WO2018097585A1 - Unité d'échantillon pour dispositif d'essai de fluide corporel, et dispositif d'essai de fluide corporel comprenant celle-ci - Google Patents

Unité d'échantillon pour dispositif d'essai de fluide corporel, et dispositif d'essai de fluide corporel comprenant celle-ci Download PDF

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Publication number
WO2018097585A1
WO2018097585A1 PCT/KR2017/013317 KR2017013317W WO2018097585A1 WO 2018097585 A1 WO2018097585 A1 WO 2018097585A1 KR 2017013317 W KR2017013317 W KR 2017013317W WO 2018097585 A1 WO2018097585 A1 WO 2018097585A1
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WO
WIPO (PCT)
Prior art keywords
body fluid
sample
base
sheet
opsovo
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PCT/KR2017/013317
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English (en)
Korean (ko)
Inventor
김지훈
Original Assignee
(주)종로의료기
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Publication date
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Publication of WO2018097585A1 publication Critical patent/WO2018097585A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48785—Electrical and electronic details of measuring devices for physical analysis of liquid biological material not specific to a particular test method, e.g. user interface or power supply
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Definitions

  • the present invention relates to a body fluid testing apparatus, and more particularly, to a sample part having a member for adjusting the amount of a sample so that an optimal sample for a test is collected and a tester device having the same.
  • Such a tester uses secretions discharged from the body, for example, saliva, urine, sweat, secretions, such as detecting a hormone contained in the secretions, or a method for identifying such matters as changes in the state of the secretion is used.
  • Such a tester utilizes a change in a state of a component contained in a saliva when a body has a specific condition, for example, a disease, an infection, or an abnormality or specificity of a body such as a ovulator. Therefore, testers are relatively high in accuracy and easy to use, and they are frequently used because users can use them at any time at a low price, and typical testers are widely used to perform tests such as pregnancy diagnosis, diabetes diagnosis, and blood glucose measurement. have.
  • such testers use body fluid as a sample and measure the state change of the sample, or measure and analyze the components to confirm and express the user's condition.
  • general test equipments have sampling means for collecting the sample liquid. Users apply body fluids to these sampling means for testing, and the tester analyzes the state of the body fluids applied to the sampling means to calculate the results of the test.
  • testers have become electronic devices, so that various items can be tested as compared with the related art.
  • another object of the present invention is to cause a chemical reaction according to the state of the body fluid in the member for the amount adjustment to determine the user's body state more accurately and in detail through the user's naked eye discrimination and recognition by the tester It is to provide a sample unit and a tester device having the same.
  • Another object of the present invention is to ensure that the pre-tested testers to automatically recognize the mounting of the appropriate sample portion to prevent misuse, and to operate the tester by the sample portion, thereby improving the convenience of use of the sample It is to provide a tester apparatus having a part and the same.
  • the sample part according to the present invention is coated with a body fluid, and in the sample part detachably attached to a test apparatus for inspecting the body fluid, a predetermined portion of the first surface is formed to be concave than the first surface, so that the body fluid A base forming the sheet to be contained therein; And an opsovo formed in a ring shape in which a hole is formed and coupled to the first surface of the edge of the sheet so that the sheet is exposed by the hole.
  • the opsovo is characterized in that the absorbent absorbs liquid.
  • the surface of the opsovo is characterized in that the non-transmissive film is attached to prevent the penetration of the liquid.
  • the non-transmissive film is attached to the surface of the opsovo so that the side surface formed with the hole that is the inner periphery of the opsovo is exposed.
  • the opsovo is characterized in that it contains an indicator that reacts with the body fluid and gives a predetermined visibility result.
  • the opsovo is characterized in that it contains a plurality of indicators that react with different components of the body fluid.
  • the base on which the sheet is formed is formed of a material through which light is transmitted.
  • the base is characterized in that it is colored in a predetermined monochromatic color.
  • the sample portion is characterized in that the conductive pattern formed with the electrode terminal on the base is formed.
  • the conductive pattern may be formed on any one side of the base, a second surface opposite to the first surface of the base, and a portion of the first surface other than the sheet forming position.
  • the inspection apparatus includes a sample portion having a base is formed to be concave than the first surface so that the body fluid is contained, and the opsovo coupled to the first surface of the base to expose the sheet; An enlarged lens group into which the sample part is inserted or discharged, and for enlarging the body fluid applied to the sample part; A camera for capturing an image of the body fluid enlarged by the magnifying lens group; A light source unit supplying light for photographing the sample unit; And a controller configured to analyze the image of the body fluid and generate an analysis result.
  • the opsovo is formed in a ring shape in which a hole is formed, and is coupled to the edge of the sheet of the base to expose the sheet by the hole, and is formed of an absorbent absorbing liquid.
  • the surface of the observer is characterized in that the non-transmissive film is attached to prevent the permeation of liquid.
  • the non-transmissive film is attached to the surface of the opsovo so that the side surface formed with the hole that is the inner periphery of the opsovo is exposed.
  • the opsovo is characterized in that it contains an indicator that reacts with the body fluid and displays a predetermined visibility result.
  • the opsovo is characterized in that it contains a plurality of indicators that react with different components of the body fluid.
  • the camera may generate an image by photographing the opsovo reacting with the body fluid, and the controller may analyze the state of the body fluid by comparing the visibility result of the opsovo with a previously stored image.
  • the base may be formed of a light transmissive material through which light is transmitted.
  • the base is characterized in that it is colored in a predetermined monochromatic color.
  • It is characterized in that it further comprises a switching circuit for detecting the insertion or discharge of the sample unit to supply an operation signal or switch to supply power to operate at least one of the camera, the light source unit and the control unit.
  • the sample portion is characterized in that the conductive pattern formed with the electrode terminal on the base is formed.
  • the conductive pattern may be formed on any one side of the base, a second surface opposite to the first surface of the base, and a portion of the first surface other than the sheet forming position.
  • a seating part for supporting or fixing the sample part is formed when the sample part is inserted, and the seating part is electrically contacted with the conductive pattern when the sample part is inserted, and a contact part for electrically connecting the conductive pattern and the switching circuit is provided. It is characterized by being formed.
  • the sample unit and the tester device having the same according to the present invention can adjust the amount of the sample so that the optimum sample is collected for the test, thereby enabling accurate testing and preventing the test apparatus from being contaminated.
  • sample unit and the tester device having the same allows the chemical reaction according to the state of the body fluid to occur in the member for adjusting the amount of the sample to determine the physical state of the user through the user's naked eye discrimination and recognition by the tester It is possible to make it more accurate and detailed.
  • sample part and the tester apparatus having the same according to the present invention can automatically recognize the mounting of the appropriate sample part to prevent misuse and improve the convenience of use by allowing the tester to operate by the sample part. .
  • FIG. 1 is a perspective view showing an example of a sample unit according to the first embodiment of the present invention.
  • FIG. 2 is an exploded perspective view of FIG.
  • FIG 3 is an exemplary view showing a perspective view of a sample unit according to a second embodiment of the present invention.
  • FIG. 4 is a cross-sectional view illustrating the cross section of FIG. 3.
  • FIG. 5 is a perspective view showing an example of an inspection apparatus in which a sample unit according to the first embodiment of the present invention is used.
  • FIG. 6 is an exemplary configuration diagram illustrating an internal configuration of FIG. 5.
  • FIG. 7 is an exemplary block diagram showing the configuration of a test apparatus in a block form
  • FIG. 8 is an exemplary diagram for explaining a change in body fluid for pattern analysis.
  • 9 is an exemplary view showing a test image using a real body fluid.
  • FIG. 10 is an exemplary diagram showing an example of a partition pattern used for analysis of a test image.
  • Figure 11 is an illustration showing an example where the body fluid is semen or vaginal discharge.
  • FIG. 12 is an exemplary view showing a configuration of a sample unit according to a third embodiment of the present invention.
  • FIG. 13 is an exemplary view showing another example of a test apparatus according to the present invention.
  • FIG. 1 is a perspective view showing an example of a sample part according to the first embodiment of the present invention
  • Figure 2 is an exploded perspective view of FIG.
  • the sample unit 20 according to the first embodiment of the present invention includes a base 23 and an observer assembly 30, and the observer assembly 30 is an obsovo. 36 and the film 31 are comprised.
  • the sample unit 20 is coated with the body fluid to be tested, and serves as a stage for the camera of the test apparatus (described below with reference to other drawings) to capture the body fluid.
  • the sample portion 20 is composed of a sheet 21 to which the body fluid is applied and a base 23 serving as a handle.
  • the sheet 21 may be integrally formed with the base 23, and may be formed by concave a part of the base 23 surface, or may be formed by forming a protruding wall around the area to which the sheet 21 is to be formed. Can be.
  • the sheet 21 formed recessed relative to the surface of the base 23 has a flat contact surface to which the sample is in contact so that a certain amount of the sample is applied and the sample is evenly distributed on the entire surface of the sheet 21.
  • the body fluid may be applied to the sheet 21 and analyzed by the inspection apparatus as it is in a liquid state, or analyzed by the inspection apparatus in a naturally dried state after application. This will be described in detail with reference to the other drawings below.
  • the base 23 is formed in the form of a thin plate, as shown, and is formed of a transparent material, for example, a transparent synthetic resin such as polycarbonate, polyethylene, acrylic, glass, or the like for light transmission and clear image strokes. Can be.
  • a transparent synthetic resin such as polycarbonate, polyethylene, acrylic, glass, or the like for light transmission and clear image strokes. Can be.
  • the sheet 21 forming part may be concave to form an integral part, but the sheet 21 and the base 23 may be manufactured and combined, respectively.
  • the sheet 21 and the base 23 may be formed of different materials.
  • it is also possible to form the sample part by forming the base 23 with the absorber 36 described below, and forming only the sheet 21 from transparent synthetic resin or glass and joining.
  • the part of the sheet 21 may be colored in a single color or a single color film may be attached to one surface so as to sharpen the bodily fluid image, but the present invention is not limited thereto.
  • the observer assembly 30 is coupled to the surface on which the body fluid of the base 23 is applied to adjust the amount of body fluid applied to the sheet 21.
  • the absorber assembly 30 may use a test paper expressed in a predetermined form in response to the components of the body fluid applied to the sheet 21.
  • the absorber assembly 30 may include the observer 36 and the film 31.
  • the obsaver 36 may have a ring shape in which a hole 33 corresponding to the sheet 21 is formed at the center thereof.
  • the opsovo 36 is coupled on the base 23 to surround the sheet 21 to absorb the over-coated body fluid of the body fluid applied to the sheet 21 to receive a certain amount of body fluid in the sheet 21. Play a role.
  • the opsovo 36 may be formed of a material capable of absorbing liquid, for example, cotton, paper, or a porous synthetic resin, but the present invention is not limited only to the materials presented.
  • the opsovo 36 may be provided with a test substance that reacts with a specific component of the body fluid, so that the application of the body fluid reacts with the specific component of the body fluid and makes a specific indication.
  • the opsovo 36 may be discolored by the body fluid to check the acidity of the body fluid.
  • the opsovo 36 may include indicators for measuring various concentrations or states such as PH, potential, metal ions, and hydrogen ions of the body fluid, and a combination indicator capable of detecting two or more states may be included in the opsovo 36. ) May be applied.
  • the film 31 may be attached to the other surface of the opsovo 36, that is, the surface parallel to the surface on which the opsovo 36 and the base 23 are coupled.
  • the film 31 is used to prevent the body of the user from contacting the part other than the sheet 23 when the body fluid is applied, or to prevent the body fluid applied to the sheet 21 from being applied directly to the opsovo 36 ( 36) is attached or combined.
  • the film 31 is formed of a material such as non-hygroscopic, non-permeable synthetic resin, rubber, and is coupled to the opsovo 36 to surround the upper surface or outer periphery of the opsovo 36.
  • the film 31 exposes the side surface 34 of the portion of the hole 33 of the opsovo 36, that is, the inner circumferential portion of the film 31 to expose the body fluid exceeding a certain amount of the body fluid applied to the sheet 21. It serves to absorb water through.
  • FIG. 3 and 4 are views showing an example of a sample unit according to a second embodiment of the present invention
  • Figure 3 is an exemplary view showing a perspective view of the sample unit according to a second embodiment of the present invention
  • Figure 4 It is an example of a cross section which shows the cross section of 3.
  • the sample unit 120 includes a base 123 and an observer assembly 130.
  • the sample part 120 according to the second embodiment differs only in the shape of the base 123 compared to the first embodiment described above, and other structural features are similar to those of the sample part 20 in the first embodiment. Therefore, in the description of the second embodiment, detailed descriptions of components similar or identical to those of the above-described embodiment will be omitted, and description will be made based on differences.
  • the base 123 is formed in a cylindrical shape unlike the first embodiment described above.
  • One end of the base 123 is used as the seat 121, and the other end thereof faces the camera of the inspection apparatus.
  • one side end is recessed into the base 123, as shown in the cross-sectional view, and is formed concave, wherein the bottom may be formed flat.
  • the side of the base 123 may be formed with a stepped portion 124 for coupling with the inspection device, but this does not limit the present invention, the formation and form of the stepped portion 124 to the inspection device This is determined by.
  • the observer assembly 130 is coupled to the edge of the sheet 121 at one end of the base 123.
  • the observer assembly 130 comprises a film coupled to the opsovo 136 and the opsovo 136 as in the first embodiment described above.
  • the sample unit 120 of the second embodiment is used by being coupled to the inspection apparatus in one end and the other end direction.
  • FIG. 5 is a perspective view showing an example of an inspection apparatus in which a sample unit according to the first embodiment of the present invention is used
  • FIG. 6 is a diagram illustrating the internal configuration of FIG. 5.
  • 7 is an exemplary block diagram showing the configuration of the inspection apparatus in a block form.
  • the inspection apparatus 10 serves to determine the user's state by using the user's body fluid as a sample.
  • the inspection apparatus 10 may be a device that is configured alone as shown to photograph and analyze body fluid and provide a result thereof to an external device, or output and provide the same through an external device.
  • the device may be a device for delivering a captured image of a body fluid to an external device connected to the test device 10 and analyzing the same by an external device and providing the same to a user.
  • description will be made mainly on an example of a device in which the inspection device 10 photographs and analyzes body fluids and transmits the results thereof to an external device.
  • this does not limit the invention, and various modifications are possible except as indicated, which is within the scope of the present invention.
  • the test device 10 is configured to include a sample unit 20, the body of the user is applied to the sample unit 20 is coupled to the test device 10.
  • the inspection apparatus 10 is coupled to the sample unit 20 coated with the body fluid
  • the sample unit 20 is enlarged by the camera 110 provided therein, thereby generating a body fluid image, and analyzing the generated image.
  • the result of the analysis is delivered to an external device connected by a communication channel.
  • the external device may be a computer system of a company providing a professional medical service such as a mobile terminal or a stationary computer such as a mobile terminal such as a user's smartphone, a smart pad, a notebook computer, a hospital, etc. It is not.
  • the gastric apparatus performs a more precise analysis using the delivered analysis result and the bodily fluid image, or outputs the analysis result and provides it to a user or a medical institution.
  • the inspection apparatus 10 magnifies and captures the body fluid of the sample unit 20 to which the body fluid is applied, and prepares the body fluid image data generated by the imaging.
  • the inspection apparatus 10 includes a power supply unit 90, an illumination unit 50, a memory 60, a communication unit, a control unit 80, and a camera 110.
  • the configuration such as the communication unit, the controller 80, and the memory 60 may be integrated in one circuit board 16.
  • the case 11 accommodates and fixes a configuration for executing the function of the inspection apparatus 10 therein, and serves to protect these components from external impact or contamination.
  • the case 11 separates and partitions the structure internally, and stably captures an image of the body fluid applied to the sheet 21, and prevents the inspection apparatus 10 from being contaminated by the body fluid.
  • It may be configured to include an inner case 13 to be detachably and fixed to the (21).
  • the case 11 may be provided with an insertion hole 12 for inserting or extracting the sample portion 20 to which the body fluid is applied, and the seating portion 44 inside the case 11 near the insertion hole 12. ) Is formed, and serves to enable the sample unit 20 to be fixed at the correct position.
  • the case 11 may be made of a material that is resistant to external impacts such as synthetic resin and metal, and may be made of a light material, but may be formed using tempered glass or wood, and the present invention is not limited only to the present invention.
  • the case 11 may be formed with a lid for replacing the power supply unit 90 and the interface 31 to which the cable for the transmission of data stored in the memory 60 or the power supply device for charging.
  • the power supply unit 90 supplies power for the operation of the test apparatus 10.
  • the power supply unit 90 is configured using a replaceable, lightweight disposable battery or a rechargeable battery capable of charging or discharging, or configured to be directly connected to an external power supply by a terminal formed in the case 11 to receive power.
  • the case 11 may include an interface terminal connected to an external power source, and may be connected to a user terminal, a portable battery, a charger, and a power supply device through the interface terminal.
  • the lighting unit 50 generates light by the light source 52 by the power transmitted from the power supply unit 90, and transmits the generated light to the sample unit 20 to confirm an image of the body fluids directed to the sample unit 20. Or to be photographed.
  • the light source unit 10 is disposed at a position parallel to the camera 110 with the sample unit 20 therebetween so that light generated from the light source 52 passes through the sample unit 20 to the camera 110.
  • the lighting unit 50 may include a light source 52 and a light source circuit 51 for controlling the lighting of the light source 52, and the light source circuit 51 may be configured together on the circuit board 16. Can be.
  • the light source 52 of the illumination unit 50 is composed of a monochromatic light source that emits monochromatic light such as green, blue, and red, so that the image of the object to be photographed, such as a substance in the body fluid or a crystal generated by the body fluid, can be made clear.
  • a monochromatic light source that emits monochromatic light such as green, blue, and red
  • the sample unit 20 is colored as described above, or the colored film 54 that transmits a specific monochromatic light is the light source 52 and the sample unit 20. ) In between.
  • the light source 52, the sample unit 20, and the camera 110 may be configured to be located in a straight line as shown in the figure, the light source 52 or the camera 110, such as a mirror, light guide means The position can be changed by using the light path changing means.
  • the memory 60 receives and stores the bodily fluid image captured by the camera 110 and the analysis result of analyzing the bodily fluid image from the controller 80, and may store analysis software for analysis.
  • the memory 60 may be a fixed memory fixed to the circuit board 40, but may be a removable memory such as an SD card and a USB memory.
  • the communication unit forms a communication channel with an external device and transmits a bodily fluid image or an analysis result through the communication channel.
  • a communication unit may be configured using wired or wireless communication means of various methods such as USB, infrared, Wi-Fi, Bluetooth.
  • the controller 80 controls the respective components of the inspection apparatus 10 to capture an image of the bodily fluid applied to the sample unit 20, and analyzes the bodily fluid image generated by the photographing to analyze the state of the user. To this end, the controller 80 analyzes a bodily fluid image using software stored in the memory 60. In particular, when the analysis result is prepared, the controller 80 transmits the analysis result or the bodily fluid image to the external device through a communication channel formed between the external device and the external device.
  • the opsovo 30 includes the knowledge medicine for distinguishing the pH or acidic acid group
  • the opsovo 30 is photographed and compared with the previously stored color control table to calculate the acidity / basicity and acidity of the user's body fluid. It is possible to do
  • FIG. 7 is an exemplary view for explaining an example of an inspection apparatus used by the sample unit according to the second embodiment of the present invention.
  • the inspection apparatus includes an enlarged lens for enlarging the body fluid applied to the sheet part 120 on which the sheet 121 is formed, and the sheet 121 of the sheet part 120.
  • a guide having a group, and one side of the magnifying lens group is disposed to face the second surface 125 of the sheet 121, and the guide 144 is in close contact with photographing means for capturing an image of the enlarged body fluid through the magnifying lens group.
  • a light source unit 210 for supplying light to the sheet 121.
  • the inspection apparatus 100 is attached to a user terminal having a camera, and the user terminal acquires an image of a body fluid through the camera, and analyzes the acquired image by a program installed in the terminal. Used as
  • the light source unit 210 transmits external light or light generated by the light source to the sheet unit 120, and serves as a light source for capturing an image of the body fluid applied to the sheet unit 120.
  • the light source unit 210 is formed in a cylindrical shape in which the inside of the body 211 of the light source unit 210 is empty so that light can be transmitted to the lower surface of the sheet 121, which is the second surface 125 of the sheet unit 120.
  • One end of the light source unit 210 is fitted to the seating portion 122 formed on the side surface of the sheet second surface 125 of the sheet portion 20 to be coupled to the sheet portion 20.
  • the light source unit 210 uses a light source, a light source, a circuit for driving the light source, a switch, and a power supply unit for the operation of the light source may be configured in the light source unit 210.
  • the light source unit 210 may be formed of a transparent material, or a hole into which the external light flows may be formed in the light source unit 210.
  • the light source provided in the light source unit may be a light source for outputting monochromatic light, and an optical film for converting external light or white light into monochromatic light may be configured in the light source unit, but the present invention is not limited thereto. .
  • the border unit 140 connects the sheet unit 120 and the test terminal, and serves to allow the test terminal (not shown) to take an image of the body fluid applied to the sheet unit 120.
  • the border portion 140 is coupled to the sheet portion 120 such that the objective portion 141 faces the second surface 9125 of the sheet portion 120.
  • the border portion 140 is also formed in the form of a hollow pipe, and an enlarged lens group (not shown) is configured to provide an enlarged image of the sheet portion 120 therein.
  • the position of the magnifying lens group 145 is changed by adjusting the length of the rich body 142 of the abutment unit 140, thereby allowing magnification and focus adjustment to be made, and through this, an inspection terminal having a different magnification is provided.
  • the guide 144 is formed at the other end of the border portion 140.
  • the guide 144 serves to prevent the magnifying lens group from directly contacting the inspection terminal and to maintain the constant distance between the inspection terminal and the magnifying lens group 35 so that accurate magnification adjustment can be made.
  • FIGS. 8 to 10 are exemplary diagrams for explaining a pattern analysis method according to the present invention
  • FIG. 8 is an exemplary diagram for explaining a change in body fluid for pattern analysis
  • FIG. 9 is a test image using actual body fluid. It is an illustration.
  • 10 is an exemplary diagram illustrating an example of a partition pattern used for analyzing a test image.
  • saliva in the case of body fluids, in particular saliva (or saliva) can be used as an indicator for various symptoms.
  • saliva or saliva
  • saliva of women of childbearing age clearly shows special signs. Specifically, accurate ovulation can be predicted by the effect of estrogen, a female hormone contained in the saliva of women, through which the couple suffering from infertility can increase the likelihood of pregnancy.
  • the female saliva during the transition to the fertile phase during ovulation in the non-fertile phase is slightly crystallized in the form as shown in (b) of FIG. 5, and the crystalline form at this time is electrolyte, mucus, enzyme, etc. It has the form of circular, long-shaped salivary cells (shape) formed.
  • the bodily fluid state determination system of the present invention analyzes the state of the saliva to determine whether the user is of childbearing age, and prepares the identified information as analysis information and provides the user.
  • the length density of the pattern is checked.
  • non-fertile, transitional and fertile phases are determined and provided to the user as analysis information.
  • the image processing and the non-fertile, transition, and discrimination of the fertile phase can be adjusted according to the density and shape of the pattern, so the detailed description thereof will be omitted.
  • the image is reprocessed in black and white, and the contrast of the black and white processing can be determined, and the linear determination and the length and density can be determined through this. Since various methods can be used, a detailed description thereof will be omitted. do.
  • partition patterns may be used as shown in FIG. 10 to increase the accuracy of such image processing and determination. That is, it is possible to prepare the analysis information by checking how many straight or elliptical lines exist in the region (inner region of the closed line) defined by the pattern.
  • the partition pattern may be provided in a form printed on the lens group 145 or the sample unit 120 of the inspection apparatus, and the inspection apparatus may classify a portion of the analysis image into partition patterns and perform imaging processing.
  • the present invention is not limited only to what is shown.
  • Figure 11 is an exemplary view showing an example when the body fluid is semen or vaginal discharge.
  • the preparation of such analytical information can also be performed for semen in men.
  • the semen of the male is discriminated using the state discrimination system of the present invention, the number of sperm, the activity of the sperm, and whether the sperm is deformed can be confirmed. It is possible to do that.
  • the segmentation pattern can also be used in the analysis of semen, which is illustrated in FIGS. 11A and 11B.
  • Sperm characteristics can be easily analyzed by determining the number, activity, and shape of sperm located in the lattice pattern formed in the center of (a) and (b). More specifically, the inspection device or the external device does not analyze all the sperm distributed throughout the captured image, and sampling analysis may be performed on the sperm in the area partitioned by the partition pattern. Through this, the present invention can be quickly analyzed, it is possible to reduce the pattern processing load of the inspection apparatus, it is possible to perform a more detailed analysis.
  • the partition pattern 10 and 11 illustrate the partition pattern, but the partition pattern may be formed in various shapes such as an ellipse and a circle, and may be arbitrarily designated as well as the center of the screen.
  • the analysis can be performed by applying the partition pattern to a high density to check the image, and the present invention is not limited to the present invention.
  • the inspection apparatus photographs the semen applied to the sample unit 120 to secure a test image.
  • the inspection apparatus calculates the number of sperm identified in a certain area in the test image, the moving distance of the specific sperm, the average of the moving distance, whether to rotate, the rotational speed, and the rotation radius.
  • the inspection apparatus may photograph and use a plurality of test images, or confirm by photographing in a video form.
  • the sperm state can be confirmed by randomly selecting a specific sperm in the image and determining the sperm characteristics of the selected sperm.
  • the inspection apparatus selects some sperm from the test image and processes the image of the selected sperm into a clear pattern or a black and white image and compares whether the sperm is malformed by comparing with a pre-stored image or a form meeting a predetermined condition. It is also possible to discriminate. For example, the number of tails (tails) per hull (round part), the bending of the tail, and the shape of the hull can be determined to determine whether the sperm in the test image has a normal shape.
  • a partition pattern is applied as shown in FIG. 11, and the sperm characteristics of the sperm located in a region defined by the partition pattern among the sperm in the test image are targeted. Can be analyzed.
  • vaginal discharge as in (c) it can be determined whether there is a disease such as bacterial vaginosis, vaginitis, and whether there is a medical examination.
  • a disease such as bacterial vaginosis, vaginitis, and whether there is a medical examination.
  • vaginal discharge is observed using a test apparatus, only vaginal mucosal cells are observed in normal cases, but when a disease caused by bacterial infection occurs as shown in (c) of FIG. The substances can be identified.
  • the secretion of antibacterial substances in the vagina increased and the acidity in the vagina increased and the anaerobic bacteria overproliferated.
  • FIG. 12 is an exemplary view showing a configuration of a sample unit according to a third embodiment of the present invention.
  • the sample part 320 according to the third exemplary embodiment of the present invention includes a base 323 and a conductive pattern 337 formed on the base 323.
  • a form in which the above-described absorber assembly 30 is omitted is disclosed. However, this is for convenience of description and may be configured to include the absorber assembly 30.
  • the configuration of the assembly 30 is as described above.
  • the same or similar technical features as those described above will not be described in detail, and technical features will be described based on differences.
  • the sample part 320 is coated with the body fluid to be tested, and serves as a stage for the camera of the test apparatus to photograph the body fluid.
  • the sample unit 320 serves as a switch for operating the sample unit 20 or by stopping the operation of the sample unit 320 by detachment to the test apparatus.
  • the conductive part 337: 337a and 337b may be formed in the sample part 320.
  • the sample part 320 may include a base 323 on which the conductive pattern 337 is formed and a sheet 321 in which body fluid is accommodated.
  • the base 323 is formed in the form of a thin plate, and is formed of a transparent material for transmitting light and obtaining a clear image, and the sheet 321 is formed.
  • the conductive pattern 337 may be formed on the base 323.
  • the conductive pattern 337 serves as an electrically connected conductor and is electrically connected to an opsovo circuit configured in the test apparatus when the test apparatus sample unit 320 is inserted.
  • the sample unit 320 may operate the test apparatus by insertion, or allow the operating test apparatus to recognize the insertion of the sample unit 320.
  • the specimen unit 320 is removed, it is possible for the test apparatus to recognize this and end the operation.
  • the conductive pattern 337 is to be in electrical contact with the opsovo circuit to complete the circuit of the sensing circuit unit configured in the opsovo circuit. That is, the conductive pattern 337 connects the disconnected portion of the sensing circuit, and energizes through the conductive pattern 337 to recognize the insertion of the sample part 320 by recognizing this by the opsovo circuit, and performs an operation according thereto, or by energizing
  • the test device can be turned on and driven.
  • the conductive patterns 337: 337a and 337b formed on the base 323 may be formed in one or more, and may be formed in pairs as shown.
  • each conductive pattern 337 may be connected to different contacts of the opsovo circuit, but this does not limit the present invention.
  • a pair of conductive patterns connected to the circuit and the cathode circuit are shown as an example.
  • the conductive patterns 337 may be formed with electrode terminals 338: 338a to 338d such that electrical contact with the contacts formed in the sensing circuit of the switching circuit is made stable.
  • the electrode terminal 338 can be formed at each end of the pattern of one conductive pattern 337.
  • the conductive pattern 337 of the present invention can be used as a means for distinguishing the sample unit 320 suitable for the test apparatus, for this purpose, the position of the electrode terminal 338 formed at the end of the conductive pattern 337 May be formed at any predetermined position. That is, the sample portion 320 having a different position of the electrode terminal 338 is inserted by allowing the position of the electrode terminal 338 formed on the conductive pattern 337 and the position of the contact portion formed on the detection circuit to be formed at a predetermined position. If it is possible to prevent the operation. This allows the test apparatus to recognize and operate without undergoing a separate verification process whether or not the sample unit 320 suitable for the test apparatus. Therefore, when the conductive patterns 337 are formed in plural, the shapes of the conductive patterns 337 may be formed to have different shapes and different electrode positions.
  • the conductive pattern 337 may have a back surface of the base 323 as illustrated, that is, a surface other than a surface on which the sheet portion 321 is formed or the opsovo 36 is attached, that is, the side surface of the base 323.
  • a back surface of the base 323 that is, a surface other than a surface on which the sheet portion 321 is formed or the opsovo 36 is attached, that is, the side surface of the base 323.
  • the conductive pattern 337 may be formed using a transparent electrode so as not to impede the imaging, but this is not a limitation of the present invention.
  • the front end 339 of the sample part 320 that is, when the sample part 320 is inserted into the test apparatus, the first inserted part extends in the insertion direction, and the front end 339
  • the conductive pattern 337 may be formed in a limited manner so as not to impede the imaging.
  • the conductive pattern 337 may be formed on the same surface on which the sheet 321 is formed, and in addition to the transparent electrode, the conductive pattern 337 may be formed using a conductive metal such as copper (Cu) or a conductive material such as carbon. It is possible.
  • the opsovo 36 may be coupled to the front end 339 so as to cover the conductive pattern 337, and a short circuit of the conductive pattern 337 may be applied between the opsovo 36 and the conductive pattern 337.
  • An insulating protective layer for preventing can be formed.
  • Figure 13 is an illustration showing another example of a test apparatus according to the present invention.
  • the inspection apparatus 310 serves to determine the user's state by taking the user's body fluid as a sample, the power is turned on or turned on by detecting the insertion of the sample unit 320 The sensing unit 320 to be inserted in to perform the operation.
  • the inspection apparatus 310 has a seating portion 344 supporting the sample portion 320 when the sample portion 320 is inserted, and the seating portion 344 has a conductive pattern formed on the sample portion 320.
  • a contact 345 is formed for making electrical contact with 337.
  • the contact portions 345 are formed in plural to correspond to the positions of the electrode terminals 338 formed on the conductive pattern 337, and each contact portion 345 is connected to a detection circuit (not shown).
  • the detection circuit serves to electrically connect the switching circuit and the contact unit 345, and the switching circuit 95 may be formed separately from the control unit 80 or may be provided as one functional unit of the control unit 80.
  • the switching circuit 95 may be formed at the output terminal of the power supply unit 90 to control the output of the power supply unit 90 so that attachment or detachment of the sample unit 320 and the corresponding operation may be performed. It is not intended to limit the invention.

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Abstract

La présente invention concerne : une unité d'échantillon comportant un élément pour réguler la quantité d'un échantillon de façon à collecter un échantillon optimal pour un essai ; et un dispositif d'essai comprenant l'unité d'échantillon. L'unité d'échantillon selon la présente invention, sur laquelle un fluide corporel est appliqué, et qui est fixée à un dispositif d'essai et détachée de celui-ci pour tester le fluide corporel, comprend : une base comportant une première surface, dont une zone prédéterminée est formée de façon à être enfoncée depuis la première surface et crée ainsi un siège qui contient le fluide corporel ; et un absorbeur qui est formé en une forme annulaire comportant un trou et est couplé à une première surface du bord du siège de façon à ce que le siège soit exposé à travers le trou.
PCT/KR2017/013317 2016-11-22 2017-11-22 Unité d'échantillon pour dispositif d'essai de fluide corporel, et dispositif d'essai de fluide corporel comprenant celle-ci WO2018097585A1 (fr)

Applications Claiming Priority (2)

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KR1020160155782A KR101920273B1 (ko) 2016-11-22 2016-11-22 체액 검사장치용 시료부 및 이를 구비하는 체액 검사장치
KR10-2016-0155782 2016-11-22

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Cited By (1)

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WO2022214021A1 (fr) * 2021-04-08 2022-10-13 雅培诊断产品(上海)有限公司 Boîtier de stylo pour test de grossesse précoce et stylo pour test de grossesse précoce

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KR102008843B1 (ko) * 2019-01-29 2019-08-07 주식회사 스타고 타액을 이용한 스마트폰 기반의 가임기 검사 시스템
KR102333043B1 (ko) * 2019-09-02 2021-12-01 (주)인트인 체액 테스트기
KR102288223B1 (ko) * 2019-09-06 2021-08-10 (주)인트인 체액 검사용 챔버 및 이를 이용하는 체액 검사장치

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JPH06167496A (ja) * 1992-08-31 1994-06-14 Eastman Kodak Co 分離型吸収層を有する乾式イムノアッセイ要素
JP5258579B2 (ja) * 2006-01-25 2013-08-07 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト 電気化学バイオセンサ分析システム
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KR101533107B1 (ko) * 2014-11-14 2015-07-01 (주)종로의료기 스마트폰을 이용한 배란 측정 방법

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WO2022214021A1 (fr) * 2021-04-08 2022-10-13 雅培诊断产品(上海)有限公司 Boîtier de stylo pour test de grossesse précoce et stylo pour test de grossesse précoce

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