WO2017204474A1 - Appareil portable d'analyse de liquide organique de type indépendant - Google Patents

Appareil portable d'analyse de liquide organique de type indépendant Download PDF

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Publication number
WO2017204474A1
WO2017204474A1 PCT/KR2017/004599 KR2017004599W WO2017204474A1 WO 2017204474 A1 WO2017204474 A1 WO 2017204474A1 KR 2017004599 W KR2017004599 W KR 2017004599W WO 2017204474 A1 WO2017204474 A1 WO 2017204474A1
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WO
WIPO (PCT)
Prior art keywords
body fluid
unit
image
sample
light
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PCT/KR2017/004599
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English (en)
Korean (ko)
Inventor
김지훈
Original Assignee
(주)종로의료기
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Publication of WO2017204474A1 publication Critical patent/WO2017204474A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48785—Electrical and electronic details of measuring devices for physical analysis of liquid biological material not specific to a particular test method, e.g. user interface or power supply
    • G01N33/48792—Data management, e.g. communication with processing unit
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/1717—Systems in which incident light is modified in accordance with the properties of the material investigated with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N2021/1765—Method using an image detector and processing of image signal
    • G01N2021/177—Detector of the video camera type

Definitions

  • the present invention relates to a portable body fluid testing apparatus, and more particularly, to a portable body fluid testing apparatus that can be conveniently connected to various portable terminals through short-range communication and can be conveniently used.
  • the tester uses secretions discharged from the body, for example, saliva, urine, sweat, and the like, and a method of detecting hormones contained in the secretions or checking a state such as a change in secretions is used.
  • the tester utilizes a change in the state of a component contained in saliva when the body has a specific condition, for example, a disease, an infection, or an abnormality or specificity of the body such as a ovulator.
  • testers for pregnancy diagnosis, diabetes diagnosis, and blood sugar checking are widely used in various forms. In particular, testers are frequently used by users because they are relatively high in accuracy, easy to use, and can be used anytime the user wants to use them at a low price.
  • the pregnancy tester has recently been used by the infertility and infertile couples who are increasing due to the increase of marriage age, the increase of stress from social life, the lack of exercise.
  • the existing pregnancy diagnosis tester can not only determine whether or not pregnant, it does not help to increase the probability of pregnancy of users suffering from infertility and infertility.
  • the existing tester can only confirm whether pregnancy has occurred, and important matters such as the possibility of pregnancy of a woman, the arrival of the ovulatory period and the fertility of a male cannot be confirmed through the tester, but only by the medical institution. There is a limit.
  • an object of the present invention is to provide a portable body fluid testing apparatus that provides a portable and easy-to-use tester so that a user can directly perform a test anytime and anywhere using his body fluid and check the analysis result. will be.
  • Another object of the present invention is that both women and men can be used for each test purpose so that women can check their ovulatory period to determine the high probability of pregnancy, and men to check their sperm status
  • women and men can be used for each test purpose so that women can check their ovulatory period to determine the high probability of pregnancy, and men to check their sperm status
  • another object of the present invention is to provide a portable body fluid testing apparatus that can be easily connected to a variety of portable terminals through short-range communication and can be conveniently used, easy and sanitary use.
  • the independent portable bodily fluid testing apparatus includes a unit unit for inserting or discharging a sample unit, and a unit unit for enlarging and photographing the bodily fluid applied to the sample unit, and a communication module for communication with the outside. And a user terminal for establishing a communication channel with the test unit, receiving a photographed image obtained by photographing the bodily fluid from the test unit, and analyzing the bodily fluid image to determine a state of the bodily fluid. It is characterized in that the configuration.
  • An illumination unit disposed in the space to supply light to the sample unit inserted into the case;
  • a lens group having one side disposed to face one surface of the sample part;
  • a camera disposed on the other side of the lens group to capture an image of the sample part;
  • a power supply unit supplying power to the camera and the lighting unit;
  • a memory in which an image photographed by the camera is stored;
  • a control unit controlling the operation of the camera and on / off of power;
  • a communication module for forming a communication channel with the user terminal under the control of the controller, and for transmitting the bodily fluid image to the user terminal.
  • the sample unit is inserted between the illumination unit and the lens group.
  • the case may be formed of a non-transparent material that prevents the transmission of light, or may be painted with a material that prevents the transmission of light.
  • the light source provided in the lighting unit is characterized in that it emits a monochromatic light.
  • the interior of the case is characterized in that the mounting portion for guiding and supporting the sample portion is inserted into the insertion hole is formed.
  • the sample portion is characterized in that it is formed of any one of a light-transmissive synthetic resin, natural rubber and glass.
  • the sample portion may be formed of a light transmissive material, and may be formed of a material that is colored in a single color or transmits light having a predetermined wavelength.
  • the sample portion is characterized in that the portion to which the body fluid is applied is formed concave.
  • the body fluid image photographed by the test unit is a crystal formed by the drying of the body fluid; Cells contained in the body fluids; And at least one image of a specific substance included in the body fluid.
  • the humoral image is characterized in that it comprises an image of any one of sperm, vaginal mucosa cells, oral cells, bacteria and cells infected with bacteria contained in the body fluid.
  • the portable body fluid testing apparatus can provide a tester which is portable and easy to use, so that a user can directly perform a test at any time and anywhere using his body fluid and check the analysis result.
  • Portable body fluid testing apparatus to enable both women and men can be used for each test purpose to check the ovulatory period of the female to determine the high probability of pregnancy, the male can check their sperm state It is possible to increase your chances of getting pregnant.
  • the portable body fluid testing apparatus can be conveniently connected to various portable terminals through short-range communication, and can be used conveniently and sanitarily.
  • FIG. 1 is an exemplary view showing an example of use of the stand-alone portable test device according to the present invention.
  • Figure 2 is an exemplary view showing in more detail the sample unit and the test unit body of the test unit.
  • Figure 3 is an exemplary view showing in detail the internal configuration of the test unit.
  • FIG. 4 is an exemplary view showing in more detail the configuration of the circuit portion and the main portion.
  • FIG. 5 is an exemplary diagram for explaining a change in body fluid for pattern analysis.
  • FIG. 6 is an exemplary view showing a test image using real body fluids.
  • FIG. 7 is an exemplary diagram showing an example of a partition pattern used for analysis of a test image.
  • FIG 8 is an exemplary view showing an example where the body fluid is semen or vaginal discharge.
  • FIG. 1 is an exemplary view showing an example of the use of the stand-alone portable test device according to the present invention
  • Figure 2 is an exemplary view showing a sample unit of the test unit and the test unit body in more detail
  • Figure 3 is an exemplary diagram showing the internal configuration of the test unit in detail
  • Figure 4 is an exemplary diagram showing the configuration of the circuit portion and the main portion in more detail.
  • another stand-alone portable testing device includes a test unit 10 and a user terminal 100.
  • the test unit 10 plays a role of capturing and delivering an image of the body fluid so that the image analysis of the body fluid can be performed by the user terminal 100 using the user's body fluid as a sample. More specifically, the test unit 10 is configured to include a sample unit 20, the body of the user is applied to the sample unit 20 is coupled to the test unit 10. When the test unit 10 is coupled to the sample unit 20 to which the body fluid is applied, the test unit 10 enlarges the sample unit 20 by the camera 100 provided therein, creates a body fluid image, and creates the image of the user terminal. To pass on. Thereafter, the user terminal 100 analyzes the bodily fluid image by the analysis program and outputs the analyzed result to the user or delivers the result to a specialized examination institution. The detailed configuration of the test unit 10 and the analysis method by the user terminal 100 will be described in more detail with reference to other drawings below.
  • the test unit 10 enlarges and captures the body fluid of the sample unit 20 to which the body fluid is applied, and transmits the body fluid image data generated by the imaging to the user terminal 100. Therefore, the test unit 10 includes a power supply unit 30, an illumination unit 50, a memory unit 60, a communication unit, a control unit 80 and a camera 110 as shown in FIG. The components may be built in one case 11 as shown in FIG. 3.
  • the case 11 accommodates and fixes a configuration for executing a function of the test unit 10 therein, and serves to protect these configurations from external impact or contamination.
  • the case 11 may be configured to include an inner case 13 for separating and partitioning the configuration internally and stably photographing the image of the body fluid applied to the sample unit 20, thereby limiting the present invention. It is not.
  • the inner case 13 serves to separate the circuit unit 40 and the unit unit 15, and provides a dark room to the camera 110, the lighting unit 50, and the sample unit 20 of the unit unit 15.
  • the camera 110 and the lens group 35 and the sample unit 20 play a role of maintaining a constant distance, that is, a focal length, so that a clear and accurate image can be taken.
  • the case 11 may include an insertion hole 12 for inserting or extracting the sample part 20 to which the body fluid is applied, and a seating part 34 inside the case 11 near the insertion hole 12. ) Is formed, and serves to enable the sample portion 20 to be inserted and fixed at the correct position.
  • the case 11 may be made of a material that is resistant to external impacts such as synthetic resin and metal, and may be made of a light material, but the present invention is not limited to the present invention by suggesting that the case 11 may be formed using tempered glass or wood.
  • the case 11 may be formed with a lid for replacing the power supply unit 30 and the interface 31 to which a cable for connecting data to the external power supply for charging or transmitting data stored in the memory 60 is connected. .
  • the sample unit 20 is coated with a body fluid to be tested, and serves as a stage for the camera 110 of the test unit 10 to photograph the body fluid.
  • the sample part 20 is composed of a sheet 21 to which the body fluid is applied and a base 23 serving as a handle.
  • the sheet 21 is formed by concave recessed surface of the base 23, the body fluid is applied to the recessed surface, and thereby serves to uniformly apply a certain amount of body fluid to the sheet 21.
  • the sample part 20 is formed in the form of a thin plate as shown, and is formed of a transparent material, for example, a synthetic resin such as polycarbonate, polyethylene, acrylic, glass, or the like for obtaining light and clear images. Can be.
  • the image of the body fluid may be colored in a single color or the film may be attached to one surface, but this does not limit the present invention.
  • the power supply unit 30 supplies power for the operation of the test unit.
  • the power supply unit 30 may be configured using a replaceable and lightweight disposable battery or a rechargeable battery capable of charging or discharging, or may be directly connected to an external power supply by a terminal formed in the case 11 to receive power. Can be configured.
  • the case 11 may include an interface terminal connected to an external power source, and may be connected to a user terminal, a portable battery, and a charger through the interface terminal.
  • the lighting unit 50 generates light by the light source 52 by the power transmitted from the power supply unit 30, and transmits the generated light to the sample unit 20 to confirm an image of the body fluid applied to the sample unit 20. Or to be photographed.
  • the light source unit 10 is disposed at a position parallel to the camera 110 with the sample unit 20 therebetween so that light generated from the light source 52 passes through the sample unit 20 to the camera 110.
  • the lighting unit 50 may include a light source 52 and a light source circuit 51 for controlling the points of the light source 52, and the light source circuit 51 may be configured together on the circuit board 40. Can be.
  • the light source 52 of the illumination unit 50 is composed of a monochromatic light source that emits monochromatic light such as green, blue, and red, so that the image of the object to be photographed, such as a substance in the body fluid or a crystal generated by the body fluid, can be made clear.
  • the light source 52 may be a multi-color light source or a light source that emits white light.
  • the film 54 which causes the sample unit 20 to pass or only a wavelength of a specific light passes through the light source ( 52) and can be placed between the sample unit 20.
  • the position of the light source 52 may be adjusted using a light path changing means such as a mirror and a light guiding means. It is possible to change, or to change the position of the camera 110, which is not intended to limit the present invention as presented.
  • the memory 60 receives and stores the bodily fluid image photographed by the camera 110 from the controller 80, and stores a program for the operation of the test unit 10.
  • the memory 60 may be a fixed memory fixed to the circuit board 40, but may be a memory configured to be inserted into or discharged from the test unit 10, such as an SD card, and an interface terminal 31 in addition to the internal memory. It may be an external memory connected through).
  • the communication unit forms a communication channel with an external device, for example, the user terminal 100, and transmits a bodily fluid image through the formed communication channel.
  • the communication unit serves to transfer the bodily fluid image stored in the memory 60 or captured by the camera 110 through a communication channel.
  • the communication unit may form a wired or wireless communication channel of various methods such as USB, infrared, Wi-Fi, and Bluetooth with the user terminal 100, and a plurality of communication modules may be configured.
  • the communication unit may transmit a call for establishing a communication channel to the user terminal 100, and may receive a call from the user terminal 100 to form a communication channel. It does not limit the invention.
  • the controller 80 controls the respective components of the test unit 10 to photograph the body fluid image applied to the sample unit 20, and controls each unit to transfer the captured body fluid image to the user terminal 100. .
  • the controller 80 receives an operation command from the user terminal 100 formed by a switch or a communication channel provided outside the case 11, and allows the camera 110 to capture an image of the sample unit 20.
  • the bodily fluid image transmitted from the camera 110 is stored in the memory 60, and when the user terminal 100 requests or resumes the communication channel, the stored bodily fluid image is transmitted to the communication unit to be transmitted to the user terminal 100. do.
  • the controller 80 controls the operation of the communication unit to form a communication channel with the user terminal 100.
  • the controller 80 may mediate the transfer of data, ie, a bodily fluid image, between the camera 110 and the communication unit so that the image is transmitted to the user terminal 100 in real time, but the present invention is not limited thereto.
  • the camera 110 operates by receiving power from the power supply unit 30 under the control of the control unit 80, photographs the body fluid image of the sample unit 20, and transfers the data generated by the photographing to the control unit 80. .
  • control unit 80, the communication unit, the memory 60, the power supply unit 30, and also the illumination unit may be configured in a space configured by dedicating a predetermined space inside the case 11, as shown in FIG. It may be interconnected by means mounted on or equivalent thereto. That is, the configuration shown in Figures 1 to 4 is only presented as an example, various modifications are possible for miniaturization and light weight, and modifications of this category are included in the scope of the present invention.
  • the user terminal 100 is connected to the test unit 10 by a communication channel and receives a bodily fluid image from the test unit 10, and analyzes the received bodily fluid image to provide an analysis result to the user.
  • the user terminal 100 may form a communication channel with the test unit 10 by a wired or wireless communication channel, and any type of terminal may be used as long as it is a terminal capable of analyzing a bodily fluid image by installing a program (or application). Do.
  • the user terminal 100 may be a device such as a user's mobile phone, a smart pad, a notebook, but the present invention is not limited thereto.
  • FIGS. 5 to 7 are exemplary diagrams for explaining the pattern analysis method according to the present invention
  • Figure 5 is an exemplary diagram for explaining the change of the body fluid for pattern analysis
  • Figure 6 shows a test image using the actual body fluid It is an illustration
  • 7 is an exemplary diagram illustrating an example of a partition pattern used for analysis of a test image.
  • body fluids in particular saliva (or saliva) can be used as an indicator for various symptoms.
  • saliva or saliva
  • saliva saliva
  • saliva of women of childbearing age clearly shows special signs.
  • accurate ovulation can be predicted by the effect of estrogen, a female hormone contained in the saliva of women, through which the couple suffering from infertility can increase the likelihood of pregnancy.
  • the female saliva during the transition to the fertile phase during ovulation in the non-fertile phase is slightly crystallized in the form as shown in (b) of FIG. 5, and the crystalline form at this time is electrolyte, mucus, enzyme, etc. It has the form of circular, long-shaped salivary cells (shape) formed.
  • the bodily fluid state determination system of the present invention analyzes the state of the saliva to determine whether the user is of childbearing age, and prepares the identified information as analysis information and provides the user.
  • the user terminal 100 processes the photographed test image to clarify the crystal lines, and determines whether the crystal lines form a closed curve or whether the ferns have a leaf-shaped straight line as shown in (c). In particular, the length density of the linear pattern is confirmed.
  • non-fertile, transitional and fertile phases are determined and provided to the user as analysis information.
  • the image processing and the non-fertile, transition, and discrimination of the fertile phase can be adjusted according to the density and shape of the pattern, so the detailed description thereof will be omitted.
  • the image is reprocessed in black and white, and the contrast of the black and white processing can be determined, and the linear determination and the length and density can be determined through this. Since various methods can be used, a detailed description thereof will be omitted. do.
  • partition patterns may be used as shown in FIG. 7 to increase the accuracy of such image processing and determination. That is, it is possible to prepare the analysis information by checking how many straight or elliptical lines exist in the region (inner region of the closed line) defined by the pattern.
  • such a partition pattern may be provided in a form printed on the lens group 35 or the sample unit 20 of the user terminal 100, and a part of the analysis image is divided into partition patterns by the user terminal 100. It is also possible to carry out an imaging process, and the present invention is not limited only to what is shown.
  • Figure 8 is an exemplary view showing an example when the body fluid is semen or vaginal discharge.
  • the preparation of such analytical information can also be performed for semen in men.
  • the semen of the male is discriminated using the state discrimination system of the present invention, the number of sperm, the activity of the sperm, and whether the sperm is deformed can be checked. In particular, the sperm state is improved and the pregnancy is attempted. It is possible to do that.
  • the segmentation pattern can also be used in the analysis of semen, which is illustrated in FIGS. 8A and 8B.
  • Sperm characteristics can be easily analyzed by determining the number, activity, and shape of sperm located in the lattice pattern formed in the center of (a) and (b). More specifically, the user terminal 100 or a medical institution system (not shown) analyzes the sperm distributed throughout the captured image, and performs sampling analysis on the sperm in the area partitioned by the partition pattern. can do. Through this, the present invention can be quickly analyzed, it is possible to reduce the pattern processing load of the user terminal 100, it is possible to perform the analysis in more detail.
  • partition patterns are illustrated in FIGS. 7 and 8 in a lattice form, but may be formed in various shapes such as ellipses and circles, and may specify arbitrary positions as well as the center of the screen.
  • the analysis can be performed by applying the partition pattern to a high density to check the image, and the present invention is not limited to the present invention.
  • the user terminal 100 captures the semen applied to the sample unit 20 to secure a test image.
  • the user terminal 100 calculates the number of sperm identified in a predetermined region in the test image, a moving distance of a specific sperm, an average of moving distances, rotational speed, rotation speed, and rotation radius.
  • the user terminal 100 may photograph and use a plurality of test images, or confirm by photographing in a video form.
  • the sperm state can be confirmed by randomly selecting a specific sperm in the image and determining the sperm characteristics of the selected sperm. In addition, by selecting a plurality of such sampling sperm, it is possible to increase the accuracy of sperm characterization.
  • the user terminal 100 selects some sperm from the test image, processes the image of the selected sperm into a clear pattern or a black and white image, and compares the sperm with a pre-stored image or a form meeting a predetermined condition. It is also possible to determine whether there is a malformation. For example, the number of tails (tails) per hull (round part), the bending of the tail, and the shape of the hull can be determined to determine whether the sperm in the test image has a normal shape.
  • a partition pattern is applied as shown in FIG. 9, and sperm characteristics are targeted to sperm located in a region defined by the partition pattern among sperm in the test image. Can be analyzed.
  • vaginal discharge as in (c) it can be determined whether there is a disease such as bacterial vaginosis, vaginitis, and whether there is a medical examination.
  • a disease such as bacterial vaginosis, vaginitis, and whether there is a medical examination.
  • vaginal discharge is observed using a test apparatus, only vaginal mucosal cells are observed in normal cases, but when a disease caused by bacterial infection occurs as shown in (c) of FIG. The substances can be identified.
  • the secretion of antimicrobial substances in the vagina increased and the vaginal acidity increased and the anaerobic bacteria were overproliferated. It will be covered, and it will be possible to check these symptoms by means of a test device.
  • the present invention it is possible to determine various states such as the presence or absence of a disease, a disease name, and ovulation phase by enlarging and photographing body secretions such as saliva, vaginal secretions, and semen in men.
  • the portable body fluid testing apparatus provides a portable tester which is portable and easy to use, so that the user can directly perform a test anytime and anywhere within a short time using his own body fluid, and confirm the analysis result. It can be used as an auxiliary device, and the service can be provided through this.

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Abstract

La présente invention concerne un appareil portable d'analyse de liquide organique facile à connecter à divers terminaux portables par communication en champ proche de manière à être utilisé de manière pratique, et pouvant être utilisé facilement et de manière hygiénique. L'appareil portable d'analyse de liquide organique de type indépendant selon la présente invention comprend : une partie formant unité pour permettre à une partie d'échantillon d'être insérée ou déchargée, et pour photographier par agrandissement un liquide organique à l'échantillon ; une unité d'analyse dans laquelle un module de communication permettant de communiquer avec l'extérieur est disposé dans une partie de circuit ; et un terminal utilisateur permettant de former un canal de communication avec l'unité d'analyse, recevoir, en provenance de l'unité d'analyse, une image photographiée, obtenue en photographiant le liquide organique et en analysant l'image du liquide organique afin de déterminer l'état du liquide organique.
PCT/KR2017/004599 2016-05-26 2017-04-28 Appareil portable d'analyse de liquide organique de type indépendant WO2017204474A1 (fr)

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KR1020160065125A KR20170133833A (ko) 2016-05-26 2016-05-26 독립형 휴대용 체액 검사장치
KR10-2016-0065125 2016-05-26

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CN109946299A (zh) * 2019-04-01 2019-06-28 谢跃兵 一种便携式居家体液检测装置

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CN114786575A (zh) * 2019-12-02 2022-07-22 因途因有限公司 体液观察仪器
WO2021112357A1 (fr) * 2019-12-02 2021-06-10 주식회사 인트인 Dispositif d'observation de liquide organique

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CN109946299A (zh) * 2019-04-01 2019-06-28 谢跃兵 一种便携式居家体液检测装置
CN109946299B (zh) * 2019-04-01 2023-08-25 谢跃兵 一种便携式居家体液检测装置

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