered or the like and use.

In the compositions of the present invention, two kinds of effective ingredient show as synergistic effect, than individualized compound independent activity more Significantly.Synergistic effect shows as allowing amount of application minimizing, broader weed control spectrum, instant effect, more longlasting prevention effect, only passing through Only once or minority is used several times and preferably controlled weeds and occur and broaden the possible administration interval time.These characteristics The resistance problem that generally there is solution herbicide single dose is very important.

The Pesticidal combination of the present invention apply Oryza sativa L., Semen Tritici aestivi, etc. on crops, prevent and kill off broad leaved weed, sedge weed, And part grassy weed, concrete such as grass, Herba monochoriae vaginalis or flat stalk grass etc..

Other feature that this product shows mainly shows themselves in that 1, can be applicable to soil spraying before stem and leaf spraying or Seedling；2, originally Two single dose chemical constitutions of compositions are widely different, and the mechanism of action is entirely different, there is not cross resistance, can delay two single doses It is used alone produced resistance problem；3, the compositions mixture of the present invention has obvious potentiation, to crop safety, prevents Imitate.Tests prove that, present composition stable chemical nature, potentiation is notable, and controlling object shows obvious potentiation And complementary action；4, obvious to the preventive effect of some malignant weed.

Detailed description of the invention

In order to make the purpose of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment, to the present invention It is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not used to limit Determining the present invention, all simple modifications under the concept thereof of the present invention to preparation method of the present invention broadly fall into the protection model of the present invention Within enclosing.

In all formula of following example, percentage ratio is all weight percentage.The processing work of the various preparation of the present composition Skill is prior art, can be varied from according to different situations.

One, dosage form prepares embodiment

(1) processing of water dispersible granules and embodiment

By active component diflufenican and butralin, mix homogeneously in the ratio of formula, through air-flow with auxiliary agent and filler It is ground into wettable powder, adds a certain amount of water mixing extruder grain, after drying screening, prepare water dispersible granules product.

Embodiment 1:85% diflufenican butralin water dispersible granules

Diflufenican 83%, butralin 2%, methyl naphthalene sulfonate formaldehyde condensate 5%, Negel 4%, ten Dialkyl group potassium sulfonate 2%, precipitated calcium carbonate complements to 100%.

Embodiment 2:85% diflufenican butralin water dispersible granules

Diflufenican potassium salt 2%, butralin 83%, alkyl polyoxyethanyl ether sulfonate 3%, sodium lignin sulfonate 3%, Sodium lauryl sulphate 2%, ammonium sulfate 2%, kieselguhr complements to 100%.

(2) processing of wettable powder and embodiment

Active component diflufenican is sufficiently mixed, through micropowder with various auxiliary agents and filler etc. in proportion with butralin Broken machine prepares wettable powder after pulverizing.

Embodiment 3:65% diflufenican Butralin wettable powder

Diflufenican 63%, butralin 2%, pulls open powder 5%, dodecylbenzene sodium sulfonate 4%, diatom 6%, attapulgite Soil complements to 100%.

Embodiment 4:65% diflufenican Butralin wettable powder

Diflufenican 2%, butralin 63%, calcium lignosulfonate 4%, alkyl polyoxyethanyl ether sulfonate 1%, swelling Soil 2%, white carbon 2%, kieselguhr complements to 100%.

Embodiment 5:45% diflufenican Butralin wettable powder

Diflufenican 43%, butralin 2%, sodium lignin sulfonate 5%, NONIN HS 240 3%, Kaolin 6%, kieselguhr complements to 100%.

Embodiment 6:45% diflufenican Butralin wettable powder

Diflufenican 2%, butralin 43%, sodium lignin sulfonate 4%, white carbon 3%, dodecylbenzene sodium sulfonate 5%, attapulgite complements to 100%.

(3) processing of microemulsion and embodiment

After active component diflufenican, butralin are completely dissolved in a solvent, it is stirred, is simultaneously introduced emulsifying Agent, builder and antifreeze, after above-mentioned system mixes, then be slowly added into water in above-mentioned mixed liquor, after being sufficiently stirred for i.e. The microemulsion of different content can be made into.

Embodiment 7:12% diflufenican butralin microemulsion

Diflufenican 10%, butralin 2%, carbamide 5%, Isopropanediol 3%, acetone 10%, compound sodium nitrophenolate 1%, alkane Base polyoxyethylene ether and NPE 2%, water complements to 100%.

Embodiment 8:12% diflufenican butralin microemulsion

Diflufenican 2%, butralin 10%, polyoxyethylene carboxylate and phenethyl phenol polyethenoxy ether 7%, azone 5%, glycerol 2%, methanol 6%, water complements to 100%.

(4) processing of aqueous emulsion and embodiment

In emulsifying kettle, active component diflufenican, butralin are mixed all under mechanical stirring with solvent, auxiliary agent Even, then put into emulsifying agent and stabilizer stirs, be eventually adding water, stir under the rotating speed of 100-12000 rev/min 10-30 minute, make the product of uniform emulsus.

Embodiment 9:22% diflufenican butralin aqueous emulsion

Diflufenican 20%, butralin 2%, polyvinyl alcohol 3%, sodium benzoate 4%, N-dimethyl phthalate 6%, nonyl phenol benzene oxygen vinyl Ether 5%, 2,6-di-tert-butyl-4-methy phenols 5%, ethylene glycol 3%, organic silicon defoamer 0.8%, water complements to 100%.

Embodiment 10:12% diflufenican butralin aqueous emulsion

Diflufenican 2%, butralin 20%, propylene glycol 4%, xanthan gum 3%, polyvinyl alcohol 2%, butylhydroxy Fructus Foeniculi Ether 2%, poly-isosuccinic acid acid anhydride-ethylene glycol copolymer 5%, organic silicon defoamer 1.2%, water complements to 100%.

(5) processing and the embodiment of oil-suspending agent are dispersibled

Surfactant is mixed with oil base etc. and to be sufficiently mixed in proportion, under degree of doing shear agitation, add active component pyrrole The fluorine acyl different monooctyl ester of grass amine, butralin, grind in sand mill, grinds until a range of particle diameter.

Embodiment 11:15% diflufenican butralin dispersibles oil-suspending agent

Diflufenican 10%, butralin 5%, calcium lignosulfonate 7%, xanthan gum 2%, mineral oil complements to 100%.

Embodiment 12:15% diflufenican butralin dispersibles oil-suspending agent

Diflufenican 5%, butralin 10%, N-dimethyl phthalate 6%, alkyl polyoxyethanyl ether sulfonate 4%, soybean oil complements to 100%.

Embodiment 13:20% diflufenican butralin dispersibles oil-suspending agent

Diflufenican 10%, butralin 10%, Butylated hydroxyanisole 4%, methyl oleate 6%, poly-isosuccinic acid acid anhydride- Ethylene glycol copolymer 3%, soybean oil complements to 100%.

Two, drug effect checking test

(1) indoor virulence determination of activity

Embodiment 1 diflufenican is compounding with butralin to grass determination test

(1) Assays Example 1

Using diflufenican as standard agent, calculate disease index and prevention effect.Prevention effect is converted into probability Value (y), liquor strength (μ g/ml) is converted into logarithm value (x), calculates concentration in virulence equation and suppression with method of least square EC50, calculates toxicity index level co-toxicity coefficient (CTC) of medicament according to the abundant method of Sun Yun.Toxicity test the results are shown in Table 1.

Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agent EC50) * 100

Percentage composition+B medicament toxicity index * the mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture The percentage composition of middle B

Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theory toxicity index (TTI)] * 100

CTC≤80, compositions shows as antagonism, 80 ＜ CTC ＜ 120, and compositions shows as summation action, CTC >= 120, compositions shows as potentiation.

1, diflufenican toxicity test test to rice terrace grass compounding with butralin

The toxicity test analysis (one) to grass compounding with butralin different ratio of table 1 diflufenican

Result (table 1) shows, diflufenican prevention effect to grass compounding with butralin significantly improves, and the two is described Compounding have significant potentiation to grass.Experiment find, the proportioning of two kinds of effective ingredient not when above-mentioned scope to grass Prevent and kill off without synergism.

Table 2 diflufenican is compounding with butralin to be tested Herba monochoriae vaginalis toxicity test

Result (table 2) shows, diflufenican prevention effect to rice terrace Herba monochoriae vaginalis compounding with butralin significantly improves, Illustrating the two to compound Herba monochoriae vaginalis has significant potentiation.Experiment finds, the proportioning of two kinds of effective ingredient is not in above-mentioned scope Time Herba monochoriae vaginalis is prevented and kill off without synergism.

(2) field control effectiveness test

1, utilize the embodiment that the present invention prepares to verify the field control effect of diflufenican and butralin.

Expection preventive effect (%)=X+Y-XY/100 (wherein, X, Y are single dose preventive effect)

Table 3. diflufenican field efficiency test result to flat stalk grass compounding with butralin

As can be seen from the above table, diflufenican is compounding with butralin has good prevention effect to flat stalk grass, says Bright have significant synergistic function between the two.

Claims (10)

1. the Herbicidal combinations comprising diflufenican and butralin, it is characterised in that said composition comprises active component pyrrole Fluorine acyl grass amine and butralin.

The Herbicidal combinations comprising diflufenican and butralin the most according to claim 1, it is characterised in that effectively group Dividing the weight ratio between diflufenican and butralin is 1～40:40～1.

The Herbicidal combinations comprising diflufenican and butralin the most according to claim 2, it is characterised in that effectively group Dividing the weight ratio between diflufenican and butralin is 1～30:30～1.

The Herbicidal combinations comprising diflufenican and butralin the most according to claim 3, it is characterised in that effectively group Dividing the weight ratio between diflufenican and butralin is 1～20:20～1.

The Herbicidal combinations comprising diflufenican and butralin the most according to claim 1, it is characterised in that this combination Thing is aided with acceptable adjuvant on pesticide by active component and jointly makes acceptable dosage form on pesticide.

The Herbicidal combinations comprising diflufenican and butralin the most according to claim 5, it is characterised in that this combination In thing, the mass content of active component diflufenican and butralin is 3～90%.

The Herbicidal combinations comprising diflufenican and butralin the most according to claim 6, it is characterised in that this combination In thing, the mass content of active component diflufenican and butralin is 5～85%.

The Herbicidal combinations comprising diflufenican and butralin the most according to claim 5, it is characterised in that described dose Type is wettable powder, water dispersible granules, aqueous emulsion, dispersibles oil-suspending agent or suspending agent.

9. in claim 1～8 Herbicidal combinations comprising diflufenican and butralin described in any one in agricultural The purposes of crop weeds is prevented and kill off in field.

Purposes the most according to claim 9, it is characterised in that described weeds are selected from grass, Herba monochoriae vaginalis or flat stalk grass.