WO2017209554A3 - 항-nrp1 항체 스크리닝 방법 - Google Patents

항-nrp1 항체 스크리닝 방법 Download PDF

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Publication number
WO2017209554A3
WO2017209554A3 PCT/KR2017/005767 KR2017005767W WO2017209554A3 WO 2017209554 A3 WO2017209554 A3 WO 2017209554A3 KR 2017005767 W KR2017005767 W KR 2017005767W WO 2017209554 A3 WO2017209554 A3 WO 2017209554A3
Authority
WO
WIPO (PCT)
Prior art keywords
nrp1
screening method
antibody screening
nrp1 antibody
antigen
Prior art date
Application number
PCT/KR2017/005767
Other languages
English (en)
French (fr)
Other versions
WO2017209554A2 (ko
Inventor
남도현
이재현
Original Assignee
사회복지법인 삼성생명공익재단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 사회복지법인 삼성생명공익재단 filed Critical 사회복지법인 삼성생명공익재단
Priority to US16/306,568 priority Critical patent/US11085930B2/en
Priority to JP2018562956A priority patent/JP6837499B2/ja
Priority to SG11201810775SA priority patent/SG11201810775SA/en
Priority to CA3026238A priority patent/CA3026238C/en
Priority to EP17807047.0A priority patent/EP3467508A4/en
Priority to AU2017273170A priority patent/AU2017273170B2/en
Priority to CN201780041972.7A priority patent/CN109416363A/zh
Priority claimed from KR1020170069141A external-priority patent/KR101993893B1/ko
Publication of WO2017209554A2 publication Critical patent/WO2017209554A2/ko
Publication of WO2017209554A3 publication Critical patent/WO2017209554A3/ko

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  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

본 발명은 NRP1 과발현 환자 유래 세포 및 이를 포함하는 동물모델을 이용하여 항-NRP1 항체 또는 이의 항원 결합 단편을 스크리닝하는 방법에 관한 것으로 보다 구체적으로는, NRP1을 함유하는 환자 유래 세포 및 이를 이식한 동물모델을 각각 이용한 in vitro 및 in vivo 패닝을 통해 항체 또는 이의 항원 결합 단편을 스크리닝하는 방법에 관한 것이다.
PCT/KR2017/005767 2016-06-03 2017-06-02 항-nrp1 항체 스크리닝 방법 WO2017209554A2 (ko)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US16/306,568 US11085930B2 (en) 2016-06-03 2017-06-02 Anti-NRP1 antibody screening method
JP2018562956A JP6837499B2 (ja) 2016-06-03 2017-06-02 抗−ｎｒｐ１抗体スクリーニング方法
SG11201810775SA SG11201810775SA (en) 2016-06-03 2017-06-02 Anti-nrp1 antibody screening method
CA3026238A CA3026238C (en) 2016-06-03 2017-06-02 Anti-nrp1 antibody screening method
EP17807047.0A EP3467508A4 (en) 2016-06-03 2017-06-02 ANTI-NRP1 ANTIBODY SCREENING METHOD
AU2017273170A AU2017273170B2 (en) 2016-06-03 2017-06-02 Anti-NRP1 antibody screening method
CN201780041972.7A CN109416363A (zh) 2016-06-03 2017-06-02 抗nrp1抗体筛选方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20160069360 2016-06-03
KR10-2016-0069360 2016-06-03
KR1020170069141A KR101993893B1 (ko) 2016-06-03 2017-06-02 항-nrp1 항체 스크리닝 방법
KR10-2017-0069141 2017-06-02

Publications (2)

Publication Number Publication Date
WO2017209554A2 WO2017209554A2 (ko) 2017-12-07
WO2017209554A3 true WO2017209554A3 (ko) 2018-01-18

Family

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PCT/KR2017/005767 WO2017209554A2 (ko) 2016-06-03 2017-06-02 항-nrp1 항체 스크리닝 방법

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WO (1) WO2017209554A2 (ko)

Citations (4)

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US20020199212A1 (en) * 2001-05-10 2002-12-26 Saburo Sone Non-human animal exhibiting bone metastasis of tumor cells and method of screening for bone metastasis inhibitors
KR20080068105A (ko) * 2005-11-08 2008-07-22 제넨테크, 인크. 뉴로필린 길항제
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KR20150105615A (ko) * 2014-03-07 2015-09-17 사회복지법인 삼성생명공익재단 ScFv 항체 라이브러리, 이의 제조방법 및 이를 이용한 ScFv 항체 스크리닝 방법

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ATE87659T1 (de) 1986-09-02 1993-04-15 Enzon Lab Inc Bindungsmolekuele mit einzelpolypeptidkette.
DE3852304T3 (de) 1987-03-02 1999-07-01 Enzon Lab Inc Organismus als Träger für "Single Chain Antibody Domain (SCAD)".
DE3852074D1 (de) 1987-03-20 1994-12-15 Creative Biomolecules Inc Verfahren zur reinigung von rekombinanten polypeptiden.
JP2535066B2 (ja) 1987-03-20 1996-09-18 クリエイティブ・バイオマリキュールズ・インコーポレーテッド 組換え体タンパク質製造のためのリ―ダ―配列
JPH02500329A (ja) 1987-05-21 1990-02-08 クリエイテイブ・バイオマリキユールズ・インコーポレーテツド ターゲット化多機能蛋白質
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Patent Citations (4)

* Cited by examiner, † Cited by third party
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US20020199212A1 (en) * 2001-05-10 2002-12-26 Saburo Sone Non-human animal exhibiting bone metastasis of tumor cells and method of screening for bone metastasis inhibitors
KR20080068105A (ko) * 2005-11-08 2008-07-22 제넨테크, 인크. 뉴로필린 길항제
KR20120048563A (ko) * 2009-06-22 2012-05-15 번햄 인스티튜트 포 메디칼 리서치 Ｃ?말단 요소를 가진 펩타이드 및 단백질의 사용방법 및 그 조성물
KR20150105615A (ko) * 2014-03-07 2015-09-17 사회복지법인 삼성생명공익재단 ScFv 항체 라이브러리, 이의 제조방법 및 이를 이용한 ScFv 항체 스크리닝 방법

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
See also references of EP3467508A4 *
WILLIAMS ET AL.: "Identification of an Antibody Fragment Specific for Androgen-dependent Prostate Cancer Celis", BMC BIOTECHNOLOGY, vol. 14, 3 September 2014 (2014-09-03), pages 1 - 11, XP021195833 *
WILLIAMS ET AL.: "In Vitro Selection of Cancer Cell -specific Molecular Recognition Elements from Amino Acid Libraries", JOURNAL OF IMMUNOLOGY RESEARCH, vol. 2015, 7 September 2015 (2015-09-07), pages 1 - 12, XP055556675 *

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